locus-tag	class	description
J5M86_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5M86_00010	COG0592	DNA-directed DNA polymerase activity
J5M86_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J5M86_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5M86_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
J5M86_00060	COG0187	DNA topoisomerase II activity
J5M86_00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5M86_00070	COG3266	domain, Protein
J5M86_00100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5M86_00130	COG0151	Belongs to the GarS family
J5M86_00170	COG0515	serine threonine protein kinase
J5M86_00175	COG0515	serine threonine protein kinase
J5M86_00180	COG0768	penicillin binding
J5M86_00195	COG1716	ATPase activity
J5M86_00235	COG1609	Transcriptional regulator
J5M86_00245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5M86_00250	COG0765	amino acid transport
J5M86_00260	COG0673	inositol 2-dehydrogenase activity
J5M86_00280	COG0789	Transcriptional regulator
J5M86_00300	COG2326	polyphosphate kinase activity
J5M86_00305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J5M86_00310	COG1074	ATP-dependent DNA helicase activity
J5M86_00315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5M86_00390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5M86_00405	COG0243	molybdopterin cofactor binding
J5M86_00405	COG3383	formate dehydrogenase (NAD+) activity
J5M86_00410	COG0243	molybdopterin cofactor binding
J5M86_00410	COG3383	formate dehydrogenase (NAD+) activity
J5M86_00415	COG0437	4 iron, 4 sulfur cluster binding
J5M86_00425	COG0709	Synthesizes selenophosphate from selenide and ATP
J5M86_00480	COG1869	D-ribose catabolic process
J5M86_00485	COG0513	Belongs to the DEAD box helicase family
J5M86_00495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5M86_00510	COG3012	SEC-C Motif Domain Protein
J5M86_00580	COG1764	response to oxidative stress
J5M86_00595	COG1414	Transcriptional regulator
J5M86_00605	COG0477	Major facilitator Superfamily
J5M86_00610	COG2186	Transcriptional regulator
J5M86_00615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5M86_00650	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_00655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J5M86_00660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5M86_00665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J5M86_00670	COG2130	NADP-dependent
J5M86_00675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J5M86_00680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5M86_00680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5M86_00695	COG1113	amino acid transport
J5M86_00760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5M86_00765	COG0730	response to heat
J5M86_00770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5M86_00780	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
J5M86_00785	COG3415	Transposase
J5M86_00785	COG2801	Transposase and inactivated derivatives
J5M86_00810	COG0018	arginyl-trna synthetase
J5M86_00835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5M86_00860	COG0494	nUDIX hydrolase
J5M86_00865	COG1950	PFAM Membrane protein of
J5M86_00870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5M86_00880	COG0022	dehydrogenase e1 component
J5M86_00885	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5M86_00895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J5M86_00920	COG0477	Major facilitator Superfamily
J5M86_00960	COG1960	acyl-CoA dehydrogenase activity
J5M86_00975	COG1881	PFAM PEBP family protein
J5M86_00990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5M86_00990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5M86_01005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J5M86_01015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J5M86_01030	COG0717	Belongs to the dCTP deaminase family
J5M86_01040	COG0517	IMP dehydrogenase activity
J5M86_01040	COG1125	glycine betaine transport
J5M86_01045	COG1174	glycine betaine transport
J5M86_01050	COG1174	glycine betaine transport
J5M86_01085	COG2181	nitrate reductase activity
J5M86_01085	COG0247	lactate metabolic process
J5M86_01095	COG1045	serine acetyltransferase
J5M86_01100	COG0776	regulation of translation
J5M86_01145	COG1595	DNA-templated transcription, initiation
J5M86_01160	COG4552	Acetyltransferase involved in intracellular survival and related
J5M86_01170	COG1278	Cold shock
J5M86_01175	COG0768	penicillin binding
J5M86_01180	COG1316	TRANSCRIPTIONal
J5M86_01195	COG2205	protein histidine kinase activity
J5M86_01200	COG0745	RESPONSE REGULATOR receiver
J5M86_01205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J5M86_01210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J5M86_01215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5M86_01220	COG1120	ATPase activity
J5M86_01225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5M86_01230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5M86_01235	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J5M86_01250	COG1595	DNA-templated transcription, initiation
J5M86_01255	COG0598	Magnesium transport protein CorA
J5M86_01260	COG0114	fumarate hydratase activity
J5M86_01270	COG1305	Transglutaminase-like
J5M86_01290	COG1131	(ABC) transporter
J5M86_01305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5M86_01310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5M86_01335	COG2197	response regulator
J5M86_01345	COG4585	Histidine kinase
J5M86_01390	COG0582	viral genome integration into host DNA
J5M86_01405	COG0242	peptide deformylase activity
J5M86_01435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J5M86_01450	COG2072	flavoprotein involved in K transport
J5M86_01460	COG4214	carbohydrate transport
J5M86_01465	COG1129	ABC transporter
J5M86_01470	COG4213	ABC transporter substrate-binding protein
J5M86_01480	COG2115	Belongs to the xylose isomerase family
J5M86_01485	COG1070	Carbohydrate kinase
J5M86_01490	COG2154	pterin-4-alpha-carbinolamine dehydratase
J5M86_01530	COG0433	COG0433 Predicted ATPase
J5M86_01560	COG0204	Acyl-transferase
J5M86_01560	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_01570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5M86_01590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5M86_01595	COG1126	abc transporter atp-binding protein
J5M86_01600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5M86_01605	COG0765	amino acid transport
J5M86_01610	COG0765	amino acid transport
J5M86_01630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J5M86_01645	COG0531	amino acid
J5M86_01655	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5M86_01660	COG0577	efflux transmembrane transporter activity
J5M86_01660	COG1136	(ABC) transporter
J5M86_01665	COG1320	monovalent cation:proton antiporter activity
J5M86_01675	COG1863	multisubunit Na H antiporter MnhE subunit
J5M86_01680	COG0651	ATP synthesis coupled electron transport
J5M86_01685	COG1006	Multisubunit Na H antiporter MnhC subunit
J5M86_01690	COG2111	Na H antiporter
J5M86_01690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5M86_01695	COG0765	amino acid transport
J5M86_01700	COG1126	abc transporter atp-binding protein
J5M86_01710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
J5M86_01725	COG2124	cytochrome p450
J5M86_01740	COG1233	COG1233 Phytoene dehydrogenase and related
J5M86_01750	COG0142	geranyltranstransferase activity
J5M86_01765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J5M86_01770	COG1297	OPT oligopeptide transporter protein
J5M86_01780	COG2066	Belongs to the glutaminase family
J5M86_01800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J5M86_01815	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J5M86_01840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5M86_01865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5M86_01875	COG0251	oxidation-reduction process
J5M86_01900	COG0494	nUDIX hydrolase
J5M86_01910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5M86_01955	COG1111	helicase
J5M86_01955	COG1205	dead DEAH box helicase
J5M86_01960	COG1366	Belongs to the anti-sigma-factor antagonist family
J5M86_01965	COG2890	protein-(glutamine-N5) methyltransferase activity
J5M86_01970	COG1754	DNA topoisomerase type I activity
J5M86_01970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5M86_01990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5M86_01995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5M86_02005	COG0546	phosphoglycolate phosphatase activity
J5M86_02020	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5M86_02030	COG1937	Protein conserved in bacteria
J5M86_02035	COG0596	Alpha beta hydrolase
J5M86_02055	COG0037	tRNA processing
J5M86_02060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J5M86_02065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5M86_02070	COG0302	gtp cyclohydrolase
J5M86_02080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5M86_02100	COG2197	response regulator
J5M86_02105	COG4585	Histidine kinase
J5M86_02110	COG0649	NAD binding
J5M86_02140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
J5M86_02155	COG3285	dna ligase
J5M86_02155	COG1793	dna ligase
J5M86_02160	COG3285	dna ligase
J5M86_02160	COG1793	dna ligase
J5M86_02165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J5M86_02170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5M86_02190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J5M86_02205	COG4555	ABC transporter
J5M86_02245	COG3842	ATPase activity
J5M86_02255	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J5M86_02275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5M86_02285	COG0248	Ppx GppA phosphatase
J5M86_02290	COG1082	Xylose isomerase domain protein TIM barrel
J5M86_02295	COG1131	(ABC) transporter
J5M86_02320	COG1305	Transglutaminase-like
J5M86_02325	COG0506	proline dehydrogenase activity
J5M86_02330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J5M86_02340	COG0123	including yeast histone deacetylase and acetoin utilization protein
J5M86_02370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
J5M86_02375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
J5M86_02380	COG0181	hydroxymethylbilane synthase activity
J5M86_02385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J5M86_02385	COG1648	precorrin-2 dehydrogenase activity
J5M86_02390	COG0113	porphobilinogen synthase activity
J5M86_02400	COG1876	peptidase activity
J5M86_02415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5M86_02420	COG0406	alpha-ribazole phosphatase activity
J5M86_02425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5M86_02430	COG0785	Cytochrome C biogenesis protein
J5M86_02440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5M86_02465	COG0483	inositol monophosphate 1-phosphatase activity
J5M86_02475	COG4948	Mandelate Racemase Muconate Lactonizing
J5M86_02490	COG1131	(ABC) transporter
J5M86_02505	COG1278	Cold shock
J5M86_02515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J5M86_02525	COG2197	response regulator
J5M86_02535	COG2252	PERMEase
J5M86_02560	COG1061	Type III restriction enzyme res subunit
J5M86_02570	COG3590	peptidase
J5M86_02590	COG2017	converts alpha-aldose to the beta-anomer
J5M86_02595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J5M86_02615	COG1169	isochorismate synthase
J5M86_02620	COG2226	methyltransferase
J5M86_02635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5M86_02640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5M86_02645	COG0649	NAD binding
J5M86_02655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J5M86_02660	COG1034	ATP synthesis coupled electron transport
J5M86_02665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J5M86_02680	COG0713	ATP synthesis coupled electron transport
J5M86_02685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5M86_02700	COG0142	geranyltranstransferase activity
J5M86_02705	COG3226	Transcriptional regulator
J5M86_02725	COG1024	Enoyl-CoA hydratase
J5M86_02730	COG1013	pyruvate-flavodoxin oxidoreductase activity
J5M86_02735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
J5M86_02735	COG0674	pyruvate-flavodoxin oxidoreductase activity
J5M86_02750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5M86_02755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5M86_02760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5M86_02765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J5M86_02770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5M86_02780	COG0713	ATP synthesis coupled electron transport
J5M86_02785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5M86_02795	COG1007	ATP synthesis coupled electron transport
J5M86_02800	COG0076	glutamate decarboxylase activity
J5M86_02825	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_02840	COG3883	PFAM NLP P60 protein
J5M86_02840	COG0791	NLP P60 protein
J5M86_02850	COG0459	protein refolding
J5M86_02865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5M86_02875	COG2814	Major facilitator Superfamily
J5M86_02885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J5M86_02890	COG0259	pyridoxamine-phosphate oxidase activity
J5M86_02900	COG3103	Sh3 type 3 domain protein
J5M86_02900	COG1388	LysM domain
J5M86_02900	COG0791	NLP P60 protein
J5M86_02905	COG3158	transport of potassium into the cell
J5M86_02930	COG2226	methyltransferase
J5M86_02930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5M86_02930	COG0596	Alpha beta hydrolase
J5M86_02935	COG2267	carboxylic ester hydrolase activity
J5M86_02985	COG1970	mechanosensitive ion channel activity
J5M86_02995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J5M86_03010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J5M86_03015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5M86_03020	COG0303	'Molybdopterin
J5M86_03025	COG0315	cyclic pyranopterin monophosphate synthase activity
J5M86_03045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5M86_03060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J5M86_03095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5M86_03100	COG0084	hydrolase, TatD family'
J5M86_03115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5M86_03120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5M86_03125	COG0488	(ABC) transporter
J5M86_03135	COG4106	trans-aconitate 2-methyltransferase activity
J5M86_03185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5M86_03190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5M86_03195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5M86_03200	COG0193	aminoacyl-tRNA hydrolase activity
J5M86_03225	COG0148	phosphopyruvate hydratase activity
J5M86_03265	COG5640	endopeptidase activity
J5M86_03280	COG0183	Belongs to the thiolase family
J5M86_03285	COG2755	lipolytic protein G-D-S-L family
J5M86_03310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J5M86_03310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J5M86_03315	COG0587	DNA-directed DNA polymerase activity
J5M86_03330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
J5M86_03350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5M86_03390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5M86_03400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5M86_03415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5M86_03420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J5M86_03430	COG1072	(Pantothenic acid kinase))
J5M86_03435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5M86_03440	COG0736	holo-[acyl-carrier-protein] synthase activity
J5M86_03455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5M86_03460	COG0596	Alpha beta hydrolase
J5M86_03465	COG0802	atpase or kinase
J5M86_03470	COG1214	PFAM Peptidase M22, glycoprotease
J5M86_03470	COG0456	acetyltransferase
J5M86_03480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5M86_03485	COG1472	Belongs to the glycosyl hydrolase 3 family
J5M86_03500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5M86_03505	COG0459	protein refolding
J5M86_03510	COG1595	DNA-templated transcription, initiation
J5M86_03525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5M86_03535	COG0516	GMP reductase activity
J5M86_03540	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_03565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5M86_03565	COG0519	Catalyzes the synthesis of GMP from XMP
J5M86_03570	COG0477	Major facilitator Superfamily
J5M86_03585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5M86_03595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5M86_03605	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_03635	COG0045	succinate-CoA ligase (ADP-forming) activity
J5M86_03665	COG0138	bifunctional purine biosynthesis protein purh
J5M86_03670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J5M86_03680	COG0039	L-malate dehydrogenase activity
J5M86_03690	COG0538	isocitrate dehydrogenase activity
J5M86_03715	COG0438	transferase activity, transferring glycosyl groups
J5M86_03720	COG0438	transferase activity, transferring glycosyl groups
J5M86_03730	COG0438	transferase activity, transferring glycosyl groups
J5M86_03735	COG0489	protein tyrosine kinase activity
J5M86_03735	COG3206	protein involved in exopolysaccharide biosynthesis
J5M86_03760	COG0438	transferase activity, transferring glycosyl groups
J5M86_03765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5M86_03770	COG0463	Glycosyl transferase, family 2
J5M86_03770	COG1216	Glycosyl transferase, family 2
J5M86_03805	COG0180	Tryptophanyl-tRNA synthetase
J5M86_03820	COG1053	succinate dehydrogenase
J5M86_03825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5M86_03840	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
J5M86_03840	COG0662	Cupin 2, conserved barrel domain protein
J5M86_03845	COG0167	dihydroorotate dehydrogenase activity
J5M86_03860	COG1473	amidohydrolase
J5M86_03860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
J5M86_03865	COG1744	ABC transporter substrate-binding protein PnrA-like
J5M86_03870	COG3845	ABC transporter
J5M86_03875	COG4603	Belongs to the binding-protein-dependent transport system permease family
J5M86_03880	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5M86_03900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5M86_03900	COG0662	Cupin 2, conserved barrel domain protein
J5M86_03905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5M86_03925	COG0714	Associated with various cellular activities
J5M86_03950	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_03955	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_03960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J5M86_03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5M86_03990	COG0427	acetyl-CoA hydrolase
J5M86_04005	COG4770	biotin carboxylase activity
J5M86_04010	COG0656	L-ascorbic acid biosynthetic process
J5M86_04020	COG0515	serine threonine protein kinase
J5M86_04045	COG1960	acyl-CoA dehydrogenase activity
J5M86_04050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5M86_04065	COG0424	maF-like protein
J5M86_04080	COG3845	ABC transporter
J5M86_04110	COG2807	transmembrane transport
J5M86_04115	COG0730	response to heat
J5M86_04125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5M86_04130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
J5M86_04135	COG1024	Enoyl-CoA hydratase
J5M86_04140	COG0745	RESPONSE REGULATOR receiver
J5M86_04145	COG5002	protein histidine kinase activity
J5M86_04145	COG3850	Histidine kinase
J5M86_04160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J5M86_04170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5M86_04180	COG1316	TRANSCRIPTIONal
J5M86_04205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J5M86_04210	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_04220	COG1086	Polysaccharide biosynthesis protein
J5M86_04225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5M86_04230	COG1216	Glycosyl transferase, family 2
J5M86_04235	COG1216	Glycosyl transferase, family 2
J5M86_04250	COG2089	acid synthase
J5M86_04265	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_04270	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_04315	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
J5M86_04315	COG0778	Nitroreductase
J5M86_04320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J5M86_04355	COG2258	MOSC domain
J5M86_04365	COG2835	tetraacyldisaccharide 4'-kinase activity
J5M86_04375	COG1309	transcriptional regulator
J5M86_04380	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_04385	COG1024	Enoyl-CoA hydratase
J5M86_04395	COG0765	amino acid transport
J5M86_04400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5M86_04405	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J5M86_04425	COG3483	tryptophan 2,3-dioxygenase activity
J5M86_04465	COG1140	nitrate reductase beta subunit
J5M86_04500	COG1331	Highly conserved protein containing a thioredoxin domain
J5M86_04505	COG2354	Protein conserved in bacteria
J5M86_04520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J5M86_04525	COG0745	RESPONSE REGULATOR receiver
J5M86_04530	COG5002	protein histidine kinase activity
J5M86_04535	COG5401	PFAM Sporulation and spore germination
J5M86_04540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5M86_04545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5M86_04565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J5M86_04570	COG0653	protein targeting
J5M86_04615	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_04630	COG2902	Dehydrogenase
J5M86_04670	COG0513	Belongs to the DEAD box helicase family
J5M86_04675	COG1678	Uncharacterized ACR, COG1678
J5M86_04710	COG3185	4-Hydroxyphenylpyruvate dioxygenase
J5M86_04730	COG1063	alcohol dehydrogenase
J5M86_04745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
J5M86_04755	COG1335	isochorismatase
J5M86_04765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J5M86_04775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5M86_04800	COG1414	Transcriptional regulator
J5M86_04805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5M86_04810	COG0066	3-isopropylmalate dehydratase activity
J5M86_04815	COG0776	regulation of translation
J5M86_04825	COG1920	GTP binding
J5M86_04835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5M86_04845	COG1280	lysine exporter protein (LysE YggA)
J5M86_04850	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5M86_04870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5M86_04875	COG1461	Dihydroxyacetone kinase
J5M86_04885	COG0742	ribosomal rna small subunit methyltransferase
J5M86_04890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J5M86_04905	COG0571	ribonuclease III activity
J5M86_04910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5M86_04920	COG0339	signal peptide processing
J5M86_04930	COG1196	nuclear chromosome segregation
J5M86_04965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J5M86_04980	COG0596	Alpha beta hydrolase
J5M86_05000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J5M86_05020	COG0228	four-way junction DNA binding
J5M86_05025	COG1837	Belongs to the UPF0109 family
J5M86_05030	COG0738	Major facilitator superfamily
J5M86_05035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J5M86_05040	COG0336	Belongs to the RNA methyltransferase TrmD family
J5M86_05050	COG1595	DNA-templated transcription, initiation
J5M86_05095	COG0335	large ribosomal subunit rRNA binding
J5M86_05100	COG0681	Belongs to the peptidase S26 family
J5M86_05110	COG0681	Belongs to the peptidase S26 family
J5M86_05115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5M86_05135	COG0758	DNA mediated transformation
J5M86_05145	COG4974	Belongs to the 'phage' integrase family
J5M86_05160	COG0052	Belongs to the universal ribosomal protein uS2 family
J5M86_05165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J5M86_05170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5M86_05180	COG0528	UMP kinase activity
J5M86_05185	COG0233	cytoplasmic translational termination
J5M86_05195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J5M86_05210	COG0352	thiamine-phosphate diphosphorylase activity
J5M86_05215	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J5M86_05220	COG0477	Major facilitator Superfamily
J5M86_05230	COG0351	phosphomethylpyrimidine kinase
J5M86_05245	COG3268	Saccharopine dehydrogenase
J5M86_05250	COG1760	l-serine dehydratase
J5M86_05270	COG0640	Transcriptional regulator
J5M86_05275	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_05285	COG3842	ATPase activity
J5M86_05290	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5M86_05295	COG1177	transmembrane transport
J5M86_05345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J5M86_05350	COG0750	zinc metalloprotease
J5M86_05355	COG1619	proteins homologs of microcin C7 resistance protein MccF
J5M86_05360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J5M86_05380	COG0454	-acetyltransferase
J5M86_05380	COG0456	acetyltransferase
J5M86_05385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5M86_05390	COG1960	acyl-CoA dehydrogenase activity
J5M86_05400	COG0442	prolyl-tRNA aminoacylation
J5M86_05425	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
J5M86_05435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5M86_05440	COG0175	sulfate reduction
J5M86_05445	COG0779	Required for maturation of 30S ribosomal subunits
J5M86_05460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5M86_05465	COG0439	Biotin carboxylase
J5M86_05480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5M86_05485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5M86_05495	COG0772	Belongs to the SEDS family
J5M86_05515	COG2814	Major facilitator Superfamily
J5M86_05530	COG1530	ribonuclease E activity
J5M86_05535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J5M86_05540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J5M86_05545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5M86_05555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J5M86_05565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J5M86_05575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J5M86_05580	COG0799	negative regulation of ribosome biogenesis
J5M86_05585	COG0406	alpha-ribazole phosphatase activity
J5M86_05635	COG0488	(ABC) transporter
J5M86_05650	COG1960	acyl-CoA dehydrogenase activity
J5M86_05655	COG1960	acyl-CoA dehydrogenase activity
J5M86_05665	COG0247	lactate metabolic process
J5M86_05670	COG0277	FAD linked oxidase domain protein
J5M86_05675	COG0277	FAD linked oxidase domain protein
J5M86_05680	COG2814	Major facilitator Superfamily
J5M86_05685	COG0481	GTPase activity
J5M86_05690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5M86_05720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J5M86_05725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J5M86_05740	COG1420	regulation of RNA biosynthetic process
J5M86_05745	COG0484	heat shock protein binding
J5M86_05760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5M86_05770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5M86_05790	COG0577	efflux transmembrane transporter activity
J5M86_05790	COG1136	(ABC) transporter
J5M86_05805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5M86_05820	COG0477	Major facilitator Superfamily
J5M86_05835	COG1381	Involved in DNA repair and RecF pathway recombination
J5M86_05840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5M86_05850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5M86_05855	COG1121	(ABC) transporter
J5M86_05860	COG0803	Belongs to the bacterial solute-binding protein 9 family
J5M86_05860	COG3443	Belongs to the bacterial solute-binding protein 9 family
J5M86_05900	COG0358	DNA primase activity
J5M86_05925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5M86_05925	COG2755	lipolytic protein G-D-S-L family
J5M86_05940	COG1233	COG1233 Phytoene dehydrogenase and related
J5M86_05945	COG0783	Belongs to the Dps family
J5M86_05950	COG3835	regulator
J5M86_05980	COG0515	serine threonine protein kinase
J5M86_05995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5M86_06000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5M86_06015	COG0584	glycerophosphoryl diester phosphodiesterase
J5M86_06030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J5M86_06050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J5M86_06075	COG3022	response to hydroperoxide
J5M86_06080	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
J5M86_06090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J5M86_06100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J5M86_06135	COG1064	alcohol dehydrogenase
J5M86_06145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J5M86_06160	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J5M86_06165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J5M86_06170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5M86_06175	COG0131	Imidazoleglycerol-phosphate dehydratase
J5M86_06190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J5M86_06215	COG0604	alcohol dehydrogenase
J5M86_06240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J5M86_06245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5M86_06250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5M86_06255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5M86_06260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5M86_06265	COG0072	phenylalanine-tRNA ligase activity
J5M86_06265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5M86_06270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J5M86_06275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J5M86_06280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5M86_06285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5M86_06290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J5M86_06295	COG1438	arginine binding
J5M86_06300	COG0165	Argininosuccinate lyase
J5M86_06305	COG2094	Belongs to the DNA glycosylase MPG family
J5M86_06310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J5M86_06345	COG0647	UMP catabolic process
J5M86_06370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5M86_06375	COG0497	DNA recombination
J5M86_06395	COG0728	peptidoglycan biosynthetic process
J5M86_06400	COG0297	glycogen (starch) synthase activity
J5M86_06405	COG0504	CTP synthase activity
J5M86_06410	COG0494	nUDIX hydrolase
J5M86_06415	COG0436	Aminotransferase
J5M86_06425	COG0667	Aldo Keto reductase
J5M86_06430	COG0137	argininosuccinate synthase activity
J5M86_06435	COG3012	SEC-C Motif Domain Protein
J5M86_06440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5M86_06470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5M86_06475	COG4166	transmembrane transport
J5M86_06485	COG0444	Belongs to the ABC transporter superfamily
J5M86_06490	COG4608	Belongs to the ABC transporter superfamily
J5M86_06495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5M86_06500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5M86_06505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J5M86_06515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J5M86_06520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J5M86_06525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J5M86_06530	COG0069	glutamate synthase activity
J5M86_06535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J5M86_06540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5M86_06560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J5M86_06565	COG0540	Belongs to the ATCase OTCase family
J5M86_06570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5M86_06575	COG0505	Belongs to the CarA family
J5M86_06580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5M86_06590	COG0167	dihydroorotate dehydrogenase activity
J5M86_06595	COG0284	orotidine-5'-phosphate decarboxylase activity
J5M86_06605	COG0194	GDP metabolic process
J5M86_06610	COG1758	RNA polymerase activity
J5M86_06635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5M86_06645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5M86_06675	COG3201	nicotinamide mononucleotide transporter
J5M86_06680	COG0140	phosphoribosyl-ATP diphosphatase activity
J5M86_06685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J5M86_06700	COG0107	imidazoleglycerol-phosphate synthase activity
J5M86_06715	COG1132	(ABC) transporter
J5M86_06720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J5M86_06740	COG0134	indole-3-glycerol-phosphate synthase activity
J5M86_06745	COG0133	tryptophan synthase activity
J5M86_06760	COG0067	glutamate synthase
J5M86_06760	COG0069	glutamate synthase activity
J5M86_06760	COG0070	glutamate synthase
J5M86_06770	COG0469	pyruvate kinase activity
J5M86_06830	COG2050	protein possibly involved in aromatic compounds catabolism
J5M86_06860	COG0438	transferase activity, transferring glycosyl groups
J5M86_06890	COG2226	methyltransferase
J5M86_06895	COG0539	negative regulation of cytoplasmic translation
J5M86_06905	COG0237	dephospho-CoA kinase activity
J5M86_06905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J5M86_06920	COG0556	nucleotide-excision repair
J5M86_06925	COG2409	Drug exporters of the RND superfamily
J5M86_06930	COG5006	permease, DMT superfamily
J5M86_06935	COG0791	NLP P60 protein
J5M86_06940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5M86_06945	COG3387	PFAM Glycoside hydrolase 15-related
J5M86_06955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5M86_06965	COG0322	excinuclease ABC activity
J5M86_06970	COG1660	Displays ATPase and GTPase activities
J5M86_06980	COG1481	regulation of sporulation
J5M86_06985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J5M86_06990	COG0126	phosphoglycerate kinase activity
J5M86_06995	COG0149	triose-phosphate isomerase activity
J5M86_07000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J5M86_07010	COG0363	glucosamine-6-phosphate deaminase activity
J5M86_07025	COG0166	Belongs to the GPI family
J5M86_07030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J5M86_07040	COG0109	protoheme IX farnesyltransferase activity
J5M86_07080	COG0396	ATPase activity
J5M86_07095	COG2151	metal-sulfur cluster biosynthetic enzyme
J5M86_07105	COG0488	(ABC) transporter
J5M86_07110	COG1132	(ABC) transporter
J5M86_07125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J5M86_07140	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_07145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5M86_07150	COG0189	ligase activity
J5M86_07150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5M86_07155	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5M86_07155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5M86_07160	COG4242	Belongs to the peptidase S51 family
J5M86_07165	COG3830	Belongs to the UPF0237 family
J5M86_07165	COG0560	Phosphoserine phosphatase
J5M86_07175	COG0297	glycogen (starch) synthase activity
J5M86_07185	COG1119	ATPase activity
J5M86_07230	COG0514	ATP-dependent DNA helicase (RecQ)
J5M86_07235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5M86_07245	COG2307	Protein conserved in bacteria
J5M86_07245	COG2308	Evidence 4 Homologs of previously reported genes of
J5M86_07260	COG1793	dna ligase
J5M86_07265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5M86_07280	COG0667	Aldo Keto reductase
J5M86_07285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5M86_07290	COG0588	phosphoglycerate mutase activity
J5M86_07305	COG0215	cysteine-tRNA ligase activity
J5M86_07320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5M86_07345	COG1222	aaa ATPase
J5M86_07360	COG0657	acetylesterase activity
J5M86_07365	COG4122	O-methyltransferase activity
J5M86_07375	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J5M86_07380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J5M86_07390	COG1132	(ABC) transporter
J5M86_07395	COG1115	amino acid carrier protein
J5M86_07400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5M86_07405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
J5M86_07410	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5M86_07430	COG2378	regulation of single-species biofilm formation
J5M86_07440	COG0805	protein transport
J5M86_07455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5M86_07460	COG1522	sequence-specific DNA binding
J5M86_07465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5M86_07475	COG1216	Glycosyl transferase, family 2
J5M86_07480	COG3030	protein affecting phage T7 exclusion by the F plasmid
J5M86_07495	COG0129	dihydroxy-acid dehydratase activity
J5M86_07530	COG1742	UPF0060 membrane protein
J5M86_07540	COG4242	Belongs to the peptidase S51 family
J5M86_07550	COG2337	Toxic component of a toxin-antitoxin (TA) module
J5M86_07595	COG3046	protein related to deoxyribodipyrimidine photolyase
J5M86_07670	COG2132	Multicopper oxidase
J5M86_07680	COG0745	RESPONSE REGULATOR receiver
J5M86_07685	COG2205	protein histidine kinase activity
J5M86_07690	COG2205	protein histidine kinase activity
J5M86_07700	COG2132	Multicopper oxidase
J5M86_07765	COG1051	belongs to the nudix hydrolase family
J5M86_07775	COG2080	2 iron, 2 sulfur cluster binding
J5M86_07780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J5M86_07785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5M86_07840	COG3290	protein histidine kinase activity
J5M86_07855	COG0564	pseudouridine synthase activity
J5M86_07860	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_07865	COG1960	acyl-CoA dehydrogenase activity
J5M86_07870	COG0277	FAD linked oxidase domain protein
J5M86_07875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5M86_07880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5M86_07880	COG2755	lipolytic protein G-D-S-L family
J5M86_07895	COG0009	L-threonylcarbamoyladenylate synthase
J5M86_07900	COG1765	OsmC-like protein
J5M86_07905	COG0406	alpha-ribazole phosphatase activity
J5M86_07915	COG0420	3'-5' exonuclease activity
J5M86_07920	COG0419	ATPase involved in DNA repair
J5M86_07935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5M86_07935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5M86_08000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J5M86_08015	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
J5M86_08020	COG0531	amino acid
J5M86_08025	COG0531	amino acid
J5M86_08035	COG3655	Transcriptional regulator
J5M86_08040	COG1160	GTP binding
J5M86_08050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5M86_08065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J5M86_08070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J5M86_08090	COG0124	histidyl-tRNA synthetase
J5M86_08105	COG1196	nuclear chromosome segregation
J5M86_08110	COG1362	aminopeptidase activity
J5M86_08115	COG2755	lipolytic protein G-D-S-L family
J5M86_08115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5M86_08120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5M86_08125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J5M86_08130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5M86_08135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5M86_08145	COG2255	four-way junction helicase activity
J5M86_08150	COG0632	four-way junction helicase activity
J5M86_08155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J5M86_08160	COG0217	transcriptional regulatory protein
J5M86_08165	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
J5M86_08175	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
J5M86_08185	COG0438	transferase activity, transferring glycosyl groups
J5M86_08195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5M86_08210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J5M86_08225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J5M86_08230	COG1984	allophanate hydrolase subunit 2
J5M86_08240	COG1136	(ABC) transporter
J5M86_08250	COG0415	Belongs to the DNA photolyase family
J5M86_08255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5M86_08270	COG1132	(ABC) transporter
J5M86_08280	COG3265	gluconokinase activity
J5M86_08350	COG2189	Belongs to the N(4) N(6)-methyltransferase family
J5M86_08415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5M86_08420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5M86_08420	COG0512	Glutamine amidotransferase of anthranilate synthase
J5M86_08435	COG1132	(ABC) transporter
J5M86_08475	COG2326	polyphosphate kinase activity
J5M86_08490	COG1793	dna ligase
J5M86_08505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5M86_08510	COG3253	May function as heme-dependent peroxidase
J5M86_08520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5M86_08525	COG2364	Membrane
J5M86_08530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5M86_08545	COG0183	Belongs to the thiolase family
J5M86_08550	COG1024	Enoyl-CoA hydratase
J5M86_08550	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5M86_08555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J5M86_08570	COG0656	L-ascorbic acid biosynthetic process
J5M86_08580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J5M86_08585	COG1027	Aspartate ammonia-lyase
J5M86_08590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J5M86_08600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5M86_08605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5M86_08610	COG0569	domain protein
J5M86_08630	COG0756	dUTP diphosphatase activity
J5M86_08645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J5M86_08655	COG2814	Major facilitator Superfamily
J5M86_08660	COG1435	thymidine kinase activity
J5M86_08685	COG1595	DNA-templated transcription, initiation
J5M86_08690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5M86_08695	COG0778	Nitroreductase
J5M86_08700	COG2376	Dihydroxyacetone kinase
J5M86_08705	COG1461	Dihydroxyacetone kinase
J5M86_08710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5M86_08710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5M86_08710	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
J5M86_08825	COG0142	geranyltranstransferase activity
J5M86_08840	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J5M86_08865	COG1940	carbohydrate kinase activity
J5M86_08870	COG1940	carbohydrate kinase activity
J5M86_08910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J5M86_08920	COG1845	cytochrome c oxidase, subunit III
J5M86_08925	COG2010	Cytochrome c
J5M86_08930	COG0723	plastoquinol--plastocyanin reductase activity
J5M86_08935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J5M86_08955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5M86_08960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J5M86_08965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J5M86_08970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5M86_08995	COG0435	Glutathione S-transferase
J5M86_09010	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_09040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5M86_09045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5M86_09055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5M86_09060	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5M86_09065	COG0515	serine threonine protein kinase
J5M86_09070	COG0673	inositol 2-dehydrogenase activity
J5M86_09075	COG0321	lipoyl(octanoyl) transferase activity
J5M86_09080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5M86_09150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J5M86_09155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J5M86_09160	COG3599	regulation of cell shape
J5M86_09170	COG1799	cell septum assembly
J5M86_09180	COG1496	oxidoreductase activity
J5M86_09185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5M86_09190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5M86_09195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J5M86_09205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5M86_09210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5M86_09215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5M86_09220	COG0768	penicillin binding
J5M86_09230	COG0275	rRNA processing
J5M86_09235	COG2001	Belongs to the MraZ family
J5M86_09240	COG0714	Associated with various cellular activities
J5M86_09250	COG1305	Transglutaminase-like
J5M86_09255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5M86_09260	COG0589	response to stress
J5M86_09265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5M86_09295	COG1643	Atp-dependent helicase
J5M86_09315	COG2733	membrane
J5M86_09325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5M86_09330	COG2124	cytochrome p450
J5M86_09340	COG0306	phosphate transporter
J5M86_09360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5M86_09365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5M86_09375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J5M86_09380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J5M86_09385	COG0583	DNA-binding transcription factor activity
J5M86_09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5M86_09400	COG1307	EDD domain protein, DegV family
J5M86_09405	COG0495	leucyl-tRNA aminoacylation
J5M86_09410	COG0644	oxidoreductase
J5M86_09415	COG0268	Binds directly to 16S ribosomal RNA
J5M86_09440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5M86_09450	COG1120	ATPase activity
J5M86_09455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5M86_09465	COG2813	Specifically methylates the guanine in position
J5M86_09470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5M86_09475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J5M86_09480	COG1254	Belongs to the acylphosphatase family
J5M86_09485	COG1690	Belongs to the RtcB family
J5M86_09495	COG0180	Tryptophanyl-tRNA synthetase
J5M86_09500	COG2814	Major facilitator Superfamily
J5M86_09505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5M86_09525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5M86_09540	COG2957	Belongs to the agmatine deiminase family
J5M86_09545	COG0300	oxidoreductase activity
J5M86_09555	COG1201	RNA secondary structure unwinding
J5M86_09560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5M86_09565	COG1396	sequence-specific DNA binding
J5M86_09570	COG1058	Belongs to the CinA family
J5M86_09570	COG1546	Belongs to the CinA family
J5M86_09580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5M86_09595	COG1674	ftsk spoiiie
J5M86_09600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5M86_09615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J5M86_09620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5M86_09625	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5M86_09640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5M86_09645	COG2151	metal-sulfur cluster biosynthetic enzyme
J5M86_09650	COG3396	Phenylacetate-CoA oxygenase
J5M86_09655	COG3460	Phenylacetate-CoA oxygenase
J5M86_09660	COG3396	Phenylacetate-CoA oxygenase
J5M86_09680	COG2186	Transcriptional regulator
J5M86_09685	COG1620	l-lactate permease
J5M86_09690	COG0247	lactate metabolic process
J5M86_09695	COG1139	Iron-sulfur cluster binding protein
J5M86_09700	COG1556	Lactate utilization protein
J5M86_09710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J5M86_09715	COG0746	molybdenum cofactor guanylyltransferase activity
J5M86_09725	COG0116	Belongs to the methyltransferase superfamily
J5M86_09740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5M86_09745	COG1185	polyribonucleotide nucleotidyltransferase activity
J5M86_09770	COG3845	ABC transporter
J5M86_09790	COG0768	penicillin binding
J5M86_09805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5M86_09815	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J5M86_09820	COG3766	membrane
J5M86_09845	COG0105	UTP biosynthetic process
J5M86_09850	COG1968	undecaprenyl-diphosphatase activity
J5M86_09860	COG0285	dihydrofolate synthase activity
J5M86_09870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5M86_09880	COG0525	valine-tRNA ligase activity
J5M86_09885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5M86_09890	COG0740	serine-type endopeptidase activity
J5M86_09895	COG0740	serine-type endopeptidase activity
J5M86_09900	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5M86_09925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J5M86_09940	COG0668	transmembrane transport
J5M86_09950	COG0366	Alpha amylase catalytic
J5M86_09965	COG1946	Acyl-CoA thioesterase
J5M86_09970	COG0789	Transcriptional regulator
J5M86_10025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5M86_10030	COG2837	iron assimilation
J5M86_10040	COG0672	)-iron permease
J5M86_10055	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J5M86_10065	COG1295	ribonuclease BN
J5M86_10075	COG1063	alcohol dehydrogenase
J5M86_10085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5M86_10105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5M86_10110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J5M86_10120	COG1234	tRNA 3'-trailer cleavage
J5M86_10125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5M86_10130	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5M86_10145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5M86_10150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5M86_10155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5M86_10160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5M86_10165	COG0473	3-isopropylmalate dehydrogenase activity
J5M86_10170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J5M86_10175	COG0440	acetolactate synthase activity
J5M86_10200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5M86_10205	COG0154	amidase activity
J5M86_10210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5M86_10235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5M86_10250	COG0482	sulfurtransferase activity
J5M86_10265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J5M86_10280	COG1024	Enoyl-CoA hydratase
J5M86_10305	COG0058	SHG alpha-glucan phosphorylase activity
J5M86_10310	COG0366	Alpha amylase catalytic
J5M86_10315	COG0366	Alpha amylase catalytic
J5M86_10320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J5M86_10330	COG1595	DNA-templated transcription, initiation
J5M86_10390	COG0183	Belongs to the thiolase family
J5M86_10395	COG0346	lactoylglutathione lyase activity
J5M86_10405	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5M86_10410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
J5M86_10415	COG0405	Gamma-glutamyltransferase
J5M86_10440	COG0367	asparagine synthase
J5M86_10455	COG2233	PERMEase
J5M86_10460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5M86_10465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5M86_10470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J5M86_10475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5M86_10480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J5M86_10485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5M86_10490	COG0356	it plays a direct role in the translocation of protons across the membrane
J5M86_10510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5M86_10515	COG0009	L-threonylcarbamoyladenylate synthase
J5M86_10520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J5M86_10535	COG2890	protein-(glutamine-N5) methyltransferase activity
J5M86_10540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5M86_10545	COG0254	rRNA binding
J5M86_10565	COG0083	homoserine kinase activity
J5M86_10570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J5M86_10575	COG0460	homoserine dehydrogenase
J5M86_10595	COG3275	phosphorelay sensor kinase activity
J5M86_10610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5M86_10620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5M86_10625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5M86_10635	COG1253	flavin adenine dinucleotide binding
J5M86_10650	COG0567	Dehydrogenase, E1 component
J5M86_10650	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5M86_10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5M86_10670	COG0765	amino acid transport
J5M86_10715	COG1595	DNA-templated transcription, initiation
J5M86_10725	COG2135	peptidase activity
J5M86_10730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5M86_10735	COG1162	GTPase activity
J5M86_10745	COG0483	inositol monophosphate 1-phosphatase activity
J5M86_10760	COG0612	Peptidase, M16
J5M86_10770	COG1131	(ABC) transporter
J5M86_10770	COG1716	ATPase activity
J5M86_10770	COG0842	Transport permease protein
J5M86_10775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J5M86_10780	COG2133	pyrroloquinoline quinone binding
J5M86_10790	COG1196	nuclear chromosome segregation
J5M86_10790	COG0739	heme binding
J5M86_10790	COG0741	lytic transglycosylase activity
J5M86_10800	COG2884	Cell division ATP-binding protein ftsE
J5M86_10805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J5M86_10850	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5M86_10850	COG1902	pentaerythritol trinitrate reductase activity
J5M86_10880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J5M86_10920	COG1131	(ABC) transporter
J5M86_10930	COG1309	transcriptional regulator
J5M86_10935	COG1615	UPF0182 protein
J5M86_10945	COG3480	Lon protease (S16) C-terminal proteolytic domain
J5M86_11030	COG2261	transglycosylase associated protein
J5M86_11040	COG0513	Belongs to the DEAD box helicase family
J5M86_11045	COG2197	response regulator
J5M86_11050	COG0613	PHP domain protein
J5M86_11065	COG0006	proline dipeptidase activity
J5M86_11075	COG3226	Transcriptional regulator
J5M86_11085	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_11095	COG2239	Acts as a magnesium transporter
J5M86_11110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5M86_11115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5M86_11125	COG1595	DNA-templated transcription, initiation
J5M86_11145	COG1024	Enoyl-CoA hydratase
J5M86_11165	COG0519	Catalyzes the synthesis of GMP from XMP
J5M86_11175	COG1611	Belongs to the LOG family
J5M86_11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5M86_11210	COG0456	acetyltransferase
J5M86_11210	COG0454	-acetyltransferase
J5M86_11225	COG4585	Histidine kinase
J5M86_11230	COG2197	response regulator
J5M86_11235	COG0247	lactate metabolic process
J5M86_11235	COG0277	FAD linked oxidase domain protein
J5M86_11240	COG2720	vancomycin resistance protein
J5M86_11250	COG1217	gtp-binding protein TYPA
J5M86_11255	COG0747	negative chemotaxis
J5M86_11260	COG0601	transmembrane transport
J5M86_11265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5M86_11270	COG0444	Belongs to the ABC transporter superfamily
J5M86_11275	COG4608	Belongs to the ABC transporter superfamily
J5M86_11295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J5M86_11300	COG1960	acyl-CoA dehydrogenase activity
J5M86_11305	COG1960	acyl-CoA dehydrogenase activity
J5M86_11325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5M86_11330	COG2326	polyphosphate kinase activity
J5M86_11335	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_11340	COG2813	Specifically methylates the guanine in position
J5M86_11385	COG0012	GTP binding
J5M86_11395	COG0477	Major facilitator Superfamily
J5M86_11400	COG1322	Protein conserved in bacteria
J5M86_11415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J5M86_11420	COG1570	exodeoxyribonuclease VII activity
J5M86_11425	COG1722	exodeoxyribonuclease VII activity
J5M86_11435	COG1494	fructose-1,6-bisphosphatase
J5M86_11445	COG1122	ATPase activity
J5M86_11460	COG0310	cobalt ion transport
J5M86_11485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J5M86_11490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
J5M86_11490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
J5M86_11510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5M86_11520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J5M86_11525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J5M86_11540	COG0101	tRNA pseudouridine synthase activity
J5M86_11555	COG0308	aminopeptidase N
J5M86_11560	COG0203	ribosomal protein L17
J5M86_11565	COG0202	RNA polymerase activity
J5M86_11575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J5M86_11580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5M86_11585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5M86_11590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J5M86_11620	COG1674	ftsk spoiiie
J5M86_11660	COG0714	Associated with various cellular activities
J5M86_11710	COG0563	adenylate kinase activity
J5M86_11715	COG1252	NADH dehydrogenase
J5M86_11725	COG0200	Binds to the 23S rRNA
J5M86_11730	COG1841	ribosomal large subunit assembly
J5M86_11735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J5M86_11740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J5M86_11745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J5M86_11750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J5M86_11755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J5M86_11760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J5M86_11765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J5M86_11770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J5M86_11775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5M86_11780	COG0255	Belongs to the universal ribosomal protein uL29 family
J5M86_11785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5M86_11790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5M86_11795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5M86_11800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5M86_11805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5M86_11810	COG0089	rRNA binding
J5M86_11815	COG0088	Forms part of the polypeptide exit tunnel
J5M86_11820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5M86_11825	COG0051	transcription antitermination factor activity, RNA binding
J5M86_11845	COG1131	(ABC) transporter
J5M86_11865	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J5M86_11870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5M86_11880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5M86_11885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J5M86_11890	COG0049	tRNA binding
J5M86_11895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5M86_11915	COG0463	Glycosyl transferase, family 2
J5M86_11955	COG0529	Catalyzes the synthesis of activated sulfate
J5M86_11960	COG0730	response to heat
J5M86_11975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J5M86_11980	COG0085	RNA polymerase activity
J5M86_11990	COG0222	ribosome binding
J5M86_11995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5M86_12005	COG0081	regulation of translation
J5M86_12010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J5M86_12030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5M86_12035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J5M86_12045	COG2030	dehydratase
J5M86_12055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5M86_12075	COG1028	Short-chain dehydrogenase reductase Sdr
J5M86_12105	COG1739	Uncharacterized protein family UPF0029
J5M86_12110	COG2814	Major facilitator Superfamily
J5M86_12120	COG1666	GTP binding
J5M86_12125	COG0833	amino acid
J5M86_12135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J5M86_12140	COG1309	transcriptional regulator
J5M86_12145	COG1960	acyl-CoA dehydrogenase activity
J5M86_12175	COG0737	Belongs to the 5'-nucleotidase family
J5M86_12180	COG0501	Belongs to the peptidase M48B family
J5M86_12185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J5M86_12205	COG0726	polysaccharide deacetylase
J5M86_12215	COG4221	oxidoreductase activity
J5M86_12225	COG1960	acyl-CoA dehydrogenase activity
J5M86_12260	COG2233	PERMEase
J5M86_12265	COG1414	Transcriptional regulator
J5M86_12275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5M86_12310	COG0432	Pfam Uncharacterised protein family UPF0047
J5M86_12330	COG1652	LysM domain
J5M86_12350	COG3833	ABC-type maltose transport systems, permease component
J5M86_12355	COG1175	transmembrane transport
J5M86_12365	COG3842	ATPase activity
J5M86_12400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5M86_12405	COG0215	cysteine-tRNA ligase activity
J5M86_12410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5M86_12430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J5M86_12430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J5M86_12440	COG5002	protein histidine kinase activity
J5M86_12445	COG0745	RESPONSE REGULATOR receiver
J5M86_12450	COG0588	phosphoglycerate mutase activity
J5M86_12460	COG0438	transferase activity, transferring glycosyl groups
J5M86_12485	COG1490	D-aminoacyl-tRNA deacylase activity
J5M86_12505	COG0354	folic acid binding
J5M86_12515	COG4044	May play a role in the intracellular transport of hydrophobic ligands
J5M86_12530	COG0745	RESPONSE REGULATOR receiver
J5M86_12535	COG0456	acetyltransferase
J5M86_12540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J5M86_12565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5M86_12595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5M86_12605	COG0463	Glycosyl transferase, family 2
J5M86_12650	COG1796	DNA polymerase
J5M86_12650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J5M86_12670	COG2372	response to copper ion
J5M86_12680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J5M86_12710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5M86_12720	COG0151	Belongs to the GarS family
J5M86_12735	COG0287	Prephenate dehydrogenase
J5M86_12735	COG1605	Chorismate mutase
J5M86_12740	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
J5M86_12750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5M86_12760	COG4991	sh3 domain protein
J5M86_12765	COG4991	sh3 domain protein
J5M86_12810	COG4941	Belongs to the sigma-70 factor family
J5M86_12820	COG3795	YCII-related domain
J5M86_12835	COG0586	Pfam SNARE associated Golgi protein
J5M86_12845	COG2197	response regulator
J5M86_12855	COG1704	LemA family
J5M86_12870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5M86_12875	COG0300	oxidoreductase activity
J5M86_12890	COG2072	flavoprotein involved in K transport
J5M86_12895	COG0477	Major facilitator Superfamily
J5M86_12910	COG0542	response to heat
J5M86_12935	COG0028	Belongs to the TPP enzyme family
J5M86_12950	COG0789	Transcriptional regulator
J5M86_12955	COG0484	heat shock protein binding
J5M86_12960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5M86_12965	COG0443	Heat shock 70 kDa protein
J5M86_12990	COG2409	Drug exporters of the RND superfamily
J5M86_12995	COG2272	Belongs to the type-B carboxylesterase lipase family
J5M86_13005	COG1349	DNA-binding transcription factor activity
J5M86_13010	COG1105	Belongs to the carbohydrate kinase PfkB family
J5M86_13015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5M86_13015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5M86_13020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5M86_13025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5M86_13040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5M86_13040	COG0047	phosphoribosylformylglycinamidine synthase activity
J5M86_13055	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5M86_13060	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
J5M86_13090	COG2318	DinB family
J5M86_13105	COG0402	S-adenosylhomocysteine deaminase activity
J5M86_13115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5M86_13125	COG3257	ureidoglycine aminohydrolase activity
J5M86_13130	COG1929	Belongs to the glycerate kinase type-1 family
J5M86_13150	COG1794	racemase activity, acting on amino acids and derivatives
J5M86_13155	COG0515	serine threonine protein kinase
J5M86_13180	COG3842	ATPase activity
J5M86_13200	COG1522	sequence-specific DNA binding
J5M86_13215	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5M86_13225	COG1228	amidohydrolase
J5M86_13230	COG0402	S-adenosylhomocysteine deaminase activity
J5M86_13235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5M86_13240	COG0442	prolyl-tRNA aminoacylation
J5M86_13245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J5M86_13250	COG2986	histidine ammonia-lyase
J5M86_13260	COG2826	transposase and inactivated derivatives, IS30 family
J5M86_13270	COG1960	acyl-CoA dehydrogenase activity
J5M86_13275	COG1012	belongs to the aldehyde dehydrogenase family
J5M86_13290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5M86_13295	COG2423	ornithine cyclodeaminase activity
J5M86_13300	COG1126	abc transporter atp-binding protein
J5M86_13305	COG0765	amino acid transport
J5M86_13310	COG0765	amino acid transport
J5M86_13320	COG0583	DNA-binding transcription factor activity
J5M86_13330	COG0577	efflux transmembrane transporter activity
J5M86_13330	COG1136	(ABC) transporter
J5M86_13350	COG1136	(ABC) transporter
J5M86_13360	COG4585	Histidine kinase
J5M86_13395	COG0406	alpha-ribazole phosphatase activity
J5M86_13400	COG2755	lipolytic protein G-D-S-L family
J5M86_13435	COG0693	protein deglycase activity
J5M86_13445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5M86_13460	COG0745	RESPONSE REGULATOR receiver
J5M86_13470	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_13475	COG0488	(ABC) transporter
J5M86_13480	COG3220	belongs to the UPF0276 family
J5M86_13500	COG1793	dna ligase
J5M86_13500	COG3285	dna ligase
J5M86_13535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J5M86_13545	COG4585	Histidine kinase
J5M86_13550	COG2197	response regulator
J5M86_13570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J5M86_13575	COG4604	ABC transporter, ATP-binding protein
J5M86_13580	COG4605	iron ion homeostasis
J5M86_13585	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5M86_13590	COG4607	ABC-type enterochelin transport system periplasmic component
J5M86_13605	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_13625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5M86_13670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5M86_13675	COG0297	glycogen (starch) synthase activity
J5M86_13700	COG1051	belongs to the nudix hydrolase family
J5M86_13755	COG2188	Transcriptional regulator
J5M86_13770	COG3718	enzyme involved in inositol metabolism
J5M86_13780	COG3191	aminopeptidase activity
J5M86_13795	COG1595	DNA-templated transcription, initiation
J5M86_13800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5M86_13800	COG2169	Transcriptional regulator
J5M86_13805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J5M86_13840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J5M86_13840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J5M86_13840	COG1703	isobutyryl-CoA mutase activity
J5M86_13850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5M86_13855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5M86_13870	COG2814	Major facilitator Superfamily
J5M86_13880	COG0189	ligase activity
J5M86_13880	COG0569	domain protein
J5M86_13885	COG0189	ligase activity
J5M86_13885	COG4067	protein conserved in archaea
J5M86_13925	COG1022	Amp-dependent synthetase and ligase
J5M86_13930	COG0183	Belongs to the thiolase family
J5M86_13940	COG2197	response regulator
J5M86_13945	COG1131	(ABC) transporter
J5M86_13975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J5M86_13985	COG0477	Major facilitator Superfamily
J5M86_14000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5M86_14100	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
J5M86_14165	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
J5M86_14180	COG1051	belongs to the nudix hydrolase family
J5M86_14250	COG0739	heme binding
J5M86_14255	COG0741	lytic transglycosylase activity
J5M86_14255	COG0791	NLP P60 protein
J5M86_14265	COG0534	Mate efflux family protein
J5M86_14270	COG0359	binds to the 23S rRNA
J5M86_14275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J5M86_14285	COG0360	Binds together with S18 to 16S ribosomal RNA
J5M86_14295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5M86_14305	COG1260	myo-inositol-1-phosphate synthase
J5M86_14315	COG2267	carboxylic ester hydrolase activity
J5M86_14320	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_14325	COG2353	YceI-like domain
J5M86_14385	COG2409	Drug exporters of the RND superfamily
J5M86_14395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
J5M86_14420	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
J5M86_14430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5M86_14445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5M86_14455	COG1937	Protein conserved in bacteria
J5M86_14465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5M86_14470	COG0561	phosphatase activity
J5M86_14485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5M86_14525	COG5650	phosphatidylinositol metabolic process
J5M86_14565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5M86_14580	COG1132	(ABC) transporter
J5M86_14585	COG4988	ABC transporter
J5M86_14590	COG1294	oxidase, subunit
J5M86_14595	COG1271	oxidase subunit
J5M86_14630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J5M86_14640	COG0667	Aldo Keto reductase
J5M86_14650	COG2211	Major facilitator Superfamily
J5M86_14655	COG0425	Belongs to the sulfur carrier protein TusA family
J5M86_14655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5M86_14680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J5M86_14690	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
J5M86_14720	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J5M86_14725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5M86_14730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5M86_14750	COG0318	PFAM AMP-dependent synthetase and ligase
J5M86_14775	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J5M86_14790	COG2011	ABC-type metal ion transport system permease component
J5M86_14795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5M86_14800	COG1464	Belongs to the NlpA lipoprotein family
J5M86_14880	COG1473	amidohydrolase
J5M86_14915	COG1054	Belongs to the UPF0176 family
J5M86_14980	COG3135	benzoate transporter
J5M86_14995	COG1054	Belongs to the UPF0176 family
J5M86_15015	COG3340	Belongs to the peptidase S51 family
J5M86_15050	COG1082	Xylose isomerase domain protein TIM barrel
J5M86_15055	COG0673	inositol 2-dehydrogenase activity
J5M86_15085	COG1595	DNA-templated transcription, initiation
J5M86_15095	COG0492	ferredoxin-NADP+ reductase activity
J5M86_15100	COG3118	belongs to the thioredoxin family
J5M86_15110	COG1192	Involved in chromosome partitioning
J5M86_15115	COG0357	Ribosomal RNA small subunit methyltransferase G
J5M86_15125	COG0706	membrane insertase activity
J5M86_15135	COG0594	ribonuclease P activity
J5M86_15145	COG1192	Involved in chromosome partitioning
J5M86_15190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5M86_15330	COG0629	single-stranded DNA binding