locus-tag	class	description
D5F51_00005	COG0716	FMN binding
D5F51_00010	COG1522	sequence-specific DNA binding
D5F51_00015	COG2502	aspartate--ammonia ligase
D5F51_00030	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D5F51_00035	COG0714	Associated with various cellular activities
D5F51_00040	COG3158	transport of potassium into the cell
D5F51_00045	COG1869	D-ribose catabolic process
D5F51_00050	COG1129	ABC transporter
D5F51_00055	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_00060	COG1879	ABC-type sugar transport system periplasmic component
D5F51_00065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_00070	COG1609	Transcriptional regulator
D5F51_00075	COG0477	Major facilitator Superfamily
D5F51_00080	COG2186	Transcriptional regulator
D5F51_00110	COG1763	Mo-molybdopterin cofactor biosynthetic process
D5F51_00120	COG3084	Protein conserved in bacteria
D5F51_00125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5F51_00130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5F51_00135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5F51_00135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5F51_00140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5F51_00145	COG3078	GTPase activator activity
D5F51_00155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5F51_00165	COG3852	Histidine kinase
D5F51_00170	COG0174	glutamine synthetase
D5F51_00180	COG1011	Hydrolase
D5F51_00185	COG1295	ribonuclease BN
D5F51_00190	COG1490	D-aminoacyl-tRNA deacylase activity
D5F51_00195	COG0456	acetyltransferase
D5F51_00200	COG3423	Transcriptional regulator
D5F51_00215	COG2982	Protein involved in outer membrane biogenesis
D5F51_00220	COG2233	PERMEase
D5F51_00230	COG0786	glutamate:sodium symporter activity
D5F51_00235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5F51_00240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5F51_00245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5F51_00250	COG1758	RNA polymerase activity
D5F51_00260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5F51_00265	COG2860	membrane
D5F51_00275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_00280	COG1024	Enoyl-CoA hydratase
D5F51_00285	COG5001	Diguanylate cyclase
D5F51_00290	COG1561	YicC-like family, N-terminal region
D5F51_00300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D5F51_00305	COG1309	transcriptional regulator
D5F51_00310	COG0756	dUTP diphosphatase activity
D5F51_00315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5F51_00330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5F51_00335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5F51_00340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5F51_00345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5F51_00355	COG1519	Transferase
D5F51_00360	COG0859	PFAM glycosyl transferase family 9
D5F51_00365	COG0859	PFAM glycosyl transferase family 9
D5F51_00370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_00375	COG0156	8-amino-7-oxononanoate synthase activity
D5F51_00385	COG2861	carbohydrate metabolic process
D5F51_00390	COG4942	peptidase
D5F51_00395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5F51_00400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5F51_00405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_00410	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D5F51_00415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5F51_00420	COG1045	serine acetyltransferase
D5F51_00425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5F51_00430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5F51_00430	COG2169	Transcriptional regulator
D5F51_00435	COG2205	protein histidine kinase activity
D5F51_00440	COG0745	RESPONSE REGULATOR receiver
D5F51_00445	COG3678	ATP-independent chaperone mediated protein folding
D5F51_00450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5F51_00465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D5F51_00475	COG0149	triose-phosphate isomerase activity
D5F51_00485	COG3152	Membrane
D5F51_00495	COG2814	Major facilitator Superfamily
D5F51_00500	COG1494	fructose-1,6-bisphosphatase
D5F51_00510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5F51_00525	COG3074	FtsZ-dependent cytokinesis
D5F51_00530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5F51_00535	COG1575	Belongs to the MenA family. Type 1 subfamily
D5F51_00540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5F51_00550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5F51_00555	COG1609	Transcriptional regulator
D5F51_00565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5F51_00575	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D5F51_00580	COG0626	cystathionine gamma-synthase activity
D5F51_00585	COG0527	aspartate kinase activity
D5F51_00585	COG0460	homoserine dehydrogenase
D5F51_00600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D5F51_00610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5F51_00620	COG0165	Argininosuccinate lyase
D5F51_00665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_00670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_00670	COG0678	peroxiredoxin activity
D5F51_00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_00685	COG1309	transcriptional regulator
D5F51_00695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5F51_00705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5F51_00750	COG1879	ABC-type sugar transport system periplasmic component
D5F51_00755	COG1129	ABC transporter
D5F51_00760	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_00765	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_00770	COG0583	DNA-binding transcription factor activity
D5F51_00775	COG3085	chromosome segregation
D5F51_00795	COG3978	acetolactate synthase activity
D5F51_00800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5F51_00805	COG0129	dihydroxy-acid dehydratase activity
D5F51_00810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5F51_00815	COG0583	DNA-binding transcription factor activity
D5F51_00820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5F51_00840	COG3121	Chaperone
D5F51_00855	COG3121	Chaperone
D5F51_00865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5F51_00880	COG0248	Ppx GppA phosphatase
D5F51_00890	COG3118	belongs to the thioredoxin family
D5F51_00895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5F51_00900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5F51_00905	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D5F51_00910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D5F51_00915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D5F51_00920	COG1088	dTDP-glucose 4,6-dehydratase activity
D5F51_00925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D5F51_00930	COG0456	acetyltransferase
D5F51_00935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5F51_00940	COG2244	polysaccharide biosynthetic process
D5F51_00945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5F51_00965	COG1113	amino acid transport
D5F51_00990	COG3071	HemY protein
D5F51_00995	COG2959	enzyme of heme biosynthesis
D5F51_01000	COG1587	Uroporphyrinogen-III synthase
D5F51_01005	COG0181	hydroxymethylbilane synthase activity
D5F51_01015	COG3072	Adenylate cyclase
D5F51_01020	COG1965	Belongs to the frataxin family
D5F51_01025	COG5567	small periplasmic lipoprotein
D5F51_01030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5F51_01035	COG3159	Protein conserved in bacteria
D5F51_01040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5F51_01045	COG1011	Hydrolase
D5F51_01050	COG0210	DNA helicase
D5F51_01065	COG5441	Belongs to the UPF0261 family
D5F51_01070	COG5564	TIM-barrel signal transduction protein
D5F51_01080	COG0598	Magnesium transport protein CorA
D5F51_01090	COG2050	protein possibly involved in aromatic compounds catabolism
D5F51_01095	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D5F51_01100	COG0514	ATP-dependent DNA helicase (RecQ)
D5F51_01105	COG1280	lysine exporter protein (LysE YggA)
D5F51_01110	COG1280	lysine exporter protein (LysE YggA)
D5F51_01115	COG2267	carboxylic ester hydrolase activity
D5F51_01120	COG0561	phosphatase activity
D5F51_01125	COG0584	glycerophosphoryl diester phosphodiesterase
D5F51_01130	COG2271	Major facilitator Superfamily
D5F51_01135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5F51_01145	COG0247	lactate metabolic process
D5F51_01155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D5F51_01160	COG0425	Belongs to the sulfur carrier protein TusA family
D5F51_01170	COG3714	YhhN family
D5F51_01185	COG3776	membrane
D5F51_01190	COG0742	ribosomal rna small subunit methyltransferase
D5F51_01195	COG0552	protein localization to endoplasmic reticulum
D5F51_01200	COG2884	Cell division ATP-binding protein ftsE
D5F51_01205	COG2177	Part of the ABC transporter FtsEX involved in
D5F51_01215	COG0456	acetyltransferase
D5F51_01220	COG0683	leucine binding
D5F51_01225	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5F51_01230	COG4177	L-phenylalanine transmembrane transporter activity
D5F51_01235	COG0411	ABC transporter
D5F51_01240	COG0410	ABC transporter
D5F51_01290	COG1653	transport
D5F51_01295	COG1175	transmembrane transport
D5F51_01300	COG0395	ABC-type sugar transport system, permease component
D5F51_01305	COG3842	ATPase activity
D5F51_01310	COG0584	glycerophosphoryl diester phosphodiesterase
D5F51_01315	COG0679	Auxin Efflux Carrier
D5F51_01325	COG0583	DNA-binding transcription factor activity
D5F51_01330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5F51_01335	COG0412	Dienelactone hydrolase
D5F51_01340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D5F51_01350	COG1966	Carbon starvation protein
D5F51_01355	COG0586	Pfam SNARE associated Golgi protein
D5F51_01360	COG1322	Protein conserved in bacteria
D5F51_01365	COG2226	methyltransferase
D5F51_01375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5F51_01380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5F51_01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5F51_01390	COG0805	protein transport
D5F51_01410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D5F51_01420	COG0183	Belongs to the thiolase family
D5F51_01425	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5F51_01425	COG1024	Enoyl-CoA hydratase
D5F51_01435	COG1739	Uncharacterized protein family UPF0029
D5F51_01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5F51_01485	COG1072	(Pantothenic acid kinase))
D5F51_01520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5F51_01525	COG0250	Participates in transcription elongation, termination and antitermination
D5F51_01530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5F51_01545	COG0222	ribosome binding
D5F51_01550	COG0085	RNA polymerase activity
D5F51_01555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5F51_01565	COG2022	thiamine diphosphate biosynthetic process
D5F51_01570	COG2104	thiamine diphosphate biosynthetic process
D5F51_01575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5F51_01585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D5F51_01590	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D5F51_01595	COG2816	NAD+ diphosphatase activity
D5F51_01600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5F51_01605	COG1515	deoxyribonuclease V activity
D5F51_01610	COG3068	Protein conserved in bacteria
D5F51_01625	COG0151	Belongs to the GarS family
D5F51_01630	COG0138	bifunctional purine biosynthesis protein purh
D5F51_01670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5F51_01675	COG3162	membrane
D5F51_01680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5F51_01685	COG1301	dicarboxylic acid transport
D5F51_01850	COG2391	methyltransferase activity
D5F51_01855	COG0425	Belongs to the sulfur carrier protein TusA family
D5F51_01860	COG3264	Mechanosensitive ion channel
D5F51_01860	COG1196	nuclear chromosome segregation
D5F51_01865	COG4774	siderophore transport
D5F51_01885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_01890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D5F51_01895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_01900	COG4558	Periplasmic binding protein
D5F51_01905	COG3720	iron ion transport
D5F51_01925	COG3721	Heme iron utilization protein
D5F51_01955	COG1309	transcriptional regulator
D5F51_01960	COG3836	Belongs to the HpcH HpaI aldolase family
D5F51_01965	COG2084	Dehydrogenase
D5F51_01970	COG1929	Belongs to the glycerate kinase type-1 family
D5F51_01975	COG3835	regulator
D5F51_01980	COG0493	'glutamate synthase
D5F51_01980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_01985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_01990	COG3383	formate dehydrogenase (NAD+) activity
D5F51_01995	COG4232	protein-disulfide reductase activity
D5F51_02005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D5F51_02020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5F51_02025	COG0459	protein refolding
D5F51_02045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5F51_02050	COG2076	Multidrug Resistance protein
D5F51_02060	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D5F51_02065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D5F51_02070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5F51_02075	COG1053	succinate dehydrogenase
D5F51_02080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D5F51_02085	COG3264	Mechanosensitive ion channel
D5F51_02085	COG1511	domain protein
D5F51_02090	COG0688	phosphatidylethanolamine metabolic process
D5F51_02095	COG1162	GTPase activity
D5F51_02100	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D5F51_02125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D5F51_02130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D5F51_02130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D5F51_02135	COG0802	atpase or kinase
D5F51_02140	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5F51_02145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5F51_02150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5F51_02155	COG1923	regulation of RNA biosynthetic process
D5F51_02160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5F51_02165	COG0330	HflC and HflK could
D5F51_02170	COG0330	HflC and HflK could
D5F51_02180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D5F51_02185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5F51_02190	COG1959	2 iron, 2 sulfur cluster binding
D5F51_02195	COG0557	exoribonuclease II activity
D5F51_02200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5F51_02205	COG1960	acyl-CoA dehydrogenase activity
D5F51_02210	COG3650	response to hydrogen peroxide
D5F51_02215	COG1073	alpha beta
D5F51_02230	COG0360	Binds together with S18 to 16S ribosomal RNA
D5F51_02235	COG2965	DNA replication, synthesis of RNA primer
D5F51_02240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D5F51_02245	COG0359	binds to the 23S rRNA
D5F51_02255	COG3061	Opacity-associated protein A
D5F51_02260	COG0545	Peptidyl-prolyl cis-trans isomerase
D5F51_02270	COG0737	Belongs to the 5'-nucleotidase family
D5F51_02275	COG1218	3'(2'),5'-bisphosphate nucleotidase
D5F51_02280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D5F51_02290	COG1253	flavin adenine dinucleotide binding
D5F51_02295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5F51_02300	COG0729	surface antigen
D5F51_02310	COG2105	PFAM AIG2 family protein
D5F51_02315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5F51_02320	COG0840	transmembrane signaling receptor activity
D5F51_02325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D5F51_02330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5F51_02340	COG1438	arginine binding
D5F51_02345	COG0039	L-malate dehydrogenase activity
D5F51_02350	COG3423	Transcriptional regulator
D5F51_02360	COG0142	geranyltranstransferase activity
D5F51_02375	COG0697	spore germination
D5F51_02380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5F51_02385	COG0642	Histidine kinase
D5F51_02390	COG0745	RESPONSE REGULATOR receiver
D5F51_02395	COG2027	D-alanyl-D-alanine carboxypeptidase
D5F51_02400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5F51_02405	COG1534	Rna-binding protein
D5F51_02410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5F51_02415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5F51_02420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5F51_02430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5F51_02450	COG0195	Participates in both transcription termination and antitermination
D5F51_02460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5F51_02465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5F51_02475	COG1185	polyribonucleotide nucleotidyltransferase activity
D5F51_02490	COG0513	Belongs to the DEAD box helicase family
D5F51_02495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5F51_02530	COG3153	acetyltransferase
D5F51_02540	COG0531	amino acid
D5F51_02545	COG1982	Orn Lys Arg decarboxylase major
D5F51_02570	COG1653	transport
D5F51_02580	COG0395	ABC-type sugar transport system, permease component
D5F51_02585	COG3842	ATPase activity
D5F51_02595	COG3787	Belongs to the UPF0306 family
D5F51_02600	COG0702	epimerase
D5F51_02605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5F51_02610	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D5F51_02615	COG3454	Phosphonate metabolism
D5F51_02620	COG4778	phosphonate C-P lyase system protein PhnL
D5F51_02625	COG4107	phosphonate C-P lyase system protein PhnK
D5F51_02630	COG3627	carbon phosphorus lyase activity
D5F51_02635	COG3626	phosphonate metabolism
D5F51_02645	COG3624	Phosphonate C-P lyase system protein PhnG
D5F51_02650	COG2188	Transcriptional regulator
D5F51_02665	COG0602	queuosine metabolic process
D5F51_02675	COG0583	DNA-binding transcription factor activity
D5F51_02680	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5F51_02685	COG4608	Belongs to the ABC transporter superfamily
D5F51_02690	COG0444	Belongs to the ABC transporter superfamily
D5F51_02700	COG0601	transmembrane transport
D5F51_02710	COG2731	YhcH YjgK YiaL family protein
D5F51_02720	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D5F51_02740	COG2927	DNA polymerase III (CHI subunit)
D5F51_02745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5F51_02750	COG0795	lipopolysaccharide-transporting ATPase activity
D5F51_02755	COG0795	lipopolysaccharide-transporting ATPase activity
D5F51_02765	COG0582	viral genome integration into host DNA
D5F51_02775	COG3328	transposase activity
D5F51_02805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5F51_02865	COG3596	GTP binding
D5F51_02875	COG2378	regulation of single-species biofilm formation
D5F51_02905	COG2003	Belongs to the UPF0758 family
D5F51_02930	COG0454	-acetyltransferase
D5F51_02955	COG3272	Protein of unknown function (DUF1722)
D5F51_02960	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D5F51_02965	COG1830	Aldolase
D5F51_02970	COG1879	ABC-type sugar transport system periplasmic component
D5F51_02975	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_02980	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_02985	COG1129	ABC transporter
D5F51_02995	COG2390	Transcriptional regulator
D5F51_03000	COG1070	Carbohydrate kinase
D5F51_03005	COG0859	PFAM glycosyl transferase family 9
D5F51_03020	COG2235	arginine
D5F51_03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_03035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_03045	COG2376	Dihydroxyacetone kinase
D5F51_03050	COG1461	Dihydroxyacetone kinase
D5F51_03055	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D5F51_03055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_03055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5F51_03065	COG2192	nodulation
D5F51_03115	COG3706	GGDEF domain
D5F51_03145	COG0667	Aldo Keto reductase
D5F51_03150	COG2813	Specifically methylates the guanine in position
D5F51_03155	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D5F51_03165	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5F51_03170	COG2823	Periplasmic or secreted lipoprotein
D5F51_03180	COG4667	esterase of the alpha-beta hydrolase superfamily
D5F51_03185	COG0084	hydrolase, TatD family'
D5F51_03190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_03200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5F51_03205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D5F51_03210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5F51_03220	COG3726	membrane protein affecting hemolysin expression
D5F51_03225	COG0560	Phosphoserine phosphatase
D5F51_03240	COG0604	alcohol dehydrogenase
D5F51_03250	COG0488	(ABC) transporter
D5F51_03255	COG0582	viral genome integration into host DNA
D5F51_03300	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D5F51_03305	COG5532	Uncharacterized conserved protein (DUF2303)
D5F51_03345	COG1802	Transcriptional regulator
D5F51_03345	COG4626	Terminase
D5F51_03365	COG1403	HNH endonuclease
D5F51_03400	COG3179	chitinase
D5F51_03530	COG2885	chlorophyll binding
D5F51_03535	COG2199	diguanylate cyclase activity
D5F51_03545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5F51_03550	COG0741	lytic transglycosylase activity
D5F51_03555	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D5F51_03560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D5F51_03565	COG0406	alpha-ribazole phosphatase activity
D5F51_03570	COG3708	Transcriptional regulator
D5F51_03570	COG2207	Transcriptional regulator
D5F51_03575	COG3045	CreA protein
D5F51_03580	COG0745	RESPONSE REGULATOR receiver
D5F51_03595	COG0083	homoserine kinase activity
D5F51_03605	COG3022	response to hydroperoxide
D5F51_03615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5F51_03620	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5F51_03635	COG1584	GPR1 FUN34 yaaH family protein
D5F51_03645	COG0484	heat shock protein binding
D5F51_03650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D5F51_03655	COG0583	DNA-binding transcription factor activity
D5F51_03675	COG0196	riboflavin kinase activity
D5F51_03680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5F51_03685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5F51_03690	COG1047	Peptidyl-prolyl cis-trans
D5F51_03695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5F51_03700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5F51_03705	COG0505	Belongs to the CarA family
D5F51_03710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5F51_03715	COG1280	lysine exporter protein (LysE YggA)
D5F51_03720	COG2966	Psort location CytoplasmicMembrane, score
D5F51_03725	COG3610	response to peptide
D5F51_03730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5F51_03735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5F51_03740	COG2967	ApaG domain
D5F51_03750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5F51_03755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5F51_03760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5F51_03765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5F51_03775	COG0564	pseudouridine synthase activity
D5F51_03780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5F51_03785	COG0417	DNA replication proofreading
D5F51_03790	COG0586	Pfam SNARE associated Golgi protein
D5F51_03800	COG1178	ABC-type Fe3 transport system permease component
D5F51_03805	COG4143	(ABC) transporter
D5F51_03810	COG4533	DNA binding
D5F51_03815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5F51_03825	COG2814	Major facilitator Superfamily
D5F51_03830	COG0814	amino acid
D5F51_03835	COG3033	Beta-eliminating lyase
D5F51_03850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5F51_03855	COG0473	3-isopropylmalate dehydrogenase activity
D5F51_03860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5F51_03880	COG1022	Amp-dependent synthetase and ligase
D5F51_03885	COG0028	Belongs to the TPP enzyme family
D5F51_03895	COG1609	Transcriptional regulator
D5F51_03910	COG0275	rRNA processing
D5F51_03915	COG3116	cell division
D5F51_03920	COG0768	penicillin binding
D5F51_03925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5F51_03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5F51_03935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5F51_03945	COG0772	Belongs to the SEDS family
D5F51_03950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5F51_03955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5F51_03965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5F51_03970	COG0849	cell division
D5F51_03975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5F51_03995	COG0653	protein targeting
D5F51_04000	COG0494	nUDIX hydrolase
D5F51_04005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5F51_04015	COG0237	dephospho-CoA kinase activity
D5F51_04025	COG0516	GMP reductase activity
D5F51_04035	COG3328	transposase activity
D5F51_04045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_04050	COG4969	Belongs to the N-Me-Phe pilin family
D5F51_04060	COG3023	N-Acetylmuramoyl-L-alanine amidase
D5F51_04065	COG3725	Membrane protein required for beta-lactamase induction
D5F51_04135	COG4386	tail sheath protein
D5F51_04160	COG4397	Mu-like prophage major head subunit gpT
D5F51_04190	COG4383	Mu-like prophage protein gp29
D5F51_04230	COG3179	chitinase
D5F51_04245	COG4382	Mu-like prophage protein Gp16
D5F51_04325	COG3423	Transcriptional regulator
D5F51_04340	COG3328	transposase activity
D5F51_04345	COG1113	amino acid transport
D5F51_04350	COG2186	Transcriptional regulator
D5F51_04360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D5F51_04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5F51_04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_04390	COG1049	propionate catabolic process, 2-methylcitrate cycle
D5F51_04395	COG3112	Uncharacterised protein family (UPF0231)
D5F51_04400	COG0697	spore germination
D5F51_04410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5F51_04420	COG2132	Multicopper oxidase
D5F51_04425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D5F51_04430	COG0288	reversible hydration of carbon dioxide
D5F51_04435	COG1131	(ABC) transporter
D5F51_04440	COG0842	Transport permease protein
D5F51_04445	COG0726	polysaccharide deacetylase
D5F51_04450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D5F51_04455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5F51_04460	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D5F51_04465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5F51_04470	COG0617	tRNA 3'-terminal CCA addition
D5F51_04475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5F51_04480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5F51_04490	COG1489	DNA binding
D5F51_04495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5F51_04500	COG1643	Atp-dependent helicase
D5F51_04505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5F51_04510	COG1120	ATPase activity
D5F51_04515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5F51_04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_04525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5F51_04535	COG0316	Belongs to the HesB IscA family
D5F51_04545	COG2860	membrane
D5F51_04555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5F51_04560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D5F51_04565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5F51_04570	COG4999	Histidine kinase
D5F51_04570	COG3850	Histidine kinase
D5F51_04570	COG2205	protein histidine kinase activity
D5F51_04570	COG3437	response regulator, receiver
D5F51_04575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5F51_04580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5F51_04585	COG3956	TIGRFAM MazG family protein
D5F51_04590	COG0504	CTP synthase activity
D5F51_04595	COG0148	phosphopyruvate hydratase activity
D5F51_04605	COG0602	queuosine metabolic process
D5F51_04610	COG0720	synthase
D5F51_04615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5F51_04620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5F51_04625	COG0175	sulfate reduction
D5F51_04630	COG2234	aminopeptidase activity
D5F51_04635	COG1648	precorrin-2 dehydrogenase activity
D5F51_04635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_04640	COG0175	sulfate reduction
D5F51_04645	COG2895	sulfate adenylyltransferase (ATP) activity
D5F51_04650	COG0529	Catalyzes the synthesis of activated sulfate
D5F51_04665	COG0765	amino acid transport
D5F51_04675	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5F51_04685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5F51_04690	COG0585	pseudouridine synthase activity
D5F51_04695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5F51_04700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5F51_04705	COG1388	LysM domain
D5F51_04705	COG4942	peptidase
D5F51_04710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5F51_04715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5F51_04730	COG0288	reversible hydration of carbon dioxide
D5F51_04735	COG0786	glutamate:sodium symporter activity
D5F51_04760	COG3210	domain, Protein
D5F51_04795	COG2831	hemolysin activation secretion protein
D5F51_04805	COG2365	Tyrosine phosphatase family
D5F51_04810	COG3328	transposase activity
D5F51_04815	COG0582	viral genome integration into host DNA
D5F51_04835	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5F51_04840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5F51_04845	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5F51_04850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5F51_04855	COG1138	Cytochrome C-type biogenesis protein
D5F51_04860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5F51_04870	COG4235	cytochrome complex assembly
D5F51_04870	COG3088	subunit of a heme lyase
D5F51_04885	COG3691	Protein conserved in bacteria
D5F51_04890	COG0183	Belongs to the thiolase family
D5F51_04895	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5F51_04895	COG1024	Enoyl-CoA hydratase
D5F51_04900	COG2062	phosphohistidine phosphatase, SixA
D5F51_04905	COG2840	Smr protein MutS2
D5F51_04910	COG2890	protein-(glutamine-N5) methyltransferase activity
D5F51_04915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5F51_04920	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D5F51_04925	COG0730	response to heat
D5F51_04930	COG3101	peptidyl-lysine hydroxylation
D5F51_04940	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D5F51_04940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5F51_04945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5F51_04955	COG1794	racemase activity, acting on amino acids and derivatives
D5F51_04965	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5F51_04970	COG2723	6-phospho-beta-galactosidase activity
D5F51_04975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5F51_04995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5F51_05020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5F51_05025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_05035	COG0697	spore germination
D5F51_05045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5F51_05050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5F51_05060	COG0586	Pfam SNARE associated Golgi protein
D5F51_05065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5F51_05070	COG0285	dihydrofolate synthase activity
D5F51_05075	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D5F51_05080	COG1286	toxin biosynthetic process
D5F51_05085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5F51_05090	COG0163	prenyltransferase activity
D5F51_05100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_05105	COG4215	(ABC) transporter
D5F51_05110	COG4160	amino acid transport
D5F51_05115	COG4598	ABC transporter
D5F51_05120	COG1090	epimerase
D5F51_05130	COG0622	Phosphoesterase
D5F51_05135	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D5F51_05140	COG3037	sugar-specific permease SgaT UlaA
D5F51_05150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_05155	COG1609	Transcriptional regulator
D5F51_05160	COG0280	phosphate acetyltransferase
D5F51_05160	COG0857	belongs to the CobB CobQ family
D5F51_05170	COG3092	negative regulation of chromosome organization
D5F51_05175	COG3013	Belongs to the UPF0304 family
D5F51_05180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_05190	COG0471	metal ion transport
D5F51_05190	COG0490	domain, Protein
D5F51_05200	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D5F51_05205	COG0436	Aminotransferase
D5F51_05210	COG0583	DNA-binding transcription factor activity
D5F51_05215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_05220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_05225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_05225	COG0649	NAD binding
D5F51_05230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D5F51_05240	COG1034	ATP synthesis coupled electron transport
D5F51_05245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5F51_05250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_05255	COG0839	Belongs to the complex I subunit 6 family
D5F51_05260	COG0713	ATP synthesis coupled electron transport
D5F51_05265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5F51_05270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_05275	COG1007	ATP synthesis coupled electron transport
D5F51_05300	COG3265	gluconokinase activity
D5F51_05305	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_05310	COG1609	Transcriptional regulator
D5F51_05315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5F51_05325	COG4702	Belongs to the UPF0303 family
D5F51_05335	COG4575	ribosome binding
D5F51_05340	COG1169	isochorismate synthase
D5F51_05345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D5F51_05350	COG0596	Alpha beta hydrolase
D5F51_05355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D5F51_05360	COG1441	menaquinone biosynthetic process
D5F51_05380	COG0814	amino acid
D5F51_05390	COG4574	serine-type endopeptidase inhibitor activity
D5F51_05395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_05405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5F51_05410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5F51_05420	COG0784	Response regulator, receiver
D5F51_05420	COG2205	protein histidine kinase activity
D5F51_05430	COG0642	Histidine kinase
D5F51_05430	COG2198	Histidine kinase
D5F51_05435	COG2223	nitrite transmembrane transporter activity
D5F51_05445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D5F51_05460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5F51_05490	COG2190	(PTS) system
D5F51_05490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_05490	COG1263	PTS System
D5F51_05495	COG2723	6-phospho-beta-galactosidase activity
D5F51_05520	COG3082	Protein of unknown function (DUF1414)
D5F51_05525	COG3081	Nucleoid-associated protein
D5F51_05535	COG1061	Type III restriction enzyme res subunit
D5F51_05540	COG1187	pseudouridine synthase activity
D5F51_05545	COG2814	Major facilitator Superfamily
D5F51_05555	COG4172	Belongs to the ABC transporter superfamily
D5F51_05560	COG4239	(ABC) transporter, permease
D5F51_05565	COG4174	ABC transporter (Permease)
D5F51_05570	COG4166	transmembrane transport
D5F51_05575	COG2200	EAL domain
D5F51_05585	COG0791	NLP P60 protein
D5F51_05590	COG0671	phosphoesterase, PA-phosphatase related
D5F51_05595	COG0523	cobalamin synthesis protein
D5F51_05605	COG2186	Transcriptional regulator
D5F51_05610	COG0246	Mannitol dehydrogenase
D5F51_05620	COG1312	Catalyzes the dehydration of D-mannonate
D5F51_05625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5F51_05650	COG1105	Belongs to the carbohydrate kinase PfkB family
D5F51_05655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5F51_05655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D5F51_05655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5F51_05660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D5F51_05665	COG2855	membrane
D5F51_05675	COG0583	DNA-binding transcription factor activity
D5F51_05680	COG0833	amino acid
D5F51_05685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_05695	COG4771	TonB-dependent receptor
D5F51_05700	COG0625	glutathione transferase activity
D5F51_05730	COG2011	ABC-type metal ion transport system permease component
D5F51_05735	COG0626	cystathionine gamma-synthase activity
D5F51_05745	COG1686	Belongs to the peptidase S11 family
D5F51_05750	COG1760	l-serine dehydratase
D5F51_05755	COG0814	amino acid
D5F51_05760	COG1349	DNA-binding transcription factor activity
D5F51_05765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5F51_05770	COG0671	phosphoesterase, PA-phosphatase related
D5F51_05780	COG2985	domain, Protein
D5F51_05780	COG0569	domain protein
D5F51_05785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_05800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5F51_05805	COG3842	ATPase activity
D5F51_05810	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5F51_05815	COG1177	transmembrane transport
D5F51_05825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5F51_05830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_05840	COG4160	amino acid transport
D5F51_05845	COG4215	(ABC) transporter
D5F51_05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_05855	COG1126	abc transporter atp-binding protein
D5F51_05870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_05875	COG0702	epimerase
D5F51_05880	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D5F51_05885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D5F51_05890	COG0028	Belongs to the TPP enzyme family
D5F51_05895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_05900	COG1151	hydroxylamine reductase activity
D5F51_05905	COG2431	L-lysine efflux transmembrane transporter activity
D5F51_05910	COG3593	DNA synthesis involved in DNA repair
D5F51_05915	COG2990	Protein conserved in bacteria
D5F51_05920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_05930	COG1278	Cold shock
D5F51_05935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5F51_05940	COG0542	response to heat
D5F51_05945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5F51_05950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5F51_05955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D5F51_05965	COG0492	ferredoxin-NADP+ reductase activity
D5F51_05975	COG3107	peptidoglycan biosynthetic process
D5F51_05975	COG1674	ftsk spoiiie
D5F51_05980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5F51_05985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5F51_05995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5F51_06000	COG2814	Major facilitator Superfamily
D5F51_06005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5F51_06010	COG1882	Formate acetyltransferase
D5F51_06015	COG2116	formate transmembrane transporter activity
D5F51_06020	COG1944	ATP diphosphatase activity
D5F51_06025	COG0252	asparaginase activity
D5F51_06030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5F51_06035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5F51_06040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5F51_06045	COG0539	negative regulation of cytoplasmic translation
D5F51_06050	COG0776	regulation of translation
D5F51_06055	COG0658	competence protein
D5F51_06055	COG2333	competence protein COMEC
D5F51_06065	COG1663	tetraacyldisaccharide 4'-kinase activity
D5F51_06070	COG5383	Protein conserved in bacteria
D5F51_06075	COG1278	Cold shock
D5F51_06080	COG1278	Cold shock
D5F51_06085	COG2835	tetraacyldisaccharide 4'-kinase activity
D5F51_06090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5F51_06095	COG3173	Aminoglycoside phosphotransferase
D5F51_06100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D5F51_06105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5F51_06110	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D5F51_06115	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D5F51_06120	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D5F51_06125	COG2989	Protein conserved in bacteria
D5F51_06130	COG3108	Peptidase M15
D5F51_06135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5F51_06140	COG2200	EAL domain
D5F51_06145	COG1448	Aminotransferase
D5F51_06155	COG0017	Asparaginyl-tRNA synthetase
D5F51_06160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D5F51_06165	COG3866	Pectate lyase
D5F51_06170	COG0308	aminopeptidase N
D5F51_06175	COG0167	dihydroorotate dehydrogenase activity
D5F51_06185	COG3217	Mosc domain protein beta barrel domain protein
D5F51_06185	COG0633	Ferredoxin
D5F51_06190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5F51_06190	COG0116	Belongs to the methyltransferase superfamily
D5F51_06195	COG0488	(ABC) transporter
D5F51_06200	COG2995	paraquat-inducible protein a
D5F51_06205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5F51_06205	COG3008	intermembrane lipid transfer
D5F51_06210	COG3009	Protein conserved in bacteria
D5F51_06215	COG3130	regulation of translation
D5F51_06220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5F51_06230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5F51_06235	COG1067	ATP-dependent peptidase activity
D5F51_06240	COG3120	sequence-specific DNA binding
D5F51_06245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D5F51_06245	COG2885	chlorophyll binding
D5F51_06250	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
D5F51_06255	COG3070	regulator of competence-specific genes
D5F51_06260	COG1289	transmembrane transporter activity
D5F51_06265	COG3304	Inner membrane component domain
D5F51_06270	COG0210	DNA helicase
D5F51_06275	COG1803	Methylglyoxal synthase
D5F51_06280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D5F51_06285	COG1832	CoA-binding protein
D5F51_06290	COG3785	DNA binding
D5F51_06295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5F51_06310	COG1254	Belongs to the acylphosphatase family
D5F51_06315	COG2920	part of a sulfur-relay system
D5F51_06325	COG2771	luxR family
D5F51_06330	COG3916	Acyl-homoserine-lactone synthase
D5F51_06340	COG3263	regulation of cellular component size
D5F51_06355	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D5F51_06360	COG2943	transferase activity, transferring hexosyl groups
D5F51_06365	COG5645	(Lipo)protein
D5F51_06375	COG3104	oligopeptide transport
D5F51_06380	COG2814	Major facilitator Superfamily
D5F51_06385	COG2259	Doxx family
D5F51_06390	COG1560	Kdo2-lipid A biosynthetic process
D5F51_06415	COG0628	permease
D5F51_06445	COG0418	dihydroorotase activity
D5F51_06450	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D5F51_06455	COG1530	ribonuclease E activity
D5F51_06455	COG1530	ribonuclease E activity
D5F51_06465	COG0564	pseudouridine synthase activity
D5F51_06475	COG1399	metal-binding, possibly nucleic acid-binding protein
D5F51_06480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5F51_06485	COG0416	fatty acid biosynthetic process
D5F51_06495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5F51_06500	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_06510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5F51_06515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5F51_06520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5F51_06525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5F51_06530	COG0470	DNA polymerase III
D5F51_06535	COG0084	hydrolase, TatD family'
D5F51_06540	COG1263	PTS System
D5F51_06540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_06550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5F51_06555	COG0537	adenosine 5'-monophosphoramidase activity
D5F51_06560	COG5633	Lipoprotein
D5F51_06565	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D5F51_06570	COG0510	thiamine kinase activity
D5F51_06575	COG1472	Belongs to the glycosyl hydrolase 3 family
D5F51_06580	COG3150	esterase
D5F51_06585	COG1252	NADH dehydrogenase
D5F51_06590	COG3134	Outer membrane lipoprotein
D5F51_06595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5F51_06600	COG4591	ABC-type transport system involved in lipoprotein release permease component
D5F51_06610	COG4591	ABC-type transport system involved in lipoprotein release permease component
D5F51_06615	COG1940	carbohydrate kinase activity
D5F51_06620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5F51_06630	COG2850	peptidyl-arginine hydroxylation
D5F51_06640	COG0745	RESPONSE REGULATOR receiver
D5F51_06650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5F51_06655	COG2915	High frequency lysogenization protein hflD homolog
D5F51_06660	COG0482	sulfurtransferase activity
D5F51_06670	COG1187	pseudouridine synthase activity
D5F51_06675	COG0538	isocitrate dehydrogenase activity
D5F51_06710	COG0840	transmembrane signaling receptor activity
D5F51_06720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5F51_06730	COG2873	o-acetylhomoserine
D5F51_06735	COG0702	epimerase
D5F51_06740	COG1733	regulation of RNA biosynthetic process
D5F51_06755	COG2721	sulfolactate sulfo-lyase activity
D5F51_06760	COG0246	Mannitol dehydrogenase
D5F51_06765	COG1063	alcohol dehydrogenase
D5F51_06770	COG1802	Transcriptional regulator
D5F51_06775	COG4948	Mandelate Racemase Muconate Lactonizing
D5F51_06780	COG2271	Major facilitator Superfamily
D5F51_06795	COG3755	Protein conserved in bacteria
D5F51_06810	COG5001	Diguanylate cyclase
D5F51_06810	COG3706	GGDEF domain
D5F51_06810	COG4251	negative regulation of phosphorylation
D5F51_06810	COG2203	Gaf domain
D5F51_06820	COG1132	(ABC) transporter
D5F51_06840	COG2207	Transcriptional regulator
D5F51_06875	COG1113	amino acid transport
D5F51_06890	COG1278	Cold shock
D5F51_06900	COG0768	penicillin binding
D5F51_06905	COG2226	methyltransferase
D5F51_06915	COG5002	protein histidine kinase activity
D5F51_06915	COG5001	Diguanylate cyclase
D5F51_06915	COG3447	MASE1 domain protein
D5F51_06925	COG1971	Probably functions as a manganese efflux pump
D5F51_06930	COG4811	Protein of unknown function (DUF986)
D5F51_06935	COG3716	PTS system mannose fructose sorbose family IID component
D5F51_06940	COG3715	PTS system
D5F51_06945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_06945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_06950	COG1253	flavin adenine dinucleotide binding
D5F51_06960	COG1760	l-serine dehydratase
D5F51_06965	COG0494	nUDIX hydrolase
D5F51_06975	COG3140	Belongs to the UPF0181 family
D5F51_06980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D5F51_06985	COG0513	Belongs to the DEAD box helicase family
D5F51_06990	COG3141	response to X-ray
D5F51_07005	COG1770	oligopeptidase
D5F51_07010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5F51_07025	COG1528	Iron-storage protein
D5F51_07030	COG2372	response to copper ion
D5F51_07035	COG1276	copper resistance
D5F51_07045	COG0582	viral genome integration into host DNA
D5F51_07085	COG1396	sequence-specific DNA binding
D5F51_07160	COG3081	Nucleoid-associated protein
D5F51_07170	COG3772	lysozyme
D5F51_07190	COG1475	DNA binding
D5F51_07225	COG3567	Phage-associated protein, HI1409 family
D5F51_07235	COG3566	protein conserved in bacteria
D5F51_07350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_07350	COG2755	lipolytic protein G-D-S-L family
D5F51_07490	COG1187	pseudouridine synthase activity
D5F51_07515	COG0625	glutathione transferase activity
D5F51_07545	COG5001	Diguanylate cyclase
D5F51_07545	COG3706	GGDEF domain
D5F51_07545	COG2203	Gaf domain
D5F51_07545	COG4251	negative regulation of phosphorylation
D5F51_07590	COG3008	intermembrane lipid transfer
D5F51_07595	COG2995	paraquat-inducible protein a
D5F51_07600	COG1956	GAF domain-containing protein
D5F51_07610	COG0793	Belongs to the peptidase S41A family
D5F51_07615	COG0501	Belongs to the peptidase M48B family
D5F51_07620	COG2814	Major facilitator Superfamily
D5F51_07625	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_07635	COG3023	N-Acetylmuramoyl-L-alanine amidase
D5F51_07645	COG1988	membrane-bound metal-dependent
D5F51_07650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5F51_07660	COG3842	ATPase activity
D5F51_07665	COG0395	ABC-type sugar transport system, permease component
D5F51_07670	COG1175	transmembrane transport
D5F51_07680	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_07685	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D5F51_07690	COG1917	Cupin 2, conserved barrel domain protein
D5F51_07695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_07705	COG0583	DNA-binding transcription factor activity
D5F51_07710	COG0427	acetyl-CoA hydrolase
D5F51_07715	COG1024	Enoyl-CoA hydratase
D5F51_07720	COG1703	isobutyryl-CoA mutase activity
D5F51_07725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5F51_07725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5F51_07740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_07745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_07750	COG1121	(ABC) transporter
D5F51_07755	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5F51_07790	COG1811	Na channel or pump
D5F51_07795	COG4249	Peptidase C14 caspase catalytic subunit p20
D5F51_07800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5F51_07805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5F51_07815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5F51_07830	COG0776	regulation of translation
D5F51_07835	COG2314	TM2 domain
D5F51_07845	COG4139	cobalamin transport
D5F51_07850	COG0386	Belongs to the glutathione peroxidase family
D5F51_07855	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D5F51_07860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5F51_07865	COG0463	Glycosyl transferase, family 2
D5F51_07875	COG0726	polysaccharide deacetylase
D5F51_07880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D5F51_07885	COG2076	Multidrug Resistance protein
D5F51_07890	COG2076	Multidrug Resistance protein
D5F51_07895	COG0791	NLP P60 protein
D5F51_07900	COG0095	Lipoate-protein ligase
D5F51_07910	COG4558	Periplasmic binding protein
D5F51_07915	COG3720	iron ion transport
D5F51_07920	COG4771	TonB-dependent receptor
D5F51_07935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5F51_07940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5F51_07940	COG0574	Belongs to the PEP-utilizing enzyme family
D5F51_07950	COG0628	permease
D5F51_07955	COG0247	lactate metabolic process
D5F51_07955	COG0277	FAD linked oxidase domain protein
D5F51_07960	COG2050	protein possibly involved in aromatic compounds catabolism
D5F51_07970	COG0316	Belongs to the HesB IscA family
D5F51_07975	COG0719	Fe-S assembly protein
D5F51_07980	COG0396	ATPase activity
D5F51_07985	COG0719	Fe-S assembly protein
D5F51_07995	COG2166	iron-sulfur cluster assembly
D5F51_08000	COG1376	ErfK ybiS ycfS ynhG family protein
D5F51_08000	COG1388	LysM domain
D5F51_08005	COG4238	major outer membrane lipoprotein
D5F51_08030	COG0534	Mate efflux family protein
D5F51_08035	COG0307	riboflavin synthase, alpha
D5F51_08040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D5F51_08045	COG2814	Major facilitator Superfamily
D5F51_08050	COG0583	DNA-binding transcription factor activity
D5F51_08055	COG1609	Transcriptional regulator
D5F51_08065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5F51_08070	COG0791	NLP P60 protein
D5F51_08075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D5F51_08080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5F51_08085	COG0346	lactoylglutathione lyase activity
D5F51_08090	COG1902	pentaerythritol trinitrate reductase activity
D5F51_08095	COG1309	transcriptional regulator
D5F51_08100	COG2194	sulfuric ester hydrolase activity
D5F51_08105	COG3313	Fe-S protein
D5F51_08110	COG4989	oxidoreductase activity
D5F51_08115	COG1289	transmembrane transporter activity
D5F51_08120	COG1566	PFAM secretion protein HlyD family protein
D5F51_08130	COG1846	Transcriptional regulator
D5F51_08135	COG3133	Outer membrane lipoprotein
D5F51_08140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D5F51_08145	COG3895	Periplasmic Protein
D5F51_08150	COG0259	pyridoxamine-phosphate oxidase activity
D5F51_08155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5F51_08165	COG0625	glutathione transferase activity
D5F51_08185	COG3104	oligopeptide transport
D5F51_08195	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5F51_08195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5F51_08230	COG3121	Chaperone
D5F51_08235	COG3188	usher protein
D5F51_08240	COG4172	Belongs to the ABC transporter superfamily
D5F51_08250	COG4171	peptide transport system, permease
D5F51_08255	COG4168	peptide transport system, permease
D5F51_08270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D5F51_08275	COG1842	Phage shock protein A
D5F51_08285	COG1983	PspC domain protein
D5F51_08295	COG3106	COG3106 Predicted ATPase
D5F51_08300	COG3768	UPF0283 membrane protein
D5F51_08320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D5F51_08325	COG4948	Mandelate Racemase Muconate Lactonizing
D5F51_08330	COG2866	Carboxypeptidase
D5F51_08335	COG4166	transmembrane transport
D5F51_08355	COG0037	tRNA processing
D5F51_08360	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_08370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D5F51_08370	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5F51_08370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_08370	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5F51_08385	COG3042	response to heat
D5F51_08390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5F51_08395	COG2911	Protein conserved in bacteria
D5F51_08405	COG3784	Protein of unknown function (DUF1318)
D5F51_08415	COG1070	Carbohydrate kinase
D5F51_08420	COG0246	Mannitol dehydrogenase
D5F51_08425	COG2390	Transcriptional regulator
D5F51_08430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5F51_08435	COG1643	Atp-dependent helicase
D5F51_08440	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
D5F51_08450	COG3591	Belongs to the peptidase S1B family
D5F51_08460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D5F51_08465	COG2205	protein histidine kinase activity
D5F51_08470	COG0745	RESPONSE REGULATOR receiver
D5F51_08480	COG0531	amino acid
D5F51_08495	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D5F51_08500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D5F51_08505	COG0589	response to stress
D5F51_08510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5F51_08515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5F51_08530	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D5F51_08540	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_08555	COG0738	Major facilitator superfamily
D5F51_08570	COG0583	DNA-binding transcription factor activity
D5F51_08580	COG1011	Hydrolase
D5F51_08590	COG0440	acetolactate synthase activity
D5F51_08595	COG0028	Belongs to the TPP enzyme family
D5F51_08615	COG3121	Chaperone
D5F51_08620	COG3188	usher protein
D5F51_08630	COG2831	hemolysin activation secretion protein
D5F51_08635	COG3064	Membrane
D5F51_08635	COG3210	domain, Protein
D5F51_08635	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_08635	COG3210	domain, Protein
D5F51_08635	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_08635	COG3064	Membrane
D5F51_08640	COG3710	Transcriptional regulator
D5F51_08650	COG2197	response regulator
D5F51_08675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5F51_08705	COG4215	(ABC) transporter
D5F51_08715	COG1522	sequence-specific DNA binding
D5F51_08725	COG0625	glutathione transferase activity
D5F51_08755	COG0477	Major facilitator Superfamily
D5F51_08760	COG4221	oxidoreductase activity
D5F51_08765	COG1742	UPF0060 membrane protein
D5F51_08790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D5F51_08795	COG1940	carbohydrate kinase activity
D5F51_08800	COG0583	DNA-binding transcription factor activity
D5F51_08805	COG2814	Major facilitator Superfamily
D5F51_08825	COG2020	methyltransferase activity
D5F51_08830	COG0114	fumarate hydratase activity
D5F51_08840	COG5339	Protein conserved in bacteria
D5F51_08845	COG1609	Transcriptional regulator
D5F51_08850	COG1263	PTS System
D5F51_08850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_08855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5F51_08860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D5F51_08865	COG0385	Bile acid
D5F51_08870	COG0673	inositol 2-dehydrogenase activity
D5F51_08880	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_08890	COG1879	ABC-type sugar transport system periplasmic component
D5F51_08900	COG2160	L-arabinose isomerase activity
D5F51_08905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5F51_08910	COG2274	protein secretion by the type I secretion system
D5F51_08915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_08930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D5F51_08940	COG4657	Part of a membrane complex involved in electron transport
D5F51_08950	COG4656	Part of a membrane complex involved in electron transport
D5F51_08955	COG3708	Transcriptional regulator
D5F51_08955	COG2207	Transcriptional regulator
D5F51_08960	COG4658	electron transport chain
D5F51_08965	COG4659	FMN binding
D5F51_08975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5F51_08985	COG0243	molybdopterin cofactor binding
D5F51_08990	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D5F51_08995	COG1966	Carbon starvation protein
D5F51_09000	COG2879	small protein
D5F51_09005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5F51_09010	COG1349	DNA-binding transcription factor activity
D5F51_09020	COG0235	Class ii aldolase
D5F51_09030	COG0023	Translation Initiation Factor
D5F51_09035	COG0284	orotidine-5'-phosphate decarboxylase activity
D5F51_09045	COG3135	benzoate transporter
D5F51_09050	COG1396	sequence-specific DNA binding
D5F51_09060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D5F51_09065	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D5F51_09070	COG0671	phosphoesterase, PA-phosphatase related
D5F51_09075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5F51_09080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5F51_09095	COG0583	DNA-binding transcription factor activity
D5F51_09100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5F51_09115	COG0616	signal peptide processing
D5F51_09120	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_09125	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D5F51_09130	COG1187	pseudouridine synthase activity
D5F51_09155	COG2197	response regulator
D5F51_09165	COG0009	L-threonylcarbamoyladenylate synthase
D5F51_09170	COG0613	PHP domain protein
D5F51_09185	COG0512	Glutamine amidotransferase of anthranilate synthase
D5F51_09195	COG0134	indole-3-glycerol-phosphate synthase activity
D5F51_09195	COG0135	phosphoribosylanthranilate isomerase activity
D5F51_09200	COG0133	tryptophan synthase activity
D5F51_09205	COG0159	tryptophan synthase activity
D5F51_09215	COG3047	cAMP biosynthetic process
D5F51_09235	COG2917	probably involved in intracellular septation
D5F51_09240	COG1607	acyl-coa hydrolase
D5F51_09245	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D5F51_09250	COG2350	Protein conserved in bacteria
D5F51_09275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5F51_09285	COG4608	Belongs to the ABC transporter superfamily
D5F51_09290	COG0444	Belongs to the ABC transporter superfamily
D5F51_09295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_09315	COG2095	MarC family integral membrane protein
D5F51_09325	COG1454	alcohol dehydrogenase
D5F51_09325	COG1012	belongs to the aldehyde dehydrogenase family
D5F51_09330	COG1435	thymidine kinase activity
D5F51_09340	COG2916	Histone family protein nucleoid-structuring protein H-NS
D5F51_09350	COG0745	RESPONSE REGULATOR receiver
D5F51_09355	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5F51_09360	COG3012	SEC-C Motif Domain Protein
D5F51_09365	COG0788	formyltetrahydrofolate deformylase activity
D5F51_09395	COG0708	Exodeoxyribonuclease III
D5F51_09400	COG0494	nUDIX hydrolase
D5F51_09410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5F51_09420	COG0778	Nitroreductase
D5F51_09425	COG0616	signal peptide processing
D5F51_09430	COG0252	asparaginase activity
D5F51_09435	COG1335	isochorismatase
D5F51_09440	COG3139	Protein of unknown function (DUF1315)
D5F51_09460	COG3713	MltA-interacting MipA family protein
D5F51_09470	COG2766	serine protein kinase
D5F51_09475	COG2718	Belongs to the UPF0229 family
D5F51_09490	COG0583	DNA-binding transcription factor activity
D5F51_09500	COG2199	diguanylate cyclase activity
D5F51_09500	COG2200	EAL domain
D5F51_09500	COG2202	Pas domain
D5F51_09505	COG2814	Major facilitator Superfamily
D5F51_09510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5F51_09515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5F51_09520	COG2719	SpoVR family
D5F51_09525	COG2186	Transcriptional regulator
D5F51_09530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D5F51_09535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5F51_09545	COG2983	Belongs to the UPF0260 family
D5F51_09550	COG0179	Fumarylacetoacetate (FAA) hydrolase
D5F51_09555	COG2951	lytic endotransglycosylase activity
D5F51_09570	COG0850	regulation of cytokinetic process
D5F51_09575	COG2894	cell division
D5F51_09580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D5F51_09585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D5F51_09590	COG0318	PFAM AMP-dependent synthetase and ligase
D5F51_09595	COG3065	identical protein binding
D5F51_09605	COG1199	ATP-dependent helicase activity
D5F51_09610	COG0251	oxidation-reduction process
D5F51_09615	COG2076	Multidrug Resistance protein
D5F51_09620	COG2076	Multidrug Resistance protein
D5F51_09625	COG0800	Aldolase
D5F51_09630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5F51_09635	COG1737	Transcriptional regulator
D5F51_09640	COG0469	pyruvate kinase activity
D5F51_09645	COG1560	Kdo2-lipid A biosynthetic process
D5F51_09650	COG0739	heme binding
D5F51_09655	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D5F51_09660	COG1121	(ABC) transporter
D5F51_09665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_09670	COG3104	oligopeptide transport
D5F51_09675	COG2255	four-way junction helicase activity
D5F51_09690	COG0217	transcriptional regulatory protein
D5F51_09695	COG0494	nUDIX hydrolase
D5F51_09700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5F51_09710	COG1335	isochorismatase
D5F51_09715	COG1801	Protein of unknown function DUF72
D5F51_09720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D5F51_09730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5F51_09735	COG3142	Participates in the control of copper homeostasis
D5F51_09740	COG3102	Protein conserved in bacteria
D5F51_09745	COG0018	arginyl-trna synthetase
D5F51_09750	COG0728	peptidoglycan biosynthetic process
D5F51_09755	COG0673	inositol 2-dehydrogenase activity
D5F51_09765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5F51_09770	COG0477	Major facilitator Superfamily
D5F51_09780	COG3381	protein complex oligomerization
D5F51_09785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5F51_09790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5F51_09815	COG0659	secondary active sulfate transmembrane transporter activity
D5F51_09820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5F51_09825	COG2912	Transglutaminase-like superfamily
D5F51_09830	COG3094	Invasion gene expression up-regulator, SirB
D5F51_09835	COG2890	protein-(glutamine-N5) methyltransferase activity
D5F51_09840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5F51_09845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D5F51_09850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D5F51_09860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5F51_09870	COG0193	aminoacyl-tRNA hydrolase activity
D5F51_09880	COG0012	GTP binding
D5F51_09900	COG4942	peptidase
D5F51_09910	COG3443	Belongs to the bacterial solute-binding protein 9 family
D5F51_09915	COG4211	Belongs to the binding-protein-dependent transport system permease family
D5F51_09920	COG1129	ABC transporter
D5F51_09935	COG0402	S-adenosylhomocysteine deaminase activity
D5F51_09945	COG1228	amidohydrolase
D5F51_09960	COG2988	succinylglutamate desuccinylase activity
D5F51_09965	COG3724	N-succinylarginine dihydrolase activity
D5F51_09975	COG3138	arginine N-succinyltransferase
D5F51_09980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5F51_09990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_09995	COG1271	oxidase subunit
D5F51_10000	COG1294	oxidase, subunit
D5F51_10010	COG3850	Histidine kinase
D5F51_10015	COG0583	DNA-binding transcription factor activity
D5F51_10025	COG0387	Pfam Sodium calcium exchanger
D5F51_10030	COG1702	phosphate starvation-inducible protein PhoH
D5F51_10045	COG3658	cytochrome
D5F51_10050	COG1215	transferase activity, transferring glycosyl groups
D5F51_10055	COG1649	PFAM Uncharacterised BCR, COG1649
D5F51_10055	COG0726	polysaccharide deacetylase
D5F51_10060	COG0457	Tetratricopeptide repeat
D5F51_10065	COG0006	proline dipeptidase activity
D5F51_10090	COG1136	(ABC) transporter
D5F51_10090	COG0577	efflux transmembrane transporter activity
D5F51_10100	COG1136	(ABC) transporter
D5F51_10100	COG0577	efflux transmembrane transporter activity
D5F51_10115	COG0672	)-iron permease
D5F51_10135	COG2066	Belongs to the glutaminase family
D5F51_10140	COG3622	Belongs to the hyi family
D5F51_10145	COG0235	Class ii aldolase
D5F51_10150	COG3395	kinase activity
D5F51_10155	COG1349	DNA-binding transcription factor activity
D5F51_10160	COG3290	protein histidine kinase activity
D5F51_10165	COG4565	transcriptional regulatory protein
D5F51_10170	COG3493	citrate carrier protein
D5F51_10185	COG0346	lactoylglutathione lyase activity
D5F51_10195	COG2223	nitrite transmembrane transporter activity
D5F51_10200	COG0561	phosphatase activity
D5F51_10210	COG3122	Protein conserved in bacteria
D5F51_10225	COG0456	acetyltransferase
D5F51_10245	COG3328	transposase activity
D5F51_10270	COG4974	Belongs to the 'phage' integrase family
D5F51_10335	COG4695	Portal protein
D5F51_10495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5F51_10500	COG0322	excinuclease ABC activity
D5F51_10505	COG2197	response regulator
D5F51_10515	COG3136	membrane protein required for alginate biosynthesis
D5F51_10525	COG0366	Alpha amylase catalytic
D5F51_10540	COG2226	methyltransferase
D5F51_10565	COG1113	amino acid transport
D5F51_10575	COG1881	PFAM PEBP family protein
D5F51_10580	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D5F51_10625	COG0506	proline dehydrogenase activity
D5F51_10625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D5F51_10625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D5F51_10655	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D5F51_10665	COG1191	sigma factor activity
D5F51_10695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5F51_10715	COG1677	Flagellar hook-basal body complex protein FliE
D5F51_10725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5F51_10730	COG1317	bacterial-type flagellum organization
D5F51_10735	COG1157	protein secretion by the type III secretion system
D5F51_10740	COG2882	bacterial-type flagellum organization
D5F51_10750	COG1580	Controls the rotational direction of flagella during chemotaxis
D5F51_10770	COG1338	Plays a role in the flagellum-specific transport system
D5F51_10785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5F51_10790	COG1256	bacterial-type flagellum assembly
D5F51_10810	COG4786	Flagellar basal body rod
D5F51_10820	COG1749	Flagellar hook protein flgE
D5F51_10825	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5F51_10830	COG1558	bacterial-type flagellum-dependent cell motility
D5F51_10835	COG1815	bacterial-type flagellum-dependent cell motility
D5F51_10845	COG2747	anti-sigma28 factor FlgM
D5F51_10850	COG3418	PFAM FlgN family protein
D5F51_10860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5F51_10865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5F51_10870	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D5F51_10875	COG0745	RESPONSE REGULATOR receiver
D5F51_10885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5F51_10890	COG0840	transmembrane signaling receptor activity
D5F51_10895	COG0840	transmembrane signaling receptor activity
D5F51_10900	COG0835	chemotaxis
D5F51_10905	COG0643	Histidine kinase
D5F51_10905	COG2198	Histidine kinase
D5F51_10910	COG1360	Flagellar Motor Protein
D5F51_10930	COG0589	response to stress
D5F51_10940	COG1285	pathogenesis
D5F51_10945	COG0840	transmembrane signaling receptor activity
D5F51_10955	COG1278	Cold shock
D5F51_10960	COG1609	Transcriptional regulator
D5F51_10965	COG3250	beta-galactosidase activity
D5F51_10980	COG1522	sequence-specific DNA binding
D5F51_11000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5F51_11010	COG0671	phosphoesterase, PA-phosphatase related
D5F51_11010	COG2453	phosphatase
D5F51_11015	COG2267	carboxylic ester hydrolase activity
D5F51_11025	COG4589	Belongs to the CDS family
D5F51_11030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5F51_11040	COG2197	response regulator
D5F51_11065	COG3228	Belongs to the MtfA family
D5F51_11075	COG0582	viral genome integration into host DNA
D5F51_11080	COG1121	(ABC) transporter
D5F51_11095	COG3328	transposase activity
D5F51_11110	COG2814	Major facilitator Superfamily
D5F51_11120	COG0667	Aldo Keto reductase
D5F51_11130	COG5002	protein histidine kinase activity
D5F51_11165	COG1396	sequence-specific DNA binding
D5F51_11180	COG0656	L-ascorbic acid biosynthetic process
D5F51_11185	COG0667	Aldo Keto reductase
D5F51_11195	COG0702	epimerase
D5F51_11210	COG2205	protein histidine kinase activity
D5F51_11210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_11220	COG3121	Chaperone
D5F51_11275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5F51_11290	COG0471	metal ion transport
D5F51_11300	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D5F51_11300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D5F51_11305	COG3051	citrate lyase alpha subunit
D5F51_11310	COG2301	Belongs to the HpcH HpaI aldolase family
D5F51_11315	COG3052	prosthetic group binding
D5F51_11320	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D5F51_11325	COG3290	protein histidine kinase activity
D5F51_11330	COG4565	transcriptional regulatory protein
D5F51_11345	COG2271	Major facilitator Superfamily
D5F51_11350	COG1840	ABC-type Fe3 transport system, periplasmic component
D5F51_11360	COG3842	ATPase activity
D5F51_11370	COG0784	Response regulator, receiver
D5F51_11370	COG0835	chemotaxis
D5F51_11375	COG0534	Mate efflux family protein
D5F51_11380	COG0137	argininosuccinate synthase activity
D5F51_11385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D5F51_11405	COG1492	cobalamin metabolic process
D5F51_11455	COG2875	Belongs to the precorrin methyltransferase family
D5F51_11465	COG2241	protein methyltransferase activity
D5F51_11470	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D5F51_11480	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D5F51_11500	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5F51_11535	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5F51_11575	COG4656	Part of a membrane complex involved in electron transport
D5F51_11585	COG4810	utilization protein
D5F51_11595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5F51_11600	COG1648	precorrin-2 dehydrogenase activity
D5F51_11600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_11605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5F51_11615	COG1879	ABC-type sugar transport system periplasmic component
D5F51_11625	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_11640	COG1289	transmembrane transporter activity
D5F51_11645	COG3320	Male sterility
D5F51_11645	COG1022	Amp-dependent synthetase and ligase
D5F51_11650	COG2925	Exonuclease
D5F51_11655	COG0531	amino acid
D5F51_11665	COG0371	Dehydrogenase
D5F51_11670	COG1129	ABC transporter
D5F51_11675	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_11680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_11690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5F51_11700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5F51_11705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5F51_11705	COG0131	Imidazoleglycerol-phosphate dehydratase
D5F51_11710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5F51_11715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5F51_11720	COG0107	imidazoleglycerol-phosphate synthase activity
D5F51_11725	COG0140	phosphoribosyl-ATP diphosphatase activity
D5F51_11725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5F51_11735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5F51_11740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5F51_11760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5F51_11775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_11825	COG1253	flavin adenine dinucleotide binding
D5F51_11830	COG3069	C4-dicarboxylate transmembrane transporter activity
D5F51_11835	COG2982	Protein involved in outer membrane biogenesis
D5F51_11850	COG0489	protein tyrosine kinase activity
D5F51_11855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5F51_11855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5F51_11875	COG2814	Major facilitator Superfamily
D5F51_11880	COG1380	Effector of murein hydrolase LrgA
D5F51_11885	COG1346	cytolysis
D5F51_11895	COG0281	malic enzyme
D5F51_11905	COG2949	membrane
D5F51_11910	COG0298	carbon dioxide binding
D5F51_11915	COG0375	protein maturation
D5F51_11920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_11925	COG0651	ATP synthesis coupled electron transport
D5F51_11930	COG0650	Formate hydrogenlyase subunit 4
D5F51_11935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5F51_11940	COG4237	Hydrogenase 4 membrane
D5F51_11945	COG0651	ATP synthesis coupled electron transport
D5F51_11950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D5F51_11950	COG3261	NADH dehydrogenase
D5F51_11955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_11960	COG3260	NADH ubiquinone oxidoreductase 20
D5F51_11970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5F51_11975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_11980	COG3383	formate dehydrogenase (NAD+) activity
D5F51_11990	COG2116	formate transmembrane transporter activity
D5F51_12015	COG2311	Membrane
D5F51_12020	COG0302	gtp cyclohydrolase
D5F51_12025	COG0477	Major facilitator Superfamily
D5F51_12030	COG0583	DNA-binding transcription factor activity
D5F51_12060	COG0577	efflux transmembrane transporter activity
D5F51_12060	COG1136	(ABC) transporter
D5F51_12070	COG0477	Major facilitator Superfamily
D5F51_12080	COG0303	'Molybdopterin
D5F51_12085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5F51_12090	COG3397	chitin binding
D5F51_12095	COG0488	(ABC) transporter
D5F51_12115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D5F51_12130	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D5F51_12145	COG4106	trans-aconitate 2-methyltransferase activity
D5F51_12150	COG0783	Belongs to the Dps family
D5F51_12155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5F51_12160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_12165	COG0765	amino acid transport
D5F51_12170	COG1126	abc transporter atp-binding protein
D5F51_12180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D5F51_12185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5F51_12200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5F51_12205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5F51_12225	COG0697	spore germination
D5F51_12245	COG1174	glycine betaine transport
D5F51_12250	COG1125	glycine betaine transport
D5F51_12255	COG1174	glycine betaine transport
D5F51_12260	COG1732	Glycine betaine
D5F51_12270	COG0673	inositol 2-dehydrogenase activity
D5F51_12275	COG2897	thiosulfate sulfurtransferase activity
D5F51_12280	COG0410	ABC transporter
D5F51_12285	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5F51_12295	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5F51_12305	COG4807	Protein conserved in bacteria
D5F51_12330	COG2261	transglycosylase associated protein
D5F51_12340	COG1403	HNH endonuclease
D5F51_12350	COG0277	FAD linked oxidase domain protein
D5F51_12355	COG1686	Belongs to the peptidase S11 family
D5F51_12365	COG2239	Acts as a magnesium transporter
D5F51_12375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5F51_12380	COG0513	Belongs to the DEAD box helicase family
D5F51_12385	COG1309	transcriptional regulator
D5F51_12390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_12395	COG1131	(ABC) transporter
D5F51_12400	COG0842	Transport permease protein
D5F51_12405	COG0842	Transport permease protein
D5F51_12410	COG0670	Belongs to the BI1 family
D5F51_12415	COG0314	molybdopterin synthase activity
D5F51_12420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5F51_12425	COG0315	cyclic pyranopterin monophosphate synthase activity
D5F51_12430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5F51_12435	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5F51_12440	COG4628	conserved protein (DUF2132)
D5F51_12445	COG0556	nucleotide-excision repair
D5F51_12455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D5F51_12460	COG2226	methyltransferase
D5F51_12465	COG0156	8-amino-7-oxononanoate synthase activity
D5F51_12470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5F51_12480	COG2706	6-phosphogluconolactonase activity
D5F51_12495	COG0561	phosphatase activity
D5F51_12505	COG4149	molybdate abc transporter
D5F51_12510	COG0725	ABC transporter, periplasmic molybdate-binding protein
D5F51_12525	COG2005	Transcriptional regulator
D5F51_12525	COG3585	molybdate ion transport
D5F51_12530	COG1119	ATPase activity
D5F51_12540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5F51_12550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5F51_12555	COG2017	converts alpha-aldose to the beta-anomer
D5F51_12565	COG0588	phosphoglycerate mutase activity
D5F51_12570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D5F51_12575	COG1230	cation diffusion facilitator family transporter
D5F51_12585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5F51_12620	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D5F51_12625	COG2885	chlorophyll binding
D5F51_12630	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_12635	COG3064	Membrane
D5F51_12635	COG3064	Membrane
D5F51_12640	COG0848	biopolymer transport protein
D5F51_12645	COG0811	peptide transport
D5F51_12650	COG0824	Thioesterase
D5F51_12655	COG3790	cyd operon protein YbgE
D5F51_12660	COG4890	Cyd operon protein YbgT
D5F51_12665	COG1294	oxidase, subunit
D5F51_12670	COG1271	oxidase subunit
D5F51_12675	COG0737	Belongs to the 5'-nucleotidase family
D5F51_12680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5F51_12690	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5F51_12695	COG0567	Dehydrogenase, E1 component
D5F51_12705	COG1053	succinate dehydrogenase
D5F51_12710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D5F51_12715	COG2009	succinate dehydrogenase
D5F51_12725	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D5F51_12740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D5F51_12745	COG1984	allophanate hydrolase subunit 2
D5F51_12750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D5F51_12755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5F51_12760	COG5212	phosphodiesterase
D5F51_12770	COG3272	Protein of unknown function (DUF1722)
D5F51_12790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D5F51_12795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D5F51_12800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D5F51_12805	COG2205	protein histidine kinase activity
D5F51_12810	COG0745	RESPONSE REGULATOR receiver
D5F51_12820	COG0033	Phosphoglucomutase
D5F51_12825	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D5F51_12830	COG0596	Alpha beta hydrolase
D5F51_12840	COG0840	transmembrane signaling receptor activity
D5F51_12850	COG0735	belongs to the Fur family
D5F51_12870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5F51_12875	COG2190	(PTS) system
D5F51_12875	COG1263	PTS System
D5F51_12875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_12880	COG0363	glucosamine-6-phosphate deaminase activity
D5F51_12885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5F51_12890	COG1846	Transcriptional regulator
D5F51_12890	COG1940	carbohydrate kinase activity
D5F51_12895	COG0647	UMP catabolic process
D5F51_12900	COG0367	asparagine synthase
D5F51_12935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5F51_12940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5F51_12945	COG1702	phosphate starvation-inducible protein PhoH
D5F51_12950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5F51_12955	COG4535	Mg2 and Co2 transporter CorC
D5F51_12960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5F51_12975	COG0765	amino acid transport
D5F51_12980	COG0765	amino acid transport
D5F51_12985	COG1126	abc transporter atp-binding protein
D5F51_12995	COG2888	peptidyl-tyrosine sulfation
D5F51_13000	COG0495	leucyl-tRNA aminoacylation
D5F51_13005	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D5F51_13010	COG1466	dna polymerase III delta subunit
D5F51_13015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5F51_13020	COG0799	negative regulation of ribosome biogenesis
D5F51_13030	COG0768	penicillin binding
D5F51_13035	COG0772	Belongs to the SEDS family
D5F51_13040	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5F51_13045	COG1686	Belongs to the peptidase S11 family
D5F51_13050	COG2921	Belongs to the UPF0250 family
D5F51_13055	COG0321	lipoyl(octanoyl) transferase activity
D5F51_13060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5F51_13065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5F51_13070	COG3706	GGDEF domain
D5F51_13075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5F51_13080	COG1278	Cold shock
D5F51_13085	COG1278	Cold shock
D5F51_13090	COG2197	response regulator
D5F51_13100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5F51_13120	COG5265	(ABC) transporter
D5F51_13125	COG2850	peptidyl-arginine hydroxylation
D5F51_13175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5F51_13240	COG1157	protein secretion by the type III secretion system
D5F51_13250	COG4789	Type iii secretion
D5F51_13405	COG0582	viral genome integration into host DNA
D5F51_13415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5F51_13420	COG2501	S4 domain
D5F51_13425	COG0215	cysteine-tRNA ligase activity
D5F51_13430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5F51_13435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_13440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D5F51_13445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5F51_13450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D5F51_13455	COG4181	ATPase activity
D5F51_13460	COG2755	lipolytic protein G-D-S-L family
D5F51_13465	COG0300	oxidoreductase activity
D5F51_13470	COG3118	belongs to the thioredoxin family
D5F51_13475	COG0330	HflC and HflK could
D5F51_13480	COG1585	Membrane protein implicated in regulation of membrane protease activity
D5F51_13485	COG0789	Transcriptional regulator
D5F51_13490	COG2217	Heavy metal translocating P-type atpase
D5F51_13495	COG3735	TraB family
D5F51_13500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D5F51_13505	COG0737	Belongs to the 5'-nucleotidase family
D5F51_13510	COG2223	nitrite transmembrane transporter activity
D5F51_13515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5F51_13515	COG4651	solute:proton antiporter activity
D5F51_13520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_13540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5F51_13545	COG0438	transferase activity, transferring glycosyl groups
D5F51_13550	COG0438	transferase activity, transferring glycosyl groups
D5F51_13555	COG1215	transferase activity, transferring glycosyl groups
D5F51_13560	COG1216	Glycosyl transferase, family 2
D5F51_13560	COG1442	glycosyl transferase family 8
D5F51_13565	COG2244	polysaccharide biosynthetic process
D5F51_13570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5F51_13575	COG0563	adenylate kinase activity
D5F51_13580	COG0326	Molecular chaperone. Has ATPase activity
D5F51_13585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5F51_13595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D5F51_13600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5F51_13605	COG2832	Protein of unknown function (DUF454)
D5F51_13620	COG3264	Mechanosensitive ion channel
D5F51_13620	COG1196	nuclear chromosome segregation
D5F51_13625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D5F51_13630	COG1309	transcriptional regulator
D5F51_13635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_13650	COG3457	Alanine racemase
D5F51_13655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5F51_13660	COG0254	rRNA binding
D5F51_13665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5F51_13670	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5F51_13675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_13680	COG1121	(ABC) transporter
D5F51_13700	COG1470	cell adhesion involved in biofilm formation
D5F51_13700	COG1388	LysM domain
D5F51_13710	COG3695	enzyme binding
D5F51_13715	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D5F51_13720	COG1946	Acyl-CoA thioesterase
D5F51_13725	COG0004	ammonium transporteR
D5F51_13730	COG0347	Belongs to the P(II) protein family
D5F51_13735	COG1132	(ABC) transporter
D5F51_13740	COG1132	(ABC) transporter
D5F51_13745	COG1522	sequence-specific DNA binding
D5F51_13755	COG0561	phosphatase activity
D5F51_13760	COG4533	DNA binding
D5F51_13765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D5F51_13770	COG0824	Thioesterase
D5F51_13775	COG1555	photosystem II stabilization
D5F51_13780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5F51_13785	COG0776	regulation of translation
D5F51_13790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5F51_13795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5F51_13805	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5F51_13815	COG0271	Belongs to the BolA IbaG family
D5F51_13825	COG3056	Lipoprotein
D5F51_13830	COG2223	nitrite transmembrane transporter activity
D5F51_13840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5F51_13845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5F51_13850	COG1845	cytochrome c oxidase, subunit III
D5F51_13855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D5F51_13860	COG0109	protoheme IX farnesyltransferase activity
D5F51_13865	COG2814	Major facilitator Superfamily
D5F51_13870	COG1666	GTP binding
D5F51_13875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5F51_13880	COG0693	protein deglycase activity
D5F51_13890	COG1840	ABC-type Fe3 transport system, periplasmic component
D5F51_13905	COG0301	tRNA thio-modification
D5F51_13905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5F51_13910	COG1722	exodeoxyribonuclease VII activity
D5F51_13915	COG0142	geranyltranstransferase activity
D5F51_13920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5F51_13925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5F51_13930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D5F51_13935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5F51_13940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5F51_13945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5F51_13945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5F51_13950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5F51_13960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5F51_13965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5F51_13970	COG1862	Preprotein translocase
D5F51_13975	COG0343	queuine tRNA-ribosyltransferase activity
D5F51_13985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5F51_13990	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D5F51_13995	COG0450	alkyl hydroperoxide reductase
D5F51_14010	COG0366	Alpha amylase catalytic
D5F51_14020	COG1114	Component of the transport system for branched-chain amino acids
D5F51_14030	COG5002	protein histidine kinase activity
D5F51_14035	COG0745	RESPONSE REGULATOR receiver
D5F51_14040	COG0420	3'-5' exonuclease activity
D5F51_14045	COG0419	ATPase involved in DNA repair
D5F51_14050	COG1940	carbohydrate kinase activity
D5F51_14055	COG2974	May be involved in recombination
D5F51_14060	COG3123	guanosine phosphorylase activity
D5F51_14065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5F51_14075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5F51_14090	COG2226	methyltransferase
D5F51_14125	COG2188	Transcriptional regulator
D5F51_14130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_14135	COG2313	pseudouridylate synthase activity
D5F51_14140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_14145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5F51_14150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5F51_14165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D5F51_14170	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5F51_14175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5F51_14190	COG2964	Protein conserved in bacteria
D5F51_14195	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5F51_14205	COG0584	glycerophosphoryl diester phosphodiesterase
D5F51_14220	COG2991	Protein conserved in bacteria
D5F51_14225	COG1477	protein flavinylation
D5F51_14230	COG2871	sodium ion transport
D5F51_14235	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_14240	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_14245	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_14250	COG1805	sodium ion transport
D5F51_14255	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_14260	COG3034	peptidoglycan biosynthetic process
D5F51_14265	COG0121	glutamine amidotransferase
D5F51_14275	COG1960	acyl-CoA dehydrogenase activity
D5F51_14280	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
D5F51_14295	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D5F51_14300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5F51_14305	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D5F51_14310	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D5F51_14315	COG0235	Class ii aldolase
D5F51_14320	COG2755	lipolytic protein G-D-S-L family
D5F51_14320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_14325	COG3328	transposase activity
D5F51_14380	COG0582	viral genome integration into host DNA
D5F51_14385	COG0436	Aminotransferase
D5F51_14400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D5F51_14415	COG0765	amino acid transport
D5F51_14460	COG2814	Major facilitator Superfamily
D5F51_14465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D5F51_14475	COG1846	Transcriptional regulator
D5F51_14480	COG1538	Outer membrane efflux protein
D5F51_14485	COG1566	PFAM secretion protein HlyD family protein
D5F51_14490	COG2814	Major facilitator Superfamily
D5F51_14495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5F51_14500	COG3118	belongs to the thioredoxin family
D5F51_14510	COG1042	CoA-binding domain protein
D5F51_14510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5F51_14510	COG0045	succinate-CoA ligase (ADP-forming) activity
D5F51_14515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5F51_14520	COG5544	Lipoprotein
D5F51_14555	COG0542	response to heat
D5F51_14565	COG0564	pseudouridine synthase activity
D5F51_14575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5F51_14580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5F51_14585	COG1605	Chorismate mutase
D5F51_14585	COG0077	Prephenate dehydratase
D5F51_14590	COG0287	Prephenate dehydrogenase
D5F51_14590	COG1605	Chorismate mutase
D5F51_14595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D5F51_14600	COG3279	Response regulator of the LytR AlgR family
D5F51_14605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D5F51_14610	COG3137	Salt-induced outer membrane protein
D5F51_14615	COG0335	large ribosomal subunit rRNA binding
D5F51_14620	COG0336	Belongs to the RNA methyltransferase TrmD family
D5F51_14625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5F51_14630	COG0228	four-way junction DNA binding
D5F51_14635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5F51_14640	COG4137	Cytochrome C assembly protein
D5F51_14645	COG4536	flavin adenine dinucleotide binding
D5F51_14650	COG1854	S-ribosylhomocysteine lyase activity
D5F51_14655	COG2918	glutathione biosynthetic process
D5F51_14660	COG1238	metal cluster binding
D5F51_14665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_14695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5F51_14700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5F51_14705	COG2137	regulation of response to DNA damage stimulus
D5F51_14710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5F51_14735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5F51_14740	COG3958	Transketolase
D5F51_14745	COG3959	Transketolase, thiamine diphosphate binding domain
D5F51_14750	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_14755	COG1129	ABC transporter
D5F51_14765	COG1609	Transcriptional regulator
D5F51_14770	COG3381	protein complex oligomerization
D5F51_14775	COG3302	dmso reductase anchor subunit
D5F51_14780	COG0437	4 iron, 4 sulfur cluster binding
D5F51_14785	COG0243	molybdopterin cofactor binding
D5F51_14790	COG0235	Class ii aldolase
D5F51_14795	COG1349	DNA-binding transcription factor activity
D5F51_14805	COG1129	ABC transporter
D5F51_14810	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_14820	COG3623	hexulose-6-phosphate isomerase
D5F51_14825	COG1070	Carbohydrate kinase
D5F51_14830	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5F51_14830	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5F51_14840	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5F51_14850	COG1137	ATPase activity
D5F51_14855	COG0410	ABC transporter
D5F51_14915	COG0640	Transcriptional regulator
D5F51_14920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5F51_14925	COG3158	transport of potassium into the cell
D5F51_14945	COG1126	abc transporter atp-binding protein
D5F51_14955	COG0765	amino acid transport
D5F51_14985	COG3048	D-serine ammonia-lyase activity
D5F51_14990	COG2610	gluconate transmembrane transporter activity
D5F51_14995	COG0583	DNA-binding transcription factor activity
D5F51_15000	COG4608	Belongs to the ABC transporter superfamily
D5F51_15005	COG0444	Belongs to the ABC transporter superfamily
D5F51_15015	COG0601	transmembrane transport
D5F51_15020	COG0747	negative chemotaxis
D5F51_15025	COG4948	Mandelate Racemase Muconate Lactonizing
D5F51_15030	COG1858	cytochrome C peroxidase
D5F51_15035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5F51_15040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_15045	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_15065	COG1538	Outer membrane efflux protein
D5F51_15070	COG0577	efflux transmembrane transporter activity
D5F51_15070	COG1136	(ABC) transporter
D5F51_15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_15090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5F51_15105	COG3539	Fimbrial protein
D5F51_15110	COG3539	Fimbrial protein
D5F51_15120	COG3121	Chaperone
D5F51_15125	COG3188	usher protein
D5F51_15175	COG2831	hemolysin activation secretion protein
D5F51_15205	COG3210	domain, Protein
D5F51_15245	COG3188	usher protein
D5F51_15250	COG3121	Chaperone
D5F51_15255	COG3539	Fimbrial protein
D5F51_15260	COG2824	Alkylphosphonate utilization operon protein PhnA
D5F51_15270	COG1695	Transcriptional regulator
D5F51_15280	COG2723	6-phospho-beta-galactosidase activity
D5F51_15290	COG1609	Transcriptional regulator
D5F51_15295	COG2353	YceI-like domain
D5F51_15300	COG3038	cytochrome b561
D5F51_15305	COG1902	pentaerythritol trinitrate reductase activity
D5F51_15320	COG1127	ABC transporter
D5F51_15325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5F51_15345	COG0531	amino acid
D5F51_15350	COG2951	lytic endotransglycosylase activity
D5F51_15370	COG1280	lysine exporter protein (LysE YggA)
D5F51_15385	COG2723	6-phospho-beta-galactosidase activity
D5F51_15400	COG0243	molybdopterin cofactor binding
D5F51_15405	COG0437	4 iron, 4 sulfur cluster binding
D5F51_15410	COG3302	dmso reductase anchor subunit
D5F51_15415	COG3381	protein complex oligomerization
D5F51_15425	COG1598	PFAM Uncharacterised protein family UPF0150
D5F51_15435	COG3038	cytochrome b561
D5F51_15440	COG0436	Aminotransferase
D5F51_15455	COG3275	phosphorelay sensor kinase activity
D5F51_15460	COG3279	Response regulator of the LytR AlgR family
D5F51_15465	COG2223	nitrite transmembrane transporter activity
D5F51_15470	COG0837	glucose binding
D5F51_15485	COG3961	Belongs to the TPP enzyme family
D5F51_15490	COG0667	Aldo Keto reductase
D5F51_15500	COG1914	H( )-stimulated, divalent metal cation uptake system
D5F51_15505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_15530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5F51_15560	COG3530	Putative quorum-sensing-regulated virulence factor
D5F51_15565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5F51_15580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5F51_15585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_15590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5F51_15595	COG2190	(PTS) system
D5F51_15600	COG2205	protein histidine kinase activity
D5F51_15605	COG0745	RESPONSE REGULATOR receiver
D5F51_15610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_15630	COG4208	sulfate ABC transporter
D5F51_15635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D5F51_15650	COG1737	Transcriptional regulator
D5F51_15655	COG2731	YhcH YjgK YiaL family protein
D5F51_15670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5F51_15675	COG2837	iron assimilation
D5F51_15685	COG3111	PFAM Bacterial OB fold (BOF) protein
D5F51_15695	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_15700	COG2897	thiosulfate sulfurtransferase activity
D5F51_15720	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_15725	COG1129	ABC transporter
D5F51_15735	COG0456	acetyltransferase
D5F51_15740	COG0408	coproporphyrinogen oxidase activity
D5F51_15755	COG0494	nUDIX hydrolase
D5F51_15760	COG3005	denitrification pathway
D5F51_15765	COG3043	anaerobic respiration
D5F51_15770	COG0243	molybdopterin cofactor binding
D5F51_15775	COG3062	negative regulation of establishment of protein localization
D5F51_15785	COG2197	response regulator
D5F51_15795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_15805	COG1393	Belongs to the ArsC family
D5F51_15810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5F51_15815	COG1876	peptidase activity
D5F51_15825	COG0400	carboxylic ester hydrolase activity
D5F51_15830	COG1444	tRNA N-acetyltransferase activity
D5F51_15835	COG2707	UPF0756 membrane protein
D5F51_15840	COG2321	neutral zinc metallopeptidase
D5F51_15845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5F51_15850	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D5F51_15855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5F51_15860	COG2716	regulation of RNA biosynthetic process
D5F51_15865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5F51_15870	COG0628	permease
D5F51_15875	COG4783	chaperone-mediated protein folding
D5F51_15880	COG1393	Belongs to the ArsC family
D5F51_15885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5F51_15890	COG2233	PERMEase
D5F51_15895	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5F51_15900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5F51_15905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5F51_15910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5F51_15920	COG0581	inorganic phosphate transmembrane transporter activity
D5F51_15930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D5F51_15935	COG0248	Ppx GppA phosphatase
D5F51_15945	COG2239	Acts as a magnesium transporter
D5F51_15950	COG5002	protein histidine kinase activity
D5F51_15950	COG3447	MASE1 domain protein
D5F51_15950	COG5001	Diguanylate cyclase
D5F51_15955	COG0443	Heat shock 70 kDa protein
D5F51_15965	COG3121	Chaperone
D5F51_15980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_15990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_15995	COG0477	Major facilitator Superfamily
D5F51_16000	COG2205	protein histidine kinase activity
D5F51_16005	COG0745	RESPONSE REGULATOR receiver
D5F51_16010	COG3422	double-strand break repair
D5F51_16020	COG1597	lipid kinase activity
D5F51_16025	COG3730	PTS system glucitol sorbitol-specific
D5F51_16040	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_16045	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_16050	COG1349	DNA-binding transcription factor activity
D5F51_16075	COG0351	phosphomethylpyrimidine kinase
D5F51_16090	COG0519	Catalyzes the synthesis of GMP from XMP
D5F51_16090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5F51_16095	COG0516	GMP reductase activity
D5F51_16095	COG0517	IMP dehydrogenase activity
D5F51_16100	COG1570	exodeoxyribonuclease VII activity
D5F51_16105	COG1645	bacterial-type flagellum-dependent swarming motility
D5F51_16115	COG1160	GTP binding
D5F51_16120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5F51_16125	COG2976	Protein conserved in bacteria
D5F51_16130	COG0124	histidyl-tRNA synthetase
D5F51_16135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5F51_16140	COG1426	Protein conserved in bacteria
D5F51_16150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5F51_16165	COG4953	penicillin-binding protein 1C
D5F51_16170	COG2373	Large extracellular alpha-helical protein
D5F51_16195	COG2975	iron-sulfur cluster assembly
D5F51_16200	COG0633	Ferredoxin
D5F51_16205	COG0443	Heat shock 70 kDa protein
D5F51_16210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5F51_16225	COG0822	iron-sulfur transferase activity
D5F51_16235	COG1959	2 iron, 2 sulfur cluster binding
D5F51_16240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D5F51_16245	COG0483	inositol monophosphate 1-phosphatase activity
D5F51_16250	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D5F51_16255	COG3683	transport system, periplasmic component
D5F51_16260	COG3711	transcriptional antiterminator
D5F51_16265	COG2814	Major facilitator Superfamily
D5F51_16270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5F51_16275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_16275	COG1017	nitric oxide dioxygenase activity
D5F51_16280	COG2188	Transcriptional regulator
D5F51_16290	COG3457	Alanine racemase
D5F51_16295	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D5F51_16310	COG0347	Belongs to the P(II) protein family
D5F51_16315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D5F51_16315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5F51_16320	COG2204	response regulator
D5F51_16325	COG3170	Tfp pilus assembly protein FimV
D5F51_16330	COG2205	protein histidine kinase activity
D5F51_16350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5F51_16355	COG0590	tRNA wobble adenosine to inosine editing
D5F51_16365	COG0560	Phosphoserine phosphatase
D5F51_16375	COG1737	Transcriptional regulator
D5F51_16380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_16385	COG2610	gluconate transmembrane transporter activity
D5F51_16390	COG0736	holo-[acyl-carrier-protein] synthase activity
D5F51_16395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D5F51_16400	COG1381	Involved in DNA repair and RecF pathway recombination
D5F51_16405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5F51_16415	COG0681	Belongs to the peptidase S26 family
D5F51_16420	COG0481	GTPase activity
D5F51_16430	COG3086	response to oxidative stress
D5F51_16440	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D5F51_16450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5F51_16455	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5F51_16460	COG0513	Belongs to the DEAD box helicase family
D5F51_16475	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D5F51_16480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D5F51_16485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5F51_16490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5F51_16495	COG0497	DNA recombination
D5F51_16500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5F51_16510	COG2867	negative regulation of translational initiation
D5F51_16525	COG0582	viral genome integration into host DNA
D5F51_16640	COG3188	usher protein
D5F51_16645	COG3121	Chaperone
D5F51_16705	COG2197	response regulator
D5F51_16715	COG3394	polysaccharide catabolic process
D5F51_16720	COG1917	Cupin 2, conserved barrel domain protein
D5F51_16720	COG2169	Transcriptional regulator
D5F51_16725	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5F51_16730	COG2723	6-phospho-beta-galactosidase activity
D5F51_16735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5F51_16740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5F51_16745	COG2133	pyrroloquinoline quinone binding
D5F51_16750	COG0667	Aldo Keto reductase
D5F51_16760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5F51_16765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5F51_16775	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D5F51_16780	COG4413	Urea transporter
D5F51_16785	COG0829	nickel cation binding
D5F51_16790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5F51_16800	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5F51_16805	COG0804	urea catabolic process
D5F51_16835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_16845	COG0747	negative chemotaxis
D5F51_16905	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D5F51_16910	COG4575	ribosome binding
D5F51_16915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_16920	COG1780	Probably involved in ribonucleotide reductase function
D5F51_16930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5F51_16940	COG4176	ABC-type proline glycine betaine transport system permease component
D5F51_16945	COG2113	Glycine betaine
D5F51_16955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5F51_16965	COG2226	methyltransferase
D5F51_16970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5F51_16975	COG1388	LysM domain
D5F51_16975	COG0741	lytic transglycosylase activity
D5F51_16980	COG3021	interspecies interaction between organisms
D5F51_16985	COG2814	Major facilitator Superfamily
D5F51_16990	COG0583	DNA-binding transcription factor activity
D5F51_16995	COG0656	L-ascorbic acid biosynthetic process
D5F51_17035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5F51_17045	COG2011	ABC-type metal ion transport system permease component
D5F51_17050	COG1464	Belongs to the NlpA lipoprotein family
D5F51_17060	COG1720	tRNA m6t6A37 methyltransferase activity
D5F51_17065	COG0442	prolyl-tRNA aminoacylation
D5F51_17070	COG3015	lipoprotein NlpE involved in copper resistance
D5F51_17080	COG4681	YaeQ
D5F51_17090	COG4568	rho-dependent transcription termination
D5F51_17100	COG0037	tRNA processing
D5F51_17105	COG0346	lactoylglutathione lyase activity
D5F51_17125	COG0825	malonyl-CoA metabolic process
D5F51_17130	COG0587	DNA-directed DNA polymerase activity
D5F51_17135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5F51_17140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_17145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_17150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5F51_17155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_17160	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D5F51_17170	COG0750	zinc metalloprotease
D5F51_17175	COG0575	Belongs to the CDS family
D5F51_17180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5F51_17185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5F51_17195	COG0528	UMP kinase activity
D5F51_17200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5F51_17205	COG0052	Belongs to the universal ribosomal protein uS2 family
D5F51_17215	COG0024	Methionine aminopeptidase
D5F51_17220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D5F51_17225	COG2171	N-acyltransferase activity
D5F51_17240	COG0564	pseudouridine synthase activity
D5F51_17245	COG3098	single-species biofilm formation
D5F51_17255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5F51_17255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5F51_17260	COG1611	Belongs to the LOG family
D5F51_17265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5F51_17270	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D5F51_17275	COG2363	Small membrane protein
D5F51_17280	COG0583	DNA-binding transcription factor activity
D5F51_17290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5F51_17295	COG2166	iron-sulfur cluster assembly
D5F51_17300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5F51_17305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D5F51_17325	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5F51_17330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D5F51_17330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5F51_17335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5F51_17340	COG1074	ATP-dependent DNA helicase activity
D5F51_17345	COG1025	Belongs to the peptidase M16 family
D5F51_17350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5F51_17355	COG4967	type IV pilus modification protein PilV
D5F51_17380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5F51_17390	COG1051	belongs to the nudix hydrolase family
D5F51_17400	COG3066	DNA modification
D5F51_17405	COG0861	Integral membrane protein TerC family
D5F51_17410	COG0667	Aldo Keto reductase
D5F51_17415	COG0477	Major facilitator Superfamily
D5F51_17420	COG0204	Acyl-transferase
D5F51_17420	COG0318	PFAM AMP-dependent synthetase and ligase
D5F51_17430	COG1609	Transcriptional regulator
D5F51_17435	COG0019	diaminopimelate decarboxylase activity
D5F51_17440	COG0583	DNA-binding transcription factor activity
D5F51_17445	COG2814	Major facilitator Superfamily
D5F51_17450	COG0583	DNA-binding transcription factor activity
D5F51_17505	COG2165	general secretion pathway protein
D5F51_17515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_17540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5F51_17580	COG0210	DNA helicase
D5F51_17585	COG0582	viral genome integration into host DNA
D5F51_17595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D5F51_17605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5F51_17610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5F51_17615	COG4974	Belongs to the 'phage' integrase family
D5F51_17620	COG0716	FMN binding
D5F51_17625	COG4452	Inner membrane protein CreD
D5F51_17630	COG2205	protein histidine kinase activity
D5F51_17635	COG0745	RESPONSE REGULATOR receiver
D5F51_17645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D5F51_17650	COG0354	folic acid binding
D5F51_17655	COG1272	protein, Hemolysin III
D5F51_17665	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_17675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5F51_17675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5F51_17680	COG0509	glycine decarboxylation via glycine cleavage system
D5F51_17685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5F51_17690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5F51_17695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5F51_17700	COG0006	proline dipeptidase activity
D5F51_17705	COG3079	Belongs to the UPF0149 family
D5F51_17710	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D5F51_17720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D5F51_17725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5F51_17730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5F51_17735	COG0583	DNA-binding transcription factor activity
D5F51_17745	COG1279	arginine transmembrane transporter activity
D5F51_17760	COG0191	fructose-bisphosphate aldolase activity
D5F51_17765	COG0126	phosphoglycerate kinase activity
D5F51_17770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5F51_17780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5F51_17785	COG0501	Belongs to the peptidase M48B family
D5F51_17795	COG1166	arginine decarboxylase activity
D5F51_17815	COG0640	Transcriptional regulator
D5F51_17820	COG3091	SprT-like family
D5F51_17825	COG2356	endonuclease I
D5F51_17830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5F51_17835	COG0189	ligase activity
D5F51_17840	COG1678	Uncharacterized ACR, COG1678
D5F51_17845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5F51_17850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5F51_17860	COG2805	Type II/IV secretion system protein
D5F51_17865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5F51_17870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5F51_17875	COG0762	integral membrane protein
D5F51_17880	COG1872	DUF167
D5F51_17885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5F51_17890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5F51_17900	COG2066	Belongs to the glutaminase family
D5F51_17905	COG3171	Protein conserved in bacteria
D5F51_17915	COG2814	Major facilitator Superfamily
D5F51_17925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5F51_17930	COG1194	a g-specific adenine glycosylase
D5F51_17935	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D5F51_17940	COG0741	lytic transglycosylase activity
D5F51_17950	COG1982	Orn Lys Arg decarboxylase major
D5F51_17960	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5F51_17990	COG1074	ATP-dependent DNA helicase activity
D5F51_17995	COG1196	nuclear chromosome segregation
D5F51_18160	COG2885	chlorophyll binding
D5F51_18340	COG0741	lytic transglycosylase activity
D5F51_18355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_18395	COG0629	single-stranded DNA binding
D5F51_18435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5F51_18445	COG0305	Participates in initiation and elongation during chromosome replication
D5F51_18455	COG1192	Involved in chromosome partitioning
D5F51_18480	COG0583	DNA-binding transcription factor activity
D5F51_18585	COG2885	chlorophyll binding
D5F51_18610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5F51_18675	COG1157	protein secretion by the type III secretion system
D5F51_18780	COG2205	protein histidine kinase activity
D5F51_18800	COG3031	protein transport across the cell outer membrane
D5F51_18810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_18820	COG2165	general secretion pathway protein
D5F51_18855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D5F51_18865	COG3397	chitin binding
D5F51_18900	COG1289	transmembrane transporter activity
D5F51_18925	COG0024	Methionine aminopeptidase
D5F51_18930	COG4604	ABC transporter, ATP-binding protein
D5F51_18935	COG4605	iron ion homeostasis
D5F51_18945	COG4607	ABC-type enterochelin transport system periplasmic component
D5F51_18950	COG1017	nitric oxide dioxygenase activity
D5F51_18950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_18960	COG0477	Major facilitator Superfamily
D5F51_18965	COG1609	Transcriptional regulator
D5F51_18975	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5F51_18990	COG0477	Major facilitator Superfamily
D5F51_19010	COG0583	DNA-binding transcription factor activity
D5F51_19025	COG0471	metal ion transport
D5F51_19055	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D5F51_19060	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D5F51_19065	COG0309	Hydrogenase expression formation protein (HypE)
D5F51_19070	COG0409	Hydrogenase expression formation protein
D5F51_19075	COG0298	carbon dioxide binding
D5F51_19080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5F51_19085	COG0375	protein maturation
D5F51_19090	COG1773	rubredoxin
D5F51_19095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5F51_19100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D5F51_19105	COG5557	Pfam Polysulphide reductase, NrfD
D5F51_19110	COG0437	4 iron, 4 sulfur cluster binding
D5F51_19115	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D5F51_19120	COG3133	Outer membrane lipoprotein
D5F51_19150	COG2204	response regulator
D5F51_19155	COG0840	transmembrane signaling receptor activity
D5F51_19160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_19165	COG2271	Major facilitator Superfamily
D5F51_19170	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_19175	COG1535	isochorismatase
D5F51_19175	COG3433	isochorismatase activity
D5F51_19180	COG1021	2,3-dihydroxybenzoate-AMP ligase
D5F51_19185	COG1169	isochorismate synthase
D5F51_19190	COG4592	Periplasmic binding protein
D5F51_19200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_19205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_19210	COG1120	ATPase activity
D5F51_19215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5F51_19230	COG4774	siderophore transport
D5F51_19240	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_19250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_19255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_19280	COG4964	Belongs to the GSP D family
D5F51_19330	COG0848	biopolymer transport protein
D5F51_19335	COG0811	peptide transport
D5F51_19345	COG0586	Pfam SNARE associated Golgi protein
D5F51_19350	COG2207	Transcriptional regulator
D5F51_19355	COG1979	alcohol dehydrogenase
D5F51_19360	COG0656	L-ascorbic acid biosynthetic process
D5F51_19370	COG2132	Multicopper oxidase
D5F51_19375	COG0204	Acyl-transferase
D5F51_19385	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5F51_19390	COG0583	DNA-binding transcription factor activity
D5F51_19395	COG0187	DNA topoisomerase II activity
D5F51_19400	COG3150	esterase
D5F51_19405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D5F51_19410	COG3151	Protein conserved in bacteria
D5F51_19415	COG0494	nUDIX hydrolase
D5F51_19420	COG1538	Outer membrane efflux protein
D5F51_19430	COG0754	glutathionylspermidine amidase activity
D5F51_19435	COG3384	dioxygenase
D5F51_19440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5F51_19450	COG0531	amino acid
D5F51_19455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5F51_19455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5F51_19460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5F51_19465	COG3025	triphosphatase activity
D5F51_19470	COG4991	sh3 domain protein
D5F51_19475	COG0617	tRNA 3'-terminal CCA addition
D5F51_19480	COG1968	undecaprenyl-diphosphatase activity
D5F51_19485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D5F51_19490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5F51_19495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5F51_19505	COG0358	DNA primase activity
D5F51_19510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5F51_19520	COG3876	Protein conserved in bacteria
D5F51_19530	COG1472	Belongs to the glycosyl hydrolase 3 family
D5F51_19540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5F51_19545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_19545	COG1263	PTS System
D5F51_19550	COG2066	Belongs to the glutaminase family
D5F51_19555	COG0531	amino acid
D5F51_19560	COG0076	glutamate decarboxylase activity
D5F51_19570	COG2814	Major facilitator Superfamily
D5F51_19575	COG3247	response to pH
D5F51_19585	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5F51_19585	COG1902	pentaerythritol trinitrate reductase activity
D5F51_19590	COG2813	Specifically methylates the guanine in position
D5F51_19600	COG1451	nucleotide metabolic process
D5F51_19605	COG0673	inositol 2-dehydrogenase activity
D5F51_19615	COG0861	Integral membrane protein TerC family
D5F51_19620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D5F51_19630	COG2721	sulfolactate sulfo-lyase activity
D5F51_19635	COG0246	Mannitol dehydrogenase
D5F51_19640	COG1904	glucuronate isomerase
D5F51_19645	COG2271	Major facilitator Superfamily
D5F51_19660	COG0586	Pfam SNARE associated Golgi protein
D5F51_19675	COG4575	ribosome binding
D5F51_19680	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
D5F51_19690	COG2259	Doxx family
D5F51_19695	COG0435	Glutathione S-transferase
D5F51_19700	COG0583	DNA-binding transcription factor activity
D5F51_19705	COG1741	Belongs to the pirin family
D5F51_19710	COG1064	alcohol dehydrogenase
D5F51_19715	COG4221	oxidoreductase activity
D5F51_19725	COG0667	Aldo Keto reductase
D5F51_19760	COG3469	chitinase activity
D5F51_19765	COG3397	chitin binding
D5F51_19785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5F51_19795	COG0792	nuclease activity
D5F51_19800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5F51_19805	COG2823	Periplasmic or secreted lipoprotein
D5F51_19810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5F51_19815	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D5F51_19825	COG0784	Response regulator, receiver
D5F51_19825	COG5002	protein histidine kinase activity
D5F51_19825	COG2198	Histidine kinase
D5F51_19835	COG1242	4 iron, 4 sulfur cluster binding
D5F51_19840	COG0069	glutamate synthase activity
D5F51_19840	COG0070	glutamate synthase
D5F51_19840	COG0067	glutamate synthase
D5F51_19845	COG0493	'glutamate synthase
D5F51_19855	COG2969	positive regulation of protein catabolic process
D5F51_19860	COG0625	glutathione transferase activity
D5F51_19865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5F51_19870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5F51_19875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D5F51_19880	COG3105	Protein conserved in bacteria
D5F51_19885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5F51_19890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5F51_19895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5F51_19900	COG5007	Belongs to the BolA IbaG family
D5F51_19905	COG3113	response to antibiotic
D5F51_19910	COG2854	intermembrane phospholipid transfer
D5F51_19915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5F51_19920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5F51_19925	COG1127	ABC transporter
D5F51_19930	COG0530	calcium, potassium:sodium antiporter activity
D5F51_19935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D5F51_19935	COG0517	IMP dehydrogenase activity
D5F51_19940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5F51_19945	COG3117	lipopolysaccharide transmembrane transporter activity
D5F51_19950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D5F51_19955	COG1137	ATPase activity
D5F51_19960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5F51_19970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_19975	COG1660	Displays ATPase and GTPase activities
D5F51_19980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_19985	COG0540	Belongs to the ATCase OTCase family
D5F51_19990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D5F51_20000	COG2308	Evidence 4 Homologs of previously reported genes of
D5F51_20020	COG0366	Alpha amylase catalytic
D5F51_20025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_20025	COG1263	PTS System
D5F51_20030	COG1609	Transcriptional regulator
D5F51_20035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5F51_20040	COG3711	transcriptional antiterminator
D5F51_20040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_20045	COG2706	6-phosphogluconolactonase activity
D5F51_20060	COG3964	amidohydrolase
D5F51_20090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5F51_20095	COG3783	Cytochrome b(562)
D5F51_20100	COG0312	modulator of DNA gyrase
D5F51_20105	COG3028	Belongs to the UPF0307 family
D5F51_20110	COG2732	(Barnase) inhibitor
D5F51_20125	COG1289	transmembrane transporter activity
D5F51_20130	COG1566	PFAM secretion protein HlyD family protein
D5F51_20140	COG0583	DNA-binding transcription factor activity
D5F51_20145	COG0312	modulator of DNA gyrase
D5F51_20150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5F51_20155	COG3164	Protein of unknown function
D5F51_20160	COG1530	ribonuclease E activity
D5F51_20170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D5F51_20175	COG1792	Involved in formation and maintenance of cell shape
D5F51_20180	COG1077	Cell shape determining protein MreB Mrl
D5F51_20185	COG2200	EAL domain
D5F51_20185	COG2199	diguanylate cyclase activity
D5F51_20190	COG0604	alcohol dehydrogenase
D5F51_20200	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5F51_20205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5F51_20210	COG0511	ligase activity, forming carbon-carbon bonds
D5F51_20215	COG0439	Biotin carboxylase
D5F51_20220	COG3924	membrane
D5F51_20225	COG4145	pantothenate transmembrane transporter activity
D5F51_20230	COG2264	protein methyltransferase activity
D5F51_20235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5F51_20240	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D5F51_20245	COG3706	GGDEF domain
D5F51_20250	COG3133	Outer membrane lipoprotein
D5F51_20255	COG1278	Cold shock
D5F51_20260	COG1278	Cold shock
D5F51_20270	COG0471	metal ion transport
D5F51_20275	COG1560	Kdo2-lipid A biosynthetic process
D5F51_20285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_20290	COG4597	amino acid ABC transporter
D5F51_20295	COG0765	amino acid transport
D5F51_20300	COG1126	abc transporter atp-binding protein
D5F51_20310	COG1380	Effector of murein hydrolase LrgA
D5F51_20315	COG0583	DNA-binding transcription factor activity
D5F51_20320	COG0025	NhaP-type Na H and K H
D5F51_20325	COG2252	PERMEase
D5F51_20340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5F51_20345	COG2315	Protein conserved in bacteria
D5F51_20350	COG1448	Aminotransferase
D5F51_20355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5F51_20360	COG0305	Participates in initiation and elongation during chromosome replication
D5F51_20365	COG0604	alcohol dehydrogenase
D5F51_20380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5F51_20395	COG0735	belongs to the Fur family
D5F51_20400	COG3237	CsbD-like
D5F51_20405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5F51_20410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5F51_20415	COG2937	Belongs to the GPAT DAPAT family
D5F51_20420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5F51_20425	COG3161	chorismate lyase activity
D5F51_20440	COG4580	involved in the transport of maltose and maltodextrins
D5F51_20455	COG2182	Extracellular solute-binding protein
D5F51_20460	COG1175	transmembrane transport
D5F51_20465	COG3833	ABC-type maltose transport systems, permease component
D5F51_20480	COG0527	aspartate kinase activity
D5F51_20505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D5F51_20510	COG2224	Isocitrate lyase
D5F51_20515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5F51_20520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D5F51_20565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5F51_20570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5F51_20575	COG0009	L-threonylcarbamoyladenylate synthase
D5F51_20580	COG0551	DNA topoisomerase type I activity
D5F51_20590	COG0758	DNA mediated transformation
D5F51_20595	COG0242	peptide deformylase activity
D5F51_20600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5F51_20605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5F51_20605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5F51_20610	COG0569	domain protein
D5F51_20615	COG1970	mechanosensitive ion channel activity
D5F51_20620	COG3036	rescue of stalled ribosome
D5F51_20625	COG0789	Transcriptional regulator
D5F51_20635	COG0203	ribosomal protein L17
D5F51_20640	COG0202	RNA polymerase activity
D5F51_20645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5F51_20650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5F51_20655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5F51_20660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5F51_20665	COG0201	protein transport
D5F51_20670	COG0200	Binds to the 23S rRNA
D5F51_20675	COG1841	ribosomal large subunit assembly
D5F51_20680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5F51_20690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5F51_20700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5F51_20705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5F51_20715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5F51_20720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5F51_20725	COG0255	Belongs to the universal ribosomal protein uL29 family
D5F51_20730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5F51_20735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5F51_20745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5F51_20755	COG0089	rRNA binding
D5F51_20760	COG0088	Forms part of the polypeptide exit tunnel
D5F51_20765	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5F51_20770	COG0051	transcription antitermination factor activity, RNA binding
D5F51_20800	COG0049	tRNA binding
D5F51_20805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D5F51_20810	COG2168	tRNA wobble position uridine thiolation
D5F51_20815	COG2923	Belongs to the DsrF TusC family
D5F51_20825	COG2964	Protein conserved in bacteria
D5F51_20830	COG0545	Peptidyl-prolyl cis-trans isomerase
D5F51_20835	COG2900	Belongs to the SlyX family
D5F51_20840	COG1047	Peptidyl-prolyl cis-trans
D5F51_20845	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D5F51_20855	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5F51_20860	COG0488	(ABC) transporter
D5F51_20870	COG2175	clavaminate synthase activity
D5F51_20875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5F51_20885	COG4521	taurine ABC transporter
D5F51_20900	COG0429	hydrolase of the alpha beta-hydrolase fold
D5F51_20905	COG3089	Belongs to the UPF0270 family
D5F51_20910	COG3954	Phosphoribulokinase
D5F51_20915	COG1765	OsmC-like protein
D5F51_20925	COG1289	transmembrane transporter activity
D5F51_20940	COG0433	COG0433 Predicted ATPase
D5F51_20945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5F51_20950	COG1486	melibiose metabolic process
D5F51_20970	COG0738	Major facilitator superfamily
D5F51_20975	COG0402	S-adenosylhomocysteine deaminase activity
D5F51_20980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5F51_20985	COG2146	nitrite reductase [NAD(P)H] activity
D5F51_20995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_20995	COG1648	precorrin-2 dehydrogenase activity
D5F51_21000	COG0180	Tryptophanyl-tRNA synthetase
D5F51_21010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5F51_21030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5F51_21035	COG4796	Type ii and iii secretion system protein
D5F51_21060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5F51_21065	COG0494	nUDIX hydrolase
D5F51_21075	COG1011	Hydrolase
D5F51_21080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5F51_21090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D5F51_21100	COG0745	RESPONSE REGULATOR receiver
D5F51_21105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5F51_21110	COG2183	response to ionizing radiation
D5F51_21125	COG1918	ferrous iron import across plasma membrane
D5F51_21145	COG0596	Alpha beta hydrolase
D5F51_21150	COG1040	competence protein
D5F51_21155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5F51_21155	COG0316	Belongs to the HesB IscA family
D5F51_21160	COG1640	4-alpha-glucanotransferase
D5F51_21165	COG0058	SHG alpha-glucan phosphorylase activity
D5F51_21170	COG2909	trisaccharide binding
D5F51_21185	COG0705	Rhomboid family
D5F51_21190	COG1349	DNA-binding transcription factor activity
D5F51_21195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5F51_21200	COG0058	SHG alpha-glucan phosphorylase activity
D5F51_21205	COG0297	glycogen (starch) synthase activity
D5F51_21215	COG1523	belongs to the glycosyl hydrolase 13 family
D5F51_21220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D5F51_21225	COG3275	phosphorelay sensor kinase activity
D5F51_21230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5F51_21235	COG2095	MarC family integral membrane protein
D5F51_21240	COG3265	gluconokinase activity
D5F51_21245	COG2610	gluconate transmembrane transporter activity
D5F51_21250	COG1609	Transcriptional regulator
D5F51_21255	COG1741	Belongs to the pirin family
D5F51_21265	COG1247	-acetyltransferase
D5F51_21270	COG1082	Xylose isomerase domain protein TIM barrel
D5F51_21275	COG0673	inositol 2-dehydrogenase activity
D5F51_21285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_21295	COG3718	enzyme involved in inositol metabolism
D5F51_21305	COG2814	Major facilitator Superfamily
D5F51_21315	COG0561	phosphatase activity
D5F51_21330	COG0583	DNA-binding transcription factor activity
D5F51_21335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_21335	COG1648	precorrin-2 dehydrogenase activity
D5F51_21345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5F51_21355	COG4865	methylaspartate mutase activity
D5F51_21360	COG3799	methylaspartate ammonia-lyase activity
D5F51_21375	COG1301	dicarboxylic acid transport
D5F51_21380	COG3344	reverse transcriptase
D5F51_21440	COG2081	HI0933 family
D5F51_21445	COG0306	phosphate transporter
D5F51_21455	COG0589	response to stress
D5F51_21470	COG0742	ribosomal rna small subunit methyltransferase
D5F51_21485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D5F51_21490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_21500	COG1295	ribonuclease BN
D5F51_21505	COG0477	Major facilitator Superfamily
D5F51_21510	COG2134	cdp-diacylglycerol pyrophosphatase
D5F51_21515	COG2982	Protein involved in outer membrane biogenesis
D5F51_21520	COG2200	EAL domain
D5F51_21525	COG1942	4-Oxalocrotonate Tautomerase
D5F51_21530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_21535	COG0612	Peptidase, M16
D5F51_21540	COG1301	dicarboxylic acid transport
D5F51_21555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5F51_21560	COG2200	EAL domain
D5F51_21560	COG2199	diguanylate cyclase activity
D5F51_21570	COG3118	belongs to the thioredoxin family
D5F51_21570	COG0457	Tetratricopeptide repeat
D5F51_21575	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D5F51_21585	COG1215	transferase activity, transferring glycosyl groups
D5F51_21590	COG1192	Involved in chromosome partitioning
D5F51_21610	COG2194	sulfuric ester hydrolase activity
D5F51_21620	COG4608	Belongs to the ABC transporter superfamily
D5F51_21625	COG0444	Belongs to the ABC transporter superfamily
D5F51_21630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_21635	COG0601	transmembrane transport
D5F51_21640	COG0747	negative chemotaxis
D5F51_21645	COG3210	domain, Protein
D5F51_21650	COG2831	hemolysin activation secretion protein
D5F51_21670	COG3851	Histidine kinase
D5F51_21675	COG2197	response regulator
D5F51_21680	COG2194	sulfuric ester hydrolase activity
D5F51_21685	COG1764	response to oxidative stress
D5F51_21700	COG2986	histidine ammonia-lyase
D5F51_21705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D5F51_21710	COG1609	Transcriptional regulator
D5F51_21795	COG0582	viral genome integration into host DNA
D5F51_21805	COG2207	Transcriptional regulator
D5F51_21805	COG1609	Transcriptional regulator
D5F51_21810	COG4214	carbohydrate transport
D5F51_21820	COG4213	ABC transporter substrate-binding protein
D5F51_21825	COG2115	Belongs to the xylose isomerase family
D5F51_21830	COG1070	Carbohydrate kinase
D5F51_21835	COG3121	Chaperone
D5F51_21840	COG1335	isochorismatase
D5F51_21850	COG3274	enterobacterial common antigen metabolic process
D5F51_21860	COG3276	selenocysteine insertion sequence binding
D5F51_21865	COG1921	L-seryl-tRNASec selenium transferase activity
D5F51_21870	COG3058	Necessary for formate dehydrogenase activity
D5F51_21875	COG2864	formate dehydrogenase
D5F51_21880	COG0437	4 iron, 4 sulfur cluster binding
D5F51_21890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5F51_21895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5F51_21900	COG0840	transmembrane signaling receptor activity
D5F51_21905	COG2258	MOSC domain
D5F51_21915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_21925	COG3722	fumarate hydratase activity
D5F51_21930	COG0246	Mannitol dehydrogenase
D5F51_21935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_21935	COG2213	PTS system mannitol-specific
D5F51_21945	COG0751	glycine-tRNA ligase activity
D5F51_21950	COG0752	glycyl-tRNA synthetase alpha subunit
D5F51_21955	COG2818	Glycosylase
D5F51_21960	COG0456	acetyltransferase
D5F51_21985	COG0366	Alpha amylase catalytic
D5F51_21990	COG3977	Valine--pyruvate aminotransferase
D5F51_22015	COG5645	(Lipo)protein
D5F51_22020	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_22035	COG2423	ornithine cyclodeaminase activity
D5F51_22045	COG3188	usher protein
D5F51_22050	COG3121	Chaperone
D5F51_22060	COG3328	transposase activity
D5F51_22065	COG0561	phosphatase activity
D5F51_22070	COG0187	DNA topoisomerase II activity
D5F51_22080	COG0592	DNA-directed DNA polymerase activity
D5F51_22085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5F51_22095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5F51_22100	COG0594	ribonuclease P activity
D5F51_22105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5F51_22110	COG0706	membrane insertase activity
D5F51_22115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5F51_22120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5F51_22135	COG2011	ABC-type metal ion transport system permease component
D5F51_22140	COG0840	transmembrane signaling receptor activity
D5F51_22145	COG0431	NADPH-dependent FMN reductase
D5F51_22165	COG2252	PERMEase
D5F51_22170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_22180	COG0765	amino acid transport
D5F51_22185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_22200	COG0704	Plays a role in the regulation of phosphate uptake
D5F51_22210	COG0581	inorganic phosphate transmembrane transporter activity
D5F51_22215	COG0573	inorganic phosphate transmembrane transporter activity
D5F51_22220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5F51_22235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5F51_22240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5F51_22245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5F51_22250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5F51_22255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5F51_22260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5F51_22265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5F51_22270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5F51_22280	COG0356	it plays a direct role in the translocation of protons across the membrane
D5F51_22285	COG3312	ion transport
D5F51_22290	COG0357	Ribosomal RNA small subunit methyltransferase G
D5F51_22295	COG0445	tRNA wobble uridine modification
D5F51_22305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5F51_22315	COG2373	Large extracellular alpha-helical protein
D5F51_22315	COG1388	LysM domain
D5F51_22315	COG4932	domain protein
D5F51_22415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5F51_22420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5F51_22455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5F51_22485	COG3316	Transposase and inactivated derivatives
D5F51_22500	COG3121	Chaperone
D5F51_22505	COG3188	usher protein
D5F51_22515	COG0789	Transcriptional regulator
D5F51_22550	COG1393	Belongs to the ArsC family