locus-tag class description FFE93_000005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FFE93_000010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FFE93_000020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FFE93_000025 ENOG410667J hydrolase FFE93_000030 ENOG4106JH6 (LipO)protein FFE93_000035 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FFE93_000045 ENOG4108R3E Dna-3-methyladenine glycosylase i FFE93_000050 ENOG4105HNP -acetyltransferase FFE93_000060 ENOG4108ZG0 Ompa motb domain protein FFE93_000080 ENOG4107T9C Alpha amylase catalytic region FFE93_000085 ENOG4105JKW Valine--pyruvate aminotransferase FFE93_000090 ENOG4105D0C transport protein FFE93_000105 ENOG4105R2A (LipO)protein FFE93_000110 ENOG4105D99 atp gtp-binding protein FFE93_000120 ENOG41090BB DNA mismatch endonuclease (vsr) FFE93_000130 ENOG4108SGR YheO domain-containing protein FFE93_000135 ENOG4105C7B Threonine dehydratase FFE93_000145 ENOG4105CTS PTS system mannitol-specific FFE93_000150 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FFE93_000155 ENOG4105E61 Mannitol repressor protein FFE93_000165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FFE93_000170 ENOG4108YYI Protein of unknown function (DUF2810) FFE93_000185 ENOG4108RPX mosc domain containing protein FFE93_000190 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_000200 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FFE93_000205 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FFE93_000215 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FFE93_000220 ENOG4108MG3 formate dehydrogenase FFE93_000230 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FFE93_000235 ENOG4105EM7 Selenocysteine-specific translation elongation factor FFE93_000240 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FFE93_000255 ENOG4105MEV Acyl-transferase FFE93_000270 ENOG4105CMG Carbohydrate kinase FFE93_000275 ENOG4105C93 Xylose Isomerase FFE93_000280 ENOG4105DFW ABC transporter FFE93_000290 ENOG4107RNG ABC transporter FFE93_000295 ENOG4105T16 Transcriptional regulator (AraC family) FFE93_000305 ENOG41066YJ Beta-lactamase FFE93_000310 ENOG4105K89 arsenate reductase FFE93_000335 ENOG4105DSJ YicC domain protein FFE93_000340 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FFE93_000345 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FFE93_000350 ENOG4105CK2 sodium dicarboxylate symporter FFE93_000355 ENOG4105CS0 peptidase FFE93_000360 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FFE93_000365 ENOG4105VSH 4-oxalocrotonate tautomerase FFE93_000370 ENOG4105CMB EAL domain-containing protein FFE93_000375 ENOG41066T0 asmA family FFE93_000380 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) FFE93_000385 ENOG4107H3J ribonuclease FFE93_000395 ENOG4105DC8 reductase FFE93_000400 ENOG4105D6S protein involved in catabolism of external DNA FFE93_000405 ENOG4105DGW oligopeptidase A FFE93_000410 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FFE93_000430 ENOG4105EJC lysr family transcriptional regulator FFE93_000465 ENOG4105CSA Coproporphyrinogen iii oxidase FFE93_000480 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FFE93_000510 ENOG4105F27 Major Facilitator FFE93_000525 ENOG4108M6U Universal stress protein A FFE93_000530 ENOG4108V6B universal stress protein B FFE93_000535 ENOG4105CJ3 phosphate transporter FFE93_000540 ENOG4105CBX hi0933 family FFE93_000570 ENOG4105CW0 outer membrane usher protein FFE93_000585 ENOG4105WCN acetyltransferase FFE93_000590 ENOG4105C2I pirin domain protein FFE93_000595 ENOG4105DIQ Transcriptional regulator FFE93_000600 ENOG4105C6Z Gluconate FFE93_000605 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FFE93_000610 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FFE93_000615 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FFE93_000620 ENOG4108HRK Histidine kinase FFE93_000625 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FFE93_000630 ENOG4108IUM Glycogen debranching enzyme FFE93_000640 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FFE93_000645 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FFE93_000650 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FFE93_000655 ENOG4105E98 transcriptional regulator DeoR family FFE93_000660 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FFE93_000680 ENOG41061ZR Transcriptional regulator FFE93_000685 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FFE93_000690 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FFE93_000695 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FFE93_000700 ENOG4105MJ2 Competence protein FFE93_000705 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FFE93_000710 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) FFE93_000715 ENOG4105CE1 Ferrous iron transport protein b FFE93_000720 ENOG4105XFK Ferrous iron transport protein A FFE93_000725 ENOG4105BZM domain protein FFE93_000735 ENOG4108RRZ Transcription elongation factor GreB FFE93_000740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FFE93_000745 ENOG4105E0F Histidine kinase FFE93_000755 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FFE93_000765 ENOG4105VEJ Heat shock protein FFE93_000770 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FFE93_000775 ENOG4105DQY intracellular growth attenuator FFE93_000780 ENOG4107RK2 ADP-ribose diphosphatase NudE FFE93_000785 ENOG4108JQC penicillin-binding protein 1A FFE93_000810 ENOG4105E4G Type IV pilus FFE93_000815 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FFE93_000835 ENOG4105DJV ribulose-phosphate 3-epimerase FFE93_000845 ENOG4105C31 Tryptophanyl-tRNA synthetase FFE93_000850 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FFE93_000855 ENOG4107V9H nitrite transporter FFE93_000860 ENOG4105WZK nitrite reductase NADPH small subunit FFE93_000865 ENOG4107QZF nitrite reductase NADPH large subunit FFE93_000870 ENOG4105DZC cytosine deaminase FFE93_000875 ENOG4106DTQ Protein TsgA homolog FFE93_000890 ENOG41060NJ transcriptional regulator FFE93_000895 ENOG4105F8D glycoside hydrolase family 4 FFE93_000900 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FFE93_000905 ENOG4105D7A ATP-binding protein FFE93_000915 ENOG4105C8Y Acetylornithine aminotransferase FFE93_000920 ENOG410613R integral membrane protein, YccS YhfK family FFE93_000930 ENOG4108UKZ OsmC family FFE93_000935 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FFE93_000940 ENOG4105YP7 UPF0270 protein FFE93_000945 ENOG4105DNZ Alpha Beta Hydrolase FFE93_000955 ENOG4105JAB phenazine biosynthesis protein, phzf family FFE93_000960 ENOG4106FTQ Taurine ABC transporter, periplasmic FFE93_000970 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FFE93_000975 ENOG4105E2B Taurine dioxygenase FFE93_000980 ENOG4107QRS glycosyltransferase group 2 family protein FFE93_000985 ENOG4105C5H ABC transporter FFE93_000990 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FFE93_001000 ENOG4105VKU nucleicacid-binding protein FFE93_001005 ENOG4108YZY peptidylprolyl cis-trans isomerase FFE93_001015 ENOG4108V1T peptidylprolyl cis-trans isomerase FFE93_001020 ENOG4105WWK YheO domain protein FFE93_001025 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FFE93_001035 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FFE93_001045 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FFE93_001055 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FFE93_001080 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FFE93_001090 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FFE93_001095 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FFE93_001100 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FFE93_001105 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FFE93_001110 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FFE93_001115 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FFE93_001120 ENOG41083MP 50s ribosomal protein l29 FFE93_001125 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FFE93_001145 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FFE93_001155 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FFE93_001160 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FFE93_001165 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FFE93_001170 ENOG4105VPB 50S ribosomal protein L30 FFE93_001175 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FFE93_001180 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FFE93_001185 ENOG41067V7 50S ribosomal protein L36 FFE93_001190 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FFE93_001195 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FFE93_001200 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FFE93_001205 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FFE93_001210 ENOG4108ZT0 50S ribosomal protein l17 FFE93_001215 ENOG4105VTS DnaJ-like, subfamily C FFE93_001220 ENOG4105W1Y Transcriptional regulator FFE93_001225 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FFE93_001230 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FFE93_001235 ENOG4105C1A potassium transporter peripheral membrane FFE93_001240 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FFE93_001245 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FFE93_001250 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FFE93_001255 ENOG4105C79 DNA protecting protein DprA FFE93_001265 ENOG4108WI1 Dna topoisomerase FFE93_001270 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FFE93_001275 ENOG4105E2X shikimate dehydrogenase FFE93_001280 ENOG4108Z0R Transferase FFE93_001320 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FFE93_001325 ENOG4105CS9 pantothenic acid kinase FFE93_001370 ENOG4105PM1 preprotein translocase subunit SecE FFE93_001375 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FFE93_001380 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FFE93_001385 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FFE93_001390 ENOG4108VZM 50s ribosomal protein L10 FFE93_001395 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FFE93_001400 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FFE93_001405 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FFE93_001410 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FFE93_001420 ENOG4105D41 biosynthesis protein thiH FFE93_001425 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FFE93_001430 ENOG4105WHD thiamine biosynthesis protein ThiS FFE93_001435 ENOG4105D06 uba thif-type nad fad binding protein FFE93_001445 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FFE93_001450 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor FFE93_001455 ENOG4105E09 nadh pyrophosphatase FFE93_001465 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FFE93_001470 ENOG4105R2J Conserved Protein FFE93_001480 ENOG4108T8B Protein of unknown function (DUF1481) FFE93_001485 ENOG4105C12 Phosphoribosylglycinamide synthetase FFE93_001535 ENOG4105CVG Homoserine O-transsuccinylase FFE93_001540 ENOG4107QP3 malate synthase g FFE93_001550 ENOG4108I9X Isocitrate lyase FFE93_001555 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FFE93_001560 ENOG41069M3 Transcriptional regulator FFE93_001565 ENOG4105C3R Methionine synthase FFE93_001580 ENOG4105CFH Aspartokinase FFE93_001585 ENOG4107QP8 phosphohexose isomerase FFE93_001590 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FFE93_001595 ENOG4105EG2 ABC transporter, permease FFE93_001600 ENOG4105D56 permease protein FFE93_001605 ENOG4107FKK extracellular solute-binding protein family 1 FFE93_001625 ENOG4107W52 maltose operon periplasmic protein FFE93_001630 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FFE93_001640 ENOG4105E55 glycerol-3-phosphate acyltransferase FFE93_001645 ENOG41080IJ Diacylglycerol kinase FFE93_001650 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FFE93_001655 ENOG4105VDW Csbd family FFE93_001660 ENOG4105MYN Zinc uptake regulation protein FFE93_001665 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FFE93_001670 ENOG4105P4Z Phage shock protein G FFE93_001680 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FFE93_001685 ENOG4105CDU Replicative dna helicase FFE93_001690 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FFE93_001695 ENOG4105CGF Aromatic amino acid aminotransferase FFE93_001700 ENOG4105MSB protein, conserved in bacteria FFE93_001705 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FFE93_001730 ENOG4105C7N Xanthine uracil vitamin C permease FFE93_001735 ENOG4105EEQ Na H antiporter FFE93_001750 ENOG4105CDA abc transporter atp-binding protein FFE93_001755 ENOG4105DRP amino acid AbC transporter FFE93_001760 ENOG4105EZ7 amino acid ABC transporter FFE93_001770 ENOG4105D1S lipid A biosynthesis FFE93_001780 ENOG4105C2J ABC transporter FFE93_001785 ENOG4105CNN ABC, transporter FFE93_001795 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FFE93_001800 ENOG4105C2X Arabinose 5-phosphate isomerase FFE93_001805 ENOG4107QPK )-transporter FFE93_001810 ENOG4105VEQ Cold shock protein FFE93_001815 ENOG4105VEQ Cold shock protein FFE93_001820 ENOG4108XTF Outer Membrane Lipoprotein FFE93_001825 ENOG4105BZU Histidine kinase FFE93_001830 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FFE93_001835 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FFE93_001840 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FFE93_001845 ENOG4108IA2 Sodium pantothenate symporter FFE93_001850 ENOG4105RG0 Membrane FFE93_001855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FFE93_001860 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FFE93_001865 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FFE93_001870 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FFE93_001880 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FFE93_001885 ENOG41062P1 Diguanylate cyclase phosphodiesterase FFE93_001890 ENOG4105DFF Rod shape-determining protein mreb FFE93_001895 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FFE93_001900 ENOG4105VQ7 Rod shape-determining protein MreD FFE93_001910 ENOG4105C03 ribonuclease FFE93_001915 ENOG4105QD6 exported protein FFE93_001925 ENOG4105D1U peptidase U62 modulator of DNA gyrase FFE93_001930 ENOG4105CR8 Transcriptional regulator FFE93_001935 ENOG4105ZQC membrane protein AaeX FFE93_001940 ENOG4105Y49 secretion protein, HlyD family FFE93_001945 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) FFE93_001950 ENOG4105C26 Dehydrogenase FFE93_001960 ENOG4105UNR (Barnase) inhibitor FFE93_001965 ENOG4105N42 UPF0307 protein FFE93_001970 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FFE93_002005 ENOG4105DFE Dna adenine methylase FFE93_002010 ENOG4105VZ1 Replication Protein FFE93_002040 ENOG4105ED4 portal protein FFE93_002195 ENOG4105ZTC transcriptional activator, Ogr delta FFE93_002200 ENOG4105EKQ RNA-directed DNA polymerase FFE93_002210 ENOG4105CMS peptidase U62, modulator of DNA gyrase FFE93_002215 ENOG4108XVM Cytochrome b(562) FFE93_002220 ENOG4105NXH GreA GreB family elongation factor FFE93_002250 ENOG41069H0 dihydroorotase EC 3.5.2.3 FFE93_002265 ENOG4105EMD TRANSCRIPTIONal FFE93_002270 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FFE93_002275 ENOG4105D4X repressor FFE93_002280 ENOG4105C5Y PTS System FFE93_002285 ENOG4105CG3 alpha amylase, catalytic region FFE93_002310 ENOG4105KME endoribonuclease L-psp FFE93_002315 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FFE93_002320 ENOG4105CXT aspartate transcarbamylase FFE93_002325 ENOG41080Z8 PHOSPHOCARRIER protein FFE93_002335 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FFE93_002340 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FFE93_002345 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FFE93_002350 ENOG4108IUZ ABC transporter FFE93_002355 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FFE93_002360 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FFE93_002365 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FFE93_002370 ENOG4105C2X Arabinose 5-phosphate isomerase FFE93_002375 ENOG4105FEU K -dependent Na -Ca exchanger FFE93_002380 ENOG4105DHJ ABC, transporter FFE93_002385 ENOG4105CY3 ABC transporter, permease FFE93_002390 ENOG4107PE3 Mammalian cell entry related domain protein FFE93_002395 ENOG4105E3I toluene tolerance FFE93_002400 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FFE93_002405 ENOG4105VFK BolA family FFE93_002415 ENOG4105C0H protease FFE93_002420 ENOG4105C0H protease FFE93_002425 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FFE93_002430 ENOG4105D6Z AFG1 family ATPase FFE93_002435 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FFE93_002440 ENOG4108UJD 30S ribosomal protein S9 FFE93_002450 ENOG4107MKT Stringent starvation protein a FFE93_002455 ENOG4105KB2 stringent starvation protein b FFE93_002470 ENOG4105BZ8 glutamate synthase FFE93_002475 ENOG4105CBC glutamate synthase FFE93_002480 ENOG4105N5T Radical SAM Protein FFE93_002485 ENOG4105BZU Histidine kinase FFE93_002495 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FFE93_002500 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FFE93_002505 ENOG4105W4M Transport-associated protein FFE93_002510 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FFE93_002515 ENOG41082RQ UPF0102 protein FFE93_002525 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FFE93_002565 ENOG4105DQ4 alcohol dehydrogenase FFE93_002570 ENOG4108CNN domain protein FFE93_002575 ENOG4105CWB LysR family transcriptional Regulator FFE93_002580 ENOG4105CHF Glutathione S-transferase FFE93_002585 ENOG4108VBZ doxx family FFE93_002590 ENOG4105YJD FFE93_002595 ENOG41090KG Inner membrane protein YqjE FFE93_002600 ENOG4105NE1 Conserved Protein FFE93_002615 ENOG4106W5V Membrane FFE93_002630 ENOG4105DPW Major facilitator superfamily MFS_1 FFE93_002635 ENOG4105D2H Uronic isomerase FFE93_002640 ENOG4107QZW Altronate oxidoreductase FFE93_002645 ENOG4105CTX dehydratase FFE93_002650 ENOG4105P66 Membrane FFE93_002655 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FFE93_002660 ENOG4105DU1 integral membrane protein, terc FFE93_002665 ENOG4105EE0 oxidoreductase FFE93_002670 ENOG4108VKG metal-dependent hydrolase FFE93_002675 ENOG4106AS2 Outer membrane autotransporter FFE93_002680 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FFE93_002690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FFE93_002695 ENOG4108YK4 Acid-resistance membrane protein FFE93_002730 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FFE93_002735 ENOG4108ZC9 flagellar basal-body rod protein flgc FFE93_002740 ENOG4105W00 Flagellar hook capping protein FFE93_002745 ENOG4105BZE flagellar hook protein, FlgE FFE93_002750 ENOG4108KPB Flagellar basal-body rod protein FlgF FFE93_002755 ENOG4105CGA flagellar basal-body rod protein FlgG FFE93_002770 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FFE93_002775 ENOG4105E1Q flagellar hook-associated protein FFE93_002780 ENOG4105DTJ flagellar hook-associated protein FFE93_002785 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_002790 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FFE93_002800 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FFE93_002805 ENOG4107RD7 Flagellar Motor Protein, MotA FFE93_002810 ENOG4105ER2 Ompa motb domain protein FFE93_002815 ENOG4105CBS Chea signal transduction histidine kinase FFE93_002820 ENOG4108V3W Chemotaxis protein, CheW FFE93_002825 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_002835 ENOG4105I03 Flagellin FFE93_002840 ENOG4105DTS flagellar hook-associated FFE93_002845 ENOG4105MQ3 flagellar protein FliS FFE93_002850 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) FFE93_002855 ENOG4105W13 flagellar protein FFE93_002860 ENOG4105D7B Flagellar biosynthesis protein flha FFE93_002865 ENOG4105D00 flagellar biosynthetic protein flhB FFE93_002875 ENOG4108VYJ response regulator receiver protein FFE93_002880 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FFE93_002885 ENOG4105BZU Histidine kinase FFE93_002890 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FFE93_002895 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FFE93_002900 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FFE93_002910 ENOG4108JIR Flagellum-specific ATP synthase FFE93_002915 ENOG4105GSA Flagellar export protein flij FFE93_002920 ENOG4105WF4 Flagellar hook-length control protein FFE93_002925 ENOG4107ZI8 flagellar basal body-associated protein flil FFE93_002930 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FFE93_002935 ENOG4105DD5 Flagellar motor switch protein FFE93_002940 ENOG4105K0P flagellar biosynthesis protein FFE93_002945 ENOG4105CN7 Flagellar biosynthetic protein FliP FFE93_002950 ENOG4105VS8 Flagellar biosynthetic protein fliq FFE93_002955 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FFE93_002960 ENOG4108WQH regulatoR FFE93_002965 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_002975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FFE93_002980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FFE93_002985 ENOG4105VCC 30S ribosomal protein S21 FFE93_002990 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FFE93_002995 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FFE93_003000 ENOG4107ZVW dihydroneopterin aldolase FFE93_003005 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FFE93_003010 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FFE93_003015 ENOG4106MWK domain protein FFE93_003020 ENOG4105I7R Adenylate cyclase FFE93_003025 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FFE93_003030 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FFE93_003035 ENOG4105DVH amino acid FFE93_003040 ENOG4105W0Z cytoplasmic protein FFE93_003045 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FFE93_003050 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FFE93_003055 ENOG4106032 Glutathionylspermidine synthase FFE93_003060 ENOG4105F1G UPF0441 protein FFE93_003065 ENOG4105DFG type I secretion outer membrane protein FFE93_003070 ENOG41087AY ADP-Ribose pyrophosphatase FFE93_003075 ENOG4108SX3 cytoplasmic protein FFE93_003080 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FFE93_003085 ENOG4105IPS esterase FFE93_003090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FFE93_003095 ENOG4105HEI LysR family (Transcriptional regulator FFE93_003100 ENOG4105VRH Antibiotic biosynthesis monooxygenase FFE93_003105 ENOG4105NF4 modulator of drug activity FFE93_003115 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FFE93_003120 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FFE93_003125 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FFE93_003135 ENOG4105CV8 reductase FFE93_003140 ENOG4108I6A alcohol dehydrogenase FFE93_003145 ENOG4105CF7 AraC family transcriptional regulator FFE93_003150 ENOG4108K81 inner membrane protein YghB FFE93_003155 ENOG4105C28 cystathionine FFE93_003160 ENOG4105CWK Biopolymer transport protein, ExbB FFE93_003165 ENOG4108ZZF transport protein (ExbD) FFE93_003240 ENOG4108IJF Heavy metal efflux pump, CzcA FFE93_003245 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FFE93_003270 ENOG4105E0A ABC, transporter FFE93_003275 ENOG4105TVJ transport system, permease FFE93_003280 ENOG4105DQ5 transport system permease protein FFE93_003285 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FFE93_003290 ENOG4108SF5 RNA Polymerase FFE93_003295 ENOG4108S3W Anti-feci sigma factor, fecr FFE93_003300 ENOG4105PE1 Receptor FFE93_003305 ENOG4107RAN Peptidase, M16 FFE93_003310 ENOG4105CQ0 ABC transporter FFE93_003315 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_003335 ENOG4108XTF Outer Membrane Lipoprotein FFE93_003340 ENOG4105E3S small subunit FFE93_003345 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FFE93_003350 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit FFE93_003355 ENOG4105DPX Hydrogenase, large subunit FFE93_003360 ENOG4108USZ hydrogenase FFE93_003365 ENOG4108WGS hydrogenase 2-specific chaperone FFE93_003370 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FFE93_003375 ENOG4107RSS Hydrogenase accessory protein HypB FFE93_003380 ENOG41082MF Hydrogenase assembly chaperone hypC hupF FFE93_003385 ENOG4105CQS hydrogenase expression formation protein HypD FFE93_003390 ENOG4105C45 hydrogenase expression formation protein (HypE) FFE93_003395 ENOG4105C8H hydrogenase maturation protein Hypf FFE93_003410 ENOG4105C1P efflux transporter, rnd family, mfp subunit FFE93_003420 ENOG4105CSH Transporter FFE93_003430 ENOG4105EAM Na Pi-cotransporter FFE93_003440 ENOG4105ETE Transcriptional regulator (LacI family FFE93_003460 ENOG4105CM4 permease protein FFE93_003465 ENOG4108IPW abc transporter atp-binding protein FFE93_003470 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FFE93_003480 ENOG4105D5K Hemolysin activator protein FFE93_003560 ENOG4105J12 Multidrug resistance protein mdtN FFE93_003565 ENOG4108MI0 Resistance protein FFE93_003575 ENOG4107B2H carbonic anhydrase FFE93_003615 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FFE93_003665 ENOG4105ER2 Ompa motb domain protein FFE93_003700 ENOG4105CS6 Rhs element vgr protein FFE93_003725 ENOG4105VJY transcriptional regulator FFE93_003745 ENOG4105TNG K13735 adhesin invasin FFE93_003770 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FFE93_003775 ENOG4108W9T type 1 fimbriae regulatory protein FFE93_003795 ENOG4106PG1 outer membrane usher protein FFE93_003800 ENOG4106P2F Pfam:Pili_assembly_C FFE93_003810 ENOG4105NEV Fimbrial FFE93_003825 ENOG4105HEI LysR family (Transcriptional regulator FFE93_003880 ENOG4105CXN decarboxylase FFE93_003890 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FFE93_003900 ENOG4105CEN a g-specific adenine glycosylase FFE93_003905 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FFE93_003910 ENOG41090ED Protein with unknown function (DUF469) FFE93_003920 ENOG4105ZTC transcriptional activator, Ogr delta FFE93_003965 ENOG4108C33 Resolvase FFE93_003970 ENOG4105UZW Tail fiber assembly protein FFE93_004005 ENOG4105MZU cell filamentation protein FFE93_004075 ENOG4105ED4 portal protein FFE93_004100 ENOG4105DFE Dna adenine methylase FFE93_004140 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FFE93_004145 ENOG4105CSV Glutaminase FFE93_004150 ENOG4105K33 Periplasmic Protein FFE93_004155 ENOG4105CSA Coproporphyrinogen iii oxidase FFE93_004160 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FFE93_004165 ENOG4105VZ9 UPF0235 protein FFE93_004170 ENOG4108VIA integral membrane protein FFE93_004175 ENOG4105II7 pyrroline-5-carboxylate reductase FFE93_004180 ENOG4105DFA alanine racemase domain protein FFE93_004185 ENOG4105CZX twitching motility protein FFE93_004195 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) FFE93_004200 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FFE93_004205 ENOG4108UJU UPF0301 protein FFE93_004210 ENOG4105D7Z glutathione synthase FFE93_004215 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FFE93_004220 ENOG4105RWS endonuclease I FFE93_004225 ENOG4105GPY SprT protein FFE93_004235 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FFE93_004240 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FFE93_004250 ENOG4108K0D peptidase, M48 FFE93_004255 ENOG4105CV1 Transketolase (EC 2.2.1.1) FFE93_004265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FFE93_004270 ENOG4105BZA Phosphoglycerate kinase FFE93_004275 ENOG4105D2N Aldolase FFE93_004280 ENOG4105EKQ RNA-directed DNA polymerase FFE93_004285 ENOG4105D64 Mechanosensitive ion channel FFE93_004290 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FFE93_004295 ENOG4105MPN Membrane FFE93_004300 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FFE93_004305 ENOG4105E66 phosphoriboisomerase A FFE93_004310 ENOG4108JQ1 Dehydrogenase FFE93_004315 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FFE93_004325 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FFE93_004330 ENOG4105E07 UPF0149 protein FFE93_004335 ENOG4107RAQ aminopeptidase FFE93_004340 ENOG4105D0A hydroxylase FFE93_004345 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FFE93_004350 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FFE93_004360 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FFE93_004365 ENOG4108UT2 hemolysin iii FFE93_004370 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FFE93_004375 ENOG4105Y75 tpr repeat protein FFE93_004385 ENOG4105E3W Two component transcriptional regulator (Winged helix family FFE93_004390 ENOG4105EB3 Histidine kinase FFE93_004395 ENOG4105CT7 inner membrane cred family protein FFE93_004400 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FFE93_004405 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FFE93_004410 ENOG4105T95 Thiol disulfide interChange protein FFE93_004415 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FFE93_004425 ENOG4105CRK lysyL-tRNA synthetase FFE93_004440 ENOG41090SZ ABC-2 type transporter FFE93_004455 ENOG4107VDP teichoic acid biosynthesis FFE93_004460 ENOG41084CK capsule polysaccharide FFE93_004465 ENOG4105E12 capsule polysaccharide FFE93_004470 ENOG4107V1M polysaccharide export protein FFE93_004475 ENOG4105ECX polysaccharide export FFE93_004480 ENOG4105BZU Histidine kinase FFE93_004485 ENOG4105F7P transcriptional regulator AsnC family FFE93_004500 ENOG4105DPW Major facilitator superfamily MFS_1 FFE93_004510 ENOG4105DVC DnaJ domain protein FFE93_004520 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FFE93_004525 ENOG4105KVH Transcriptional regulator FFE93_004545 ENOG4107QHF type ii secretion system protein e FFE93_004550 ENOG4105D7Q type ii secretion system FFE93_004615 ENOG4105EJC lysr family transcriptional regulator FFE93_004620 ENOG4105F27 Major Facilitator FFE93_004625 ENOG4105RQF LysR family Transcriptional regulator FFE93_004630 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FFE93_004635 ENOG41060NJ transcriptional regulator FFE93_004645 ENOG4105CEY Amp-dependent synthetase and ligase FFE93_004650 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FFE93_004660 ENOG4105CPC Aldo Keto reductase FFE93_004665 ENOG4105EE5 Membrane protein terC FFE93_004680 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FFE93_004685 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FFE93_004690 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FFE93_004720 ENOG4105DSY exodeoxyribonuclease V, gamma FFE93_004725 ENOG4107QXK peptidase FFE93_004730 ENOG4107QKA exodeoxyribonuclease V beta FFE93_004735 ENOG4107QYX exodeoxyribonuclease v alpha FFE93_004740 ENOG4107QZM n-acetylglutamate synthase FFE93_004745 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FFE93_004765 ENOG4105CA3 membrane-bound lytic murein transglycosylase FFE93_004770 ENOG4105CUZ uba thif-type nad fad binding protein FFE93_004775 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FFE93_004780 ENOG4105C9B Cysteine desulfurase FFE93_004785 ENOG4105M5B (LipO)protein FFE93_004790 ENOG4105ETT transcriptional Regulator, LysR family FFE93_004795 ENOG4105M08 Membrane FFE93_004800 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FFE93_004810 ENOG4105EWT decarboxylase family FFE93_004815 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FFE93_004820 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FFE93_004825 ENOG4105WP7 tRNA pseudouridine synthase C FFE93_004830 ENOG4105DR9 pseudouridine synthase FFE93_004835 ENOG4105QDK Flavodoxin FFE93_004845 ENOG4108T8E UPF0325 protein FFE93_004850 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FFE93_004855 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FFE93_004860 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FFE93_004865 ENOG4105CE9 30S ribosomal protein S2 FFE93_004870 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FFE93_004875 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FFE93_004880 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FFE93_004885 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FFE93_004890 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FFE93_004895 ENOG4105KNE Phosphatidate cytidylyltransferase FFE93_004900 ENOG4105DZP Membrane-associated zinc metalloprotease FFE93_004910 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FFE93_004925 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FFE93_004930 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FFE93_004935 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FFE93_004940 ENOG4105C0B DNA polymerase III (alpha subunit) FFE93_004945 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FFE93_004950 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FFE93_004955 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FFE93_004965 ENOG4105M1T rho-binding antiterminator FFE93_004975 ENOG4108VWS Yaeq family FFE93_004980 ENOG4108YZN class I peptide chain release factor FFE93_004985 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FFE93_004995 ENOG4108R96 Methyltransferase, YaeB family FFE93_005000 ENOG4108R8X outer membrane lipoprotein FFE93_005005 ENOG4105D01 (LipO)protein FFE93_005010 ENOG4108UMI ABC transporter, permease FFE93_005020 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FFE93_005050 ENOG4105CV8 reductase FFE93_005060 ENOG4107NA1 Endonuclease Exonuclease phosphatase FFE93_005065 ENOG4105E9H Lytic Murein transglycosylase FFE93_005070 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FFE93_005075 ENOG4105D1A Methyltransferase FFE93_005080 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FFE93_005085 ENOG4108JDX DNA polymerase iii, epsilon subunit FFE93_005095 ENOG4105GIJ Glycine betaine FFE93_005100 ENOG4108HQS Glycine betaine FFE93_005105 ENOG4108IJ7 Glycine betaine FFE93_005110 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FFE93_005120 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FFE93_005125 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FFE93_005130 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FFE93_005140 ENOG4105NE1 Conserved Protein FFE93_005150 ENOG4108WMJ Protein of unknown function (DUF2002) FFE93_005155 ENOG4108SAJ Protein of unknown function (DUF1198) FFE93_005165 ENOG4105VEQ Cold shock protein FFE93_005180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FFE93_005190 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FFE93_005205 ENOG4105KI2 Urea amidohydrolase subunit beta FFE93_005210 ENOG4105CQM Urea amidohydrolase subunit alpha FFE93_005225 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FFE93_005245 ENOG4105XXV Acid-resistance protein FFE93_005250 ENOG4107SVH Potassium channel protein FFE93_005255 ENOG41086WQ Protein CrcB homolog FFE93_005265 ENOG4105D8V Glucose sorbosone dehydrogenase FFE93_005270 ENOG4105VZJ PTS System FFE93_005275 ENOG4105CK1 PTS System FFE93_005280 ENOG4105CS2 ec 3.2.1.21 FFE93_005285 ENOG4105VCP PTS System FFE93_005290 ENOG4105EZV Transcriptional regulator FFE93_005295 ENOG410901P UPF0249 protein FFE93_005305 ENOG4105EKQ RNA-directed DNA polymerase FFE93_005360 ENOG4105ZTC transcriptional activator, Ogr delta FFE93_005390 ENOG4105DFP Integrase FFE93_005400 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FFE93_005405 ENOG4108Z1B Cyclase dehydrase FFE93_005415 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FFE93_005420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FFE93_005425 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FFE93_005430 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FFE93_005435 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FFE93_005440 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FFE93_005445 ENOG4105C1J atp-dependent rna helicase FFE93_005450 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FFE93_005455 ENOG4108IYU L-aspartate oxidase FFE93_005465 ENOG41069PW sigma-e factor negative regulatory protein FFE93_005475 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FFE93_005485 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FFE93_005490 ENOG4105C3F Signal peptidase i FFE93_005500 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FFE93_005505 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FFE93_005510 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FFE93_005520 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FFE93_005525 ENOG4106G6Q Transcriptional regulator FFE93_005540 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FFE93_005550 ENOG4108Z6B deaminase FFE93_005555 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FFE93_005570 ENOG4107WP9 Histidine kinase FFE93_005575 ENOG4108SKK alpha helix protein FFE93_005580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FFE93_005585 ENOG4105C4K Nad synthetase FFE93_005590 ENOG4108YZA Nitrogen regulatory protein pii FFE93_005595 ENOG4106M0N transport system permease protein FFE93_005600 ENOG4105MUZ Protein of unknown function DUF2620 FFE93_005605 ENOG41080QX K07048 phosphotriesterase-related protein FFE93_005610 ENOG4108626 Racemase FFE93_005615 ENOG4105RMW regulation of transcription, DNA-dependent FFE93_005620 ENOG4108M21 FFE93_005625 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FFE93_005635 ENOG4105D8G Major Facilitator superfamily FFE93_005640 ENOG4108MN2 Stationary phase inducible protein CsiE FFE93_005645 ENOG41065CD Exported protein FFE93_005650 ENOG4105D7X high-affinity nickel-transporter FFE93_005660 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FFE93_005670 ENOG4105C3J Cysteine desulfurase FFE93_005675 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FFE93_005690 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FFE93_005695 ENOG4108ZIT Ferredoxin, 2FE-2S FFE93_005700 ENOG4105WVQ Fe-S assembly protein IscX FFE93_005710 ENOG4105YYA enhanced serine sensitivity protein SseB FFE93_005715 ENOG4108MGN ATP-binding component of a transport system FFE93_005720 ENOG4105DN3 alpha-2-macroglobulin domain protein FFE93_005725 ENOG4108JQB penicillin-binding protein 1C FFE93_005765 ENOG4105N21 Membrane FFE93_005770 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FFE93_005775 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FFE93_005785 ENOG4105VPD cellular component movement FFE93_005790 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FFE93_005795 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FFE93_005800 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FFE93_005810 ENOG4105DWF phosphomethylpyrimidine kinase FFE93_005820 ENOG4108ZGU inhibitor of vertebrate lysozyme FFE93_005825 ENOG4105C2X Arabinose 5-phosphate isomerase FFE93_005830 ENOG410804X Transcriptional regulator FFE93_005835 ENOG4105J92 DNA-binding transcriptional activator GutM FFE93_005840 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FFE93_005845 ENOG4105VI0 Pts system, glucitol sorbitol-specific FFE93_005850 ENOG4105DZY Pts system, glucitol sorbitol-specific FFE93_005855 ENOG410787A Pts system, glucitol sorbitol-specific FFE93_005860 ENOG4107TE5 Lipid kinase FFE93_005865 ENOG4105CFP Peptidase U32 FFE93_005870 ENOG4105KWI UPF0339 protein FFE93_005875 ENOG4105E3W Two component transcriptional regulator (Winged helix family FFE93_005880 ENOG4105EB3 Histidine kinase FFE93_005885 ENOG4105BZS acriflavin resistance protein FFE93_005895 ENOG4105ENT Efflux transporter rnd family, mfp subunit FFE93_005900 ENOG4105R8A Heat shock protein FFE93_005905 ENOG4105BZU Histidine kinase FFE93_005910 ENOG4105CJW magnesium transporter FFE93_005920 ENOG4105C9X ppx gppa phosphatase FFE93_005925 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FFE93_005930 ENOG4105C8U phosphate abc transporter FFE93_005935 ENOG4105E2Z phosphate ABC transporter (Permease FFE93_005945 ENOG4108C80 FliB family FFE93_005950 ENOG4108C80 FliB family FFE93_005955 ENOG4108MK9 spermidine N(1)-acetyltransferase FFE93_005960 ENOG4108V3E phosphoribosylglycinamide formyltransferase FFE93_005975 ENOG4105C2W permease FFE93_005980 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FFE93_005985 ENOG4105K89 arsenate reductase FFE93_005990 ENOG4105ERG peptidase m48, ste24p FFE93_005995 ENOG4105C02 permease FFE93_006000 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FFE93_006005 ENOG4105RH4 Glycine cleavage system transcriptional repressor FFE93_006010 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FFE93_006015 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FFE93_006020 ENOG4105C8V SAICAR synthetase FFE93_006025 ENOG4105CGZ zinc metallopeptidase FFE93_006030 ENOG4108VMM UPF0756 membrane protein FFE93_006035 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FFE93_006040 ENOG4106KED esterase YpfH FFE93_006045 ENOG4105XYK UPF0370 protein FFE93_006055 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FFE93_006060 ENOG4105KUZ arsenate reductase FFE93_006075 ENOG4107Z33 ABC transporter, permease FFE93_006080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FFE93_006090 ENOG4105BZS acriflavin resistance protein FFE93_006100 ENOG4105WH1 Two component transcriptional regulator luxr family FFE93_006105 ENOG4108ZNS ferredoxin-type protein NapF FFE93_006110 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase FFE93_006115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FFE93_006120 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) FFE93_006125 ENOG4105CUW cytochrome C-TYPE protein FFE93_006145 ENOG4105C6K Malic enzyme FFE93_006150 ENOG4108UPT UPF0178 protein FFE93_006155 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FFE93_006160 ENOG4108R6G acetyltransferase FFE93_006170 ENOG4105H4F exported protein FFE93_006175 ENOG4105E7K (LipO)protein FFE93_006180 ENOG4105EZR dyp-type peroxidase family protein FFE93_006200 ENOG4108R66 Conserved Protein FFE93_006205 ENOG4105QEK Transcriptional regulator FFE93_006215 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FFE93_006220 ENOG4108I5D sulfate abc transporter FFE93_006225 ENOG4105ECW sulfate abc transporter FFE93_006235 ENOG4105C6T cysteine synthase FFE93_006245 ENOG4105DJY efflux transporter, rnd family, mfp subunit FFE93_006250 ENOG4105E3W Two component transcriptional regulator (Winged helix family FFE93_006255 ENOG4105E0F Histidine kinase FFE93_006260 ENOG4105C5Y PTS System FFE93_006270 ENOG4105KZ7 phosphocarrier protein hpr FFE93_006275 ENOG4105C6T cysteine synthase FFE93_006330 ENOG4105EXN Sulfate transport protein CysZ FFE93_006340 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FFE93_006345 ENOG4105VRT cytoplasmic protein FFE93_006375 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FFE93_006405 ENOG4105D9N nucleoside FFE93_006410 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FFE93_006420 ENOG4105CPC Aldo Keto reductase FFE93_006425 ENOG4105C5Q Transcriptional regulator FFE93_006435 ENOG4105CHC glucokinase (EC 2.7.1.2) FFE93_006440 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system FFE93_006450 ENOG4105FCD Major Facilitator FFE93_006455 ENOG4105DY9 regulatoR FFE93_006460 ENOG4108HRK Histidine kinase FFE93_006465 ENOG41072TH Protein of unknown function (DUF1479) FFE93_006475 ENOG4105CHM Aminotransferase FFE93_006480 ENOG4108VKM cytochrome b561 FFE93_006490 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin FFE93_006495 ENOG4106B0W Curli production assembly transport component CsgG FFE93_006505 ENOG4107Y60 (LipO)protein FFE93_006515 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FFE93_006530 ENOG4105CVE Lytic murein transglycosylase FFE93_006535 ENOG4105CUB amino acid FFE93_006560 ENOG4105DHJ ABC, transporter FFE93_006575 ENOG4105DS1 cytochrome b561 FFE93_006580 ENOG4108YYC ycei family FFE93_006585 ENOG4105DDV Transcriptional regulator (LacI family FFE93_006590 ENOG4105C5Y PTS System FFE93_006595 ENOG4105CS2 ec 3.2.1.21 FFE93_006605 ENOG4105NTW Transcriptional regulator FFE93_006610 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FFE93_006625 ENOG4105S64 Formate nitrite transporter FFE93_006635 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FFE93_006640 ENOG41060IM Heme exporter protein FFE93_006645 ENOG4105X3C heme exporter protein FFE93_006650 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FFE93_006655 ENOG4105DA4 cytochrome c-type biogenesis protein FFE93_006660 ENOG4107QX9 Thiol disulfide interChange protein FFE93_006665 ENOG4105KWW Biogenesis protein FFE93_006670 ENOG4105KWW Biogenesis protein FFE93_006675 ENOG410903C (LipO)protein FFE93_006680 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FFE93_006685 ENOG4105KZW UPF0381 protein FFE93_006690 ENOG4105CHU acetyl-coa acetyltransferase FFE93_006695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FFE93_006700 ENOG4108BY2 phosphohistidine phosphatase FFE93_006710 ENOG4108DG9 Smr protein MutS2 FFE93_006715 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FFE93_006725 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) FFE93_006730 ENOG4105EJ9 Membrane FFE93_006735 ENOG4108BPE -transporting atpase FFE93_006740 ENOG4105MH2 YfcL protein FFE93_006745 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FFE93_006750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FFE93_006755 ENOG4105BZU Histidine kinase FFE93_006765 ENOG4106WZ1 flagella biosynthesis regulator FFE93_006785 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FFE93_006790 ENOG410631K Membrane FFE93_006815 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FFE93_006825 ENOG4105DQR SNARE associated Golgi FFE93_006835 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FFE93_006840 ENOG4108S3P Sporulation domain protein FFE93_006845 ENOG4105E96 Colicin v production protein FFE93_006850 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FFE93_006855 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FFE93_006860 ENOG4105E89 ABC transporter FFE93_006865 ENOG4105DSP amino acid AbC transporter FFE93_006870 ENOG4106YG3 ABC transporter FFE93_006875 ENOG4108JEH abc transporter atp-binding protein FFE93_006885 ENOG4105ECP epimerase FFE93_006895 ENOG4108RE9 Phosphodiesterase FFE93_006900 ENOG4105PTV Nudix Hydrolase FFE93_006905 ENOG4108K4B hydrolase FFE93_006910 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FFE93_006920 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FFE93_006925 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FFE93_006930 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FFE93_006935 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FFE93_006945 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FFE93_006950 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FFE93_006955 ENOG4105CHW UPF0052 protein FFE93_006960 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FFE93_006965 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FFE93_006970 ENOG4105M00 molybdopterin converting factor, subunit 1 FFE93_006975 ENOG4108ZAF Molybdopterin FFE93_006980 ENOG4105HFZ Membrane FFE93_006985 ENOG4107QWP ABC-2 type transporter FFE93_006990 ENOG4107QWP ABC-2 type transporter FFE93_006995 ENOG4105CJ1 ABC, transporter FFE93_007000 ENOG4105D0S secretion protein (HlyD FFE93_007005 ENOG4107MVR Transcriptional regulator FFE93_007010 ENOG4105C1J atp-dependent rna helicase FFE93_007015 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FFE93_007030 ENOG41061WM D-Alanyl-D-Alanine FFE93_007035 ENOG4105CXG d-lactate dehydrogenase FFE93_007045 ENOG4105N1F Hnh endonuclease FFE93_007055 ENOG4105Y3U Transglycosylase-associated protein FFE93_007065 ENOG4105EHI Phosphonate ABC transporter, periplasmic FFE93_007080 ENOG4108W15 Protein of unknown function (DUF1456) FFE93_007085 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FFE93_007090 ENOG4105C32 Amino acid ABC transporter (Permease) FFE93_007095 ENOG4105CNN ABC, transporter FFE93_007100 ENOG4105D5T phosphonate abc transporter FFE93_007105 ENOG4108IV0 ABC, transporter FFE93_007110 ENOG4105KHC sulfurtransferase FFE93_007160 ENOG4108R7K Metal Dependent Phosphohydrolase FFE93_007180 ENOG4105C3F Signal peptidase i FFE93_007190 ENOG4108S1U FFE93_007200 ENOG4105CAR Terminase, large subunit FFE93_007215 ENOG4108ZUE Phage regulatory protein rha FFE93_007220 ENOG4108MXB Protein of unknown function (DUF968) FFE93_007265 ENOG4105CAR Terminase, large subunit FFE93_007275 ENOG4105EFC phage portal protein HK97 family FFE93_007320 ENOG4105TKZ Tail Sheath FFE93_007370 ENOG4108T86 baseplate J family protein FFE93_007375 ENOG4105Y0G tail protein FFE93_007380 ENOG4105Y9F tail fiber protein FFE93_007400 ENOG4105E68 Sulfatase FFE93_007405 ENOG4105PAN UPF0352 protein FFE93_007410 ENOG4106V8H Nucleoid-associated protein FFE93_007420 ENOG4105CFI type iii restriction protein res subunit FFE93_007425 ENOG4105I08 Pseudouridine synthase FFE93_007430 ENOG4105C2C drug resistance transporter, Bcr CflA FFE93_007435 ENOG4105HG6 FFE93_007440 ENOG4108JQ5 ABC transporter FFE93_007445 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FFE93_007450 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FFE93_007455 ENOG4105E43 Extracellular solute-binding protein, family 5 FFE93_007460 ENOG4105CXC rtn protein FFE93_007465 ENOG4107TT5 NLP P60 protein FFE93_007470 ENOG41076MN Phosphoesterase, PA-phosphatase related FFE93_007475 ENOG4105CKI cobalamin synthesis protein FFE93_007485 ENOG4107YCY Transcriptional regulator FFE93_007490 ENOG4105DEI Mannitol dehydrogenase FFE93_007500 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FFE93_007505 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FFE93_007515 ENOG4105KRS Proteinase inhibitor FFE93_007520 ENOG4107QY8 reductase FFE93_007525 ENOG4105CUW cytochrome C-TYPE protein FFE93_007535 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FFE93_007540 ENOG4105DE4 1-phosphofructokinase FFE93_007545 ENOG4105DM4 PTS System FFE93_007550 ENOG4105EKQ RNA-directed DNA polymerase FFE93_007555 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FFE93_007560 ENOG4105HMI Membrane FFE93_007570 ENOG4105DUM transcriptional regulator, lysR family FFE93_007575 ENOG4108IQI permease FFE93_007590 ENOG4105D05 Receptor FFE93_007595 ENOG4108TGY Glutathione S-transferase FFE93_007610 ENOG4105D01 (LipO)protein FFE93_007620 ENOG4108UMI ABC transporter, permease FFE93_007635 ENOG4105C28 cystathionine FFE93_007645 ENOG4105DZ1 carboxypeptidase FFE93_007650 ENOG4105EJQ L-serine dehydratase FFE93_007655 ENOG4105C44 Serine transporter FFE93_007660 ENOG4107FB0 transcriptional regulator DeoR family FFE93_007665 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FFE93_007670 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FFE93_007700 ENOG4105MEH FFE93_007750 ENOG4105ED4 portal protein FFE93_007775 ENOG4105D0C transport protein FFE93_007780 ENOG41090BQ Glutaredoxin FFE93_007785 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FFE93_007795 ENOG4108RMJ sensory transduction regulator FFE93_007800 ENOG4107RUE extracellular solute-binding protein family 1 FFE93_007805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FFE93_007810 ENOG4105F38 ABC transporter, permease FFE93_007815 ENOG4105D38 putrescine abc transporter FFE93_007820 ENOG4105RBQ inner membrane protein ybjO FFE93_007830 ENOG4106TNF Periplasmic binding protein FFE93_007835 ENOG4105DMR ABC, transporter FFE93_007840 ENOG4105GBT ABC transporter FFE93_007845 ENOG4106PMH Extracellular solute-binding protein family 3 FFE93_007850 ENOG4105E5Z arginine transporter ATP-binding subunit FFE93_007855 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) FFE93_007860 ENOG41064MM (LipO)protein FFE93_007865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FFE93_007870 ENOG4105CGD Nad-dependent epimerase dehydratase FFE93_007875 ENOG4105C5W Aldolase FFE93_007880 ENOG4105JQZ Methyltransferase FFE93_007885 ENOG4105C7K acetolactate synthase FFE93_007890 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FFE93_007895 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FFE93_007900 ENOG4105DWU Membrane FFE93_007905 ENOG4105CPB ATP-dependent endonuclease of the OLD family FFE93_007910 ENOG4108MJ5 VirK protein FFE93_007915 ENOG4105DJY efflux transporter, rnd family, mfp subunit FFE93_007925 ENOG4105VEQ Cold shock protein FFE93_007930 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FFE93_007935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FFE93_007940 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FFE93_007945 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FFE93_007950 ENOG4108JJ8 (ABC) transporter FFE93_007955 ENOG4108JJ9 ABC, transporter FFE93_007960 ENOG4105C3M thioredoxin reductase FFE93_007965 ENOG4105EW9 transcriptional regulator AsnC family FFE93_007970 ENOG4105CNU cell division protein FtsK FFE93_007975 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FFE93_007980 ENOG4105D1H recombination factor protein RarA FFE93_007985 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FFE93_007990 ENOG4108ISG Major Facilitator FFE93_007995 ENOG4105F1A Pyruvate formate-lyase FFE93_008000 ENOG4105C6N Formate acetyltransferase FFE93_008005 ENOG4105TMB Formate nitrite transporter FFE93_008010 ENOG4105DDY UPF0142 protein ycaO FFE93_008015 ENOG4105HDK L-asparaginase FFE93_008020 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FFE93_008025 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FFE93_008035 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FFE93_008040 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FFE93_008045 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FFE93_008060 ENOG4105E32 cytoplasmic protein FFE93_008070 ENOG4105VEQ Cold shock protein FFE93_008075 ENOG4105W49 UPF0434 protein FFE93_008085 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FFE93_008090 ENOG4107S90 membrAne FFE93_008095 ENOG4106371 Methyltransferase FFE93_008100 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FFE93_008105 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FFE93_008115 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FFE93_008120 ENOG4105EAQ (twin-arginine translocation) pathway signal FFE93_008125 ENOG4105C5X domain protein FFE93_008130 ENOG4105BZU Histidine kinase FFE93_008135 ENOG4105CGF Aromatic amino acid aminotransferase FFE93_008145 ENOG4105C5S asparaginyl-tRNA synthetase FFE93_008150 ENOG4107RH7 Nicotinate phosphoribosyltransferase FFE93_008155 ENOG4105CD8 aminopeptidase N FFE93_008160 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FFE93_008165 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FFE93_008170 ENOG4105QVC MOSC domain-containing protein FFE93_008175 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FFE93_008180 ENOG4105C5H ABC transporter FFE93_008185 ENOG4105F1S paraquat-inducible protein a FFE93_008190 ENOG4105DY2 Paraquat-inducible protein b FFE93_008195 ENOG4108Q2G (LipO)protein FFE93_008200 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FFE93_008205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FFE93_008215 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FFE93_008220 ENOG4105DAN ATP-dependent protease FFE93_008225 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FFE93_008230 ENOG4105UYK outer membrane protein a FFE93_008235 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) FFE93_008240 ENOG4108RZ1 DNA transformation protein FFE93_008245 ENOG4105EM2 membrane FFE93_008250 ENOG410901E Membrane FFE93_008255 ENOG41088T4 Helicase IV FFE93_008265 ENOG4108Q67 UPF0319 protein FFE93_008270 ENOG4105K4P CoA-binding domain protein FFE93_008275 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) FFE93_008285 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FFE93_008290 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FFE93_008335 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FFE93_008340 ENOG4105FAW cDP-glucose 4,6-dehydratase FFE93_008345 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FFE93_008350 ENOG4108EX3 reductase FFE93_008385 ENOG4105EAU Plays a role in nitrite reduction (By similarity) FFE93_008390 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit FFE93_008395 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FFE93_008400 ENOG4105DVI reductase, NrfD FFE93_008405 ENOG4105DA4 cytochrome c-type biogenesis protein FFE93_008410 ENOG4107QX9 Thiol disulfide interChange protein FFE93_008420 ENOG4108W0S formate-dependent nitrite reductase complex FFE93_008425 ENOG4105VJY transcriptional regulator FFE93_008430 ENOG4107YC3 synthase FFE93_008440 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FFE93_008450 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) FFE93_008455 ENOG4105DJ9 glucan biosynthesis protein FFE93_008460 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FFE93_008465 ENOG4105NAC (LipO)protein FFE93_008475 ENOG4105DUX Transporter FFE93_008480 ENOG4105MGM doxx family FFE93_008485 ENOG4105D1S lipid A biosynthesis FFE93_008490 ENOG4108ZXC Two component transcriptional regulator, luxr family FFE93_008495 ENOG4106AFQ Histidine kinase FFE93_008500 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FFE93_008505 ENOG4106WHD Tetrathionate reductase FFE93_008510 ENOG4105DB1 molybdopterin oxidoreductase FFE93_008525 ENOG4105DSF transport protein FFE93_008545 ENOG4105PVA Biofilm formation regulatory protein BssS FFE93_008555 ENOG4105EKE dihydroorotase FFE93_008560 ENOG41067V3 Antibiotic biosynthesis monooxygenase FFE93_008565 ENOG4107QQB Ribonuclease E FFE93_008570 ENOG4105EI2 Pseudouridine synthase FFE93_008580 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FFE93_008585 ENOG4105VGS 50s ribosomal protein l32 FFE93_008590 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FFE93_008600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FFE93_008605 ENOG4105CHR reductase FFE93_008615 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FFE93_008620 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FFE93_008625 ENOG4105HHA aminodeoxychorismate lyase FFE93_008630 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FFE93_008635 ENOG4107QRG dna polymerase iii FFE93_008640 ENOG4105F8V Hydrolase, tatD family FFE93_008645 ENOG4105CI1 PTS System FFE93_008655 ENOG4108JJA ABC, transporter FFE93_008660 ENOG4108MBX Secretion Protein FFE93_008665 ENOG4105C4X radical SAM domain protein FFE93_008675 ENOG4105F9E Shikimate 5-dehydrogenase FFE93_008680 ENOG4105K59 histidine triad (HIT) protein FFE93_008685 ENOG41090DQ Lipoprotein FFE93_008690 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FFE93_008705 ENOG4105D0Y UPF0227 protein FFE93_008710 ENOG4105CEP NADH dehydrogenase FFE93_008715 ENOG4107MBR 17 kDa surface antigen FFE93_008720 ENOG4108JA2 transcriptioN-repair coupling factor FFE93_008725 ENOG4105D60 lipoprotein releasing system transmembrane protein FFE93_008735 ENOG4105D60 lipoprotein releasing system transmembrane protein FFE93_008740 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FFE93_008745 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FFE93_008760 ENOG4105EZE Cupin 4 family protein FFE93_008770 ENOG4105XJC Two component transcriptional regulator (Winged helix family FFE93_008775 ENOG4107QTF adenylosuccinate lyase FFE93_008780 ENOG41075W9 High frequency lysogenization protein HflD homolog FFE93_008785 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FFE93_008795 ENOG4108R99 pseudouridine synthase FFE93_008800 ENOG4108HMX isocitrate dehydrogenase (NADP) FFE93_008810 ENOG4108HCJ Hydrolase FFE93_008820 ENOG4105C85 amino acid FFE93_008830 ENOG4108MRH transcriptional regulatory protein FFE93_008835 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FFE93_008840 ENOG4105CSV Glutaminase FFE93_008850 ENOG4105DDV Transcriptional regulator (LacI family FFE93_008855 ENOG4105VZJ PTS System FFE93_008860 ENOG4105CK1 PTS System FFE93_008865 ENOG4105CS2 ec 3.2.1.21 FFE93_008870 ENOG4105VCP PTS System FFE93_008880 ENOG4107SJW iron permease, FTR1 FFE93_008895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FFE93_008905 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FFE93_008925 ENOG4108819 ferric iron reductase FFE93_008930 ENOG4107RAQ aminopeptidase FFE93_008935 ENOG4108TUY outer membrane protein PgaA FFE93_008940 ENOG4107BJW polysaccharide deacetylase FFE93_008945 ENOG4105CND Glycosyl transferase, family 2 FFE93_008950 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD FFE93_008965 ENOG4105D5M phosphate starvation-inducible protein FFE93_008970 ENOG4105EWV Sodium calcium exchanger membrane region FFE93_008975 ENOG4105Q26 Siderophore-interacting protein FFE93_008985 ENOG4107R11 Transcriptional regulator FFE93_008990 ENOG4105BZU Histidine kinase FFE93_009000 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FFE93_009005 ENOG4105C4M (Ubiquinol oxidase) subunit I FFE93_009010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FFE93_009015 ENOG4105C8Y Acetylornithine aminotransferase FFE93_009020 ENOG4105F4X arginine FFE93_009030 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FFE93_009035 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FFE93_009050 ENOG4105CI2 imidazolone-5-propionate hydrolase FFE93_009055 ENOG4105CZE histidine utilization repressor FFE93_009060 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FFE93_009065 ENOG41090B9 response to stress FFE93_009070 ENOG4108MEK Metal-binding protein YodA FFE93_009080 ENOG4108K5P (LipO)protein FFE93_009085 ENOG4107SET aldo keto reductase FFE93_009120 ENOG4105ENX hydrolase FFE93_009130 ENOG4105C3G gtp-binding protein FFE93_009140 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FFE93_009145 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FFE93_009150 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FFE93_009160 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FFE93_009165 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FFE93_009175 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FFE93_009180 ENOG4108YY7 Invasion gene expression up-regulator SirB FFE93_009185 ENOG41063JG Transcriptional regulator FFE93_009195 ENOG4105CHH sulfate transporter FFE93_009200 ENOG4105BZU Histidine kinase FFE93_009215 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FFE93_009225 ENOG4107XHZ cytoplasmic chaperone TorD family protein FFE93_009230 ENOG4105F3T (LipO)protein FFE93_009235 ENOG4105EV4 Multidrug resistance protein mdtH FFE93_009240 ENOG4105D9U N-acetyltransferase FFE93_009250 ENOG4105EP9 oxidoreductase FFE93_009255 ENOG4105CJR Integral membrane protein (MviN FFE93_009265 ENOG4106ZCM YecM protein FFE93_009270 ENOG4106N3A copper homeostasis protein cutc FFE93_009280 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FFE93_009290 ENOG4105WJG Glutathione FFE93_009295 ENOG4105D3W isochorismatase FFE93_009305 ENOG4105C9M aspartyl-trna synthetase FFE93_009310 ENOG4108TIT dATP pyrophosphohydrolase FFE93_009315 ENOG4105CDY transcriptional regulatory protein FFE93_009325 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FFE93_009330 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FFE93_009335 ENOG4105FAV ABC, transporter FFE93_009340 ENOG4105FDK ABC transporter FFE93_009345 ENOG4105NXV High-affinity zinc uptake system protein FFE93_009350 ENOG4105DR5 peptidase FFE93_009355 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FFE93_009360 ENOG4105CA9 Pyruvate kinase FFE93_009365 ENOG4106KNT transcriptional regulator FFE93_009370 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FFE93_009375 ENOG4108UHU Aldolase FFE93_009380 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FFE93_009390 ENOG4105M4H endoribonuclease L-psp FFE93_009395 ENOG4105DVT helicase FFE93_009400 ENOG41072GX Peptidase M22 Glycoprotease FFE93_009405 ENOG4105Y4Z Outer Membrane Lipoprotein FFE93_009410 ENOG4105CEY Amp-dependent synthetase and ligase FFE93_009415 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FFE93_009420 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FFE93_009425 ENOG4107QMS site-determining protein FFE93_009430 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FFE93_009440 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FFE93_009445 ENOG4108ZZ3 UPF0260 protein FFE93_009455 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FFE93_009460 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FFE93_009465 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FFE93_009475 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FFE93_009480 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FFE93_009485 ENOG4108V06 Glutathione peroxidase FFE93_009490 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FFE93_009495 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FFE93_009500 ENOG4105CKK Glycosyl transferase, family 2 FFE93_009510 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FFE93_009515 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FFE93_009520 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FFE93_009525 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FFE93_009530 ENOG4108QBX (LipO)protein FFE93_009535 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FFE93_009545 ENOG4107ENK receptor FFE93_009550 ENOG4107F3C Hemin uptake protein FFE93_009555 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FFE93_009560 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FFE93_009570 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FFE93_009580 ENOG4105IPI Membrane FFE93_009585 ENOG4105CQB FAD linked oxidase domain protein FFE93_009590 ENOG4105KA0 thioesterase Superfamily protein FFE93_009600 ENOG4108Z4V iron-sulfur cluster assembly FFE93_009605 ENOG4105DIW FeS assembly protein SUFB FFE93_009610 ENOG4105C3K feS assembly ATPase SufC FFE93_009615 ENOG4105JRK feS assembly protein SufD FFE93_009625 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FFE93_009630 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FFE93_009635 ENOG4105KMX major outer membrane lipoprotein FFE93_009640 ENOG4105CA9 Pyruvate kinase FFE93_009655 ENOG4107QI1 Mate efflux family protein FFE93_009660 ENOG4108R6K riboflavin synthase, subunit alpha FFE93_009665 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FFE93_009670 ENOG4105CZQ inner membrane transport protein YdhC FFE93_009675 ENOG4105F52 Transcriptional regulator FFE93_009680 ENOG4105ETE Transcriptional regulator (LacI family FFE93_009690 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FFE93_009695 ENOG4105K4H Nlp p60 protein FFE93_009700 ENOG4105M2J Glutaredoxin FFE93_009705 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FFE93_009710 ENOG4108UYE Lactoylglutathione lyase FFE93_009715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FFE93_009720 ENOG4108WUH Transcriptional regulator, TetR family FFE93_009725 ENOG4105DIJ Phosphoethanolamine transferase FFE93_009730 ENOG4105XZD Fe-S protein FFE93_009735 ENOG4107RGM aldo keto reductase FFE93_009750 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) FFE93_009755 ENOG4108XTF Outer Membrane Lipoprotein FFE93_009760 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FFE93_009765 ENOG410642K Lysozyme inhibitor FFE93_009775 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FFE93_009785 ENOG4108K3A Glutathione S-transferase FFE93_009790 ENOG4108ZR5 Conserved Protein FFE93_009795 ENOG41069YE inner membrane protein yohC FFE93_009805 ENOG4105DUX Transporter FFE93_009810 ENOG4105Q4T oxidoreductase FFE93_009820 ENOG4108JQ2 peptide transport system atp-binding protein FFE93_009825 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FFE93_009830 ENOG4108EU3 peptide transport system, permease FFE93_009835 ENOG4108I5W peptide transport system, permease protein FFE93_009840 ENOG4108HIY periplasmic FFE93_009850 ENOG4105E51 psp operon transcriptional activator FFE93_009855 ENOG41087YS Phage shock protein A FFE93_009860 ENOG4105YYT phage shock protein B FFE93_009865 ENOG4105FM1 phage shock protein C FFE93_009875 ENOG4105CM6 amino acid regulated cytosolic protein FFE93_009880 ENOG4106K28 UPF0283 membrane protein FFE93_009900 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FFE93_009905 ENOG4107S8C mandelate racemase muconate lactonizing FFE93_009910 ENOG4105KXI murein peptide amidase A FFE93_009915 ENOG4107QSI ABC, transporter FFE93_009935 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FFE93_009940 ENOG4105CID antiterminator FFE93_009945 ENOG4105C5Y PTS System FFE93_009950 ENOG4105CS2 ec 3.2.1.21 FFE93_009955 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FFE93_009965 ENOG4105KT7 mgtC SapB transporter FFE93_009975 ENOG4105C5I Dehydrogenase FFE93_009980 ENOG4107H52 Dicarboxylate transport FFE93_009985 ENOG410689M (LipO)protein FFE93_009990 ENOG4105WXT Conserved Protein FFE93_010010 ENOG4105CSH Transporter FFE93_010015 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FFE93_010020 ENOG4105CQ7 ATP-dependent helicase FFE93_010035 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FFE93_010040 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FFE93_010045 ENOG4105CTD carboxy-peptidase FFE93_010050 ENOG4105JJR Histidine kinase FFE93_010055 ENOG4107EXC regulatoR FFE93_010065 ENOG4105D5Q Arginine ornithine antiporter FFE93_010070 ENOG4105C5D exported protein FFE93_010075 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FFE93_010080 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FFE93_010085 ENOG4105Q9Y Universal stress protein FFE93_010090 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FFE93_010095 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FFE93_010105 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FFE93_010135 ENOG4105PAD Hydrolase FFE93_010145 ENOG4105E5D amino acid FFE93_010150 ENOG4105CVK Glutamate decarboxylase FFE93_010155 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FFE93_010175 ENOG4105FYV Amp nucleosidase FFE93_010185 ENOG4106V2I dimethylaminohydrolase FFE93_010190 ENOG4105E89 ABC transporter FFE93_010195 ENOG4105DSP amino acid AbC transporter FFE93_010205 ENOG4108RYR transcriptional regulator AsnC family FFE93_010215 ENOG4105CYM Glutathione S-transferase FFE93_010235 ENOG4105KBH arsR family transcriptional regulator FFE93_010240 ENOG4107R5R arsenical pump membrane protein FFE93_010250 ENOG4105TDT uncharacterized protein yahO FFE93_010255 ENOG4105EMU Dehydrogenase FFE93_010285 ENOG4105M5Q UPF0482 protein FFE93_010290 ENOG4105KBG Protein of unknown function (DUF1161) FFE93_010310 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FFE93_010315 ENOG4105DAG ROK family FFE93_010340 ENOG4106NZI LysR family Transcriptional regulator FFE93_010345 ENOG4105D94 Major Facilitator Superfamily FFE93_010365 ENOG4105F27 Major Facilitator FFE93_010385 ENOG4105C9Q fumarate hydratase class II FFE93_010390 ENOG4105EIP mannose-6-phosphate isomerase FFE93_010395 ENOG4106J39 exported protein FFE93_010405 ENOG4107P2S Transcriptional regulator FFE93_010410 ENOG4105CI1 PTS System FFE93_010415 ENOG4105C87 Aminotransferase class I and II FFE93_010425 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FFE93_010430 ENOG4105DHU Bile acid FFE93_010435 ENOG4105D9R oxidoreductase FFE93_010445 ENOG4105CNN ABC, transporter FFE93_010455 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FFE93_010470 ENOG4108JJA ABC, transporter FFE93_010475 ENOG4105C42 Type I secretion membrane fusion protein (HlyD FFE93_010480 ENOG4108JJA ABC, transporter FFE93_010485 ENOG4105CKU formyltetrahydrofolate synthetase FFE93_010490 ENOG4105M9B inner membrane protein ydgK FFE93_010495 ENOG4105DGN Electron transport complex FFE93_010505 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) FFE93_010510 ENOG4105UEI Transcriptional Regulator AraC Family FFE93_010520 ENOG4108UQQ Electron transport complex FFE93_010530 ENOG4105CSM endonuclease III FFE93_010535 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FFE93_010540 ENOG4105D22 carbon starvation protein FFE93_010545 ENOG4105VCD cytoplasmic protein FFE93_010550 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FFE93_010555 ENOG4105N2W Transcriptional regulator FFE93_010560 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FFE93_010565 ENOG41061RM osmotically inducible lipoprotein FFE93_010570 ENOG4108ZJT translation initiation factor, Sui1 FFE93_010575 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FFE93_010580 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FFE93_010590 ENOG4105CFV Tetratricopeptide repeat protein FFE93_010595 ENOG4105Q4A inner membrane protein yciS FFE93_010600 ENOG4105EYK Phosphatidylglycerophosphatase B FFE93_010605 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FFE93_010610 ENOG4107QM5 aconitate hydratase FFE93_010625 ENOG4107R11 Transcriptional regulator FFE93_010630 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FFE93_010640 ENOG4105RKX Protein of unknown function (DUF2498) FFE93_010645 ENOG4105ERU peptidase FFE93_010650 ENOG4105UBK short-chain dehydrogenase reductase FFE93_010655 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FFE93_010665 ENOG4105FE9 pseudouridine synthase FFE93_010670 ENOG4108Q9V regulatoR FFE93_010680 ENOG4107RTD sua5 ycio yrdc ywlc family protein FFE93_010685 ENOG4105DB7 PHP domain protein FFE93_010700 ENOG4105DDQ anthranilate synthase FFE93_010710 ENOG4105DK0 Indole-3-glycerol phosphate synthase FFE93_010715 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FFE93_010730 ENOG4105EIF outer membrane protein W FFE93_010740 ENOG4108S3I UPF0259 membrane protein FFE93_010750 ENOG4107835 probably involved in intracellular septation (By similarity) FFE93_010755 ENOG4105NAU thioesterase Superfamily protein FFE93_010760 ENOG410822N TonB family FFE93_010765 ENOG4105K9H YciI-like protein FFE93_010780 ENOG4105CMB EAL domain-containing protein FFE93_010790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FFE93_010800 ENOG4108JQ7 (ABC) transporter FFE93_010805 ENOG4105C3U ABC transporter FFE93_010810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FFE93_010815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FFE93_010820 ENOG4107QSI ABC, transporter FFE93_010830 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FFE93_010840 ENOG4108EKI Dehydrogenase FFE93_010845 ENOG4107104 thymidine kinase FFE93_010860 ENOG4105C6Y Udp-glucose 6-dehydrogenase FFE93_010865 ENOG4105I93 response regulator FFE93_010870 ENOG4105D78 K07001 NTE family protein FFE93_010880 ENOG4105K5B UPF0225 protein FFE93_010885 ENOG4105CIY formyltetrahydrofolate deformylase FFE93_010925 ENOG4105SKE transcriptional Regulator LysR family FFE93_010930 ENOG4105CGK Exodeoxyribonuclease III FFE93_010935 ENOG4105M6F mutator MutT protein FFE93_010940 ENOG4105MTM Protein of unknown function (DUF1496) FFE93_010945 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FFE93_010960 ENOG41069NU Nitroreductase FFE93_010965 ENOG4105D07 Signal peptide peptidase, SppA FFE93_010970 ENOG4105HDK L-asparaginase FFE93_010975 ENOG4108RWI nicotinamidase FFE93_010980 ENOG4105VUT cytoplasmic protein FFE93_010995 ENOG4105DSB aldose 1-epimerase FFE93_011005 ENOG4105GNX MltA-interacting MipA family protein FFE93_011015 ENOG4105CYN Serine protein kinase FFE93_011020 ENOG4106AKX UPF0229 protein FFE93_011030 ENOG4105HEI LysR family (Transcriptional regulator FFE93_011035 ENOG4105EUB pirin domain protein FFE93_011040 ENOG4105BZU Histidine kinase FFE93_011045 ENOG4105CNH Multidrug resistance protein MdtL FFE93_011050 ENOG4105DJY efflux transporter, rnd family, mfp subunit FFE93_011060 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FFE93_011065 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FFE93_011075 ENOG4105ED1 spovr family FFE93_011085 ENOG4105MZU cell filamentation protein FFE93_011140 ENOG4105ZTC transcriptional activator, Ogr delta FFE93_011145 ENOG4105YB8 TM2 domain containing protein FFE93_011150 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FFE93_011170 ENOG41082NX 50s ribosomal protein l35 FFE93_011175 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FFE93_011185 ENOG41087WU FFE93_011190 ENOG4108UQV Membrane FFE93_011215 ENOG41082NP Multiple antibiotic resistance FFE93_011220 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FFE93_011225 ENOG4105DSE periplasmic solute binding protein FFE93_011230 ENOG4105DIK (ABC) transporter FFE93_011235 ENOG4105CC5 ABC transporter FFE93_011240 ENOG4105CC5 ABC transporter FFE93_011245 ENOG4105FGM Fructosamine kinase FFE93_011255 ENOG4107PN8 YfeABCD locus regulator FFE93_011260 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FFE93_011265 ENOG4105M5J Cupin 2, conserved barrel domain protein FFE93_011270 ENOG4105CHR reductase FFE93_011275 ENOG41061NF Pectate lyase FFE93_011280 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FFE93_011285 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FFE93_011300 ENOG4108PU9 oligogalacturonate-specific porin FFE93_011305 ENOG4107K5X Membrane-bound metal-dependent hydrolase FFE93_011310 ENOG4108ETY sodium dicarboxylate symporter FFE93_011315 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FFE93_011325 ENOG4105CAZ oligogalacturonide lyase FFE93_011330 ENOG4105C0R drug resistance transporter emrb qaca subfamily FFE93_011335 ENOG4105D0M Protease HtpX homolog FFE93_011340 ENOG4105CN1 protease FFE93_011350 ENOG4108ZGC gaf domain protein FFE93_011355 ENOG4105H2K paraquat-inducible protein a FFE93_011360 ENOG4105DY2 Paraquat-inducible protein b FFE93_011370 ENOG4105C0R drug resistance transporter emrb qaca subfamily FFE93_011410 ENOG4105WT8 Protein of unknown function (DUF1480) FFE93_011425 ENOG4108SHQ Glutathione S-transferase FFE93_011440 ENOG4105D3G Pseudouridine synthase FFE93_011445 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FFE93_011500 ENOG4105UZW Tail fiber assembly protein FFE93_011615 ENOG41090AG Bacteriophage protein FFE93_011625 ENOG4107ZQ5 Phage-associated protein, HI1409 family FFE93_011640 ENOG4105K4U addiction module toxin, RelE StbE family FFE93_011660 ENOG4108ES9 ParB domain protein nuclease FFE93_011670 ENOG4105D9P serine threonine protein kinase FFE93_011705 ENOG4105HRS Antitermination protein FFE93_011710 ENOG4105RWQ Protein of unknown function (DUF1364) FFE93_011765 ENOG41087BU transcriptional repressor DicA FFE93_011805 ENOG4108I1J Integrase FFE93_011810 ENOG4105NKT exported protein FFE93_011815 ENOG4108PNC copper resistance FFE93_011820 ENOG4105FXM Copper resistance protein FFE93_011825 ENOG41090A1 ferritin FFE93_011830 ENOG4105MPK DNA polymerase III subunit theta FFE93_011850 ENOG4105CUG Oligopeptidase b FFE93_011865 ENOG4105X2V dna damage-inducible protein FFE93_011870 ENOG4105C1J atp-dependent rna helicase FFE93_011875 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FFE93_011880 ENOG4105X5C UPF0181 protein FFE93_011890 ENOG4105P8F nudix hydrolase FFE93_011895 ENOG4105EJQ L-serine dehydratase FFE93_011900 ENOG4105EE5 Membrane protein terC FFE93_011905 ENOG4108EQA pts system FFE93_011910 ENOG4105ETZ PTS System FFE93_011915 ENOG4105F3R pts system mannose fructose sorbose family iid FFE93_011920 ENOG4108NK4 UPF0266 membrane protein FFE93_011925 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FFE93_011935 ENOG4105BZU Histidine kinase FFE93_011945 ENOG4105DHI Methyltransferase FFE93_011950 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FFE93_011955 ENOG4105EKQ RNA-directed DNA polymerase FFE93_011960 ENOG4105VEQ Cold shock protein FFE93_011965 ENOG410610J Protein of unknown function (DUF2627) FFE93_011970 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FFE93_011975 ENOG4105C85 amino acid FFE93_011990 ENOG41064PC FFE93_012000 ENOG4105TIK FFE93_012005 ENOG4105N4N Protein of unknown function (DUF2766) FFE93_012020 ENOG4105D5Q Arginine ornithine antiporter FFE93_012030 ENOG4105BZ1 (ABC) transporter FFE93_012055 ENOG4105XXV Acid-resistance protein FFE93_012060 ENOG4105KVH Transcriptional regulator FFE93_012065 ENOG4105ECR NmrA family FFE93_012070 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FFE93_012090 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FFE93_012140 ENOG4105VZ1 Replication Protein FFE93_012165 ENOG4105ED4 portal protein FFE93_012310 ENOG4105ZTC transcriptional activator, Ogr delta FFE93_012315 ENOG4105Y50 Virulence Protein FFE93_012355 ENOG4105UZW Tail fiber assembly protein FFE93_012405 ENOG4105E4C Lytic transglycosylase catalytic FFE93_012525 ENOG4105RWQ Protein of unknown function (DUF1364) FFE93_012555 ENOG4105CDU Replicative dna helicase FFE93_012585 ENOG4105EKQ RNA-directed DNA polymerase FFE93_012640 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FFE93_012645 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FFE93_012650 ENOG4105WH1 Two component transcriptional regulator luxr family FFE93_012655 ENOG4105XVG cytoplasmic protein FFE93_012660 ENOG4105RA2 Membrane FFE93_012670 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_012675 ENOG4105E5K Alpha-amylase FFE93_012710 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) FFE93_012725 ENOG4105CSH Transporter FFE93_012750 ENOG4105CK7 Sodium proline symporter FFE93_012755 ENOG4105C26 Dehydrogenase FFE93_012770 ENOG4105CDA abc transporter atp-binding protein FFE93_012775 ENOG4105E5Q amino acid AbC transporter FFE93_012780 ENOG4105EAB amino acid AbC transporter FFE93_012785 ENOG4105K6H D-cysteine desulfhydrase FFE93_012790 ENOG4108M9K flagella biosynthesis protein FliZ FFE93_012795 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FFE93_012800 ENOG4108C80 FliB family FFE93_012810 ENOG4105DTS flagellar hook-associated FFE93_012815 ENOG4105MQ3 flagellar protein FliS FFE93_012820 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) FFE93_012830 ENOG4105DHT Metal Dependent Phosphohydrolase FFE93_012840 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FFE93_012845 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FFE93_012850 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FFE93_012855 ENOG41090PJ Flagellar assembly protein FFE93_012860 ENOG4108JIR Flagellum-specific ATP synthase FFE93_012865 ENOG4105GSA Flagellar export protein flij FFE93_012870 ENOG4105WF4 Flagellar hook-length control protein FFE93_012875 ENOG4107ZI8 flagellar basal body-associated protein flil FFE93_012880 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FFE93_012885 ENOG4105DD5 Flagellar motor switch protein FFE93_012895 ENOG4105CN7 Flagellar biosynthetic protein FliP FFE93_012900 ENOG4105VS8 Flagellar biosynthetic protein fliq FFE93_012905 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FFE93_012910 ENOG4105DTJ flagellar hook-associated protein FFE93_012915 ENOG4105E1Q flagellar hook-associated protein FFE93_012920 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FFE93_012935 ENOG4105CGA flagellar basal-body rod protein FlgG FFE93_012940 ENOG4108KPB Flagellar basal-body rod protein FlgF FFE93_012945 ENOG4105BZE flagellar hook protein, FlgE FFE93_012950 ENOG4105W00 Flagellar hook capping protein FFE93_012955 ENOG4108ZC9 flagellar basal-body rod protein flgc FFE93_012960 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FFE93_012965 ENOG4105CKS Flagella basal body P-ring formation protein flgA FFE93_012970 ENOG4105M9M anti-sigma28 factor FlgM FFE93_012975 ENOG4105QVD Flagella synthesis protein FlgN FFE93_012980 ENOG4105W13 flagellar protein FFE93_012985 ENOG4105D7B Flagellar biosynthesis protein flha FFE93_012990 ENOG4105D00 flagellar biosynthetic protein flhB FFE93_012995 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FFE93_013000 ENOG4108VYJ response regulator receiver protein FFE93_013010 ENOG4105BZU Histidine kinase FFE93_013015 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_013020 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_013035 ENOG4108V3W Chemotaxis protein, CheW FFE93_013040 ENOG4105CBS Chea signal transduction histidine kinase FFE93_013045 ENOG4105ER2 Ompa motb domain protein FFE93_013050 ENOG4107RD7 Flagellar Motor Protein, MotA FFE93_013055 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FFE93_013060 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) FFE93_013065 ENOG4108VA4 Universal stress protein FFE93_013070 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FFE93_013075 ENOG4105KT7 mgtC SapB transporter FFE93_013080 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_013085 ENOG4105VZF DsrB protein FFE93_013090 ENOG4105VEQ Cold shock protein FFE93_013095 ENOG4105ETE Transcriptional regulator (LacI family FFE93_013100 ENOG4105CNT hydrolase family 2 FFE93_013110 ENOG4105GSJ Inner membrane protein ylaC FFE93_013115 ENOG4105J0Q Transcriptional regulator FFE93_013125 ENOG41061EV selenium-binding protein YdfZ FFE93_013130 ENOG4105D6F Phosphatase FFE93_013135 ENOG4108S1B Periplasmic chaperone protein FFE93_013140 ENOG4108D1K outer membrane usher protein FFE93_013150 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FFE93_013165 ENOG4108TSE Transferase FFE93_013170 ENOG4107QPK )-transporter FFE93_013185 ENOG4105CHY citrate lyase, alpha FFE93_013190 ENOG4105CI0 Citrate lyase FFE93_013195 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) FFE93_013200 ENOG4105DUA (citrate (pro-3S)-lyase ligase FFE93_013205 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FFE93_013210 ENOG4106YYS transcriptional regulatory protein FFE93_013215 ENOG4108KX4 response regulator FFE93_013220 ENOG4105BZU Histidine kinase FFE93_013225 ENOG4105CXY transporter FFE93_013230 ENOG4105C4Y ABC transporter FFE93_013235 ENOG4107RCV ABC transporter, permease FFE93_013240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FFE93_013250 ENOG4108Q9V regulatoR FFE93_013255 ENOG4105BZU Histidine kinase FFE93_013265 ENOG4105GQR Chaperone FFE93_013270 ENOG4105CW0 outer membrane usher protein FFE93_013280 ENOG4108MQF Chaperone FFE93_013285 ENOG4105FE9 pseudouridine synthase FFE93_013295 ENOG4105C5H ABC transporter FFE93_013300 ENOG4107R88 Chemotaxis protein (CheV) FFE93_013305 ENOG4105UQX Mate efflux family protein FFE93_013310 ENOG4105CDH Citrulline--aspartate ligase FFE93_013315 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FFE93_013320 ENOG4108TGR phosphatase FFE93_013325 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FFE93_013330 ENOG4108YZT Adenosylcobinamide kinase FFE93_013335 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FFE93_013345 ENOG4108V4M Cobalt abc transporter FFE93_013355 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) FFE93_013360 ENOG4105DVK Precorrin-2 c20-methyltransferase FFE93_013365 ENOG4107PPM cobalt chelatase FFE93_013370 ENOG4105QUC reductase FFE93_013375 ENOG4105E4R Precorrin-3B C17-methyltransferase FFE93_013380 ENOG4108P62 biosynthesis protein (CbiG) FFE93_013385 ENOG4105CIA precorrin-4 C(11)-methyltransferase FFE93_013390 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase FFE93_013395 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase FFE93_013400 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FFE93_013405 ENOG41081F0 Precorrin-8x methylmutase FFE93_013410 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FFE93_013415 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FFE93_013420 ENOG4107XVH Transcriptional regulator FFE93_013425 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FFE93_013430 ENOG4105KNY Microcompartments protein FFE93_013435 ENOG4105EHR propanediol utilization protein pduB FFE93_013440 ENOG4105DMB glycerol dehydratase FFE93_013445 ENOG4105YCI dehydratase medium subunit FFE93_013450 ENOG4108ZFT Dehydratase small subunit FFE93_013455 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit FFE93_013465 ENOG4105KNY Microcompartments protein FFE93_013470 ENOG4105KNY Microcompartments protein FFE93_013475 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) FFE93_013485 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FFE93_013495 ENOG4108EKI Dehydrogenase FFE93_013505 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) FFE93_013515 ENOG4105M3W utilization protein FFE93_013520 ENOG4105KTW ethanolamine utilization protein FFE93_013525 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FFE93_013530 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FFE93_013535 ENOG4107QZB decarboxylase FFE93_013540 ENOG4105JZC GHMP kinase FFE93_013545 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FFE93_013550 ENOG4105C2J ABC transporter FFE93_013555 ENOG4105CNN ABC, transporter FFE93_013565 ENOG41090HJ UPF0265 protein FFE93_013575 ENOG4105CJB Exodeoxyribonuclease I FFE93_013580 ENOG4105CUB amino acid FFE93_013590 ENOG4107SCQ Iron-containing alcohol dehydrogenase FFE93_013595 ENOG4105C2J ABC transporter FFE93_013600 ENOG4105CNN ABC, transporter FFE93_013605 ENOG4108535 NAD dependent epimerase/dehydratase family FFE93_013615 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FFE93_013620 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FFE93_013625 ENOG4105CIH Imidazole acetol-phosphate transaminase FFE93_013630 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FFE93_013635 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FFE93_013640 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FFE93_013645 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FFE93_013650 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FFE93_013655 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FFE93_013660 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FFE93_013665 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FFE93_013675 ENOG4105E2K Glycosyl transferase (Group 1 FFE93_013680 ENOG4108DMA Nad-dependent epimerase dehydratase FFE93_013685 ENOG4105C0K Gdp-mannose 4,6-dehydratase FFE93_013700 ENOG4105EY8 ABC transporter FFE93_013720 ENOG4105EE5 Membrane protein terC FFE93_013725 ENOG4105CEE C4-dicarboxylate transporter FFE93_013730 ENOG4108GAE asmA family FFE93_013740 ENOG4105DBI uridine monophosphokinase FFE93_013745 ENOG4105D1F ATP-binding protein FFE93_013750 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FFE93_013765 ENOG4105E5W Transporter FFE93_013770 ENOG4105VAW lrga family FFE93_013775 ENOG41067MG lrgb family FFE93_013785 ENOG4107R1I NAD-dependent malic enzyme FFE93_013795 ENOG4107GZ4 SanA protein FFE93_013810 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FFE93_013815 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FFE93_013820 ENOG4108JPZ Monovalent cation H antiporter subunit D FFE93_013825 ENOG4107TDF Formate hydrogenlyase subunit 4 FFE93_013830 ENOG4105D65 subunit l FFE93_013835 ENOG4107WQX hydrogenase 4 membrane subunit FFE93_013840 ENOG4108JPZ Monovalent cation H antiporter subunit D FFE93_013845 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FFE93_013855 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FFE93_013860 ENOG4105I6X formate hydrogenlyase maturation FFE93_013865 ENOG4108MG9 hydrogenase 3 maturation protease FFE93_013870 ENOG4108RC0 Electron transport protein FFE93_013875 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FFE93_013880 ENOG4108JUA Transcriptional regulator FFE93_013885 ENOG4107SDZ Galactoside transport system permease protein mglC FFE93_013900 ENOG41060NJ transcriptional regulator FFE93_013905 ENOG4105DHF Membrane FFE93_013910 ENOG4105EUJ GTP cyclohydrolase i FFE93_013915 ENOG4105CBP Major Facilitator FFE93_013920 ENOG4105EGI Transcriptional regulator FFE93_013950 ENOG4105C19 ABC transporter FFE93_013965 ENOG4105CVM Molybdenum cofactor synthesis domain protein FFE93_013970 ENOG4105D06 uba thif-type nad fad binding protein FFE93_013975 ENOG4105C5H ABC transporter FFE93_013995 ENOG4108T1M outer membrane protein x FFE93_014030 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FFE93_014035 ENOG4105KSC Transcriptional regulator, TraR DksA family FFE93_014040 ENOG4107R0W ABC transporter FFE93_014045 ENOG4105E5Q amino acid AbC transporter FFE93_014050 ENOG4105CDA abc transporter atp-binding protein FFE93_014055 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FFE93_014070 ENOG4108MTB glycosyl transferase family FFE93_014075 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FFE93_014080 ENOG4105DVT helicase FFE93_014095 ENOG4105FDR Membrane FFE93_014105 ENOG4105CXN decarboxylase FFE93_014110 ENOG4105D5Q Arginine ornithine antiporter FFE93_014115 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FFE93_014120 ENOG4108IJ8 ABC transporter FFE93_014125 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FFE93_014130 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FFE93_014135 ENOG4105CS2 ec 3.2.1.21 FFE93_014140 ENOG4105C5Y PTS System FFE93_014145 ENOG4108Q3X Transcriptional regulator FFE93_014155 ENOG4105Y50 Virulence Protein FFE93_014165 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_014175 ENOG4105CT4 transporter FFE93_014180 ENOG4107R6D beta-lactam binding protein AmpH FFE93_014205 ENOG4106UW1 Major Facilitator superfamily FFE93_014210 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FFE93_014215 ENOG41068CG regulatoR FFE93_014220 ENOG4105BZU Histidine kinase FFE93_014225 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FFE93_014230 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FFE93_014235 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FFE93_014240 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FFE93_014245 ENOG4105XPH Ferredoxin FFE93_014250 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) FFE93_014255 ENOG4105DDI hemolysin-type calcium-binding region FFE93_014280 ENOG4105E0U tyrosine-specific transport protein FFE93_014285 ENOG4108UII YfaZ family FFE93_014290 ENOG4105CH6 catalase FFE93_014295 ENOG4105CEY Amp-dependent synthetase and ligase FFE93_014300 ENOG4105DNI Converts SHCHC to OSB (By similarity) FFE93_014305 ENOG4108IPT Naphthoate synthase FFE93_014315 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FFE93_014320 ENOG4105E4F Isochorismate synthase FFE93_014335 ENOG4105TNS Conserved Protein FFE93_014340 ENOG4105C01 Dihydroxy-acid dehydratase FFE93_014355 ENOG4105C5I Dehydrogenase FFE93_014360 ENOG4105K2J Transcriptional regulator FFE93_014365 ENOG4105CHR reductase FFE93_014370 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FFE93_014380 ENOG4108UQ5 membrane protein YcdZ FFE93_014385 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FFE93_014390 ENOG4105C8S subunit m FFE93_014395 ENOG4105D65 subunit l FFE93_014400 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FFE93_014405 ENOG4107UFS subunit j FFE93_014410 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FFE93_014415 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FFE93_014420 ENOG4108IEH NADH dehydrogenase subunit g FFE93_014425 ENOG4107QIZ NADH dehydrogenase FFE93_014430 ENOG4105GKE subunit e FFE93_014435 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FFE93_014440 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FFE93_014445 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FFE93_014450 ENOG4107NQ8 LysR family Transcriptional regulator FFE93_014455 ENOG4105CHM Aminotransferase FFE93_014460 ENOG4105DK2 UPF0207 protein FFE93_014470 ENOG4107QWE )-transporter FFE93_014480 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FFE93_014485 ENOG4105XWI UPF0304 protein FFE93_014490 ENOG4105PQ6 UPF0208 membrane protein FFE93_014500 ENOG4105C6K Malic enzyme FFE93_014505 ENOG4107P2S Transcriptional regulator FFE93_014520 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FFE93_014530 ENOG4105E0C molybdate abc transporter FFE93_014535 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FFE93_014540 ENOG410680R Protein of unknown function (DUF2592) FFE93_014545 ENOG4105F4R Transcriptional regulator mode FFE93_014550 ENOG4105DKW ABC transporter FFE93_014560 ENOG4105CMR udp-glucose 4-epimerase FFE93_014565 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FFE93_014570 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FFE93_014575 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FFE93_014580 ENOG4105VIF phosphate starvation-inducible protein FFE93_014585 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FFE93_014590 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FFE93_014595 ENOG4105PGM cation diffusion facilitator family transporter FFE93_014600 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FFE93_014605 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FFE93_014635 ENOG4105UFD tol-pal system protein YbgF FFE93_014640 ENOG4105KCK Peptidoglycan-associated lipoprotein FFE93_014645 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FFE93_014650 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FFE93_014650 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FFE93_014655 ENOG4105M8F Biopolymer transport protein exbD tolR FFE93_014660 ENOG4105E02 MotA TolQ exbB proton channel FFE93_014665 ENOG4107YD3 Thioesterase FFE93_014670 ENOG4105KJB cyd operon protein YbgE FFE93_014680 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FFE93_014685 ENOG4105C4M (Ubiquinol oxidase) subunit I FFE93_014690 ENOG4105CGH 5'-nucleotidase FFE93_014695 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FFE93_014700 ENOG4105CMV Succinyl-CoA synthetase subunit beta FFE93_014705 ENOG4105C7S Dehydrogenase FFE93_014710 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FFE93_014715 ENOG4105E33 succinate dehydrogenase FFE93_014725 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FFE93_014730 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FFE93_014735 ENOG4105BZN citrate synthase FFE93_014760 ENOG4105E7W lamb ycsf family protein FFE93_014765 ENOG4107R7A Allophanate hydrolase subunit 2 FFE93_014770 ENOG4105P4J Allophanate hydrolase, subunit 1 FFE93_014775 ENOG4107QNR UPF0135 protein FFE93_014780 ENOG4107RF4 Phosphodiesterase FFE93_014785 ENOG4105CVP deoxyribo-dipyrimidine photolyase FFE93_014790 ENOG4107SEY Conserved Protein FFE93_014795 ENOG4105XIQ Protein of unknown function (DUF2517) FFE93_014805 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FFE93_014810 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FFE93_014815 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FFE93_014820 ENOG4105C08 Histidine kinase FFE93_014825 ENOG4105EEX Two component transcriptional regulator (Winged helix family FFE93_014845 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FFE93_014855 ENOG4105EV9 Alpha Beta Hydrolase FFE93_014860 ENOG4105NNH LexA regulated protein FFE93_014865 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_014870 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FFE93_014875 ENOG41090R7 Ferric uptake FFE93_014885 ENOG4105GX6 (LipO)protein FFE93_014895 ENOG4105CX6 glutaminyL-tRNA synthetase FFE93_014900 ENOG4105CI1 PTS System FFE93_014910 ENOG4105CE4 GlcNAc 6-P deacetylase FFE93_014915 ENOG4105E2R ROK family FFE93_014920 ENOG4105D4U had-superfamily hydrolase, subfamily iia FFE93_014925 ENOG4105CAQ asparagine synthetase FFE93_014960 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FFE93_014965 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FFE93_014970 ENOG4105C9A Phoh family FFE93_014975 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FFE93_014980 ENOG4108JU5 Magnesium and cobalt efflux protein FFE93_014985 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FFE93_015000 ENOG4107RP9 extracellular solute-binding protein, family 3 FFE93_015005 ENOG4105EAD ABC transporter FFE93_015010 ENOG4105DRP amino acid AbC transporter FFE93_015015 ENOG4105CDA abc transporter atp-binding protein FFE93_015020 ENOG4107PAI alpha helical protein FFE93_015025 ENOG4105C8T Leucyl-tRNA synthetase FFE93_015030 ENOG4108U2H Rare lipoprotein B FFE93_015035 ENOG4105DJF DNA polymerase III, delta' subunit FFE93_015040 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FFE93_015045 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FFE93_015055 ENOG4105CJN penicillin-binding protein FFE93_015060 ENOG4105CNI cell division protein FtsW FFE93_015065 ENOG4105K6T rare lipoprotein A FFE93_015070 ENOG4105DZ1 carboxypeptidase FFE93_015075 ENOG4108Z43 UPF0250 protein FFE93_015080 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FFE93_015085 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FFE93_015090 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FFE93_015095 ENOG4105BZU Histidine kinase FFE93_015100 ENOG4107Z6W Protein CrcB homolog FFE93_015105 ENOG4105VEQ Cold shock protein FFE93_015115 ENOG4108N8T regulatoR FFE93_015125 ENOG4108R1E Serine threonine protein phosphatase 1 FFE93_015140 ENOG4108JJ7 ABC transporter FFE93_015145 ENOG4105EZE Cupin 4 family protein FFE93_015150 ENOG4107TII Recombinase FFE93_015180 ENOG4105UZW Tail fiber assembly protein FFE93_015235 ENOG4105TKZ Tail Sheath FFE93_015335 ENOG4105HRS Antitermination protein FFE93_015400 ENOG4105DFP Integrase FFE93_015410 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FFE93_015415 ENOG4105WQ3 Rna-binding protein FFE93_015420 ENOG4105C8N cysteinyl-tRNA synthetase FFE93_015425 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FFE93_015430 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FFE93_015435 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FFE93_015440 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FFE93_015445 ENOG4105CV6 ABC transporter, permease FFE93_015450 ENOG4108I0Y (ABC) transporter FFE93_015455 ENOG4108UJV acyl-CoA thioesterase i FFE93_015460 ENOG4105E1F short-chain dehydrogenase reductase FFE93_015465 ENOG4107QR8 Thioredoxin FFE93_015470 ENOG4107QX8 SPFH domain, Band 7 family protein FFE93_015475 ENOG4105G5H Membrane FFE93_015480 ENOG4108Z6Z Transcriptional regulator FFE93_015485 ENOG4105C59 p-type ATPase FFE93_015490 ENOG4105MBR gumn family FFE93_015495 ENOG4108Z66 YbaK ebsC protein FFE93_015515 ENOG4105CGH 5'-nucleotidase FFE93_015520 ENOG4105EU0 Major facilitator Superfamily FFE93_015525 ENOG4105CKD glutathione-regulated potassium-efflux system protein FFE93_015530 ENOG4107RE1 Inosine-guanosine kinase FFE93_015535 ENOG4108QY5 Ferric enterobactin transport protein FFE93_015540 ENOG4105CMR udp-glucose 4-epimerase FFE93_015550 ENOG4105DMT epimerase dehydratase FFE93_015590 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FFE93_015595 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FFE93_015600 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FFE93_015605 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FFE93_015615 ENOG4107QMP dna polymerase iii subunits gamma and tau FFE93_015620 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FFE93_015625 ENOG4105WD1 Membrane FFE93_015635 ENOG4106428 Protein of unknown function (DUF2496) FFE93_015640 ENOG4105EGS Mechanosensitive ion channel FFE93_015645 ENOG41090EX DsrE family FFE93_015650 ENOG4108IG5 Transcriptional regulator FFE93_015655 ENOG4105C1P efflux transporter, rnd family, mfp subunit FFE93_015660 ENOG4105BZS acriflavin resistance protein FFE93_015665 ENOG4105RMW regulation of transcription, DNA-dependent FFE93_015670 ENOG4108626 Racemase FFE93_015675 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FFE93_015680 ENOG4105NRA 50s ribosomal protein l31 type b FFE93_015685 ENOG4105YK5 50S ribosomal protein L36 FFE93_015690 ENOG4105DSE periplasmic solute binding protein FFE93_015695 ENOG4105CC5 ABC transporter FFE93_015700 ENOG4105DIK (ABC) transporter FFE93_015710 ENOG4108UKR Biofilm formation regulator YbaJ FFE93_015715 ENOG4105KF5 hemolysin expression-modulating protein FFE93_015725 ENOG41080UX Methyltransferase FFE93_015730 ENOG4108MNP Glycoprotein polysaccharide metabolism FFE93_015735 ENOG4105C29 acyl-CoA thioesterase FFE93_015740 ENOG4105BZU Histidine kinase FFE93_015745 ENOG4108YZA Nitrogen regulatory protein pii FFE93_015750 ENOG4105BZ1 (ABC) transporter FFE93_015755 ENOG4105BZ1 (ABC) transporter FFE93_015760 ENOG4108XM1 transcriptional regulator AsnC family FFE93_015770 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) FFE93_015775 ENOG4108NFA extracellular solute-binding protein FFE93_015780 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FFE93_015785 ENOG4108TGP Thioesterase superfamily protein FFE93_015790 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FFE93_015795 ENOG4105EIN peptidylprolyl cis-trans isomerase FFE93_015800 ENOG4105K70 DNA-binding protein FFE93_015805 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FFE93_015810 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FFE93_015815 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FFE93_015820 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FFE93_015830 ENOG4105M85 Bola protein FFE93_015835 ENOG4105IEY (LipO)protein FFE93_015840 ENOG4105EYM Major Facilitator superfamily FFE93_015845 ENOG4108NFH Sugar hydrolase FFE93_015850 ENOG4105E2S oxidase) subunit II FFE93_015855 ENOG4105BZ9 Cytochrome C oxidase, subunit I FFE93_015860 ENOG4105CCU oxidase (Subunit III) FFE93_015865 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FFE93_015870 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FFE93_015875 ENOG4107RDB Major Facilitator FFE93_015880 ENOG4108VPT UPF0234 protein FFE93_015885 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FFE93_015890 ENOG4107S0N DJ-1 family FFE93_015895 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FFE93_015900 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FFE93_015905 ENOG4105CTB Polyprenyl synthetase FFE93_015910 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FFE93_015915 ENOG4108ZAI phosphatidylglycerophosphatase a FFE93_015920 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FFE93_015930 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FFE93_015935 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FFE93_015940 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FFE93_015950 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FFE93_015955 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FFE93_015960 ENOG4105VIE preprotein translocase, subunit YajC FFE93_015965 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FFE93_016070 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 FFE93_016095 ENOG4105RWQ Protein of unknown function (DUF1364) FFE93_016265 ENOG4108KU3 Integrase FFE93_016270 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FFE93_016275 ENOG4108ZYK Acyl carrier protein phosphodiesterase FFE93_016280 ENOG4105D3R alkyl hydroperoxide reductase FFE93_016285 ENOG41074AV Hok/gef family FFE93_016295 ENOG4105CHR reductase FFE93_016300 ENOG4107R28 alpha amylase, catalytic region FFE93_016305 ENOG4105C85 amino acid FFE93_016310 ENOG4105CWM branched-chain amino acid transport system II carrier protein FFE93_016320 ENOG4105BZU Histidine kinase FFE93_016325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FFE93_016330 ENOG4107RH8 nuclease SbcCD subunit D FFE93_016335 ENOG4105EYH Exonuclease FFE93_016340 ENOG4105DKQ ROK family FFE93_016345 ENOG4105DH7 May be involved in recombination (By similarity) FFE93_016350 ENOG4105NBK UPF0345 protein FFE93_016355 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FFE93_016400 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FFE93_016405 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FFE93_016410 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FFE93_016415 ENOG4105V1F Fermentation respiration switch protein FFE93_016425 ENOG4105CIN aminoacyl-histidine dipeptidase FFE93_016430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FFE93_016445 ENOG4105CJ2 (LipO)protein FFE93_016450 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FFE93_016455 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FFE93_016460 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FFE93_016465 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FFE93_016470 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FFE93_016475 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FFE93_016480 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FFE93_016485 ENOG4105E7A Glutamine amidotransferase FFE93_016495 ENOG4107QPN acyl-Coa dehydrogenase FFE93_016500 ENOG4106YJS accessory processing protein FFE93_016510 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type FFE93_016515 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FFE93_016525 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FFE93_016535 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FFE93_016540 ENOG4105CHM Aminotransferase FFE93_016550 ENOG4105EQ0 Major Facilitator superfamily FFE93_016555 ENOG4108UMN azlc family FFE93_016560 ENOG4105ZED uncharacterized protein ygaH FFE93_016565 ENOG4105NTK Transcriptional repressor Mpra FFE93_016570 ENOG4105CW7 secretion protein, HlyD family FFE93_016575 ENOG4105C0R drug resistance transporter emrb qaca subfamily FFE93_016580 ENOG4105EIB trna rrna methyltransferase FFE93_016585 ENOG4105K63 Thioredoxin FFE93_016590 ENOG4106IUH DTW domain containing protein FFE93_016595 ENOG4105CD5 CoA-binding domain protein FFE93_016600 ENOG4105JIM Phosphatidylserine synthase FFE93_016640 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FFE93_016645 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FFE93_016650 ENOG4105C34 Pseudouridine synthase FFE93_016660 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FFE93_016665 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FFE93_016670 ENOG4105CQC Prephenate dehydratase FFE93_016680 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FFE93_016685 ENOG4108NEV two component transcriptional regulator, LytTR family FFE93_016690 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FFE93_016695 ENOG4108NE3 Salt-induced outer membrane protein FFE93_016700 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FFE93_016710 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FFE93_016720 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FFE93_016725 ENOG4106KVJ cytochrome C assembly protein FFE93_016730 ENOG4108JU6 CBS domain protein FFE93_016735 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FFE93_016740 ENOG4105D9M gamma-glutamylcysteine synthetase FFE93_016745 ENOG4105W39 Membrane FFE93_016750 ENOG4107VXZ Hydrolase FFE93_016785 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FFE93_016790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FFE93_016795 ENOG4105Y3E Modulates RecA activity (By similarity) FFE93_016800 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FFE93_016825 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FFE93_016830 ENOG4108IUS Transketolase FFE93_016835 ENOG4108HHA Transketolase FFE93_016840 ENOG4105CNN ABC, transporter FFE93_016845 ENOG4105C2J ABC transporter FFE93_016855 ENOG4105ETE Transcriptional regulator (LacI family FFE93_016870 ENOG4108NEM leader-binding protein dmsD FFE93_016875 ENOG4107KGK dmso reductase anchor subunit FFE93_016880 ENOG4105QAX Iron-sulfur FFE93_016885 ENOG4107QY8 reductase FFE93_016890 ENOG4105C0A alcohol dehydrogenase FFE93_016895 ENOG4107W7X Aldolase FFE93_016900 ENOG4105EDR glucose galactose transporter FFE93_016910 ENOG4105CMG Carbohydrate kinase FFE93_016920 ENOG4107EDW L-fucose operon activator FFE93_016925 ENOG4107GFK fumarate FFE93_016930 ENOG4105YVS arsR family transcriptional regulator FFE93_016935 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FFE93_016950 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FFE93_016955 ENOG4108JEH abc transporter atp-binding protein FFE93_016965 ENOG4105E5Q amino acid AbC transporter FFE93_016970 ENOG4105EAB amino acid AbC transporter FFE93_016985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FFE93_016990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FFE93_016995 ENOG4105DEF Extracellular solute-binding protein, family 5 FFE93_017000 ENOG4105CXK mandelate racemase muconate lactonizing FFE93_017005 ENOG4105CHR reductase FFE93_017020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FFE93_017025 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FFE93_017030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FFE93_017035 ENOG4105DJY efflux transporter, rnd family, mfp subunit FFE93_017040 ENOG4108JJA ABC, transporter FFE93_017070 ENOG4105UGQ Fimbrial FFE93_017080 ENOG4108FZ9 Chaperone FFE93_017085 ENOG4106PG1 outer membrane usher protein FFE93_017090 ENOG4108RQP Major type 1 subunit fimbrin FFE93_017110 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FFE93_017115 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FFE93_017120 ENOG4108K5P (LipO)protein FFE93_017125 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FFE93_017130 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FFE93_017135 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FFE93_017140 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FFE93_017150 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FFE93_017155 ENOG4105DKT Transcriptional regulator FFE93_017160 ENOG4108UTZ Dihydroxyacetone kinase FFE93_017165 ENOG4105CMT Dihydroxyacetone kinase FFE93_017170 ENOG4105CHR reductase FFE93_017175 ENOG4105IE8 Alpha-ketoglutarate permease FFE93_017180 ENOG4105CPQ Dehydrogenase FFE93_017185 ENOG4108YZG isomerase FFE93_017190 ENOG4105N0Z inner membrane protein ygbE FFE93_017195 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FFE93_017200 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FFE93_017205 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FFE93_017210 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FFE93_017215 ENOG4108MXK alkaline phosphatase isozyme conversion FFE93_017220 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FFE93_017225 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FFE93_017230 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FFE93_017235 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FFE93_017240 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FFE93_017255 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FFE93_017260 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FFE93_017265 ENOG4105DXN mazG family FFE93_017270 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FFE93_017275 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FFE93_017280 ENOG4105BZU Histidine kinase FFE93_017285 ENOG4105C0H protease FFE93_017290 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FFE93_017295 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FFE93_017305 ENOG4105EN6 Membrane FFE93_017315 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FFE93_017325 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FFE93_017335 ENOG4105S6R Iron-hydroxamate transporter permease subunit FFE93_017340 ENOG4105J76 Periplasmic binding protein FFE93_017345 ENOG4105E0A ABC, transporter FFE93_017350 ENOG4105BZ4 penicillin-binding protein FFE93_017355 ENOG4105CQ7 ATP-dependent helicase FFE93_017360 ENOG4107XID 2'-5' rna ligase FFE93_017365 ENOG4105PW4 Sugar fermentation stimulation protein homolog FFE93_017370 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FFE93_017375 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FFE93_017380 ENOG4105DJ0 Poly(A) Polymerase FFE93_017385 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FFE93_017390 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FFE93_017395 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FFE93_017400 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FFE93_017405 ENOG4107BJW polysaccharide deacetylase FFE93_017410 ENOG4105E3A (ABC) transporter FFE93_017415 ENOG4105DA5 (ABC) transporter FFE93_017420 ENOG41077A9 carbonic anhydrase FFE93_017425 ENOG4108UGV hypoxanthine phosphoribosyltransferase FFE93_017430 ENOG4105E3B Multicopper oxidase FFE93_017435 ENOG4108ZRK uncharacterized protein yacC FFE93_017440 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FFE93_017505 ENOG4108ZIG UPF0231 protein FFE93_017510 ENOG4107QIJ Aconitate hydratase 2 FFE93_017515 ENOG4107RNH Outer membrane receptor FepA FFE93_017525 ENOG4107QN2 dihydrolipoyl dehydrogenase FFE93_017530 ENOG4107QSN dihydrolipoamide acetyltransferase FFE93_017535 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FFE93_017545 ENOG41073TP transcriptional regulator FFE93_017550 ENOG4105C85 amino acid FFE93_017555 ENOG4106A72 regulatory protein AmpE FFE93_017560 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FFE93_017565 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FFE93_017570 ENOG4108ZUW Major pilin subunit FFE93_017575 ENOG4107QHF type ii secretion system protein e FFE93_017580 ENOG4105D7Q type ii secretion system FFE93_017585 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FFE93_017595 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FFE93_017605 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FFE93_017610 ENOG4105M6F mutator MutT protein FFE93_017620 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FFE93_017635 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FFE93_017640 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FFE93_017645 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FFE93_017655 ENOG4105DFU Cell wall formation (By similarity) FFE93_017660 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FFE93_017665 ENOG4105CNI cell division protein FtsW FFE93_017675 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FFE93_017680 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FFE93_017685 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FFE93_017690 ENOG4105CJN penicillin-binding protein FFE93_017695 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FFE93_017700 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FFE93_017715 ENOG4107B7Y DNA-binding transcriptional regulator FruR FFE93_017720 ENOG4108ZP8 Acetolactate synthase small subunit FFE93_017725 ENOG4105C7K acetolactate synthase FFE93_017730 ENOG4108IQE Amp-dependent synthetase and ligase FFE93_017735 ENOG41064T2 transcriptional regulator, lysR family FFE93_017750 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FFE93_017755 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FFE93_017765 ENOG4105S8Q sugar efflux transporter FFE93_017770 ENOG4105C6N Formate acetyltransferase FFE93_017775 ENOG4105F1A Pyruvate formate-lyase FFE93_017780 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FFE93_017785 ENOG4105DP9 ABC transporter FFE93_017790 ENOG4106SMU thiamine transporter membrane protein FFE93_017800 ENOG4108KF1 Membrane FFE93_017805 ENOG4105CQ2 DNA polymerase FFE93_017815 ENOG4105D3G Pseudouridine synthase FFE93_017825 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FFE93_017830 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FFE93_017835 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FFE93_017845 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FFE93_017850 ENOG4105NWN ApaG protein FFE93_017855 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FFE93_017860 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FFE93_017870 ENOG4105DWK Membrane FFE93_017875 ENOG4105N14 lysine exporter protein LysE YggA FFE93_017880 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FFE93_017885 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FFE93_017890 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FFE93_017895 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FFE93_017900 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FFE93_017905 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FFE93_017910 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FFE93_017915 ENOG4105DTN riboflavin biosynthesis protein ribF FFE93_017935 ENOG41063Z6 transcriptional regulator, lysR family FFE93_017940 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FFE93_017945 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FFE93_017955 ENOG4106HK8 GPR1 FUN34 yaaH family protein FFE93_017965 ENOG4105CSH Transporter FFE93_017970 ENOG4108RIR Molybdenum cofactor biosynthesis protein FFE93_017975 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FFE93_017985 ENOG4105D1Q UPF0246 protein FFE93_017995 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FFE93_018010 ENOG41065U4 response regulator FFE93_018015 ENOG4108RH0 Crea protein FFE93_018020 ENOG4105UEI Transcriptional Regulator AraC Family FFE93_018030 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FFE93_018035 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FFE93_018040 ENOG4107SC1 transglycosylase FFE93_018055 ENOG4108KHX Diguanylate cyclase FFE93_018060 ENOG41090EK ompa motb domain protein FFE93_018065 ENOG4105C5H ABC transporter FFE93_018075 ENOG4105CC0 LysR family Transcriptional regulator FFE93_018080 ENOG4105CIS alcohol dehydrogenase FFE93_018085 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FFE93_018090 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FFE93_018095 ENOG4105EAC phosphoserine phosphatase FFE93_018100 ENOG41062Z9 Membrane FFE93_018105 ENOG4105EUP HipA domain protein FFE93_018115 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FFE93_018120 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FFE93_018125 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FFE93_018130 ENOG4105D9N nucleoside FFE93_018135 ENOG4105EYA deoxyribonuclease FFE93_018140 ENOG4108NRW Phospholipase, patatin family FFE93_018150 ENOG4105K3G Periplasmic Protein FFE93_018155 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FFE93_018160 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FFE93_018165 ENOG4108WPU DNA polymerase III subunit psi FFE93_018185 ENOG4105CPC Aldo Keto reductase FFE93_018210 ENOG4105YBH Protein of unknown function (DUF1435) FFE93_018215 ENOG4105BZU Histidine kinase FFE93_018225 ENOG4105D7K pfkb domain protein FFE93_018245 ENOG4105WBN Transcriptional regulator (LacI family FFE93_018250 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FFE93_018285 ENOG4105VDH Dihydroxyacetone kinase FFE93_018290 ENOG4108UTZ Dihydroxyacetone kinase FFE93_018295 ENOG4105CMT Dihydroxyacetone kinase FFE93_018305 ENOG4105BZS acriflavin resistance protein FFE93_018310 ENOG410624X efflux transporter, rnd family, mfp subunit FFE93_018320 ENOG4105CEU Arginine dihydrolase FFE93_018325 ENOG4105D5Q Arginine ornithine antiporter FFE93_018335 ENOG4105DKP glycosyl transferase, family 9 FFE93_018340 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FFE93_018345 ENOG4105DKT Transcriptional regulator FFE93_018355 ENOG4105C2J ABC transporter FFE93_018360 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FFE93_018365 ENOG4105F5R ABC transporter FFE93_018370 ENOG4105D4B ABC, transporter FFE93_018375 ENOG41061GT Aldolase FFE93_018385 ENOG4105RI1 glycoprotein receptor FFE93_018410 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FFE93_018415 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FFE93_018425 ENOG4106549 Antirestriction protein FFE93_018430 ENOG4106H6R UPF0380 protein FFE93_018520 ENOG41083J0 (ABC) transporter FFE93_018550 ENOG4108K5H permease YjgP YjgQ family protein FFE93_018555 ENOG4108M8S permease YjgP YjgQ family protein FFE93_018560 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FFE93_018565 ENOG4105MYG DNA polymerase iii, chi subunit FFE93_018575 ENOG4108MJ3 acetyltransferase FFE93_018580 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FFE93_018590 ENOG4105XEP YhcH YjgK YiaL family protein FFE93_018600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FFE93_018605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FFE93_018610 ENOG4105C3U ABC transporter FFE93_018615 ENOG4108JQ7 (ABC) transporter FFE93_018620 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FFE93_018625 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FFE93_018640 ENOG4107RJJ Transcriptional regulator FFE93_018645 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FFE93_018650 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FFE93_018655 ENOG4105EKV Phosphonate metabolism protein FFE93_018660 ENOG4105FT8 Phosphonate metabolism FFE93_018665 ENOG4105ENV phosphonate C-P lyase system protein PhnK FFE93_018670 ENOG4105HRV phosphonate c-p lyase system protein phnl FFE93_018675 ENOG4105FD8 phosphonate metabolism protein PhnM FFE93_018680 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FFE93_018685 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FFE93_018690 ENOG4105K4T epimerase FFE93_018695 ENOG4108ZPB UPF0306 protein FFE93_018710 ENOG4105DRS transport system, permease FFE93_018715 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FFE93_018740 ENOG4105CXN decarboxylase FFE93_018745 ENOG4105D5Q Arginine ornithine antiporter FFE93_018750 ENOG41082IR Excinuclease ABC C subunit domain protein FFE93_018755 ENOG4108YYD acetyltransferase FFE93_018760 ENOG4105XPQ lipid carrier protein FFE93_018765 ENOG4105CFP Peptidase U32 FFE93_018770 ENOG4106RZ4 Peptidase U32 FFE93_018775 ENOG4105DEN Luciferase family FFE93_018780 ENOG4105C1J atp-dependent rna helicase FFE93_018795 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FFE93_018805 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FFE93_018810 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FFE93_018820 ENOG4105CHV Transcription elongation factor NusA FFE93_018850 ENOG4105EEI dihydropteroate synthase FFE93_018855 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FFE93_018860 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FFE93_018865 ENOG4105HBR Rna-binding protein FFE93_018870 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FFE93_018875 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FFE93_018890 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FFE93_018895 ENOG4105QYV Membrane FFE93_018910 ENOG4105EAH synthase FFE93_018920 ENOG4105HVQ Regulatory factor of maltose metabolism FFE93_018940 ENOG4105DFU Cell wall formation (By similarity) FFE93_018945 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FFE93_018950 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_018955 ENOG4105F0N pyrophosphate phospho-hydrolase FFE93_018960 ENOG4108ZHD aig2 family FFE93_018965 ENOG4105MA0 exported protein FFE93_018975 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FFE93_018980 ENOG4105C37 (CBS) domain FFE93_018985 ENOG41061GZ Protein of unknown function (DUF1107) FFE93_018990 ENOG4108UUE Transcriptional regulator FFE93_018995 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FFE93_019000 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FFE93_019010 ENOG4108V1T peptidylprolyl cis-trans isomerase FFE93_019015 ENOG4105FHY Opacity-associated protein A FFE93_019025 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FFE93_019030 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FFE93_019040 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FFE93_019050 ENOG4105RID UPF0379 protein yhcN FFE93_019055 ENOG4108MXZ Esterase FFE93_019060 ENOG4105WSB biofilm stress and motility protein A FFE93_019065 ENOG4105CSU acyl-Coa dehydrogenase FFE93_019070 ENOG4105C2N RNA methyltransferase TrmH family group 3 FFE93_019075 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FFE93_019080 ENOG4105KPV Transcriptional regulator FFE93_019085 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FFE93_019095 ENOG4105EPW hflc protein FFE93_019100 ENOG4107QJR hflk protein FFE93_019105 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FFE93_019125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FFE93_019130 ENOG4105K8N protein family UPF0079, ATPase FFE93_019135 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FFE93_019140 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FFE93_019165 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FFE93_019170 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FFE93_019175 ENOG4105DJ4 phosphatidylserine decarboxylase FFE93_019180 ENOG4105EGS Mechanosensitive ion channel FFE93_019200 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FFE93_019205 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FFE93_019215 ENOG4105KPY Small multidrug resistance protein FFE93_019230 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FFE93_019235 ENOG4108ZVF (LipO)protein FFE93_019240 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FFE93_019245 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FFE93_019260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FFE93_019270 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FFE93_019275 ENOG4105BZ8 glutamate synthase FFE93_019280 ENOG4105DJB Major Facilitator Superfamily FFE93_019285 ENOG4105CTX dehydratase FFE93_019290 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FFE93_019295 ENOG4105BZW Glycerate kinase FFE93_019300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FFE93_019305 ENOG4105CNV Aldolase FFE93_019310 ENOG4108SIC Transcriptional regulator FFE93_019325 ENOG4105D1F ATP-binding protein FFE93_019335 ENOG4107EEX Cellulose synthase regulator protein FFE93_019340 ENOG4105EJG cellulose synthase FFE93_019350 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FFE93_019355 ENOG4105D4P Coproporphyrinogen iii oxidase FFE93_019360 ENOG4107F3C Hemin uptake protein FFE93_019365 ENOG4107ENK receptor FFE93_019370 ENOG4106QJH hemin transport protein FFE93_019375 ENOG4107R4I Periplasmic binding protein FFE93_019380 ENOG4105EHG Permease protein FFE93_019385 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FFE93_019390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FFE93_019400 ENOG4105E0K tonB-dependent siderophore receptor FFE93_019405 ENOG4105EGS Mechanosensitive ion channel FFE93_019415 ENOG4107RAN Peptidase, M16 FFE93_019420 ENOG4105CQ0 ABC transporter FFE93_019425 ENOG4105PE1 Receptor FFE93_019430 ENOG4108S3W Anti-feci sigma factor, fecr FFE93_019435 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FFE93_019445 ENOG4105KSU Redox protein FFE93_019450 ENOG41066VF YeeE YedE family protein FFE93_019455 ENOG4108IUF type iii secretion FFE93_019460 ENOG4108TN6 type iii secretion FFE93_019465 ENOG41083GP type iii secretion FFE93_019470 ENOG4108HHI Type III secretion system protein FFE93_019490 ENOG4108JIR Flagellum-specific ATP synthase FFE93_019500 ENOG4106H1D secretion system apparatus protein FFE93_019505 ENOG4105UQF type iii secretion FFE93_019565 ENOG4108SZ7 secretion system effector FFE93_019575 ENOG4105ZQI secreted protein FFE93_019605 ENOG4105BZU Histidine kinase FFE93_019615 ENOG4105CK2 sodium dicarboxylate symporter FFE93_019620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FFE93_019625 ENOG41062QD Membrane FFE93_019630 ENOG4107QN1 sodium solute FFE93_019670 ENOG4108RR8 protoporphyrinogen oxidase FFE93_019675 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FFE93_019690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FFE93_019695 ENOG4105CHU acetyl-coa acetyltransferase FFE93_019700 ENOG4107QK7 reductase FFE93_019705 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FFE93_019710 ENOG4105MDZ Transcriptional activator rfaH FFE93_019715 ENOG4105D52 delta-aminolevulinic acid dehydratase FFE93_019725 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FFE93_019730 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FFE93_019735 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FFE93_019740 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FFE93_019745 ENOG4105JC1 sterol-binding domain protein FFE93_019750 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FFE93_019755 ENOG4105CGY Dna recombination protein FFE93_019760 ENOG4108KF1 Membrane FFE93_019775 ENOG4108I5U Uridine phosphorylase FFE93_019780 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FFE93_019790 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FFE93_019795 ENOG4105DZ2 Transcriptional regulator FFE93_019800 ENOG4105EMK carboxylate amino acid amine transporter FFE93_019805 ENOG4105RK9 auxin efflux carrier FFE93_019810 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FFE93_019815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FFE93_019820 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FFE93_019825 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FFE93_019830 ENOG4105BZ7 extracellular solute-binding protein family 1 FFE93_019870 ENOG4108IV0 ABC, transporter FFE93_019875 ENOG4105C0Z ABC transporter FFE93_019880 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FFE93_019885 ENOG4105C32 Amino acid ABC transporter (Permease) FFE93_019890 ENOG4105CP9 extracellular ligand-binding receptor FFE93_019895 ENOG4105U59 -acetyltransferase FFE93_019905 ENOG4105CRP Part of the ABC transporter FtsEX involved in FFE93_019910 ENOG4105CAK Cell division ATP-binding protein ftsE FFE93_019915 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FFE93_019920 ENOG4106H78 methyltransferase FFE93_019925 ENOG4105MG3 Membrane FFE93_019940 ENOG4107FS9 Membrane FFE93_019950 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FFE93_019955 ENOG4105EX9 Membrane FFE93_019960 ENOG4108W1V Lipoprotein FFE93_019965 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FFE93_019975 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FFE93_019980 ENOG4105CXY transporter FFE93_019985 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FFE93_019990 ENOG4105DQF Hydrolase FFE93_019995 ENOG4108EUD Lysophospholipase FFE93_020005 ENOG4105CCF Lysine exporter protein (Lyse ygga) FFE93_020010 ENOG4105C9U ATP-dependent DNA helicase RecQ FFE93_020015 ENOG4105HDD phospholipase FFE93_020020 ENOG4108VUY thioesterase Superfamily protein FFE93_020025 ENOG4105FR1 rard protein FFE93_020030 ENOG4107QUT magnesium and cobalt transport protein CorA FFE93_020045 ENOG4105EQN UPF0261 protein FFE93_020055 ENOG4105C4R Atp-dependent dna helicase FFE93_020060 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FFE93_020065 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FFE93_020070 ENOG4105CT0 Protein of unknown function, DUF484 FFE93_020075 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FFE93_020080 ENOG4105S7Z (LipO)protein FFE93_020085 ENOG4105XQ6 frataxin-like protein FFE93_020095 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FFE93_020100 ENOG41076E6 Uroporphyrinogen-III Synthase FFE93_020105 ENOG4105ECF c-methyltransferase FFE93_020110 ENOG410601J HemY protein FFE93_020135 ENOG4105C85 amino acid FFE93_020150 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FFE93_020155 ENOG4105EGZ biosynthesis protein FFE93_020160 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FFE93_020165 ENOG4108WJ1 acetyltransferase FFE93_020170 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FFE93_020175 ENOG4105C1B dTDP-glucose 4-6-dehydratase FFE93_020180 ENOG4108IJ1 Dehydrogenase FFE93_020185 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FFE93_020190 ENOG4105SFE lipopolysaccharide biosynthesis protein FFE93_020195 ENOG4105ESV Glycosyl transferase, family 4 FFE93_020205 ENOG4105K63 Thioredoxin FFE93_020215 ENOG4105C9X ppx gppa phosphatase FFE93_020225 ENOG4105C4R Atp-dependent dna helicase FFE93_020230 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FFE93_020240 ENOG4108MQF Chaperone FFE93_020255 ENOG4108VEV chaperone FFE93_020310 ENOG4108MA7 Inherit from COG: YD repeat protein FFE93_020315 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FFE93_020320 ENOG4105EMY transcriptional regulator FFE93_020335 ENOG4105C7B Threonine dehydratase FFE93_020340 ENOG4105C01 Dihydroxy-acid dehydratase FFE93_020345 ENOG4105CM2 brancheD-chain amino acid aminotransferase FFE93_020350 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FFE93_020370 ENOG4105C0P Mg chelatase subunit ChlI FFE93_020375 ENOG4108WFC UPF0438 protein yifE FFE93_020380 ENOG4105CVI Transcriptional regulator FFE93_020385 ENOG41062B0 ABC transporter, permease FFE93_020390 ENOG4107R9N ABC transporter FFE93_020395 ENOG4105C2J ABC transporter FFE93_020400 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FFE93_020440 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FFE93_020450 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FFE93_020455 ENOG4108Y73 Membrane FFE93_020460 ENOG4105EJ2 Transcriptional regulator FFE93_020465 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FFE93_020470 ENOG4105C5Q Transcriptional regulator FFE93_020475 ENOG4105EHV domain protein FFE93_020480 ENOG4107QN2 dihydrolipoyl dehydrogenase FFE93_020490 ENOG4107QZV Type I secretion membrane fusion protein FFE93_020515 ENOG4105CH7 arginosuccinase FFE93_020535 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FFE93_020540 ENOG4105DP0 ferredoxin-NADP reductase FFE93_020545 ENOG4105E5M Multidrug resistance protein D FFE93_020550 ENOG4105CBT Fructose-1,6-bisphosphatase FFE93_020555 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FFE93_020560 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FFE93_020570 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FFE93_020575 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FFE93_020580 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FFE93_020585 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FFE93_020590 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FFE93_020595 ENOG41063M6 Cell Division Protein FFE93_020600 ENOG4105ETE Transcriptional regulator (LacI family FFE93_020605 ENOG4105C25 Primosomal protein n' FFE93_020615 ENOG4105VFB Binds the 23S rRNA (By similarity) FFE93_020620 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FFE93_020625 ENOG4105C28 cystathionine FFE93_020630 ENOG4105CFH Aspartokinase FFE93_020635 ENOG4105SYT Methylenetetrahydrofolate reductase FFE93_020640 ENOG4108VTS Membrane FFE93_020645 ENOG4105EBK exported protein FFE93_020660 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FFE93_020665 ENOG4105EKQ RNA-directed DNA polymerase FFE93_020675 ENOG41076HS cation diffusion facilitator family transporter FFE93_020680 ENOG4105FMW periplasmic FFE93_020685 ENOG4105E3W Two component transcriptional regulator (Winged helix family FFE93_020690 ENOG4105E0F Histidine kinase FFE93_020695 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FFE93_020700 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FFE93_020705 ENOG4105D7W serine acetyltransferase FFE93_020710 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FFE93_020715 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FFE93_020720 ENOG4105VW4 glutaredoxin 3 FFE93_020725 ENOG4107YZP Rhodanese domain protein FFE93_020730 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FFE93_020735 ENOG41063SB peptidase FFE93_020740 ENOG4105PXI polysaccharide deacetylase FFE93_020750 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FFE93_020755 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FFE93_020760 ENOG4105XA0 heptosyltransferase ii FFE93_020765 ENOG4105D16 lipopolysaccharide heptosyltransferase i FFE93_020770 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FFE93_020790 ENOG4105W0E 50S ribosomal protein L33 FFE93_020795 ENOG4105KDC 50s ribosomal protein l28 FFE93_020810 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FFE93_020815 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FFE93_020820 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FFE93_020830 ENOG4108PU9 oligogalacturonate-specific porin FFE93_020835 ENOG4105BZU Histidine kinase FFE93_020840 ENOG4108JQ7 (ABC) transporter FFE93_020845 ENOG4105C3U ABC transporter FFE93_020850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FFE93_020855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FFE93_020860 ENOG4105DEF Extracellular solute-binding protein, family 5 FFE93_020865 ENOG4105CKT filamentous hemagglutinin FFE93_020870 ENOG4105D5K Hemolysin activator protein FFE93_020880 ENOG4105CXY transporter FFE93_020885 ENOG4105BZU Histidine kinase FFE93_020890 ENOG4108KX4 response regulator FFE93_020895 ENOG4105DIJ Phosphoethanolamine transferase FFE93_020900 ENOG4108ZHJ Organic hydroperoxide resistance protein FFE93_020910 ENOG4105C85 amino acid FFE93_020915 ENOG4105C84 Histidine ammonia-lyase FFE93_020920 ENOG4105CGP Urocanate hydratase FFE93_020925 ENOG4105BZU Histidine kinase FFE93_020930 ENOG4105E39 Enoyl-CoA hydratase FFE93_020935 ENOG4105D9N nucleoside FFE93_020945 ENOG4105EN6 Membrane FFE93_020950 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) FFE93_020965 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FFE93_020970 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FFE93_020975 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FFE93_020980 ENOG4105CB5 ATP-dependent DNA helicase recG FFE93_020985 ENOG4105D6U Sodium Glutamate Symporter FFE93_020990 ENOG4105C2W permease FFE93_020995 ENOG4105JV1 AsmA family FFE93_021030 ENOG4105HVQ Regulatory factor of maltose metabolism FFE93_021045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FFE93_021050 ENOG4105SUU thioesterase domain FFE93_021055 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FFE93_021060 ENOG4107S2Z UPF0761 membrane protein FFE93_021065 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FFE93_021075 ENOG4105C5F glutamine synthetase FFE93_021080 ENOG4105CUX Signal transduction histidine kinase FFE93_021085 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FFE93_021090 ENOG4105D4P Coproporphyrinogen iii oxidase FFE93_021100 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FFE93_021110 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FFE93_021115 ENOG4105C2M dna polymerase I FFE93_021120 ENOG4108Z33 Thiol disulfide Interchange Protein FFE93_021125 ENOG4105E27 serine threonine protein kinase FFE93_021130 ENOG4105PC1 Conserved Protein FFE93_021140 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FFE93_021170 ENOG4107EJG GntR family transcriptional regulator FFE93_021175 ENOG4105C0R drug resistance transporter emrb qaca subfamily FFE93_021180 ENOG4105ETE Transcriptional regulator (LacI family FFE93_021185 ENOG4108RVA ribokinase FFE93_021190 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FFE93_021195 ENOG4105CNN ABC, transporter FFE93_021200 ENOG4105C2J ABC transporter FFE93_021205 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FFE93_021215 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) FFE93_021220 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FFE93_021230 ENOG4105CU9 asparagine synthetase A FFE93_021235 ENOG4108VVK transcriptional Regulator, AsnC FFE93_021240 ENOG4105QTB Flavodoxin FFE93_021245 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FFE93_021250 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FFE93_021255 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FFE93_021260 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FFE93_021265 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FFE93_021270 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FFE93_021275 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FFE93_021280 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FFE93_021285 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FFE93_021290 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FFE93_021295 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FFE93_021300 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FFE93_021305 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FFE93_021310 ENOG4105CHH sulfate transporter FFE93_021315 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FFE93_021320 ENOG4105C8U phosphate abc transporter FFE93_021325 ENOG4105E2Z phosphate ABC transporter (Permease FFE93_021345 ENOG4106PMH Extracellular solute-binding protein family 3 FFE93_021350 ENOG4105EAD ABC transporter FFE93_021355 ENOG4105DRP amino acid AbC transporter FFE93_021360 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FFE93_021365 ENOG4105C7N Xanthine uracil vitamin C permease FFE93_021380 ENOG4105BZU Histidine kinase FFE93_021385 ENOG4108YYH Nadph-dependent fmn reductase FFE93_021390 ENOG4105C8Q Methyl-accepting chemotaxis FFE93_021395 ENOG4108UMI ABC transporter, permease FFE93_021400 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FFE93_021410 ENOG4105RKW reductase (By FFE93_021415 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FFE93_021420 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FFE93_021430 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FFE93_021435 ENOG4105VG0 50S ribosomal protein l34