locus-tag	class	description
HEC60_00010	COG2814	Major facilitator Superfamily
HEC60_00020	COG0579	oxidoreductase
HEC60_00025	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_00030	COG1113	amino acid transport
HEC60_00035	COG1802	Transcriptional regulator
HEC60_00040	COG2957	Belongs to the agmatine deiminase family
HEC60_00050	COG3753	Protein conserved in bacteria
HEC60_00055	COG1652	LysM domain
HEC60_00060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC60_00060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC60_00080	COG4565	transcriptional regulatory protein
HEC60_00085	COG3290	protein histidine kinase activity
HEC60_00090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HEC60_00095	COG1113	amino acid transport
HEC60_00100	COG0668	transmembrane transport
HEC60_00105	COG0477	Major facilitator Superfamily
HEC60_00130	COG0778	Nitroreductase
HEC60_00135	COG2315	Protein conserved in bacteria
HEC60_00155	COG0642	Histidine kinase
HEC60_00160	COG0745	RESPONSE REGULATOR receiver
HEC60_00175	COG4608	Belongs to the ABC transporter superfamily
HEC60_00180	COG0444	Belongs to the ABC transporter superfamily
HEC60_00190	COG0601	transmembrane transport
HEC60_00195	COG0747	negative chemotaxis
HEC60_00205	COG2977	Belongs to the P-Pant transferase superfamily
HEC60_00210	COG4771	TonB-dependent receptor
HEC60_00215	COG2382	esterase
HEC60_00220	COG3251	PFAM MbtH domain protein
HEC60_00225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HEC60_00225	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HEC60_00230	COG1120	ATPase activity
HEC60_00235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_00240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_00245	COG0477	Major facilitator Superfamily
HEC60_00250	COG4592	Periplasmic binding protein
HEC60_00255	COG1169	isochorismate synthase
HEC60_00260	COG1021	2,3-dihydroxybenzoate-AMP ligase
HEC60_00265	COG1535	isochorismatase
HEC60_00265	COG3433	isochorismatase activity
HEC60_00270	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_00275	COG2050	protein possibly involved in aromatic compounds catabolism
HEC60_00285	COG0700	Nucleoside recognition
HEC60_00290	COG3366	ferrous iron transmembrane transporter activity
HEC60_00295	COG1966	Carbon starvation protein
HEC60_00300	COG2879	small protein
HEC60_00315	COG1475	DNA binding
HEC60_00320	COG3969	phosphoadenosine phosphosulfate
HEC60_00325	COG0583	DNA-binding transcription factor activity
HEC60_00330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC60_00350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC60_00360	COG3719	Belongs to the RNase T2 family
HEC60_00365	COG3069	C4-dicarboxylate transmembrane transporter activity
HEC60_00385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC60_00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HEC60_00395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HEC60_00400	COG0583	DNA-binding transcription factor activity
HEC60_00410	COG2921	Belongs to the UPF0250 family
HEC60_00415	COG1686	Belongs to the peptidase S11 family
HEC60_00420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC60_00425	COG0772	Belongs to the SEDS family
HEC60_00430	COG0768	penicillin binding
HEC60_00440	COG0799	negative regulation of ribosome biogenesis
HEC60_00455	COG1466	dna polymerase III delta subunit
HEC60_00470	COG2888	peptidyl-tyrosine sulfation
HEC60_00475	COG1126	abc transporter atp-binding protein
HEC60_00480	COG0765	amino acid transport
HEC60_00485	COG0765	amino acid transport
HEC60_00495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HEC60_00500	COG4535	Mg2 and Co2 transporter CorC
HEC60_00505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HEC60_00510	COG1702	phosphate starvation-inducible protein PhoH
HEC60_00520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC60_00560	COG0367	asparagine synthase
HEC60_00565	COG0647	UMP catabolic process
HEC60_00570	COG1940	carbohydrate kinase activity
HEC60_00570	COG1846	Transcriptional regulator
HEC60_00575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC60_00585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_00585	COG2190	(PTS) system
HEC60_00585	COG1263	PTS System
HEC60_00605	COG0735	belongs to the Fur family
HEC60_00620	COG0596	Alpha beta hydrolase
HEC60_00625	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HEC60_00630	COG0033	Phosphoglucomutase
HEC60_00640	COG0531	amino acid
HEC60_00645	COG1982	Orn Lys Arg decarboxylase major
HEC60_00655	COG0745	RESPONSE REGULATOR receiver
HEC60_00660	COG2205	protein histidine kinase activity
HEC60_00670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HEC60_00675	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HEC60_00690	COG0415	Belongs to the DNA photolyase family
HEC60_00705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HEC60_00710	COG1984	allophanate hydrolase subunit 2
HEC60_00725	COG0372	Belongs to the citrate synthase family
HEC60_00730	COG2009	succinate dehydrogenase
HEC60_00735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HEC60_00740	COG1053	succinate dehydrogenase
HEC60_00745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEC60_00750	COG0567	Dehydrogenase, E1 component
HEC60_00755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC60_00765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC60_00770	COG1271	oxidase subunit
HEC60_00775	COG1294	oxidase, subunit
HEC60_00780	COG4890	Cyd operon protein YbgT
HEC60_00785	COG3790	cyd operon protein YbgE
HEC60_00790	COG0824	Thioesterase
HEC60_00795	COG0811	peptide transport
HEC60_00800	COG0848	biopolymer transport protein
HEC60_00815	COG2885	chlorophyll binding
HEC60_00820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HEC60_00860	COG3201	nicotinamide mononucleotide transporter
HEC60_00865	COG1230	cation diffusion facilitator family transporter
HEC60_00870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEC60_00880	COG2017	converts alpha-aldose to the beta-anomer
HEC60_00890	COG1085	galactose-1-phosphate uridylyltransferase
HEC60_00895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HEC60_00900	COG1119	ATPase activity
HEC60_00905	COG3585	molybdate ion transport
HEC60_00905	COG2005	Transcriptional regulator
HEC60_00915	COG0725	ABC transporter, periplasmic molybdate-binding protein
HEC60_00920	COG4149	molybdate abc transporter
HEC60_00930	COG0561	phosphatase activity
HEC60_00940	COG4677	pectinesterase activity
HEC60_00975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HEC60_00990	COG2226	methyltransferase
HEC60_01005	COG0642	Histidine kinase
HEC60_01010	COG0745	RESPONSE REGULATOR receiver
HEC60_01030	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC60_01040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HEC60_01050	COG0670	Belongs to the BI1 family
HEC60_01055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC60_01065	COG0842	Transport permease protein
HEC60_01070	COG0842	Transport permease protein
HEC60_01075	COG1131	(ABC) transporter
HEC60_01080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_01085	COG1309	transcriptional regulator
HEC60_01090	COG0513	Belongs to the DEAD box helicase family
HEC60_01100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEC60_01110	COG2252	PERMEase
HEC60_01120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC60_01135	COG0668	transmembrane transport
HEC60_01140	COG1126	abc transporter atp-binding protein
HEC60_01145	COG0765	amino acid transport
HEC60_01150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC60_01165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HEC60_01170	COG2194	sulfuric ester hydrolase activity
HEC60_01180	COG1321	iron dependent repressor
HEC60_01185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HEC60_01190	COG0667	Aldo Keto reductase
HEC60_01195	COG2723	6-phospho-beta-galactosidase activity
HEC60_01200	COG2188	Transcriptional regulator
HEC60_01205	COG1376	ErfK ybiS ycfS ynhG family protein
HEC60_01210	COG0488	(ABC) transporter
HEC60_01220	COG2271	Major facilitator Superfamily
HEC60_01235	COG0561	phosphatase activity
HEC60_01240	COG1882	Formate acetyltransferase
HEC60_01245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC60_01250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEC60_01255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEC60_01260	COG0303	'Molybdopterin
HEC60_01275	COG0747	negative chemotaxis
HEC60_01295	COG2233	PERMEase
HEC60_01315	COG0625	glutathione transferase activity
HEC60_01320	COG1686	Belongs to the peptidase S11 family
HEC60_01325	COG1349	DNA-binding transcription factor activity
HEC60_01330	COG0671	phosphoesterase, PA-phosphatase related
HEC60_01335	COG2814	Major facilitator Superfamily
HEC60_01340	COG0561	phosphatase activity
HEC60_01345	COG0738	Major facilitator superfamily
HEC60_01350	COG3226	Transcriptional regulator
HEC60_01355	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_01375	COG0778	Nitroreductase
HEC60_01390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEC60_01395	COG3842	ATPase activity
HEC60_01400	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEC60_01405	COG1177	transmembrane transport
HEC60_01425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HEC60_01430	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HEC60_01435	COG0745	RESPONSE REGULATOR receiver
HEC60_01440	COG2205	protein histidine kinase activity
HEC60_01450	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HEC60_01455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC60_01460	COG4160	amino acid transport
HEC60_01465	COG4215	(ABC) transporter
HEC60_01470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC60_01475	COG1126	abc transporter atp-binding protein
HEC60_01490	COG3023	N-Acetylmuramoyl-L-alanine amidase
HEC60_01510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC60_01515	COG0702	epimerase
HEC60_01520	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HEC60_01525	COG0028	Belongs to the TPP enzyme family
HEC60_01530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC60_01540	COG2431	L-lysine efflux transmembrane transporter activity
HEC60_01545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HEC60_01550	COG3593	DNA synthesis involved in DNA repair
HEC60_01555	COG2990	Protein conserved in bacteria
HEC60_01560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_01570	COG1278	Cold shock
HEC60_01580	COG0542	response to heat
HEC60_01600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HEC60_01605	COG4988	ABC transporter
HEC60_01610	COG0492	ferredoxin-NADP+ reductase activity
HEC60_01620	COG1178	ABC-type Fe3 transport system permease component
HEC60_01620	COG1674	ftsk spoiiie
HEC60_01630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HEC60_01640	COG0243	molybdopterin cofactor binding
HEC60_01645	COG0437	4 iron, 4 sulfur cluster binding
HEC60_01650	COG3302	dmso reductase anchor subunit
HEC60_01655	COG0477	Major facilitator Superfamily
HEC60_01660	COG0531	amino acid
HEC60_01665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC60_01670	COG1882	Formate acetyltransferase
HEC60_01675	COG2116	formate transmembrane transporter activity
HEC60_01680	COG1944	ATP diphosphatase activity
HEC60_01685	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HEC60_01700	COG0539	negative regulation of cytoplasmic translation
HEC60_01705	COG0776	regulation of translation
HEC60_01715	COG1132	(ABC) transporter
HEC60_01725	COG3214	Protein conserved in bacteria
HEC60_01760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEC60_01765	COG3173	Aminoglycoside phosphotransferase
HEC60_01770	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC60_01775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEC60_01785	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HEC60_01795	COG2989	Protein conserved in bacteria
HEC60_01800	COG3108	Peptidase M15
HEC60_01805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEC60_01810	COG1448	Aminotransferase
HEC60_01815	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC60_01820	COG0017	Asparaginyl-tRNA synthetase
HEC60_01825	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HEC60_01830	COG0308	aminopeptidase N
HEC60_01835	COG1116	anion transmembrane transporter activity
HEC60_01840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEC60_01850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HEC60_01855	COG0431	NADPH-dependent FMN reductase
HEC60_01870	COG3217	Mosc domain protein beta barrel domain protein
HEC60_01870	COG0633	Ferredoxin
HEC60_01880	COG0488	(ABC) transporter
HEC60_01885	COG2995	paraquat-inducible protein a
HEC60_01890	COG3008	intermembrane lipid transfer
HEC60_01890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC60_01895	COG3009	Protein conserved in bacteria
HEC60_01900	COG3130	regulation of translation
HEC60_01910	COG1067	ATP-dependent peptidase activity
HEC60_01930	COG3070	regulator of competence-specific genes
HEC60_01935	COG1289	transmembrane transporter activity
HEC60_01940	COG3304	Inner membrane component domain
HEC60_01945	COG0210	DNA helicase
HEC60_01955	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HEC60_01960	COG1832	CoA-binding protein
HEC60_01975	COG1881	PFAM PEBP family protein
HEC60_02020	COG0745	RESPONSE REGULATOR receiver
HEC60_02030	COG0670	Belongs to the BI1 family
HEC60_02120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC60_02385	COG0531	amino acid
HEC60_02390	COG2207	Transcriptional regulator
HEC60_02400	COG3247	response to pH
HEC60_02405	COG2771	luxR family
HEC60_02410	COG1982	Orn Lys Arg decarboxylase major
HEC60_02415	COG2200	EAL domain
HEC60_02420	COG3706	GGDEF domain
HEC60_02430	COG3710	Transcriptional regulator
HEC60_02450	COG3729	General stress protein
HEC60_02460	COG1309	transcriptional regulator
HEC60_02470	COG0506	proline dehydrogenase activity
HEC60_02470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HEC60_02470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HEC60_02475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEC60_02495	COG1702	phosphate starvation-inducible protein PhoH
HEC60_02505	COG1335	isochorismatase
HEC60_02515	COG0583	DNA-binding transcription factor activity
HEC60_02535	COG3381	protein complex oligomerization
HEC60_02585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HEC60_02605	COG5645	(Lipo)protein
HEC60_02620	COG1560	Kdo2-lipid A biosynthetic process
HEC60_02665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC60_02670	COG3132	Protein of unknown function, DUF480
HEC60_02675	COG0673	inositol 2-dehydrogenase activity
HEC60_02705	COG1558	bacterial-type flagellum-dependent cell motility
HEC60_02715	COG1749	Flagellar hook protein flgE
HEC60_02725	COG4786	Flagellar basal body rod
HEC60_02750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HEC60_02755	COG1530	ribonuclease E activity
HEC60_02760	COG0564	pseudouridine synthase activity
HEC60_02765	COG0424	maF-like protein
HEC60_02770	COG1399	metal-binding, possibly nucleic acid-binding protein
HEC60_02790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HEC60_02805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC60_02810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HEC60_02815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HEC60_02825	COG0470	DNA polymerase III
HEC60_02830	COG0084	hydrolase, TatD family'
HEC60_02835	COG1263	PTS System
HEC60_02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_02840	COG0537	adenosine 5'-monophosphoramidase activity
HEC60_02845	COG5633	Lipoprotein
HEC60_02850	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HEC60_02865	COG3150	esterase
HEC60_02870	COG1252	NADH dehydrogenase
HEC60_02875	COG3134	Outer membrane lipoprotein
HEC60_02880	COG1309	transcriptional regulator
HEC60_02890	COG1388	LysM domain
HEC60_02890	COG1376	ErfK ybiS ycfS ynhG family protein
HEC60_02895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HEC60_02900	COG4763	Acyl-transferase
HEC60_02905	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC60_02915	COG4591	ABC-type transport system involved in lipoprotein release permease component
HEC60_02935	COG1177	transmembrane transport
HEC60_02940	COG4690	dipeptidase activity
HEC60_02965	COG1943	Transposase
HEC60_02970	COG2850	peptidyl-arginine hydroxylation
HEC60_02975	COG2205	protein histidine kinase activity
HEC60_02985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HEC60_03005	COG1187	pseudouridine synthase activity
HEC60_03010	COG0538	isocitrate dehydrogenase activity
HEC60_03080	COG0671	phosphoesterase, PA-phosphatase related
HEC60_03135	COG3188	usher protein
HEC60_03140	COG3121	Chaperone
HEC60_03150	COG2200	EAL domain
HEC60_03175	COG2963	transposase activity
HEC60_03180	COG3547	Transposase (IS116 IS110 IS902 family)
HEC60_03215	COG0583	DNA-binding transcription factor activity
HEC60_03310	COG2826	transposase and inactivated derivatives, IS30 family
HEC60_03330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEC60_03355	COG0640	Transcriptional regulator
HEC60_03360	COG0431	NADPH-dependent FMN reductase
HEC60_03385	COG3459	Glycosyltransferase 36 associated
HEC60_03390	COG1278	Cold shock
HEC60_03410	COG0582	viral genome integration into host DNA
HEC60_03470	COG1942	4-Oxalocrotonate Tautomerase
HEC60_03475	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_03490	COG1116	anion transmembrane transporter activity
HEC60_03565	COG3539	Fimbrial protein
HEC60_03580	COG3121	Chaperone
HEC60_03585	COG3188	usher protein
HEC60_03590	COG2963	transposase activity
HEC60_03600	COG0531	amino acid
HEC60_03605	COG0583	DNA-binding transcription factor activity
HEC60_03615	COG0163	prenyltransferase activity
HEC60_03620	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_03625	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_03635	COG3732	PTS system glucitol sorbitol-specific
HEC60_03640	COG3730	PTS system glucitol sorbitol-specific
HEC60_03645	COG0673	inositol 2-dehydrogenase activity
HEC60_03735	COG2200	EAL domain
HEC60_03765	COG0791	NLP P60 protein
HEC60_03775	COG3217	Mosc domain protein beta barrel domain protein
HEC60_03775	COG0633	Ferredoxin
HEC60_03775	COG3217	Mosc domain protein beta barrel domain protein
HEC60_03775	COG0633	Ferredoxin
HEC60_03790	COG0584	glycerophosphoryl diester phosphodiesterase
HEC60_03825	COG0814	amino acid
HEC60_03835	COG2199	diguanylate cyclase activity
HEC60_03840	COG0538	isocitrate dehydrogenase activity
HEC60_03885	COG2391	methyltransferase activity
HEC60_03890	COG0425	Belongs to the sulfur carrier protein TusA family
HEC60_03900	COG0180	Tryptophanyl-tRNA synthetase
HEC60_03905	COG3182	Iron-regulated membrane protein
HEC60_03920	COG2199	diguanylate cyclase activity
HEC60_03920	COG2203	Gaf domain
HEC60_03955	COG3042	response to heat
HEC60_03965	COG3189	MarR family transcriptional regulator
HEC60_03970	COG0504	CTP synthase activity
HEC60_03975	COG2807	transmembrane transport
HEC60_03980	COG2207	Transcriptional regulator
HEC60_03990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC60_04000	COG2766	serine protein kinase
HEC60_04005	COG3713	MltA-interacting MipA family protein
HEC60_04015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEC60_04025	COG3139	Protein of unknown function (DUF1315)
HEC60_04035	COG1063	alcohol dehydrogenase
HEC60_04040	COG2271	Major facilitator Superfamily
HEC60_04045	COG1063	alcohol dehydrogenase
HEC60_04050	COG0191	fructose-bisphosphate aldolase activity
HEC60_04055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC60_04060	COG0667	Aldo Keto reductase
HEC60_04065	COG1349	DNA-binding transcription factor activity
HEC60_04070	COG2814	Major facilitator Superfamily
HEC60_04075	COG1335	isochorismatase
HEC60_04080	COG0252	asparaginase activity
HEC60_04085	COG0616	signal peptide processing
HEC60_04090	COG0778	Nitroreductase
HEC60_04100	COG0709	Synthesizes selenophosphate from selenide and ATP
HEC60_04105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HEC60_04120	COG0494	nUDIX hydrolase
HEC60_04125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC60_04130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HEC60_04135	COG2897	thiosulfate sulfurtransferase activity
HEC60_04140	COG4136	ATPase activity
HEC60_04145	COG4135	transport system, permease component
HEC60_04150	COG4134	Bacterial extracellular solute-binding protein
HEC60_04160	COG0708	Exodeoxyribonuclease III
HEC60_04170	COG3138	arginine N-succinyltransferase
HEC60_04180	COG3724	N-succinylarginine dihydrolase activity
HEC60_04190	COG3678	ATP-independent chaperone mediated protein folding
HEC60_04205	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC60_04210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC60_04215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC60_04220	COG1447	Phosphotransferase system cellobiose-specific component IIA
HEC60_04225	COG2169	Transcriptional regulator
HEC60_04225	COG1917	Cupin 2, conserved barrel domain protein
HEC60_04230	COG1486	melibiose metabolic process
HEC60_04250	COG1988	membrane-bound metal-dependent
HEC60_04255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC60_04280	COG3047	cAMP biosynthetic process
HEC60_04290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HEC60_04325	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC60_04405	COG2719	SpoVR family
HEC60_04420	COG3263	regulation of cellular component size
HEC60_04425	COG1619	proteins homologs of microcin C7 resistance protein MccF
HEC60_04445	COG2814	Major facilitator Superfamily
HEC60_04450	COG1414	Transcriptional regulator
HEC60_04480	COG2814	Major facilitator Superfamily
HEC60_04485	COG0583	DNA-binding transcription factor activity
HEC60_04490	COG0768	penicillin binding
HEC60_04495	COG2226	methyltransferase
HEC60_04510	COG3716	PTS system mannose fructose sorbose family IID component
HEC60_04515	COG3715	PTS system
HEC60_04520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_04520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_04525	COG1253	flavin adenine dinucleotide binding
HEC60_04530	COG2200	EAL domain
HEC60_04535	COG1760	l-serine dehydratase
HEC60_04555	COG0251	oxidation-reduction process
HEC60_04560	COG1199	ATP-dependent helicase activity
HEC60_04565	COG1214	PFAM Peptidase M22, glycoprotease
HEC60_04570	COG3065	identical protein binding
HEC60_04575	COG0318	PFAM AMP-dependent synthetase and ligase
HEC60_04580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HEC60_04590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HEC60_04595	COG2894	cell division
HEC60_04615	COG0134	indole-3-glycerol-phosphate synthase activity
HEC60_04615	COG0135	phosphoribosylanthranilate isomerase activity
HEC60_04620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HEC60_04620	COG0512	Glutamine amidotransferase of anthranilate synthase
HEC60_04625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HEC60_04635	COG0009	L-threonylcarbamoyladenylate synthase
HEC60_04645	COG1187	pseudouridine synthase activity
HEC60_04650	COG2211	Major facilitator Superfamily
HEC60_04655	COG1472	Belongs to the glycosyl hydrolase 3 family
HEC60_04660	COG2207	Transcriptional regulator
HEC60_04665	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HEC60_04670	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_04675	COG0616	signal peptide processing
HEC60_04710	COG0671	phosphoesterase, PA-phosphatase related
HEC60_04715	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HEC60_04720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HEC60_04730	COG0023	Translation Initiation Factor
HEC60_04740	COG1349	DNA-binding transcription factor activity
HEC60_04750	COG1024	Enoyl-CoA hydratase
HEC60_04755	COG5001	Diguanylate cyclase
HEC60_04765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC60_04765	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC60_04770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HEC60_04780	COG4172	Belongs to the ABC transporter superfamily
HEC60_04785	COG4172	Belongs to the ABC transporter superfamily
HEC60_04790	COG4171	peptide transport system, permease
HEC60_04805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HEC60_04810	COG1842	Phage shock protein A
HEC60_04820	COG1983	PspC domain protein
HEC60_04830	COG3106	COG3106 Predicted ATPase
HEC60_04895	COG2271	Major facilitator Superfamily
HEC60_04900	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HEC60_04905	COG0437	4 iron, 4 sulfur cluster binding
HEC60_04910	COG5557	Pfam Polysulphide reductase, NrfD
HEC60_04915	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HEC60_04920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC60_04925	COG1773	rubredoxin
HEC60_04935	COG0298	carbon dioxide binding
HEC60_04955	COG4948	Mandelate Racemase Muconate Lactonizing
HEC60_04960	COG2866	Carboxypeptidase
HEC60_04965	COG4166	transmembrane transport
HEC60_04970	COG3706	GGDEF domain
HEC60_04980	COG0840	transmembrane signaling receptor activity
HEC60_05000	COG0586	Pfam SNARE associated Golgi protein
HEC60_05005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC60_05010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HEC60_05010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC60_05010	COG1013	pyruvate-flavodoxin oxidoreductase activity
HEC60_05010	COG0674	pyruvate-flavodoxin oxidoreductase activity
HEC60_05025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC60_05055	COG3042	response to heat
HEC60_05060	COG3187	Heat shock protein
HEC60_05065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HEC60_05075	COG2911	Protein conserved in bacteria
HEC60_05085	COG3784	Protein of unknown function (DUF1318)
HEC60_05090	COG2207	Transcriptional regulator
HEC60_05095	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_05135	COG2030	dehydratase
HEC60_05135	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_05140	COG3396	Phenylacetate-CoA oxygenase
HEC60_05145	COG3460	Phenylacetate-CoA oxygenase
HEC60_05150	COG3396	Phenylacetate-CoA oxygenase
HEC60_05155	COG2151	metal-sulfur cluster biosynthetic enzyme
HEC60_05160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC60_05165	COG1024	Enoyl-CoA hydratase
HEC60_05170	COG1024	Enoyl-CoA hydratase
HEC60_05175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HEC60_05180	COG2050	protein possibly involved in aromatic compounds catabolism
HEC60_05185	COG0183	Belongs to the thiolase family
HEC60_05190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HEC60_05195	COG3327	negative regulation of DNA-templated transcription, initiation
HEC60_05200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC60_05210	COG1335	isochorismatase
HEC60_05225	COG1643	Atp-dependent helicase
HEC60_05230	COG1538	Outer membrane efflux protein
HEC60_05250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HEC60_05255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HEC60_05260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HEC60_05265	COG3038	cytochrome b561
HEC60_05270	COG3615	Tellurite resistance protein tehB
HEC60_05285	COG0321	lipoyl(octanoyl) transferase activity
HEC60_05285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEC60_05305	COG0840	transmembrane signaling receptor activity
HEC60_05310	COG0583	DNA-binding transcription factor activity
HEC60_05315	COG5383	Protein conserved in bacteria
HEC60_05320	COG2272	Belongs to the type-B carboxylesterase lipase family
HEC60_05330	COG0436	Aminotransferase
HEC60_05335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC60_05345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC60_05350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC60_05355	COG0500	methyltransferase
HEC60_05365	COG0697	spore germination
HEC60_05375	COG3135	benzoate transporter
HEC60_05380	COG1396	sequence-specific DNA binding
HEC60_05385	COG0826	peptidase U32
HEC60_05400	COG1294	oxidase, subunit
HEC60_05405	COG1271	oxidase subunit
HEC60_05420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC60_05425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HEC60_05430	COG3842	ATPase activity
HEC60_05435	COG1176	ABC-type spermidine putrescine transport system, permease component I
HEC60_05440	COG1177	transmembrane transport
HEC60_05445	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_05480	COG0747	negative chemotaxis
HEC60_05490	COG3238	Protein conserved in bacteria
HEC60_05495	COG1247	-acetyltransferase
HEC60_05505	COG2130	NADP-dependent
HEC60_05510	COG1802	Transcriptional regulator
HEC60_05515	COG4772	TonB-dependent receptor
HEC60_05540	COG0625	glutathione transferase activity
HEC60_05555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEC60_05560	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HEC60_05565	COG2181	nitrate reductase activity
HEC60_05570	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC60_05575	COG1140	nitrate reductase beta subunit
HEC60_05580	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC60_05585	COG2223	nitrite transmembrane transporter activity
HEC60_05620	COG0697	spore germination
HEC60_05630	COG0437	4 iron, 4 sulfur cluster binding
HEC60_05635	COG2864	formate dehydrogenase
HEC60_05650	COG1959	2 iron, 2 sulfur cluster binding
HEC60_05655	COG0488	(ABC) transporter
HEC60_05685	COG2239	Acts as a magnesium transporter
HEC60_05695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC60_05695	COG1017	nitric oxide dioxygenase activity
HEC60_05705	COG3539	Fimbrial protein
HEC60_05745	COG0628	permease
HEC60_05760	COG3300	MHYT domain
HEC60_05760	COG5001	Diguanylate cyclase
HEC60_05765	COG3591	Belongs to the peptidase S1B family
HEC60_05785	COG3158	transport of potassium into the cell
HEC60_05790	COG2814	Major facilitator Superfamily
HEC60_05795	COG0583	DNA-binding transcription factor activity
HEC60_05800	COG1940	carbohydrate kinase activity
HEC60_05805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HEC60_05820	COG0243	molybdopterin cofactor binding
HEC60_05835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC60_05850	COG4948	Mandelate Racemase Muconate Lactonizing
HEC60_05855	COG1063	alcohol dehydrogenase
HEC60_05860	COG0477	Major facilitator Superfamily
HEC60_05865	COG0246	Mannitol dehydrogenase
HEC60_05870	COG3272	Protein of unknown function (DUF1722)
HEC60_05875	COG1802	Transcriptional regulator
HEC60_05880	COG4221	oxidoreductase activity
HEC60_05895	COG0628	permease
HEC60_05915	COG2814	Major facilitator Superfamily
HEC60_05920	COG0697	spore germination
HEC60_05945	COG2814	Major facilitator Superfamily
HEC60_05955	COG0583	DNA-binding transcription factor activity
HEC60_05960	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_05980	COG2199	diguanylate cyclase activity
HEC60_05995	COG2814	Major facilitator Superfamily
HEC60_06005	COG4821	SIS domain
HEC60_06015	COG4821	SIS domain
HEC60_06020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_06025	COG3716	PTS system mannose fructose sorbose family IID component
HEC60_06040	COG2188	Transcriptional regulator
HEC60_06045	COG3781	membrane
HEC60_06075	COG0477	Major facilitator Superfamily
HEC60_06095	COG1609	Transcriptional regulator
HEC60_06105	COG2211	Major facilitator Superfamily
HEC60_06125	COG0641	radical SAM
HEC60_06130	COG3119	arylsulfatase activity
HEC60_06145	COG1116	anion transmembrane transporter activity
HEC60_06155	COG2197	response regulator
HEC60_06170	COG0346	lactoylglutathione lyase activity
HEC60_06190	COG1121	(ABC) transporter
HEC60_06210	COG2814	Major facilitator Superfamily
HEC60_06240	COG2169	Transcriptional regulator
HEC60_06245	COG0251	oxidation-reduction process
HEC60_06250	COG4628	conserved protein (DUF2132)
HEC60_06265	COG2840	Smr protein MutS2
HEC60_06275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC60_06295	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HEC60_06300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HEC60_06310	COG0531	amino acid
HEC60_06315	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_06320	COG3136	membrane protein required for alginate biosynthesis
HEC60_06325	COG0745	RESPONSE REGULATOR receiver
HEC60_06330	COG2205	protein histidine kinase activity
HEC60_06350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC60_06350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HEC60_06360	COG5339	Protein conserved in bacteria
HEC60_06365	COG1609	Transcriptional regulator
HEC60_06370	COG1263	PTS System
HEC60_06370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_06375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEC60_06385	COG0673	inositol 2-dehydrogenase activity
HEC60_06425	COG4659	FMN binding
HEC60_06435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HEC60_06440	COG3104	oligopeptide transport
HEC60_06445	COG0625	glutathione transferase activity
HEC60_06465	COG3895	Periplasmic Protein
HEC60_06480	COG3706	GGDEF domain
HEC60_06495	COG1566	PFAM secretion protein HlyD family protein
HEC60_06500	COG1289	transmembrane transporter activity
HEC60_06505	COG4989	oxidoreductase activity
HEC60_06515	COG3313	Fe-S protein
HEC60_06520	COG1309	transcriptional regulator
HEC60_06525	COG1902	pentaerythritol trinitrate reductase activity
HEC60_06530	COG0346	lactoylglutathione lyase activity
HEC60_06540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HEC60_06545	COG0791	NLP P60 protein
HEC60_06550	COG0604	alcohol dehydrogenase
HEC60_06555	COG1309	transcriptional regulator
HEC60_06565	COG2814	Major facilitator Superfamily
HEC60_06580	COG0583	DNA-binding transcription factor activity
HEC60_06585	COG2814	Major facilitator Superfamily
HEC60_06590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEC60_06595	COG0307	riboflavin synthase, alpha
HEC60_06625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HEC60_06655	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HEC60_06660	COG5001	Diguanylate cyclase
HEC60_06660	COG1716	ATPase activity
HEC60_06665	COG3706	GGDEF domain
HEC60_06680	COG4191	Histidine kinase
HEC60_06690	COG1126	abc transporter atp-binding protein
HEC60_06695	COG0765	amino acid transport
HEC60_06715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_06720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_06725	COG1120	ATPase activity
HEC60_06730	COG4774	siderophore transport
HEC60_06770	COG1376	ErfK ybiS ycfS ynhG family protein
HEC60_06785	COG0719	Fe-S assembly protein
HEC60_06790	COG0396	ATPase activity
HEC60_06795	COG0719	Fe-S assembly protein
HEC60_06800	COG0316	Belongs to the HesB IscA family
HEC60_06820	COG2261	transglycosylase associated protein
HEC60_06830	COG0425	Belongs to the sulfur carrier protein TusA family
HEC60_06835	COG0500	methyltransferase
HEC60_06840	COG2050	protein possibly involved in aromatic compounds catabolism
HEC60_06845	COG0277	FAD linked oxidase domain protein
HEC60_06845	COG0247	lactate metabolic process
HEC60_06850	COG0628	permease
HEC60_06860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HEC60_06860	COG0574	Belongs to the PEP-utilizing enzyme family
HEC60_06870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEC60_06875	COG4256	Hemin uptake protein
HEC60_06880	COG4771	TonB-dependent receptor
HEC60_06885	COG3720	iron ion transport
HEC60_06890	COG4558	Periplasmic binding protein
HEC60_06895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_06900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HEC60_06915	COG0791	NLP P60 protein
HEC60_06925	COG0386	Belongs to the glutathione peroxidase family
HEC60_06935	COG0776	regulation of translation
HEC60_06940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEC60_06940	COG0072	phenylalanine-tRNA ligase activity
HEC60_06980	COG3137	Salt-induced outer membrane protein
HEC60_06985	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC60_06990	COG3001	Fructosamine kinase
HEC60_07005	COG2350	Protein conserved in bacteria
HEC60_07020	COG3099	Belongs to the UPF0263 family
HEC60_07025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC60_07035	COG0444	Belongs to the ABC transporter superfamily
HEC60_07040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEC60_07045	COG0601	transmembrane transport
HEC60_07055	COG2095	MarC family integral membrane protein
HEC60_07060	COG1454	alcohol dehydrogenase
HEC60_07060	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_07080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HEC60_07085	COG0745	RESPONSE REGULATOR receiver
HEC60_07090	COG1752	Esterase of the alpha-beta hydrolase superfamily
HEC60_07100	COG0788	formyltetrahydrofolate deformylase activity
HEC60_07115	COG2181	nitrate reductase activity
HEC60_07120	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HEC60_07125	COG1140	nitrate reductase beta subunit
HEC60_07130	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HEC60_07135	COG2223	nitrite transmembrane transporter activity
HEC60_07140	COG3850	Histidine kinase
HEC60_07145	COG2197	response regulator
HEC60_07150	COG4932	domain protein
HEC60_07155	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HEC60_07160	COG0840	transmembrane signaling receptor activity
HEC60_07165	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HEC60_07170	COG0387	Pfam Sodium calcium exchanger
HEC60_07190	COG2890	protein-(glutamine-N5) methyltransferase activity
HEC60_07235	COG0012	GTP binding
HEC60_07270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEC60_07440	COG3121	Chaperone
HEC60_07445	COG3188	usher protein
HEC60_07640	COG2134	cdp-diacylglycerol pyrophosphatase
HEC60_07645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_07650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC60_07655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HEC60_07660	COG2226	methyltransferase
HEC60_07680	COG0148	phosphopyruvate hydratase activity
HEC60_07685	COG1227	inorganic diphosphatase activity
HEC60_07695	COG3005	denitrification pathway
HEC60_07700	COG4235	cytochrome complex assembly
HEC60_07700	COG3088	subunit of a heme lyase
HEC60_07705	COG4235	cytochrome complex assembly
HEC60_07705	COG3088	subunit of a heme lyase
HEC60_07740	COG4133	protoheme IX ABC transporter activity
HEC60_07755	COG2207	Transcriptional regulator
HEC60_07765	COG2211	Major facilitator Superfamily
HEC60_07780	COG0793	Belongs to the peptidase S41A family
HEC60_07790	COG1956	GAF domain-containing protein
HEC60_07795	COG2995	paraquat-inducible protein a
HEC60_07800	COG3008	intermembrane lipid transfer
HEC60_07805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HEC60_07805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HEC60_07825	COG2990	Protein conserved in bacteria
HEC60_07835	COG1560	Kdo2-lipid A biosynthetic process
HEC60_07845	COG1276	copper resistance
HEC60_07850	COG2372	response to copper ion
HEC60_07860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC60_07865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC60_07870	COG1770	oligopeptidase
HEC60_07875	COG2979	Protein of unknown function (DUF533)
HEC60_07885	COG0800	Aldolase
HEC60_07890	COG0129	dihydroxy-acid dehydratase activity
HEC60_07895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HEC60_07900	COG1737	Transcriptional regulator
HEC60_07905	COG0469	pyruvate kinase activity
HEC60_07910	COG1560	Kdo2-lipid A biosynthetic process
HEC60_07915	COG0739	heme binding
HEC60_07920	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HEC60_07930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC60_07955	COG0494	nUDIX hydrolase
HEC60_07960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HEC60_07965	COG1335	isochorismatase
HEC60_07970	COG1801	Protein of unknown function DUF72
HEC60_07975	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HEC60_07985	COG0500	methyltransferase
HEC60_07995	COG3102	Protein conserved in bacteria
HEC60_08005	COG2223	nitrite transmembrane transporter activity
HEC60_08010	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEC60_08030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HEC60_08045	COG3121	Chaperone
HEC60_08050	COG3188	usher protein
HEC60_08055	COG3539	Fimbrial protein
HEC60_08150	COG1528	Iron-storage protein
HEC60_08155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC60_08170	COG3437	response regulator, receiver
HEC60_08180	COG1528	Iron-storage protein
HEC60_08195	COG3318	Belongs to the UPF0149 family
HEC60_08195	COG3012	SEC-C Motif Domain Protein
HEC60_08200	COG3152	Membrane
HEC60_08215	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HEC60_08380	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEC60_08425	COG1846	Transcriptional regulator
HEC60_08515	COG2197	response regulator
HEC60_08525	COG2197	response regulator
HEC60_08585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HEC60_08600	COG0366	Alpha amylase catalytic
HEC60_08615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HEC60_08625	COG1696	Membrane protein involved in D-alanine export
HEC60_08655	COG4372	Transposase
HEC60_08660	COG3436	PFAM IS66 Orf2 family protein
HEC60_08960	COG4712	double-strand break repair protein
HEC60_08965	COG0629	single-stranded DNA binding
HEC60_09025	COG0582	viral genome integration into host DNA
HEC60_09030	COG1677	Flagellar hook-basal body complex protein FliE
HEC60_09045	COG1317	bacterial-type flagellum organization
HEC60_09065	COG1580	Controls the rotational direction of flagella during chemotaxis
HEC60_09085	COG1338	Plays a role in the flagellum-specific transport system
HEC60_09120	COG5475	Uncharacterized small protein (DUF2158)
HEC60_09125	COG2354	Protein conserved in bacteria
HEC60_09130	COG0697	spore germination
HEC60_09135	COG3727	T/G mismatch-specific endonuclease activity
HEC60_09140	COG0270	DNA (cytosine-5-)-methyltransferase activity
HEC60_09145	COG1418	mRNA catabolic process
HEC60_09150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC60_09160	COG1120	ATPase activity
HEC60_09165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_09185	COG0583	DNA-binding transcription factor activity
HEC60_09200	COG3228	Belongs to the MtfA family
HEC60_09285	COG0583	DNA-binding transcription factor activity
HEC60_09290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HEC60_09300	COG1811	Na channel or pump
HEC60_09305	COG0584	glycerophosphoryl diester phosphodiesterase
HEC60_09310	COG2271	Major facilitator Superfamily
HEC60_09320	COG0454	-acetyltransferase
HEC60_09325	COG0583	DNA-binding transcription factor activity
HEC60_09380	COG3153	acetyltransferase
HEC60_09405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HEC60_09410	COG0006	proline dipeptidase activity
HEC60_09430	COG1403	HNH endonuclease
HEC60_09475	COG0582	viral genome integration into host DNA
HEC60_09490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HEC60_09495	COG0702	epimerase
HEC60_09505	COG0667	Aldo Keto reductase
HEC60_09545	COG3121	Chaperone
HEC60_09550	COG3539	Fimbrial protein
HEC60_09595	COG0531	amino acid
HEC60_09600	COG0174	glutamine synthetase
HEC60_09605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HEC60_09610	COG1917	Cupin 2, conserved barrel domain protein
HEC60_09610	COG1396	sequence-specific DNA binding
HEC60_09615	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_09620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HEC60_09625	COG0534	Mate efflux family protein
HEC60_09640	COG1376	ErfK ybiS ycfS ynhG family protein
HEC60_09645	COG4771	TonB-dependent receptor
HEC60_09660	COG3721	Heme iron utilization protein
HEC60_09670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HEC60_09700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HEC60_09720	COG1289	transmembrane transporter activity
HEC60_09725	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC60_09735	COG2925	Exonuclease
HEC60_09740	COG0531	amino acid
HEC60_09750	COG0583	DNA-binding transcription factor activity
HEC60_09755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC60_09770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HEC60_09775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HEC60_09860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEC60_09870	COG1088	dTDP-glucose 4,6-dehydratase activity
HEC60_09885	COG0438	transferase activity, transferring glycosyl groups
HEC60_09890	COG2327	Polysaccharide pyruvyl transferase
HEC60_09895	COG2244	polysaccharide biosynthetic process
HEC60_09900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HEC60_09905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEC60_09915	COG0297	glycogen (starch) synthase activity
HEC60_09920	COG1051	belongs to the nudix hydrolase family
HEC60_09925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HEC60_09930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HEC60_09935	COG0110	maltose O-acetyltransferase activity
HEC60_09940	COG1216	Glycosyl transferase, family 2
HEC60_09950	COG0438	transferase activity, transferring glycosyl groups
HEC60_09955	COG0463	Glycosyl transferase, family 2
HEC60_09975	COG1253	flavin adenine dinucleotide binding
HEC60_09980	COG2982	Protein involved in outer membrane biogenesis
HEC60_09995	COG5002	protein histidine kinase activity
HEC60_09995	COG5001	Diguanylate cyclase
HEC60_09995	COG3447	MASE1 domain protein
HEC60_10000	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HEC60_10005	COG0443	Heat shock 70 kDa protein
HEC60_10030	COG0477	Major facilitator Superfamily
HEC60_10035	COG2205	protein histidine kinase activity
HEC60_10040	COG0745	RESPONSE REGULATOR receiver
HEC60_10060	COG3710	Transcriptional regulator
HEC60_10065	COG3121	Chaperone
HEC60_10090	COG1830	Aldolase
HEC60_10095	COG2211	Major facilitator Superfamily
HEC60_10100	COG1397	ADP-ribosylglycohydrolase
HEC60_10105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC60_10110	COG2188	Transcriptional regulator
HEC60_10115	COG0351	phosphomethylpyrimidine kinase
HEC60_10140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HEC60_10155	COG2252	PERMEase
HEC60_10160	COG0583	DNA-binding transcription factor activity
HEC60_10165	COG5455	response to cobalt ion
HEC60_10170	COG0489	protein tyrosine kinase activity
HEC60_10180	COG4807	Protein conserved in bacteria
HEC60_10200	COG3275	phosphorelay sensor kinase activity
HEC60_10205	COG0789	Transcriptional regulator
HEC60_10215	COG1174	glycine betaine transport
HEC60_10220	COG1125	glycine betaine transport
HEC60_10225	COG1174	glycine betaine transport
HEC60_10230	COG1732	Glycine betaine
HEC60_10235	COG1472	Belongs to the glycosyl hydrolase 3 family
HEC60_10240	COG0277	FAD linked oxidase domain protein
HEC60_10250	COG1686	Belongs to the peptidase S11 family
HEC60_10260	COG0586	Pfam SNARE associated Golgi protein
HEC60_10265	COG1538	Outer membrane efflux protein
HEC60_10270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HEC60_10275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEC60_10285	COG1346	cytolysis
HEC60_10290	COG0295	cytidine deaminase activity
HEC60_10295	COG2949	membrane
HEC60_10305	COG1129	ABC transporter
HEC60_10320	COG2311	Membrane
HEC60_10330	COG0477	Major facilitator Superfamily
HEC60_10340	COG4771	TonB-dependent receptor
HEC60_10345	COG0833	amino acid
HEC60_10350	COG0583	DNA-binding transcription factor activity
HEC60_10355	COG2855	membrane
HEC60_10375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC60_10375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HEC60_10375	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HEC60_10380	COG1105	Belongs to the carbohydrate kinase PfkB family
HEC60_10390	COG2814	Major facilitator Superfamily
HEC60_10395	COG2207	Transcriptional regulator
HEC60_10400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HEC60_10415	COG1312	Catalyzes the dehydration of D-mannonate
HEC60_10420	COG0246	Mannitol dehydrogenase
HEC60_10425	COG0523	cobalamin synthesis protein
HEC60_10430	COG0671	phosphoesterase, PA-phosphatase related
HEC60_10435	COG0791	NLP P60 protein
HEC60_10440	COG2200	EAL domain
HEC60_10445	COG4166	transmembrane transport
HEC60_10450	COG4174	ABC transporter (Permease)
HEC60_10455	COG4239	(ABC) transporter, permease
HEC60_10460	COG4172	Belongs to the ABC transporter superfamily
HEC60_10470	COG2814	Major facilitator Superfamily
HEC60_10480	COG1061	Type III restriction enzyme res subunit
HEC60_10510	COG0252	asparaginase activity
HEC60_10525	COG0659	secondary active sulfate transmembrane transporter activity
HEC60_10530	COG2239	Acts as a magnesium transporter
HEC60_10535	COG4615	Cyclic peptide transporter
HEC60_10540	COG3145	DNA-N1-methyladenine dioxygenase activity
HEC60_10545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HEC60_10545	COG2169	Transcriptional regulator
HEC60_10555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC60_10560	COG0642	Histidine kinase
HEC60_10560	COG2198	Histidine kinase
HEC60_10565	COG2197	response regulator
HEC60_10570	COG0784	Response regulator, receiver
HEC60_10570	COG2205	protein histidine kinase activity
HEC60_10615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC60_10620	COG0584	glycerophosphoryl diester phosphodiesterase
HEC60_10625	COG2271	Major facilitator Superfamily
HEC60_10630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC60_10640	COG0247	lactate metabolic process
HEC60_10655	COG0642	Histidine kinase
HEC60_10705	COG1169	isochorismate synthase
HEC60_10710	COG4575	ribosome binding
HEC60_10715	COG2153	protein acetylation
HEC60_10725	COG0784	Response regulator, receiver
HEC60_10725	COG0835	chemotaxis
HEC60_10735	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC60_10740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEC60_10750	COG0839	Belongs to the complex I subunit 6 family
HEC60_10770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEC60_10795	COG0583	DNA-binding transcription factor activity
HEC60_10800	COG0436	Aminotransferase
HEC60_10810	COG0490	domain, Protein
HEC60_10810	COG0471	metal ion transport
HEC60_10815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC60_10845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HEC60_10850	COG3959	Transketolase, thiamine diphosphate binding domain
HEC60_10855	COG3037	sugar-specific permease SgaT UlaA
HEC60_10865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_10870	COG1609	Transcriptional regulator
HEC60_10875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HEC60_10880	COG0622	Phosphoesterase
HEC60_10885	COG0625	glutathione transferase activity
HEC60_10890	COG0625	glutathione transferase activity
HEC60_10895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEC60_10900	COG1090	epimerase
HEC60_10905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HEC60_10920	COG4598	ABC transporter
HEC60_10925	COG4160	amino acid transport
HEC60_10945	COG0163	prenyltransferase activity
HEC60_10950	COG0833	amino acid
HEC60_10955	COG3457	Alanine racemase
HEC60_10960	COG0531	amino acid
HEC60_10970	COG3829	transcription factor binding
HEC60_10975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HEC60_10980	COG1286	toxin biosynthetic process
HEC60_10985	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HEC60_10990	COG0285	dihydrofolate synthase activity
HEC60_11000	COG0586	Pfam SNARE associated Golgi protein
HEC60_11010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEC60_11030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC60_11040	COG1917	Cupin 2, conserved barrel domain protein
HEC60_11040	COG4977	sequence-specific DNA binding
HEC60_11050	COG2211	Major facilitator Superfamily
HEC60_11055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEC60_11070	COG3101	peptidyl-lysine hydroxylation
HEC60_11075	COG0730	response to heat
HEC60_11100	COG2062	phosphohistidine phosphatase, SixA
HEC60_11115	COG3691	Protein conserved in bacteria
HEC60_11120	COG2067	long-chain fatty acid transport protein
HEC60_11135	COG3122	Protein conserved in bacteria
HEC60_11210	COG3501	Rhs element vgr protein
HEC60_11235	COG2885	chlorophyll binding
HEC60_11260	COG0583	DNA-binding transcription factor activity
HEC60_11265	COG0288	reversible hydration of carbon dioxide
HEC60_11275	COG2807	transmembrane transport
HEC60_11285	COG0436	Aminotransferase
HEC60_11290	COG3275	phosphorelay sensor kinase activity
HEC60_11295	COG3279	Response regulator of the LytR AlgR family
HEC60_11310	COG3961	Belongs to the TPP enzyme family
HEC60_11330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HEC60_11335	COG2200	EAL domain
HEC60_11335	COG2199	diguanylate cyclase activity
HEC60_11350	COG3415	Transposase
HEC60_11355	COG3415	Transposase
HEC60_11390	COG0583	DNA-binding transcription factor activity
HEC60_11395	COG0385	Bile acid
HEC60_11400	COG3530	Putative quorum-sensing-regulated virulence factor
HEC60_11425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_11435	COG2190	(PTS) system
HEC60_11450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HEC60_11455	COG4208	sulfate ABC transporter
HEC60_11460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HEC60_11465	COG4150	thiosulfate binding
HEC60_11470	COG1051	belongs to the nudix hydrolase family
HEC60_11475	COG2837	iron assimilation
HEC60_11495	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEC60_11535	COG1454	alcohol dehydrogenase
HEC60_11535	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_11545	COG1454	alcohol dehydrogenase
HEC60_11545	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_11550	COG1882	Formate acetyltransferase
HEC60_11555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC60_11565	COG4869	propanediol catabolic process
HEC60_11585	COG2207	Transcriptional regulator
HEC60_11590	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HEC60_11615	COG3192	ethanolamine utilization protein
HEC60_11620	COG1454	alcohol dehydrogenase
HEC60_11640	COG0280	phosphate acetyltransferase
HEC60_11655	COG4810	utilization protein
HEC60_11665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC60_11670	COG5342	invasion associated locus B
HEC60_11680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC60_11690	COG1393	Belongs to the ArsC family
HEC60_11705	COG0400	carboxylic ester hydrolase activity
HEC60_11710	COG1444	tRNA N-acetyltransferase activity
HEC60_11715	COG2321	neutral zinc metallopeptidase
HEC60_11720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HEC60_11725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HEC60_11730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC60_11735	COG2716	regulation of RNA biosynthetic process
HEC60_11740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HEC60_11745	COG1929	Belongs to the glycerate kinase type-1 family
HEC60_11750	COG2610	gluconate transmembrane transporter activity
HEC60_11755	COG3835	regulator
HEC60_11760	COG0628	permease
HEC60_11765	COG4783	chaperone-mediated protein folding
HEC60_11770	COG1393	Belongs to the ArsC family
HEC60_11785	COG1446	asparaginase
HEC60_11790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEC60_11800	COG2233	PERMEase
HEC60_11810	COG2723	6-phospho-beta-galactosidase activity
HEC60_11820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HEC60_11835	COG2200	EAL domain
HEC60_11850	COG0516	GMP reductase activity
HEC60_11850	COG0517	IMP dehydrogenase activity
HEC60_11855	COG1570	exodeoxyribonuclease VII activity
HEC60_11860	COG1645	bacterial-type flagellum-dependent swarming motility
HEC60_11865	COG3104	oligopeptide transport
HEC60_11880	COG2976	Protein conserved in bacteria
HEC60_11900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HEC60_11910	COG4953	penicillin-binding protein 1C
HEC60_11915	COG2373	Large extracellular alpha-helical protein
HEC60_11920	COG2897	thiosulfate sulfurtransferase activity
HEC60_11930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HEC60_11935	COG2975	iron-sulfur cluster assembly
HEC60_11940	COG0633	Ferredoxin
HEC60_11960	COG0822	iron-sulfur transferase activity
HEC60_11985	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC60_11990	COG3683	transport system, periplasmic component
HEC60_11995	COG3711	transcriptional antiterminator
HEC60_12000	COG1609	Transcriptional regulator
HEC60_12005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEC60_12015	COG2814	Major facilitator Superfamily
HEC60_12025	COG0477	Major facilitator Superfamily
HEC60_12025	COG2814	Major facilitator Superfamily
HEC60_12030	COG0457	Tetratricopeptide repeat
HEC60_12035	COG1940	carbohydrate kinase activity
HEC60_12045	COG1129	ABC transporter
HEC60_12050	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_12060	COG1069	ribulokinase activity
HEC60_12070	COG2259	Doxx family
HEC60_12075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HEC60_12080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HEC60_12080	COG1017	nitric oxide dioxygenase activity
HEC60_12085	COG0347	Belongs to the P(II) protein family
HEC60_12090	COG2204	response regulator
HEC60_12095	COG3170	Tfp pilus assembly protein FimV
HEC60_12100	COG2205	protein histidine kinase activity
HEC60_12105	COG0047	phosphoribosylformylglycinamidine synthase activity
HEC60_12105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HEC60_12120	COG0560	Phosphoserine phosphatase
HEC60_12125	COG1737	Transcriptional regulator
HEC60_12130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC60_12140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HEC60_12150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HEC60_12160	COG0681	Belongs to the peptidase S26 family
HEC60_12170	COG3086	response to oxidative stress
HEC60_12175	COG3026	antisigma factor binding
HEC60_12180	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HEC60_12195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HEC60_12200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HEC60_12205	COG0513	Belongs to the DEAD box helicase family
HEC60_12220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC60_12225	COG3118	belongs to the thioredoxin family
HEC60_12240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HEC60_12245	COG0477	Major facilitator Superfamily
HEC60_12265	COG0542	response to heat
HEC60_12280	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC60_12285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HEC60_12295	COG1605	Chorismate mutase
HEC60_12295	COG0077	Prephenate dehydratase
HEC60_12300	COG1605	Chorismate mutase
HEC60_12300	COG0287	Prephenate dehydrogenase
HEC60_12305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HEC60_12320	COG2199	diguanylate cyclase activity
HEC60_12325	COG2885	chlorophyll binding
HEC60_12380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC60_12415	COG4695	Portal protein
HEC60_12575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HEC60_12580	COG4137	Cytochrome C assembly protein
HEC60_12585	COG4536	flavin adenine dinucleotide binding
HEC60_12600	COG0497	DNA recombination
HEC60_12615	COG2867	negative regulation of translational initiation
HEC60_12640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_12705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC60_12715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC60_12740	COG1216	Glycosyl transferase, family 2
HEC60_12740	COG1442	glycosyl transferase family 8
HEC60_12805	COG1228	amidohydrolase
HEC60_12815	COG0583	DNA-binding transcription factor activity
HEC60_12820	COG1846	Transcriptional regulator
HEC60_12840	COG1289	transmembrane transporter activity
HEC60_12845	COG1538	Outer membrane efflux protein
HEC60_12850	COG3592	Divergent 4Fe-4S mono-cluster
HEC60_12855	COG2388	GCN5-related N-acetyl-transferase
HEC60_12885	COG1280	lysine exporter protein (LysE YggA)
HEC60_12890	COG3718	enzyme involved in inositol metabolism
HEC60_12900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC60_12905	COG0673	inositol 2-dehydrogenase activity
HEC60_12910	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_12915	COG1129	ABC transporter
HEC60_12925	COG0673	inositol 2-dehydrogenase activity
HEC60_12930	COG3962	Belongs to the TPP enzyme family
HEC60_12950	COG0402	S-adenosylhomocysteine deaminase activity
HEC60_12955	COG0549	Belongs to the carbamate kinase family
HEC60_12965	COG1304	FMN binding
HEC60_12970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC60_12980	COG0666	response to abiotic stimulus
HEC60_12985	COG0583	DNA-binding transcription factor activity
HEC60_12990	COG0401	homolog of Blt101
HEC60_12995	COG0640	Transcriptional regulator
HEC60_13000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC60_13020	COG4575	ribosome binding
HEC60_13030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HEC60_13035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEC60_13045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEC60_13050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HEC60_13060	COG4176	ABC-type proline glycine betaine transport system permease component
HEC60_13070	COG2814	Major facilitator Superfamily
HEC60_13075	COG1846	Transcriptional regulator
HEC60_13080	COG1566	PFAM secretion protein HlyD family protein
HEC60_13085	COG2814	Major facilitator Superfamily
HEC60_13100	COG1238	metal cluster binding
HEC60_13105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC60_13110	COG2823	Periplasmic or secreted lipoprotein
HEC60_13140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HEC60_13160	COG1546	Belongs to the CinA family
HEC60_13165	COG0803	Belongs to the bacterial solute-binding protein 9 family
HEC60_13170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC60_13180	COG2951	lytic endotransglycosylase activity
HEC60_13185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HEC60_13185	COG0517	IMP dehydrogenase activity
HEC60_13210	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC60_13215	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HEC60_13220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC60_13225	COG1609	Transcriptional regulator
HEC60_13235	COG2723	6-phospho-beta-galactosidase activity
HEC60_13240	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HEC60_13245	COG3604	Transcriptional regulator
HEC60_13255	COG3260	NADH ubiquinone oxidoreductase 20
HEC60_13260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HEC60_13265	COG3261	NADH dehydrogenase
HEC60_13265	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HEC60_13270	COG0651	ATP synthesis coupled electron transport
HEC60_13275	COG4237	Hydrogenase 4 membrane
HEC60_13280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HEC60_13285	COG0650	Formate hydrogenlyase subunit 4
HEC60_13290	COG0651	ATP synthesis coupled electron transport
HEC60_13295	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC60_13305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HEC60_13310	COG0298	carbon dioxide binding
HEC60_13315	COG0409	Hydrogenase expression formation protein
HEC60_13320	COG0309	Hydrogenase expression formation protein (HypE)
HEC60_13345	COG0583	DNA-binding transcription factor activity
HEC60_13355	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_13370	COG1902	pentaerythritol trinitrate reductase activity
HEC60_13385	COG0477	Major facilitator Superfamily
HEC60_13430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HEC60_13440	COG0529	Catalyzes the synthesis of activated sulfate
HEC60_13455	COG2234	aminopeptidase activity
HEC60_13475	COG0720	synthase
HEC60_13480	COG0644	oxidoreductase
HEC60_13485	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HEC60_13490	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HEC60_13495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HEC60_13500	COG2086	electron transfer activity
HEC60_13505	COG0477	Major facilitator Superfamily
HEC60_13510	COG0277	FAD linked oxidase domain protein
HEC60_13515	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_13520	COG2223	nitrite transmembrane transporter activity
HEC60_13525	COG1070	Carbohydrate kinase
HEC60_13530	COG0602	queuosine metabolic process
HEC60_13535	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HEC60_13540	COG1263	PTS System
HEC60_13540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_13540	COG2190	(PTS) system
HEC60_13565	COG3956	TIGRFAM MazG family protein
HEC60_13570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC60_13580	COG3437	response regulator, receiver
HEC60_13580	COG3850	Histidine kinase
HEC60_13580	COG2205	protein histidine kinase activity
HEC60_13580	COG4999	Histidine kinase
HEC60_13585	COG0716	FMN binding
HEC60_13590	COG0564	pseudouridine synthase activity
HEC60_13595	COG3098	single-species biofilm formation
HEC60_13610	COG1611	Belongs to the LOG family
HEC60_13615	COG0814	amino acid
HEC60_13620	COG1760	l-serine dehydratase
HEC60_13635	COG2363	Small membrane protein
HEC60_13640	COG0583	DNA-binding transcription factor activity
HEC60_13645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HEC60_13650	COG2166	iron-sulfur cluster assembly
HEC60_13655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HEC60_13660	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HEC60_13675	COG0860	N-Acetylmuramoyl-L-alanine amidase
HEC60_13680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HEC60_13680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HEC60_13685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEC60_13695	COG1025	Belongs to the peptidase M16 family
HEC60_13700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HEC60_13705	COG4967	type IV pilus modification protein PilV
HEC60_13715	COG4795	General secretion pathway protein
HEC60_13720	COG2165	general secretion pathway protein
HEC60_13755	COG0861	Integral membrane protein TerC family
HEC60_13765	COG0667	Aldo Keto reductase
HEC60_13770	COG0477	Major facilitator Superfamily
HEC60_13780	COG1609	Transcriptional regulator
HEC60_13790	COG1609	Transcriptional regulator
HEC60_13800	COG0583	DNA-binding transcription factor activity
HEC60_13805	COG1794	racemase activity, acting on amino acids and derivatives
HEC60_13810	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HEC60_13815	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_13825	COG0183	Belongs to the thiolase family
HEC60_13830	COG0583	DNA-binding transcription factor activity
HEC60_13840	COG0814	amino acid
HEC60_13845	COG0667	Aldo Keto reductase
HEC60_13865	COG3121	Chaperone
HEC60_13870	COG3188	usher protein
HEC60_13885	COG3104	oligopeptide transport
HEC60_13895	COG0531	amino acid
HEC60_13900	COG3710	Transcriptional regulator
HEC60_13935	COG4942	peptidase
HEC60_13955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HEC60_13980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HEC60_13990	COG1272	protein, Hemolysin III
HEC60_14000	COG1737	Transcriptional regulator
HEC60_14005	COG2723	6-phospho-beta-galactosidase activity
HEC60_14020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HEC60_14025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC60_14030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HEC60_14035	COG0006	proline dipeptidase activity
HEC60_14055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HEC60_14060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HEC60_14065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HEC60_14075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEC60_14075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEC60_14080	COG1703	isobutyryl-CoA mutase activity
HEC60_14085	COG1024	Enoyl-CoA hydratase
HEC60_14090	COG0427	acetyl-CoA hydrolase
HEC60_14095	COG0583	DNA-binding transcription factor activity
HEC60_14100	COG2968	Membrane
HEC60_14110	COG0668	transmembrane transport
HEC60_14115	COG0583	DNA-binding transcription factor activity
HEC60_14125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC60_14130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HEC60_14135	COG2271	Major facilitator Superfamily
HEC60_14140	COG0549	Belongs to the carbamate kinase family
HEC60_14145	COG0191	fructose-bisphosphate aldolase activity
HEC60_14150	COG0126	phosphoglycerate kinase activity
HEC60_14160	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HEC60_14165	COG0501	Belongs to the peptidase M48B family
HEC60_14170	COG0028	Belongs to the TPP enzyme family
HEC60_14180	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HEC60_14185	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_14190	COG2267	carboxylic ester hydrolase activity
HEC60_14215	COG1414	Transcriptional regulator
HEC60_14220	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_14235	COG2146	nitrite reductase [NAD(P)H] activity
HEC60_14240	COG0010	Belongs to the arginase family
HEC60_14255	COG1166	arginine decarboxylase activity
HEC60_14285	COG2814	Major facilitator Superfamily
HEC60_14290	COG3091	SprT-like family
HEC60_14295	COG2356	endonuclease I
HEC60_14300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HEC60_14320	COG2197	response regulator
HEC60_14325	COG2805	Type II/IV secretion system protein
HEC60_14330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HEC60_14335	COG0762	integral membrane protein
HEC60_14340	COG1872	DUF167
HEC60_14345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HEC60_14350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEC60_14355	COG2852	Protein conserved in bacteria
HEC60_14365	COG3171	Protein conserved in bacteria
HEC60_14375	COG1194	a g-specific adenine glycosylase
HEC60_14390	COG2211	Major facilitator Superfamily
HEC60_14395	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HEC60_14415	COG3052	prosthetic group binding
HEC60_14425	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC60_14430	COG3493	citrate carrier protein
HEC60_14440	COG4565	transcriptional regulatory protein
HEC60_14445	COG1982	Orn Lys Arg decarboxylase major
HEC60_14450	COG1811	Na channel or pump
HEC60_14480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC60_14485	COG0531	amino acid
HEC60_14490	COG3829	transcription factor binding
HEC60_14500	COG2271	Major facilitator Superfamily
HEC60_14505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HEC60_14515	COG0583	DNA-binding transcription factor activity
HEC60_14520	COG0754	glutathionylspermidine amidase activity
HEC60_14530	COG0625	glutathione transferase activity
HEC60_14540	COG0667	Aldo Keto reductase
HEC60_14545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HEC60_14550	COG1757	Na H antiporter
HEC60_14555	COG1609	Transcriptional regulator
HEC60_14575	COG0848	biopolymer transport protein
HEC60_14585	COG0626	cystathionine gamma-synthase activity
HEC60_14595	COG2207	Transcriptional regulator
HEC60_14600	COG1979	alcohol dehydrogenase
HEC60_14605	COG0656	L-ascorbic acid biosynthetic process
HEC60_14610	COG1032	radical SAM domain protein
HEC60_14615	COG2132	Multicopper oxidase
HEC60_14630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HEC60_14635	COG3111	PFAM Bacterial OB fold (BOF) protein
HEC60_14645	COG0642	Histidine kinase
HEC60_14650	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC60_14655	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HEC60_14660	COG0187	DNA topoisomerase II activity
HEC60_14665	COG3150	esterase
HEC60_14670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HEC60_14675	COG3151	Protein conserved in bacteria
HEC60_14680	COG0494	nUDIX hydrolase
HEC60_14685	COG1538	Outer membrane efflux protein
HEC60_14695	COG0754	glutathionylspermidine amidase activity
HEC60_14700	COG3384	dioxygenase
HEC60_14730	COG3025	triphosphatase activity
HEC60_14735	COG4991	sh3 domain protein
HEC60_14740	COG0617	tRNA 3'-terminal CCA addition
HEC60_14750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HEC60_14765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HEC60_14770	COG0358	DNA primase activity
HEC60_14795	COG3663	DNA glycosylase
HEC60_14810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HEC60_14830	COG1464	Belongs to the NlpA lipoprotein family
HEC60_14835	COG2011	ABC-type metal ion transport system permease component
HEC60_14840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEC60_14850	COG0626	cystathionine gamma-synthase activity
HEC60_14860	COG2375	cellular response to nickel ion
HEC60_14865	COG1695	Transcriptional regulator
HEC60_14870	COG0840	transmembrane signaling receptor activity
HEC60_14875	COG0840	transmembrane signaling receptor activity
HEC60_14890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HEC60_14895	COG1609	Transcriptional regulator
HEC60_14900	COG3250	beta-galactosidase activity
HEC60_14905	COG2731	YhcH YjgK YiaL family protein
HEC60_14910	COG0531	amino acid
HEC60_14920	COG3408	Glycogen debranching enzyme
HEC60_14920	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HEC60_14940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_14945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_14950	COG1129	ABC transporter
HEC60_14960	COG1070	Carbohydrate kinase
HEC60_14975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HEC60_14975	COG1902	pentaerythritol trinitrate reductase activity
HEC60_14985	COG1451	nucleotide metabolic process
HEC60_14990	COG0673	inositol 2-dehydrogenase activity
HEC60_15005	COG2721	sulfolactate sulfo-lyase activity
HEC60_15015	COG2271	Major facilitator Superfamily
HEC60_15020	COG2186	Transcriptional regulator
HEC60_15025	COG0586	Pfam SNARE associated Golgi protein
HEC60_15035	COG1422	Protein of unknown function (DUF1090)
HEC60_15040	COG4575	ribosome binding
HEC60_15045	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HEC60_15055	COG2259	Doxx family
HEC60_15060	COG0435	Glutathione S-transferase
HEC60_15065	COG3152	Membrane
HEC60_15070	COG0583	DNA-binding transcription factor activity
HEC60_15075	COG1741	Belongs to the pirin family
HEC60_15085	COG0814	amino acid
HEC60_15095	COG1760	l-serine dehydratase
HEC60_15100	COG1882	Formate acetyltransferase
HEC60_15115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEC60_15120	COG0583	DNA-binding transcription factor activity
HEC60_15130	COG1349	DNA-binding transcription factor activity
HEC60_15140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_15150	COG3716	PTS system mannose fructose sorbose family IID component
HEC60_15155	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_15160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HEC60_15165	COG2222	sugar isomerase
HEC60_15175	COG1263	PTS System
HEC60_15175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_15180	COG0436	Aminotransferase
HEC60_15190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HEC60_15195	COG3107	peptidoglycan biosynthetic process
HEC60_15200	COG0792	nuclease activity
HEC60_15210	COG2823	Periplasmic or secreted lipoprotein
HEC60_15215	COG0701	Predicted permease
HEC60_15220	COG0702	epimerase
HEC60_15235	COG3153	acetyltransferase
HEC60_15240	COG3154	lipid carrier protein
HEC60_15245	COG0826	peptidase U32
HEC60_15250	COG0826	peptidase U32
HEC60_15255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HEC60_15260	COG0814	amino acid
HEC60_15265	COG0513	Belongs to the DEAD box helicase family
HEC60_15285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HEC60_15300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HEC60_15305	COG0195	Participates in both transcription termination and antitermination
HEC60_15350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HEC60_15355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEC60_15360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HEC60_15375	COG1534	Rna-binding protein
HEC60_15385	COG2027	D-alanyl-D-alanine carboxypeptidase
HEC60_15395	COG0697	spore germination
HEC60_15405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HEC60_15410	COG0142	geranyltranstransferase activity
HEC60_15415	COG3423	Transcriptional regulator
HEC60_15425	COG5007	Belongs to the BolA IbaG family
HEC60_15430	COG3113	response to antibiotic
HEC60_15435	COG2854	intermembrane phospholipid transfer
HEC60_15440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HEC60_15445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HEC60_15450	COG1127	ABC transporter
HEC60_15455	COG0530	calcium, potassium:sodium antiporter activity
HEC60_15460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HEC60_15460	COG0517	IMP dehydrogenase activity
HEC60_15465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HEC60_15470	COG3117	lipopolysaccharide transmembrane transporter activity
HEC60_15475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HEC60_15480	COG1137	ATPase activity
HEC60_15485	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HEC60_15505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_15515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HEC60_15520	COG5002	protein histidine kinase activity
HEC60_15520	COG0784	Response regulator, receiver
HEC60_15520	COG2198	Histidine kinase
HEC60_15525	COG1242	4 iron, 4 sulfur cluster binding
HEC60_15530	COG0067	glutamate synthase
HEC60_15530	COG0069	glutamate synthase activity
HEC60_15530	COG0070	glutamate synthase
HEC60_15535	COG0493	'glutamate synthase
HEC60_15540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HEC60_15550	COG0583	DNA-binding transcription factor activity
HEC60_15555	COG2731	YhcH YjgK YiaL family protein
HEC60_15580	COG2969	positive regulation of protein catabolic process
HEC60_15585	COG0625	glutathione transferase activity
HEC60_15600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HEC60_15605	COG3105	Protein conserved in bacteria
HEC60_15610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEC60_15615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEC60_15640	COG2732	(Barnase) inhibitor
HEC60_15650	COG1289	transmembrane transporter activity
HEC60_15665	COG0583	DNA-binding transcription factor activity
HEC60_15670	COG1349	DNA-binding transcription factor activity
HEC60_15690	COG0738	Major facilitator superfamily
HEC60_15695	COG0235	Class ii aldolase
HEC60_15700	COG0312	modulator of DNA gyrase
HEC60_15705	COG3164	Protein of unknown function
HEC60_15710	COG1530	ribonuclease E activity
HEC60_15720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HEC60_15725	COG1792	Involved in formation and maintenance of cell shape
HEC60_15730	COG1077	Cell shape determining protein MreB Mrl
HEC60_15740	COG2200	EAL domain
HEC60_15740	COG2199	diguanylate cyclase activity
HEC60_15745	COG0604	alcohol dehydrogenase
HEC60_15755	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HEC60_15760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HEC60_15765	COG0511	ligase activity, forming carbon-carbon bonds
HEC60_15770	COG0439	Biotin carboxylase
HEC60_15775	COG3924	membrane
HEC60_15780	COG4145	pantothenate transmembrane transporter activity
HEC60_15810	COG1309	transcriptional regulator
HEC60_15815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_15820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC60_15830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HEC60_15835	COG4597	amino acid ABC transporter
HEC60_15840	COG0765	amino acid transport
HEC60_15845	COG1126	abc transporter atp-binding protein
HEC60_15880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HEC60_15900	COG0551	DNA topoisomerase type I activity
HEC60_15910	COG0758	DNA mediated transformation
HEC60_15940	COG3036	rescue of stalled ribosome
HEC60_15945	COG0789	Transcriptional regulator
HEC60_15960	COG0202	RNA polymerase activity
HEC60_15970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HEC60_15985	COG0201	protein transport
HEC60_16000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HEC60_16045	COG0255	Belongs to the universal ribosomal protein uL29 family
HEC60_16050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HEC60_16065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HEC60_16090	COG0051	transcription antitermination factor activity, RNA binding
HEC60_16100	COG3409	Peptidoglycan-binding domain 1 protein
HEC60_16100	COG3267	Type II secretory pathway component ExeA
HEC60_16110	COG1450	Type ii and iii secretion system protein
HEC60_16115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC60_16120	COG1459	type II secretion system
HEC60_16125	COG2165	general secretion pathway protein
HEC60_16135	COG4795	General secretion pathway protein
HEC60_16140	COG3156	type II secretion system protein K
HEC60_16145	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HEC60_16160	COG2193	ferroxidase activity
HEC60_16210	COG2964	Protein conserved in bacteria
HEC60_16215	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC60_16225	COG1047	Peptidyl-prolyl cis-trans
HEC60_16230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HEC60_16235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEC60_16235	COG0475	glutathione-regulated potassium exporter activity
HEC60_16245	COG0488	(ABC) transporter
HEC60_16250	COG0429	hydrolase of the alpha beta-hydrolase fold
HEC60_16260	COG3954	Phosphoribulokinase
HEC60_16265	COG1765	OsmC-like protein
HEC60_16275	COG1289	transmembrane transporter activity
HEC60_16285	COG0512	Glutamine amidotransferase of anthranilate synthase
HEC60_16305	COG0738	Major facilitator superfamily
HEC60_16310	COG0402	S-adenosylhomocysteine deaminase activity
HEC60_16315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HEC60_16340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HEC60_16345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HEC60_16350	COG3266	domain, Protein
HEC60_16360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEC60_16365	COG4796	Type ii and iii secretion system protein
HEC60_16385	COG4972	Pilus assembly protein
HEC60_16390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HEC60_16395	COG0494	nUDIX hydrolase
HEC60_16405	COG1011	Hydrolase
HEC60_16410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HEC60_16430	COG0745	RESPONSE REGULATOR receiver
HEC60_16435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HEC60_16440	COG2183	response to ionizing radiation
HEC60_16445	COG1918	ferrous iron import across plasma membrane
HEC60_16480	COG2610	gluconate transmembrane transporter activity
HEC60_16485	COG1640	4-alpha-glucanotransferase
HEC60_16490	COG0058	SHG alpha-glucan phosphorylase activity
HEC60_16500	COG1349	DNA-binding transcription factor activity
HEC60_16515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HEC60_16520	COG0058	SHG alpha-glucan phosphorylase activity
HEC60_16535	COG1523	belongs to the glycosyl hydrolase 13 family
HEC60_16545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HEC60_16550	COG2610	gluconate transmembrane transporter activity
HEC60_16555	COG3265	gluconokinase activity
HEC60_16560	COG1609	Transcriptional regulator
HEC60_16565	COG1741	Belongs to the pirin family
HEC60_16570	COG0673	inositol 2-dehydrogenase activity
HEC60_16575	COG1247	-acetyltransferase
HEC60_16580	COG0405	Gamma-glutamyltransferase
HEC60_16590	COG0584	glycerophosphoryl diester phosphodiesterase
HEC60_16615	COG0410	ABC transporter
HEC60_16620	COG0411	ABC transporter
HEC60_16635	COG0683	leucine binding
HEC60_16645	COG0683	leucine binding
HEC60_16650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HEC60_16660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HEC60_16665	COG2177	Part of the ABC transporter FtsEX involved in
HEC60_16670	COG2884	Cell division ATP-binding protein ftsE
HEC60_16675	COG0552	protein localization to endoplasmic reticulum
HEC60_16680	COG0742	ribosomal rna small subunit methyltransferase
HEC60_16685	COG3776	membrane
HEC60_16695	COG3714	YhhN family
HEC60_16710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HEC60_16775	COG2081	HI0933 family
HEC60_16780	COG0306	phosphate transporter
HEC60_16790	COG0589	response to stress
HEC60_16810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HEC60_16815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC60_16825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC60_16830	COG2207	Transcriptional regulator
HEC60_16835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC60_16840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_16845	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_16850	COG1538	Outer membrane efflux protein
HEC60_16855	COG0745	RESPONSE REGULATOR receiver
HEC60_16860	COG5002	protein histidine kinase activity
HEC60_16885	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_16890	COG0583	DNA-binding transcription factor activity
HEC60_16895	COG1295	ribonuclease BN
HEC60_16900	COG0477	Major facilitator Superfamily
HEC60_16905	COG2982	Protein involved in outer membrane biogenesis
HEC60_16910	COG2200	EAL domain
HEC60_16920	COG0612	Peptidase, M16
HEC60_16930	COG2200	EAL domain
HEC60_16930	COG2199	diguanylate cyclase activity
HEC60_16935	COG3118	belongs to the thioredoxin family
HEC60_16935	COG0457	Tetratricopeptide repeat
HEC60_16980	COG0626	cystathionine gamma-synthase activity
HEC60_16985	COG0814	amino acid
HEC60_16990	COG2204	response regulator
HEC60_17000	COG3620	sequence-specific DNA binding
HEC60_17005	COG4608	Belongs to the ABC transporter superfamily
HEC60_17010	COG0444	Belongs to the ABC transporter superfamily
HEC60_17015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HEC60_17020	COG0601	transmembrane transport
HEC60_17025	COG0747	negative chemotaxis
HEC60_17055	COG2223	nitrite transmembrane transporter activity
HEC60_17060	COG5571	outer membrane autotransporter
HEC60_17065	COG2818	Glycosylase
HEC60_17070	COG0456	acetyltransferase
HEC60_17075	COG0243	molybdopterin cofactor binding
HEC60_17080	COG2885	chlorophyll binding
HEC60_17095	COG2944	sequence-specific DNA binding
HEC60_17100	COG1278	Cold shock
HEC60_17105	COG0488	(ABC) transporter
HEC60_17110	COG0751	glycine-tRNA ligase activity
HEC60_17125	COG3274	enterobacterial common antigen metabolic process
HEC60_17130	COG1070	Carbohydrate kinase
HEC60_17140	COG4213	ABC transporter substrate-binding protein
HEC60_17150	COG4214	carbohydrate transport
HEC60_17155	COG2207	Transcriptional regulator
HEC60_17155	COG1609	Transcriptional regulator
HEC60_17160	COG2992	FlgJ-related protein
HEC60_17165	COG0366	Alpha amylase catalytic
HEC60_17170	COG3977	Valine--pyruvate aminotransferase
HEC60_17200	COG2211	Major facilitator Superfamily
HEC60_17210	COG1598	PFAM Uncharacterised protein family UPF0150
HEC60_17220	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_17225	COG1454	alcohol dehydrogenase
HEC60_17230	COG3276	selenocysteine insertion sequence binding
HEC60_17240	COG0625	glutathione transferase activity
HEC60_17245	COG1566	PFAM secretion protein HlyD family protein
HEC60_17255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_17255	COG2213	PTS system mannitol-specific
HEC60_17265	COG3722	fumarate hydratase activity
HEC60_17280	COG2186	Transcriptional regulator
HEC60_17290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HEC60_17305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HEC60_17310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HEC60_17315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HEC60_17320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HEC60_17325	COG4942	peptidase
HEC60_17330	COG2861	carbohydrate metabolic process
HEC60_17335	COG0463	Glycosyl transferase, family 2
HEC60_17355	COG0859	PFAM glycosyl transferase family 9
HEC60_17360	COG0859	PFAM glycosyl transferase family 9
HEC60_17370	COG3307	-O-antigen
HEC60_17385	COG0859	PFAM glycosyl transferase family 9
HEC60_17390	COG0438	transferase activity, transferring glycosyl groups
HEC60_17395	COG0438	transferase activity, transferring glycosyl groups
HEC60_17400	COG1216	Glycosyl transferase, family 2
HEC60_17410	COG1519	Transferase
HEC60_17420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HEC60_17425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HEC60_17430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HEC60_17445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HEC60_17450	COG0756	dUTP diphosphatase activity
HEC60_17470	COG1561	YicC-like family, N-terminal region
HEC60_17475	COG2860	membrane
HEC60_17485	COG0194	GDP metabolic process
HEC60_17495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HEC60_17500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC60_17505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HEC60_17510	COG1494	fructose-1,6-bisphosphatase
HEC60_17520	COG3152	Membrane
HEC60_17570	COG0583	DNA-binding transcription factor activity
HEC60_17585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HEC60_17605	COG1309	transcriptional regulator
HEC60_17615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_17615	COG1263	PTS System
HEC60_17620	COG0697	spore germination
HEC60_17650	COG2188	Transcriptional regulator
HEC60_17690	COG2197	response regulator
HEC60_17695	COG0440	acetolactate synthase activity
HEC60_17700	COG0028	Belongs to the TPP enzyme family
HEC60_17715	COG2814	Major facilitator Superfamily
HEC60_17720	COG0641	radical SAM
HEC60_17730	COG2149	membrane
HEC60_17750	COG5645	(Lipo)protein
HEC60_17755	COG0823	Involved in the tonB-independent uptake of proteins
HEC60_17760	COG2271	Major facilitator Superfamily
HEC60_17765	COG4948	Mandelate Racemase Muconate Lactonizing
HEC60_17770	COG0800	Aldolase
HEC60_17775	COG3734	2-keto-3-deoxy-galactonokinase
HEC60_17780	COG2186	Transcriptional regulator
HEC60_17800	COG0561	phosphatase activity
HEC60_17815	COG0592	DNA-directed DNA polymerase activity
HEC60_17825	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HEC60_17840	COG0706	membrane insertase activity
HEC60_17850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC60_17855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HEC60_17860	COG1121	(ABC) transporter
HEC60_17880	COG2091	lysine biosynthetic process via aminoadipic acid
HEC60_17885	COG0431	NADPH-dependent FMN reductase
HEC60_17890	COG2252	PERMEase
HEC60_17895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HEC60_17900	COG0704	Plays a role in the regulation of phosphate uptake
HEC60_17910	COG0581	inorganic phosphate transmembrane transporter activity
HEC60_17915	COG0573	inorganic phosphate transmembrane transporter activity
HEC60_17920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HEC60_17945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HEC60_17950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HEC60_17970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HEC60_17980	COG0356	it plays a direct role in the translocation of protons across the membrane
HEC60_17985	COG3312	ion transport
HEC60_17990	COG0357	Ribosomal RNA small subunit methyltransferase G
HEC60_18000	COG0716	FMN binding
HEC60_18005	COG1522	sequence-specific DNA binding
HEC60_18035	COG1129	ABC transporter
HEC60_18040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_18050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC60_18055	COG1609	Transcriptional regulator
HEC60_18060	COG0477	Major facilitator Superfamily
HEC60_18065	COG2186	Transcriptional regulator
HEC60_18090	COG1763	Mo-molybdopterin cofactor biosynthetic process
HEC60_18095	COG0746	molybdenum cofactor guanylyltransferase activity
HEC60_18100	COG3084	Protein conserved in bacteria
HEC60_18105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HEC60_18115	COG0204	Acyl-transferase
HEC60_18130	COG3078	GTPase activator activity
HEC60_18135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HEC60_18145	COG2204	response regulator
HEC60_18150	COG3852	Histidine kinase
HEC60_18165	COG2188	Transcriptional regulator
HEC60_18170	COG1082	Xylose isomerase domain protein TIM barrel
HEC60_18175	COG2271	Major facilitator Superfamily
HEC60_18185	COG2771	luxR family
HEC60_18200	COG1011	Hydrolase
HEC60_18210	COG1490	D-aminoacyl-tRNA deacylase activity
HEC60_18215	COG0456	acetyltransferase
HEC60_18220	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HEC60_18235	COG2864	formate dehydrogenase
HEC60_18240	COG0437	4 iron, 4 sulfur cluster binding
HEC60_18265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HEC60_18280	COG1454	alcohol dehydrogenase
HEC60_18305	COG4977	sequence-specific DNA binding
HEC60_18305	COG1917	Cupin 2, conserved barrel domain protein
HEC60_18315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HEC60_18325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HEC60_18330	COG2258	MOSC domain
HEC60_18335	COG2205	protein histidine kinase activity
HEC60_18340	COG0745	RESPONSE REGULATOR receiver
HEC60_18345	COG3678	ATP-independent chaperone mediated protein folding
HEC60_18355	COG0205	6-phosphofructokinase activity
HEC60_18360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HEC60_18365	COG1575	Belongs to the MenA family. Type 1 subfamily
HEC60_18380	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HEC60_18385	COG1609	Transcriptional regulator
HEC60_18390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HEC60_18405	COG0626	cystathionine gamma-synthase activity
HEC60_18410	COG0460	homoserine dehydrogenase
HEC60_18410	COG0527	aspartate kinase activity
HEC60_18425	COG0697	spore germination
HEC60_18440	COG2258	MOSC domain
HEC60_18450	COG0157	Belongs to the NadC ModD family
HEC60_18455	COG4106	trans-aconitate 2-methyltransferase activity
HEC60_18460	COG1120	ATPase activity
HEC60_18485	COG2211	Major facilitator Superfamily
HEC60_18490	COG1501	Belongs to the glycosyl hydrolase 31 family
HEC60_18500	COG1486	melibiose metabolic process
HEC60_18505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_18505	COG1263	PTS System
HEC60_18510	COG2982	Protein involved in outer membrane biogenesis
HEC60_18515	COG2233	PERMEase
HEC60_18520	COG0786	glutamate:sodium symporter activity
HEC60_18535	COG3074	FtsZ-dependent cytokinesis
HEC60_18595	COG3085	chromosome segregation
HEC60_18600	COG0606	chelatase, subunit chli
HEC60_18615	COG3978	acetolactate synthase activity
HEC60_18635	COG0583	DNA-binding transcription factor activity
HEC60_18655	COG0248	Ppx GppA phosphatase
HEC60_18665	COG3118	belongs to the thioredoxin family
HEC60_18675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HEC60_18680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HEC60_18685	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HEC60_18690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HEC60_18695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HEC60_18700	COG0456	acetyltransferase
HEC60_18705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HEC60_18710	COG2244	polysaccharide biosynthetic process
HEC60_18755	COG3071	HemY protein
HEC60_18760	COG2959	enzyme of heme biosynthesis
HEC60_18770	COG0181	hydroxymethylbilane synthase activity
HEC60_18775	COG3072	Adenylate cyclase
HEC60_18805	COG1011	Hydrolase
HEC60_18810	COG0210	DNA helicase
HEC60_18840	COG1280	lysine exporter protein (LysE YggA)
HEC60_18845	COG1280	lysine exporter protein (LysE YggA)
HEC60_18850	COG2267	carboxylic ester hydrolase activity
HEC60_18855	COG0561	phosphatase activity
HEC60_18860	COG0697	spore germination
HEC60_18865	COG0583	DNA-binding transcription factor activity
HEC60_18885	COG0412	Dienelactone hydrolase
HEC60_18910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HEC60_18925	COG0805	protein transport
HEC60_18965	COG1739	Uncharacterized protein family UPF0029
HEC60_18975	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HEC60_19000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HEC60_19010	COG1072	(Pantothenic acid kinase))
HEC60_19045	COG0250	Participates in transcription elongation, termination and antitermination
HEC60_19090	COG3706	GGDEF domain
HEC60_19105	COG2104	thiamine diphosphate biosynthetic process
HEC60_19110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HEC60_19125	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HEC60_19160	COG0151	Belongs to the GarS family
HEC60_19205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HEC60_19235	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HEC60_19245	COG1187	pseudouridine synthase activity
HEC60_19255	COG0527	aspartate kinase activity
HEC60_19280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC60_19290	COG3223	Belongs to the PsiE family
HEC60_19305	COG2182	Extracellular solute-binding protein
HEC60_19325	COG3161	chorismate lyase activity
HEC60_19340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HEC60_19350	COG0534	Mate efflux family protein
HEC60_19355	COG0735	belongs to the Fur family
HEC60_19370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HEC60_19385	COG0305	Participates in initiation and elongation during chromosome replication
HEC60_19395	COG1448	Aminotransferase
HEC60_19400	COG3700	Belongs to the class B bacterial acid phosphatase family
HEC60_19405	COG2315	Protein conserved in bacteria
HEC60_19420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HEC60_19425	COG0629	single-stranded DNA binding
HEC60_19440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC60_19450	COG0789	Transcriptional regulator
HEC60_19460	COG2252	PERMEase
HEC60_19465	COG0025	NhaP-type Na H and K H
HEC60_19470	COG0583	DNA-binding transcription factor activity
HEC60_19475	COG1380	Effector of murein hydrolase LrgA
HEC60_19480	COG1346	cytolysis
HEC60_19485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HEC60_19490	COG3162	membrane
HEC60_19495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HEC60_19500	COG1301	dicarboxylic acid transport
HEC60_19505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HEC60_19525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HEC60_19530	COG0456	acetyltransferase
HEC60_19535	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HEC60_19540	COG3454	Phosphonate metabolism
HEC60_19545	COG4778	phosphonate C-P lyase system protein PhnL
HEC60_19550	COG4107	phosphonate C-P lyase system protein PhnK
HEC60_19555	COG3627	carbon phosphorus lyase activity
HEC60_19560	COG3626	phosphonate metabolism
HEC60_19565	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HEC60_19570	COG3624	Phosphonate C-P lyase system protein PhnG
HEC60_19575	COG2188	Transcriptional regulator
HEC60_19580	COG3639	organic phosphonate transmembrane transporter activity
HEC60_19585	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HEC60_19590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HEC60_19595	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HEC60_19600	COG2824	Alkylphosphonate utilization operon protein PhnA
HEC60_19605	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HEC60_19620	COG2200	EAL domain
HEC60_19630	COG0583	DNA-binding transcription factor activity
HEC60_19635	COG2207	Transcriptional regulator
HEC60_19640	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HEC60_19675	COG1309	transcriptional regulator
HEC60_19690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HEC60_19695	COG1027	Aspartate ammonia-lyase
HEC60_19700	COG3030	protein affecting phage T7 exclusion by the F plasmid
HEC60_19710	COG0459	protein refolding
HEC60_19725	COG1509	lysine 2,3-aminomutase activity
HEC60_19745	COG2076	Multidrug Resistance protein
HEC60_19765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HEC60_19770	COG1053	succinate dehydrogenase
HEC60_19775	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HEC60_19780	COG1511	domain protein
HEC60_19780	COG3264	Mechanosensitive ion channel
HEC60_19795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HEC60_19815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HEC60_19820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HEC60_19820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HEC60_19825	COG0802	atpase or kinase
HEC60_19840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HEC60_19845	COG1923	regulation of RNA biosynthetic process
HEC60_19850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HEC60_19855	COG0330	HflC and HflK could
HEC60_19860	COG0330	HflC and HflK could
HEC60_19865	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HEC60_19880	COG0557	exoribonuclease II activity
HEC60_19885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HEC60_19890	COG0477	Major facilitator Superfamily
HEC60_19895	COG1960	acyl-CoA dehydrogenase activity
HEC60_19905	COG3650	response to hydrogen peroxide
HEC60_19910	COG1073	alpha beta
HEC60_19965	COG2965	DNA replication, synthesis of RNA primer
HEC60_19970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HEC60_19975	COG0359	binds to the 23S rRNA
HEC60_19985	COG3061	Opacity-associated protein A
HEC60_19990	COG0545	Peptidyl-prolyl cis-trans isomerase
HEC60_19995	COG1113	amino acid transport
HEC60_20005	COG0840	transmembrane signaling receptor activity
HEC60_20010	COG0697	spore germination
HEC60_20020	COG0702	epimerase
HEC60_20025	COG1733	regulation of RNA biosynthetic process
HEC60_20035	COG1218	3'(2'),5'-bisphosphate nucleotidase
HEC60_20040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HEC60_20050	COG1253	flavin adenine dinucleotide binding
HEC60_20060	COG0729	surface antigen
HEC60_20065	COG2911	Protein conserved in bacteria
HEC60_20070	COG2105	PFAM AIG2 family protein
HEC60_20080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HEC60_20085	COG1879	ABC-type sugar transport system periplasmic component
HEC60_20090	COG1129	ABC transporter
HEC60_20095	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_20100	COG1172	Belongs to the binding-protein-dependent transport system permease family
HEC60_20105	COG0840	transmembrane signaling receptor activity
HEC60_20115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HEC60_20125	COG0312	modulator of DNA gyrase
HEC60_20130	COG3783	Cytochrome b(562)
HEC60_20160	COG3964	amidohydrolase
HEC60_20180	COG3711	transcriptional antiterminator
HEC60_20180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_20190	COG0602	queuosine metabolic process
HEC60_20205	COG2249	NAD(P)H dehydrogenase (quinone) activity
HEC60_20220	COG1486	melibiose metabolic process
HEC60_20225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC60_20230	COG0366	Alpha amylase catalytic
HEC60_20235	COG1263	PTS System
HEC60_20235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_20240	COG1609	Transcriptional regulator
HEC60_20275	COG1438	arginine binding
HEC60_20295	COG2235	arginine
HEC60_20300	COG2731	YhcH YjgK YiaL family protein
HEC60_20330	COG2927	DNA polymerase III (CHI subunit)
HEC60_20340	COG0795	lipopolysaccharide-transporting ATPase activity
HEC60_20345	COG0795	lipopolysaccharide-transporting ATPase activity
HEC60_20350	COG0433	COG0433 Predicted ATPase
HEC60_20360	COG1064	alcohol dehydrogenase
HEC60_20380	COG0582	viral genome integration into host DNA
HEC60_20395	COG1401	restriction endodeoxyribonuclease activity
HEC60_20405	COG0732	type I restriction modification DNA specificity domain
HEC60_20410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HEC60_20485	COG3596	GTP binding
HEC60_20515	COG2003	Belongs to the UPF0758 family
HEC60_20540	COG3423	Transcriptional regulator
HEC60_20570	COG0531	amino acid
HEC60_20585	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_20590	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HEC60_20600	COG2850	peptidyl-arginine hydroxylation
HEC60_20610	COG2233	PERMEase
HEC60_20620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC60_20625	COG2252	PERMEase
HEC60_20630	COG0402	S-adenosylhomocysteine deaminase activity
HEC60_20635	COG2233	PERMEase
HEC60_20640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEC60_20640	COG2080	2 iron, 2 sulfur cluster binding
HEC60_20645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEC60_20650	COG0402	S-adenosylhomocysteine deaminase activity
HEC60_20655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HEC60_20655	COG0493	'glutamate synthase
HEC60_20660	COG2068	MobA-Related Protein
HEC60_20665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEC60_20670	COG3608	succinylglutamate desuccinylase aspartoacylase
HEC60_20670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HEC60_20675	COG0549	Belongs to the carbamate kinase family
HEC60_20685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HEC60_20690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HEC60_20695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HEC60_20705	COG2080	2 iron, 2 sulfur cluster binding
HEC60_20710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HEC60_20715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HEC60_20730	COG3716	PTS system mannose fructose sorbose family IID component
HEC60_20735	COG3715	PTS system
HEC60_20740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_20740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_20755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HEC60_20760	COG5457	Domain of unknown function (DUF1127)
HEC60_20780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HEC60_20785	COG2368	4-hydroxyphenylacetate
HEC60_20805	COG3971	2-oxopent-4-enoate hydratase activity
HEC60_20815	COG3384	dioxygenase
HEC60_20820	COG1012	belongs to the aldehyde dehydrogenase family
HEC60_20825	COG0179	Fumarylacetoacetate (FAA) hydrolase
HEC60_20830	COG1846	Transcriptional regulator
HEC60_20840	COG1924	4 iron, 4 sulfur cluster binding
HEC60_20845	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HEC60_20855	COG0583	DNA-binding transcription factor activity
HEC60_20860	COG4139	cobalamin transport
HEC60_20865	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HEC60_20880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HEC60_20890	COG4865	methylaspartate mutase activity
HEC60_20895	COG3799	methylaspartate ammonia-lyase activity
HEC60_20910	COG1301	dicarboxylic acid transport
HEC60_20930	COG2814	Major facilitator Superfamily
HEC60_20935	COG2733	membrane
HEC60_20945	COG0523	cobalamin synthesis protein
HEC60_20950	COG2879	small protein
HEC60_20955	COG1966	Carbon starvation protein
HEC60_20980	COG0840	transmembrane signaling receptor activity
HEC60_20990	COG1214	PFAM Peptidase M22, glycoprotease
HEC60_20990	COG0456	acetyltransferase
HEC60_21005	COG1484	DNA-dependent DNA replication
HEC60_21015	COG1764	response to oxidative stress
HEC60_21025	COG2966	Psort location CytoplasmicMembrane, score
HEC60_21035	COG2197	response regulator
HEC60_21040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC60_21045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HEC60_21050	COG4114	ferric iron reductase
HEC60_21055	COG3706	GGDEF domain
HEC60_21085	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HEC60_21090	COG0456	acetyltransferase
HEC60_21095	COG1011	Hydrolase
HEC60_21105	COG2823	Periplasmic or secreted lipoprotein
HEC60_21115	COG4667	esterase of the alpha-beta hydrolase superfamily
HEC60_21120	COG0084	hydrolase, TatD family'
HEC60_21125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HEC60_21130	COG1328	CTP reductase activity
HEC60_21150	COG0813	purine-nucleoside phosphorylase activity
HEC60_21160	COG3726	membrane protein affecting hemolysin expression
HEC60_21165	COG0560	Phosphoserine phosphatase
HEC60_21180	COG0488	(ABC) transporter
HEC60_21185	COG0741	lytic transglycosylase activity
HEC60_21195	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HEC60_21205	COG3708	Transcriptional regulator
HEC60_21205	COG2207	Transcriptional regulator
HEC60_21210	COG3045	CreA protein
HEC60_21215	COG0745	RESPONSE REGULATOR receiver
HEC60_21220	COG2205	protein histidine kinase activity
HEC60_21225	COG4452	Inner membrane protein CreD
HEC60_21230	COG0745	RESPONSE REGULATOR receiver
HEC60_21240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HEC60_21250	COG0527	aspartate kinase activity
HEC60_21250	COG0460	homoserine dehydrogenase
HEC60_21260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HEC60_21270	COG3022	response to hydroperoxide
HEC60_21275	COG1115	amino acid carrier protein
HEC60_21280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HEC60_21285	COG0521	Mo-molybdopterin cofactor biosynthetic process
HEC60_21295	COG1584	GPR1 FUN34 yaaH family protein
HEC60_21325	COG0583	DNA-binding transcription factor activity
HEC60_21330	COG0268	Binds directly to 16S ribosomal RNA
HEC60_21335	COG0196	riboflavin kinase activity
HEC60_21350	COG1047	Peptidyl-prolyl cis-trans
HEC60_21365	COG2140	Oxalate decarboxylase
HEC60_21375	COG3716	PTS system mannose fructose sorbose family IID component
HEC60_21380	COG3715	PTS system
HEC60_21385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_21385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_21400	COG1609	Transcriptional regulator
HEC60_21410	COG0505	Belongs to the CarA family
HEC60_21470	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HEC60_21475	COG0564	pseudouridine synthase activity
HEC60_21485	COG0417	DNA replication proofreading
HEC60_21490	COG0235	Class ii aldolase
HEC60_21515	COG0586	Pfam SNARE associated Golgi protein
HEC60_21525	COG1178	ABC-type Fe3 transport system permease component
HEC60_21540	COG2814	Major facilitator Superfamily
HEC60_21545	COG0066	3-isopropylmalate dehydratase activity
HEC60_21575	COG0028	Belongs to the TPP enzyme family
HEC60_21605	COG0768	penicillin binding
HEC60_21610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HEC60_21615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HEC60_21625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HEC60_21630	COG0772	Belongs to the SEDS family
HEC60_21655	COG0849	cell division
HEC60_21660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HEC60_21680	COG0494	nUDIX hydrolase
HEC60_21705	COG1459	type II secretion system
HEC60_21710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC60_21715	COG4969	Belongs to the N-Me-Phe pilin family
HEC60_21730	COG3725	Membrane protein required for beta-lactamase induction
HEC60_21740	COG2211	Major facilitator Superfamily
HEC60_21745	COG1113	amino acid transport
HEC60_21750	COG2186	Transcriptional regulator
HEC60_21755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HEC60_21760	COG0508	dehydrogenase complex catalyzes the overall conversion of
HEC60_21765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HEC60_21780	COG3064	Membrane
HEC60_21810	COG2132	Multicopper oxidase
HEC60_21815	COG4993	Dehydrogenase
HEC60_21820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HEC60_21825	COG0288	reversible hydration of carbon dioxide
HEC60_21830	COG1131	(ABC) transporter
HEC60_21835	COG0842	Transport permease protein
HEC60_21840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HEC60_21845	COG0726	polysaccharide deacetylase
HEC60_21850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HEC60_21865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEC60_21870	COG0617	tRNA 3'-terminal CCA addition
HEC60_21880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HEC60_21890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HEC60_21895	COG1643	Atp-dependent helicase
HEC60_21900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HEC60_21905	COG4774	siderophore transport
HEC60_21910	COG1120	ATPase activity
HEC60_21915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HEC60_21925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HEC60_21940	COG2860	membrane
HEC60_21960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HEC60_21990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HEC60_22005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HEC60_22015	COG0575	Belongs to the CDS family
HEC60_22025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HEC60_22030	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HEC60_22035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEC60_22040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HEC60_22045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEC60_22060	COG0587	DNA-directed DNA polymerase activity
HEC60_22075	COG0346	lactoylglutathione lyase activity
HEC60_22080	COG0037	tRNA processing
HEC60_22085	COG4568	rho-dependent transcription termination
HEC60_22095	COG4681	YaeQ
HEC60_22100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HEC60_22105	COG3015	lipoprotein NlpE involved in copper resistance
HEC60_22115	COG1720	tRNA m6t6A37 methyltransferase activity
HEC60_22125	COG1464	Belongs to the NlpA lipoprotein family
HEC60_22130	COG2011	ABC-type metal ion transport system permease component
HEC60_22135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HEC60_22140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HEC60_22180	COG0583	DNA-binding transcription factor activity
HEC60_22185	COG2814	Major facilitator Superfamily
HEC60_22190	COG3021	interspecies interaction between organisms
HEC60_22195	COG2226	methyltransferase
HEC60_22200	COG0741	lytic transglycosylase activity
HEC60_22200	COG1388	LysM domain
HEC60_22210	COG2226	methyltransferase
HEC60_22215	COG0328	RNA-DNA hybrid ribonuclease activity
HEC60_22240	COG1566	PFAM secretion protein HlyD family protein
HEC60_22255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HEC60_22270	COG0121	glutamine amidotransferase
HEC60_22275	COG3034	peptidoglycan biosynthetic process
HEC60_22290	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HEC60_22295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HEC60_22310	COG2991	Protein conserved in bacteria
HEC60_22330	COG2195	Cleaves the N-terminal amino acid of tripeptides
HEC60_22335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HEC60_22350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC60_22355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HEC60_22370	COG0582	viral genome integration into host DNA
HEC60_22425	COG2223	nitrite transmembrane transporter activity
HEC60_22455	COG2431	L-lysine efflux transmembrane transporter activity
HEC60_22490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HEC60_22505	COG3443	Belongs to the bacterial solute-binding protein 9 family
HEC60_22545	COG0513	Belongs to the DEAD box helicase family
HEC60_22555	COG2091	lysine biosynthetic process via aminoadipic acid
HEC60_22560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC60_22565	COG1028	Short-chain dehydrogenase reductase Sdr
HEC60_22575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HEC60_22600	COG1216	Glycosyl transferase, family 2
HEC60_22620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HEC60_22630	COG0204	Acyl-transferase
HEC60_22650	COG1566	PFAM secretion protein HlyD family protein
HEC60_22660	COG4521	taurine ABC transporter
HEC60_22665	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HEC60_22670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HEC60_22675	COG2175	clavaminate synthase activity
HEC60_22685	COG0113	porphobilinogen synthase activity
HEC60_22695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HEC60_22700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HEC60_22705	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HEC60_22740	COG1785	Belongs to the alkaline phosphatase family
HEC60_22750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HEC60_22760	COG3416	Protein conserved in bacteria
HEC60_22765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HEC60_22770	COG4126	flavin adenine dinucleotide binding
HEC60_22775	COG3123	guanosine phosphorylase activity
HEC60_22785	COG1940	carbohydrate kinase activity
HEC60_22790	COG0419	ATPase involved in DNA repair
HEC60_22795	COG0420	3'-5' exonuclease activity
HEC60_22805	COG5002	protein histidine kinase activity
HEC60_22820	COG0366	Alpha amylase catalytic
HEC60_22825	COG0583	DNA-binding transcription factor activity
HEC60_22830	COG1335	isochorismatase
HEC60_22840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HEC60_22845	COG0450	alkyl hydroperoxide reductase
HEC60_22850	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HEC60_22855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HEC60_22865	COG1862	Preprotein translocase
HEC60_22870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEC60_22875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HEC60_22890	COG3248	Nucleoside-binding outer membrane protein
HEC60_22895	COG4238	major outer membrane lipoprotein
HEC60_22905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC60_22905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HEC60_22915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HEC60_22920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HEC60_22925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HEC60_22930	COG0667	Aldo Keto reductase
HEC60_22940	COG0142	geranyltranstransferase activity
HEC60_22955	COG0693	protein deglycase activity
HEC60_22960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HEC60_22970	COG2814	Major facilitator Superfamily
HEC60_22980	COG0109	protoheme IX farnesyltransferase activity
HEC60_22985	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HEC60_22990	COG1845	cytochrome c oxidase, subunit III
HEC60_22995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HEC60_23000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HEC60_23005	COG2223	nitrite transmembrane transporter activity
HEC60_23010	COG3056	Lipoprotein
HEC60_23015	COG0271	Belongs to the BolA IbaG family
HEC60_23035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HEC60_23040	COG0776	regulation of translation
HEC60_23045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HEC60_23050	COG1555	photosystem II stabilization
HEC60_23055	COG0824	Thioesterase
HEC60_23065	COG1598	PFAM Uncharacterised protein family UPF0150
HEC60_23075	COG4533	DNA binding
HEC60_23080	COG0561	phosphatase activity
HEC60_23085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HEC60_23090	COG1522	sequence-specific DNA binding
HEC60_23095	COG1132	(ABC) transporter
HEC60_23100	COG1132	(ABC) transporter
HEC60_23105	COG0347	Belongs to the P(II) protein family
HEC60_23110	COG0004	ammonium transporteR
HEC60_23115	COG1946	Acyl-CoA thioesterase
HEC60_23120	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HEC60_23125	COG3695	enzyme binding
HEC60_23265	COG2364	Membrane
HEC60_23270	COG3250	beta-galactosidase activity
HEC60_23275	COG5507	3-demethylubiquinone-9 3-methyltransferase
HEC60_23280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HEC60_23285	COG2011	ABC-type metal ion transport system permease component
HEC60_23310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HEC60_23330	COG0110	maltose O-acetyltransferase activity
HEC60_23345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HEC60_23350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HEC60_23355	COG1309	transcriptional regulator
HEC60_23360	COG3264	Mechanosensitive ion channel
HEC60_23360	COG1196	nuclear chromosome segregation
HEC60_23370	COG3923	Primosomal replication protein n
HEC60_23375	COG2832	Protein of unknown function (DUF454)
HEC60_23390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HEC60_23415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HEC60_23420	COG4651	solute:proton antiporter activity
HEC60_23420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HEC60_23425	COG2223	nitrite transmembrane transporter activity
HEC60_23435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HEC60_23440	COG3735	TraB family
HEC60_23455	COG1585	Membrane protein implicated in regulation of membrane protease activity
HEC60_23460	COG0330	HflC and HflK could
HEC60_23465	COG4619	ABC transporter
HEC60_23470	COG0390	transport system, permease component
HEC60_23475	COG3118	belongs to the thioredoxin family
HEC60_23480	COG0300	oxidoreductase activity
HEC60_23485	COG2755	lipolytic protein G-D-S-L family
HEC60_23490	COG4181	ATPase activity
HEC60_23495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HEC60_23515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HEC60_23525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HEC60_23530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HEC60_23535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HEC60_23540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HEC60_23550	COG1609	Transcriptional regulator
HEC60_23555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HEC60_23555	COG1263	PTS System
HEC60_23555	COG2190	(PTS) system
HEC60_23560	COG2501	S4 domain
HEC60_23570	COG3539	Fimbrial protein
HEC60_23615	COG0582	viral genome integration into host DNA
HEC60_23670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HEC60_23740	COG0305	Participates in initiation and elongation during chromosome replication
HEC60_23845	COG1783	phage Terminase large subunit
HEC60_23955	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HEC60_23965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HEC60_23975	COG1982	Orn Lys Arg decarboxylase major
HEC60_23980	COG0531	amino acid
HEC60_24060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HEC60_24175	COG0697	spore germination
HEC60_24190	COG0768	penicillin binding
HEC60_24250	COG2135	peptidase activity
HEC60_24315	COG0489	protein tyrosine kinase activity
HEC60_24580	COG2805	Type II/IV secretion system protein
HEC60_24630	COG0741	lytic transglycosylase activity
HEC60_24645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HEC60_24735	COG2207	Transcriptional regulator
HEC60_24745	COG1484	DNA-dependent DNA replication
HEC60_24780	COG3550	peptidyl-serine autophosphorylation
HEC60_24895	COG1475	DNA binding
HEC60_24900	COG3969	phosphoadenosine phosphosulfate
HEC60_24975	COG2801	Transposase and inactivated derivatives
HEC60_25055	COG2207	Transcriptional regulator
HEC60_25095	COG2963	transposase activity
HEC60_25240	COG4584	PFAM Integrase catalytic