locus-tag class description HEC60_00020 ENOG4105D5U fad dependent oxidoreductase HEC60_00025 ENOG4105C26 Dehydrogenase HEC60_00030 ENOG4105C85 amino acid HEC60_00035 ENOG4108PVQ transcriptional regulator HEC60_00040 ENOG4105DWY Agmatine deiminase HEC60_00050 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HEC60_00055 ENOG4109066 lysm domain bon superfamily protein HEC60_00060 ENOG4107GFK fumarate HEC60_00080 ENOG4108MRH transcriptional regulatory protein HEC60_00085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEC60_00090 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HEC60_00095 ENOG4105C85 amino acid HEC60_00100 ENOG4105CUY Mechanosensitive ion channel HEC60_00130 ENOG4108RCM Nitroreductase HEC60_00135 ENOG4105MSB protein, conserved in bacteria HEC60_00150 ENOG4105HFT AraC family transcriptional regulator HEC60_00155 ENOG4105DHQ Histidine kinase HEC60_00160 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC60_00170 ENOG4105WQ6 Membrane HEC60_00175 ENOG4108JQ7 (ABC) transporter HEC60_00180 ENOG4105C3U ABC transporter HEC60_00185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC60_00190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC60_00195 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HEC60_00205 ENOG4108TSE Transferase HEC60_00210 ENOG4107RNH Outer membrane receptor FepA HEC60_00215 ENOG4105E93 esterase HEC60_00220 ENOG41085A6 mbth domain-containing protein HEC60_00225 ENOG4105C0W non-ribosomal peptide synthetase HEC60_00230 ENOG4105E0A ABC, transporter HEC60_00235 ENOG4105TVJ transport system, permease HEC60_00240 ENOG4105DQ5 transport system permease protein HEC60_00245 ENOG4105E8G Major facilitator Superfamily HEC60_00250 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HEC60_00255 ENOG4105E4F Isochorismate synthase HEC60_00260 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HEC60_00265 ENOG4105WQI isochorismatase HEC60_00270 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HEC60_00275 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HEC60_00285 ENOG4108P2H Inner membrane protein YjiG HEC60_00290 ENOG41074DU domain protein HEC60_00295 ENOG4105D22 carbon starvation protein HEC60_00300 ENOG4105VCD cytoplasmic protein HEC60_00315 ENOG4105GTN ParB Domain Protein Nuclease HEC60_00320 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HEC60_00325 ENOG4105DQS Transcriptional regulator HEC60_00330 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HEC60_00335 ENOG4105D3R alkyl hydroperoxide reductase HEC60_00340 ENOG4108JU3 Alkyl hydroperoxide reductase HEC60_00345 ENOG4108U51 Universal stress protein HEC60_00350 ENOG4105NXH GreA GreB family elongation factor HEC60_00360 ENOG4105KTS ribonuclease HEC60_00365 ENOG4105CEE C4-dicarboxylate transporter HEC60_00370 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HEC60_00380 ENOG4107Z6W Protein CrcB homolog HEC60_00390 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEC60_00395 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HEC60_00400 ENOG41064T2 transcriptional regulator, lysR family HEC60_00405 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEC60_00410 ENOG4108Z43 UPF0250 protein HEC60_00415 ENOG4105DZ1 carboxypeptidase HEC60_00420 ENOG4105K6T rare lipoprotein A HEC60_00425 ENOG4105CNI cell division protein FtsW HEC60_00430 ENOG4105CJN penicillin-binding protein HEC60_00435 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HEC60_00440 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HEC60_00445 ENOG4108TGR phosphatase HEC60_00450 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HEC60_00455 ENOG4105DJF DNA polymerase III, delta' subunit HEC60_00470 ENOG4107PAI alpha helical protein HEC60_00475 ENOG4105CDA abc transporter atp-binding protein HEC60_00480 ENOG4105DRP amino acid AbC transporter HEC60_00485 ENOG4105EAD ABC transporter HEC60_00490 ENOG4107RP9 extracellular solute-binding protein, family 3 HEC60_00495 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HEC60_00500 ENOG4108JU5 Magnesium and cobalt efflux protein HEC60_00505 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HEC60_00510 ENOG4105C9A Phoh family HEC60_00520 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HEC60_00560 ENOG4105CAQ asparagine synthetase HEC60_00565 ENOG4105D4U had-superfamily hydrolase, subfamily iia HEC60_00570 ENOG4105E2R ROK family HEC60_00575 ENOG4105CE4 GlcNAc 6-P deacetylase HEC60_00585 ENOG4105CI1 PTS System HEC60_00590 ENOG4105CX6 glutaminyL-tRNA synthetase HEC60_00600 ENOG4105GX6 (LipO)protein HEC60_00605 ENOG41090R7 Ferric uptake HEC60_00610 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HEC60_00615 ENOG4105NNH LexA regulated protein HEC60_00620 ENOG4105EV9 Alpha Beta Hydrolase HEC60_00625 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HEC60_00630 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HEC60_00640 ENOG4105D5Q Arginine ornithine antiporter HEC60_00645 ENOG4105CXN decarboxylase HEC60_00655 ENOG4105EEX Two component transcriptional regulator (Winged helix family HEC60_00660 ENOG4105C08 Histidine kinase HEC60_00665 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HEC60_00670 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEC60_00675 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HEC60_00685 ENOG4105XIQ Protein of unknown function (DUF2517) HEC60_00690 ENOG4105CVP deoxyribo-dipyrimidine photolyase HEC60_00695 ENOG4105DUX Transporter HEC60_00700 ENOG4107QNR UPF0135 protein HEC60_00705 ENOG4105P4J Allophanate hydrolase, subunit 1 HEC60_00710 ENOG4107R7A Allophanate hydrolase subunit 2 HEC60_00725 ENOG4105BZN citrate synthase HEC60_00730 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HEC60_00735 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HEC60_00740 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEC60_00745 ENOG4105E33 succinate dehydrogenase HEC60_00750 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HEC60_00755 ENOG4105C7S Dehydrogenase HEC60_00760 ENOG4105CMV Succinyl-CoA synthetase subunit beta HEC60_00765 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HEC60_00770 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC60_00775 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC60_00785 ENOG4105KJB cyd operon protein YbgE HEC60_00790 ENOG4107YD3 Thioesterase HEC60_00795 ENOG4105E02 MotA TolQ exbB proton channel HEC60_00815 ENOG4105KCK Peptidoglycan-associated lipoprotein HEC60_00820 ENOG4105UFD tol-pal system protein YbgF HEC60_00860 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HEC60_00865 ENOG4105PGM cation diffusion facilitator family transporter HEC60_00870 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC60_00875 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEC60_00880 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HEC60_00885 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HEC60_00890 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HEC60_00895 ENOG4105CMR udp-glucose 4-epimerase HEC60_00900 ENOG4105DKW ABC transporter HEC60_00905 ENOG4105F4R Transcriptional regulator mode HEC60_00915 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HEC60_00920 ENOG4105E0C molybdate abc transporter HEC60_00930 ENOG4108K4B hydrolase HEC60_00935 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HEC60_00940 ENOG4105NBR Pectinesterase HEC60_00950 ENOG41088SP formiminoglutamate hydrolase HEC60_00965 ENOG4105C84 Histidine ammonia-lyase HEC60_00970 ENOG4105C85 amino acid HEC60_00975 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HEC60_00980 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HEC60_00990 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HEC60_01005 ENOG4105ECM Sensor protein basS pmrB HEC60_01010 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC60_01015 ENOG4105DIJ Phosphoethanolamine transferase HEC60_01020 ENOG4105CHW UPF0052 protein HEC60_01025 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HEC60_01030 ENOG4108RIR Molybdenum cofactor biosynthesis protein HEC60_01040 ENOG4105M00 molybdopterin converting factor, subunit 1 HEC60_01045 ENOG4108ZAF Molybdopterin HEC60_01050 ENOG4105HFZ Membrane HEC60_01055 ENOG4105DZQ phospholipase D Transphosphatidylase HEC60_01060 ENOG4105I9U inner membrane protein ybhQ HEC60_01065 ENOG4107QWP ABC-2 type transporter HEC60_01070 ENOG4107QWP ABC-2 type transporter HEC60_01075 ENOG4105CJ1 ABC, transporter HEC60_01080 ENOG4105D0S secretion protein (HlyD HEC60_01085 ENOG4107MVR Transcriptional regulator HEC60_01090 ENOG4105C1J atp-dependent rna helicase HEC60_01095 ENOG4105DVT helicase HEC60_01100 ENOG4108MTB glycosyl transferase family HEC60_01110 ENOG4105C7N Xanthine uracil vitamin C permease HEC60_01115 ENOG4105VR4 UPF0379 protein ybiJ HEC60_01120 ENOG4105KSC Transcriptional regulator, TraR DksA family HEC60_01125 ENOG4105ZY9 UPF0379 protein ybiM HEC60_01135 ENOG4105D8X mechanosensitive ion channel HEC60_01140 ENOG4105CDA abc transporter atp-binding protein HEC60_01145 ENOG4105E5Q amino acid AbC transporter HEC60_01150 ENOG4107R0W ABC transporter HEC60_01155 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HEC60_01165 ENOG4108T1M outer membrane protein x HEC60_01170 ENOG4108I6E Sulfatase HEC60_01180 ENOG4105KST dependent repressor HEC60_01185 ENOG4105F4P )-transporter HEC60_01190 ENOG4105CPC Aldo Keto reductase HEC60_01195 ENOG4105CS2 ec 3.2.1.21 HEC60_01205 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC60_01210 ENOG4105C5H ABC transporter HEC60_01220 ENOG4105DPW Major facilitator superfamily MFS_1 HEC60_01225 ENOG4105ETE Transcriptional regulator (LacI family HEC60_01230 ENOG41072TH Protein of unknown function (DUF1479) HEC60_01235 ENOG4108HCJ Hydrolase HEC60_01245 ENOG4105F1A Pyruvate formate-lyase HEC60_01250 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEC60_01255 ENOG4105D06 uba thif-type nad fad binding protein HEC60_01260 ENOG4105CVM Molybdenum cofactor synthesis domain protein HEC60_01265 ENOG4105D44 asparaginase HEC60_01275 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC60_01280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC60_01290 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HEC60_01295 ENOG4105C2W permease HEC60_01310 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HEC60_01315 ENOG4108TGY Glutathione S-transferase HEC60_01320 ENOG4105DZ1 carboxypeptidase HEC60_01325 ENOG4107FB0 transcriptional regulator DeoR family HEC60_01330 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEC60_01335 ENOG4107QF7 multi-drug HEC60_01340 ENOG4108HCJ Hydrolase HEC60_01345 ENOG4106UW1 Major Facilitator superfamily HEC60_01350 ENOG4108RFG Tetr family transcriptional regulator HEC60_01355 ENOG4105CHR reductase HEC60_01365 ENOG4105GWF inner membrane protein YbjM HEC60_01370 ENOG41090BQ Glutaredoxin HEC60_01375 ENOG4108DBC nitroreductase HEC60_01380 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HEC60_01385 ENOG4108RMJ sensory transduction regulator HEC60_01390 ENOG4107RUE extracellular solute-binding protein family 1 HEC60_01395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC60_01400 ENOG4105F38 ABC transporter, permease HEC60_01405 ENOG4105D38 putrescine abc transporter HEC60_01410 ENOG4105RBQ inner membrane protein ybjO HEC60_01415 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HEC60_01425 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HEC60_01430 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) HEC60_01435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC60_01440 ENOG4105C08 Histidine kinase HEC60_01450 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HEC60_01455 ENOG4106TNF Periplasmic binding protein HEC60_01460 ENOG4105DMR ABC, transporter HEC60_01465 ENOG4105GBT ABC transporter HEC60_01470 ENOG4106PMH Extracellular solute-binding protein family 3 HEC60_01475 ENOG4105E5Z arginine transporter ATP-binding subunit HEC60_01480 ENOG41064MM (LipO)protein HEC60_01490 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HEC60_01510 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HEC60_01515 ENOG4105CGD Nad-dependent epimerase dehydratase HEC60_01520 ENOG4105C5W Aldolase HEC60_01525 ENOG4105C7K acetolactate synthase HEC60_01530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC60_01540 ENOG4105DWU Membrane HEC60_01545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC60_01550 ENOG4105CPB ATP-dependent endonuclease of the OLD family HEC60_01555 ENOG4108MJ5 VirK protein HEC60_01560 ENOG4105DJY efflux transporter, rnd family, mfp subunit HEC60_01570 ENOG4105VEQ Cold shock protein HEC60_01580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC60_01590 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HEC60_01595 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HEC60_01600 ENOG4108JJ8 (ABC) transporter HEC60_01605 ENOG4108JJ9 ABC, transporter HEC60_01610 ENOG4105C3M thioredoxin reductase HEC60_01615 ENOG4105EW9 transcriptional regulator AsnC family HEC60_01620 ENOG4105CNU cell division protein FtsK HEC60_01630 ENOG4105D1H recombination factor protein RarA HEC60_01635 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HEC60_01640 ENOG4107QY8 reductase HEC60_01645 ENOG4105QAX Iron-sulfur HEC60_01650 ENOG4107KGK dmso reductase anchor subunit HEC60_01655 ENOG4108ISG Major Facilitator HEC60_01660 ENOG4105E5D amino acid HEC60_01665 ENOG4105F1A Pyruvate formate-lyase HEC60_01670 ENOG4105C6N Formate acetyltransferase HEC60_01675 ENOG4105TMB Formate nitrite transporter HEC60_01680 ENOG4105DDY UPF0142 protein ycaO HEC60_01685 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HEC60_01700 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HEC60_01705 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HEC60_01715 ENOG4105BZ1 (ABC) transporter HEC60_01720 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HEC60_01725 ENOG4105T0Z Conserved Protein HEC60_01730 ENOG4105W49 UPF0434 protein HEC60_01735 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HEC60_01760 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEC60_01765 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HEC60_01770 ENOG4107S90 membrAne HEC60_01775 ENOG4106371 Methyltransferase HEC60_01780 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HEC60_01785 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HEC60_01795 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HEC60_01800 ENOG4105EAQ (twin-arginine translocation) pathway signal HEC60_01805 ENOG4105C5X domain protein HEC60_01810 ENOG4105CGF Aromatic amino acid aminotransferase HEC60_01815 ENOG4105ZIT Porin Gram-negative type HEC60_01820 ENOG4105C5S asparaginyl-tRNA synthetase HEC60_01825 ENOG4107RH7 Nicotinate phosphoribosyltransferase HEC60_01830 ENOG4105CD8 aminopeptidase N HEC60_01835 ENOG4105E2Y ABC, transporter HEC60_01840 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HEC60_01845 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HEC60_01850 ENOG4105GVF (ABC) transporter HEC60_01855 ENOG4108UZX fmn reductase HEC60_01865 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HEC60_01870 ENOG4105QVC MOSC domain-containing protein HEC60_01875 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HEC60_01880 ENOG4105C5H ABC transporter HEC60_01885 ENOG4105F1S paraquat-inducible protein a HEC60_01890 ENOG4105DY2 Paraquat-inducible protein b HEC60_01895 ENOG4108Q2G (LipO)protein HEC60_01900 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HEC60_01910 ENOG4105DAN ATP-dependent protease HEC60_01915 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HEC60_01920 ENOG4105UYK outer membrane protein a HEC60_01930 ENOG4108RZ1 DNA transformation protein HEC60_01935 ENOG4105EM2 membrane HEC60_01940 ENOG410901E Membrane HEC60_01945 ENOG41088T4 Helicase IV HEC60_01950 ENOG4108Z5K methylglyoxal synthase HEC60_01955 ENOG4108Q67 UPF0319 protein HEC60_01960 ENOG4105K4P CoA-binding domain protein HEC60_01965 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HEC60_01975 ENOG4108V1U phospholipid-binding protein HEC60_01985 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HEC60_02020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HEC60_02030 ENOG4108MN8 Membrane HEC60_02035 ENOG4107QSI ABC, transporter HEC60_02070 ENOG41070YT Rac prophage HEC60_02120 ENOG41076J9 exonuclease VIII HEC60_02130 ENOG4107C82 Rac prophage HEC60_02380 ENOG4105XXV Acid-resistance protein HEC60_02385 ENOG4105D5Q Arginine ornithine antiporter HEC60_02390 ENOG4106ZGR Transcriptional regulator HEC60_02395 ENOG41060V2 Acid-resistance protein HEC60_02400 ENOG4108YK4 Acid-resistance membrane protein HEC60_02405 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HEC60_02410 ENOG4105CXN decarboxylase HEC60_02415 ENOG4105BZU Histidine kinase HEC60_02420 ENOG4105BZU Histidine kinase HEC60_02425 ENOG4105FV3 HEC60_02430 ENOG4108TC1 Transcriptional regulator HEC60_02435 ENOG4105D6F Phosphatase HEC60_02440 ENOG4105XH3 HEC60_02445 ENOG4105CS1 NAD(P)H quinone oxidoreductase HEC60_02450 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HEC60_02460 ENOG4108R86 Transcriptional regulator HEC60_02470 ENOG4105C26 Dehydrogenase HEC60_02475 ENOG4105CK7 Sodium proline symporter HEC60_02490 ENOG4105DBE peroxidase HEC60_02495 ENOG4105D5M phosphate starvation-inducible protein HEC60_02505 ENOG4105CHJ isochorismatase hydrolase HEC60_02510 ENOG4105EUB pirin domain protein HEC60_02515 ENOG4105CC0 LysR family Transcriptional regulator HEC60_02525 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HEC60_02530 ENOG4107SSZ Phosphatase HEC60_02535 ENOG4107XHZ cytoplasmic chaperone TorD family protein HEC60_02540 ENOG4108UQ5 membrane protein YcdZ HEC60_02545 ENOG4105P8Q Curli production assembly transport component CsgG HEC60_02550 ENOG4108WYR Curli production assembly transport component, CsgF HEC60_02555 ENOG4108XDW curli assembly protein CsgE HEC60_02560 ENOG41086KC Transcriptional regulator HEC60_02565 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HEC60_02570 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HEC60_02575 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HEC60_02580 ENOG41068SS HEC60_02585 ENOG4108UVJ appr-1-p processing domain protein HEC60_02600 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HEC60_02605 ENOG4105NAC (LipO)protein HEC60_02610 ENOG4108W47 Acidic protein msyB HEC60_02620 ENOG4105D1S lipid A biosynthesis HEC60_02630 ENOG4106974 biofilm formation HEC60_02635 ENOG4105F76 Sarcosine oxidase HEC60_02640 ENOG4105PVA Biofilm formation regulatory protein BssS HEC60_02645 ENOG4105MEA DNA damage-inducible protein i HEC60_02650 ENOG4105EKE dihydroorotase HEC60_02655 ENOG4105F3T (LipO)protein HEC60_02665 ENOG4105D9U N-acetyltransferase HEC60_02670 ENOG4108YXG UPF0502 protein HEC60_02675 ENOG4105EP9 oxidoreductase HEC60_02680 ENOG4105CJR Integral membrane protein (MviN HEC60_02685 ENOG4105QVD Flagella synthesis protein FlgN HEC60_02690 ENOG4105M9M anti-sigma28 factor FlgM HEC60_02695 ENOG4105CKS Flagella basal body P-ring formation protein flgA HEC60_02700 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HEC60_02705 ENOG4108ZC9 flagellar basal-body rod protein flgc HEC60_02710 ENOG4105W00 Flagellar hook capping protein HEC60_02715 ENOG4105BZE flagellar hook protein, FlgE HEC60_02720 ENOG4108KPB Flagellar basal-body rod protein FlgF HEC60_02725 ENOG4105CGA flagellar basal-body rod protein FlgG HEC60_02740 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HEC60_02745 ENOG4105E1Q flagellar hook-associated protein HEC60_02750 ENOG4105DTJ flagellar hook-associated protein HEC60_02755 ENOG4107QQB Ribonuclease E HEC60_02760 ENOG4105EI2 Pseudouridine synthase HEC60_02765 ENOG4108UHJ MAF-like protein HEC60_02770 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HEC60_02775 ENOG4105VGS 50s ribosomal protein l32 HEC60_02780 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HEC60_02785 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HEC60_02790 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HEC60_02795 ENOG4105CHR reductase HEC60_02800 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEC60_02805 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC60_02810 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HEC60_02815 ENOG4105HHA aminodeoxychorismate lyase HEC60_02825 ENOG4107QRG dna polymerase iii HEC60_02830 ENOG4105F8V Hydrolase, tatD family HEC60_02835 ENOG4105CI1 PTS System HEC60_02840 ENOG4105K59 histidine triad (HIT) protein HEC60_02845 ENOG41090DQ Lipoprotein HEC60_02850 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HEC60_02855 ENOG4108RUM thiamine kinase HEC60_02865 ENOG4105D0Y UPF0227 protein HEC60_02870 ENOG4105CEP NADH dehydrogenase HEC60_02875 ENOG4107MBR 17 kDa surface antigen HEC60_02880 ENOG4108IND Tetr family transcriptional regulator HEC60_02885 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HEC60_02890 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC60_02895 ENOG4108JA2 transcriptioN-repair coupling factor HEC60_02900 ENOG4105IQC Inner membrane protein YcfT HEC60_02905 ENOG4105D60 lipoprotein releasing system transmembrane protein HEC60_02915 ENOG4105D60 lipoprotein releasing system transmembrane protein HEC60_02920 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HEC60_02925 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HEC60_02930 ENOG4108HM4 ABC transporter HEC60_02935 ENOG4105D38 putrescine abc transporter HEC60_02940 ENOG4105DZW Dipeptidase HEC60_02960 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HEC60_02965 ENOG4108UK5 Transposase HEC60_02970 ENOG4105EZE Cupin 4 family protein HEC60_02975 ENOG4105IFJ Histidine kinase HEC60_02985 ENOG4107QTF adenylosuccinate lyase HEC60_02995 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HEC60_03010 ENOG4108HMX isocitrate dehydrogenase (NADP) HEC60_03030 ENOG4105EQR Transposase IS116 IS110 IS902 HEC60_03075 ENOG4108K81 inner membrane protein YghB HEC60_03080 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HEC60_03120 ENOG4105KME endoribonuclease L-psp HEC60_03135 ENOG4105CW0 outer membrane usher protein HEC60_03140 ENOG4108FZ9 Chaperone HEC60_03150 ENOG4105BZU Histidine kinase HEC60_03180 ENOG4105EQR Transposase IS116 IS110 IS902 HEC60_03275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC60_03305 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HEC60_03310 ENOG4105F9F transposase HEC60_03330 ENOG4105NAE bifunctional deaminase-reductase domain protein HEC60_03355 ENOG4105KBH arsR family transcriptional regulator HEC60_03360 ENOG4105CAU Arsenical resistance protein, ArsH HEC60_03370 ENOG4106IAW HEC60_03380 ENOG4105W3V DNA-binding, transcriptional regulator HEC60_03385 ENOG4105E2V Glycosyltransferase 36 HEC60_03390 ENOG4105VEQ Cold shock protein HEC60_03410 ENOG4108I1J Integrase HEC60_03415 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 HEC60_03435 ENOG4108S1U HEC60_03450 ENOG4108UZ3 Transporter HEC60_03465 ENOG4105EXG Transcriptional regulator HEC60_03470 ENOG4105VSH 4-oxalocrotonate tautomerase HEC60_03475 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HEC60_03565 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HEC60_03580 ENOG4108S1B Periplasmic chaperone protein HEC60_03585 ENOG4105E6S usher protein( HEC60_03600 ENOG4105D5Q Arginine ornithine antiporter HEC60_03605 ENOG4105DND Transcriptional regulator HEC60_03610 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC60_03615 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC60_03620 ENOG4105J92 DNA-binding transcriptional activator GutM HEC60_03625 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HEC60_03630 ENOG4105VI0 Pts system, glucitol sorbitol-specific HEC60_03635 ENOG4105DZY Pts system, glucitol sorbitol-specific HEC60_03640 ENOG410787A Pts system, glucitol sorbitol-specific HEC60_03645 ENOG4107TYG Oxidoreductase domain-containing protein HEC60_03695 ENOG4105V2F Uncharacterized protein yoac HEC60_03720 ENOG41074AV Hok/gef family HEC60_03735 ENOG4105BZU Histidine kinase HEC60_03765 ENOG4108QBX (LipO)protein HEC60_03775 ENOG4105QVC MOSC domain-containing protein HEC60_03775 ENOG4105QVC MOSC domain-containing protein HEC60_03790 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HEC60_03825 ENOG4108P6C Tryptophan transporter of low affinity HEC60_03835 ENOG4108KHP Diguanylate cyclase HEC60_03840 ENOG4108HMX isocitrate dehydrogenase (NADP) HEC60_03885 ENOG4105CUC YeeE YedE family protein HEC60_03900 ENOG4105C31 Tryptophanyl-tRNA synthetase HEC60_03905 ENOG4105S5I Membrane HEC60_03910 ENOG4105BZU Histidine kinase HEC60_03915 ENOG4106G4W HEC60_03920 ENOG410620I Diguanylate cyclase HEC60_03945 ENOG4108MBX Secretion Protein HEC60_03950 ENOG4108JJA ABC, transporter HEC60_03955 ENOG4105UCG Domain of unknown function (DUF333) HEC60_03965 ENOG4105K78 MarR family Transcriptional regulator HEC60_03970 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEC60_03975 ENOG4105DJ2 Major Facilitator Superfamily HEC60_03980 ENOG4105R1U AraC Family Transcriptional Regulator HEC60_03985 ENOG4108VMM UPF0756 membrane protein HEC60_03990 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HEC60_04000 ENOG4105CYN Serine protein kinase HEC60_04005 ENOG4105GNX MltA-interacting MipA family protein HEC60_04010 ENOG4105DSB aldose 1-epimerase HEC60_04015 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEC60_04020 ENOG4105E0X reductase HEC60_04025 ENOG4105VUT cytoplasmic protein HEC60_04035 ENOG4105CPQ Dehydrogenase HEC60_04040 ENOG4107TE1 transport protein HEC60_04045 ENOG4105CPQ Dehydrogenase HEC60_04050 ENOG4105D2N Aldolase HEC60_04055 ENOG4107UH8 sugar kinase HEC60_04060 ENOG4105CPC Aldo Keto reductase HEC60_04065 ENOG4105E98 transcriptional regulator DeoR family HEC60_04070 ENOG4108KUU Inner membrane metabolite transport protein ydjE HEC60_04075 ENOG4108RWI nicotinamidase HEC60_04080 ENOG4105HDK L-asparaginase HEC60_04085 ENOG4105D07 Signal peptide peptidase, SppA HEC60_04090 ENOG41069NU Nitroreductase HEC60_04095 ENOG4105SBG acid phosphatase HEC60_04100 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HEC60_04105 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC60_04110 ENOG4105D82 Glutamate dehydrogenase HEC60_04115 ENOG4105MTM Protein of unknown function (DUF1496) HEC60_04120 ENOG4105M6F mutator MutT protein HEC60_04125 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEC60_04130 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HEC60_04135 ENOG4107RM6 sulfurtransferase HEC60_04140 ENOG4108VGW abc transporter atp-binding protein HEC60_04145 ENOG4105CXZ ABC transporter, permease HEC60_04150 ENOG4105VNH ABC transporter solute-binding protein HEC60_04160 ENOG4105CGK Exodeoxyribonuclease III HEC60_04165 ENOG4105C8Y Acetylornithine aminotransferase HEC60_04170 ENOG4105F4X arginine HEC60_04175 ENOG4105C26 Dehydrogenase HEC60_04180 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HEC60_04190 ENOG4108SPG Periplasmic Protein HEC60_04195 ENOG41090B9 response to stress HEC60_04205 ENOG4105KKI DNA-binding transcriptional activator OsmE HEC60_04210 ENOG4105VZJ PTS System HEC60_04215 ENOG4105CK1 PTS System HEC60_04220 ENOG4105VCP PTS System HEC60_04225 ENOG4105EZV Transcriptional regulator HEC60_04230 ENOG4105F8D glycoside hydrolase family 4 HEC60_04240 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HEC60_04245 ENOG4108ETY sodium dicarboxylate symporter HEC60_04250 ENOG4107K5X Membrane-bound metal-dependent hydrolase HEC60_04255 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HEC60_04260 ENOG4107PN8 YfeABCD locus regulator HEC60_04265 ENOG4105NAU thioesterase Superfamily protein HEC60_04270 ENOG4107835 probably involved in intracellular septation (By similarity) HEC60_04280 ENOG4105EIF outer membrane protein W HEC60_04290 ENOG4105KT5 UmuD protein HEC60_04295 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEC60_04315 ENOG4105N0E Protein of unknown function (DUF2543) HEC60_04325 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HEC60_04360 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HEC60_04365 ENOG4105DUU IucA IucC family protein HEC60_04390 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HEC60_04405 ENOG4105ED1 spovr family HEC60_04410 ENOG4105MWK D-amino acid dehydrogenase, small subunit HEC60_04420 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HEC60_04425 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HEC60_04435 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HEC60_04445 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC60_04450 ENOG4105J4Q Transcriptional regulator HEC60_04455 ENOG4105TIK HEC60_04460 ENOG4107BVS HEC60_04465 ENOG4105Q3Y exported protein HEC60_04480 ENOG4105EQ0 Major Facilitator superfamily HEC60_04485 ENOG4105CR8 Transcriptional regulator HEC60_04490 ENOG4105CJN penicillin-binding protein HEC60_04495 ENOG4105DHI Methyltransferase HEC60_04505 ENOG4108NK4 UPF0266 membrane protein HEC60_04510 ENOG4105F3R pts system mannose fructose sorbose family iid HEC60_04515 ENOG4105ETZ PTS System HEC60_04520 ENOG4105DAS pts system HEC60_04525 ENOG4105EE5 Membrane protein terC HEC60_04530 ENOG4107XTP (EAL) domain protein HEC60_04535 ENOG4105EJQ L-serine dehydratase HEC60_04550 ENOG4105X5C UPF0181 protein HEC60_04555 ENOG4105M4H endoribonuclease L-psp HEC60_04560 ENOG4105DVT helicase HEC60_04565 ENOG41072GX Peptidase M22 Glycoprotease HEC60_04570 ENOG4105Y4Z Outer Membrane Lipoprotein HEC60_04575 ENOG4105CEY Amp-dependent synthetase and ligase HEC60_04580 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HEC60_04590 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HEC60_04595 ENOG4107QMS site-determining protein HEC60_04605 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HEC60_04615 ENOG4105DK0 Indole-3-glycerol phosphate synthase HEC60_04620 ENOG4108EFP Anthranilate synthase component II HEC60_04625 ENOG4105CRQ synthase (Component I) HEC60_04630 ENOG4105DB7 PHP domain protein HEC60_04635 ENOG4107RTD sua5 ycio yrdc ywlc family protein HEC60_04645 ENOG4105FE9 pseudouridine synthase HEC60_04650 ENOG4105CT4 transporter HEC60_04660 ENOG41075H3 AraC family transcriptional regulator HEC60_04665 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEC60_04670 ENOG4105UBK short-chain dehydrogenase reductase HEC60_04675 ENOG4105ERU peptidase HEC60_04680 ENOG4105RKX Protein of unknown function (DUF2498) HEC60_04685 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HEC60_04690 ENOG4107R11 Transcriptional regulator HEC60_04700 ENOG4107QM5 aconitate hydratase HEC60_04705 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HEC60_04710 ENOG4105EYK Phosphatidylglycerophosphatase B HEC60_04715 ENOG4105Q4A inner membrane protein yciS HEC60_04720 ENOG4105CFV Tetratricopeptide repeat protein HEC60_04730 ENOG4108ZJT translation initiation factor, Sui1 HEC60_04740 ENOG4105N2W Transcriptional regulator HEC60_04750 ENOG4105E39 Enoyl-CoA hydratase HEC60_04755 ENOG4105BZU Histidine kinase HEC60_04760 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HEC60_04765 ENOG4105Q4T oxidoreductase HEC60_04770 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HEC60_04780 ENOG4108JQ2 peptide transport system atp-binding protein HEC60_04785 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HEC60_04790 ENOG4108EU3 peptide transport system, permease HEC60_04795 ENOG4108EKA peptide transport system, permease HEC60_04800 ENOG4108J59 Extracellular solute-binding protein, family 5 HEC60_04805 ENOG4105E51 psp operon transcriptional activator HEC60_04810 ENOG41087YS Phage shock protein A HEC60_04815 ENOG4105YYT phage shock protein B HEC60_04820 ENOG4105FM1 phage shock protein C HEC60_04825 ENOG4105NNG Peripheral inner membrane phage-shock protein HEC60_04830 ENOG4105CM6 amino acid regulated cytosolic protein HEC60_04835 ENOG4106K28 UPF0283 membrane protein HEC60_04840 ENOG4108XNW Transcriptional activatory protein CaiF HEC60_04850 ENOG4106YT9 Enoyl-CoA hydratase HEC60_04855 ENOG4105CEY Amp-dependent synthetase and ligase HEC60_04865 ENOG4105C1G acyl-Coa dehydrogenase HEC60_04870 ENOG4105C94 Transporter HEC60_04885 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEC60_04890 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HEC60_04895 ENOG4105C54 Major Facilitator superfamily HEC60_04900 ENOG4105E3S small subunit HEC60_04905 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC60_04910 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HEC60_04915 ENOG4105DPX Hydrogenase, large subunit HEC60_04920 ENOG4108USZ hydrogenase HEC60_04925 ENOG4108WGS hydrogenase 2-specific chaperone HEC60_04930 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HEC60_04935 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HEC60_04945 ENOG4108JU8 Transcriptional regulator HEC60_04950 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HEC60_04955 ENOG4107S8C mandelate racemase muconate lactonizing HEC60_04960 ENOG4105KXI murein peptide amidase A HEC60_04965 ENOG4107QSI ABC, transporter HEC60_04970 ENOG4105BZU Histidine kinase HEC60_04975 ENOG4105BZU Histidine kinase HEC60_04980 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_04985 ENOG4107RX3 Mg2 transporter protein cora family protein HEC60_05000 ENOG4108RHM integral membrane protein HEC60_05005 ENOG4105FCK Membrane HEC60_05010 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HEC60_05015 ENOG4105S66 prophage protein HEC60_05025 ENOG4108PNB DNA-binding transcriptional regulator HEC60_05030 ENOG4108ZXC Two component transcriptional regulator, luxr family HEC60_05035 ENOG4106AFQ Histidine kinase HEC60_05040 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC60_05045 ENOG4106WHD Tetrathionate reductase HEC60_05050 ENOG4105DB1 molybdopterin oxidoreductase HEC60_05055 ENOG4105IKK cytoplasmic protein HEC60_05060 ENOG41090X5 Heat shock protein hslJ HEC60_05065 ENOG4105C5I Dehydrogenase HEC60_05070 ENOG4108NIW Leucine export protein LeuE HEC60_05075 ENOG4107H52 Dicarboxylate transport HEC60_05080 ENOG410689M (LipO)protein HEC60_05085 ENOG4105WXT Conserved Protein HEC60_05090 ENOG4108WFR AraC Family Transcriptional Regulator HEC60_05095 ENOG4105C26 Dehydrogenase HEC60_05100 ENOG4105EUR Domain-Containing protein HEC60_05105 ENOG4105UYK outer membrane protein a HEC60_05120 ENOG41061H0 Monooxygenase HEC60_05130 ENOG4105F11 amine oxidase HEC60_05135 ENOG4105DXM phenylacetic acid degradation protein HEC60_05140 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HEC60_05145 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HEC60_05150 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HEC60_05155 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HEC60_05160 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC60_05165 ENOG4105E39 Enoyl-CoA hydratase HEC60_05170 ENOG4108UKI Enoyl-CoA hydratase HEC60_05175 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEC60_05180 ENOG4108ZJI phenylacetic acid degradation protein HEC60_05185 ENOG4105CHU acetyl-coa acetyltransferase HEC60_05190 ENOG4105DZS Phenylacetate-CoA ligase HEC60_05195 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HEC60_05200 ENOG4108Z0R Transferase HEC60_05205 ENOG4107635 Hok Gef family protein HEC60_05210 ENOG4108W2Y isochorismatase HEC60_05220 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HEC60_05225 ENOG4105CQ7 ATP-dependent helicase HEC60_05230 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HEC60_05250 ENOG4107DB1 DUF218 domain HEC60_05255 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HEC60_05260 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HEC60_05265 ENOG4105CPW cytochrome b561 HEC60_05270 ENOG4108YS1 cytoplasmic protein HEC60_05275 ENOG4105YP6 Domain of unknown function (DUF1869) HEC60_05285 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HEC60_05305 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_05310 ENOG4105DDW LysR family Transcriptional regulator HEC60_05315 ENOG4105E32 cytoplasmic protein HEC60_05320 ENOG4105EBR Carboxylesterase HEC60_05325 ENOG4105DUM transcriptional regulator, lysR family HEC60_05330 ENOG4105CHM Aminotransferase HEC60_05335 ENOG4105E89 ABC transporter HEC60_05345 ENOG4108Z9I -acetyltransferase HEC60_05350 ENOG4107WE3 acetyltransferase YdcK HEC60_05355 ENOG41088CC tellurite resistance protein tehB HEC60_05360 ENOG4108KKZ (LipO)protein HEC60_05365 ENOG4105DWP Membrane HEC60_05375 ENOG4105DKK Benzoate HEC60_05380 ENOG4108JCI Transcriptional regulator HEC60_05385 ENOG4105CFP Peptidase U32 HEC60_05400 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HEC60_05405 ENOG4105C4M (Ubiquinol oxidase) subunit I HEC60_05420 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEC60_05425 ENOG4107TYH extracellular solute-binding protein family 1 HEC60_05430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HEC60_05435 ENOG4105D81 ABC transporter, permease HEC60_05440 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HEC60_05445 ENOG4105C26 Dehydrogenase HEC60_05455 ENOG410654E Membrane HEC60_05480 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC60_05485 ENOG4105R71 cytoplasmic protein HEC60_05490 ENOG4108T9Y Inner membrane protein ydcZ HEC60_05495 ENOG4108Z7F N-acetyltransferase HEC60_05505 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HEC60_05510 ENOG4108WYP Transcriptional regulator HEC60_05515 ENOG4105CHB tonB-dependent Receptor HEC60_05520 ENOG4108NS2 receptor HEC60_05525 ENOG4105SUV lipoprotein YgdR HEC60_05530 ENOG4107EF2 surface-exposed virulence protein HEC60_05535 ENOG4105C85 amino acid HEC60_05540 ENOG4108N27 Glutathione S-transferase HEC60_05555 ENOG4108MEJ flavin reductase domain protein HEC60_05560 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HEC60_05565 ENOG4105D0D Nitrate reductase 2, gamma subunit HEC60_05570 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HEC60_05575 ENOG4108IUE nitrate reductase beta subunit HEC60_05580 ENOG4105CRU nitrate reductase, alpha subunit HEC60_05585 ENOG4107QND Nitrite extrusion protein HEC60_05610 ENOG4108MBX Secretion Protein HEC60_05620 ENOG4105RPH Inner membrane protein YddG HEC60_05630 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC60_05635 ENOG4108MG3 formate dehydrogenase HEC60_05650 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HEC60_05655 ENOG4105C5H ABC transporter HEC60_05665 ENOG4107R1I NAD-dependent malic enzyme HEC60_05680 ENOG4105EXG Transcriptional regulator HEC60_05685 ENOG4105CJW magnesium transporter HEC60_05690 ENOG4105DWT malate dehydrogenase (quinone) HEC60_05695 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC60_05705 ENOG4105HMV Fimbrial protein HEC60_05710 ENOG4106PG1 outer membrane usher protein HEC60_05715 ENOG4106P2F Pfam:Pili_assembly_C HEC60_05730 ENOG4106P2F Pfam:Pili_assembly_C HEC60_05745 ENOG4105DSF transport protein HEC60_05750 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HEC60_05755 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HEC60_05760 ENOG4105BZU Histidine kinase HEC60_05765 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HEC60_05785 ENOG4105DFH Transport of potassium into the cell (By similarity) HEC60_05790 ENOG4105D94 Major Facilitator Superfamily HEC60_05795 ENOG4106NZI LysR family Transcriptional regulator HEC60_05800 ENOG4105DAG ROK family HEC60_05805 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HEC60_05810 ENOG4105CMQ Chloride channel HEC60_05815 ENOG4108NEM leader-binding protein dmsD HEC60_05820 ENOG4107QY8 reductase HEC60_05825 ENOG4105KBG Protein of unknown function (DUF1161) HEC60_05835 ENOG4108MK9 spermidine N(1)-acetyltransferase HEC60_05840 ENOG4105M5Q UPF0482 protein HEC60_05845 ENOG4105KK4 UPF0060 membrane protein HEC60_05850 ENOG4105CXK mandelate racemase muconate lactonizing HEC60_05855 ENOG4105CPQ Dehydrogenase HEC60_05865 ENOG4105DEI Mannitol dehydrogenase HEC60_05870 ENOG4107SEY Conserved Protein HEC60_05875 ENOG4107XBN GntR Family Transcriptional Regulator HEC60_05880 ENOG4105EMU Dehydrogenase HEC60_05885 ENOG4105DGW oligopeptidase A HEC60_05895 ENOG4105F4G Membrane HEC60_05915 ENOG4105E5W Transporter HEC60_05920 ENOG4108594 Permease of the drug metabolite transporter HEC60_05925 ENOG4106DNR multiple antibiotic resistance protein HEC60_05930 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HEC60_05935 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEC60_05940 ENOG41082NP Multiple antibiotic resistance HEC60_05945 ENOG4105F27 Major Facilitator HEC60_05950 ENOG4105JAB phenazine biosynthesis protein, phzf family HEC60_05955 ENOG4105EGI Transcriptional regulator HEC60_05960 ENOG4105C26 Dehydrogenase HEC60_05975 ENOG4105M0C cytoplasmic protein HEC60_05980 ENOG4105BZU Histidine kinase HEC60_05995 ENOG4105CZQ inner membrane transport protein YdhC HEC60_06000 ENOG4105EPF Outer membrane porin HEC60_06005 ENOG4108SU4 UPF0309 protein HEC60_06015 ENOG4108SU4 UPF0309 protein HEC60_06020 ENOG4108IQ3 PTS system HEC60_06025 ENOG4105F3R pts system mannose fructose sorbose family iid HEC60_06030 ENOG4105ETZ PTS System HEC60_06040 ENOG4105FDP GntR family transcriptional regulator HEC60_06045 ENOG4105FFC UPF0187 protein HEC60_06075 ENOG4105CSH Transporter HEC60_06085 ENOG4108YYQ gCN5-related N-acetyltransferase HEC60_06095 ENOG4105ETE Transcriptional regulator (LacI family HEC60_06105 ENOG4105CT4 transporter HEC60_06125 ENOG4105C4X radical SAM domain protein HEC60_06130 ENOG4105CBG Sulfatase HEC60_06155 ENOG4105VJY transcriptional regulator HEC60_06170 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEC60_06190 ENOG4105FDK ABC transporter HEC60_06195 ENOG4105EHG Permease protein HEC60_06210 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC60_06215 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HEC60_06230 ENOG4105CT4 transporter HEC60_06235 ENOG4105F8D glycoside hydrolase family 4 HEC60_06240 ENOG4108K2B transcriptional regulator HEC60_06250 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HEC60_06255 ENOG4105F32 YngK protein HEC60_06265 ENOG4108DG9 Smr protein MutS2 HEC60_06270 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEC60_06275 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HEC60_06285 ENOG4105Q9Y Universal stress protein HEC60_06290 ENOG410671Z uncharacterized protein ydiH HEC60_06295 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEC60_06300 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HEC60_06305 ENOG4105C5D exported protein HEC60_06310 ENOG4105D5Q Arginine ornithine antiporter HEC60_06315 ENOG410642E Short chain dehydrogenase HEC60_06320 ENOG4105RA2 Membrane HEC60_06325 ENOG4107EXC regulatoR HEC60_06330 ENOG4105JJR Histidine kinase HEC60_06340 ENOG4105C9Q fumarate hydratase class II HEC60_06350 ENOG4107GFK fumarate HEC60_06355 ENOG4105EIP mannose-6-phosphate isomerase HEC60_06360 ENOG4106J39 exported protein HEC60_06365 ENOG4107P2S Transcriptional regulator HEC60_06370 ENOG4105CI1 PTS System HEC60_06375 ENOG4105C87 Aminotransferase class I and II HEC60_06380 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HEC60_06385 ENOG4105D9R oxidoreductase HEC60_06390 ENOG4106C6R beta-lactam resistance protein HEC60_06400 ENOG4105M9B inner membrane protein ydgK HEC60_06425 ENOG4108UQQ Electron transport complex HEC60_06435 ENOG4105CSM endonuclease III HEC60_06440 ENOG4105DUX Transporter HEC60_06445 ENOG4108K3A Glutathione S-transferase HEC60_06455 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HEC60_06460 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HEC60_06465 ENOG410642K Lysozyme inhibitor HEC60_06475 ENOG4108XTF Outer Membrane Lipoprotein HEC60_06480 ENOG4105BZU Histidine kinase HEC60_06495 ENOG4105Y49 secretion protein, HlyD family HEC60_06500 ENOG4105DSW Fusaric acid resistance protein HEC60_06505 ENOG4107RGM aldo keto reductase HEC60_06515 ENOG4105XZD Fe-S protein HEC60_06520 ENOG4108WUH Transcriptional regulator, TetR family HEC60_06525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC60_06530 ENOG4108UYE Lactoylglutathione lyase HEC60_06535 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HEC60_06540 ENOG4105M2J Glutaredoxin HEC60_06545 ENOG4105K4H Nlp p60 protein HEC60_06550 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HEC60_06555 ENOG4108WUH Transcriptional regulator, TetR family HEC60_06560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC60_06565 ENOG4105F27 Major Facilitator HEC60_06580 ENOG4105F52 Transcriptional regulator HEC60_06585 ENOG4105CZQ inner membrane transport protein YdhC HEC60_06590 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEC60_06595 ENOG4108R6K riboflavin synthase, subunit alpha HEC60_06655 ENOG4105EUZ Beta-lactamase domain protein HEC60_06665 ENOG4105BZU Histidine kinase HEC60_06690 ENOG4105CDA abc transporter atp-binding protein HEC60_06695 ENOG4105E5Q amino acid AbC transporter HEC60_06700 ENOG4106PMH Extracellular solute-binding protein family 3 HEC60_06720 ENOG4105DQ5 transport system permease protein HEC60_06725 ENOG4105E0A ABC, transporter HEC60_06735 ENOG4105S10 periplasmic binding protein HEC60_06740 ENOG4105EHG Permease protein HEC60_06745 ENOG4108W0P ABC transporter HEC60_06750 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HEC60_06755 ENOG4105RFR Protein of unknown function (DUF2767) HEC60_06760 ENOG4105CA9 Pyruvate kinase HEC60_06770 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HEC60_06785 ENOG4105JRK feS assembly protein SufD HEC60_06790 ENOG4105C3K feS assembly ATPase SufC HEC60_06795 ENOG4105DIW FeS assembly protein SUFB HEC60_06800 ENOG4108Z4V iron-sulfur cluster assembly HEC60_06820 ENOG4105Y3U Transglycosylase-associated protein HEC60_06825 ENOG41066VF YeeE YedE family protein HEC60_06835 ENOG4108WF3 methyltransferase HEC60_06840 ENOG4105KA0 thioesterase Superfamily protein HEC60_06845 ENOG4105CQB FAD linked oxidase domain protein HEC60_06850 ENOG4105IPI Membrane HEC60_06860 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HEC60_06870 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC60_06880 ENOG4107ENK receptor HEC60_06885 ENOG4106QJH hemin transport protein HEC60_06890 ENOG4107R4I Periplasmic binding protein HEC60_06895 ENOG4105EHG Permease protein HEC60_06900 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HEC60_06915 ENOG4108QBX (LipO)protein HEC60_06925 ENOG4108V06 Glutathione peroxidase HEC60_06930 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HEC60_06935 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HEC60_06940 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HEC60_06945 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HEC60_06960 ENOG41082NX 50s ribosomal protein l35 HEC60_06965 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HEC60_06980 ENOG4108NE3 Salt-induced outer membrane protein HEC60_06985 ENOG4105DE4 1-phosphofructokinase HEC60_06995 ENOG410822N TonB family HEC60_07005 ENOG4105K9H YciI-like protein HEC60_07015 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HEC60_07020 ENOG4108W5H UPF0263 protein HEC60_07025 ENOG4105EYW Ion transport protein HEC60_07030 ENOG4108JQ7 (ABC) transporter HEC60_07035 ENOG4105C3U ABC transporter HEC60_07040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC60_07045 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC60_07050 ENOG4107QSI ABC, transporter HEC60_07055 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HEC60_07060 ENOG4105C0A alcohol dehydrogenase HEC60_07080 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEC60_07085 ENOG4105I93 response regulator HEC60_07090 ENOG4105D78 K07001 NTE family protein HEC60_07100 ENOG4105CIY formyltetrahydrofolate deformylase HEC60_07115 ENOG41076YT nitrate reductase, gamma subunit HEC60_07120 ENOG4105R3A Nitrate reductase HEC60_07125 ENOG4108IUE nitrate reductase beta subunit HEC60_07130 ENOG4105CRU nitrate reductase, alpha subunit HEC60_07135 ENOG4105DQQ Major facilitator superfamily MFS_1 HEC60_07140 ENOG4105BZU Histidine kinase HEC60_07145 ENOG4105WH1 Two component transcriptional regulator luxr family HEC60_07150 ENOG4105ID0 Putative invasin HEC60_07155 ENOG41090EX DsrE family HEC60_07160 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_07165 ENOG4108NH8 Cation transport protein HEC60_07170 ENOG4105EWV Sodium calcium exchanger membrane region HEC60_07175 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HEC60_07180 ENOG41063JG Transcriptional regulator HEC60_07185 ENOG4108YY7 Invasion gene expression up-regulator SirB HEC60_07190 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HEC60_07195 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HEC60_07205 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HEC60_07210 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HEC60_07215 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HEC60_07225 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HEC60_07230 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HEC60_07235 ENOG4105C3G gtp-binding protein HEC60_07270 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HEC60_07285 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HEC60_07295 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE HEC60_07305 ENOG4108M6W surface presentation of antigens protein SpaS HEC60_07310 ENOG4108TN6 type iii secretion HEC60_07315 ENOG4105U07 type iii secretion HEC60_07320 ENOG41075IY surface presentation of antigens protein SpaP HEC60_07340 ENOG4108JIR Flagellum-specific ATP synthase HEC60_07350 ENOG4108HR8 type iii secretion HEC60_07355 ENOG4108N8R Invasion protein HEC60_07365 ENOG4105YY8 Transcriptional regulator HEC60_07375 ENOG4105Y7Q type iii secretion HEC60_07385 ENOG4108RBT type iii secretion HEC60_07440 ENOG4108FZ9 Chaperone HEC60_07445 ENOG4106PG1 outer membrane usher protein HEC60_07475 ENOG4108IUF type iii secretion HEC60_07480 ENOG4108TN6 type iii secretion HEC60_07485 ENOG41083GP type iii secretion HEC60_07490 ENOG4108HHI Type III secretion system protein HEC60_07495 ENOG41063Q7 Type III secretion system protein HEC60_07510 ENOG4108JIR Flagellum-specific ATP synthase HEC60_07525 ENOG4105UQF type iii secretion HEC60_07580 ENOG4106FZW pathogenicity island effector protein HEC60_07585 ENOG4108SZ7 secretion system effector HEC60_07595 ENOG4105ZQI secreted protein HEC60_07625 ENOG4105BZU Histidine kinase HEC60_07640 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HEC60_07645 ENOG4105EHG Permease protein HEC60_07650 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HEC60_07655 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HEC60_07660 ENOG4105DVA methyltransferase HEC60_07680 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEC60_07685 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HEC60_07695 ENOG4105CUW cytochrome C-TYPE protein HEC60_07700 ENOG4105KWW Biogenesis protein HEC60_07705 ENOG4105KWW Biogenesis protein HEC60_07740 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HEC60_07745 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HEC60_07755 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HEC60_07765 ENOG4105CT4 transporter HEC60_07770 ENOG4105E53 ec 3.2.1.28 HEC60_07780 ENOG4105CN1 protease HEC60_07785 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HEC60_07790 ENOG4108ZGC gaf domain protein HEC60_07795 ENOG4105H2K paraquat-inducible protein a HEC60_07800 ENOG4105DY2 Paraquat-inducible protein b HEC60_07805 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HEC60_07810 ENOG4105WT8 Protein of unknown function (DUF1480) HEC60_07815 ENOG4105UVW uncharacterized protein yebW HEC60_07820 ENOG4108R1E Serine threonine protein phosphatase 1 HEC60_07825 ENOG4108MJ5 VirK protein HEC60_07835 ENOG4105D1S lipid A biosynthesis HEC60_07840 ENOG4105NKT exported protein HEC60_07845 ENOG4108PNC copper resistance HEC60_07850 ENOG4105FXM Copper resistance protein HEC60_07855 ENOG4105MPK DNA polymerase III subunit theta HEC60_07860 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HEC60_07865 ENOG4105UMD exodeoxyribonuclease X HEC60_07870 ENOG4105CUG Oligopeptidase b HEC60_07875 ENOG4108Q2J Inner membrane protein YebE HEC60_07885 ENOG4108UHU Aldolase HEC60_07890 ENOG4105C01 Dihydroxy-acid dehydratase HEC60_07895 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HEC60_07900 ENOG4106KNT transcriptional regulator HEC60_07905 ENOG4105CA9 Pyruvate kinase HEC60_07910 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HEC60_07915 ENOG4105DR5 peptidase HEC60_07920 ENOG4105NXV High-affinity zinc uptake system protein HEC60_07930 ENOG4105FAV ABC, transporter HEC60_07935 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HEC60_07940 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HEC60_07945 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HEC60_07950 ENOG4105CDY transcriptional regulatory protein HEC60_07955 ENOG4108TIT dATP pyrophosphohydrolase HEC60_07960 ENOG4105C9M aspartyl-trna synthetase HEC60_07965 ENOG4105D3W isochorismatase HEC60_07970 ENOG41081XQ Conserved Protein HEC60_07975 ENOG4105WJG Glutathione HEC60_07980 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HEC60_07985 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HEC60_07995 ENOG4106ZCM YecM protein HEC60_08000 ENOG4105C75 arginyL-tRNA synthetase HEC60_08010 ENOG4105F5H Glycosyl Hydrolase Family 88 HEC60_08015 ENOG4105CT4 transporter HEC60_08020 ENOG4105IRD Flagellar protein FlhE HEC60_08025 ENOG4105D7B Flagellar biosynthesis protein flha HEC60_08030 ENOG4105D00 flagellar biosynthetic protein flhB HEC60_08045 ENOG4108VCD Chaperone HEC60_08050 ENOG4105CW0 outer membrane usher protein HEC60_08055 ENOG4108MDY Fimbrial HEC60_08060 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HEC60_08070 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HEC60_08130 ENOG4108K4C ec 3.1.3.12 HEC60_08150 ENOG4108UEC Ferritin-like protein HEC60_08155 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC60_08160 ENOG4105N4N Protein of unknown function (DUF2766) HEC60_08170 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HEC60_08180 ENOG41090A1 ferritin HEC60_08185 ENOG4105VVZ metal-binding protein HEC60_08195 ENOG4106RHG Yeca family HEC60_08200 ENOG4105KAF membrAne HEC60_08340 ENOG4108YV9 Protein of unknown function (DUF2514) HEC60_08380 ENOG4105NI8 Cytosine-specific methyltransferase HEC60_08515 ENOG4105WH1 Two component transcriptional regulator luxr family HEC60_08520 ENOG4105XVG cytoplasmic protein HEC60_08525 ENOG4105VJY transcriptional regulator HEC60_08530 ENOG4105CDA abc transporter atp-binding protein HEC60_08535 ENOG4105E5Q amino acid AbC transporter HEC60_08540 ENOG4105K6H D-cysteine desulfhydrase HEC60_08545 ENOG4105EAB amino acid AbC transporter HEC60_08550 ENOG4108M9K flagella biosynthesis protein FliZ HEC60_08555 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC60_08585 ENOG4105DTS flagellar hook-associated HEC60_08590 ENOG4105MQ3 flagellar protein FliS HEC60_08595 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HEC60_08600 ENOG4105E5K Alpha-amylase HEC60_08605 ENOG4108W9D (LipO)protein HEC60_08625 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HEC60_08655 ENOG4105E5H Transposase HEC60_08660 ENOG4108YXQ IS66 Orf2 family protein HEC60_08820 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HEC60_08850 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HEC60_08855 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HEC60_08965 ENOG4108UUM single-stranded DNA-binding protein HEC60_08995 ENOG41077V0 CPS-53 (KpLE1) prophage HEC60_09025 ENOG4107R08 Integrase HEC60_09030 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HEC60_09035 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HEC60_09040 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HEC60_09045 ENOG41090PJ Flagellar assembly protein HEC60_09050 ENOG4108JIR Flagellum-specific ATP synthase HEC60_09055 ENOG4105GSA Flagellar export protein flij HEC60_09060 ENOG4105WF4 Flagellar hook-length control protein HEC60_09065 ENOG4107ZI8 flagellar basal body-associated protein flil HEC60_09070 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HEC60_09075 ENOG4105DD5 Flagellar motor switch protein HEC60_09080 ENOG4105K0P flagellar biosynthesis protein HEC60_09085 ENOG4105CN7 Flagellar biosynthetic protein FliP HEC60_09090 ENOG4105VS8 Flagellar biosynthetic protein fliq HEC60_09095 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HEC60_09100 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HEC60_09110 ENOG4105YX3 cellular response to acidity HEC60_09120 ENOG4105VNZ cytoplasmic protein HEC60_09125 ENOG4105CKW Inner membrane protein yedI HEC60_09130 ENOG4105FDR Membrane HEC60_09135 ENOG41090BB DNA mismatch endonuclease (vsr) HEC60_09140 ENOG4105DVF Cytosine-specific methyltransferase HEC60_09145 ENOG4105EST Metal Dependent Phosphohydrolase HEC60_09150 ENOG4105FCK Membrane HEC60_09160 ENOG4108F1U ABC transporter HEC60_09165 ENOG4105EHG Permease protein HEC60_09185 ENOG4105HEI LysR family (Transcriptional regulator HEC60_09200 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HEC60_09215 ENOG4105EM7 Selenocysteine-specific translation elongation factor HEC60_09285 ENOG4107RSM transcriptional regulator HEC60_09290 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC60_09295 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC60_09300 ENOG4108UQV Membrane HEC60_09305 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HEC60_09310 ENOG4105CXY transporter HEC60_09320 ENOG4108HF7 Gcn5-related n-acetyltransferase HEC60_09325 ENOG4105CBN LysR family transcriptional regulator HEC60_09380 ENOG41080VW acetyltransferase HEC60_09400 ENOG4108ETY sodium dicarboxylate symporter HEC60_09405 ENOG4105FYV Amp nucleosidase HEC60_09410 ENOG4105DC7 peptidase M24 HEC60_09430 ENOG4105N1F Hnh endonuclease HEC60_09475 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC60_09490 ENOG4105NAE bifunctional deaminase-reductase domain protein HEC60_09500 ENOG4105EQ2 LysR family Transcriptional regulator HEC60_09505 ENOG4107SET aldo keto reductase HEC60_09510 ENOG4105JAB phenazine biosynthesis protein, phzf family HEC60_09515 ENOG4105N0V mono-oxygenase ydhR HEC60_09545 ENOG4108VCD Chaperone HEC60_09550 ENOG4106EAR Fimbrial protein HEC60_09560 ENOG4108PNB DNA-binding transcriptional regulator HEC60_09585 ENOG4107RNH Outer membrane receptor FepA HEC60_09595 ENOG4105CUB amino acid HEC60_09600 ENOG4105CFQ glutamine synthetase HEC60_09605 ENOG4108Z86 Glutamine amidotransferase HEC60_09610 ENOG4107VRI Transcriptional regulator HEC60_09615 ENOG4105C26 Dehydrogenase HEC60_09620 ENOG4105CJP fad dependent oxidoreductase HEC60_09625 ENOG4105UQX Mate efflux family protein HEC60_09640 ENOG4108PXI ErfK YbiS YcfS YnhG HEC60_09655 ENOG4105D4P Coproporphyrinogen iii oxidase HEC60_09660 ENOG41090JE Utilization Protein HEC60_09670 ENOG4105EHG Permease protein HEC60_09675 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HEC60_09700 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HEC60_09705 ENOG4108YZT Adenosylcobinamide kinase HEC60_09715 ENOG41090HJ UPF0265 protein HEC60_09720 ENOG4105DR8 Membrane HEC60_09730 ENOG4105DZ1 carboxypeptidase HEC60_09735 ENOG4105CJB Exodeoxyribonuclease I HEC60_09740 ENOG4105CUB amino acid HEC60_09750 ENOG4105EQ1 Transcriptional regulator HEC60_09755 ENOG4107SRH Nad-dependent epimerase dehydratase HEC60_09770 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HEC60_09775 ENOG4105CIH Imidazole acetol-phosphate transaminase HEC60_09780 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HEC60_09785 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HEC60_09790 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HEC60_09800 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HEC60_09820 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HEC60_09835 ENOG4105D7W serine acetyltransferase HEC60_09845 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HEC60_09860 ENOG4107UKG Glycosyl transferase, family 4 HEC60_09870 ENOG4105C1B dTDP-glucose 4-6-dehydratase HEC60_09875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HEC60_09880 ENOG4105G1A colanic acid biosynthesis protein HEC60_09885 ENOG4107T8Q Glycosyl transferase (Group 1 HEC60_09890 ENOG4105C74 pyruvyl transferase HEC60_09895 ENOG4105PSV Polysaccharide Biosynthesis Protein HEC60_09900 ENOG4105D3Q Sugar transferase HEC60_09905 ENOG4107QKV phosphomannomutase HEC60_09910 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HEC60_09915 ENOG4106CD9 glycosyl transferase group 1 HEC60_09920 ENOG4105FGF GDP-mannose mannosyl hydrolase HEC60_09925 ENOG4105C30 Nad-dependent epimerase dehydratase HEC60_09930 ENOG4105C0K Gdp-mannose 4,6-dehydratase HEC60_09935 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HEC60_09940 ENOG4105ECJ Glycosyl Transferase HEC60_09945 ENOG4108NYJ Colanic acid HEC60_09950 ENOG4107RXY Glycosyl transferase HEC60_09955 ENOG41090RK glycosyl transferase HEC60_09960 ENOG4105D75 Capsular exopolysaccharide family HEC60_09965 ENOG4105KJF protein tyrosine phosphatase HEC60_09970 ENOG4105DAY polysaccharide export protein HEC60_09975 ENOG4105EE5 Membrane protein terC HEC60_09980 ENOG4108GAE asmA family HEC60_09990 ENOG4105DBI uridine monophosphokinase HEC60_09995 ENOG4105BZU Histidine kinase HEC60_10000 ENOG4105D03 DNA-3-methyladenine glycosylase II HEC60_10005 ENOG4105R8A Heat shock protein HEC60_10015 ENOG4105ENT Efflux transporter rnd family, mfp subunit HEC60_10030 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC60_10035 ENOG4105EB3 Histidine kinase HEC60_10040 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC60_10045 ENOG4105CFP Peptidase U32 HEC60_10060 ENOG4108TC1 Transcriptional regulator HEC60_10065 ENOG4105GQR Chaperone HEC60_10090 ENOG4105EIE fructose-bisphosphate aldolase HEC60_10095 ENOG4105EAA nucleoside HEC60_10100 ENOG4108KD5 ADP-ribosylation crystallin J1 HEC60_10105 ENOG4108TFM Kinase, PfkB family HEC60_10110 ENOG4105FDP GntR family transcriptional regulator HEC60_10115 ENOG4105DWF phosphomethylpyrimidine kinase HEC60_10140 ENOG41082CG Protein CrcB homolog HEC60_10150 ENOG4105CPN adenine deaminase HEC60_10155 ENOG4105C7N Xanthine uracil vitamin C permease HEC60_10160 ENOG4105EJC lysr family transcriptional regulator HEC60_10165 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HEC60_10170 ENOG4105D1F ATP-binding protein HEC60_10180 ENOG4108W15 Protein of unknown function (DUF1456) HEC60_10195 ENOG4108NEV two component transcriptional regulator, LytTR family HEC60_10200 ENOG4108HRK Histidine kinase HEC60_10205 ENOG4108XDN Transcriptional regulator HEC60_10215 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HEC60_10220 ENOG4108IJ8 ABC transporter HEC60_10225 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HEC60_10230 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HEC60_10235 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HEC60_10240 ENOG4105CXG d-lactate dehydrogenase HEC60_10250 ENOG41061WM D-Alanyl-D-Alanine HEC60_10255 ENOG41069YE inner membrane protein yohC HEC60_10260 ENOG4105KHU inner membrane protein YohD HEC60_10270 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HEC60_10275 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HEC60_10280 ENOG4105VAW lrga family HEC60_10285 ENOG41067MG lrgb family HEC60_10290 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HEC60_10295 ENOG4107GZ4 SanA protein HEC60_10300 ENOG4107SDZ Galactoside transport system permease protein mglC HEC60_10305 ENOG4105C2J ABC transporter HEC60_10315 ENOG41060NJ transcriptional regulator HEC60_10320 ENOG4105DHF Membrane HEC60_10325 ENOG4105EUJ GTP cyclohydrolase i HEC60_10330 ENOG4105CBP Major Facilitator HEC60_10340 ENOG4105D05 Receptor HEC60_10345 ENOG4108IQI permease HEC60_10350 ENOG4105DUM transcriptional regulator, lysR family HEC60_10355 ENOG4105HMI Membrane HEC60_10375 ENOG4105DM4 PTS System HEC60_10380 ENOG4105DE4 1-phosphofructokinase HEC60_10385 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HEC60_10390 ENOG4105S8Q sugar efflux transporter HEC60_10395 ENOG4108W3Q Transcriptional regulator HEC60_10400 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HEC60_10405 ENOG4105KRS Proteinase inhibitor HEC60_10415 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HEC60_10420 ENOG4105DEI Mannitol dehydrogenase HEC60_10425 ENOG4105CKI cobalamin synthesis protein HEC60_10430 ENOG41076MN Phosphoesterase, PA-phosphatase related HEC60_10435 ENOG4107TT5 NLP P60 protein HEC60_10440 ENOG4105CXC rtn protein HEC60_10445 ENOG4105E43 Extracellular solute-binding protein, family 5 HEC60_10450 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HEC60_10455 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HEC60_10460 ENOG4108JQ5 ABC transporter HEC60_10465 ENOG4105HG6 HEC60_10470 ENOG4105C2C drug resistance transporter, Bcr CflA HEC60_10475 ENOG4105I08 Pseudouridine synthase HEC60_10480 ENOG4105CFI type iii restriction protein res subunit HEC60_10495 ENOG4105PAN UPF0352 protein HEC60_10500 ENOG4105E68 Sulfatase HEC60_10510 ENOG4105HDK L-asparaginase HEC60_10525 ENOG4105CHH sulfate transporter HEC60_10530 ENOG4105CJW magnesium transporter HEC60_10535 ENOG4105IBP Cyclic peptide transporter HEC60_10540 ENOG4105CF1 Alkylated DNA repair protein HEC60_10545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HEC60_10555 ENOG4105FCK Membrane HEC60_10560 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HEC60_10565 ENOG41068CG regulatoR HEC60_10570 ENOG4105BZU Histidine kinase HEC60_10595 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC60_10605 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC60_10610 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC60_10615 ENOG4105XPH Ferredoxin HEC60_10620 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HEC60_10625 ENOG4105CXY transporter HEC60_10630 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HEC60_10635 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HEC60_10640 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HEC60_10645 ENOG4108EWA cinA-like protein HEC60_10650 ENOG4108UII YfaZ family HEC60_10655 ENOG4105DHQ Histidine kinase HEC60_10680 ENOG4105CEY Amp-dependent synthetase and ligase HEC60_10685 ENOG4105DNI Converts SHCHC to OSB (By similarity) HEC60_10690 ENOG4108IPT Naphthoate synthase HEC60_10695 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HEC60_10705 ENOG4105E4F Isochorismate synthase HEC60_10710 ENOG4105TNS Conserved Protein HEC60_10715 ENOG4107YB6 acetyltransferase, (GNAT) family HEC60_10730 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC60_10735 ENOG4105C8S subunit m HEC60_10740 ENOG4105D65 subunit l HEC60_10745 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC60_10750 ENOG4107UFS subunit j HEC60_10760 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HEC60_10765 ENOG4108IEH NADH dehydrogenase subunit g HEC60_10770 ENOG4107QIZ NADH dehydrogenase HEC60_10775 ENOG4105GKE subunit e HEC60_10780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC60_10785 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC60_10790 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HEC60_10795 ENOG4107NQ8 LysR family Transcriptional regulator HEC60_10800 ENOG4105CHM Aminotransferase HEC60_10805 ENOG4105DK2 UPF0207 protein HEC60_10810 ENOG4107QWE )-transporter HEC60_10815 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HEC60_10830 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HEC60_10835 ENOG4105C6K Malic enzyme HEC60_10845 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEC60_10850 ENOG4108HHA Transketolase HEC60_10855 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HEC60_10865 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HEC60_10870 ENOG4105K2J Transcriptional regulator HEC60_10875 ENOG4105PTV Nudix Hydrolase HEC60_10880 ENOG4108RE9 Phosphodiesterase HEC60_10885 ENOG4108SHQ Glutathione S-transferase HEC60_10890 ENOG4105CYM Glutathione S-transferase HEC60_10895 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HEC60_10900 ENOG4105ECP epimerase HEC60_10920 ENOG4108JEH abc transporter atp-binding protein HEC60_10925 ENOG4106YG3 ABC transporter HEC60_10930 ENOG4105DSP amino acid AbC transporter HEC60_10935 ENOG4105E89 ABC transporter HEC60_10940 ENOG4105E89 ABC transporter HEC60_10945 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HEC60_10950 ENOG4108IQI permease HEC60_10955 ENOG4106M28 alanine racemase domain protein HEC60_10960 ENOG4105E5D amino acid HEC60_10965 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HEC60_10970 ENOG4108JUB Transcriptional regulator HEC60_10975 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HEC60_10980 ENOG4105E96 Colicin v production protein HEC60_10985 ENOG4108S3P Sporulation domain protein HEC60_10990 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HEC60_10995 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HEC60_11000 ENOG4105DQR SNARE associated Golgi HEC60_11005 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HEC60_11010 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HEC60_11020 ENOG4106WZ1 flagella biosynthesis regulator HEC60_11025 ENOG4105F9N Major Facilitator Superfamily HEC60_11030 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC60_11040 ENOG4105ID8 Transcriptional regulator, ARAC family HEC60_11050 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HEC60_11055 ENOG4105EP8 Glycosyl Hydrolase Family 88 HEC60_11065 ENOG4105MH2 YfcL protein HEC60_11070 ENOG4108BPE -transporting atpase HEC60_11075 ENOG4105EJ9 Membrane HEC60_11080 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HEC60_11085 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HEC60_11090 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HEC60_11095 ENOG4108DG9 Smr protein MutS2 HEC60_11100 ENOG4108BY2 phosphohistidine phosphatase HEC60_11105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEC60_11110 ENOG4105CHU acetyl-coa acetyltransferase HEC60_11115 ENOG4105KZW UPF0381 protein HEC60_11120 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HEC60_11125 ENOG410903C (LipO)protein HEC60_11135 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HEC60_11210 ENOG4105CS6 Rhs element vgr protein HEC60_11225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC60_11235 ENOG4108ZG0 Ompa motb domain protein HEC60_11260 ENOG4105DND Transcriptional regulator HEC60_11265 ENOG4107B2H carbonic anhydrase HEC60_11275 ENOG4105DJ2 Major Facilitator Superfamily HEC60_11285 ENOG4105CHM Aminotransferase HEC60_11290 ENOG4108HRK Histidine kinase HEC60_11295 ENOG4105DY9 regulatoR HEC60_11300 ENOG4105CHC glucokinase (EC 2.7.1.2) HEC60_11310 ENOG4107RA9 decarboxylase HEC60_11315 ENOG4109076 Conserved Protein HEC60_11330 ENOG4105D9N nucleoside HEC60_11335 ENOG4108KMM Diguanylate cyclase HEC60_11350 ENOG4105HZG regulatoR HEC60_11355 ENOG4105GXM Putative transcription regulator (DUF1323) HEC60_11390 ENOG4108M0I Transcriptional regulator HEC60_11395 ENOG4105DHU Bile acid HEC60_11400 ENOG4105VRT cytoplasmic protein HEC60_11405 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HEC60_11415 ENOG4105EXN Sulfate transport protein CysZ HEC60_11420 ENOG4105C6T cysteine synthase HEC60_11430 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HEC60_11435 ENOG4105C5Y PTS System HEC60_11445 ENOG4105C6T cysteine synthase HEC60_11450 ENOG4108IJ6 ABC transporter HEC60_11455 ENOG4105ECW sulfate abc transporter HEC60_11460 ENOG4108I5D sulfate abc transporter HEC60_11465 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HEC60_11470 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HEC60_11475 ENOG4105EZR dyp-type peroxidase family protein HEC60_11480 ENOG4105E7K (LipO)protein HEC60_11485 ENOG4105QZU Inner membrane protein YfeZ HEC60_11490 ENOG4108R6G acetyltransferase HEC60_11495 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HEC60_11520 ENOG4105KNY Microcompartments protein HEC60_11525 ENOG4105KNY Microcompartments protein HEC60_11530 ENOG4105KNY Microcompartments protein HEC60_11535 ENOG4105C0A alcohol dehydrogenase HEC60_11545 ENOG4105C0A alcohol dehydrogenase HEC60_11550 ENOG4105C6N Formate acetyltransferase HEC60_11555 ENOG4105F1A Pyruvate formate-lyase HEC60_11560 ENOG4105KNY Microcompartments protein HEC60_11565 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HEC60_11585 ENOG4108K3Z AraC family transcriptional regulator HEC60_11590 ENOG4108X49 Ethanolamine utilization protein EutK HEC60_11595 ENOG4106D67 ethanolamine utilization protein HEC60_11605 ENOG4105CPD ethanolamine ammonia-lyase HEC60_11610 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HEC60_11615 ENOG4105ENY Ethanolamine utilization protein eutH HEC60_11620 ENOG4105C0A alcohol dehydrogenase HEC60_11625 ENOG4108EKI Dehydrogenase HEC60_11630 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HEC60_11635 ENOG4105KNY Microcompartments protein HEC60_11640 ENOG4107WUY phosphate acetyltransferase HEC60_11645 ENOG4105NDK ethanolamine utilization protein HEC60_11650 ENOG4106S4J ethanolamine utilization protein EutP HEC60_11655 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HEC60_11660 ENOG4105C6K Malic enzyme HEC60_11665 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEC60_11670 ENOG4108PVD exported protein HEC60_11675 ENOG4107VIJ nudix hydrolase HEC60_11680 ENOG4105BZS acriflavin resistance protein HEC60_11690 ENOG4105KUZ arsenate reductase HEC60_11695 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HEC60_11705 ENOG4106KED esterase YpfH HEC60_11710 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HEC60_11715 ENOG4105CGZ zinc metallopeptidase HEC60_11720 ENOG4105C8V SAICAR synthetase HEC60_11725 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC60_11730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEC60_11735 ENOG4105RH4 Glycine cleavage system transcriptional repressor HEC60_11740 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEC60_11745 ENOG4105BZW Glycerate kinase HEC60_11750 ENOG4107QQ0 gntp family HEC60_11755 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HEC60_11760 ENOG4105C02 permease HEC60_11765 ENOG4105ERG peptidase m48, ste24p HEC60_11770 ENOG4105K89 arsenate reductase HEC60_11790 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HEC60_11800 ENOG4105C2W permease HEC60_11810 ENOG4105CS2 ec 3.2.1.21 HEC60_11820 ENOG4108V3E phosphoribosylglycinamide formyltransferase HEC60_11830 ENOG4105C9X ppx gppa phosphatase HEC60_11835 ENOG4105BZU Histidine kinase HEC60_11840 ENOG41062G3 Protein of unknown function (DUF2633) HEC60_11850 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HEC60_11855 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEC60_11860 ENOG4105VPD cellular component movement HEC60_11865 ENOG4105DUX Transporter HEC60_11870 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HEC60_11875 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC60_11880 ENOG4105N21 Membrane HEC60_11900 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HEC60_11905 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HEC60_11910 ENOG4108JQB penicillin-binding protein 1C HEC60_11915 ENOG4105DN3 alpha-2-macroglobulin domain protein HEC60_11920 ENOG4105KHC sulfurtransferase HEC60_11925 ENOG4105YYA enhanced serine sensitivity protein SseB HEC60_11930 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HEC60_11935 ENOG4105WVQ Fe-S assembly protein IscX HEC60_11940 ENOG4108ZIT Ferredoxin, 2FE-2S HEC60_11955 ENOG4108Z4V iron-sulfur cluster assembly HEC60_11960 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HEC60_11970 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HEC60_11975 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HEC60_11980 ENOG4105ECY inositol monophosphatase HEC60_11985 ENOG4105D7X high-affinity nickel-transporter HEC60_11990 ENOG41065CD Exported protein HEC60_11995 ENOG4108MN2 Stationary phase inducible protein CsiE HEC60_12000 ENOG4105ETE Transcriptional regulator (LacI family HEC60_12005 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEC60_12015 ENOG4105D8G Major Facilitator superfamily HEC60_12025 ENOG4107QNK )-transporter HEC60_12030 ENOG4107HQ7 repeat protein HEC60_12035 ENOG4108NZE NAGC-like transcriptional regulator HEC60_12045 ENOG4105C2J ABC transporter HEC60_12050 ENOG4105CNN ABC, transporter HEC60_12060 ENOG4105EF1 ribulokinase HEC60_12065 ENOG4105C2X Arabinose 5-phosphate isomerase HEC60_12070 ENOG4108SB3 DoxX Family HEC60_12075 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HEC60_12080 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HEC60_12085 ENOG4108YZA Nitrogen regulatory protein pii HEC60_12090 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC60_12095 ENOG4108SKK alpha helix protein HEC60_12100 ENOG4107WP9 Histidine kinase HEC60_12105 ENOG4108ETH Formylglycinamide ribotide synthetase HEC60_12115 ENOG4108Z6B deaminase HEC60_12120 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HEC60_12125 ENOG4106G6Q Transcriptional regulator HEC60_12130 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HEC60_12140 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HEC60_12145 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HEC60_12150 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HEC60_12155 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HEC60_12160 ENOG4105C3F Signal peptidase i HEC60_12165 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HEC60_12170 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HEC60_12175 ENOG4105VQK sigma E regulatory protein, MucB RseB HEC60_12180 ENOG41069PW sigma-e factor negative regulatory protein HEC60_12195 ENOG4108IYU L-aspartate oxidase HEC60_12200 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HEC60_12205 ENOG4105C1J atp-dependent rna helicase HEC60_12220 ENOG4105EIB trna rrna methyltransferase HEC60_12225 ENOG4105K63 Thioredoxin HEC60_12230 ENOG4106IUH DTW domain containing protein HEC60_12235 ENOG4105CD5 CoA-binding domain protein HEC60_12240 ENOG4105JIM Phosphatidylserine synthase HEC60_12245 ENOG4105CSH Transporter HEC60_12265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HEC60_12270 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HEC60_12275 ENOG4105C34 Pseudouridine synthase HEC60_12280 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HEC60_12285 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HEC60_12295 ENOG4105CQC Prephenate dehydratase HEC60_12300 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HEC60_12305 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HEC60_12310 ENOG4105QP9 Protein of unknown function (DUF2799) HEC60_12315 ENOG4108WS1 HEC60_12320 ENOG4108KHX Diguanylate cyclase HEC60_12325 ENOG41090EK ompa motb domain protein HEC60_12380 ENOG4105KSC Transcriptional regulator, TraR DksA family HEC60_12415 ENOG4105ED4 portal protein HEC60_12510 ENOG4105PTU response to oxidative stress HEC60_12550 ENOG4105ZTC transcriptional activator, Ogr delta HEC60_12570 ENOG4105K5M 30s ribosomal protein S16 HEC60_12575 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HEC60_12580 ENOG4106KVJ cytochrome C assembly protein HEC60_12585 ENOG4108JU6 CBS domain protein HEC60_12600 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HEC60_12605 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HEC60_12610 ENOG4105VDB UPF0125 protein HEC60_12615 ENOG4108Z1B Cyclase dehydrase HEC60_12650 ENOG4105W7K Transcriptional regulator HEC60_12695 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HEC60_12715 ENOG4107QHF type ii secretion system protein e HEC60_12745 ENOG4108NIW Leucine export protein LeuE HEC60_12750 ENOG4105EW9 transcriptional regulator AsnC family HEC60_12755 ENOG4105ECQ AraC Family Transcriptional Regulator HEC60_12805 ENOG4105CI2 imidazolone-5-propionate hydrolase HEC60_12815 ENOG4105CN8 Transcriptional regulator HEC60_12820 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HEC60_12825 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HEC60_12835 ENOG4105J12 Multidrug resistance protein mdtN HEC60_12840 ENOG4108MI0 Resistance protein HEC60_12845 ENOG4105ETP RND efflux system, outer membrane lipoprotein HEC60_12850 ENOG4105VR1 Pfam:DUF1271 HEC60_12855 ENOG410830R acetyltransferase HEC60_12885 ENOG4105E82 cytochrome subunit of dehydrogenase HEC60_12890 ENOG4105DH8 myo-inositol catabolism HEC60_12900 ENOG4105D7K pfkb domain protein HEC60_12905 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HEC60_12910 ENOG4105CNN ABC, transporter HEC60_12915 ENOG4105C2J ABC transporter HEC60_12920 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEC60_12930 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HEC60_12935 ENOG4105C26 Dehydrogenase HEC60_12945 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_12950 ENOG4105DZC cytosine deaminase HEC60_12955 ENOG4105C5B carbamate kinase HEC60_12965 ENOG4107REC cytoplasmic protein HEC60_12970 ENOG4107R1Q Membrane protein FdrA HEC60_12975 ENOG4105N16 Protein of unknown function (DUF2877) HEC60_12980 ENOG4107SNB ankyrin repeat protein YahD HEC60_12985 ENOG4108NUU Transcriptional regulator HEC60_12990 ENOG4105VPI YqaE family transport protein HEC60_12995 ENOG41080HT Transcriptional regulator, arsr family HEC60_13000 ENOG4108V62 Rhodanese domain protein HEC60_13005 ENOG4108X73 DNA- binding protein HEC60_13010 ENOG4108RNS Exports L-alanine (By similarity) HEC60_13015 ENOG4108WMJ Protein of unknown function (DUF2002) HEC60_13020 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HEC60_13030 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HEC60_13035 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HEC60_13045 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC60_13050 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HEC60_13055 ENOG4108IJ7 Glycine betaine HEC60_13060 ENOG4108HQS Glycine betaine HEC60_13065 ENOG4105GIJ Glycine betaine HEC60_13070 ENOG4105EQ0 Major Facilitator superfamily HEC60_13075 ENOG4105NTK Transcriptional repressor Mpra HEC60_13080 ENOG4105CW7 secretion protein, HlyD family HEC60_13085 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC60_13100 ENOG4105W39 Membrane HEC60_13105 ENOG4107VXZ Hydrolase HEC60_13110 ENOG4105K3G Periplasmic Protein HEC60_13140 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HEC60_13150 ENOG4105Y3E Modulates RecA activity (By similarity) HEC60_13160 ENOG4107TH8 cina domain protein HEC60_13165 ENOG4105DSE periplasmic solute binding protein HEC60_13170 ENOG4105CC5 ABC transporter HEC60_13175 ENOG4105DIK (ABC) transporter HEC60_13180 ENOG4105CVE Lytic murein transglycosylase HEC60_13185 ENOG4105C2X Arabinose 5-phosphate isomerase HEC60_13215 ENOG4105C8H hydrogenase maturation protein Hypf HEC60_13220 ENOG4108RC0 Electron transport protein HEC60_13225 ENOG4105DDV Transcriptional regulator (LacI family HEC60_13235 ENOG4105CS2 ec 3.2.1.21 HEC60_13240 ENOG4108MG9 hydrogenase 3 maturation protease HEC60_13245 ENOG4108JUA Transcriptional regulator HEC60_13250 ENOG4105I6X formate hydrogenlyase maturation HEC60_13255 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HEC60_13265 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HEC60_13270 ENOG4108JPZ Monovalent cation H antiporter subunit D HEC60_13275 ENOG4107WQX hydrogenase 4 membrane subunit HEC60_13280 ENOG4105D65 subunit l HEC60_13285 ENOG4107TDF Formate hydrogenlyase subunit 4 HEC60_13290 ENOG4108JPZ Monovalent cation H antiporter subunit D HEC60_13295 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HEC60_13305 ENOG4107RSS Hydrogenase accessory protein HypB HEC60_13310 ENOG41083WG hydrogenase assembly chaperone HEC60_13315 ENOG4105CQS hydrogenase expression formation protein HypD HEC60_13320 ENOG4105C45 hydrogenase expression formation protein (HypE) HEC60_13335 ENOG4105VXR cytoplasmic protein HEC60_13345 ENOG4107RSM transcriptional regulator HEC60_13355 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HEC60_13370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC60_13375 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HEC60_13380 ENOG4105JQN Transcriptional regulator HEC60_13385 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC60_13410 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HEC60_13415 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HEC60_13430 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HEC60_13435 ENOG4105N0Z inner membrane protein ygbE HEC60_13440 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) HEC60_13450 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HEC60_13455 ENOG4108MXK alkaline phosphatase isozyme conversion HEC60_13460 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HEC60_13475 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HEC60_13480 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HEC60_13485 ENOG4105WQV ferredoxin-like protein HEC60_13490 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HEC60_13495 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HEC60_13500 ENOG4106IKH Electron transfer flavoprotein HEC60_13505 ENOG4105C54 Major Facilitator superfamily HEC60_13510 ENOG4107R3A FAD linked oxidase domain protein HEC60_13515 ENOG4105CHR reductase HEC60_13520 ENOG4108ITV Inner membrane protein yqcE HEC60_13525 ENOG4108CWB sugar kinase ygcE HEC60_13530 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HEC60_13535 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HEC60_13540 ENOG4105CI1 PTS System HEC60_13555 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HEC60_13560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HEC60_13565 ENOG4105DXN mazG family HEC60_13570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEC60_13580 ENOG4105BZU Histidine kinase HEC60_13585 ENOG4105QDK Flavodoxin HEC60_13590 ENOG4105DR9 pseudouridine synthase HEC60_13595 ENOG4105WP7 tRNA pseudouridine synthase C HEC60_13600 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HEC60_13610 ENOG4105EWT decarboxylase family HEC60_13615 ENOG4105C44 Serine transporter HEC60_13620 ENOG4105EJQ L-serine dehydratase HEC60_13635 ENOG4105M08 Membrane HEC60_13640 ENOG4105ETT transcriptional Regulator, LysR family HEC60_13645 ENOG4105C9B Cysteine desulfurase HEC60_13650 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HEC60_13655 ENOG4105CUZ uba thif-type nad fad binding protein HEC60_13660 ENOG4105CA3 membrane-bound lytic murein transglycosylase HEC60_13675 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEC60_13680 ENOG4107QZM n-acetylglutamate synthase HEC60_13685 ENOG4107QYX exodeoxyribonuclease v alpha HEC60_13695 ENOG4107QXK peptidase HEC60_13700 ENOG4105DSY exodeoxyribonuclease V, gamma HEC60_13705 ENOG4105RVB Prepilin peptidase dependent protein c HEC60_13710 ENOG4105SEN Protein of unknown function (DUF2509) HEC60_13715 ENOG4105JCS prepilin peptidase dependent protein HEC60_13720 ENOG4105IPU prepilin peptidase dependent protein A HEC60_13725 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HEC60_13730 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HEC60_13735 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HEC60_13755 ENOG4105EE5 Membrane protein terC HEC60_13760 ENOG4105SUV lipoprotein YgdR HEC60_13765 ENOG4105CPC Aldo Keto reductase HEC60_13770 ENOG4107S74 Lysophospholipid transporter LplT HEC60_13775 ENOG4105CEY Amp-dependent synthetase and ligase HEC60_13780 ENOG41060NJ transcriptional regulator HEC60_13790 ENOG4105DDV Transcriptional regulator (LacI family HEC60_13800 ENOG4105RQF LysR family Transcriptional regulator HEC60_13810 ENOG4108QY5 Ferric enterobactin transport protein HEC60_13815 ENOG4105CHR reductase HEC60_13825 ENOG4105CHU acetyl-coa acetyltransferase HEC60_13830 ENOG4105DUM transcriptional regulator, lysR family HEC60_13840 ENOG4108MHD transport protein HEC60_13845 ENOG4107S5I aldo keto reductase HEC60_13865 ENOG4108VCD Chaperone HEC60_13870 ENOG4105CW0 outer membrane usher protein HEC60_13885 ENOG4105DUX Transporter HEC60_13890 ENOG4105CXN decarboxylase HEC60_13895 ENOG4105D5Q Arginine ornithine antiporter HEC60_13900 ENOG4108M3R transcriptional activator CadC HEC60_13935 ENOG4108K5P (LipO)protein HEC60_13955 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HEC60_13960 ENOG4105T95 Thiol disulfide interChange protein HEC60_13965 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC60_13975 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HEC60_13980 ENOG4105Y75 tpr repeat protein HEC60_13990 ENOG4108UT2 hemolysin iii HEC60_13995 ENOG4105N5Z UPF0267 protein HEC60_14000 ENOG4108Q3X Transcriptional regulator HEC60_14005 ENOG4105CS2 ec 3.2.1.21 HEC60_14015 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HEC60_14020 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HEC60_14025 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HEC60_14030 ENOG4105D0A hydroxylase HEC60_14035 ENOG4107RAQ aminopeptidase HEC60_14045 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HEC60_14055 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HEC60_14060 ENOG4108JQ1 Dehydrogenase HEC60_14065 ENOG4105E66 phosphoriboisomerase A HEC60_14075 ENOG4105D5P Methylmalonyl-coA mutase HEC60_14080 ENOG4105DJT lAO AO transport system ATPase HEC60_14085 ENOG4108M7F enoyl-CoA hydratase isomerase HEC60_14090 ENOG4105CYC Transferase HEC60_14095 ENOG4105DEQ transcriptional regulator HEC60_14100 ENOG4105MPN Membrane HEC60_14110 ENOG4105D64 Mechanosensitive ion channel HEC60_14115 ENOG4107653 Transcriptional regulator HEC60_14125 ENOG4107REC cytoplasmic protein HEC60_14130 ENOG4107R1Q Membrane protein FdrA HEC60_14140 ENOG4105C5B carbamate kinase HEC60_14145 ENOG4105D2N Aldolase HEC60_14150 ENOG4105BZA Phosphoglycerate kinase HEC60_14160 ENOG4105CV1 Transketolase (EC 2.2.1.1) HEC60_14165 ENOG4108K0D peptidase, M48 HEC60_14170 ENOG4105C7K acetolactate synthase HEC60_14180 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HEC60_14185 ENOG4105CHR reductase HEC60_14190 ENOG4108MXF Alpha Beta Hydrolase HEC60_14215 ENOG4108FUF Transcriptional regulator, IclR family HEC60_14220 ENOG4105CHR reductase HEC60_14240 ENOG4105CYW agmatinase HEC60_14255 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HEC60_14270 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HEC60_14285 ENOG4107QNK )-transporter HEC60_14290 ENOG4105GPY SprT protein HEC60_14295 ENOG4105RWS endonuclease I HEC60_14300 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HEC60_14305 ENOG4105D7Z glutathione synthase HEC60_14320 ENOG41086KC Transcriptional regulator HEC60_14325 ENOG4105CZX twitching motility protein HEC60_14330 ENOG4105DFA alanine racemase domain protein HEC60_14335 ENOG4108VIA integral membrane protein HEC60_14340 ENOG4105VZ9 UPF0235 protein HEC60_14345 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEC60_14350 ENOG4105CSA Coproporphyrinogen iii oxidase HEC60_14355 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HEC60_14360 ENOG4105K33 Periplasmic Protein HEC60_14365 ENOG41090ED Protein with unknown function (DUF469) HEC60_14375 ENOG4105CEN a g-specific adenine glycosylase HEC60_14380 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HEC60_14390 ENOG4105EAA nucleoside HEC60_14395 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HEC60_14405 ENOG4105CHY citrate lyase, alpha HEC60_14410 ENOG4105CI0 Citrate lyase HEC60_14415 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HEC60_14420 ENOG4105DUA (citrate (pro-3S)-lyase ligase HEC60_14425 ENOG4105ERH Fumarylacetoacetate hydrolase HEC60_14430 ENOG4105D2K citrate carrier protein HEC60_14435 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HEC60_14440 ENOG4106YYS transcriptional regulatory protein HEC60_14445 ENOG4105CXN decarboxylase HEC60_14450 ENOG4108UQV Membrane HEC60_14485 ENOG410839U amino acid HEC60_14490 ENOG4108JUB Transcriptional regulator HEC60_14500 ENOG4105D2S major facilitator superfamily HEC60_14505 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HEC60_14515 ENOG4105CN8 Transcriptional regulator HEC60_14520 ENOG4106032 Glutathionylspermidine synthase HEC60_14530 ENOG4105CYM Glutathione S-transferase HEC60_14535 ENOG410900S Protein of unknown function (DUF2623) HEC60_14540 ENOG4105CPC Aldo Keto reductase HEC60_14545 ENOG4105C87 Aminotransferase class I and II HEC60_14550 ENOG4105DFD Na H antiporter HEC60_14555 ENOG41060NJ transcriptional regulator HEC60_14575 ENOG4108ZZF transport protein (ExbD) HEC60_14580 ENOG4105CWK Biopolymer transport protein, ExbB HEC60_14585 ENOG4105C28 cystathionine HEC60_14590 ENOG4108K81 inner membrane protein YghB HEC60_14595 ENOG4105CF7 AraC family transcriptional regulator HEC60_14600 ENOG4108I6A alcohol dehydrogenase HEC60_14605 ENOG4105CV8 reductase HEC60_14610 ENOG4105CCT upf0313 protein HEC60_14615 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HEC60_14620 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HEC60_14625 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC60_14630 ENOG4105F4I Transcriptional regulator HEC60_14635 ENOG4105H4F exported protein HEC60_14640 ENOG4105XJC Two component transcriptional regulator (Winged helix family HEC60_14645 ENOG4105DHQ Histidine kinase HEC60_14650 ENOG4105NF4 modulator of drug activity HEC60_14655 ENOG4105VRH Antibiotic biosynthesis monooxygenase HEC60_14660 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC60_14665 ENOG4105IPS esterase HEC60_14670 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HEC60_14675 ENOG4108SX3 cytoplasmic protein HEC60_14680 ENOG41087AY ADP-Ribose pyrophosphatase HEC60_14685 ENOG4105DFG type I secretion outer membrane protein HEC60_14695 ENOG4106032 Glutathionylspermidine synthase HEC60_14700 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HEC60_14705 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HEC60_14710 ENOG4105W0Z cytoplasmic protein HEC60_14720 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HEC60_14730 ENOG4105I7R Adenylate cyclase HEC60_14735 ENOG4106MWK domain protein HEC60_14740 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HEC60_14750 ENOG4107ZVW dihydroneopterin aldolase HEC60_14770 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HEC60_14775 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC60_14795 ENOG4108VCA G U mismatch-specific DNA glycosylase HEC60_14810 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HEC60_14830 ENOG4105D01 (LipO)protein HEC60_14835 ENOG4108UMI ABC transporter, permease HEC60_14840 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEC60_14850 ENOG4105C28 cystathionine HEC60_14860 ENOG4105Q26 Siderophore-interacting protein HEC60_14865 ENOG4105NTW Transcriptional regulator HEC60_14870 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_14875 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HEC60_14885 ENOG4105C8Y Acetylornithine aminotransferase HEC60_14890 ENOG4108Y51 tRNA-binding protein HEC60_14895 ENOG4105CQ4 Transcriptional regulator HEC60_14900 ENOG4105CNT hydrolase family 2 HEC60_14905 ENOG4105FK9 beta-D-galactosidase beta subunit HEC60_14910 ENOG4105E5D amino acid HEC60_14915 ENOG4107W6W Conserved Protein HEC60_14920 ENOG4107WCA isomerase HEC60_14925 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HEC60_14930 ENOG41061GT Aldolase HEC60_14935 ENOG4105D4B ABC, transporter HEC60_14940 ENOG4105F5R ABC transporter HEC60_14945 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HEC60_14950 ENOG4105C2J ABC transporter HEC60_14955 ENOG4105DKT Transcriptional regulator HEC60_14960 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HEC60_14975 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HEC60_14980 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HEC60_14985 ENOG4108VKG metal-dependent hydrolase HEC60_14990 ENOG4105EE0 oxidoreductase HEC60_14995 ENOG4105DU1 integral membrane protein, terc HEC60_15000 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HEC60_15005 ENOG4105CTX dehydratase HEC60_15015 ENOG4105DPW Major facilitator superfamily MFS_1 HEC60_15020 ENOG4107YCY Transcriptional regulator HEC60_15025 ENOG4106W5V Membrane HEC60_15030 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HEC60_15035 ENOG4105WAY exported protein HEC60_15040 ENOG4105NE1 Conserved Protein HEC60_15045 ENOG41090KG Inner membrane protein YqjE HEC60_15050 ENOG4105YJD HEC60_15055 ENOG4108VBZ doxx family HEC60_15060 ENOG4105CHF Glutathione S-transferase HEC60_15065 ENOG4105KAF membrAne HEC60_15070 ENOG4105CWB LysR family transcriptional Regulator HEC60_15075 ENOG4108CNN domain protein HEC60_15080 ENOG4105CEM UPF0597 protein HEC60_15085 ENOG4105C44 Serine transporter HEC60_15095 ENOG4105EJQ L-serine dehydratase HEC60_15100 ENOG4105C6N Formate acetyltransferase HEC60_15115 ENOG4105C7B Threonine dehydratase HEC60_15120 ENOG410811B TRANSCRIPTIONal HEC60_15130 ENOG4105E98 transcriptional regulator DeoR family HEC60_15135 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HEC60_15140 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HEC60_15150 ENOG4105F3R pts system mannose fructose sorbose family iid HEC60_15155 ENOG4108YTN IIa component HEC60_15160 ENOG4105CE4 GlcNAc 6-P deacetylase HEC60_15165 ENOG4105E70 isomerase HEC60_15170 ENOG4105D2N Aldolase HEC60_15175 ENOG4105CI1 PTS System HEC60_15180 ENOG4105CHM Aminotransferase HEC60_15190 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HEC60_15195 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HEC60_15200 ENOG41082RQ UPF0102 protein HEC60_15205 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HEC60_15210 ENOG4105W4M Transport-associated protein HEC60_15215 ENOG4107S21 permease HEC60_15220 ENOG4105K4T epimerase HEC60_15230 ENOG41082IR Excinuclease ABC C subunit domain protein HEC60_15235 ENOG4108YYD acetyltransferase HEC60_15255 ENOG4105DEN Luciferase family HEC60_15260 ENOG4105CIC tryptophan-specific transport protein HEC60_15265 ENOG4105C1J atp-dependent rna helicase HEC60_15280 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HEC60_15285 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HEC60_15290 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HEC60_15295 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HEC60_15300 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HEC60_15305 ENOG4105CHV Transcription elongation factor NusA HEC60_15320 ENOG4105CDH Citrulline--aspartate ligase HEC60_15325 ENOG4108PNB DNA-binding transcriptional regulator HEC60_15330 ENOG4105UYK outer membrane protein a HEC60_15335 ENOG4108UII YfaZ family HEC60_15350 ENOG4105NTZ Preprotein translocase subunit SecG HEC60_15355 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HEC60_15360 ENOG4105EEI dihydropteroate synthase HEC60_15365 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HEC60_15370 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HEC60_15375 ENOG4105HBR Rna-binding protein HEC60_15380 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HEC60_15385 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HEC60_15390 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HEC60_15395 ENOG4105QYV Membrane HEC60_15400 ENOG4105K46 50S ribosomal protein l27 HEC60_15405 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HEC60_15410 ENOG4105EAH synthase HEC60_15415 ENOG4105HVQ Regulatory factor of maltose metabolism HEC60_15420 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HEC60_15425 ENOG4105VFK BolA family HEC60_15430 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HEC60_15435 ENOG4105E3I toluene tolerance HEC60_15440 ENOG4107PE3 Mammalian cell entry related domain protein HEC60_15445 ENOG4105CY3 ABC transporter, permease HEC60_15450 ENOG4105DHJ ABC, transporter HEC60_15455 ENOG4105FEU K -dependent Na -Ca exchanger HEC60_15460 ENOG4105C2X Arabinose 5-phosphate isomerase HEC60_15470 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HEC60_15475 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HEC60_15480 ENOG4108IUZ ABC transporter HEC60_15485 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC60_15490 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HEC60_15495 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HEC60_15500 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HEC60_15505 ENOG41080Z8 PHOSPHOCARRIER protein HEC60_15510 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HEC60_15515 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HEC60_15520 ENOG4105BZU Histidine kinase HEC60_15525 ENOG4105N5T Radical SAM Protein HEC60_15530 ENOG4105CBC glutamate synthase HEC60_15535 ENOG4105BZ8 glutamate synthase HEC60_15540 ENOG4108Z33 Thiol disulfide Interchange Protein HEC60_15550 ENOG4105DUM transcriptional regulator, lysR family HEC60_15555 ENOG4108R66 Conserved Protein HEC60_15565 ENOG4105JHE Major Facilitator Superfamily HEC60_15575 ENOG4108QBF Transcriptional regulator HEC60_15580 ENOG4105KB2 stringent starvation protein b HEC60_15585 ENOG4107MKT Stringent starvation protein a HEC60_15595 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HEC60_15600 ENOG4105D6Z AFG1 family ATPase HEC60_15605 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HEC60_15610 ENOG4105C0H protease HEC60_15615 ENOG4105C0H protease HEC60_15625 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HEC60_15630 ENOG4105RID UPF0379 protein yhcN HEC60_15635 ENOG4105RID UPF0379 protein yhcN HEC60_15640 ENOG4105UNR (Barnase) inhibitor HEC60_15650 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HEC60_15660 ENOG4105ZQC membrane protein AaeX HEC60_15665 ENOG4105CR8 Transcriptional regulator HEC60_15670 ENOG4107EDW L-fucose operon activator HEC60_15680 ENOG4105CMG Carbohydrate kinase HEC60_15690 ENOG4105EDR glucose galactose transporter HEC60_15695 ENOG4107W7X Aldolase HEC60_15700 ENOG4105D1U peptidase U62 modulator of DNA gyrase HEC60_15705 ENOG4105QD6 exported protein HEC60_15710 ENOG4105C03 ribonuclease HEC60_15720 ENOG4105VQ7 Rod shape-determining protein MreD HEC60_15725 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HEC60_15740 ENOG41062P1 Diguanylate cyclase phosphodiesterase HEC60_15745 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HEC60_15755 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HEC60_15760 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HEC60_15765 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HEC60_15770 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HEC60_15775 ENOG4105RG0 Membrane HEC60_15780 ENOG4108IA2 Sodium pantothenate symporter HEC60_15785 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HEC60_15800 ENOG41061ME transport protein HEC60_15805 ENOG4105BZU Histidine kinase HEC60_15810 ENOG4108XG4 DNA-binding transcriptional regulator HEC60_15815 ENOG4105C1P efflux transporter, rnd family, mfp subunit HEC60_15820 ENOG4105BZS acriflavin resistance protein HEC60_15825 ENOG4105XCM membrane LIPOPROTEIN HEC60_15835 ENOG4105EZ7 amino acid ABC transporter HEC60_15840 ENOG4105DRP amino acid AbC transporter HEC60_15845 ENOG4105CDA abc transporter atp-binding protein HEC60_15880 ENOG4108Z0R Transferase HEC60_15885 ENOG4105SG3 Protein of unknown function (DUF1488) HEC60_15890 ENOG4105E2X shikimate dehydrogenase HEC60_15895 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HEC60_15900 ENOG4108WI1 Dna topoisomerase HEC60_15910 ENOG4105C79 DNA protecting protein DprA HEC60_15930 ENOG4105C1A potassium transporter peripheral membrane HEC60_15940 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HEC60_15945 ENOG4105W1Y Transcriptional regulator HEC60_15950 ENOG4105VTS DnaJ-like, subfamily C HEC60_15955 ENOG4108ZT0 50S ribosomal protein l17 HEC60_15960 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC60_15965 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HEC60_15970 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HEC60_15975 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HEC60_15980 ENOG41067V7 50S ribosomal protein L36 HEC60_15985 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HEC60_15990 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HEC60_15995 ENOG4105VPB 50S ribosomal protein L30 HEC60_16000 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HEC60_16010 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HEC60_16015 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HEC60_16030 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HEC60_16045 ENOG41083MP 50s ribosomal protein l29 HEC60_16050 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HEC60_16055 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HEC60_16065 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HEC60_16100 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HEC60_16110 ENOG4105GVR general secretion pathway protein D HEC60_16115 ENOG4107QHF type ii secretion system protein e HEC60_16120 ENOG4105D7Q type ii secretion system HEC60_16125 ENOG4108VAU general secretion pathway protein G HEC60_16130 ENOG4105X5Z General secretion pathway protein I HEC60_16140 ENOG4105R04 type II secretion system protein K HEC60_16145 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HEC60_16160 ENOG4108UQY Iron-storage protein HEC60_16165 ENOG4105W53 bacterioferritin-associated ferredoxin HEC60_16180 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HEC60_16185 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HEC60_16200 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HEC60_16210 ENOG4105WWK YheO domain protein HEC60_16215 ENOG4108V1T peptidylprolyl cis-trans isomerase HEC60_16220 ENOG4105VRX Protein slyX homolog HEC60_16225 ENOG4108YZY peptidylprolyl cis-trans isomerase HEC60_16230 ENOG4105VKU nucleicacid-binding protein HEC60_16235 ENOG4105CKD glutathione-regulated potassium-efflux system protein HEC60_16240 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HEC60_16245 ENOG4105C5H ABC transporter HEC60_16250 ENOG4105DNZ Alpha Beta Hydrolase HEC60_16260 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HEC60_16265 ENOG4108UKZ OsmC family HEC60_16270 ENOG4107RYR Transcriptional regulator, Crp Fnr family HEC60_16275 ENOG410613R integral membrane protein, YccS YhfK family HEC60_16280 ENOG4105C8Y Acetylornithine aminotransferase HEC60_16285 ENOG4105DDQ anthranilate synthase HEC60_16290 ENOG4105MZU cell filamentation protein HEC60_16300 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HEC60_16305 ENOG4106DTQ Protein TsgA homolog HEC60_16310 ENOG4105DZC cytosine deaminase HEC60_16315 ENOG4107QZF nitrite reductase NADPH large subunit HEC60_16320 ENOG4105WZK nitrite reductase NADPH small subunit HEC60_16330 ENOG4105C31 Tryptophanyl-tRNA synthetase HEC60_16340 ENOG4105DJV ribulose-phosphate 3-epimerase HEC60_16345 ENOG4105DFE Dna adenine methylase HEC60_16350 ENOG4105EGB membrane protein DamX HEC60_16360 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HEC60_16365 ENOG4105E4G Type IV pilus HEC60_16385 ENOG4108U1Q Pilus assembly protein HEC60_16390 ENOG4108JQC penicillin-binding protein 1A HEC60_16395 ENOG4107RK2 ADP-ribose diphosphatase NudE HEC60_16405 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HEC60_16410 ENOG4105VEJ Heat shock protein HEC60_16425 ENOG4105E0F Histidine kinase HEC60_16435 ENOG4108RRZ Transcription elongation factor GreB HEC60_16440 ENOG4105BZM domain protein HEC60_16445 ENOG4105XFK Ferrous iron transport protein A HEC60_16450 ENOG4105CE1 Ferrous iron transport protein b HEC60_16455 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HEC60_16470 ENOG4105MJ2 Competence protein HEC60_16475 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HEC60_16480 ENOG4105C6Z Gluconate HEC60_16485 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HEC60_16490 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEC60_16500 ENOG4105E98 transcriptional regulator DeoR family HEC60_16505 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HEC60_16510 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HEC60_16515 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HEC60_16520 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HEC60_16525 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HEC60_16535 ENOG4108IUM Glycogen debranching enzyme HEC60_16540 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HEC60_16545 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HEC60_16550 ENOG4105C6Z Gluconate HEC60_16555 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HEC60_16560 ENOG4105DIQ Transcriptional regulator HEC60_16565 ENOG4105C2I pirin domain protein HEC60_16570 ENOG4105D9R oxidoreductase HEC60_16575 ENOG4105WCN acetyltransferase HEC60_16580 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HEC60_16585 ENOG4105WC8 Conserved Protein HEC60_16590 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HEC60_16605 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HEC60_16610 ENOG4105BZ7 extracellular solute-binding protein family 1 HEC60_16615 ENOG4108IV0 ABC, transporter HEC60_16620 ENOG4105C0Z ABC transporter HEC60_16625 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HEC60_16630 ENOG4105C32 Amino acid ABC transporter (Permease) HEC60_16635 ENOG4105CP9 extracellular ligand-binding receptor HEC60_16640 ENOG4105U59 -acetyltransferase HEC60_16645 ENOG4105CP9 extracellular ligand-binding receptor HEC60_16650 ENOG4108JPW Aminotransferase HEC60_16660 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HEC60_16665 ENOG4105CRP Part of the ABC transporter FtsEX involved in HEC60_16670 ENOG4105CAK Cell division ATP-binding protein ftsE HEC60_16675 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HEC60_16680 ENOG4106H78 methyltransferase HEC60_16685 ENOG4105MG3 Membrane HEC60_16695 ENOG4107FS9 Membrane HEC60_16705 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HEC60_16710 ENOG4105EX9 Membrane HEC60_16715 ENOG4108W1V Lipoprotein HEC60_16720 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HEC60_16730 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HEC60_16775 ENOG4105CBX hi0933 family HEC60_16780 ENOG4105CJ3 phosphate transporter HEC60_16785 ENOG4108V6B universal stress protein B HEC60_16795 ENOG4105DUX Transporter HEC60_16805 ENOG4105DGW oligopeptidase A HEC60_16810 ENOG4105D6S protein involved in catabolism of external DNA HEC60_16815 ENOG4105DC8 reductase HEC60_16825 ENOG4107QN2 dihydrolipoyl dehydrogenase HEC60_16830 ENOG4108K01 transcriptional regulator HEC60_16835 ENOG4108IJF Heavy metal efflux pump, CzcA HEC60_16840 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HEC60_16845 ENOG410624V efflux system protein HEC60_16850 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HEC60_16855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC60_16860 ENOG4105GR3 Histidine kinase HEC60_16885 ENOG4105CHR reductase HEC60_16890 ENOG4105CBN LysR family transcriptional regulator HEC60_16895 ENOG4107H3J ribonuclease HEC60_16900 ENOG4105CSH Transporter HEC60_16905 ENOG41066T0 asmA family HEC60_16910 ENOG4105CMB EAL domain-containing protein HEC60_16920 ENOG4105CS0 peptidase HEC60_16925 ENOG4105CK2 sodium dicarboxylate symporter HEC60_16930 ENOG4105BZU Histidine kinase HEC60_16935 ENOG4105EJG cellulose synthase HEC60_16940 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HEC60_16945 ENOG4107EEX Cellulose synthase regulator protein HEC60_16950 ENOG4107QZ7 Cellulose synthase catalytic subunit HEC60_16955 ENOG4105UTS cellulose synthase operon protein YhjQ HEC60_16960 ENOG410661M cytoplasmic protein HEC60_16970 ENOG4105WQA Cellulose biosynthesis protein BcsF HEC60_16975 ENOG4105D1V cellulose synthase operon protein YhjU HEC60_16980 ENOG4105C28 cystathionine HEC60_16985 ENOG4105C44 Serine transporter HEC60_16990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC60_17005 ENOG4108JQ7 (ABC) transporter HEC60_17010 ENOG4105C3U ABC transporter HEC60_17015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HEC60_17020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HEC60_17025 ENOG4105DEF Extracellular solute-binding protein, family 5 HEC60_17050 ENOG4105DIJ Phosphoethanolamine transferase HEC60_17055 ENOG4105FCD Major Facilitator HEC60_17060 ENOG4105EAX Putative lipase HEC60_17065 ENOG4108R3E Dna-3-methyladenine glycosylase i HEC60_17070 ENOG4105HNP -acetyltransferase HEC60_17075 ENOG4107QY8 reductase HEC60_17080 ENOG4108ZG0 Ompa motb domain protein HEC60_17085 ENOG4105C5I Dehydrogenase HEC60_17090 ENOG4106JH6 (LipO)protein HEC60_17095 ENOG4105MVF Transcriptional regulator HEC60_17105 ENOG4105C5H ABC transporter HEC60_17110 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HEC60_17125 ENOG4105MEV Acyl-transferase HEC60_17130 ENOG4105CMG Carbohydrate kinase HEC60_17135 ENOG4105C93 Xylose Isomerase HEC60_17140 ENOG4105DFW ABC transporter HEC60_17145 ENOG4105C2J ABC transporter HEC60_17150 ENOG4108HWW ABC transporter HEC60_17155 ENOG4105T16 Transcriptional regulator (AraC family) HEC60_17160 ENOG4108UR8 BAX protein HEC60_17165 ENOG4107T9C Alpha amylase catalytic region HEC60_17170 ENOG4105JKW Valine--pyruvate aminotransferase HEC60_17200 ENOG4105CT4 transporter HEC60_17210 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HEC60_17220 ENOG4105C26 Dehydrogenase HEC60_17225 ENOG4105C0A alcohol dehydrogenase HEC60_17230 ENOG4105EM7 Selenocysteine-specific translation elongation factor HEC60_17240 ENOG4108U78 Glutathione S-transferase HEC60_17245 ENOG4105EFX secretion protein, HlyD family HEC60_17250 ENOG4105FP6 Protein of unknown function (DUF3302) HEC60_17255 ENOG4105CTS PTS system mannitol-specific HEC60_17265 ENOG4105E61 Mannitol repressor protein HEC60_17270 ENOG4108YYI Protein of unknown function (DUF2810) HEC60_17275 ENOG4105DAA L-lactate HEC60_17280 ENOG41073TP transcriptional regulator HEC60_17285 ENOG4105DMF Dehydrogenase HEC60_17290 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HEC60_17295 ENOG4105D7W serine acetyltransferase HEC60_17305 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HEC60_17310 ENOG4105VW4 glutaredoxin 3 HEC60_17315 ENOG4107YZP Rhodanese domain protein HEC60_17320 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HEC60_17325 ENOG41063SB peptidase HEC60_17330 ENOG4105PXI polysaccharide deacetylase HEC60_17335 ENOG4106WTF Glycosyl transferase, family 2 HEC60_17340 ENOG4105CPQ Dehydrogenase HEC60_17345 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HEC60_17355 ENOG4105XA0 heptosyltransferase ii HEC60_17360 ENOG4105D16 lipopolysaccharide heptosyltransferase i HEC60_17365 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HEC60_17370 ENOG41068PG O-Antigen polymerase HEC60_17375 ENOG4107XU6 Glycosyl transferase (Group 1 HEC60_17385 ENOG4105DKP glycosyl transferase, family 9 HEC60_17390 ENOG4105CPK Glycosyl transferase (Group 1 HEC60_17395 ENOG4105CPK Glycosyl transferase (Group 1 HEC60_17400 ENOG4105K64 Glycosyl transferase, family 2 HEC60_17410 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HEC60_17415 ENOG4106WTF Glycosyl transferase, family 2 HEC60_17420 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HEC60_17425 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HEC60_17430 ENOG4105W0E 50S ribosomal protein L33 HEC60_17435 ENOG4105KDC 50s ribosomal protein l28 HEC60_17445 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HEC60_17450 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HEC60_17455 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HEC60_17465 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HEC60_17470 ENOG4105DSJ YicC domain protein HEC60_17475 ENOG4105EN6 Membrane HEC60_17485 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HEC60_17495 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HEC60_17500 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HEC60_17505 ENOG4105CB5 ATP-dependent DNA helicase recG HEC60_17510 ENOG4105CBT Fructose-1,6-bisphosphatase HEC60_17515 ENOG4105DP0 ferredoxin-NADP reductase HEC60_17520 ENOG4108VTS Membrane HEC60_17525 ENOG4105EBK exported protein HEC60_17530 ENOG4105CP7 Triose-phosphate isomerase HEC60_17550 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HEC60_17555 ENOG4108Y73 Membrane HEC60_17560 ENOG4105EJ2 Transcriptional regulator HEC60_17570 ENOG4105C5Q Transcriptional regulator HEC60_17580 ENOG4105CAS nag kinase HEC60_17585 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HEC60_17605 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HEC60_17610 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HEC60_17615 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) HEC60_17620 ENOG4108UZ3 Transporter HEC60_17630 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HEC60_17650 ENOG4106S9K Transcriptional regulator HEC60_17655 ENOG4107STF Involved in phosphonate degradation (By similarity) HEC60_17660 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HEC60_17670 ENOG4108SAJ Protein of unknown function (DUF1198) HEC60_17675 ENOG4105CXY transporter HEC60_17680 ENOG4105CXY transporter HEC60_17685 ENOG4105BZU Histidine kinase HEC60_17690 ENOG4108KX4 response regulator HEC60_17695 ENOG4105M71 acetolactate synthase 1 regulatory subunit HEC60_17700 ENOG4105C7K acetolactate synthase HEC60_17715 ENOG4105E5M Multidrug resistance protein D HEC60_17720 ENOG4105C4X radical SAM domain protein HEC60_17725 ENOG4105JP4 Inner membrane protein yidG HEC60_17730 ENOG4105VG5 Membrane HEC60_17750 ENOG4105R2A (LipO)protein HEC60_17755 ENOG4105D99 atp gtp-binding protein HEC60_17760 ENOG4105DJB Major Facilitator Superfamily HEC60_17765 ENOG4105CXK mandelate racemase muconate lactonizing HEC60_17770 ENOG4108RTU Aldolase HEC60_17775 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HEC60_17780 ENOG4105EMF GntR family transcriptional regulator HEC60_17800 ENOG410667J hydrolase HEC60_17805 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HEC60_17810 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HEC60_17815 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HEC60_17825 ENOG4105VG0 50S ribosomal protein l34 HEC60_17830 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HEC60_17840 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HEC60_17845 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HEC60_17850 ENOG4105CC5 ABC transporter HEC60_17855 ENOG4105CC5 ABC transporter HEC60_17860 ENOG4105DIK (ABC) transporter HEC60_17870 ENOG4105CNH Multidrug resistance protein MdtL HEC60_17875 ENOG4105G2Y Transcriptional regulator HEC60_17880 ENOG4105E8Q phosphopantetheinyl transferase HEC60_17885 ENOG4108YYH Nadph-dependent fmn reductase HEC60_17890 ENOG4105C7N Xanthine uracil vitamin C permease HEC60_17895 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HEC60_17905 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HEC60_17910 ENOG4105E2Z phosphate ABC transporter (Permease HEC60_17915 ENOG4105C8U phosphate abc transporter HEC60_17920 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HEC60_17935 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HEC60_17940 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HEC60_17945 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HEC60_17950 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HEC60_17960 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HEC60_17970 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HEC60_17980 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HEC60_17985 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HEC60_17990 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HEC60_17995 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HEC60_18000 ENOG4105QTB Flavodoxin HEC60_18005 ENOG4108VVK transcriptional Regulator, AsnC HEC60_18035 ENOG4105C2J ABC transporter HEC60_18040 ENOG4105CNN ABC, transporter HEC60_18045 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HEC60_18050 ENOG4108RVA ribokinase HEC60_18055 ENOG4105ETE Transcriptional regulator (LacI family HEC60_18060 ENOG4105C0R drug resistance transporter emrb qaca subfamily HEC60_18065 ENOG4107EJG GntR family transcriptional regulator HEC60_18090 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HEC60_18095 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HEC60_18100 ENOG4105PC1 Conserved Protein HEC60_18105 ENOG4105E27 serine threonine protein kinase HEC60_18110 ENOG4108Z33 Thiol disulfide Interchange Protein HEC60_18115 ENOG4106HNH Acyl-transferase HEC60_18120 ENOG4105C2M dna polymerase I HEC60_18130 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HEC60_18135 ENOG4105D4P Coproporphyrinogen iii oxidase HEC60_18140 ENOG4106FIY HEC60_18145 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HEC60_18150 ENOG4105CUX Signal transduction histidine kinase HEC60_18155 ENOG4105C5F glutamine synthetase HEC60_18160 ENOG4105CI3 gtp-binding protein typa HEC60_18165 ENOG4108K85 Transcriptional regulator HEC60_18170 ENOG4108KHF Resistance protein HEC60_18175 ENOG4105R9B Major Facilitator HEC60_18185 ENOG4105ISV protein with bipartite regulator domain HEC60_18200 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HEC60_18210 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HEC60_18215 ENOG4105SUU thioesterase domain HEC60_18220 ENOG41068KX affects formate dehydrogenase-N HEC60_18235 ENOG4108MG3 formate dehydrogenase HEC60_18240 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HEC60_18250 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HEC60_18265 ENOG4108UMN azlc family HEC60_18275 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HEC60_18280 ENOG4105C0A alcohol dehydrogenase HEC60_18300 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HEC60_18305 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HEC60_18315 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HEC60_18325 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HEC60_18330 ENOG4108RPX mosc domain containing protein HEC60_18335 ENOG4105E0F Histidine kinase HEC60_18340 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC60_18345 ENOG4105FMW periplasmic HEC60_18350 ENOG41076HS cation diffusion facilitator family transporter HEC60_18355 ENOG4105CTQ phosphohexokinase HEC60_18360 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HEC60_18365 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HEC60_18370 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HEC60_18375 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HEC60_18380 ENOG41063M6 Cell Division Protein HEC60_18385 ENOG4105ETE Transcriptional regulator (LacI family HEC60_18390 ENOG4105C25 Primosomal protein n' HEC60_18395 ENOG4105VFB Binds the 23S rRNA (By similarity) HEC60_18400 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HEC60_18405 ENOG4105C28 cystathionine HEC60_18410 ENOG4105CFH Aspartokinase HEC60_18415 ENOG4105SYT Methylenetetrahydrofolate reductase HEC60_18420 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HEC60_18425 ENOG4108Q5Y Membrane HEC60_18430 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HEC60_18440 ENOG4108RPX mosc domain containing protein HEC60_18450 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HEC60_18455 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HEC60_18460 ENOG4105E0A ABC, transporter HEC60_18465 ENOG4105EHG Permease protein HEC60_18470 ENOG4105S10 periplasmic binding protein HEC60_18485 ENOG4105CT4 transporter HEC60_18490 ENOG4105CJQ hydrolase, family 31 HEC60_18500 ENOG4105F8D glycoside hydrolase family 4 HEC60_18505 ENOG4105CI1 PTS System HEC60_18510 ENOG4105JV1 AsmA family HEC60_18515 ENOG4105C2W permease HEC60_18520 ENOG4105D6U Sodium Glutamate Symporter HEC60_18525 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HEC60_18530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HEC60_18535 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HEC60_18595 ENOG4108WFC UPF0438 protein yifE HEC60_18600 ENOG4105C0P Mg chelatase subunit ChlI HEC60_18615 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HEC60_18620 ENOG4105CM2 brancheD-chain amino acid aminotransferase HEC60_18630 ENOG4105C7B Threonine dehydratase HEC60_18635 ENOG4105EMY transcriptional regulator HEC60_18640 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HEC60_18645 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HEC60_18650 ENOG4105C4R Atp-dependent dna helicase HEC60_18655 ENOG4105C9X ppx gppa phosphatase HEC60_18660 ENOG4105C1J atp-dependent rna helicase HEC60_18675 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HEC60_18680 ENOG4105ESV Glycosyl transferase, family 4 HEC60_18685 ENOG4105SFE lipopolysaccharide biosynthesis protein HEC60_18690 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HEC60_18695 ENOG4107QQG Dehydrogenase HEC60_18700 ENOG4108WJ1 acetyltransferase HEC60_18705 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HEC60_18710 ENOG4105EGZ biosynthesis protein HEC60_18715 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HEC60_18720 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HEC60_18725 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HEC60_18730 ENOG4105C85 amino acid HEC60_18755 ENOG410601J HemY protein HEC60_18760 ENOG4105ECF c-methyltransferase HEC60_18765 ENOG41076E6 Uroporphyrinogen-III Synthase HEC60_18770 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HEC60_18775 ENOG4107T0K Adenylate cyclase HEC60_18785 ENOG4105S7Z (LipO)protein HEC60_18795 ENOG4105CT0 Protein of unknown function, DUF484 HEC60_18800 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HEC60_18805 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HEC60_18810 ENOG4105C4R Atp-dependent dna helicase HEC60_18815 ENOG4107QUT magnesium and cobalt transport protein CorA HEC60_18820 ENOG4105FR1 rard protein HEC60_18825 ENOG4108VUY thioesterase Superfamily protein HEC60_18830 ENOG4105HDD phospholipase HEC60_18835 ENOG4105C9U ATP-dependent DNA helicase RecQ HEC60_18840 ENOG4105CCF Lysine exporter protein (Lyse ygga) HEC60_18845 ENOG410829K Lysine exporter protein (Lyse ygga) HEC60_18850 ENOG4108EUD Lysophospholipase HEC60_18855 ENOG4105DQF Hydrolase HEC60_18860 ENOG4105EMK carboxylate amino acid amine transporter HEC60_18865 ENOG4105DZ2 Transcriptional regulator HEC60_18885 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HEC60_18890 ENOG4107SXA Phosphorylase HEC60_18895 ENOG4105CGY Dna recombination protein HEC60_18905 ENOG4105JC1 sterol-binding domain protein HEC60_18910 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HEC60_18915 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HEC60_18920 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HEC60_18925 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HEC60_18930 ENOG4105F8V Hydrolase, tatD family HEC60_18935 ENOG4105MDZ Transcriptional activator rfaH HEC60_18945 ENOG4107QK7 reductase HEC60_18950 ENOG4105CHU acetyl-coa acetyltransferase HEC60_18955 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HEC60_18960 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HEC60_18965 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HEC60_18970 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HEC60_18975 ENOG4108RR8 protoporphyrinogen oxidase HEC60_19000 ENOG4105D4A Cell wall formation (By similarity) HEC60_19005 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HEC60_19010 ENOG4105CS9 pantothenic acid kinase HEC60_19040 ENOG4105PM1 preprotein translocase subunit SecE HEC60_19045 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HEC60_19060 ENOG4108VZM 50s ribosomal protein L10 HEC60_19070 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC60_19075 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HEC60_19090 ENOG4106TD9 Diguanylate cyclase HEC60_19095 ENOG4105D41 biosynthesis protein thiH HEC60_19100 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HEC60_19105 ENOG4105WHD thiamine biosynthesis protein ThiS HEC60_19110 ENOG4105D06 uba thif-type nad fad binding protein HEC60_19120 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HEC60_19125 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HEC60_19135 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HEC60_19145 ENOG4105R2J Conserved Protein HEC60_19155 ENOG4108T8B Protein of unknown function (DUF1481) HEC60_19160 ENOG4105C12 Phosphoribosylglycinamide synthetase HEC60_19165 ENOG4105DC1 bifunctional purine biosynthesis protein purh HEC60_19195 ENOG4105K5X acetyltransferase HEC60_19205 ENOG4107QP3 malate synthase g HEC60_19210 ENOG4108I9X Isocitrate lyase HEC60_19215 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HEC60_19220 ENOG41069M3 Transcriptional regulator HEC60_19225 ENOG4105C3R Methionine synthase HEC60_19230 ENOG4105EAM Na Pi-cotransporter HEC60_19235 ENOG4105YES addiction module antidote protein HEC60_19245 ENOG4105FE9 pseudouridine synthase HEC60_19250 ENOG4108ZR5 Conserved Protein HEC60_19255 ENOG4105CFH Aspartokinase HEC60_19270 ENOG4108MDC (LipO)protein HEC60_19275 ENOG4108Q9C Periplasmic Protein HEC60_19280 ENOG4105E3R (LipO)protein HEC60_19290 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HEC60_19295 ENOG4105EG2 ABC transporter, permease HEC60_19300 ENOG4105D56 permease protein HEC60_19305 ENOG4107FKK extracellular solute-binding protein family 1 HEC60_19310 ENOG4108IJ9 (ABC) transporter HEC60_19320 ENOG4107W52 maltose operon periplasmic protein HEC60_19325 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HEC60_19340 ENOG41080IJ Diacylglycerol kinase HEC60_19350 ENOG4107R73 Mate efflux family protein HEC60_19355 ENOG4105MYN Zinc uptake regulation protein HEC60_19370 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HEC60_19375 ENOG4105P4Z Phage shock protein G HEC60_19380 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HEC60_19385 ENOG4105CDU Replicative dna helicase HEC60_19390 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HEC60_19395 ENOG4105CGF Aromatic amino acid aminotransferase HEC60_19400 ENOG4105F0S class B acid phosphatase HEC60_19405 ENOG4105MSB protein, conserved in bacteria HEC60_19420 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HEC60_19425 ENOG4108UUM single-stranded DNA-binding protein HEC60_19435 ENOG4105PMV Membrane HEC60_19440 ENOG4108M8H domain protein HEC60_19445 ENOG4108W3Q Transcriptional regulator HEC60_19450 ENOG4108Z4X TRANSCRIPTIONal HEC60_19455 ENOG4108RXX maleylacetoacetate isomerase HEC60_19460 ENOG4105C7N Xanthine uracil vitamin C permease HEC60_19465 ENOG4105EEQ Na H antiporter HEC60_19470 ENOG4105CMU LysR family (Transcriptional regulator HEC60_19480 ENOG41067MG lrgb family HEC60_19485 ENOG4107QN1 sodium solute HEC60_19490 ENOG41062QD Membrane HEC60_19495 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HEC60_19500 ENOG4105CK2 sodium dicarboxylate symporter HEC60_19505 ENOG41082ND Uncharacterized protein yjcO HEC60_19510 ENOG41074AV Hok/gef family HEC60_19520 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 HEC60_19525 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HEC60_19530 ENOG410849A acetyltransferase, (GNAT) family HEC60_19535 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HEC60_19540 ENOG4105FD8 phosphonate metabolism protein PhnM HEC60_19545 ENOG4105HRV phosphonate c-p lyase system protein phnl HEC60_19550 ENOG4105ENV phosphonate C-P lyase system protein PhnK HEC60_19555 ENOG4105FT8 Phosphonate metabolism HEC60_19560 ENOG4105EKV Phosphonate metabolism protein HEC60_19565 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HEC60_19570 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HEC60_19575 ENOG4107RJJ Transcriptional regulator HEC60_19585 ENOG4105EHI Phosphonate ABC transporter, periplasmic HEC60_19590 ENOG4105D5T phosphonate abc transporter HEC60_19595 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HEC60_19600 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HEC60_19605 ENOG4108F5E vimentin HEC60_19610 ENOG4108YIV HEC60_19615 ENOG4105CSH Transporter HEC60_19620 ENOG4105BZU Histidine kinase HEC60_19630 ENOG4105ETT transcriptional Regulator, LysR family HEC60_19635 ENOG4105R1U AraC Family Transcriptional Regulator HEC60_19640 ENOG4105D7X high-affinity nickel-transporter HEC60_19675 ENOG4108SIC Transcriptional regulator HEC60_19680 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HEC60_19690 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HEC60_19695 ENOG4108IJ0 Aspartate ammonia-lyase HEC60_19700 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HEC60_19710 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HEC60_19715 ENOG4108ZVF (LipO)protein HEC60_19720 ENOG4105MTB Uncharacterized protein YjeJ HEC60_19725 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HEC60_19745 ENOG4105KPY Small multidrug resistance protein HEC60_19765 ENOG4105E33 succinate dehydrogenase HEC60_19770 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HEC60_19775 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HEC60_19780 ENOG4105EGS Mechanosensitive ion channel HEC60_19785 ENOG4105DJ4 phosphatidylserine decarboxylase HEC60_19795 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HEC60_19815 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HEC60_19820 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HEC60_19825 ENOG4105K8N protein family UPF0079, ATPase HEC60_19830 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HEC60_19840 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HEC60_19845 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HEC60_19850 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HEC60_19855 ENOG4107QJR hflk protein HEC60_19860 ENOG4105EPW hflc protein HEC60_19870 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HEC60_19880 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HEC60_19885 ENOG4105C2N RNA methyltransferase TrmH family group 3 HEC60_19890 ENOG4105CSH Transporter HEC60_19895 ENOG4105CSU acyl-Coa dehydrogenase HEC60_19900 ENOG4105S17 UPF0379 protein yjfN HEC60_19905 ENOG4105WSB biofilm stress and motility protein A HEC60_19910 ENOG4108MXZ Esterase HEC60_19955 ENOG4105KIT UPF0379 protein yjfY HEC60_19960 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HEC60_19965 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HEC60_19970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HEC60_19975 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HEC60_19985 ENOG4105FHY Opacity-associated protein A HEC60_19990 ENOG4108V1T peptidylprolyl cis-trans isomerase HEC60_19995 ENOG4105C85 amino acid HEC60_20005 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_20010 ENOG4105DXC membrane HEC60_20020 ENOG4105ECR NmrA family HEC60_20025 ENOG4105KVH Transcriptional regulator HEC60_20030 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HEC60_20035 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HEC60_20040 ENOG4108UUE Transcriptional regulator HEC60_20045 ENOG41061GZ Protein of unknown function (DUF1107) HEC60_20050 ENOG4105C37 (CBS) domain HEC60_20060 ENOG4105CFU surface antigen HEC60_20065 ENOG4105MA0 exported protein HEC60_20070 ENOG4108ZHD aig2 family HEC60_20080 ENOG4105F0N pyrophosphate phospho-hydrolase HEC60_20085 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HEC60_20090 ENOG4105C2J ABC transporter HEC60_20095 ENOG4107R9N ABC transporter HEC60_20100 ENOG41062B0 ABC transporter, permease HEC60_20105 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_20110 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HEC60_20115 ENOG4105DFU Cell wall formation (By similarity) HEC60_20120 ENOG4105N42 UPF0307 protein HEC60_20125 ENOG4105CMS peptidase U62, modulator of DNA gyrase HEC60_20160 ENOG41069H0 dihydroorotase EC 3.5.2.3 HEC60_20180 ENOG4105EMD TRANSCRIPTIONal HEC60_20190 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HEC60_20200 ENOG4105EXG Transcriptional regulator HEC60_20205 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HEC60_20220 ENOG4105F8D glycoside hydrolase family 4 HEC60_20225 ENOG4105CK1 PTS System HEC60_20230 ENOG4105CG3 alpha amylase, catalytic region HEC60_20235 ENOG4105C5Y PTS System HEC60_20240 ENOG4105D4X repressor HEC60_20250 ENOG4105E2D ec 3.2.1.52 HEC60_20255 ENOG4105KME endoribonuclease L-psp HEC60_20265 ENOG4105CXT aspartate transcarbamylase HEC60_20270 ENOG4107C93 pyrBI operon leader peptide HEC60_20275 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HEC60_20285 ENOG4105DBV ornithine carbamoyltransferase HEC60_20295 ENOG4105CEU Arginine dihydrolase HEC60_20300 ENOG4105XEP YhcH YjgK YiaL family protein HEC60_20310 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HEC60_20315 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HEC60_20320 ENOG4108MJ3 acetyltransferase HEC60_20330 ENOG4105MYG DNA polymerase iii, chi subunit HEC60_20335 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HEC60_20340 ENOG4108M8S permease YjgP YjgQ family protein HEC60_20345 ENOG4108K5H permease YjgP YjgQ family protein HEC60_20350 ENOG4105D7A ATP-binding protein HEC60_20360 ENOG4105DQ4 alcohol dehydrogenase HEC60_20395 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HEC60_20405 ENOG4107XZC Restriction modification system DNA (Specificity HEC60_20410 ENOG4105CVR type I restriction-modification system HEC60_20445 ENOG4105Y50 Virulence Protein HEC60_20485 ENOG4108MXD gtp-binding protein HEC60_20505 ENOG4106H6R UPF0380 protein HEC60_20510 ENOG4106549 Antirestriction protein HEC60_20515 ENOG4108XS9 dna repair protein HEC60_20520 ENOG4105ZS6 Protein of unknown function (DUF987) HEC60_20525 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HEC60_20540 ENOG4105HVQ Regulatory factor of maltose metabolism HEC60_20565 ENOG4108Z6B deaminase HEC60_20570 ENOG4105E5D amino acid HEC60_20585 ENOG4105C26 Dehydrogenase HEC60_20600 ENOG4105EZE Cupin 4 family protein HEC60_20610 ENOG4105C2W permease HEC60_20615 ENOG4105BZ8 glutamate synthase HEC60_20620 ENOG4108R8B oxidoreductase Fe-S subunit HEC60_20625 ENOG4105C7N Xanthine uracil vitamin C permease HEC60_20630 ENOG4107QUY Guanine deaminase HEC60_20635 ENOG4105C2W permease HEC60_20640 ENOG4105C7W Xanthine dehydrogenase HEC60_20645 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HEC60_20650 ENOG4107UUR Chlorohydrolase aminohydrolase HEC60_20655 ENOG4105BZ8 glutamate synthase HEC60_20660 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HEC60_20665 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HEC60_20670 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HEC60_20675 ENOG4105C5B carbamate kinase HEC60_20685 ENOG4107S4Y M20 DapE family protein YgeY HEC60_20690 ENOG4107RCH Diaminopropionate ammonia-lyase HEC60_20695 ENOG4105IW6 Carbamoyltransferase HEC60_20700 ENOG4108JUB Transcriptional regulator HEC60_20705 ENOG4108UTP (2Fe-2S)-binding domain protein HEC60_20710 ENOG4108HR6 Dehydrogenase HEC60_20715 ENOG4105C7W Xanthine dehydrogenase HEC60_20730 ENOG4105F3R pts system mannose fructose sorbose family iid HEC60_20735 ENOG4105ETZ PTS System HEC60_20740 ENOG4105DAS pts system HEC60_20755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HEC60_20760 ENOG4106DIZ Domain of unknown function (DUF1127) HEC60_20770 ENOG4105J12 Multidrug resistance protein mdtN HEC60_20780 ENOG4107UWN reductase HEC60_20785 ENOG4105EFA 4-hydroxyphenylacetate HEC60_20790 ENOG4108NKV transcriptional regulator HEC60_20800 ENOG4105CNV Aldolase HEC60_20815 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HEC60_20820 ENOG4105C26 Dehydrogenase HEC60_20825 ENOG4105ERH Fumarylacetoacetate hydrolase HEC60_20830 ENOG4108V8F Transcriptional regulator, MarR family HEC60_20840 ENOG4105CIZ coA-substrate-specific enzyme activase HEC60_20845 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HEC60_20855 ENOG4105W8I Transcriptional regulator HEC60_20860 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HEC60_20865 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HEC60_20880 ENOG4107WFU Glutamate mutase subunit sigma HEC60_20890 ENOG4105DJI Methylaspartate mutase, E subunit HEC60_20910 ENOG4105CK2 sodium dicarboxylate symporter HEC60_20915 ENOG4105CSV Glutaminase HEC60_20920 ENOG4107GFK fumarate HEC60_20925 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HEC60_20930 ENOG41083G8 Multidrug resistance protein MdtM HEC60_20935 ENOG4106BRA Membrane HEC60_20945 ENOG4105CKI cobalamin synthesis protein HEC60_20950 ENOG4105VCD cytoplasmic protein HEC60_20955 ENOG4105D22 carbon starvation protein HEC60_20980 ENOG4105C8Q Methyl-accepting chemotaxis HEC60_20995 ENOG4107RES phosphoglycerol transferase I HEC60_21000 ENOG4105RI1 glycoprotein receptor HEC60_21005 ENOG4106CVF DNA replication protein HEC60_21015 ENOG4108ZHJ Organic hydroperoxide resistance protein HEC60_21020 ENOG4107XM3 UPF0442 protein HEC60_21025 ENOG4105DWK Membrane HEC60_21035 ENOG4108T94 DNA-binding transcriptional activator BglJ HEC60_21040 ENOG4108UIN ybak prolyl-trna synthetase associated region HEC60_21045 ENOG4105CK1 PTS System HEC60_21050 ENOG4108819 ferric iron reductase HEC60_21055 ENOG4106TD9 Diguanylate cyclase HEC60_21060 ENOG4105YBH Protein of unknown function (DUF1435) HEC60_21085 ENOG4108WPU DNA polymerase III subunit psi HEC60_21090 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HEC60_21095 ENOG4105PAD Hydrolase HEC60_21100 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HEC60_21105 ENOG4105K3G Periplasmic Protein HEC60_21115 ENOG4108NRW Phospholipase, patatin family HEC60_21120 ENOG4105EYA deoxyribonuclease HEC60_21125 ENOG41076CZ activating enzyme HEC60_21130 ENOG4105G0K glycine radical enzyme YjjI family HEC60_21150 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HEC60_21160 ENOG41062Z9 Membrane HEC60_21165 ENOG4105EAC phosphoserine phosphatase HEC60_21170 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HEC60_21175 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HEC60_21180 ENOG4105C5H ABC transporter HEC60_21185 ENOG4107SC1 transglycosylase HEC60_21195 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HEC60_21200 ENOG4105CVJ phosphoglycerate mutase HEC60_21205 ENOG4105UEI Transcriptional Regulator AraC Family HEC60_21210 ENOG4108RH0 Crea protein HEC60_21215 ENOG4105E3W Two component transcriptional regulator (Winged helix family HEC60_21220 ENOG4105EB3 Histidine kinase HEC60_21225 ENOG4105CT7 inner membrane cred family protein HEC60_21230 ENOG41065U4 response regulator HEC60_21235 ENOG410759A HEC60_21240 ENOG4106FVC RNA methyltransferase HEC60_21250 ENOG4105CFH Aspartokinase HEC60_21260 ENOG4105D98 threonine synthase HEC60_21265 ENOG41062C6 Protein of unknown function (DUF2502) HEC60_21270 ENOG4105D1Q UPF0246 protein HEC60_21275 ENOG4105BZG amino acid carrier protein HEC60_21280 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HEC60_21285 ENOG4108RIR Molybdenum cofactor biosynthesis protein HEC60_21295 ENOG4106HK8 GPR1 FUN34 yaaH family protein HEC60_21300 ENOG4105CFG Acts as a chaperone (By similarity) HEC60_21320 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HEC60_21325 ENOG41063Z6 transcriptional regulator, lysR family HEC60_21330 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HEC60_21335 ENOG4105DTN riboflavin biosynthesis protein ribF HEC60_21350 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HEC60_21360 ENOG4105DU0 nucleoside hydrolase HEC60_21365 ENOG4108Y83 glucose-6-phosphate isomerase HEC60_21375 ENOG4105F3R pts system mannose fructose sorbose family iid HEC60_21380 ENOG4105ETZ PTS System HEC60_21385 ENOG4105DAS pts system HEC60_21400 ENOG4107P2S Transcriptional regulator HEC60_21410 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HEC60_21415 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HEC60_21420 ENOG4105M5B (LipO)protein HEC60_21425 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HEC60_21435 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HEC60_21445 ENOG4105NWN ApaG protein HEC60_21450 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HEC60_21455 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HEC60_21465 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HEC60_21470 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HEC60_21475 ENOG4105D3G Pseudouridine synthase HEC60_21480 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HEC60_21485 ENOG4105CQ2 DNA polymerase HEC60_21490 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HEC60_21495 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HEC60_21500 ENOG4105EF1 ribulokinase HEC60_21510 ENOG4107RRE RNA-directed DNA polymerase HEC60_21515 ENOG4108KF1 Membrane HEC60_21525 ENOG4106SMU thiamine transporter membrane protein HEC60_21540 ENOG4105S8Q sugar efflux transporter HEC60_21545 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HEC60_21570 ENOG41064T2 transcriptional regulator, lysR family HEC60_21575 ENOG4105C7K acetolactate synthase HEC60_21580 ENOG4108ZP8 Acetolactate synthase small subunit HEC60_21585 ENOG4107B7Y DNA-binding transcriptional regulator FruR HEC60_21600 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HEC60_21605 ENOG4105CJN penicillin-binding protein HEC60_21610 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HEC60_21615 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HEC60_21620 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HEC60_21625 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HEC60_21630 ENOG4105CNI cell division protein FtsW HEC60_21635 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HEC60_21640 ENOG4105DFU Cell wall formation (By similarity) HEC60_21650 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HEC60_21655 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HEC60_21660 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HEC60_21670 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HEC60_21675 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HEC60_21680 ENOG4105M6F mutator MutT protein HEC60_21685 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HEC60_21690 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HEC60_21695 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HEC60_21705 ENOG4105D7Q type ii secretion system HEC60_21710 ENOG4107QHF type ii secretion system protein e HEC60_21715 ENOG4108ZUW Major pilin subunit HEC60_21720 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HEC60_21730 ENOG4106A72 regulatory protein AmpE HEC60_21740 ENOG4105CT4 transporter HEC60_21745 ENOG4105C85 amino acid HEC60_21750 ENOG41073TP transcriptional regulator HEC60_21755 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HEC60_21760 ENOG4107QSN dihydrolipoamide acetyltransferase HEC60_21765 ENOG4107QN2 dihydrolipoyl dehydrogenase HEC60_21780 ENOG4108NST exported protein HEC60_21785 ENOG4107QIJ Aconitate hydratase 2 HEC60_21795 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HEC60_21805 ENOG4108ZRK uncharacterized protein yacC HEC60_21810 ENOG4105E3B Multicopper oxidase HEC60_21815 ENOG4105DZG Dehydrogenase HEC60_21820 ENOG4108UGV hypoxanthine phosphoribosyltransferase HEC60_21825 ENOG41077A9 carbonic anhydrase HEC60_21830 ENOG4105DA5 (ABC) transporter HEC60_21835 ENOG4105E3A (ABC) transporter HEC60_21840 ENOG4108YTN IIa component HEC60_21845 ENOG4107BJW polysaccharide deacetylase HEC60_21850 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HEC60_21865 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HEC60_21870 ENOG4105DJ0 Poly(A) Polymerase HEC60_21875 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HEC60_21890 ENOG4107XID 2'-5' rna ligase HEC60_21895 ENOG4105CQ7 ATP-dependent helicase HEC60_21900 ENOG4105BZ4 penicillin-binding protein HEC60_21905 ENOG4105E0K tonB-dependent siderophore receptor HEC60_21910 ENOG4105E0A ABC, transporter HEC60_21915 ENOG4105J76 Periplasmic binding protein HEC60_21920 ENOG4105S6R Iron-hydroxamate transporter permease subunit HEC60_21925 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HEC60_21930 ENOG4105CMQ Chloride channel HEC60_21935 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HEC60_21940 ENOG4105EN6 Membrane HEC60_21955 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HEC60_21960 ENOG4105C0H protease HEC60_21965 ENOG4108T8E UPF0325 protein HEC60_21970 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HEC60_21975 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HEC60_21980 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HEC60_21985 ENOG4105CE9 30S ribosomal protein S2 HEC60_21990 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HEC60_21995 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HEC60_22000 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HEC60_22005 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HEC60_22015 ENOG4105KNE Phosphatidate cytidylyltransferase HEC60_22025 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HEC60_22030 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HEC60_22035 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HEC60_22040 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HEC60_22045 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HEC60_22050 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HEC60_22060 ENOG4105C0B DNA polymerase III (alpha subunit) HEC60_22065 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HEC60_22070 ENOG4105CXN decarboxylase HEC60_22075 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HEC60_22080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HEC60_22085 ENOG4105M1T rho-binding antiterminator HEC60_22095 ENOG4108VWS Yaeq family HEC60_22100 ENOG4108YZN class I peptide chain release factor HEC60_22105 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HEC60_22110 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HEC60_22115 ENOG4108R96 Methyltransferase, YaeB family HEC60_22120 ENOG4108R8X outer membrane lipoprotein HEC60_22125 ENOG4105D01 (LipO)protein HEC60_22130 ENOG4108UMI ABC transporter, permease HEC60_22135 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HEC60_22140 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HEC60_22175 ENOG4105CV8 reductase HEC60_22180 ENOG4105HEI LysR family (Transcriptional regulator HEC60_22185 ENOG4105F27 Major Facilitator HEC60_22190 ENOG4107NA1 Endonuclease Exonuclease phosphatase HEC60_22195 ENOG4105F2W methyltransferase HEC60_22200 ENOG4105E9H Lytic Murein transglycosylase HEC60_22205 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HEC60_22210 ENOG4105D1A Methyltransferase HEC60_22215 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HEC60_22220 ENOG4107RZZ dna polymerase iii epsilon subunit HEC60_22240 ENOG4105Y49 secretion protein, HlyD family HEC60_22255 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HEC60_22260 ENOG4107QPN acyl-Coa dehydrogenase HEC60_22265 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HEC60_22270 ENOG4105E7A Glutamine amidotransferase HEC60_22275 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HEC60_22285 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HEC60_22290 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HEC60_22295 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HEC60_22300 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HEC60_22305 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HEC60_22325 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HEC60_22330 ENOG4105CIN aminoacyl-histidine dipeptidase HEC60_22335 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HEC60_22345 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HEC60_22350 ENOG4105FCK Membrane HEC60_22355 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HEC60_22360 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HEC60_22370 ENOG4105DFP Integrase HEC60_22420 ENOG4106NDP Transcriptional regulator HEC60_22425 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HEC60_22430 ENOG4108HKT sucrose-6-phosphate hydrolase HEC60_22455 ENOG4105DWU Membrane HEC60_22485 ENOG4105E89 ABC transporter HEC60_22490 ENOG4105DTA methyltransferase HEC60_22505 ENOG4108MEK Metal-binding protein YodA HEC60_22530 ENOG4108QGT oligogalacturonate-specific porin HEC60_22540 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HEC60_22545 ENOG4105C1J atp-dependent rna helicase HEC60_22555 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HEC60_22560 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HEC60_22565 ENOG4105C2D reductase HEC60_22600 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HEC60_22630 ENOG4105E9Q Acyl-transferase HEC60_22650 ENOG4105EFX secretion protein, HlyD family HEC60_22655 ENOG4105FP6 Protein of unknown function (DUF3302) HEC60_22660 ENOG4106FTQ Taurine ABC transporter, periplasmic HEC60_22665 ENOG4108ETV ABC transporter HEC60_22670 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HEC60_22675 ENOG4105E2B Taurine dioxygenase HEC60_22685 ENOG4105D52 delta-aminolevulinic acid dehydratase HEC60_22690 ENOG4108NSE outer membrane autotransporter barrel HEC60_22695 ENOG4108PNB DNA-binding transcriptional regulator HEC60_22700 ENOG4107R6D beta-lactam binding protein AmpH HEC60_22705 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HEC60_22710 ENOG4107QS8 (LipO)protein HEC60_22715 ENOG4105FR5 inner membrane protein YaiY HEC60_22720 ENOG4105UNH Membrane HEC60_22725 ENOG4105CPF Cell wall formation (By similarity) HEC60_22735 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) HEC60_22740 ENOG4105G6Z alkaline phosphatase HEC60_22745 ENOG4105VIF phosphate starvation-inducible protein HEC60_22750 ENOG4105II7 pyrroline-5-carboxylate reductase HEC60_22760 ENOG4105G4C Periplasmic ligand-binding sensor protein HEC60_22765 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HEC60_22770 ENOG4105HBA AroM protein HEC60_22775 ENOG4105NBK UPF0345 protein HEC60_22785 ENOG4105DKQ ROK family HEC60_22790 ENOG4105EYH Exonuclease HEC60_22795 ENOG4107RH8 nuclease SbcCD subunit D HEC60_22800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HEC60_22805 ENOG4105BZU Histidine kinase HEC60_22810 ENOG4105CWM branched-chain amino acid transport system II carrier protein HEC60_22815 ENOG4105C85 amino acid HEC60_22820 ENOG4107R28 alpha amylase, catalytic region HEC60_22825 ENOG4105EQ1 Transcriptional regulator HEC60_22830 ENOG4105CHJ isochorismatase hydrolase HEC60_22840 ENOG4105EFZ amidohydrolase HEC60_22845 ENOG4105D3R alkyl hydroperoxide reductase HEC60_22850 ENOG4108ZYK Acyl carrier protein phosphodiesterase HEC60_22855 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HEC60_22860 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HEC60_22865 ENOG4105VIE preprotein translocase, subunit YajC HEC60_22870 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEC60_22875 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HEC60_22890 ENOG4105DRB nucleoside-specific channel-forming protein HEC60_22895 ENOG4108KIC (LipO)protein HEC60_22900 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HEC60_22905 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HEC60_22910 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HEC60_22915 ENOG4107YIM Involved in the transcription termination process (By similarity) HEC60_22920 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HEC60_22925 ENOG4108ZAI phosphatidylglycerophosphatase a HEC60_22930 ENOG4105CPC Aldo Keto reductase HEC60_22935 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HEC60_22940 ENOG4105CTB Polyprenyl synthetase HEC60_22945 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HEC60_22955 ENOG4107S0N DJ-1 family HEC60_22960 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HEC60_22965 ENOG4108VPT UPF0234 protein HEC60_22970 ENOG4107RDB Major Facilitator HEC60_22980 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HEC60_22985 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HEC60_22990 ENOG4105CCU oxidase (Subunit III) HEC60_22995 ENOG4105BZ9 Cytochrome C oxidase, subunit I HEC60_23000 ENOG4105E2S oxidase) subunit II HEC60_23005 ENOG4105EYM Major Facilitator superfamily HEC60_23010 ENOG4105IEY (LipO)protein HEC60_23015 ENOG4105M85 Bola protein HEC60_23020 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HEC60_23030 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HEC60_23035 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HEC60_23040 ENOG4105K70 DNA-binding protein HEC60_23045 ENOG4105EIN peptidylprolyl cis-trans isomerase HEC60_23050 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HEC60_23055 ENOG4108TGP Thioesterase superfamily protein HEC60_23065 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HEC60_23075 ENOG4108NFA extracellular solute-binding protein HEC60_23080 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HEC60_23085 ENOG4105C6T cysteine synthase HEC60_23090 ENOG4108XM1 transcriptional regulator AsnC family HEC60_23095 ENOG4105BZ1 (ABC) transporter HEC60_23100 ENOG4105BZ1 (ABC) transporter HEC60_23105 ENOG4108YZA Nitrogen regulatory protein pii HEC60_23110 ENOG4105BZU Histidine kinase HEC60_23115 ENOG4105C29 acyl-CoA thioesterase HEC60_23120 ENOG4108MNP Glycoprotein polysaccharide metabolism HEC60_23125 ENOG41080UX Methyltransferase HEC60_23140 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HEC60_23145 ENOG4107QZB decarboxylase HEC60_23150 ENOG4105JZC GHMP kinase HEC60_23155 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HEC60_23160 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HEC60_23165 ENOG41081F0 Precorrin-8x methylmutase HEC60_23170 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HEC60_23175 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HEC60_23180 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HEC60_23185 ENOG4105CIA precorrin-4 C(11)-methyltransferase HEC60_23190 ENOG4108P62 biosynthesis protein (CbiG) HEC60_23195 ENOG4105E4R Precorrin-3B C17-methyltransferase HEC60_23200 ENOG4105QUC reductase HEC60_23205 ENOG4107PPM cobalt chelatase HEC60_23210 ENOG4105DVK Precorrin-2 c20-methyltransferase HEC60_23215 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEC60_23220 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HEC60_23225 ENOG4108V4M Cobalt abc transporter HEC60_23235 ENOG41061MD high-affinity nickel-transporter HEC60_23240 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HEC60_23265 ENOG4108VW9 Membrane HEC60_23270 ENOG4105CNT hydrolase family 2 HEC60_23275 ENOG4105KCV RNA signal recognition particle 4.5S RNA HEC60_23280 ENOG41066DG (EAL) domain protein HEC60_23285 ENOG4108UMI ABC transporter, permease HEC60_23295 ENOG4105D01 (LipO)protein HEC60_23305 ENOG4105NRA 50s ribosomal protein l31 type b HEC60_23310 ENOG4105YK5 50S ribosomal protein L36 HEC60_23325 ENOG4105GSJ Inner membrane protein ylaC HEC60_23330 ENOG4108UW5 maltose o-acetyltransferase HEC60_23340 ENOG4108UKR Biofilm formation regulator YbaJ HEC60_23345 ENOG4105BZS acriflavin resistance protein HEC60_23350 ENOG4105C1P efflux transporter, rnd family, mfp subunit HEC60_23355 ENOG4107XI7 Tetr family transcriptional regulator HEC60_23360 ENOG4105EGS Mechanosensitive ion channel HEC60_23365 ENOG4106428 Protein of unknown function (DUF2496) HEC60_23370 ENOG4108URS primosomal replication protein n'' HEC60_23375 ENOG4105WD1 Membrane HEC60_23385 ENOG4107QMP dna polymerase iii subunits gamma and tau HEC60_23390 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HEC60_23400 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HEC60_23405 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HEC60_23415 ENOG4107RE1 Inosine-guanosine kinase HEC60_23420 ENOG4105CKD glutathione-regulated potassium-efflux system protein HEC60_23425 ENOG4105EU0 Major facilitator Superfamily HEC60_23430 ENOG4105CGH 5'-nucleotidase HEC60_23435 ENOG4108Z66 YbaK ebsC protein HEC60_23440 ENOG4105MBR gumn family HEC60_23445 ENOG4105C59 p-type ATPase HEC60_23450 ENOG4108Z6Z Transcriptional regulator HEC60_23455 ENOG4105G5H Membrane HEC60_23460 ENOG4107QX8 SPFH domain, Band 7 family protein HEC60_23465 ENOG41083J0 (ABC) transporter HEC60_23470 ENOG4105C4B ABC transporter, permease HEC60_23475 ENOG4107QR8 Thioredoxin HEC60_23480 ENOG4105E1F short-chain dehydrogenase reductase HEC60_23485 ENOG4108UJV acyl-CoA thioesterase i HEC60_23490 ENOG4108I0Y (ABC) transporter HEC60_23495 ENOG4105CV6 ABC transporter, permease HEC60_23515 ENOG4105FCK Membrane HEC60_23525 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HEC60_23530 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HEC60_23535 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HEC60_23540 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HEC60_23545 ENOG4105C8N cysteinyl-tRNA synthetase HEC60_23550 ENOG4107P2S Transcriptional regulator HEC60_23555 ENOG4105CI1 PTS System HEC60_23560 ENOG4105WQ3 Rna-binding protein HEC60_23565 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HEC60_23570 ENOG4108WDE Fimbrial protein HEC60_23575 ENOG4105NJT Fimbrial protein HEC60_23580 ENOG4108AF8 Chaperone HEC60_23585 ENOG4105CW0 outer membrane usher protein HEC60_23590 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HEC60_23595 ENOG4108ZI2 Fimbrial protein HEC60_23600 ENOG4108Q9V regulatoR HEC60_23605 ENOG4106721 fimbriae Y protein HEC60_23615 ENOG4108KU3 Integrase HEC60_23670 ENOG41076J9 exonuclease VIII HEC60_23740 ENOG4105CDU Replicative dna helicase HEC60_23845 ENOG4108N0N Phage Terminase Large Subunit HEC60_23950 ENOG4105CI1 PTS System HEC60_23955 ENOG4105F5H Glycosyl Hydrolase Family 88 HEC60_23965 ENOG4108PU9 oligogalacturonate-specific porin HEC60_23975 ENOG4105CXN decarboxylase HEC60_23980 ENOG4105D5Q Arginine ornithine antiporter HEC60_24005 ENOG4106CQM replication HEC60_24060 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HEC60_24115 ENOG4108BUD transposase HEC60_24175 ENOG4108KTG Membrane protein, drug metabolite transporter HEC60_24190 ENOG4105CJN penicillin-binding protein HEC60_24250 ENOG4108RAV Conserved protein HEC60_24360 ENOG41073YN Protein of unknown function (DUF1380) HEC60_24390 ENOG4105MPK DNA polymerase III subunit theta HEC60_24420 ENOG41074AV Hok/gef family HEC60_24580 ENOG4105CZX twitching motility protein HEC60_24630 ENOG4105K5T PilT protein HEC60_24645 ENOG4107QHF type ii secretion system protein e HEC60_24745 ENOG4105F5W AtP-binding protein HEC60_24780 ENOG4105CAF HipA N-terminal domain protein HEC60_24845 ENOG4108MBX Secretion Protein HEC60_24895 ENOG4105GTN ParB Domain Protein Nuclease HEC60_24900 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HEC60_24945 ENOG4105Y7Q type iii secretion HEC60_24975 ENOG4105CMM transposase HEC60_24980 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HEC60_24990 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE HEC60_25000 ENOG4108M6W surface presentation of antigens protein SpaS HEC60_25005 ENOG4108TN6 type iii secretion HEC60_25010 ENOG4105U07 type iii secretion HEC60_25015 ENOG41075IY surface presentation of antigens protein SpaP HEC60_25020 ENOG4105T85 surface presentation of antigens protein HEC60_25035 ENOG4108JIR Flagellum-specific ATP synthase HEC60_25040 ENOG4108HR8 type iii secretion HEC60_25045 ENOG4108N8R Invasion protein HEC60_25055 ENOG41090HZ type iii secretion HEC60_25095 ENOG4105PBD transposase, IS3 IS911 family protein HEC60_25120 ENOG4108YAB Invasion protein HEC60_25215 ENOG4108RBT type iii secretion HEC60_25220 ENOG4106BTR HEC60_25225 ENOG4108RC9 Type III secretion system protein HEC60_25255 ENOG4106JVB Replication Protein HEC60_25295 ENOG41074AV Hok/gef family