locus-tag class description D5F51_00005 ENOG4105QTB Flavodoxin D5F51_00010 ENOG4108VVK transcriptional Regulator, AsnC D5F51_00015 ENOG4105CU9 asparagine synthetase A D5F51_00030 ENOG4105EV2 VWA domain protein interacting with AAA ATPase D5F51_00035 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) D5F51_00045 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) D5F51_00050 ENOG4105C2J ABC transporter D5F51_00055 ENOG4105CNN ABC, transporter D5F51_00060 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D5F51_00065 ENOG4108RVA ribokinase D5F51_00070 ENOG4105ETE Transcriptional regulator (LacI family D5F51_00075 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_00080 ENOG4107EJG GntR family transcriptional regulator D5F51_00110 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b D5F51_00120 ENOG4105PC1 Conserved Protein D5F51_00125 ENOG4105E27 serine threonine protein kinase D5F51_00130 ENOG4108Z33 Thiol disulfide Interchange Protein D5F51_00135 ENOG4105C2M dna polymerase I D5F51_00140 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D5F51_00145 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) D5F51_00155 ENOG4105D4P Coproporphyrinogen iii oxidase D5F51_00160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D5F51_00165 ENOG4105CUX Signal transduction histidine kinase D5F51_00170 ENOG4105C5F glutamine synthetase D5F51_00180 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 D5F51_00185 ENOG4107S2Z UPF0761 membrane protein D5F51_00190 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D5F51_00195 ENOG4105SUU thioesterase domain D5F51_00200 ENOG4105HVQ Regulatory factor of maltose metabolism D5F51_00215 ENOG4105JV1 AsmA family D5F51_00220 ENOG4105C2W permease D5F51_00230 ENOG4105D6U Sodium Glutamate Symporter D5F51_00235 ENOG4105CB5 ATP-dependent DNA helicase recG D5F51_00240 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase D5F51_00245 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D5F51_00250 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D5F51_00260 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) D5F51_00265 ENOG4105EN6 Membrane D5F51_00275 ENOG4105D9N nucleoside D5F51_00280 ENOG4105E39 Enoyl-CoA hydratase D5F51_00285 ENOG4105BZU Histidine kinase D5F51_00290 ENOG4105DSJ YicC domain protein D5F51_00300 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D5F51_00305 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D5F51_00310 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D5F51_00315 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D5F51_00330 ENOG4105KDC 50s ribosomal protein l28 D5F51_00335 ENOG4105W0E 50S ribosomal protein L33 D5F51_00340 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D5F51_00345 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D5F51_00355 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D5F51_00360 ENOG4105D16 lipopolysaccharide heptosyltransferase i D5F51_00365 ENOG4105XA0 heptosyltransferase ii D5F51_00370 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D5F51_00375 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D5F51_00385 ENOG4105PXI polysaccharide deacetylase D5F51_00390 ENOG41063SB peptidase D5F51_00395 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D5F51_00400 ENOG4107YZP Rhodanese domain protein D5F51_00405 ENOG4105VW4 glutaredoxin 3 D5F51_00410 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D5F51_00415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D5F51_00420 ENOG4105D7W serine acetyltransferase D5F51_00425 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D5F51_00430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D5F51_00435 ENOG4105E0F Histidine kinase D5F51_00440 ENOG4105E3W Two component transcriptional regulator (Winged helix family D5F51_00445 ENOG4105FMW periplasmic D5F51_00450 ENOG41076HS cation diffusion facilitator family transporter D5F51_00465 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D5F51_00475 ENOG4105CP7 Triose-phosphate isomerase D5F51_00480 ENOG4105EBK exported protein D5F51_00485 ENOG4108VTS Membrane D5F51_00490 ENOG4105DP0 ferredoxin-NADP reductase D5F51_00495 ENOG4105E5M Multidrug resistance protein D D5F51_00500 ENOG4105CBT Fructose-1,6-bisphosphatase D5F51_00505 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D5F51_00510 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D5F51_00525 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) D5F51_00530 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D5F51_00535 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D5F51_00540 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D5F51_00550 ENOG41063M6 Cell Division Protein D5F51_00555 ENOG4105ETE Transcriptional regulator (LacI family D5F51_00565 ENOG4105C25 Primosomal protein n' D5F51_00575 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) D5F51_00580 ENOG4105C28 cystathionine D5F51_00585 ENOG4105CFH Aspartokinase D5F51_00590 ENOG4105SYT Methylenetetrahydrofolate reductase D5F51_00600 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) D5F51_00610 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D5F51_00620 ENOG4105CH7 arginosuccinase D5F51_00665 ENOG4107QN2 dihydrolipoyl dehydrogenase D5F51_00670 ENOG4105EHV domain protein D5F51_00675 ENOG4105C5Q Transcriptional regulator D5F51_00680 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) D5F51_00685 ENOG4105EJ2 Transcriptional regulator D5F51_00690 ENOG4108Y73 Membrane D5F51_00695 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) D5F51_00705 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D5F51_00750 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator D5F51_00755 ENOG4105C2J ABC transporter D5F51_00760 ENOG4107R9N ABC transporter D5F51_00765 ENOG41062B0 ABC transporter, permease D5F51_00770 ENOG4105CVI Transcriptional regulator D5F51_00775 ENOG4108WFC UPF0438 protein yifE D5F51_00780 ENOG4105C0P Mg chelatase subunit ChlI D5F51_00795 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit D5F51_00800 ENOG4105CM2 brancheD-chain amino acid aminotransferase D5F51_00805 ENOG4105C01 Dihydroxy-acid dehydratase D5F51_00810 ENOG4105C7B Threonine dehydratase D5F51_00815 ENOG4105EMY transcriptional regulator D5F51_00820 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D5F51_00840 ENOG4108VEV chaperone D5F51_00855 ENOG4105GQR Chaperone D5F51_00865 ENOG4105KQ5 peptidylprolyl cis-trans isomerase D5F51_00870 ENOG4105C4R Atp-dependent dna helicase D5F51_00880 ENOG4105C9X ppx gppa phosphatase D5F51_00890 ENOG4105K63 Thioredoxin D5F51_00900 ENOG4105ESV Glycosyl transferase, family 4 D5F51_00905 ENOG4105SFE lipopolysaccharide biosynthesis protein D5F51_00910 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D5F51_00915 ENOG4108IJ1 Dehydrogenase D5F51_00920 ENOG4105C1B dTDP-glucose 4-6-dehydratase D5F51_00925 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D5F51_00930 ENOG4108WJ1 acetyltransferase D5F51_00935 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D5F51_00940 ENOG4105EGZ biosynthesis protein D5F51_00945 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) D5F51_00965 ENOG4105C85 amino acid D5F51_00990 ENOG410601J HemY protein D5F51_00995 ENOG4105ECF c-methyltransferase D5F51_01000 ENOG41076E6 Uroporphyrinogen-III Synthase D5F51_01005 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D5F51_01020 ENOG4105XQ6 frataxin-like protein D5F51_01025 ENOG4105S7Z (LipO)protein D5F51_01030 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D5F51_01035 ENOG4105CT0 Protein of unknown function, DUF484 D5F51_01040 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D5F51_01045 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant D5F51_01050 ENOG4105C4R Atp-dependent dna helicase D5F51_01065 ENOG4105EQN UPF0261 protein D5F51_01080 ENOG4107QUT magnesium and cobalt transport protein CorA D5F51_01085 ENOG4105FR1 rard protein D5F51_01090 ENOG4108VUY thioesterase Superfamily protein D5F51_01095 ENOG4105HDD phospholipase D5F51_01100 ENOG4105C9U ATP-dependent DNA helicase RecQ D5F51_01105 ENOG4105CCF Lysine exporter protein (Lyse ygga) D5F51_01115 ENOG4108EUD Lysophospholipase D5F51_01120 ENOG4105DQF Hydrolase D5F51_01125 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase D5F51_01130 ENOG4105CXY transporter D5F51_01135 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A D5F51_01145 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D5F51_01150 ENOG4108W1V Lipoprotein D5F51_01155 ENOG4105EX9 Membrane D5F51_01160 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D5F51_01170 ENOG4107FS9 Membrane D5F51_01185 ENOG4105MG3 Membrane D5F51_01190 ENOG4106H78 methyltransferase D5F51_01195 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D5F51_01200 ENOG4105CAK Cell division ATP-binding protein ftsE D5F51_01205 ENOG4105CRP Part of the ABC transporter FtsEX involved in D5F51_01215 ENOG4105U59 -acetyltransferase D5F51_01220 ENOG4105CP9 extracellular ligand-binding receptor D5F51_01225 ENOG4105C32 Amino acid ABC transporter (Permease) D5F51_01230 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D5F51_01235 ENOG4105C0Z ABC transporter D5F51_01240 ENOG4108IV0 ABC, transporter D5F51_01290 ENOG4105BZ7 extracellular solute-binding protein family 1 D5F51_01295 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component D5F51_01300 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component D5F51_01305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D5F51_01310 ENOG4107T6V glycerophosphoryl diester phosphodiesterase D5F51_01315 ENOG4105RK9 auxin efflux carrier D5F51_01320 ENOG4105EMK carboxylate amino acid amine transporter D5F51_01325 ENOG4105DZ2 Transcriptional regulator D5F51_01330 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D5F51_01335 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D5F51_01340 ENOG4108I5U Uridine phosphorylase D5F51_01355 ENOG4108KF1 Membrane D5F51_01360 ENOG4105CGY Dna recombination protein D5F51_01365 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D5F51_01370 ENOG4105JC1 sterol-binding domain protein D5F51_01375 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D5F51_01380 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D5F51_01385 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D5F51_01390 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D5F51_01400 ENOG4105D52 delta-aminolevulinic acid dehydratase D5F51_01405 ENOG4105MDZ Transcriptional activator rfaH D5F51_01410 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D5F51_01415 ENOG4107QK7 reductase D5F51_01420 ENOG4105CHU acetyl-coa acetyltransferase D5F51_01425 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D5F51_01435 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D5F51_01440 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D5F51_01445 ENOG4108RR8 protoporphyrinogen oxidase D5F51_01480 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D5F51_01485 ENOG4105CS9 pantothenic acid kinase D5F51_01520 ENOG4105PM1 preprotein translocase subunit SecE D5F51_01525 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D5F51_01530 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D5F51_01545 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D5F51_01550 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D5F51_01555 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D5F51_01560 ENOG4105D41 biosynthesis protein thiH D5F51_01565 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D5F51_01570 ENOG4105WHD thiamine biosynthesis protein ThiS D5F51_01575 ENOG4105D06 uba thif-type nad fad binding protein D5F51_01585 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D5F51_01590 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor D5F51_01595 ENOG4105E09 nadh pyrophosphatase D5F51_01600 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D5F51_01605 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) D5F51_01610 ENOG4105R2J Conserved Protein D5F51_01620 ENOG4108T8B Protein of unknown function (DUF1481) D5F51_01625 ENOG4105C12 Phosphoribosylglycinamide synthetase D5F51_01630 ENOG4105DC1 bifunctional purine biosynthesis protein purh D5F51_01670 ENOG4107QN1 sodium solute D5F51_01675 ENOG41062QD Membrane D5F51_01680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D5F51_01685 ENOG4105CK2 sodium dicarboxylate symporter D5F51_01690 ENOG4105WH1 Two component transcriptional regulator luxr family D5F51_01695 ENOG4105BZU Histidine kinase D5F51_01725 ENOG4105ZQI secreted protein D5F51_01735 ENOG4108SZ7 secretion system effector D5F51_01740 ENOG4106FZW pathogenicity island effector protein D5F51_01795 ENOG4105UQF type iii secretion D5F51_01800 ENOG4106H1D secretion system apparatus protein D5F51_01810 ENOG4108JIR Flagellum-specific ATP synthase D5F51_01825 ENOG41063Q7 Type III secretion system protein D5F51_01830 ENOG4108HHI Type III secretion system protein D5F51_01835 ENOG41083GP type iii secretion D5F51_01840 ENOG4108TN6 type iii secretion D5F51_01845 ENOG4108IUF type iii secretion D5F51_01850 ENOG41066VF YeeE YedE family protein D5F51_01855 ENOG4105KSU Redox protein D5F51_01860 ENOG4105EGS Mechanosensitive ion channel D5F51_01865 ENOG4105E0K tonB-dependent siderophore receptor D5F51_01885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D5F51_01890 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D5F51_01895 ENOG4105EHG Permease protein D5F51_01900 ENOG4107R4I Periplasmic binding protein D5F51_01905 ENOG4106QJH hemin transport protein D5F51_01910 ENOG4107ENK receptor D5F51_01915 ENOG4107F3C Hemin uptake protein D5F51_01925 ENOG41090JE Utilization Protein D5F51_01930 ENOG4105D4P Coproporphyrinogen iii oxidase D5F51_01955 ENOG4108SIC Transcriptional regulator D5F51_01960 ENOG4105CNV Aldolase D5F51_01965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D5F51_01970 ENOG4105BZW Glycerate kinase D5F51_01975 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR D5F51_01980 ENOG4105BZ8 glutamate synthase D5F51_01985 ENOG4108RC0 Electron transport protein D5F51_01990 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D5F51_01995 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D5F51_02005 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D5F51_02020 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D5F51_02025 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D5F51_02035 ENOG4108ZVF (LipO)protein D5F51_02040 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D5F51_02045 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D5F51_02050 ENOG4105KPY Small multidrug resistance protein D5F51_02060 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D5F51_02065 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D5F51_02080 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) D5F51_02085 ENOG4105EGS Mechanosensitive ion channel D5F51_02090 ENOG4105DJ4 phosphatidylserine decarboxylase D5F51_02095 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D5F51_02100 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) D5F51_02125 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D5F51_02130 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D5F51_02135 ENOG4105K8N protein family UPF0079, ATPase D5F51_02140 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D5F51_02145 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D5F51_02150 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D5F51_02155 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D5F51_02160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D5F51_02165 ENOG4107QJR hflk protein D5F51_02170 ENOG4105EPW hflc protein D5F51_02185 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D5F51_02190 ENOG4105KPV Transcriptional regulator D5F51_02195 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D5F51_02200 ENOG4105C2N RNA methyltransferase TrmH family group 3 D5F51_02205 ENOG4105CSU acyl-Coa dehydrogenase D5F51_02210 ENOG4105WSB biofilm stress and motility protein A D5F51_02215 ENOG4108MXZ Esterase D5F51_02230 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D5F51_02235 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) D5F51_02240 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D5F51_02245 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D5F51_02255 ENOG4105FHY Opacity-associated protein A D5F51_02260 ENOG4108V1T peptidylprolyl cis-trans isomerase D5F51_02270 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic D5F51_02275 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase D5F51_02280 ENOG4108UUE Transcriptional regulator D5F51_02285 ENOG41061GZ Protein of unknown function (DUF1107) D5F51_02290 ENOG4105C37 (CBS) domain D5F51_02295 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D5F51_02300 ENOG4105CFU surface antigen D5F51_02310 ENOG4108ZHD aig2 family D5F51_02315 ENOG4105F0N pyrophosphate phospho-hydrolase D5F51_02320 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_02325 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D5F51_02330 ENOG4105DFU Cell wall formation (By similarity) D5F51_02340 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) D5F51_02345 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D5F51_02350 ENOG4105HVQ Regulatory factor of maltose metabolism D5F51_02360 ENOG4105EAH synthase D5F51_02375 ENOG4105QYV Membrane D5F51_02380 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D5F51_02395 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D5F51_02400 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D5F51_02405 ENOG4105HBR Rna-binding protein D5F51_02410 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D5F51_02415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D5F51_02420 ENOG4105EEI dihydropteroate synthase D5F51_02450 ENOG4105CHV Transcription elongation factor NusA D5F51_02460 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D5F51_02465 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D5F51_02475 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D5F51_02490 ENOG4105C1J atp-dependent rna helicase D5F51_02495 ENOG4105DEN Luciferase family D5F51_02515 ENOG4106RZ4 Peptidase U32 D5F51_02520 ENOG4105CFP Peptidase U32 D5F51_02525 ENOG4105XPQ lipid carrier protein D5F51_02530 ENOG4108YYD acetyltransferase D5F51_02540 ENOG4105D5Q Arginine ornithine antiporter D5F51_02545 ENOG4105CXN decarboxylase D5F51_02560 ENOG4105EY3 heparinase II III family protein D5F51_02570 ENOG4105E0S extracellular solute-binding protein family 1 D5F51_02575 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component D5F51_02580 ENOG4105DRS transport system, permease D5F51_02595 ENOG4108ZPB UPF0306 protein D5F51_02600 ENOG4105K4T epimerase D5F51_02605 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein D5F51_02610 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) D5F51_02615 ENOG4105FD8 phosphonate metabolism protein PhnM D5F51_02620 ENOG4105HRV phosphonate c-p lyase system protein phnl D5F51_02625 ENOG4105ENV phosphonate C-P lyase system protein PhnK D5F51_02630 ENOG4105FT8 Phosphonate metabolism D5F51_02635 ENOG4105EKV Phosphonate metabolism protein D5F51_02645 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG D5F51_02650 ENOG4107RJJ Transcriptional regulator D5F51_02665 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) D5F51_02670 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase D5F51_02675 ENOG410642W LysR family Transcriptional regulator D5F51_02680 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D5F51_02685 ENOG4108JQ7 (ABC) transporter D5F51_02690 ENOG4105C3U ABC transporter D5F51_02695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5F51_02700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D5F51_02705 ENOG4105DEF Extracellular solute-binding protein, family 5 D5F51_02710 ENOG4105XEP YhcH YjgK YiaL family protein D5F51_02720 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) D5F51_02730 ENOG4108MJ3 acetyltransferase D5F51_02740 ENOG4105MYG DNA polymerase iii, chi subunit D5F51_02745 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D5F51_02750 ENOG4108M8S permease YjgP YjgQ family protein D5F51_02755 ENOG4108K5H permease YjgP YjgQ family protein D5F51_02805 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) D5F51_02810 ENOG4105NI8 Cytosine-specific methyltransferase D5F51_02865 ENOG4108MXD gtp-binding protein D5F51_02875 ENOG4108KZE transcriptional regulator D5F51_02890 ENOG4106J9S Prophage D5F51_02895 ENOG4106ZN7 UPF0401 protein YkfF D5F51_02900 ENOG4105MFG Antirestriction protein D5F51_02905 ENOG4108XS9 dna repair protein D5F51_02915 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures D5F51_02930 ENOG4105VEV -acetyltransferase D5F51_02945 ENOG4105RI1 glycoprotein receptor D5F51_02955 ENOG4107SEY Conserved Protein D5F51_02960 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound D5F51_02965 ENOG41061GT Aldolase D5F51_02970 ENOG4105D4B ABC, transporter D5F51_02975 ENOG4105F5R ABC transporter D5F51_02980 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane D5F51_02985 ENOG4105C2J ABC transporter D5F51_02995 ENOG4105DKT Transcriptional regulator D5F51_03000 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) D5F51_03005 ENOG4105DKP glycosyl transferase, family 9 D5F51_03015 ENOG4105D5Q Arginine ornithine antiporter D5F51_03020 ENOG4105CEU Arginine dihydrolase D5F51_03030 ENOG410624X efflux transporter, rnd family, mfp subunit D5F51_03035 ENOG4105BZS acriflavin resistance protein D5F51_03045 ENOG4105CMT Dihydroxyacetone kinase D5F51_03050 ENOG4108UTZ Dihydroxyacetone kinase D5F51_03055 ENOG4105VDH Dihydroxyacetone kinase D5F51_03100 ENOG4105WBN Transcriptional regulator (LacI family D5F51_03115 ENOG4106TD9 Diguanylate cyclase D5F51_03120 ENOG4105YBH Protein of unknown function (DUF1435) D5F51_03145 ENOG4105CPC Aldo Keto reductase D5F51_03150 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D5F51_03155 ENOG4108WPU DNA polymerase III subunit psi D5F51_03160 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D5F51_03165 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D5F51_03170 ENOG4105K3G Periplasmic Protein D5F51_03180 ENOG4108NRW Phospholipase, patatin family D5F51_03185 ENOG4105EYA deoxyribonuclease D5F51_03190 ENOG4105D9N nucleoside D5F51_03200 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D5F51_03205 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D5F51_03210 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D5F51_03220 ENOG41062Z9 Membrane D5F51_03225 ENOG4105EAC phosphoserine phosphatase D5F51_03230 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D5F51_03235 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase D5F51_03240 ENOG4105CIS alcohol dehydrogenase D5F51_03250 ENOG4105C5H ABC transporter D5F51_03255 ENOG4107R08 Integrase D5F51_03300 ENOG4108R7K Metal Dependent Phosphohydrolase D5F51_03305 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) D5F51_03310 ENOG4105H40 D5F51_03335 ENOG4108S1U D5F51_03345 ENOG4105CAR Terminase, large subunit D5F51_03365 ENOG4108MXB Protein of unknown function (DUF968) D5F51_03370 ENOG4105HRS Antitermination protein D5F51_03400 ENOG4105NVB glycoside hydrolase, family 19 D5F51_03530 ENOG41090EK ompa motb domain protein D5F51_03535 ENOG4108KHX Diguanylate cyclase D5F51_03550 ENOG4107SC1 transglycosylase D5F51_03555 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) D5F51_03560 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D5F51_03565 ENOG4105CVJ phosphoglycerate mutase D5F51_03570 ENOG4105UEI Transcriptional Regulator AraC Family D5F51_03575 ENOG4108RH0 Crea protein D5F51_03580 ENOG41065U4 response regulator D5F51_03595 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D5F51_03605 ENOG4105D1Q UPF0246 protein D5F51_03615 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D5F51_03620 ENOG4108RIR Molybdenum cofactor biosynthesis protein D5F51_03635 ENOG4106HK8 GPR1 FUN34 yaaH family protein D5F51_03645 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D5F51_03650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D5F51_03655 ENOG41063Z6 transcriptional regulator, lysR family D5F51_03675 ENOG4105DTN riboflavin biosynthesis protein ribF D5F51_03680 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D5F51_03685 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D5F51_03690 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase D5F51_03695 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D5F51_03700 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D5F51_03705 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D5F51_03710 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D5F51_03715 ENOG4105N14 lysine exporter protein LysE YggA D5F51_03720 ENOG4105DWK Membrane D5F51_03725 ENOG4107XM3 UPF0442 protein D5F51_03730 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D5F51_03735 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D5F51_03740 ENOG4105NWN ApaG protein D5F51_03750 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D5F51_03755 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D5F51_03760 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D5F51_03765 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) D5F51_03775 ENOG4105D3G Pseudouridine synthase D5F51_03780 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) D5F51_03785 ENOG4105CQ2 DNA polymerase D5F51_03790 ENOG4108KF1 Membrane D5F51_03800 ENOG4106SMU thiamine transporter membrane protein D5F51_03805 ENOG4105DP9 ABC transporter D5F51_03810 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) D5F51_03815 ENOG4105F1A Pyruvate formate-lyase D5F51_03820 ENOG4105C6N Formate acetyltransferase D5F51_03825 ENOG4105S8Q sugar efflux transporter D5F51_03830 ENOG4105CIC tryptophan-specific transport protein D5F51_03835 ENOG4105C0F tryptophanase EC 4.1.99.1 D5F51_03850 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D5F51_03855 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D5F51_03860 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D5F51_03875 ENOG41064T2 transcriptional regulator, lysR family D5F51_03880 ENOG4108IQE Amp-dependent synthetase and ligase D5F51_03885 ENOG4105C7K acetolactate synthase D5F51_03890 ENOG4108ZP8 Acetolactate synthase small subunit D5F51_03895 ENOG4107B7Y DNA-binding transcriptional regulator FruR D5F51_03910 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D5F51_03915 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D5F51_03920 ENOG4105CJN penicillin-binding protein D5F51_03925 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D5F51_03930 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) D5F51_03935 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D5F51_03945 ENOG4105CNI cell division protein FtsW D5F51_03950 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D5F51_03955 ENOG4105DFU Cell wall formation (By similarity) D5F51_03965 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D5F51_03970 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D5F51_03975 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D5F51_03990 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) D5F51_03995 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D5F51_04000 ENOG4105M6F mutator MutT protein D5F51_04005 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) D5F51_04015 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D5F51_04025 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D5F51_04045 ENOG4107QHF type ii secretion system protein e D5F51_04050 ENOG4108ZUW Major pilin subunit D5F51_04055 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D5F51_04060 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D5F51_04065 ENOG4106A72 regulatory protein AmpE D5F51_04135 ENOG4105TKZ Tail Sheath D5F51_04160 ENOG4105EFV Major head subunit D5F51_04190 ENOG4105QIB mu-like prophage Flumu protein gp29 D5F51_04230 ENOG4105NVB glycoside hydrolase, family 19 D5F51_04245 ENOG4105ZIA Phage protein gp16 D5F51_04325 ENOG4105HVQ Regulatory factor of maltose metabolism D5F51_04345 ENOG4105C85 amino acid D5F51_04350 ENOG41073TP transcriptional regulator D5F51_04360 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D5F51_04365 ENOG4107QSN dihydrolipoamide acetyltransferase D5F51_04370 ENOG4107QN2 dihydrolipoyl dehydrogenase D5F51_04385 ENOG4107RNH Outer membrane receptor FepA D5F51_04390 ENOG4107QIJ Aconitate hydratase 2 D5F51_04395 ENOG4108ZIG UPF0231 protein D5F51_04400 ENOG4105RPH Inner membrane protein YddG D5F51_04410 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) D5F51_04415 ENOG4108ZRK uncharacterized protein yacC D5F51_04420 ENOG4105E3B Multicopper oxidase D5F51_04425 ENOG4108UGV hypoxanthine phosphoribosyltransferase D5F51_04430 ENOG41077A9 carbonic anhydrase D5F51_04435 ENOG4105DA5 (ABC) transporter D5F51_04440 ENOG4105E3A (ABC) transporter D5F51_04445 ENOG4107BJW polysaccharide deacetylase D5F51_04450 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D5F51_04455 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D5F51_04460 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D5F51_04465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D5F51_04470 ENOG4105DJ0 Poly(A) Polymerase D5F51_04475 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) D5F51_04480 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D5F51_04490 ENOG4105PW4 Sugar fermentation stimulation protein homolog D5F51_04495 ENOG4107XID 2'-5' rna ligase D5F51_04500 ENOG4105CQ7 ATP-dependent helicase D5F51_04505 ENOG4105BZ4 penicillin-binding protein D5F51_04510 ENOG4105E0A ABC, transporter D5F51_04515 ENOG4105J76 Periplasmic binding protein D5F51_04520 ENOG4105S6R Iron-hydroxamate transporter permease subunit D5F51_04525 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D5F51_04535 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D5F51_04545 ENOG4105EN6 Membrane D5F51_04555 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D5F51_04560 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D5F51_04565 ENOG4105C0H protease D5F51_04570 ENOG4105BZU Histidine kinase D5F51_04575 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D5F51_04580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D5F51_04585 ENOG4105DXN mazG family D5F51_04590 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D5F51_04595 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D5F51_04605 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D5F51_04610 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D5F51_04615 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D5F51_04620 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D5F51_04625 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D5F51_04630 ENOG4108MXK alkaline phosphatase isozyme conversion D5F51_04635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D5F51_04640 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D5F51_04645 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) D5F51_04650 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) D5F51_04655 ENOG4105N0Z inner membrane protein ygbE D5F51_04665 ENOG4105DRP amino acid AbC transporter D5F51_04670 ENOG4106PMH Extracellular solute-binding protein family 3 D5F51_04675 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D5F51_04685 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D5F51_04690 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) D5F51_04695 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D5F51_04700 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D5F51_04705 ENOG4108K5P (LipO)protein D5F51_04710 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D5F51_04715 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D5F51_04730 ENOG4107B2H carbonic anhydrase D5F51_04735 ENOG4105D6U Sodium Glutamate Symporter D5F51_04760 ENOG4105CKT filamentous hemagglutinin D5F51_04795 ENOG4105D5K Hemolysin activator protein D5F51_04805 ENOG4105M2Z protein tyrosine serine phosphatase D5F51_04835 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) D5F51_04840 ENOG41060IM Heme exporter protein D5F51_04845 ENOG4105X3C heme exporter protein D5F51_04850 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) D5F51_04855 ENOG4105DA4 cytochrome c-type biogenesis protein D5F51_04860 ENOG4107QX9 Thiol disulfide interChange protein D5F51_04865 ENOG4108M1T Cytochrome c-type biogenesis protein D5F51_04870 ENOG4105KWW Biogenesis protein D5F51_04875 ENOG410903C (LipO)protein D5F51_04880 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D5F51_04885 ENOG4105KZW UPF0381 protein D5F51_04890 ENOG4105CHU acetyl-coa acetyltransferase D5F51_04895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D5F51_04900 ENOG4108BY2 phosphohistidine phosphatase D5F51_04905 ENOG4108DG9 Smr protein MutS2 D5F51_04910 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) D5F51_04915 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D5F51_04920 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) D5F51_04925 ENOG4105EJ9 Membrane D5F51_04930 ENOG4108BPE -transporting atpase D5F51_04935 ENOG4105MH2 YfcL protein D5F51_04940 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) D5F51_04945 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D5F51_04965 ENOG4105VCP PTS System D5F51_04970 ENOG4105CS2 ec 3.2.1.21 D5F51_04975 ENOG4105CK1 PTS System D5F51_04990 ENOG4105D6F Phosphatase D5F51_04995 ENOG4105F4P )-transporter D5F51_05000 ENOG4106WZ1 flagella biosynthesis regulator D5F51_05010 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D5F51_05020 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D5F51_05025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D5F51_05035 ENOG410631K Membrane D5F51_05045 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) D5F51_05050 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D5F51_05060 ENOG4105DQR SNARE associated Golgi D5F51_05065 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D5F51_05070 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D5F51_05075 ENOG4108S3P Sporulation domain protein D5F51_05080 ENOG4105E96 Colicin v production protein D5F51_05085 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D5F51_05090 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D5F51_05100 ENOG4105E89 ABC transporter D5F51_05105 ENOG4105DSP amino acid AbC transporter D5F51_05110 ENOG4106YG3 ABC transporter D5F51_05115 ENOG4108JEH abc transporter atp-binding protein D5F51_05120 ENOG4105ECP epimerase D5F51_05130 ENOG4108RE9 Phosphodiesterase D5F51_05135 ENOG4105PTV Nudix Hydrolase D5F51_05140 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC D5F51_05150 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia D5F51_05155 ENOG4107P2S Transcriptional regulator D5F51_05160 ENOG4105C6K Malic enzyme D5F51_05170 ENOG4105PQ6 UPF0208 membrane protein D5F51_05175 ENOG4105XWI UPF0304 protein D5F51_05180 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 D5F51_05190 ENOG4107QWE )-transporter D5F51_05200 ENOG4105DK2 UPF0207 protein D5F51_05205 ENOG4105CHM Aminotransferase D5F51_05210 ENOG4107NQ8 LysR family Transcriptional regulator D5F51_05215 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D5F51_05220 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D5F51_05225 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D5F51_05230 ENOG4105GKE subunit e D5F51_05235 ENOG4107QIZ NADH dehydrogenase D5F51_05240 ENOG4108IEH NADH dehydrogenase subunit g D5F51_05245 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) D5F51_05250 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D5F51_05255 ENOG4107UFS subunit j D5F51_05260 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D5F51_05265 ENOG4105D65 subunit l D5F51_05270 ENOG4105C8S subunit m D5F51_05275 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D5F51_05285 ENOG4108UQ5 membrane protein YcdZ D5F51_05300 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D5F51_05305 ENOG4105CHR reductase D5F51_05310 ENOG4105K2J Transcriptional regulator D5F51_05315 ENOG4105C5I Dehydrogenase D5F51_05325 ENOG41090KN UPF0303 protein D5F51_05335 ENOG4105TNS Conserved Protein D5F51_05340 ENOG4105E4F Isochorismate synthase D5F51_05345 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D5F51_05350 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D5F51_05355 ENOG4108IPT Naphthoate synthase D5F51_05360 ENOG4105DNI Converts SHCHC to OSB (By similarity) D5F51_05365 ENOG4105CEY Amp-dependent synthetase and ligase D5F51_05370 ENOG4105CH6 catalase D5F51_05375 ENOG4108UII YfaZ family D5F51_05380 ENOG4105E0U tyrosine-specific transport protein D5F51_05390 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) D5F51_05395 ENOG4105XPH Ferredoxin D5F51_05400 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D5F51_05405 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D5F51_05410 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D5F51_05415 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5F51_05420 ENOG4105BZU Histidine kinase D5F51_05425 ENOG41068CG regulatoR D5F51_05430 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC D5F51_05435 ENOG4106UW1 Major Facilitator superfamily D5F51_05460 ENOG4107R6D beta-lactam binding protein AmpH D5F51_05465 ENOG4105CT4 transporter D5F51_05475 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_05480 ENOG4105Y50 Virulence Protein D5F51_05485 ENOG4105HX0 Transcriptional regulator D5F51_05490 ENOG4105C5Y PTS System D5F51_05495 ENOG4105CS2 ec 3.2.1.21 D5F51_05515 ENOG4105E68 Sulfatase D5F51_05520 ENOG4105PAN UPF0352 protein D5F51_05525 ENOG4106V8H Nucleoid-associated protein D5F51_05535 ENOG4105CFI type iii restriction protein res subunit D5F51_05540 ENOG4105I08 Pseudouridine synthase D5F51_05545 ENOG4105C2C drug resistance transporter, Bcr CflA D5F51_05550 ENOG4105HG6 D5F51_05555 ENOG4108JQ5 ABC transporter D5F51_05560 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component D5F51_05565 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component D5F51_05570 ENOG4105E43 Extracellular solute-binding protein, family 5 D5F51_05575 ENOG4105CXC rtn protein D5F51_05585 ENOG4107TT5 NLP P60 protein D5F51_05590 ENOG41076MN Phosphoesterase, PA-phosphatase related D5F51_05595 ENOG4105CKI cobalamin synthesis protein D5F51_05605 ENOG4107YCY Transcriptional regulator D5F51_05610 ENOG4105DEI Mannitol dehydrogenase D5F51_05620 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D5F51_05625 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D5F51_05635 ENOG4105KRS Proteinase inhibitor D5F51_05645 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein D5F51_05650 ENOG4105DE4 1-phosphofructokinase D5F51_05655 ENOG4105DM4 PTS System D5F51_05660 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D5F51_05665 ENOG4105HMI Membrane D5F51_05675 ENOG4105DUM transcriptional regulator, lysR family D5F51_05680 ENOG4108IQI permease D5F51_05685 ENOG4105EHG Permease protein D5F51_05695 ENOG4105D05 Receptor D5F51_05700 ENOG4108TGY Glutathione S-transferase D5F51_05720 ENOG4105D01 (LipO)protein D5F51_05730 ENOG4108UMI ABC transporter, permease D5F51_05735 ENOG4105C28 cystathionine D5F51_05745 ENOG4105DZ1 carboxypeptidase D5F51_05750 ENOG4105EJQ L-serine dehydratase D5F51_05755 ENOG4105C44 Serine transporter D5F51_05760 ENOG4107FB0 transcriptional regulator DeoR family D5F51_05765 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D5F51_05770 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D5F51_05780 ENOG4105D0C transport protein D5F51_05785 ENOG41090BQ Glutaredoxin D5F51_05790 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress D5F51_05795 ENOG4108RMJ sensory transduction regulator D5F51_05800 ENOG4107RUE extracellular solute-binding protein family 1 D5F51_05805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D5F51_05810 ENOG4105F38 ABC transporter, permease D5F51_05815 ENOG4105D38 putrescine abc transporter D5F51_05820 ENOG4105RBQ inner membrane protein ybjO D5F51_05825 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) D5F51_05830 ENOG4106TNF Periplasmic binding protein D5F51_05840 ENOG4105DMR ABC, transporter D5F51_05845 ENOG4105GBT ABC transporter D5F51_05850 ENOG4106PMH Extracellular solute-binding protein family 3 D5F51_05855 ENOG4105E5Z arginine transporter ATP-binding subunit D5F51_05860 ENOG41064MM (LipO)protein D5F51_05870 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase D5F51_05875 ENOG4105CGD Nad-dependent epimerase dehydratase D5F51_05880 ENOG4105C5W Aldolase D5F51_05885 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) D5F51_05890 ENOG4105C7K acetolactate synthase D5F51_05895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D5F51_05900 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) D5F51_05905 ENOG4105DWU Membrane D5F51_05910 ENOG4105CPB ATP-dependent endonuclease of the OLD family D5F51_05915 ENOG4108MJ5 VirK protein D5F51_05920 ENOG4105DJY efflux transporter, rnd family, mfp subunit D5F51_05930 ENOG4105VEQ Cold shock protein D5F51_05935 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D5F51_05940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5F51_05945 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D5F51_05950 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) D5F51_05955 ENOG4108JJ8 (ABC) transporter D5F51_05960 ENOG4108JJ9 ABC, transporter D5F51_05965 ENOG4105C3M thioredoxin reductase D5F51_05970 ENOG4105EW9 transcriptional regulator AsnC family D5F51_05975 ENOG4105CNU cell division protein FtsK D5F51_05980 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) D5F51_05985 ENOG4105D1H recombination factor protein RarA D5F51_05995 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D5F51_06000 ENOG4108ISG Major Facilitator D5F51_06005 ENOG4105F1A Pyruvate formate-lyase D5F51_06010 ENOG4105C6N Formate acetyltransferase D5F51_06015 ENOG4105TMB Formate nitrite transporter D5F51_06020 ENOG4105DDY UPF0142 protein ycaO D5F51_06025 ENOG4105HDK L-asparaginase D5F51_06030 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D5F51_06035 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D5F51_06040 ENOG4105CAT Cytidine monophosphate kinase D5F51_06045 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D5F51_06050 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D5F51_06055 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 D5F51_06065 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D5F51_06070 ENOG4105E32 cytoplasmic protein D5F51_06075 ENOG4105VEQ Cold shock protein D5F51_06080 ENOG4105VEQ Cold shock protein D5F51_06085 ENOG4105W49 UPF0434 protein D5F51_06090 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D5F51_06095 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups D5F51_06100 ENOG4107S90 membrAne D5F51_06105 ENOG4106371 Methyltransferase D5F51_06110 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) D5F51_06115 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) D5F51_06120 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) D5F51_06125 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D5F51_06130 ENOG4105EAQ (twin-arginine translocation) pathway signal D5F51_06135 ENOG4105C5X domain protein D5F51_06140 ENOG4105BZU Histidine kinase D5F51_06145 ENOG4105CGF Aromatic amino acid aminotransferase D5F51_06155 ENOG4105C5S asparaginyl-tRNA synthetase D5F51_06160 ENOG4107RH7 Nicotinate phosphoribosyltransferase D5F51_06165 ENOG4105DBA pectate lyase D5F51_06170 ENOG4105CD8 aminopeptidase N D5F51_06175 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D5F51_06180 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) D5F51_06185 ENOG4105QVC MOSC domain-containing protein D5F51_06190 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D5F51_06195 ENOG4105C5H ABC transporter D5F51_06200 ENOG4105F1S paraquat-inducible protein a D5F51_06205 ENOG4105DY2 Paraquat-inducible protein b D5F51_06210 ENOG4108Q2G (LipO)protein D5F51_06215 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) D5F51_06220 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D5F51_06230 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) D5F51_06235 ENOG4105DAN ATP-dependent protease D5F51_06240 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) D5F51_06245 ENOG4105UYK outer membrane protein a D5F51_06250 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) D5F51_06255 ENOG4108RZ1 DNA transformation protein D5F51_06260 ENOG4105EM2 membrane D5F51_06265 ENOG410901E Membrane D5F51_06270 ENOG41088T4 Helicase IV D5F51_06275 ENOG4108Z5K methylglyoxal synthase D5F51_06280 ENOG4108Q67 UPF0319 protein D5F51_06285 ENOG4105K4P CoA-binding domain protein D5F51_06290 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) D5F51_06295 ENOG4105DR4 Methyltransferase D5F51_06310 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D5F51_06315 ENOG4108Z0T Part of a sulfur-relay system (By similarity) D5F51_06325 ENOG4105VJY transcriptional regulator D5F51_06330 ENOG4107YC3 synthase D5F51_06340 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) D5F51_06355 ENOG4105DJ9 glucan biosynthesis protein D5F51_06360 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) D5F51_06365 ENOG4105NAC (LipO)protein D5F51_06375 ENOG4105DUX Transporter D5F51_06380 ENOG4105C6X Major Facilitator D5F51_06385 ENOG4108VGI doxx family D5F51_06390 ENOG4105D1S lipid A biosynthesis D5F51_06415 ENOG4105DSF transport protein D5F51_06420 ENOG4106974 biofilm formation D5F51_06435 ENOG4105PVA Biofilm formation regulatory protein BssS D5F51_06445 ENOG4105EKE dihydroorotase D5F51_06450 ENOG41067V3 Antibiotic biosynthesis monooxygenase D5F51_06455 ENOG4107QQB Ribonuclease E D5F51_06455 ENOG4107QQB Ribonuclease E D5F51_06465 ENOG4105EI2 Pseudouridine synthase D5F51_06475 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D5F51_06480 ENOG4105VGS 50s ribosomal protein l32 D5F51_06485 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D5F51_06495 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D5F51_06500 ENOG4105CHR reductase D5F51_06510 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D5F51_06515 ENOG4105YAZ 4-amino-4-deoxychorismate lyase D5F51_06520 ENOG4105HHA aminodeoxychorismate lyase D5F51_06525 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D5F51_06530 ENOG4107QRG dna polymerase iii D5F51_06535 ENOG4105F8V Hydrolase, tatD family D5F51_06540 ENOG4105CI1 PTS System D5F51_06550 ENOG4105F9E Shikimate 5-dehydrogenase D5F51_06555 ENOG4105K59 histidine triad (HIT) protein D5F51_06560 ENOG41090DQ Lipoprotein D5F51_06565 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) D5F51_06570 ENOG4108RUM thiamine kinase D5F51_06575 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) D5F51_06580 ENOG4105D0Y UPF0227 protein D5F51_06585 ENOG4105CEP NADH dehydrogenase D5F51_06590 ENOG4107MBR 17 kDa surface antigen D5F51_06595 ENOG4108JA2 transcriptioN-repair coupling factor D5F51_06600 ENOG4105D60 lipoprotein releasing system transmembrane protein D5F51_06610 ENOG4105D60 lipoprotein releasing system transmembrane protein D5F51_06615 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) D5F51_06620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D5F51_06630 ENOG4105EZE Cupin 4 family protein D5F51_06640 ENOG4105XJC Two component transcriptional regulator (Winged helix family D5F51_06650 ENOG4107QTF adenylosuccinate lyase D5F51_06655 ENOG41075W9 High frequency lysogenization protein HflD homolog D5F51_06660 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D5F51_06670 ENOG4108R99 pseudouridine synthase D5F51_06675 ENOG4108HMX isocitrate dehydrogenase (NADP) D5F51_06695 ENOG4108HKT sucrose-6-phosphate hydrolase D5F51_06700 ENOG4106NDP Transcriptional regulator D5F51_06710 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D5F51_06720 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D5F51_06725 ENOG4105KT5 UmuD protein D5F51_06730 ENOG4108IQK o-acetylhomoserine D5F51_06735 ENOG4105ECR NmrA family D5F51_06740 ENOG4105KVH Transcriptional regulator D5F51_06755 ENOG4105CTX dehydratase D5F51_06760 ENOG4107QZW Altronate oxidoreductase D5F51_06765 ENOG4105CPQ Dehydrogenase D5F51_06770 ENOG410617M Transcriptional regulator D5F51_06775 ENOG4105DIA mandelate racemase muconate lactonizing D5F51_06780 ENOG4105CSP Major Facilitator Superfamily D5F51_06795 ENOG4105VTN Protein of unknown function (DUF1311) D5F51_06800 ENOG4105XXV Acid-resistance protein D5F51_06820 ENOG4105BZ1 (ABC) transporter D5F51_06830 ENOG4105D5Q Arginine ornithine antiporter D5F51_06845 ENOG4105N4N Protein of unknown function (DUF2766) D5F51_06850 ENOG4105TIK D5F51_06860 ENOG41064PC D5F51_06875 ENOG4105C85 amino acid D5F51_06880 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) D5F51_06885 ENOG410610J Protein of unknown function (DUF2627) D5F51_06890 ENOG4105VEQ Cold shock protein D5F51_06895 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D5F51_06900 ENOG4105CJN penicillin-binding protein D5F51_06905 ENOG4105DHI Methyltransferase D5F51_06915 ENOG4105BZU Histidine kinase D5F51_06925 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) D5F51_06930 ENOG4108NK4 UPF0266 membrane protein D5F51_06935 ENOG4105F3R pts system mannose fructose sorbose family iid D5F51_06940 ENOG4105ETZ PTS System D5F51_06945 ENOG4108EQA pts system D5F51_06950 ENOG4105EE5 Membrane protein terC D5F51_06960 ENOG4105EJQ L-serine dehydratase D5F51_06965 ENOG4105P8F nudix hydrolase D5F51_06970 ENOG4105CRQ synthase (Component I) D5F51_06975 ENOG4105X5C UPF0181 protein D5F51_06980 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D5F51_06985 ENOG4105C1J atp-dependent rna helicase D5F51_06990 ENOG4105X2V dna damage-inducible protein D5F51_06995 ENOG4105N5Z UPF0267 protein D5F51_07005 ENOG4105CUG Oligopeptidase b D5F51_07010 ENOG4105UMD exodeoxyribonuclease X D5F51_07020 ENOG4105MPK DNA polymerase III subunit theta D5F51_07025 ENOG41090A1 ferritin D5F51_07030 ENOG4105FXM Copper resistance protein D5F51_07035 ENOG4108PNC copper resistance D5F51_07040 ENOG4105NKT exported protein D5F51_07045 ENOG4108I1J Integrase D5F51_07085 ENOG41087BU transcriptional repressor DicA D5F51_07145 ENOG4105RWQ Protein of unknown function (DUF1364) D5F51_07150 ENOG4105HRS Antitermination protein D5F51_07160 ENOG4106V8H Nucleoid-associated protein D5F51_07190 ENOG4108ES9 ParB domain protein nuclease D5F51_07225 ENOG4107ZQ5 Phage-associated protein, HI1409 family D5F51_07235 ENOG41090AG Bacteriophage protein D5F51_07345 ENOG4105UZW Tail fiber assembly protein D5F51_07350 ENOG4105EXC Acyl-transferase D5F51_07460 ENOG4107ZUJ lipid metabolic process D5F51_07485 ENOG41066YJ Beta-lactamase D5F51_07490 ENOG4105FE9 pseudouridine synthase D5F51_07515 ENOG4108SHQ Glutathione S-transferase D5F51_07540 ENOG4105WT8 Protein of unknown function (DUF1480) D5F51_07580 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_07590 ENOG4105DY2 Paraquat-inducible protein b D5F51_07595 ENOG4105H2K paraquat-inducible protein a D5F51_07600 ENOG4108ZGC gaf domain protein D5F51_07610 ENOG4105CN1 protease D5F51_07615 ENOG4105D0M Protease HtpX homolog D5F51_07620 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_07625 ENOG4105CAZ oligogalacturonide lyase D5F51_07635 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D5F51_07640 ENOG4108ETY sodium dicarboxylate symporter D5F51_07645 ENOG4107K5X Membrane-bound metal-dependent hydrolase D5F51_07650 ENOG4108PU9 oligogalacturonate-specific porin D5F51_07660 ENOG4108IJ9 (ABC) transporter D5F51_07665 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component D5F51_07670 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component D5F51_07675 ENOG41061NF Pectate lyase D5F51_07680 ENOG4105CHR reductase D5F51_07685 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) D5F51_07690 ENOG4105M5J Cupin 2, conserved barrel domain protein D5F51_07695 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 D5F51_07700 ENOG4107PN8 YfeABCD locus regulator D5F51_07705 ENOG4105DEQ transcriptional regulator D5F51_07710 ENOG4105CYC Transferase D5F51_07715 ENOG4108M7F enoyl-CoA hydratase isomerase D5F51_07720 ENOG4105DJT lAO AO transport system ATPase D5F51_07725 ENOG4105D5P Methylmalonyl-coA mutase D5F51_07735 ENOG4105FGM Fructosamine kinase D5F51_07740 ENOG4105CC5 ABC transporter D5F51_07745 ENOG4105CC5 ABC transporter D5F51_07750 ENOG4105DIK (ABC) transporter D5F51_07755 ENOG4105DSE periplasmic solute binding protein D5F51_07760 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D5F51_07765 ENOG41082NP Multiple antibiotic resistance D5F51_07790 ENOG4108UQV Membrane D5F51_07795 ENOG41087WU D5F51_07800 ENOG4105C22 threonyL-tRNA synthetase D5F51_07805 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D5F51_07815 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D5F51_07830 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D5F51_07835 ENOG4105YB8 TM2 domain containing protein D5F51_07845 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) D5F51_07850 ENOG4108V06 Glutathione peroxidase D5F51_07855 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) D5F51_07860 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D5F51_07865 ENOG4105CKK Glycosyl transferase, family 2 D5F51_07875 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D5F51_07880 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D5F51_07885 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) D5F51_07890 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) D5F51_07895 ENOG4108QBX (LipO)protein D5F51_07900 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) D5F51_07910 ENOG4107R4I Periplasmic binding protein D5F51_07915 ENOG4106QJH hemin transport protein D5F51_07920 ENOG4107ENK receptor D5F51_07925 ENOG4107F3C Hemin uptake protein D5F51_07930 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D5F51_07935 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D5F51_07940 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D5F51_07950 ENOG4105IPI Membrane D5F51_07955 ENOG4105CQB FAD linked oxidase domain protein D5F51_07960 ENOG4105KA0 thioesterase Superfamily protein D5F51_07970 ENOG4108Z4V iron-sulfur cluster assembly D5F51_07975 ENOG4105DIW FeS assembly protein SUFB D5F51_07980 ENOG4105C3K feS assembly ATPase SufC D5F51_07985 ENOG4105JRK feS assembly protein SufD D5F51_07995 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D5F51_08000 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D5F51_08005 ENOG4105KMX major outer membrane lipoprotein D5F51_08010 ENOG4105CA9 Pyruvate kinase D5F51_08030 ENOG4107QI1 Mate efflux family protein D5F51_08035 ENOG4108R6K riboflavin synthase, subunit alpha D5F51_08040 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D5F51_08045 ENOG4105CZQ inner membrane transport protein YdhC D5F51_08050 ENOG4105F52 Transcriptional regulator D5F51_08055 ENOG4105ETE Transcriptional regulator (LacI family D5F51_08065 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D5F51_08070 ENOG4105K4H Nlp p60 protein D5F51_08075 ENOG4105M2J Glutaredoxin D5F51_08080 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) D5F51_08085 ENOG4108UYE Lactoylglutathione lyase D5F51_08090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D5F51_08095 ENOG4108WUH Transcriptional regulator, TetR family D5F51_08100 ENOG4105DIJ Phosphoethanolamine transferase D5F51_08105 ENOG4105XZD Fe-S protein D5F51_08110 ENOG4107RGM aldo keto reductase D5F51_08115 ENOG4105DSW Fusaric acid resistance protein D5F51_08120 ENOG4105Y49 secretion protein, HlyD family D5F51_08130 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) D5F51_08135 ENOG4108XTF Outer Membrane Lipoprotein D5F51_08140 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D5F51_08145 ENOG410642K Lysozyme inhibitor D5F51_08150 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D5F51_08155 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D5F51_08165 ENOG4108K3A Glutathione S-transferase D5F51_08170 ENOG4108ZR5 Conserved Protein D5F51_08175 ENOG41069YE inner membrane protein yohC D5F51_08185 ENOG4105DUX Transporter D5F51_08190 ENOG4105DUM transcriptional regulator, lysR family D5F51_08195 ENOG4105Q4T oxidoreductase D5F51_08230 ENOG4108S1B Periplasmic chaperone protein D5F51_08235 ENOG4108D1K outer membrane usher protein D5F51_08240 ENOG4108JQ2 peptide transport system atp-binding protein D5F51_08245 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein D5F51_08250 ENOG4108EU3 peptide transport system, permease D5F51_08255 ENOG4108I5W peptide transport system, permease protein D5F51_08260 ENOG4108J59 Extracellular solute-binding protein, family 5 D5F51_08270 ENOG4105E51 psp operon transcriptional activator D5F51_08275 ENOG41087YS Phage shock protein A D5F51_08280 ENOG4105YYT phage shock protein B D5F51_08285 ENOG4105FM1 phage shock protein C D5F51_08295 ENOG4105CM6 amino acid regulated cytosolic protein D5F51_08300 ENOG4106K28 UPF0283 membrane protein D5F51_08320 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D5F51_08325 ENOG4107S8C mandelate racemase muconate lactonizing D5F51_08330 ENOG4105KXI murein peptide amidase A D5F51_08335 ENOG4107QSI ABC, transporter D5F51_08355 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) D5F51_08360 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C D5F51_08370 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) D5F51_08390 ENOG4105C5I Dehydrogenase D5F51_08395 ENOG4107H52 Dicarboxylate transport D5F51_08400 ENOG410689M (LipO)protein D5F51_08405 ENOG4105WXT Conserved Protein D5F51_08410 ENOG4105IE8 Alpha-ketoglutarate permease D5F51_08415 ENOG4105CMG Carbohydrate kinase D5F51_08420 ENOG4105DEI Mannitol dehydrogenase D5F51_08425 ENOG4105DKT Transcriptional regulator D5F51_08430 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D5F51_08435 ENOG4105CQ7 ATP-dependent helicase D5F51_08440 ENOG4105MRD Phage derived protein Gp49-like (DUF891) D5F51_08450 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap D5F51_08460 ENOG4105CTD carboxy-peptidase D5F51_08465 ENOG4105JJR Histidine kinase D5F51_08470 ENOG4107EXC regulatoR D5F51_08480 ENOG4105D5Q Arginine ornithine antiporter D5F51_08485 ENOG4105C5D exported protein D5F51_08495 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D5F51_08500 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D5F51_08505 ENOG4105Q9Y Universal stress protein D5F51_08510 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D5F51_08515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D5F51_08530 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) D5F51_08550 ENOG4108RVA ribokinase D5F51_08555 ENOG4105EDR glucose galactose transporter D5F51_08570 ENOG4105ETT transcriptional Regulator, LysR family D5F51_08580 ENOG4105PAD Hydrolase D5F51_08590 ENOG4105M71 acetolactate synthase 1 regulatory subunit D5F51_08595 ENOG4105C7K acetolactate synthase D5F51_08615 ENOG4105GQR Chaperone D5F51_08620 ENOG4105CW0 outer membrane usher protein D5F51_08630 ENOG4108YH7 hemolysin D5F51_08635 ENOG4108QZZ filamentous hemagglutinin D5F51_08635 ENOG4108QZZ filamentous hemagglutinin D5F51_08640 ENOG4108TC1 Transcriptional regulator D5F51_08675 ENOG4105FYV Amp nucleosidase D5F51_08695 ENOG4106V2I dimethylaminohydrolase D5F51_08700 ENOG4105E89 ABC transporter D5F51_08705 ENOG4105DSP amino acid AbC transporter D5F51_08715 ENOG4108RYR transcriptional regulator AsnC family D5F51_08725 ENOG4105CYM Glutathione S-transferase D5F51_08755 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_08760 ENOG4105EMU Dehydrogenase D5F51_08765 ENOG4105KK4 UPF0060 membrane protein D5F51_08770 ENOG4105M5Q UPF0482 protein D5F51_08775 ENOG4105KBG Protein of unknown function (DUF1161) D5F51_08790 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D5F51_08795 ENOG4105DAG ROK family D5F51_08800 ENOG4106NZI LysR family Transcriptional regulator D5F51_08805 ENOG4105D94 Major Facilitator Superfamily D5F51_08820 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) D5F51_08825 ENOG4108SVW integral membrane protein D5F51_08830 ENOG4105C9Q fumarate hydratase class II D5F51_08835 ENOG4105EIP mannose-6-phosphate isomerase D5F51_08840 ENOG4106J39 exported protein D5F51_08845 ENOG4107P2S Transcriptional regulator D5F51_08850 ENOG4105CI1 PTS System D5F51_08855 ENOG4105C87 Aminotransferase class I and II D5F51_08860 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D5F51_08865 ENOG4105DHU Bile acid D5F51_08870 ENOG4105D9R oxidoreductase D5F51_08880 ENOG4105CNN ABC, transporter D5F51_08890 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator D5F51_08900 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) D5F51_08905 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D5F51_08910 ENOG4108JJA ABC, transporter D5F51_08915 ENOG4105C42 Type I secretion membrane fusion protein (HlyD D5F51_08930 ENOG4105CKU formyltetrahydrofolate synthetase D5F51_08935 ENOG4105M9B inner membrane protein ydgK D5F51_08940 ENOG4105DGN Electron transport complex D5F51_08950 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) D5F51_08955 ENOG4105UEI Transcriptional Regulator AraC Family D5F51_08960 ENOG4105D6A Electron transport complex D5F51_08965 ENOG4108UQQ Electron transport complex D5F51_08975 ENOG4105CSM endonuclease III D5F51_08985 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit D5F51_08990 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) D5F51_08995 ENOG4105D22 carbon starvation protein D5F51_09000 ENOG4105VCD cytoplasmic protein D5F51_09005 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D5F51_09010 ENOG4105N2W Transcriptional regulator D5F51_09020 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D5F51_09025 ENOG41061RM osmotically inducible lipoprotein D5F51_09030 ENOG4108ZJT translation initiation factor, Sui1 D5F51_09035 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D5F51_09040 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction D5F51_09045 ENOG4105DKK Benzoate D5F51_09050 ENOG4108JCI Transcriptional regulator D5F51_09060 ENOG4105CFV Tetratricopeptide repeat protein D5F51_09065 ENOG4105Q4A inner membrane protein yciS D5F51_09070 ENOG4105EYK Phosphatidylglycerophosphatase B D5F51_09075 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) D5F51_09080 ENOG4107QM5 aconitate hydratase D5F51_09095 ENOG4107R11 Transcriptional regulator D5F51_09100 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D5F51_09110 ENOG4105RKX Protein of unknown function (DUF2498) D5F51_09115 ENOG4105ERU peptidase D5F51_09120 ENOG4105UBK short-chain dehydrogenase reductase D5F51_09125 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D5F51_09130 ENOG4105FE9 pseudouridine synthase D5F51_09155 ENOG4108Q9V regulatoR D5F51_09165 ENOG4107RTD sua5 ycio yrdc ywlc family protein D5F51_09170 ENOG4105DB7 PHP domain protein D5F51_09185 ENOG4105DDQ anthranilate synthase D5F51_09195 ENOG4105DK0 Indole-3-glycerol phosphate synthase D5F51_09200 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D5F51_09205 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D5F51_09215 ENOG4105EIF outer membrane protein W D5F51_09225 ENOG4108S3I UPF0259 membrane protein D5F51_09235 ENOG4107835 probably involved in intracellular septation (By similarity) D5F51_09240 ENOG4105NAU thioesterase Superfamily protein D5F51_09245 ENOG410822N TonB family D5F51_09250 ENOG4105K9H YciI-like protein D5F51_09275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D5F51_09285 ENOG4108JQ7 (ABC) transporter D5F51_09290 ENOG4105C3U ABC transporter D5F51_09295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5F51_09300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D5F51_09305 ENOG4107QSI ABC, transporter D5F51_09310 ENOG4107QSI ABC, transporter D5F51_09315 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D5F51_09325 ENOG4108EKI Dehydrogenase D5F51_09330 ENOG4107104 thymidine kinase D5F51_09345 ENOG4105C6Y Udp-glucose 6-dehydrogenase D5F51_09350 ENOG4105I93 response regulator D5F51_09355 ENOG4105D78 K07001 NTE family protein D5F51_09360 ENOG4105K5B UPF0225 protein D5F51_09365 ENOG4105CIY formyltetrahydrofolate deformylase D5F51_09395 ENOG4105CGK Exodeoxyribonuclease III D5F51_09400 ENOG4105M6F mutator MutT protein D5F51_09405 ENOG4105MTM Protein of unknown function (DUF1496) D5F51_09410 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D5F51_09420 ENOG41069NU Nitroreductase D5F51_09425 ENOG4105D07 Signal peptide peptidase, SppA D5F51_09430 ENOG4105HDK L-asparaginase D5F51_09435 ENOG4108RWI nicotinamidase D5F51_09440 ENOG4105VUT cytoplasmic protein D5F51_09455 ENOG4105DSB aldose 1-epimerase D5F51_09460 ENOG4105GNX MltA-interacting MipA family protein D5F51_09470 ENOG4105CYN Serine protein kinase D5F51_09475 ENOG4106AKX UPF0229 protein D5F51_09490 ENOG4105HEI LysR family (Transcriptional regulator D5F51_09495 ENOG4105EUB pirin domain protein D5F51_09500 ENOG4105BZU Histidine kinase D5F51_09505 ENOG4105CNH Multidrug resistance protein MdtL D5F51_09510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D5F51_09515 ENOG4105MWK D-amino acid dehydrogenase, small subunit D5F51_09520 ENOG4105ED1 spovr family D5F51_09525 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) D5F51_09530 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D5F51_09535 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) D5F51_09545 ENOG4108ZZ3 UPF0260 protein D5F51_09550 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase D5F51_09555 ENOG4105CVE Lytic murein transglycosylase D5F51_09570 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D5F51_09575 ENOG4107QMS site-determining protein D5F51_09580 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D5F51_09585 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) D5F51_09590 ENOG4105CEY Amp-dependent synthetase and ligase D5F51_09595 ENOG4105Y4Z Outer Membrane Lipoprotein D5F51_09600 ENOG41072GX Peptidase M22 Glycoprotease D5F51_09605 ENOG4105DVT helicase D5F51_09610 ENOG4105M4H endoribonuclease L-psp D5F51_09620 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) D5F51_09625 ENOG4108UHU Aldolase D5F51_09630 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D5F51_09635 ENOG4106KNT transcriptional regulator D5F51_09640 ENOG4105CA9 Pyruvate kinase D5F51_09645 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase D5F51_09650 ENOG4105DR5 peptidase D5F51_09655 ENOG4105NXV High-affinity zinc uptake system protein D5F51_09660 ENOG4105FDK ABC transporter D5F51_09665 ENOG4105FAV ABC, transporter D5F51_09670 ENOG4105DUX Transporter D5F51_09675 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D5F51_09690 ENOG4105CDY transcriptional regulatory protein D5F51_09695 ENOG4108TIT dATP pyrophosphohydrolase D5F51_09700 ENOG4105C9M aspartyl-trna synthetase D5F51_09710 ENOG4105D3W isochorismatase D5F51_09715 ENOG41081XQ Conserved Protein D5F51_09720 ENOG4105WJG Glutathione D5F51_09730 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) D5F51_09735 ENOG4106N3A copper homeostasis protein cutc D5F51_09740 ENOG4106ZCM YecM protein D5F51_09745 ENOG4105C75 arginyL-tRNA synthetase D5F51_09750 ENOG4105CJR Integral membrane protein (MviN D5F51_09755 ENOG4105EP9 oxidoreductase D5F51_09765 ENOG4105D9U N-acetyltransferase D5F51_09770 ENOG4105EV4 Multidrug resistance protein mdtH D5F51_09775 ENOG4105F3T (LipO)protein D5F51_09780 ENOG4107XHZ cytoplasmic chaperone TorD family protein D5F51_09785 ENOG4107SSZ Phosphatase D5F51_09790 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D5F51_09815 ENOG4105CHH sulfate transporter D5F51_09820 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D5F51_09825 ENOG41063JG Transcriptional regulator D5F51_09830 ENOG4108YY7 Invasion gene expression up-regulator SirB D5F51_09835 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D5F51_09840 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D5F51_09845 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D5F51_09850 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) D5F51_09860 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D5F51_09865 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria D5F51_09870 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D5F51_09880 ENOG4105C3G gtp-binding protein D5F51_09900 ENOG4108K5P (LipO)protein D5F51_09910 ENOG4108MEK Metal-binding protein YodA D5F51_09915 ENOG4108HWV )-transporter D5F51_09920 ENOG4105C2J ABC transporter D5F51_09930 ENOG41090B9 response to stress D5F51_09935 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) D5F51_09940 ENOG4105CZE histidine utilization repressor D5F51_09945 ENOG4105CI2 imidazolone-5-propionate hydrolase D5F51_09960 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) D5F51_09965 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) D5F51_09975 ENOG4105F4X arginine D5F51_09980 ENOG4105C8Y Acetylornithine aminotransferase D5F51_09990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D5F51_09995 ENOG4105C4M (Ubiquinol oxidase) subunit I D5F51_10000 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D5F51_10010 ENOG4105BZU Histidine kinase D5F51_10015 ENOG4107R11 Transcriptional regulator D5F51_10025 ENOG4105EWV Sodium calcium exchanger membrane region D5F51_10030 ENOG4105D5M phosphate starvation-inducible protein D5F51_10045 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD D5F51_10050 ENOG4105CND Glycosyl transferase, family 2 D5F51_10055 ENOG4107BJW polysaccharide deacetylase D5F51_10060 ENOG4108TUY outer membrane protein PgaA D5F51_10065 ENOG4105H1N peptidase, M24 D5F51_10090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D5F51_10100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D5F51_10115 ENOG4107SJW iron permease, FTR1 D5F51_10135 ENOG4105CSV Glutaminase D5F51_10140 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D5F51_10145 ENOG4105FB2 class II Aldolase D5F51_10150 ENOG4105G63 Type III effector Hrp-dependent D5F51_10155 ENOG4105MVE transcriptional regulator D5F51_10160 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D5F51_10165 ENOG4108MRH transcriptional regulatory protein D5F51_10175 ENOG4105C85 amino acid D5F51_10185 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase D5F51_10195 ENOG4106UW1 Major Facilitator superfamily D5F51_10200 ENOG4108HCJ Hydrolase D5F51_10205 ENOG4105D3G Pseudouridine synthase D5F51_10210 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme D5F51_10225 ENOG4105KD7 acetyltransferase D5F51_10270 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D5F51_10315 ENOG4105VZ1 Replication Protein D5F51_10335 ENOG4105ED4 portal protein D5F51_10475 ENOG4105ZTC transcriptional activator, Ogr delta D5F51_10495 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D5F51_10500 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D5F51_10505 ENOG4105WH1 Two component transcriptional regulator luxr family D5F51_10510 ENOG4105XVG cytoplasmic protein D5F51_10515 ENOG4105RA2 Membrane D5F51_10525 ENOG4105E5K Alpha-amylase D5F51_10540 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D5F51_10565 ENOG4105C85 amino acid D5F51_10575 ENOG4108V1U phospholipid-binding protein D5F51_10580 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) D5F51_10620 ENOG4105CK7 Sodium proline symporter D5F51_10625 ENOG4105C26 Dehydrogenase D5F51_10640 ENOG4105CDA abc transporter atp-binding protein D5F51_10645 ENOG4105E5Q amino acid AbC transporter D5F51_10650 ENOG4105EAB amino acid AbC transporter D5F51_10655 ENOG4105K6H D-cysteine desulfhydrase D5F51_10660 ENOG4108M9K flagella biosynthesis protein FliZ D5F51_10665 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D5F51_10675 ENOG4105DTS flagellar hook-associated D5F51_10680 ENOG4105MQ3 flagellar protein FliS D5F51_10685 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) D5F51_10695 ENOG4105DHT Metal Dependent Phosphohydrolase D5F51_10705 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling D5F51_10715 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D5F51_10720 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D5F51_10725 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D5F51_10730 ENOG41090PJ Flagellar assembly protein D5F51_10735 ENOG4108JIR Flagellum-specific ATP synthase D5F51_10740 ENOG4105GSA Flagellar export protein flij D5F51_10745 ENOG4105WF4 Flagellar hook-length control protein D5F51_10750 ENOG4107ZI8 flagellar basal body-associated protein flil D5F51_10755 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D5F51_10760 ENOG4105DD5 Flagellar motor switch protein D5F51_10770 ENOG4105CN7 Flagellar biosynthetic protein FliP D5F51_10775 ENOG4105VS8 Flagellar biosynthetic protein fliq D5F51_10780 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D5F51_10785 ENOG4105DTJ flagellar hook-associated protein D5F51_10790 ENOG4105E1Q flagellar hook-associated protein D5F51_10795 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D5F51_10810 ENOG4105CGA flagellar basal-body rod protein FlgG D5F51_10815 ENOG4108KPB Flagellar basal-body rod protein FlgF D5F51_10820 ENOG4105BZE flagellar hook protein, FlgE D5F51_10825 ENOG4105W00 Flagellar hook capping protein D5F51_10830 ENOG4108ZC9 flagellar basal-body rod protein flgc D5F51_10835 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D5F51_10840 ENOG4105CKS Flagella basal body P-ring formation protein flgA D5F51_10845 ENOG4105M9M anti-sigma28 factor FlgM D5F51_10850 ENOG4105QVD Flagella synthesis protein FlgN D5F51_10855 ENOG4105W13 flagellar protein D5F51_10860 ENOG4105D7B Flagellar biosynthesis protein flha D5F51_10865 ENOG4105D00 flagellar biosynthetic protein flhB D5F51_10870 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) D5F51_10875 ENOG4108VYJ response regulator receiver protein D5F51_10885 ENOG4105BZU Histidine kinase D5F51_10890 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_10895 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_10900 ENOG4108V3W Chemotaxis protein, CheW D5F51_10905 ENOG4105CBS Chea signal transduction histidine kinase D5F51_10910 ENOG4105ER2 Ompa motb domain protein D5F51_10915 ENOG4107RD7 Flagellar Motor Protein, MotA D5F51_10920 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region D5F51_10925 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) D5F51_10930 ENOG4108VA4 Universal stress protein D5F51_10935 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D5F51_10940 ENOG4105KT7 mgtC SapB transporter D5F51_10945 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_10950 ENOG4105VZF DsrB protein D5F51_10955 ENOG4105VEQ Cold shock protein D5F51_10960 ENOG4105ETE Transcriptional regulator (LacI family D5F51_10965 ENOG4105CNT hydrolase family 2 D5F51_10970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D5F51_10975 ENOG4105GSJ Inner membrane protein ylaC D5F51_10990 ENOG41061EV selenium-binding protein YdfZ D5F51_10995 ENOG4105D6F Phosphatase D5F51_11000 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D5F51_11010 ENOG41077RS Phosphatase D5F51_11015 ENOG4105E8V Alpha Beta Hydrolase Fold protein D5F51_11025 ENOG4108HPI phosphatidate Cytidylyltransferase D5F51_11030 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase D5F51_11040 ENOG4108Q9V regulatoR D5F51_11065 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) D5F51_11080 ENOG4105FDK ABC transporter D5F51_11110 ENOG4105C2C drug resistance transporter, Bcr CflA D5F51_11115 ENOG4105ENX hydrolase D5F51_11120 ENOG4105CPC Aldo Keto reductase D5F51_11130 ENOG4105GR3 Histidine kinase D5F51_11185 ENOG4107SET aldo keto reductase D5F51_11190 ENOG4105EQ2 LysR family Transcriptional regulator D5F51_11195 ENOG4105CGD Nad-dependent epimerase dehydratase D5F51_11205 ENOG4108Q9V regulatoR D5F51_11210 ENOG4105BZU Histidine kinase D5F51_11220 ENOG4108MQF Chaperone D5F51_11225 ENOG4105CW0 outer membrane usher protein D5F51_11270 ENOG4108TSE Transferase D5F51_11275 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D5F51_11285 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D5F51_11290 ENOG4107QPK )-transporter D5F51_11300 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase D5F51_11305 ENOG4105CHY citrate lyase, alpha D5F51_11310 ENOG4105CI0 Citrate lyase D5F51_11315 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) D5F51_11320 ENOG4105DUA (citrate (pro-3S)-lyase ligase D5F51_11325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D5F51_11330 ENOG4106YYS transcriptional regulatory protein D5F51_11335 ENOG4108KX4 response regulator D5F51_11340 ENOG4105BZU Histidine kinase D5F51_11345 ENOG4105CXY transporter D5F51_11350 ENOG4105C4Y ABC transporter D5F51_11355 ENOG4107RCV ABC transporter, permease D5F51_11360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D5F51_11370 ENOG4107R88 Chemotaxis protein (CheV) D5F51_11375 ENOG4105UQX Mate efflux family protein D5F51_11380 ENOG4105CDH Citrulline--aspartate ligase D5F51_11385 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) D5F51_11390 ENOG4108TGR phosphatase D5F51_11395 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) D5F51_11400 ENOG4108YZT Adenosylcobinamide kinase D5F51_11405 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D5F51_11415 ENOG4108V4M Cobalt abc transporter D5F51_11420 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) D5F51_11425 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) D5F51_11430 ENOG4105DVK Precorrin-2 c20-methyltransferase D5F51_11435 ENOG4107PPM cobalt chelatase D5F51_11440 ENOG4105QUC reductase D5F51_11445 ENOG4105E4R Precorrin-3B C17-methyltransferase D5F51_11450 ENOG4108P62 biosynthesis protein (CbiG) D5F51_11455 ENOG4105CIA precorrin-4 C(11)-methyltransferase D5F51_11460 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase D5F51_11465 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase D5F51_11470 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) D5F51_11475 ENOG41081F0 Precorrin-8x methylmutase D5F51_11480 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) D5F51_11485 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D5F51_11490 ENOG4107XVH Transcriptional regulator D5F51_11495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D5F51_11500 ENOG4105KNY Microcompartments protein D5F51_11505 ENOG4105EHR propanediol utilization protein pduB D5F51_11510 ENOG4105DMB glycerol dehydratase D5F51_11515 ENOG4105YCI dehydratase medium subunit D5F51_11520 ENOG4108ZFT Dehydratase small subunit D5F51_11525 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit D5F51_11535 ENOG4105KNY Microcompartments protein D5F51_11540 ENOG4105KNY Microcompartments protein D5F51_11545 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) D5F51_11555 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml D5F51_11565 ENOG4108EKI Dehydrogenase D5F51_11575 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) D5F51_11585 ENOG4105M3W utilization protein D5F51_11590 ENOG4105KTW ethanolamine utilization protein D5F51_11595 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D5F51_11600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D5F51_11605 ENOG4107QZB decarboxylase D5F51_11610 ENOG4105JZC GHMP kinase D5F51_11615 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D5F51_11620 ENOG4105C2J ABC transporter D5F51_11625 ENOG4105CNN ABC, transporter D5F51_11640 ENOG4105DR8 Membrane D5F51_11645 ENOG4105E4E Thioester reductase domain-containing protein D5F51_11650 ENOG4105CJB Exodeoxyribonuclease I D5F51_11655 ENOG4105CUB amino acid D5F51_11665 ENOG4107SCQ Iron-containing alcohol dehydrogenase D5F51_11670 ENOG4105C2J ABC transporter D5F51_11675 ENOG4105CNN ABC, transporter D5F51_11680 ENOG4108535 NAD dependent epimerase/dehydratase family D5F51_11690 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D5F51_11700 ENOG4105CIH Imidazole acetol-phosphate transaminase D5F51_11705 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D5F51_11710 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D5F51_11715 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D5F51_11720 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D5F51_11725 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D5F51_11730 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D5F51_11735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D5F51_11740 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D5F51_11755 ENOG4108DMA Nad-dependent epimerase dehydratase D5F51_11760 ENOG4105C0K Gdp-mannose 4,6-dehydratase D5F51_11775 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 D5F51_11795 ENOG4108TJN glycosyl transferase group 1 D5F51_11825 ENOG4105EE5 Membrane protein terC D5F51_11830 ENOG4105CEE C4-dicarboxylate transporter D5F51_11835 ENOG4108GAE asmA family D5F51_11850 ENOG4105D1F ATP-binding protein D5F51_11855 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D5F51_11875 ENOG4105E5W Transporter D5F51_11880 ENOG4105VAW lrga family D5F51_11885 ENOG41067MG lrgb family D5F51_11895 ENOG4107R1I NAD-dependent malic enzyme D5F51_11905 ENOG4107GZ4 SanA protein D5F51_11915 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) D5F51_11920 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) D5F51_11925 ENOG4108JPZ Monovalent cation H antiporter subunit D D5F51_11930 ENOG4107TDF Formate hydrogenlyase subunit 4 D5F51_11935 ENOG4105D65 subunit l D5F51_11940 ENOG4107WQX hydrogenase 4 membrane subunit D5F51_11945 ENOG4108JPZ Monovalent cation H antiporter subunit D D5F51_11950 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D5F51_11960 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit D5F51_11965 ENOG4105I6X formate hydrogenlyase maturation D5F51_11970 ENOG4108MG9 hydrogenase 3 maturation protease D5F51_11975 ENOG4108RC0 Electron transport protein D5F51_11980 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D5F51_11990 ENOG4105TMB Formate nitrite transporter D5F51_11995 ENOG4107SDZ Galactoside transport system permease protein mglC D5F51_12010 ENOG41060NJ transcriptional regulator D5F51_12015 ENOG4105DHF Membrane D5F51_12020 ENOG4105EUJ GTP cyclohydrolase i D5F51_12025 ENOG4105CBP Major Facilitator D5F51_12030 ENOG4105EGI Transcriptional regulator D5F51_12060 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D5F51_12070 ENOG4105CSH Transporter D5F51_12080 ENOG4105CVM Molybdenum cofactor synthesis domain protein D5F51_12085 ENOG4105D06 uba thif-type nad fad binding protein D5F51_12090 ENOG4108M1A Chitin-binding protein D5F51_12095 ENOG4105C5H ABC transporter D5F51_12115 ENOG4108T1M outer membrane protein x D5F51_12145 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) D5F51_12150 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction D5F51_12155 ENOG4105KSC Transcriptional regulator, TraR DksA family D5F51_12160 ENOG4107R0W ABC transporter D5F51_12165 ENOG4105E5Q amino acid AbC transporter D5F51_12170 ENOG4105CDA abc transporter atp-binding protein D5F51_12175 ENOG4107SDU Methyl-accepting chemotaxis D5F51_12180 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) D5F51_12185 ENOG4107XC4 flavin reductase domain protein, FMN-binding D5F51_12200 ENOG4108MTB glycosyl transferase family D5F51_12205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D5F51_12210 ENOG4105DVT helicase D5F51_12225 ENOG4105FDR Membrane D5F51_12245 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component D5F51_12250 ENOG4108IJ8 ABC transporter D5F51_12255 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component D5F51_12260 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system D5F51_12270 ENOG4107RJ5 oxidoreductase D5F51_12275 ENOG4105KHC sulfurtransferase D5F51_12280 ENOG4108IV0 ABC, transporter D5F51_12285 ENOG4105D5T phosphonate abc transporter D5F51_12290 ENOG4105CNN ABC, transporter D5F51_12295 ENOG4105C32 Amino acid ABC transporter (Permease) D5F51_12300 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein D5F51_12305 ENOG4108W15 Protein of unknown function (DUF1456) D5F51_12330 ENOG4105Y3U Transglycosylase-associated protein D5F51_12340 ENOG4105N1F Hnh endonuclease D5F51_12350 ENOG4105CXG d-lactate dehydrogenase D5F51_12355 ENOG41061WM D-Alanyl-D-Alanine D5F51_12365 ENOG4105CJW magnesium transporter D5F51_12375 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) D5F51_12380 ENOG4105C1J atp-dependent rna helicase D5F51_12385 ENOG4107MVR Transcriptional regulator D5F51_12390 ENOG4105D0S secretion protein (HlyD D5F51_12395 ENOG4105CJ1 ABC, transporter D5F51_12400 ENOG4107QWP ABC-2 type transporter D5F51_12405 ENOG4107QWP ABC-2 type transporter D5F51_12410 ENOG4105HFZ Membrane D5F51_12415 ENOG4108ZAF Molybdopterin D5F51_12420 ENOG4105M00 molybdopterin converting factor, subunit 1 D5F51_12425 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D5F51_12430 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D5F51_12435 ENOG4105CHW UPF0052 protein D5F51_12440 ENOG4105VYA Uncharacterized conserved protein (DUF2132) D5F51_12445 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D5F51_12455 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D5F51_12460 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D5F51_12465 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D5F51_12470 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D5F51_12480 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D5F51_12495 ENOG4108K4B hydrolase D5F51_12505 ENOG4105E0C molybdate abc transporter D5F51_12510 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D5F51_12515 ENOG410680R Protein of unknown function (DUF2592) D5F51_12525 ENOG4105F4R Transcriptional regulator mode D5F51_12530 ENOG4105DKW ABC transporter D5F51_12540 ENOG4105CMR udp-glucose 4-epimerase D5F51_12545 ENOG4105F0Z galactose-1-phosphate uridylyltransferase D5F51_12550 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) D5F51_12555 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D5F51_12565 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D5F51_12570 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D5F51_12575 ENOG4105PGM cation diffusion facilitator family transporter D5F51_12580 ENOG4106Z1T Nicotinamide Mononucleotide Transporter D5F51_12585 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D5F51_12620 ENOG4105UFD tol-pal system protein YbgF D5F51_12625 ENOG4105KCK Peptidoglycan-associated lipoprotein D5F51_12630 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D5F51_12635 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA D5F51_12635 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA D5F51_12640 ENOG4105M8F Biopolymer transport protein exbD tolR D5F51_12645 ENOG4105E02 MotA TolQ exbB proton channel D5F51_12650 ENOG4107YD3 Thioesterase D5F51_12655 ENOG4105KJB cyd operon protein YbgE D5F51_12665 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D5F51_12670 ENOG4105C4M (Ubiquinol oxidase) subunit I D5F51_12675 ENOG4105CGH 5'-nucleotidase D5F51_12680 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D5F51_12690 ENOG4105C7S Dehydrogenase D5F51_12695 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D5F51_12700 ENOG4105E33 succinate dehydrogenase D5F51_12710 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein D5F51_12715 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D5F51_12720 ENOG4105BZN citrate synthase D5F51_12725 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D5F51_12740 ENOG4105E7W lamb ycsf family protein D5F51_12745 ENOG4107R7A Allophanate hydrolase subunit 2 D5F51_12750 ENOG4105P4J Allophanate hydrolase, subunit 1 D5F51_12755 ENOG4107QNR UPF0135 protein D5F51_12760 ENOG4107RF4 Phosphodiesterase D5F51_12765 ENOG4105CVP deoxyribo-dipyrimidine photolyase D5F51_12770 ENOG4107SEY Conserved Protein D5F51_12775 ENOG4105XIQ Protein of unknown function (DUF2517) D5F51_12790 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D5F51_12795 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D5F51_12800 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) D5F51_12805 ENOG4105C08 Histidine kinase D5F51_12810 ENOG4105EEX Two component transcriptional regulator (Winged helix family D5F51_12820 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 D5F51_12830 ENOG4105EV9 Alpha Beta Hydrolase D5F51_12835 ENOG4105NNH LexA regulated protein D5F51_12840 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_12845 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) D5F51_12850 ENOG41090R7 Ferric uptake D5F51_12860 ENOG4105GX6 (LipO)protein D5F51_12870 ENOG4105CX6 glutaminyL-tRNA synthetase D5F51_12875 ENOG4105CI1 PTS System D5F51_12880 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D5F51_12885 ENOG4105CE4 GlcNAc 6-P deacetylase D5F51_12890 ENOG4105E2R ROK family D5F51_12895 ENOG4105D4U had-superfamily hydrolase, subfamily iia D5F51_12900 ENOG4105CAQ asparagine synthetase D5F51_12935 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D5F51_12940 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D5F51_12945 ENOG4105C9A Phoh family D5F51_12950 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D5F51_12955 ENOG4108JU5 Magnesium and cobalt efflux protein D5F51_12960 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D5F51_12970 ENOG4107RP9 extracellular solute-binding protein, family 3 D5F51_12975 ENOG4105EAD ABC transporter D5F51_12980 ENOG4105DRP amino acid AbC transporter D5F51_12985 ENOG4105CDA abc transporter atp-binding protein D5F51_12995 ENOG4107PAI alpha helical protein D5F51_13000 ENOG4105C8T Leucyl-tRNA synthetase D5F51_13005 ENOG4108U2H Rare lipoprotein B D5F51_13010 ENOG4105DJF DNA polymerase III, delta' subunit D5F51_13015 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D5F51_13020 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D5F51_13030 ENOG4105CJN penicillin-binding protein D5F51_13035 ENOG4105CNI cell division protein FtsW D5F51_13040 ENOG4105K6T rare lipoprotein A D5F51_13045 ENOG4105DZ1 carboxypeptidase D5F51_13050 ENOG4108Z43 UPF0250 protein D5F51_13055 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D5F51_13060 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D5F51_13065 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) D5F51_13070 ENOG4105BZU Histidine kinase D5F51_13075 ENOG4107Z6W Protein CrcB homolog D5F51_13080 ENOG4105VEQ Cold shock protein D5F51_13090 ENOG4108N8T regulatoR D5F51_13100 ENOG4108R1E Serine threonine protein phosphatase 1 D5F51_13120 ENOG4108JJ7 ABC transporter D5F51_13125 ENOG4105EZE Cupin 4 family protein D5F51_13175 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D5F51_13205 ENOG4108M6W surface presentation of antigens protein SpaS D5F51_13210 ENOG4108TN6 type iii secretion D5F51_13220 ENOG41075IY surface presentation of antigens protein SpaP D5F51_13240 ENOG4108JIR Flagellum-specific ATP synthase D5F51_13250 ENOG4108HR8 type iii secretion D5F51_13255 ENOG4108N8R Invasion protein D5F51_13260 ENOG4105K44 type iii secretion D5F51_13265 ENOG4105YY8 Transcriptional regulator D5F51_13275 ENOG4105Y7Q type iii secretion D5F51_13285 ENOG4108RBT type iii secretion D5F51_13405 ENOG4108KU3 Integrase D5F51_13415 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D5F51_13420 ENOG4105WQ3 Rna-binding protein D5F51_13425 ENOG4105C8N cysteinyl-tRNA synthetase D5F51_13430 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D5F51_13435 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) D5F51_13440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D5F51_13445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D5F51_13450 ENOG4105CV6 ABC transporter, permease D5F51_13455 ENOG4108I0Y (ABC) transporter D5F51_13460 ENOG4108UJV acyl-CoA thioesterase i D5F51_13465 ENOG4105E1F short-chain dehydrogenase reductase D5F51_13470 ENOG4107QR8 Thioredoxin D5F51_13475 ENOG4107QX8 SPFH domain, Band 7 family protein D5F51_13480 ENOG4105G5H Membrane D5F51_13485 ENOG4108Z6Z Transcriptional regulator D5F51_13490 ENOG4105C59 p-type ATPase D5F51_13495 ENOG4105MBR gumn family D5F51_13500 ENOG4108Z66 YbaK ebsC protein D5F51_13505 ENOG4105CGH 5'-nucleotidase D5F51_13510 ENOG4105EU0 Major facilitator Superfamily D5F51_13515 ENOG4105CKD glutathione-regulated potassium-efflux system protein D5F51_13520 ENOG4107RE1 Inosine-guanosine kinase D5F51_13525 ENOG4105CMR udp-glucose 4-epimerase D5F51_13540 ENOG4105ESV Glycosyl transferase, family 4 D5F51_13545 ENOG4107RJ7 Glycosyl transferase (Group 1 D5F51_13550 ENOG4105CG5 Glycosyl transferase (Group 1 D5F51_13555 ENOG4108SHN Glycosyl transferase, family 2 D5F51_13565 ENOG4105ER6 polysaccharide biosynthesis protein D5F51_13570 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D5F51_13575 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D5F51_13580 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D5F51_13585 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D5F51_13595 ENOG4107QMP dna polymerase iii subunits gamma and tau D5F51_13600 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D5F51_13605 ENOG4105WD1 Membrane D5F51_13615 ENOG4106428 Protein of unknown function (DUF2496) D5F51_13620 ENOG4105EGS Mechanosensitive ion channel D5F51_13625 ENOG41090EX DsrE family D5F51_13630 ENOG4108IG5 Transcriptional regulator D5F51_13635 ENOG4105C1P efflux transporter, rnd family, mfp subunit D5F51_13640 ENOG4105BZS acriflavin resistance protein D5F51_13645 ENOG4105RMW regulation of transcription, DNA-dependent D5F51_13650 ENOG4108626 Racemase D5F51_13655 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D5F51_13660 ENOG4105NRA 50s ribosomal protein l31 type b D5F51_13665 ENOG4105YK5 50S ribosomal protein L36 D5F51_13670 ENOG4105DSE periplasmic solute binding protein D5F51_13675 ENOG4105CC5 ABC transporter D5F51_13680 ENOG4105DIK (ABC) transporter D5F51_13690 ENOG4108UKR Biofilm formation regulator YbaJ D5F51_13695 ENOG4105KF5 hemolysin expression-modulating protein D5F51_13700 ENOG4105TNG K13735 adhesin invasin D5F51_13710 ENOG41080UX Methyltransferase D5F51_13715 ENOG4108MNP Glycoprotein polysaccharide metabolism D5F51_13720 ENOG4105C29 acyl-CoA thioesterase D5F51_13725 ENOG4105BZU Histidine kinase D5F51_13730 ENOG4108YZA Nitrogen regulatory protein pii D5F51_13735 ENOG4105BZ1 (ABC) transporter D5F51_13740 ENOG4105BZ1 (ABC) transporter D5F51_13745 ENOG4108XM1 transcriptional regulator AsnC family D5F51_13755 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) D5F51_13760 ENOG4108NFA extracellular solute-binding protein D5F51_13765 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D5F51_13770 ENOG4108TGP Thioesterase superfamily protein D5F51_13775 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein D5F51_13780 ENOG4105EIN peptidylprolyl cis-trans isomerase D5F51_13785 ENOG4105K70 DNA-binding protein D5F51_13790 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D5F51_13795 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D5F51_13805 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D5F51_13815 ENOG4105M85 Bola protein D5F51_13825 ENOG4105IEY (LipO)protein D5F51_13830 ENOG4105EYM Major Facilitator superfamily D5F51_13835 ENOG4108NFH Sugar hydrolase D5F51_13840 ENOG4105E2S oxidase) subunit II D5F51_13845 ENOG4105BZ9 Cytochrome C oxidase, subunit I D5F51_13850 ENOG4105CCU oxidase (Subunit III) D5F51_13855 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D5F51_13860 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D5F51_13865 ENOG4107RDB Major Facilitator D5F51_13870 ENOG4108VPT UPF0234 protein D5F51_13875 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D5F51_13880 ENOG4107S0N DJ-1 family D5F51_13885 ENOG4105CXY transporter D5F51_13890 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC D5F51_13900 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta D5F51_13905 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D5F51_13910 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D5F51_13915 ENOG4105CTB Polyprenyl synthetase D5F51_13920 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D5F51_13925 ENOG4108ZAI phosphatidylglycerophosphatase a D5F51_13930 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D5F51_13935 ENOG4107YIM Involved in the transcription termination process (By similarity) D5F51_13940 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D5F51_13945 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D5F51_13950 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D5F51_13960 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D5F51_13965 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D5F51_13970 ENOG4105VIE preprotein translocase, subunit YajC D5F51_13975 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D5F51_13985 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D5F51_13990 ENOG4108ZYK Acyl carrier protein phosphodiesterase D5F51_13995 ENOG4105D3R alkyl hydroperoxide reductase D5F51_14005 ENOG4105CHR reductase D5F51_14010 ENOG4107R28 alpha amylase, catalytic region D5F51_14015 ENOG4105C85 amino acid D5F51_14020 ENOG4105CWM branched-chain amino acid transport system II carrier protein D5F51_14030 ENOG4105BZU Histidine kinase D5F51_14035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D5F51_14040 ENOG4107RH8 nuclease SbcCD subunit D D5F51_14045 ENOG4105EYH Exonuclease D5F51_14050 ENOG4105DKQ ROK family D5F51_14055 ENOG4105DH7 May be involved in recombination (By similarity) D5F51_14060 ENOG4105NBK UPF0345 protein D5F51_14065 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D5F51_14070 ENOG4105E0K tonB-dependent siderophore receptor D5F51_14075 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D5F51_14090 ENOG4105F2W methyltransferase D5F51_14110 ENOG4105F8D glycoside hydrolase family 4 D5F51_14115 ENOG4105CI1 PTS System D5F51_14125 ENOG4105FDP GntR family transcriptional regulator D5F51_14130 ENOG4105D9N nucleoside D5F51_14135 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) D5F51_14140 ENOG4105DD7 kinase (PfkB family D5F51_14145 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D5F51_14150 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D5F51_14155 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) D5F51_14160 ENOG4105V1F Fermentation respiration switch protein D5F51_14165 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) D5F51_14170 ENOG4105CIN aminoacyl-histidine dipeptidase D5F51_14175 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D5F51_14190 ENOG4105WWK YheO domain protein D5F51_14195 ENOG4105CPF Cell wall formation (By similarity) D5F51_14205 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D5F51_14225 ENOG4105CJ2 (LipO)protein D5F51_14230 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) D5F51_14235 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D5F51_14240 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D5F51_14245 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D5F51_14250 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D5F51_14255 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D5F51_14260 ENOG4105F7V ErfK ybiS ycfS ynhG family protein D5F51_14265 ENOG4105E7A Glutamine amidotransferase D5F51_14275 ENOG4107QPN acyl-Coa dehydrogenase D5F51_14280 ENOG4106YJS accessory processing protein D5F51_14295 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) D5F51_14300 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) D5F51_14305 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) D5F51_14310 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) D5F51_14315 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) D5F51_14320 ENOG4105EXC Acyl-transferase D5F51_14340 ENOG4105RWQ Protein of unknown function (DUF1364) D5F51_14380 ENOG4107R08 Integrase D5F51_14385 ENOG4105CHM Aminotransferase D5F51_14400 ENOG4105C5R Aminotransferase D5F51_14410 ENOG4105E5Q amino acid AbC transporter D5F51_14415 ENOG4105E5Q amino acid AbC transporter D5F51_14430 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D5F51_14460 ENOG4105EQ0 Major Facilitator superfamily D5F51_14465 ENOG4108UMN azlc family D5F51_14470 ENOG4105ZED uncharacterized protein ygaH D5F51_14475 ENOG4105NTK Transcriptional repressor Mpra D5F51_14480 ENOG4105ETP RND efflux system, outer membrane lipoprotein D5F51_14485 ENOG4105CW7 secretion protein, HlyD family D5F51_14490 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_14495 ENOG4105EIB trna rrna methyltransferase D5F51_14500 ENOG4105K63 Thioredoxin D5F51_14505 ENOG4106IUH DTW domain containing protein D5F51_14510 ENOG4105CD5 CoA-binding domain protein D5F51_14515 ENOG4105JIM Phosphatidylserine synthase D5F51_14520 ENOG4105T42 (LipO)protein D5F51_14555 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5F51_14560 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D5F51_14565 ENOG4105C34 Pseudouridine synthase D5F51_14575 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D5F51_14580 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA D5F51_14585 ENOG4105CQC Prephenate dehydratase D5F51_14595 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D5F51_14600 ENOG4108NEV two component transcriptional regulator, LytTR family D5F51_14605 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D5F51_14610 ENOG4108NE3 Salt-induced outer membrane protein D5F51_14615 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D5F51_14620 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D5F51_14625 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D5F51_14630 ENOG4105K5M 30s ribosomal protein S16 D5F51_14635 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D5F51_14640 ENOG4106KVJ cytochrome C assembly protein D5F51_14645 ENOG4108JU6 CBS domain protein D5F51_14650 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) D5F51_14655 ENOG4105D9M gamma-glutamylcysteine synthetase D5F51_14660 ENOG4105W39 Membrane D5F51_14665 ENOG4107VXZ Hydrolase D5F51_14695 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D5F51_14700 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D5F51_14705 ENOG4105Y3E Modulates RecA activity (By similarity) D5F51_14710 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D5F51_14735 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D5F51_14740 ENOG4108IUS Transketolase D5F51_14745 ENOG4108HHA Transketolase D5F51_14750 ENOG4105CNN ABC, transporter D5F51_14755 ENOG4105C2J ABC transporter D5F51_14765 ENOG4105ETE Transcriptional regulator (LacI family D5F51_14770 ENOG4108NEM leader-binding protein dmsD D5F51_14775 ENOG4107KGK dmso reductase anchor subunit D5F51_14780 ENOG4105QAX Iron-sulfur D5F51_14785 ENOG4107QY8 reductase D5F51_14790 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D5F51_14795 ENOG4105E98 transcriptional regulator DeoR family D5F51_14805 ENOG4105C2J ABC transporter D5F51_14810 ENOG4105CNN ABC, transporter D5F51_14820 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase D5F51_14825 ENOG4105CMG Carbohydrate kinase D5F51_14830 ENOG4107GFK fumarate D5F51_14840 ENOG4105C32 Amino acid ABC transporter (Permease) D5F51_14845 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D5F51_14850 ENOG4108IUZ ABC transporter D5F51_14855 ENOG4108IV0 ABC, transporter D5F51_14880 ENOG4105DKT Transcriptional regulator D5F51_14885 ENOG4105CHR reductase D5F51_14890 ENOG4108XCU pts system D5F51_14895 ENOG4105KPI PTS system sorbose subfamily IIB component D5F51_14900 ENOG4105ETZ PTS System D5F51_14905 ENOG4105F3R pts system mannose fructose sorbose family iid D5F51_14910 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein D5F51_14915 ENOG4105YVS arsR family transcriptional regulator D5F51_14920 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D5F51_14925 ENOG4105DFH Transport of potassium into the cell (By similarity) D5F51_14945 ENOG4105CDA abc transporter atp-binding protein D5F51_14955 ENOG4105E5Q amino acid AbC transporter D5F51_14960 ENOG4105EAB amino acid AbC transporter D5F51_14985 ENOG4105BZC d-serine deaminase D5F51_14990 ENOG4105C6Z Gluconate D5F51_14995 ENOG4105W8I Transcriptional regulator D5F51_15000 ENOG4108JQ7 (ABC) transporter D5F51_15010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5F51_15015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D5F51_15020 ENOG4105DEF Extracellular solute-binding protein, family 5 D5F51_15025 ENOG4105CXK mandelate racemase muconate lactonizing D5F51_15030 ENOG4105CA0 peroxidase D5F51_15035 ENOG4105CIH Imidazole acetol-phosphate transaminase D5F51_15040 ENOG4105E89 ABC transporter D5F51_15045 ENOG4105CHR reductase D5F51_15060 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D5F51_15065 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D5F51_15070 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D5F51_15075 ENOG4105DJY efflux transporter, rnd family, mfp subunit D5F51_15080 ENOG4108JJA ABC, transporter D5F51_15090 ENOG4108Z33 Thiol disulfide Interchange Protein D5F51_15105 ENOG4105H8W Fimbrial protein D5F51_15110 ENOG4105NEV Fimbrial D5F51_15120 ENOG4108FZ9 Chaperone D5F51_15125 ENOG4106PG1 outer membrane usher protein D5F51_15175 ENOG4105D5K Hemolysin activator protein D5F51_15205 ENOG4105CKT filamentous hemagglutinin D5F51_15220 ENOG4106B0W Curli production assembly transport component CsgG D5F51_15230 ENOG4107Y60 (LipO)protein D5F51_15245 ENOG4105CW0 outer membrane usher protein D5F51_15250 ENOG4108VCD Chaperone D5F51_15255 ENOG4105US4 fimbrial-like protein yfcP D5F51_15260 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D5F51_15270 ENOG4105NTW Transcriptional regulator D5F51_15280 ENOG4105CS2 ec 3.2.1.21 D5F51_15290 ENOG4105DDV Transcriptional regulator (LacI family D5F51_15295 ENOG4108YYC ycei family D5F51_15300 ENOG4105DS1 cytochrome b561 D5F51_15305 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D5F51_15320 ENOG4105DHJ ABC, transporter D5F51_15345 ENOG4105CUB amino acid D5F51_15350 ENOG4105CVE Lytic murein transglycosylase D5F51_15365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D5F51_15370 ENOG4105E82 cytochrome subunit of dehydrogenase D5F51_15380 ENOG4105TW1 Carbohydrate-selective porin OprB D5F51_15385 ENOG4105CS2 ec 3.2.1.21 D5F51_15400 ENOG4107QY8 reductase D5F51_15405 ENOG4105QAX Iron-sulfur D5F51_15410 ENOG4107KGK dmso reductase anchor subunit D5F51_15415 ENOG4108NEM leader-binding protein dmsD D5F51_15425 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin D5F51_15435 ENOG4108VKM cytochrome b561 D5F51_15440 ENOG4105CHM Aminotransferase D5F51_15450 ENOG41072TH Protein of unknown function (DUF1479) D5F51_15455 ENOG4108HRK Histidine kinase D5F51_15460 ENOG4105DY9 regulatoR D5F51_15465 ENOG4105FCD Major Facilitator D5F51_15470 ENOG4105CHC glucokinase (EC 2.7.1.2) D5F51_15480 ENOG4105C5Q Transcriptional regulator D5F51_15485 ENOG4107RA9 decarboxylase D5F51_15490 ENOG4105CPC Aldo Keto reductase D5F51_15500 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) D5F51_15505 ENOG4105D9N nucleoside D5F51_15530 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D5F51_15560 ENOG4105VRT cytoplasmic protein D5F51_15565 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D5F51_15580 ENOG4105C6T cysteine synthase D5F51_15585 ENOG4105KZ7 phosphocarrier protein hpr D5F51_15590 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D5F51_15595 ENOG4105C5Y PTS System D5F51_15600 ENOG4105E0F Histidine kinase D5F51_15605 ENOG4105E3W Two component transcriptional regulator (Winged helix family D5F51_15610 ENOG4105DJY efflux transporter, rnd family, mfp subunit D5F51_15620 ENOG4105C6T cysteine synthase D5F51_15630 ENOG4105ECW sulfate abc transporter D5F51_15635 ENOG4108I5D sulfate abc transporter D5F51_15640 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein D5F51_15650 ENOG4105QEK Transcriptional regulator D5F51_15655 ENOG4108R66 Conserved Protein D5F51_15675 ENOG4105EZR dyp-type peroxidase family protein D5F51_15680 ENOG4105E7K (LipO)protein D5F51_15685 ENOG4105H4F exported protein D5F51_15695 ENOG4105CHR reductase D5F51_15700 ENOG4105KHC sulfurtransferase D5F51_15715 ENOG4108NQD D5F51_15720 ENOG4105CNN ABC, transporter D5F51_15730 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D5F51_15735 ENOG4108R6G acetyltransferase D5F51_15740 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D5F51_15750 ENOG4105C6K Malic enzyme D5F51_15755 ENOG4107VIJ nudix hydrolase D5F51_15760 ENOG4105CUW cytochrome C-TYPE protein D5F51_15765 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) D5F51_15770 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D5F51_15775 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase D5F51_15785 ENOG4105WH1 Two component transcriptional regulator luxr family D5F51_15795 ENOG4105BZS acriflavin resistance protein D5F51_15805 ENOG4105KUZ arsenate reductase D5F51_15810 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D5F51_15820 ENOG4105XYK UPF0370 protein D5F51_15825 ENOG4106KED esterase YpfH D5F51_15830 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) D5F51_15835 ENOG4108VMM UPF0756 membrane protein D5F51_15840 ENOG4105CGZ zinc metallopeptidase D5F51_15845 ENOG4105C8V SAICAR synthetase D5F51_15850 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D5F51_15855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D5F51_15860 ENOG4105RH4 Glycine cleavage system transcriptional repressor D5F51_15865 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D5F51_15870 ENOG4105C02 permease D5F51_15875 ENOG4105ERG peptidase m48, ste24p D5F51_15880 ENOG4105K89 arsenate reductase D5F51_15885 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) D5F51_15890 ENOG4105C2W permease D5F51_15895 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D5F51_15900 ENOG4105CXB phosphoribosylaminoimidazole synthetase D5F51_15905 ENOG4108V3E phosphoribosylglycinamide formyltransferase D5F51_15910 ENOG4108MK9 spermidine N(1)-acetyltransferase D5F51_15920 ENOG4105E2Z phosphate ABC transporter (Permease D5F51_15925 ENOG4105C8U phosphate abc transporter D5F51_15930 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D5F51_15935 ENOG4105C9X ppx gppa phosphatase D5F51_15945 ENOG4105CJW magnesium transporter D5F51_15950 ENOG4105BZU Histidine kinase D5F51_15955 ENOG4105R8A Heat shock protein D5F51_15965 ENOG4108VCD Chaperone D5F51_15970 ENOG4105CW0 outer membrane usher protein D5F51_15980 ENOG4105ENT Efflux transporter rnd family, mfp subunit D5F51_15990 ENOG4105BZS acriflavin resistance protein D5F51_15995 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_16000 ENOG4105EB3 Histidine kinase D5F51_16005 ENOG4105E3W Two component transcriptional regulator (Winged helix family D5F51_16010 ENOG4105KWI UPF0339 protein D5F51_16015 ENOG4105CFP Peptidase U32 D5F51_16020 ENOG4107TE5 Lipid kinase D5F51_16025 ENOG410787A Pts system, glucitol sorbitol-specific D5F51_16030 ENOG4105DZY Pts system, glucitol sorbitol-specific D5F51_16035 ENOG4105VI0 Pts system, glucitol sorbitol-specific D5F51_16040 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase D5F51_16045 ENOG4105J92 DNA-binding transcriptional activator GutM D5F51_16050 ENOG410804X Transcriptional regulator D5F51_16065 ENOG4108ZGU inhibitor of vertebrate lysozyme D5F51_16075 ENOG4105DWF phosphomethylpyrimidine kinase D5F51_16090 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D5F51_16095 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D5F51_16100 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D5F51_16105 ENOG4105VPD cellular component movement D5F51_16115 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D5F51_16120 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D5F51_16125 ENOG4105N21 Membrane D5F51_16130 ENOG4105CUT histidyl-tRNA synthetase D5F51_16135 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D5F51_16140 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) D5F51_16150 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D5F51_16165 ENOG4108JQB penicillin-binding protein 1C D5F51_16170 ENOG4105DN3 alpha-2-macroglobulin domain protein D5F51_16185 ENOG4105YYA enhanced serine sensitivity protein SseB D5F51_16195 ENOG4105WVQ Fe-S assembly protein IscX D5F51_16200 ENOG4108ZIT Ferredoxin, 2FE-2S D5F51_16205 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB D5F51_16210 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) D5F51_16225 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D5F51_16230 ENOG4105C3J Cysteine desulfurase D5F51_16235 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D5F51_16240 ENOG4105CVS RNA methyltransferase TrmH family, group 1 D5F51_16250 ENOG4105D7X high-affinity nickel-transporter D5F51_16255 ENOG41065CD Exported protein D5F51_16260 ENOG4108MN2 Stationary phase inducible protein CsiE D5F51_16265 ENOG4105D8G Major Facilitator superfamily D5F51_16270 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D5F51_16275 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D5F51_16280 ENOG4108M21 D5F51_16285 ENOG4105RMW regulation of transcription, DNA-dependent D5F51_16290 ENOG4108626 Racemase D5F51_16295 ENOG41080QX K07048 phosphotriesterase-related protein D5F51_16300 ENOG4105MUZ Protein of unknown function DUF2620 D5F51_16305 ENOG4106M0N transport system permease protein D5F51_16310 ENOG4108YZA Nitrogen regulatory protein pii D5F51_16315 ENOG4105C4K Nad synthetase D5F51_16320 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D5F51_16325 ENOG4108SKK alpha helix protein D5F51_16330 ENOG4107WP9 Histidine kinase D5F51_16350 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) D5F51_16355 ENOG4108Z6B deaminase D5F51_16365 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB D5F51_16375 ENOG4106G6Q Transcriptional regulator D5F51_16380 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D5F51_16385 ENOG4107EFN gluconate transport system permease 3 D5F51_16390 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D5F51_16395 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D5F51_16400 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) D5F51_16405 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D5F51_16415 ENOG4105C3F Signal peptidase i D5F51_16420 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D5F51_16430 ENOG4105WMJ Positive regulator of sigma E, RseC MucC D5F51_16440 ENOG41069PW sigma-e factor negative regulatory protein D5F51_16450 ENOG4108IYU L-aspartate oxidase D5F51_16455 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D5F51_16460 ENOG4105C1J atp-dependent rna helicase D5F51_16475 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) D5F51_16480 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D5F51_16485 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D5F51_16490 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D5F51_16495 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D5F51_16500 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D5F51_16510 ENOG4108Z1B Cyclase dehydrase D5F51_16525 ENOG4105DFP Integrase D5F51_16640 ENOG4105CW0 outer membrane usher protein D5F51_16645 ENOG4108VEV chaperone D5F51_16655 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5F51_16705 ENOG4108N8T regulatoR D5F51_16715 ENOG410901P UPF0249 protein D5F51_16720 ENOG4105EZV Transcriptional regulator D5F51_16725 ENOG4105VCP PTS System D5F51_16730 ENOG4105CS2 ec 3.2.1.21 D5F51_16735 ENOG4105CK1 PTS System D5F51_16740 ENOG4105VZJ PTS System D5F51_16745 ENOG4105D8V Glucose sorbosone dehydrogenase D5F51_16750 ENOG4105CPC Aldo Keto reductase D5F51_16760 ENOG41086WQ Protein CrcB homolog D5F51_16765 ENOG4107SVH Potassium channel protein D5F51_16770 ENOG4105XXV Acid-resistance protein D5F51_16785 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D5F51_16790 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) D5F51_16805 ENOG4105CQM Urea amidohydrolase subunit alpha D5F51_16825 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) D5F51_16835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5F51_16845 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein D5F51_16885 ENOG4108SAJ Protein of unknown function (DUF1198) D5F51_16890 ENOG4108WMJ Protein of unknown function (DUF2002) D5F51_16905 ENOG4105D7X high-affinity nickel-transporter D5F51_16910 ENOG4105TNS Conserved Protein D5F51_16915 ENOG4105WAZ (Glutaredoxin-like protein) NrdH D5F51_16920 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) D5F51_16930 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D5F51_16935 ENOG4108IJ7 Glycine betaine D5F51_16940 ENOG4108HQS Glycine betaine D5F51_16945 ENOG4105GIJ Glycine betaine D5F51_16955 ENOG4108JDX DNA polymerase iii, epsilon subunit D5F51_16965 ENOG4105D1A Methyltransferase D5F51_16970 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D5F51_16975 ENOG4105E9H Lytic Murein transglycosylase D5F51_16980 ENOG4107NA1 Endonuclease Exonuclease phosphatase D5F51_16985 ENOG4105F27 Major Facilitator D5F51_16990 ENOG4105HEI LysR family (Transcriptional regulator D5F51_16995 ENOG4105CV8 reductase D5F51_17035 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D5F51_17045 ENOG4108UMI ABC transporter, permease D5F51_17050 ENOG4105D01 (LipO)protein D5F51_17055 ENOG4108R8X outer membrane lipoprotein D5F51_17060 ENOG4108R96 Methyltransferase, YaeB family D5F51_17065 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D5F51_17070 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion D5F51_17075 ENOG4108YZN class I peptide chain release factor D5F51_17080 ENOG4108VWS Yaeq family D5F51_17085 ENOG4105W1I UPF0253 protein D5F51_17090 ENOG4105M1T rho-binding antiterminator D5F51_17095 ENOG4105N7H Cytochrome D5F51_17100 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D5F51_17105 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D5F51_17125 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D5F51_17130 ENOG4105C0B DNA polymerase III (alpha subunit) D5F51_17135 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D5F51_17140 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D5F51_17145 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D5F51_17150 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D5F51_17155 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D5F51_17160 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) D5F51_17170 ENOG4105DZP Membrane-associated zinc metalloprotease D5F51_17175 ENOG4105KNE Phosphatidate cytidylyltransferase D5F51_17180 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D5F51_17185 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D5F51_17195 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D5F51_17200 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D5F51_17205 ENOG4105CE9 30S ribosomal protein S2 D5F51_17215 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D5F51_17220 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D5F51_17225 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D5F51_17230 ENOG4108T8E UPF0325 protein D5F51_17235 ENOG4105QDK Flavodoxin D5F51_17240 ENOG4105DR9 pseudouridine synthase D5F51_17245 ENOG4105WP7 tRNA pseudouridine synthase C D5F51_17250 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) D5F51_17255 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D5F51_17260 ENOG4105EWT decarboxylase family D5F51_17265 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease D5F51_17270 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) D5F51_17275 ENOG4105M08 Membrane D5F51_17280 ENOG4105ETT transcriptional Regulator, LysR family D5F51_17285 ENOG4105M5B (LipO)protein D5F51_17290 ENOG4105C9B Cysteine desulfurase D5F51_17295 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D5F51_17300 ENOG4105CUZ uba thif-type nad fad binding protein D5F51_17305 ENOG4105CA3 membrane-bound lytic murein transglycosylase D5F51_17325 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D5F51_17330 ENOG4107QZM n-acetylglutamate synthase D5F51_17335 ENOG4107QYX exodeoxyribonuclease v alpha D5F51_17340 ENOG4107QKA exodeoxyribonuclease V beta D5F51_17345 ENOG4107QXK peptidase D5F51_17350 ENOG4105DSY exodeoxyribonuclease V, gamma D5F51_17355 ENOG4105RVB Prepilin peptidase dependent protein c D5F51_17380 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D5F51_17385 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase D5F51_17390 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D5F51_17400 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) D5F51_17405 ENOG4105EE5 Membrane protein terC D5F51_17410 ENOG4105CPC Aldo Keto reductase D5F51_17415 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) D5F51_17420 ENOG4105CEY Amp-dependent synthetase and ligase D5F51_17430 ENOG41060NJ transcriptional regulator D5F51_17435 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D5F51_17440 ENOG4105RQF LysR family Transcriptional regulator D5F51_17445 ENOG4105F27 Major Facilitator D5F51_17450 ENOG4105EJC lysr family transcriptional regulator D5F51_17505 ENOG4108VAU general secretion pathway protein G D5F51_17510 ENOG4105D7Q type ii secretion system D5F51_17515 ENOG4107QHF type ii secretion system protein e D5F51_17580 ENOG4105C4R Atp-dependent dna helicase D5F51_17585 ENOG4105DFP Integrase D5F51_17595 ENOG4105CRK lysyL-tRNA synthetase D5F51_17605 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D5F51_17610 ENOG4105T95 Thiol disulfide interChange protein D5F51_17615 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D5F51_17620 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) D5F51_17625 ENOG4105CT7 inner membrane cred family protein D5F51_17630 ENOG4105EB3 Histidine kinase D5F51_17635 ENOG4105E3W Two component transcriptional regulator (Winged helix family D5F51_17645 ENOG4105Y75 tpr repeat protein D5F51_17650 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) D5F51_17655 ENOG4108UT2 hemolysin iii D5F51_17665 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D5F51_17675 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D5F51_17680 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D5F51_17685 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D5F51_17690 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D5F51_17695 ENOG4105D0A hydroxylase D5F51_17700 ENOG4107RAQ aminopeptidase D5F51_17705 ENOG4105E07 UPF0149 protein D5F51_17710 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) D5F51_17720 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D5F51_17725 ENOG4108JQ1 Dehydrogenase D5F51_17730 ENOG4105E66 phosphoriboisomerase A D5F51_17735 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) D5F51_17740 ENOG4105MPN Membrane D5F51_17745 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D5F51_17750 ENOG4105D64 Mechanosensitive ion channel D5F51_17760 ENOG4105D2N Aldolase D5F51_17765 ENOG4105BZA Phosphoglycerate kinase D5F51_17770 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D5F51_17780 ENOG4105CV1 Transketolase (EC 2.2.1.1) D5F51_17785 ENOG4108K0D peptidase, M48 D5F51_17795 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) D5F51_17815 ENOG41080HT Transcriptional regulator, arsr family D5F51_17820 ENOG4105GPY SprT protein D5F51_17825 ENOG4105RWS endonuclease I D5F51_17830 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D5F51_17835 ENOG4105D7Z glutathione synthase D5F51_17840 ENOG4108UJU UPF0301 protein D5F51_17845 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D5F51_17850 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) D5F51_17860 ENOG4105CZX twitching motility protein D5F51_17865 ENOG4105DFA alanine racemase domain protein D5F51_17870 ENOG4105II7 pyrroline-5-carboxylate reductase D5F51_17875 ENOG4108VIA integral membrane protein D5F51_17880 ENOG4105VZ9 UPF0235 protein D5F51_17885 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D5F51_17890 ENOG4105CSA Coproporphyrinogen iii oxidase D5F51_17895 ENOG4105K33 Periplasmic Protein D5F51_17900 ENOG4105CSV Glutaminase D5F51_17905 ENOG41090ED Protein with unknown function (DUF469) D5F51_17915 ENOG4105C0R drug resistance transporter emrb qaca subfamily D5F51_17920 ENOG4105JQN Transcriptional regulator D5F51_17925 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D5F51_17930 ENOG4105CEN a g-specific adenine glycosylase D5F51_17935 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) D5F51_17940 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D5F51_17950 ENOG4105CXN decarboxylase D5F51_17990 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation D5F51_17995 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D5F51_18150 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5F51_18160 ENOG4108ZG0 Ompa motb domain protein D5F51_18220 ENOG4107QHF type ii secretion system protein e D5F51_18340 ENOG4105K5T PilT protein D5F51_18395 ENOG4108UUM single-stranded DNA-binding protein D5F51_18405 ENOG4108IYH Dna topoisomerase D5F51_18435 ENOG4105KSC Transcriptional regulator, TraR DksA family D5F51_18445 ENOG4105CDU Replicative dna helicase D5F51_18455 ENOG4105EZN Cobyrinic acid ac-diamide synthase D5F51_18480 ENOG41090KR LysR family transcriptional Regulator D5F51_18575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D5F51_18585 ENOG4108ZG0 Ompa motb domain protein D5F51_18610 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D5F51_18645 ENOG4108TN6 type iii secretion D5F51_18655 ENOG41075IY surface presentation of antigens protein SpaP D5F51_18675 ENOG4108JIR Flagellum-specific ATP synthase D5F51_18700 ENOG4105X27 type iii secretion D5F51_18705 ENOG4105K44 type iii secretion D5F51_18710 ENOG4108KB1 transcriptional regulator, arac family D5F51_18730 ENOG4108RBT type iii secretion D5F51_18780 ENOG4108FKE two-component system sensor kinase D5F51_18810 ENOG4107QHF type ii secretion system protein e D5F51_18820 ENOG4108VAU general secretion pathway protein G D5F51_18830 ENOG4105X5Z General secretion pathway protein I D5F51_18855 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) D5F51_18860 ENOG4105XQF Lipoprotein D5F51_18865 ENOG4108M1A Chitin-binding protein D5F51_18900 ENOG4108MI0 Resistance protein D5F51_18905 ENOG4105J12 Multidrug resistance protein mdtN D5F51_18925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D5F51_18930 ENOG4108IPW abc transporter atp-binding protein D5F51_18935 ENOG4105CM4 permease protein D5F51_18950 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D5F51_18965 ENOG4105ETE Transcriptional regulator (LacI family D5F51_18975 ENOG4105EAM Na Pi-cotransporter D5F51_18990 ENOG4105CSH Transporter D5F51_19010 ENOG4105EJC lysr family transcriptional regulator D5F51_19015 ENOG4106DSS Tartrate dehydratase subunit alpha D5F51_19020 ENOG4107GFK fumarate D5F51_19025 ENOG4107QPK )-transporter D5F51_19055 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase D5F51_19060 ENOG4105C8H hydrogenase maturation protein Hypf D5F51_19065 ENOG4105C45 hydrogenase expression formation protein (HypE) D5F51_19070 ENOG4105CQS hydrogenase expression formation protein HypD D5F51_19075 ENOG41082MF Hydrogenase assembly chaperone hypC hupF D5F51_19080 ENOG4107RSS Hydrogenase accessory protein HypB D5F51_19085 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) D5F51_19090 ENOG4108WGS hydrogenase 2-specific chaperone D5F51_19095 ENOG4108USZ hydrogenase D5F51_19100 ENOG4105DPX Hydrogenase, large subunit D5F51_19105 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit D5F51_19110 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D5F51_19115 ENOG4105E3S small subunit D5F51_19120 ENOG4108XTF Outer Membrane Lipoprotein D5F51_19150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D5F51_19155 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_19160 ENOG4105EXW epimerase dehydratase D5F51_19165 ENOG4105CSP Major Facilitator Superfamily D5F51_19170 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D5F51_19175 ENOG4105WQI isochorismatase D5F51_19180 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D5F51_19185 ENOG4105E4F Isochorismate synthase D5F51_19190 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein D5F51_19200 ENOG4105DQ5 transport system permease protein D5F51_19205 ENOG4105TVJ transport system, permease D5F51_19210 ENOG4105E0A ABC, transporter D5F51_19215 ENOG4105CEY Amp-dependent synthetase and ligase D5F51_19230 ENOG4105E0K tonB-dependent siderophore receptor D5F51_19240 ENOG410624V efflux system protein D5F51_19250 ENOG4105EP1 Efflux transporter rnd family, mfp subunit D5F51_19255 ENOG4108IJF Heavy metal efflux pump, CzcA D5F51_19330 ENOG4108ZZF transport protein (ExbD) D5F51_19335 ENOG4105CWK Biopolymer transport protein, ExbB D5F51_19340 ENOG4105C28 cystathionine D5F51_19345 ENOG4108K81 inner membrane protein YghB D5F51_19350 ENOG4105CF7 AraC family transcriptional regulator D5F51_19355 ENOG4108I6A alcohol dehydrogenase D5F51_19360 ENOG4105CV8 reductase D5F51_19370 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) D5F51_19375 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase D5F51_19380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5F51_19385 ENOG4105NF4 modulator of drug activity D5F51_19390 ENOG4105HEI LysR family (Transcriptional regulator D5F51_19395 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5F51_19400 ENOG4105IPS esterase D5F51_19405 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D5F51_19410 ENOG4108SX3 cytoplasmic protein D5F51_19415 ENOG41087AY ADP-Ribose pyrophosphatase D5F51_19420 ENOG4105DFG type I secretion outer membrane protein D5F51_19430 ENOG4106032 Glutathionylspermidine synthase D5F51_19435 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D5F51_19440 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D5F51_19445 ENOG4105W0Z cytoplasmic protein D5F51_19450 ENOG4105DVH amino acid D5F51_19455 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D5F51_19460 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D5F51_19465 ENOG4105I7R Adenylate cyclase D5F51_19470 ENOG4106MWK domain protein D5F51_19475 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D5F51_19480 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D5F51_19485 ENOG4107ZVW dihydroneopterin aldolase D5F51_19490 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D5F51_19495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D5F51_19500 ENOG4105VCC 30S ribosomal protein S21 D5F51_19505 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D5F51_19510 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D5F51_19520 ENOG4105EHZ conserved protein UCP016719 D5F51_19530 ENOG4105D17 glycoside hydrolase, family 3 domain protein D5F51_19535 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) D5F51_19540 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D5F51_19545 ENOG4105C5Y PTS System D5F51_19550 ENOG4105CSV Glutaminase D5F51_19555 ENOG4105E5D amino acid D5F51_19560 ENOG4105CVK Glutamate decarboxylase D5F51_19575 ENOG4108YK4 Acid-resistance membrane protein D5F51_19580 ENOG4108594 Permease of the drug metabolite transporter D5F51_19585 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D5F51_19590 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D5F51_19600 ENOG4108VKG metal-dependent hydrolase D5F51_19605 ENOG4105EE0 oxidoreductase D5F51_19615 ENOG4105DU1 integral membrane protein, terc D5F51_19620 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) D5F51_19625 ENOG4105P66 Membrane D5F51_19630 ENOG4105CTX dehydratase D5F51_19635 ENOG4107QZW Altronate oxidoreductase D5F51_19640 ENOG4105D2H Uronic isomerase D5F51_19645 ENOG4105DPW Major facilitator superfamily MFS_1 D5F51_19660 ENOG4106W5V Membrane D5F51_19675 ENOG4105NE1 Conserved Protein D5F51_19680 ENOG41090KG Inner membrane protein YqjE D5F51_19685 ENOG4105YJD D5F51_19690 ENOG4108VBZ doxx family D5F51_19695 ENOG4105CHF Glutathione S-transferase D5F51_19700 ENOG4105CWB LysR family transcriptional Regulator D5F51_19705 ENOG4108CNN domain protein D5F51_19710 ENOG4105DQ4 alcohol dehydrogenase D5F51_19715 ENOG4105EMU Dehydrogenase D5F51_19725 ENOG4107SET aldo keto reductase D5F51_19730 ENOG4105EQ2 LysR family Transcriptional regulator D5F51_19760 ENOG4105E03 chitinase D5F51_19775 ENOG4105TNG K13735 adhesin invasin D5F51_19785 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D5F51_19795 ENOG41082RQ UPF0102 protein D5F51_19800 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D5F51_19805 ENOG4105W4M Transport-associated protein D5F51_19810 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D5F51_19815 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain D5F51_19825 ENOG4105BZU Histidine kinase D5F51_19835 ENOG4105N5T Radical SAM Protein D5F51_19840 ENOG4105CBC glutamate synthase D5F51_19845 ENOG4105BZ8 glutamate synthase D5F51_19855 ENOG4105KB2 stringent starvation protein b D5F51_19860 ENOG4107MKT Stringent starvation protein a D5F51_19865 ENOG4108UJD 30S ribosomal protein S9 D5F51_19870 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D5F51_19875 ENOG4105D6Z AFG1 family ATPase D5F51_19880 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III D5F51_19885 ENOG4105C0H protease D5F51_19890 ENOG4105C0H protease D5F51_19895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D5F51_19900 ENOG4105VFK BolA family D5F51_19905 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane D5F51_19910 ENOG4105E3I toluene tolerance D5F51_19915 ENOG4107PE3 Mammalian cell entry related domain protein D5F51_19920 ENOG4105CY3 ABC transporter, permease D5F51_19925 ENOG4105DHJ ABC, transporter D5F51_19930 ENOG4105FEU K -dependent Na -Ca exchanger D5F51_19935 ENOG4105C2X Arabinose 5-phosphate isomerase D5F51_19940 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase D5F51_19945 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) D5F51_19950 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA D5F51_19955 ENOG4108IUZ ABC transporter D5F51_19960 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D5F51_19965 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA D5F51_19970 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D5F51_19975 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D5F51_19980 ENOG41080Z8 PHOSPHOCARRIER protein D5F51_19985 ENOG4105CXT aspartate transcarbamylase D5F51_19990 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) D5F51_19995 ENOG4105KME endoribonuclease L-psp D5F51_20020 ENOG4105CG3 alpha amylase, catalytic region D5F51_20025 ENOG4105C5Y PTS System D5F51_20030 ENOG4105D4X repressor D5F51_20035 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D5F51_20040 ENOG4105EMD TRANSCRIPTIONal D5F51_20045 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D5F51_20060 ENOG41069H0 dihydroorotase EC 3.5.2.3 D5F51_20090 ENOG4105NXH GreA GreB family elongation factor D5F51_20095 ENOG4108XVM Cytochrome b(562) D5F51_20100 ENOG4105CMS peptidase U62, modulator of DNA gyrase D5F51_20105 ENOG4105N42 UPF0307 protein D5F51_20110 ENOG4105UNR (Barnase) inhibitor D5F51_20125 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) D5F51_20130 ENOG4105Y49 secretion protein, HlyD family D5F51_20135 ENOG4105ZQC membrane protein AaeX D5F51_20140 ENOG4105CR8 Transcriptional regulator D5F51_20145 ENOG4105D1U peptidase U62 modulator of DNA gyrase D5F51_20155 ENOG4105QD6 exported protein D5F51_20160 ENOG4105C03 ribonuclease D5F51_20170 ENOG4105VQ7 Rod shape-determining protein MreD D5F51_20175 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D5F51_20180 ENOG4105DFF Rod shape-determining protein mreb D5F51_20185 ENOG41062P1 Diguanylate cyclase phosphodiesterase D5F51_20190 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D5F51_20200 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) D5F51_20205 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D5F51_20210 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D5F51_20215 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D5F51_20220 ENOG4105RG0 Membrane D5F51_20225 ENOG4108IA2 Sodium pantothenate symporter D5F51_20230 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D5F51_20235 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D5F51_20240 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) D5F51_20245 ENOG4105BZU Histidine kinase D5F51_20250 ENOG4108XTF Outer Membrane Lipoprotein D5F51_20255 ENOG4105VEQ Cold shock protein D5F51_20260 ENOG4105VEQ Cold shock protein D5F51_20270 ENOG4107QPK )-transporter D5F51_20275 ENOG4105D1S lipid A biosynthesis D5F51_20290 ENOG4105EZ7 amino acid ABC transporter D5F51_20295 ENOG4105DRP amino acid AbC transporter D5F51_20300 ENOG4105CDA abc transporter atp-binding protein D5F51_20315 ENOG4105CMU LysR family (Transcriptional regulator D5F51_20320 ENOG4105EEQ Na H antiporter D5F51_20325 ENOG4105C7N Xanthine uracil vitamin C permease D5F51_20335 ENOG4108UUM single-stranded DNA-binding protein D5F51_20340 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D5F51_20345 ENOG4105MSB protein, conserved in bacteria D5F51_20350 ENOG4105CGF Aromatic amino acid aminotransferase D5F51_20355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D5F51_20360 ENOG4105CDU Replicative dna helicase D5F51_20365 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D5F51_20375 ENOG4105P4Z Phage shock protein G D5F51_20380 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D5F51_20395 ENOG4105MYN Zinc uptake regulation protein D5F51_20400 ENOG4105VDW Csbd family D5F51_20405 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D5F51_20410 ENOG41080IJ Diacylglycerol kinase D5F51_20415 ENOG4105E55 glycerol-3-phosphate acyltransferase D5F51_20420 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) D5F51_20425 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) D5F51_20435 ENOG4107W52 maltose operon periplasmic protein D5F51_20440 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D5F51_20455 ENOG4107FKK extracellular solute-binding protein family 1 D5F51_20460 ENOG4105D56 permease protein D5F51_20465 ENOG4105EG2 ABC transporter, permease D5F51_20480 ENOG4105CFH Aspartokinase D5F51_20495 ENOG4105C3R Methionine synthase D5F51_20500 ENOG41069M3 Transcriptional regulator D5F51_20505 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) D5F51_20510 ENOG4108I9X Isocitrate lyase D5F51_20515 ENOG4107QP3 malate synthase g D5F51_20520 ENOG4105CVG Homoserine O-transsuccinylase D5F51_20565 ENOG4108Z0R Transferase D5F51_20570 ENOG4105E2X shikimate dehydrogenase D5F51_20575 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D5F51_20580 ENOG4108WI1 Dna topoisomerase D5F51_20590 ENOG4105C79 DNA protecting protein DprA D5F51_20595 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D5F51_20600 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D5F51_20605 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D5F51_20610 ENOG4105C1A potassium transporter peripheral membrane D5F51_20615 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D5F51_20620 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system D5F51_20625 ENOG4105W1Y Transcriptional regulator D5F51_20630 ENOG4105VTS DnaJ-like, subfamily C D5F51_20635 ENOG4108ZT0 50S ribosomal protein l17 D5F51_20640 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D5F51_20645 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D5F51_20650 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D5F51_20655 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D5F51_20660 ENOG41067V7 50S ribosomal protein L36 D5F51_20665 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D5F51_20670 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D5F51_20675 ENOG4105VPB 50S ribosomal protein L30 D5F51_20680 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D5F51_20690 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D5F51_20700 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D5F51_20705 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D5F51_20720 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D5F51_20725 ENOG41083MP 50s ribosomal protein l29 D5F51_20730 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D5F51_20735 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D5F51_20745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D5F51_20755 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D5F51_20760 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D5F51_20765 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D5F51_20800 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D5F51_20810 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D5F51_20815 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D5F51_20825 ENOG4105WWK YheO domain protein D5F51_20830 ENOG4108V1T peptidylprolyl cis-trans isomerase D5F51_20840 ENOG4108YZY peptidylprolyl cis-trans isomerase D5F51_20845 ENOG4105VKU nucleicacid-binding protein D5F51_20855 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D5F51_20860 ENOG4105C5H ABC transporter D5F51_20870 ENOG4105E2B Taurine dioxygenase D5F51_20875 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D5F51_20885 ENOG4106FTQ Taurine ABC transporter, periplasmic D5F51_20890 ENOG4105JAB phenazine biosynthesis protein, phzf family D5F51_20900 ENOG4105DNZ Alpha Beta Hydrolase D5F51_20905 ENOG4105YP7 UPF0270 protein D5F51_20910 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) D5F51_20915 ENOG4108UKZ OsmC family D5F51_20925 ENOG410613R integral membrane protein, YccS YhfK family D5F51_20930 ENOG4105C8Y Acetylornithine aminotransferase D5F51_20940 ENOG4105D7A ATP-binding protein D5F51_20945 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D5F51_20950 ENOG4105F8D glycoside hydrolase family 4 D5F51_20955 ENOG41060NJ transcriptional regulator D5F51_20970 ENOG4106DTQ Protein TsgA homolog D5F51_20975 ENOG4105DZC cytosine deaminase D5F51_20980 ENOG4107QZF nitrite reductase NADPH large subunit D5F51_20985 ENOG4105WZK nitrite reductase NADPH small subunit D5F51_20990 ENOG4107V9H nitrite transporter D5F51_20995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D5F51_21000 ENOG4105C31 Tryptophanyl-tRNA synthetase D5F51_21010 ENOG4105DJV ribulose-phosphate 3-epimerase D5F51_21030 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D5F51_21035 ENOG4105E4G Type IV pilus D5F51_21060 ENOG4108JQC penicillin-binding protein 1A D5F51_21065 ENOG4107RK2 ADP-ribose diphosphatase NudE D5F51_21070 ENOG4105DQY intracellular growth attenuator D5F51_21075 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 D5F51_21080 ENOG4105VEJ Heat shock protein D5F51_21090 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D5F51_21095 ENOG4105E0F Histidine kinase D5F51_21100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D5F51_21105 ENOG4108RRZ Transcription elongation factor GreB D5F51_21110 ENOG4105BZM domain protein D5F51_21125 ENOG4105XFK Ferrous iron transport protein A D5F51_21130 ENOG4105CE1 Ferrous iron transport protein b D5F51_21135 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) D5F51_21140 ENOG4105RID UPF0379 protein yhcN D5F51_21145 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D5F51_21150 ENOG4105MJ2 Competence protein D5F51_21155 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) D5F51_21160 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D5F51_21165 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D5F51_21170 ENOG41061ZR Transcriptional regulator D5F51_21185 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) D5F51_21190 ENOG4105E98 transcriptional regulator DeoR family D5F51_21195 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D5F51_21200 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D5F51_21205 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D5F51_21215 ENOG4108IUM Glycogen debranching enzyme D5F51_21220 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D5F51_21225 ENOG4108HRK Histidine kinase D5F51_21230 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D5F51_21235 ENOG41076UM multiple antibiotic resistance (MarC)-related protein D5F51_21240 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D5F51_21245 ENOG4105C6Z Gluconate D5F51_21250 ENOG4105DIQ Transcriptional regulator D5F51_21255 ENOG4105C2I pirin domain protein D5F51_21265 ENOG4105WCN acetyltransferase D5F51_21270 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) D5F51_21275 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D5F51_21285 ENOG4105D7K pfkb domain protein D5F51_21295 ENOG4105DH8 myo-inositol catabolism D5F51_21300 ENOG4105C26 Dehydrogenase D5F51_21315 ENOG4108HCJ Hydrolase D5F51_21320 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D5F51_21325 ENOG4107GFK fumarate D5F51_21330 ENOG41090KR LysR family transcriptional Regulator D5F51_21335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D5F51_21340 ENOG4105JZC GHMP kinase D5F51_21345 ENOG4107WFU Glutamate mutase subunit sigma D5F51_21355 ENOG4105DJI Methylaspartate mutase, E subunit D5F51_21375 ENOG4105CK2 sodium dicarboxylate symporter D5F51_21380 ENOG4105EKQ RNA-directed DNA polymerase D5F51_21440 ENOG4105CBX hi0933 family D5F51_21445 ENOG4105CJ3 phosphate transporter D5F51_21450 ENOG4108V6B universal stress protein B D5F51_21455 ENOG4108M6U Universal stress protein A D5F51_21470 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) D5F51_21475 ENOG4105DGW oligopeptidase A D5F51_21485 ENOG4105D6S protein involved in catabolism of external DNA D5F51_21490 ENOG4105DC8 reductase D5F51_21500 ENOG4107H3J ribonuclease D5F51_21505 ENOG4105CSH Transporter D5F51_21510 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) D5F51_21515 ENOG41066T0 asmA family D5F51_21520 ENOG4105CMB EAL domain-containing protein D5F51_21525 ENOG4105VSH 4-oxalocrotonate tautomerase D5F51_21530 ENOG4107SS6 2-dehydro-3-deoxygluconokinase D5F51_21535 ENOG4105CS0 peptidase D5F51_21540 ENOG4105CK2 sodium dicarboxylate symporter D5F51_21555 ENOG4108PU9 oligogalacturonate-specific porin D5F51_21560 ENOG4105BZU Histidine kinase D5F51_21570 ENOG4105EJG cellulose synthase D5F51_21575 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) D5F51_21580 ENOG4107EEX Cellulose synthase regulator protein D5F51_21585 ENOG4107QZ7 Cellulose synthase catalytic subunit D5F51_21590 ENOG4105UTS cellulose synthase operon protein YhjQ D5F51_21600 ENOG4105U74 cellulose biosynthesis protein BcsE D5F51_21605 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT D5F51_21610 ENOG4105D1V cellulose synthase operon protein YhjU D5F51_21620 ENOG4108JQ7 (ABC) transporter D5F51_21625 ENOG4105C3U ABC transporter D5F51_21630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D5F51_21635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D5F51_21640 ENOG4105DEF Extracellular solute-binding protein, family 5 D5F51_21645 ENOG4105CKT filamentous hemagglutinin D5F51_21650 ENOG4105D5K Hemolysin activator protein D5F51_21665 ENOG4105CXY transporter D5F51_21670 ENOG4105BZU Histidine kinase D5F51_21675 ENOG4108KX4 response regulator D5F51_21680 ENOG4105DIJ Phosphoethanolamine transferase D5F51_21685 ENOG4108ZHJ Organic hydroperoxide resistance protein D5F51_21695 ENOG4105C85 amino acid D5F51_21700 ENOG4105C84 Histidine ammonia-lyase D5F51_21705 ENOG4105CGP Urocanate hydratase D5F51_21710 ENOG4105ETE Transcriptional regulator (LacI family D5F51_21780 ENOG4105ZTC transcriptional activator, Ogr delta D5F51_21795 ENOG4105DFP Integrase D5F51_21805 ENOG4105T16 Transcriptional regulator (AraC family) D5F51_21810 ENOG4107RNG ABC transporter D5F51_21820 ENOG4105DFW ABC transporter D5F51_21825 ENOG4105C93 Xylose Isomerase D5F51_21830 ENOG4105CMG Carbohydrate kinase D5F51_21835 ENOG4108TTM chaperone D5F51_21840 ENOG4108RWI nicotinamidase D5F51_21850 ENOG4105MEV Acyl-transferase D5F51_21860 ENOG4105EM7 Selenocysteine-specific translation elongation factor D5F51_21865 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) D5F51_21870 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) D5F51_21875 ENOG4108MG3 formate dehydrogenase D5F51_21880 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D5F51_21890 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D5F51_21895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D5F51_21900 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_21905 ENOG4108RPX mosc domain containing protein D5F51_21910 ENOG4108YYI Protein of unknown function (DUF2810) D5F51_21915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D5F51_21925 ENOG4105E61 Mannitol repressor protein D5F51_21930 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase D5F51_21935 ENOG4105CTS PTS system mannitol-specific D5F51_21940 ENOG4106JH6 (LipO)protein D5F51_21945 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D5F51_21950 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D5F51_21955 ENOG4108R3E Dna-3-methyladenine glycosylase i D5F51_21960 ENOG4105HNP -acetyltransferase D5F51_21985 ENOG4107T9C Alpha amylase catalytic region D5F51_21990 ENOG4105JKW Valine--pyruvate aminotransferase D5F51_22015 ENOG4105R2A (LipO)protein D5F51_22020 ENOG4105D99 atp gtp-binding protein D5F51_22025 ENOG4108SGR YheO domain-containing protein D5F51_22030 ENOG4105C7B Threonine dehydratase D5F51_22050 ENOG4108TTM chaperone D5F51_22065 ENOG410667J hydrolase D5F51_22070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D5F51_22080 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D5F51_22085 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D5F51_22095 ENOG4105VG0 50S ribosomal protein l34 D5F51_22100 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D5F51_22105 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D5F51_22110 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D5F51_22115 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D5F51_22120 ENOG4105RKW reductase (By D5F51_22135 ENOG4108UMI ABC transporter, permease D5F51_22140 ENOG4105C8Q Methyl-accepting chemotaxis D5F51_22145 ENOG4108YYH Nadph-dependent fmn reductase D5F51_22150 ENOG4105BZU Histidine kinase D5F51_22165 ENOG4105C7N Xanthine uracil vitamin C permease D5F51_22170 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 D5F51_22180 ENOG4105EAD ABC transporter D5F51_22185 ENOG4106PMH Extracellular solute-binding protein family 3 D5F51_22210 ENOG4105E2Z phosphate ABC transporter (Permease D5F51_22215 ENOG4105C8U phosphate abc transporter D5F51_22220 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) D5F51_22235 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D5F51_22240 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D5F51_22245 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D5F51_22250 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D5F51_22255 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D5F51_22260 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D5F51_22265 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D5F51_22270 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D5F51_22275 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D5F51_22280 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) D5F51_22285 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation D5F51_22290 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D5F51_22295 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D5F51_22305 ENOG4108C33 Resolvase D5F51_22315 ENOG4105TNG K13735 adhesin invasin D5F51_22415 ENOG4105KT5 UmuD protein D5F51_22420 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D5F51_22500 ENOG4108S1B Periplasmic chaperone protein D5F51_22505 ENOG4108D1K outer membrane usher protein D5F51_22515 ENOG4105VUF Transcriptional regulator