locus-tag	class	description
LOKVESSMR4R_00001	COG4962	Type ii secretion system protein e
LOKVESSMR4R_00004	COG3451	type IV secretory pathway VirB4
LOKVESSMR4R_00005	COG5314	conjugation
LOKVESSMR4R_00006	COG3846	protein secretion by the type IV secretion system
LOKVESSMR4R_00009	COG2948	multi-organism process
LOKVESSMR4R_00046	COG0776	regulation of translation
LOKVESSMR4R_00056	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00057	COG0517	IMP dehydrogenase activity
LOKVESSMR4R_00058	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LOKVESSMR4R_00060	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LOKVESSMR4R_00061	COG1268	BioY protein
LOKVESSMR4R_00063	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LOKVESSMR4R_00064	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LOKVESSMR4R_00067	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LOKVESSMR4R_00070	COG2022	thiamine diphosphate biosynthetic process
LOKVESSMR4R_00073	COG0351	phosphomethylpyrimidine kinase
LOKVESSMR4R_00075	COG0778	Nitroreductase
LOKVESSMR4R_00076	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LOKVESSMR4R_00077	COG0602	queuosine metabolic process
LOKVESSMR4R_00078	COG0720	synthase
LOKVESSMR4R_00079	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LOKVESSMR4R_00080	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LOKVESSMR4R_00086	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LOKVESSMR4R_00087	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00089	COG2132	Multicopper oxidase
LOKVESSMR4R_00093	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKVESSMR4R_00099	COG2801	Transposase and inactivated derivatives
LOKVESSMR4R_00100	COG2963	transposase activity
LOKVESSMR4R_00102	COG1937	Protein conserved in bacteria
LOKVESSMR4R_00106	COG3547	Transposase (IS116 IS110 IS902 family)
LOKVESSMR4R_00112	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00113	COG0582	viral genome integration into host DNA
LOKVESSMR4R_00114	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00121	COG0789	Transcriptional regulator
LOKVESSMR4R_00126	COG1162	GTPase activity
LOKVESSMR4R_00137	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOKVESSMR4R_00140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOKVESSMR4R_00141	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LOKVESSMR4R_00142	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LOKVESSMR4R_00143	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LOKVESSMR4R_00144	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LOKVESSMR4R_00147	COG0596	Alpha beta hydrolase
LOKVESSMR4R_00149	COG2983	Belongs to the UPF0260 family
LOKVESSMR4R_00150	COG0196	riboflavin kinase activity
LOKVESSMR4R_00151	COG2030	dehydratase
LOKVESSMR4R_00153	COG1227	inorganic diphosphatase activity
LOKVESSMR4R_00157	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00158	COG3850	Histidine kinase
LOKVESSMR4R_00158	COG5002	protein histidine kinase activity
LOKVESSMR4R_00160	COG3768	UPF0283 membrane protein
LOKVESSMR4R_00161	COG3106	COG3106 Predicted ATPase
LOKVESSMR4R_00162	COG0101	tRNA pseudouridine synthase activity
LOKVESSMR4R_00163	COG0729	surface antigen
LOKVESSMR4R_00167	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LOKVESSMR4R_00168	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LOKVESSMR4R_00169	COG3698	Phosphodiester glycosidase
LOKVESSMR4R_00172	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKVESSMR4R_00173	COG2835	tetraacyldisaccharide 4'-kinase activity
LOKVESSMR4R_00175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LOKVESSMR4R_00176	COG0154	amidase activity
LOKVESSMR4R_00178	COG1674	ftsk spoiiie
LOKVESSMR4R_00180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LOKVESSMR4R_00183	COG0328	RNA-DNA hybrid ribonuclease activity
LOKVESSMR4R_00185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LOKVESSMR4R_00186	COG0534	Mate efflux family protein
LOKVESSMR4R_00188	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LOKVESSMR4R_00189	COG1758	RNA polymerase activity
LOKVESSMR4R_00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LOKVESSMR4R_00192	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LOKVESSMR4R_00193	COG0736	holo-[acyl-carrier-protein] synthase activity
LOKVESSMR4R_00194	COG0681	Belongs to the peptidase S26 family
LOKVESSMR4R_00195	COG0571	ribonuclease III activity
LOKVESSMR4R_00196	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LOKVESSMR4R_00198	COG1381	Involved in DNA repair and RecF pathway recombination
LOKVESSMR4R_00202	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LOKVESSMR4R_00203	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00204	COG2205	protein histidine kinase activity
LOKVESSMR4R_00206	COG1660	Displays ATPase and GTPase activities
LOKVESSMR4R_00208	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LOKVESSMR4R_00209	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_00213	COG2096	Adenosyltransferase
LOKVESSMR4R_00215	COG0300	oxidoreductase activity
LOKVESSMR4R_00216	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LOKVESSMR4R_00217	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LOKVESSMR4R_00221	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LOKVESSMR4R_00222	COG0250	Participates in transcription elongation, termination and antitermination
LOKVESSMR4R_00223	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LOKVESSMR4R_00224	COG0081	regulation of translation
LOKVESSMR4R_00226	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LOKVESSMR4R_00227	COG0222	ribosome binding
LOKVESSMR4R_00228	COG0085	RNA polymerase activity
LOKVESSMR4R_00229	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LOKVESSMR4R_00232	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LOKVESSMR4R_00233	COG0049	tRNA binding
LOKVESSMR4R_00234	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LOKVESSMR4R_00235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LOKVESSMR4R_00237	COG0051	transcription antitermination factor activity, RNA binding
LOKVESSMR4R_00238	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LOKVESSMR4R_00239	COG0088	Forms part of the polypeptide exit tunnel
LOKVESSMR4R_00240	COG0089	rRNA binding
LOKVESSMR4R_00242	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LOKVESSMR4R_00243	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LOKVESSMR4R_00244	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LOKVESSMR4R_00245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LOKVESSMR4R_00246	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LOKVESSMR4R_00249	COG0255	Belongs to the universal ribosomal protein uL29 family
LOKVESSMR4R_00250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LOKVESSMR4R_00251	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LOKVESSMR4R_00252	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LOKVESSMR4R_00253	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LOKVESSMR4R_00254	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LOKVESSMR4R_00255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LOKVESSMR4R_00256	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LOKVESSMR4R_00257	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LOKVESSMR4R_00258	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LOKVESSMR4R_00259	COG1841	ribosomal large subunit assembly
LOKVESSMR4R_00260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKVESSMR4R_00261	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LOKVESSMR4R_00263	COG0560	Phosphoserine phosphatase
LOKVESSMR4R_00263	COG3830	Belongs to the UPF0237 family
LOKVESSMR4R_00266	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00268	COG1120	ATPase activity
LOKVESSMR4R_00270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOKVESSMR4R_00271	COG3604	Transcriptional regulator
LOKVESSMR4R_00272	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_00272	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKVESSMR4R_00273	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_00274	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_00275	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LOKVESSMR4R_00280	COG0765	amino acid transport
LOKVESSMR4R_00281	COG0765	amino acid transport
LOKVESSMR4R_00282	COG4598	ABC transporter
LOKVESSMR4R_00285	COG1051	belongs to the nudix hydrolase family
LOKVESSMR4R_00286	COG0557	exoribonuclease II activity
LOKVESSMR4R_00288	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOKVESSMR4R_00291	COG0469	pyruvate kinase activity
LOKVESSMR4R_00292	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LOKVESSMR4R_00293	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LOKVESSMR4R_00294	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LOKVESSMR4R_00296	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_00297	COG0431	NADPH-dependent FMN reductase
LOKVESSMR4R_00299	COG0405	Gamma-glutamyltransferase
LOKVESSMR4R_00302	COG1396	sequence-specific DNA binding
LOKVESSMR4R_00308	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LOKVESSMR4R_00309	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
LOKVESSMR4R_00310	COG1522	sequence-specific DNA binding
LOKVESSMR4R_00311	COG0686	Belongs to the AlaDH PNT family
LOKVESSMR4R_00312	COG1970	mechanosensitive ion channel activity
LOKVESSMR4R_00315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKVESSMR4R_00315	COG0072	phenylalanine-tRNA ligase activity
LOKVESSMR4R_00328	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LOKVESSMR4R_00332	COG0435	Glutathione S-transferase
LOKVESSMR4R_00340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LOKVESSMR4R_00341	COG0242	peptide deformylase activity
LOKVESSMR4R_00342	COG0242	peptide deformylase activity
LOKVESSMR4R_00343	COG0242	peptide deformylase activity
LOKVESSMR4R_00344	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LOKVESSMR4R_00346	COG1376	ErfK ybiS ycfS ynhG family protein
LOKVESSMR4R_00351	COG1012	belongs to the aldehyde dehydrogenase family
LOKVESSMR4R_00356	COG3195	allantoin biosynthetic process
LOKVESSMR4R_00356	COG3648	Uricase
LOKVESSMR4R_00357	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LOKVESSMR4R_00362	COG1414	Transcriptional regulator
LOKVESSMR4R_00363	COG0798	PFAM Bile acid sodium symporter
LOKVESSMR4R_00365	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_00366	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_00368	COG0410	ABC transporter
LOKVESSMR4R_00371	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_00372	COG0601	transmembrane transport
LOKVESSMR4R_00373	COG4166	transmembrane transport
LOKVESSMR4R_00375	COG2197	response regulator
LOKVESSMR4R_00385	COG0006	proline dipeptidase activity
LOKVESSMR4R_00387	COG1522	sequence-specific DNA binding
LOKVESSMR4R_00388	COG1802	Transcriptional regulator
LOKVESSMR4R_00390	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_00392	COG0747	negative chemotaxis
LOKVESSMR4R_00396	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LOKVESSMR4R_00398	COG2226	methyltransferase
LOKVESSMR4R_00399	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LOKVESSMR4R_00408	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LOKVESSMR4R_00410	COG4778	phosphonate C-P lyase system protein PhnL
LOKVESSMR4R_00411	COG4107	phosphonate C-P lyase system protein PhnK
LOKVESSMR4R_00412	COG3627	carbon phosphorus lyase activity
LOKVESSMR4R_00416	COG2186	Transcriptional regulator
LOKVESSMR4R_00418	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LOKVESSMR4R_00418	COG0519	Catalyzes the synthesis of GMP from XMP
LOKVESSMR4R_00420	COG0174	glutamine synthetase
LOKVESSMR4R_00423	COG1234	tRNA 3'-trailer cleavage
LOKVESSMR4R_00424	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKVESSMR4R_00429	COG1012	belongs to the aldehyde dehydrogenase family
LOKVESSMR4R_00430	COG5441	Belongs to the UPF0261 family
LOKVESSMR4R_00432	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LOKVESSMR4R_00434	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKVESSMR4R_00440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LOKVESSMR4R_00448	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOKVESSMR4R_00451	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LOKVESSMR4R_00452	COG5310	Homospermidine synthase
LOKVESSMR4R_00454	COG0287	Prephenate dehydrogenase
LOKVESSMR4R_00455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LOKVESSMR4R_00456	COG1183	phosphatidylcholine synthase activity
LOKVESSMR4R_00459	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LOKVESSMR4R_00461	COG1435	thymidine kinase activity
LOKVESSMR4R_00462	COG0431	NADPH-dependent FMN reductase
LOKVESSMR4R_00464	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LOKVESSMR4R_00465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LOKVESSMR4R_00466	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00475	COG1272	protein, Hemolysin III
LOKVESSMR4R_00478	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKVESSMR4R_00480	COG0842	Transport permease protein
LOKVESSMR4R_00482	COG0697	spore germination
LOKVESSMR4R_00483	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LOKVESSMR4R_00484	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LOKVESSMR4R_00485	COG1643	Atp-dependent helicase
LOKVESSMR4R_00486	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LOKVESSMR4R_00487	COG1703	isobutyryl-CoA mutase activity
LOKVESSMR4R_00489	COG0481	GTPase activity
LOKVESSMR4R_00493	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOKVESSMR4R_00495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_00498	COG0280	phosphate acetyltransferase
LOKVESSMR4R_00498	COG0281	malic enzyme
LOKVESSMR4R_00502	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LOKVESSMR4R_00503	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LOKVESSMR4R_00504	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LOKVESSMR4R_00506	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_00508	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_00508	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_00509	COG0183	Belongs to the thiolase family
LOKVESSMR4R_00510	COG0625	glutathione transferase activity
LOKVESSMR4R_00511	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_00512	COG0789	Transcriptional regulator
LOKVESSMR4R_00516	COG0534	Mate efflux family protein
LOKVESSMR4R_00519	COG0737	Belongs to the 5'-nucleotidase family
LOKVESSMR4R_00521	COG1132	(ABC) transporter
LOKVESSMR4R_00522	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_00524	COG2201	protein-glutamate methylesterase activity
LOKVESSMR4R_00526	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00527	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LOKVESSMR4R_00530	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00533	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LOKVESSMR4R_00533	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LOKVESSMR4R_00536	COG1982	Orn Lys Arg decarboxylase major
LOKVESSMR4R_00537	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKVESSMR4R_00538	COG0006	proline dipeptidase activity
LOKVESSMR4R_00539	COG3608	succinylglutamate desuccinylase aspartoacylase
LOKVESSMR4R_00543	COG2094	Belongs to the DNA glycosylase MPG family
LOKVESSMR4R_00545	COG4681	YaeQ
LOKVESSMR4R_00547	COG1136	(ABC) transporter
LOKVESSMR4R_00556	COG3383	formate dehydrogenase (NAD+) activity
LOKVESSMR4R_00556	COG0243	molybdopterin cofactor binding
LOKVESSMR4R_00557	COG0437	4 iron, 4 sulfur cluster binding
LOKVESSMR4R_00558	COG2864	formate dehydrogenase
LOKVESSMR4R_00559	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_00564	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LOKVESSMR4R_00567	COG2084	Dehydrogenase
LOKVESSMR4R_00569	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKVESSMR4R_00570	COG0772	Belongs to the SEDS family
LOKVESSMR4R_00571	COG0768	penicillin binding
LOKVESSMR4R_00575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOKVESSMR4R_00576	COG4221	oxidoreductase activity
LOKVESSMR4R_00577	COG3046	protein related to deoxyribodipyrimidine photolyase
LOKVESSMR4R_00580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_00581	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKVESSMR4R_00583	COG4181	ATPase activity
LOKVESSMR4R_00585	COG1278	Cold shock
LOKVESSMR4R_00587	COG1278	Cold shock
LOKVESSMR4R_00588	COG0488	(ABC) transporter
LOKVESSMR4R_00590	COG1115	amino acid carrier protein
LOKVESSMR4R_00596	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LOKVESSMR4R_00598	COG0640	Transcriptional regulator
LOKVESSMR4R_00599	COG0587	DNA-directed DNA polymerase activity
LOKVESSMR4R_00600	COG2900	Belongs to the SlyX family
LOKVESSMR4R_00601	COG0124	histidyl-tRNA synthetase
LOKVESSMR4R_00602	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LOKVESSMR4R_00603	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LOKVESSMR4R_00605	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_00607	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOKVESSMR4R_00608	COG3718	enzyme involved in inositol metabolism
LOKVESSMR4R_00610	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_00612	COG1609	Transcriptional regulator
LOKVESSMR4R_00613	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_00615	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_00616	COG3962	Belongs to the TPP enzyme family
LOKVESSMR4R_00617	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_00620	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_00625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKVESSMR4R_00631	COG2010	Cytochrome c
LOKVESSMR4R_00632	COG1522	sequence-specific DNA binding
LOKVESSMR4R_00633	COG0492	ferredoxin-NADP+ reductase activity
LOKVESSMR4R_00634	COG0529	Catalyzes the synthesis of activated sulfate
LOKVESSMR4R_00634	COG2046	Belongs to the sulfate adenylyltransferase family
LOKVESSMR4R_00638	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LOKVESSMR4R_00639	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LOKVESSMR4R_00643	COG0459	protein refolding
LOKVESSMR4R_00648	COG0348	domain, Protein
LOKVESSMR4R_00650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKVESSMR4R_00655	COG0632	four-way junction helicase activity
LOKVESSMR4R_00656	COG2255	four-way junction helicase activity
LOKVESSMR4R_00659	COG0824	Thioesterase
LOKVESSMR4R_00661	COG0848	biopolymer transport protein
LOKVESSMR4R_00663	COG0823	Involved in the tonB-independent uptake of proteins
LOKVESSMR4R_00664	COG2885	chlorophyll binding
LOKVESSMR4R_00666	COG0037	tRNA processing
LOKVESSMR4R_00667	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKVESSMR4R_00669	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LOKVESSMR4R_00671	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LOKVESSMR4R_00673	COG1201	RNA secondary structure unwinding
LOKVESSMR4R_00683	COG4964	Belongs to the GSP D family
LOKVESSMR4R_00687	COG0741	lytic transglycosylase activity
LOKVESSMR4R_00688	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LOKVESSMR4R_00690	COG1754	DNA topoisomerase type I activity
LOKVESSMR4R_00690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LOKVESSMR4R_00691	COG0758	DNA mediated transformation
LOKVESSMR4R_00692	COG0312	modulator of DNA gyrase
LOKVESSMR4R_00696	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LOKVESSMR4R_00700	COG0612	Peptidase, M16
LOKVESSMR4R_00701	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LOKVESSMR4R_00702	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_00703	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LOKVESSMR4R_00704	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LOKVESSMR4R_00705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LOKVESSMR4R_00710	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_00713	COG0123	including yeast histone deacetylase and acetoin utilization protein
LOKVESSMR4R_00715	COG1519	Transferase
LOKVESSMR4R_00719	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00723	COG0678	peroxiredoxin activity
LOKVESSMR4R_00738	COG0737	Belongs to the 5'-nucleotidase family
LOKVESSMR4R_00740	COG0077	Prephenate dehydratase
LOKVESSMR4R_00740	COG1605	Chorismate mutase
LOKVESSMR4R_00743	COG4174	ABC transporter (Permease)
LOKVESSMR4R_00744	COG4239	(ABC) transporter, permease
LOKVESSMR4R_00745	COG4172	Belongs to the ABC transporter superfamily
LOKVESSMR4R_00746	COG1686	Belongs to the peptidase S11 family
LOKVESSMR4R_00747	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LOKVESSMR4R_00748	COG2813	Specifically methylates the guanine in position
LOKVESSMR4R_00749	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_00751	COG0408	coproporphyrinogen oxidase activity
LOKVESSMR4R_00752	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LOKVESSMR4R_00753	COG0181	hydroxymethylbilane synthase activity
LOKVESSMR4R_00756	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_00758	COG1294	oxidase, subunit
LOKVESSMR4R_00759	COG1271	oxidase subunit
LOKVESSMR4R_00760	COG2351	hydroxyisourate hydrolase activity
LOKVESSMR4R_00761	COG1454	alcohol dehydrogenase
LOKVESSMR4R_00762	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LOKVESSMR4R_00765	COG0395	ABC-type sugar transport system, permease component
LOKVESSMR4R_00768	COG3842	ATPase activity
LOKVESSMR4R_00770	COG1349	DNA-binding transcription factor activity
LOKVESSMR4R_00771	COG0501	Belongs to the peptidase M48B family
LOKVESSMR4R_00775	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKVESSMR4R_00776	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKVESSMR4R_00777	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKVESSMR4R_00777	COG1321	iron dependent repressor
LOKVESSMR4R_00778	COG1121	(ABC) transporter
LOKVESSMR4R_00779	COG0803	Belongs to the bacterial solute-binding protein 9 family
LOKVESSMR4R_00781	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKVESSMR4R_00784	COG2197	response regulator
LOKVESSMR4R_00790	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_00794	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LOKVESSMR4R_00801	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_00803	COG1609	Transcriptional regulator
LOKVESSMR4R_00805	COG4209	transmembrane transport
LOKVESSMR4R_00810	COG1522	sequence-specific DNA binding
LOKVESSMR4R_00811	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_00814	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_00825	COG2205	protein histidine kinase activity
LOKVESSMR4R_00832	COG2433	Pfam Transposase IS66
LOKVESSMR4R_00833	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_00834	COG2963	transposase activity
LOKVESSMR4R_00838	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_00853	COG0678	peroxiredoxin activity
LOKVESSMR4R_00858	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_00859	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LOKVESSMR4R_00864	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_00866	COG1129	ABC transporter
LOKVESSMR4R_00867	COG0410	ABC transporter
LOKVESSMR4R_00869	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_00871	COG4372	Transposase
LOKVESSMR4R_00872	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_00873	COG2963	transposase activity
LOKVESSMR4R_00877	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LOKVESSMR4R_00880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LOKVESSMR4R_00882	COG5328	Belongs to the UPF0262 family
LOKVESSMR4R_00885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LOKVESSMR4R_00889	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LOKVESSMR4R_00890	COG1943	Transposase
LOKVESSMR4R_00892	COG1278	Cold shock
LOKVESSMR4R_00893	COG1393	Belongs to the ArsC family
LOKVESSMR4R_00894	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LOKVESSMR4R_00899	COG3243	poly(R)-hydroxyalkanoic acid synthase
LOKVESSMR4R_00902	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_00903	COG0174	glutamine synthetase
LOKVESSMR4R_00904	COG0519	Catalyzes the synthesis of GMP from XMP
LOKVESSMR4R_00905	COG0174	glutamine synthetase
LOKVESSMR4R_00906	COG4160	amino acid transport
LOKVESSMR4R_00907	COG4215	(ABC) transporter
LOKVESSMR4R_00912	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LOKVESSMR4R_00914	COG0504	CTP synthase activity
LOKVESSMR4R_00916	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LOKVESSMR4R_00921	COG1760	l-serine dehydratase
LOKVESSMR4R_00922	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LOKVESSMR4R_00925	COG0330	HflC and HflK could
LOKVESSMR4R_00928	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LOKVESSMR4R_00929	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LOKVESSMR4R_00931	COG2873	o-acetylhomoserine
LOKVESSMR4R_00933	COG1285	pathogenesis
LOKVESSMR4R_00938	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LOKVESSMR4R_00939	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LOKVESSMR4R_00945	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_00950	COG3685	Protein conserved in bacteria
LOKVESSMR4R_00962	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LOKVESSMR4R_00962	COG1017	nitric oxide dioxygenase activity
LOKVESSMR4R_00972	COG1832	CoA-binding protein
LOKVESSMR4R_00973	COG0140	phosphoribosyl-ATP diphosphatase activity
LOKVESSMR4R_00974	COG0107	imidazoleglycerol-phosphate synthase activity
LOKVESSMR4R_00975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LOKVESSMR4R_00978	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LOKVESSMR4R_00979	COG0131	Imidazoleglycerol-phosphate dehydratase
LOKVESSMR4R_00983	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LOKVESSMR4R_00984	COG1304	FMN binding
LOKVESSMR4R_00985	COG0210	DNA helicase
LOKVESSMR4R_00987	COG1522	sequence-specific DNA binding
LOKVESSMR4R_00989	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_00991	COG2001	Belongs to the MraZ family
LOKVESSMR4R_00992	COG0275	rRNA processing
LOKVESSMR4R_00995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LOKVESSMR4R_00997	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LOKVESSMR4R_00998	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LOKVESSMR4R_00999	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_01000	COG2081	HI0933 family
LOKVESSMR4R_01003	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LOKVESSMR4R_01005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LOKVESSMR4R_01006	COG1181	Belongs to the D-alanine--D-alanine ligase family
LOKVESSMR4R_01007	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LOKVESSMR4R_01008	COG0849	cell division
LOKVESSMR4R_01009	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LOKVESSMR4R_01011	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOKVESSMR4R_01022	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOKVESSMR4R_01024	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LOKVESSMR4R_01026	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LOKVESSMR4R_01027	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LOKVESSMR4R_01027	COG2010	Cytochrome c
LOKVESSMR4R_01030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LOKVESSMR4R_01031	COG0752	glycyl-tRNA synthetase alpha subunit
LOKVESSMR4R_01034	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LOKVESSMR4R_01034	COG0574	Belongs to the PEP-utilizing enzyme family
LOKVESSMR4R_01035	COG3409	Peptidoglycan-binding domain 1 protein
LOKVESSMR4R_01035	COG3773	Cell wall hydrolase
LOKVESSMR4R_01036	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LOKVESSMR4R_01037	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LOKVESSMR4R_01040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LOKVESSMR4R_01041	COG1522	sequence-specific DNA binding
LOKVESSMR4R_01042	COG1522	sequence-specific DNA binding
LOKVESSMR4R_01046	COG1802	Transcriptional regulator
LOKVESSMR4R_01048	COG0505	Belongs to the CarA family
LOKVESSMR4R_01053	COG0154	amidase activity
LOKVESSMR4R_01054	COG0321	lipoyl(octanoyl) transferase activity
LOKVESSMR4R_01057	COG2951	lytic endotransglycosylase activity
LOKVESSMR4R_01062	COG1091	dTDP-4-dehydrorhamnose reductase activity
LOKVESSMR4R_01064	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LOKVESSMR4R_01065	COG1850	ribulose-bisphosphate carboxylase activity
LOKVESSMR4R_01067	COG0287	Prephenate dehydrogenase
LOKVESSMR4R_01069	COG1129	ABC transporter
LOKVESSMR4R_01072	COG3386	PFAM SMP-30 Gluconolaconase
LOKVESSMR4R_01074	COG2186	Transcriptional regulator
LOKVESSMR4R_01076	COG0019	diaminopimelate decarboxylase activity
LOKVESSMR4R_01080	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_01083	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_01085	COG3842	ATPase activity
LOKVESSMR4R_01086	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKVESSMR4R_01090	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_01090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_01092	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOKVESSMR4R_01093	COG1760	l-serine dehydratase
LOKVESSMR4R_01096	COG4372	Transposase
LOKVESSMR4R_01105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LOKVESSMR4R_01109	COG3547	Transposase (IS116 IS110 IS902 family)
LOKVESSMR4R_01110	COG2223	nitrite transmembrane transporter activity
LOKVESSMR4R_01111	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LOKVESSMR4R_01112	COG1140	nitrate reductase beta subunit
LOKVESSMR4R_01113	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LOKVESSMR4R_01114	COG2181	nitrate reductase activity
LOKVESSMR4R_01117	COG0288	reversible hydration of carbon dioxide
LOKVESSMR4R_01118	COG0303	'Molybdopterin
LOKVESSMR4R_01119	COG1618	nucleotide phosphatase activity, acting on free nucleotides
LOKVESSMR4R_01119	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LOKVESSMR4R_01121	COG2948	multi-organism process
LOKVESSMR4R_01124	COG3846	protein secretion by the type IV secretion system
LOKVESSMR4R_01127	COG3451	type IV secretory pathway VirB4
LOKVESSMR4R_01133	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LOKVESSMR4R_01134	COG0730	response to heat
LOKVESSMR4R_01136	COG2378	regulation of single-species biofilm formation
LOKVESSMR4R_01137	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LOKVESSMR4R_01139	COG0805	protein transport
LOKVESSMR4R_01142	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LOKVESSMR4R_01143	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LOKVESSMR4R_01144	COG4221	oxidoreductase activity
LOKVESSMR4R_01145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LOKVESSMR4R_01149	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LOKVESSMR4R_01151	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LOKVESSMR4R_01152	COG0418	dihydroorotase activity
LOKVESSMR4R_01153	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_01154	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKVESSMR4R_01156	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LOKVESSMR4R_01161	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LOKVESSMR4R_01165	COG0175	sulfate reduction
LOKVESSMR4R_01166	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOKVESSMR4R_01169	COG1522	sequence-specific DNA binding
LOKVESSMR4R_01172	COG0149	triose-phosphate isomerase activity
LOKVESSMR4R_01175	COG2151	metal-sulfur cluster biosynthetic enzyme
LOKVESSMR4R_01176	COG0343	queuine tRNA-ribosyltransferase activity
LOKVESSMR4R_01177	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKVESSMR4R_01187	COG0156	8-amino-7-oxononanoate synthase activity
LOKVESSMR4R_01189	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LOKVESSMR4R_01192	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LOKVESSMR4R_01193	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LOKVESSMR4R_01196	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_01196	COG3347	Dehydrogenase
LOKVESSMR4R_01199	COG1129	ABC transporter
LOKVESSMR4R_01200	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_01201	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_01202	COG3254	rhamnose metabolic process
LOKVESSMR4R_01205	COG0739	heme binding
LOKVESSMR4R_01206	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LOKVESSMR4R_01208	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LOKVESSMR4R_01211	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LOKVESSMR4R_01212	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LOKVESSMR4R_01215	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_01218	COG0516	GMP reductase activity
LOKVESSMR4R_01218	COG0517	IMP dehydrogenase activity
LOKVESSMR4R_01219	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LOKVESSMR4R_01224	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LOKVESSMR4R_01227	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LOKVESSMR4R_01229	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOKVESSMR4R_01233	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LOKVESSMR4R_01234	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LOKVESSMR4R_01235	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LOKVESSMR4R_01239	COG1138	Cytochrome C-type biogenesis protein
LOKVESSMR4R_01241	COG3088	subunit of a heme lyase
LOKVESSMR4R_01242	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_01245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKVESSMR4R_01246	COG2333	competence protein COMEC
LOKVESSMR4R_01246	COG0658	competence protein
LOKVESSMR4R_01247	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LOKVESSMR4R_01248	COG0303	'Molybdopterin
LOKVESSMR4R_01249	COG0315	cyclic pyranopterin monophosphate synthase activity
LOKVESSMR4R_01250	COG0134	indole-3-glycerol-phosphate synthase activity
LOKVESSMR4R_01251	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LOKVESSMR4R_01252	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LOKVESSMR4R_01255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LOKVESSMR4R_01258	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LOKVESSMR4R_01259	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LOKVESSMR4R_01260	COG0259	pyridoxamine-phosphate oxidase activity
LOKVESSMR4R_01261	COG1278	Cold shock
LOKVESSMR4R_01264	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOKVESSMR4R_01266	COG0148	phosphopyruvate hydratase activity
LOKVESSMR4R_01267	COG0697	spore germination
LOKVESSMR4R_01269	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LOKVESSMR4R_01270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LOKVESSMR4R_01272	COG0215	cysteine-tRNA ligase activity
LOKVESSMR4R_01273	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOKVESSMR4R_01275	COG2814	Major facilitator Superfamily
LOKVESSMR4R_01276	COG1797	cobyrinic acid a,c-diamide synthase activity
LOKVESSMR4R_01283	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LOKVESSMR4R_01283	COG4651	solute:proton antiporter activity
LOKVESSMR4R_01284	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LOKVESSMR4R_01286	COG0166	Belongs to the GPI family
LOKVESSMR4R_01288	COG0251	oxidation-reduction process
LOKVESSMR4R_01297	COG1609	Transcriptional regulator
LOKVESSMR4R_01298	COG1653	transport
LOKVESSMR4R_01299	COG1175	transmembrane transport
LOKVESSMR4R_01300	COG0395	ABC-type sugar transport system, permease component
LOKVESSMR4R_01301	COG0366	Alpha amylase catalytic
LOKVESSMR4R_01302	COG3842	ATPase activity
LOKVESSMR4R_01305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LOKVESSMR4R_01307	COG0248	Ppx GppA phosphatase
LOKVESSMR4R_01308	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LOKVESSMR4R_01310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LOKVESSMR4R_01311	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOKVESSMR4R_01314	COG2076	Multidrug Resistance protein
LOKVESSMR4R_01317	COG0538	isocitrate dehydrogenase activity
LOKVESSMR4R_01319	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LOKVESSMR4R_01320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LOKVESSMR4R_01321	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LOKVESSMR4R_01322	COG2166	iron-sulfur cluster assembly
LOKVESSMR4R_01325	COG5012	cobalamin binding
LOKVESSMR4R_01327	COG0646	methionine synthase
LOKVESSMR4R_01327	COG1410	methionine synthase
LOKVESSMR4R_01329	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LOKVESSMR4R_01330	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOKVESSMR4R_01331	COG0047	phosphoribosylformylglycinamidine synthase activity
LOKVESSMR4R_01333	COG2204	response regulator
LOKVESSMR4R_01334	COG1530	ribonuclease E activity
LOKVESSMR4R_01335	COG0425	Belongs to the sulfur carrier protein TusA family
LOKVESSMR4R_01336	COG0785	Cytochrome C biogenesis protein
LOKVESSMR4R_01338	COG2124	cytochrome p450
LOKVESSMR4R_01342	COG0114	fumarate hydratase activity
LOKVESSMR4R_01349	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOKVESSMR4R_01350	COG1999	signal sequence binding
LOKVESSMR4R_01356	COG0604	alcohol dehydrogenase
LOKVESSMR4R_01358	COG0415	Belongs to the DNA photolyase family
LOKVESSMR4R_01359	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LOKVESSMR4R_01362	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LOKVESSMR4R_01362	COG3264	Mechanosensitive ion channel
LOKVESSMR4R_01363	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOKVESSMR4R_01365	COG0628	permease
LOKVESSMR4R_01367	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LOKVESSMR4R_01373	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_01378	COG2212	antiporter activity
LOKVESSMR4R_01384	COG3108	Peptidase M15
LOKVESSMR4R_01385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKVESSMR4R_01389	COG4536	flavin adenine dinucleotide binding
LOKVESSMR4R_01390	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_01392	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LOKVESSMR4R_01393	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LOKVESSMR4R_01395	COG0629	single-stranded DNA binding
LOKVESSMR4R_01398	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LOKVESSMR4R_01399	COG0528	UMP kinase activity
LOKVESSMR4R_01400	COG0233	cytoplasmic translational termination
LOKVESSMR4R_01401	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LOKVESSMR4R_01402	COG0575	Belongs to the CDS family
LOKVESSMR4R_01403	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LOKVESSMR4R_01404	COG0750	zinc metalloprotease
LOKVESSMR4R_01405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOKVESSMR4R_01407	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LOKVESSMR4R_01408	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKVESSMR4R_01410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKVESSMR4R_01413	COG0697	spore germination
LOKVESSMR4R_01414	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_01420	COG2205	protein histidine kinase activity
LOKVESSMR4R_01421	COG2308	Evidence 4 Homologs of previously reported genes of
LOKVESSMR4R_01425	COG1902	pentaerythritol trinitrate reductase activity
LOKVESSMR4R_01425	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_01432	COG3743	rRNA binding
LOKVESSMR4R_01432	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LOKVESSMR4R_01433	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LOKVESSMR4R_01435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LOKVESSMR4R_01436	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LOKVESSMR4R_01444	COG1612	heme a metabolic process
LOKVESSMR4R_01445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LOKVESSMR4R_01449	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKVESSMR4R_01450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LOKVESSMR4R_01451	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LOKVESSMR4R_01452	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_01453	COG1177	transmembrane transport
LOKVESSMR4R_01454	COG3842	ATPase activity
LOKVESSMR4R_01456	COG1309	transcriptional regulator
LOKVESSMR4R_01458	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LOKVESSMR4R_01461	COG0482	sulfurtransferase activity
LOKVESSMR4R_01464	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LOKVESSMR4R_01465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LOKVESSMR4R_01468	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LOKVESSMR4R_01469	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKVESSMR4R_01470	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LOKVESSMR4R_01471	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LOKVESSMR4R_01472	COG2423	ornithine cyclodeaminase activity
LOKVESSMR4R_01476	COG1238	metal cluster binding
LOKVESSMR4R_01479	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LOKVESSMR4R_01485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LOKVESSMR4R_01486	COG2814	Major facilitator Superfamily
LOKVESSMR4R_01489	COG4166	transmembrane transport
LOKVESSMR4R_01490	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_01494	COG2313	pseudouridylate synthase activity
LOKVESSMR4R_01498	COG0052	Belongs to the universal ribosomal protein uS2 family
LOKVESSMR4R_01499	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LOKVESSMR4R_01500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LOKVESSMR4R_01505	COG0704	Plays a role in the regulation of phosphate uptake
LOKVESSMR4R_01506	COG5002	protein histidine kinase activity
LOKVESSMR4R_01509	COG0194	GDP metabolic process
LOKVESSMR4R_01510	COG1561	YicC-like family, N-terminal region
LOKVESSMR4R_01512	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LOKVESSMR4R_01521	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LOKVESSMR4R_01522	COG1923	regulation of RNA biosynthetic process
LOKVESSMR4R_01524	COG0569	domain protein
LOKVESSMR4R_01525	COG2204	response regulator
LOKVESSMR4R_01526	COG5000	phosphorelay sensor kinase activity
LOKVESSMR4R_01527	COG2204	response regulator
LOKVESSMR4R_01528	COG3852	Histidine kinase
LOKVESSMR4R_01529	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LOKVESSMR4R_01530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LOKVESSMR4R_01530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LOKVESSMR4R_01531	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LOKVESSMR4R_01532	COG1546	Belongs to the CinA family
LOKVESSMR4R_01543	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01544	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01547	COG0747	negative chemotaxis
LOKVESSMR4R_01550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LOKVESSMR4R_01562	COG4372	Transposase
LOKVESSMR4R_01563	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_01564	COG2963	transposase activity
LOKVESSMR4R_01568	COG0250	Participates in transcription elongation, termination and antitermination
LOKVESSMR4R_01579	COG1083	cytidylyl-transferase
LOKVESSMR4R_01582	COG0662	Cupin 2, conserved barrel domain protein
LOKVESSMR4R_01582	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LOKVESSMR4R_01583	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOKVESSMR4R_01584	COG1088	dTDP-glucose 4,6-dehydratase activity
LOKVESSMR4R_01586	COG0297	glycogen (starch) synthase activity
LOKVESSMR4R_01588	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LOKVESSMR4R_01593	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOKVESSMR4R_01603	COG0719	Fe-S assembly protein
LOKVESSMR4R_01604	COG0396	ATPase activity
LOKVESSMR4R_01605	COG0719	Fe-S assembly protein
LOKVESSMR4R_01608	COG2945	thiolester hydrolase activity
LOKVESSMR4R_01610	COG0513	Belongs to the DEAD box helicase family
LOKVESSMR4R_01614	COG0105	UTP biosynthetic process
LOKVESSMR4R_01615	COG0488	(ABC) transporter
LOKVESSMR4R_01616	COG2095	MarC family integral membrane protein
LOKVESSMR4R_01617	COG3577	Aspartyl protease
LOKVESSMR4R_01619	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOKVESSMR4R_01624	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LOKVESSMR4R_01625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LOKVESSMR4R_01627	COG2890	protein-(glutamine-N5) methyltransferase activity
LOKVESSMR4R_01628	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LOKVESSMR4R_01631	COG0010	Belongs to the arginase family
LOKVESSMR4R_01633	COG3956	TIGRFAM MazG family protein
LOKVESSMR4R_01634	COG1840	ABC-type Fe3 transport system, periplasmic component
LOKVESSMR4R_01638	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKVESSMR4R_01641	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LOKVESSMR4R_01642	COG0416	fatty acid biosynthetic process
LOKVESSMR4R_01643	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LOKVESSMR4R_01644	COG0776	regulation of translation
LOKVESSMR4R_01647	COG0717	Belongs to the dCTP deaminase family
LOKVESSMR4R_01649	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LOKVESSMR4R_01650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LOKVESSMR4R_01651	COG1472	Belongs to the glycosyl hydrolase 3 family
LOKVESSMR4R_01653	COG0018	arginyl-trna synthetase
LOKVESSMR4R_01654	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LOKVESSMR4R_01655	COG0316	Belongs to the HesB IscA family
LOKVESSMR4R_01658	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LOKVESSMR4R_01663	COG0501	Belongs to the peptidase M48B family
LOKVESSMR4R_01667	COG0129	dihydroxy-acid dehydratase activity
LOKVESSMR4R_01668	COG0800	Aldolase
LOKVESSMR4R_01669	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_01671	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LOKVESSMR4R_01674	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LOKVESSMR4R_01675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKVESSMR4R_01677	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKVESSMR4R_01681	COG0625	glutathione transferase activity
LOKVESSMR4R_01683	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_01684	COG0440	acetolactate synthase activity
LOKVESSMR4R_01687	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LOKVESSMR4R_01688	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LOKVESSMR4R_01689	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LOKVESSMR4R_01691	COG1830	Aldolase
LOKVESSMR4R_01693	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LOKVESSMR4R_01694	COG0022	dehydrogenase e1 component
LOKVESSMR4R_01694	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_01695	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_01712	COG4695	Portal protein
LOKVESSMR4R_01714	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LOKVESSMR4R_01715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOKVESSMR4R_01716	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOKVESSMR4R_01718	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LOKVESSMR4R_01721	COG2353	YceI-like domain
LOKVESSMR4R_01722	COG0360	Binds together with S18 to 16S ribosomal RNA
LOKVESSMR4R_01723	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LOKVESSMR4R_01724	COG0359	binds to the 23S rRNA
LOKVESSMR4R_01727	COG0544	peptidyl-prolyl cis-trans isomerase activity
LOKVESSMR4R_01729	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LOKVESSMR4R_01729	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LOKVESSMR4R_01735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LOKVESSMR4R_01740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LOKVESSMR4R_01743	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LOKVESSMR4R_01744	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKVESSMR4R_01746	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LOKVESSMR4R_01747	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LOKVESSMR4R_01748	COG4133	protoheme IX ABC transporter activity
LOKVESSMR4R_01749	COG3737	Protein of unknown function (DUF498/DUF598)
LOKVESSMR4R_01750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LOKVESSMR4R_01751	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LOKVESSMR4R_01753	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LOKVESSMR4R_01755	COG1160	GTP binding
LOKVESSMR4R_01759	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKVESSMR4R_01760	COG5265	(ABC) transporter
LOKVESSMR4R_01766	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_01766	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_01769	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_01770	COG4235	cytochrome complex assembly
LOKVESSMR4R_01771	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LOKVESSMR4R_01773	COG3842	ATPase activity
LOKVESSMR4R_01774	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_01778	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LOKVESSMR4R_01781	COG0513	Belongs to the DEAD box helicase family
LOKVESSMR4R_01783	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LOKVESSMR4R_01785	COG1007	ATP synthesis coupled electron transport
LOKVESSMR4R_01788	COG0713	ATP synthesis coupled electron transport
LOKVESSMR4R_01791	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOKVESSMR4R_01792	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LOKVESSMR4R_01799	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LOKVESSMR4R_01799	COG3743	rRNA binding
LOKVESSMR4R_01804	COG0649	NAD binding
LOKVESSMR4R_01806	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOKVESSMR4R_01807	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOKVESSMR4R_01812	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LOKVESSMR4R_01815	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_01816	COG0546	phosphoglycolate phosphatase activity
LOKVESSMR4R_01817	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LOKVESSMR4R_01818	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LOKVESSMR4R_01820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LOKVESSMR4R_01822	COG1473	amidohydrolase
LOKVESSMR4R_01826	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LOKVESSMR4R_01831	COG1295	ribonuclease BN
LOKVESSMR4R_01836	COG1175	transmembrane transport
LOKVESSMR4R_01838	COG1404	Belongs to the peptidase S8 family
LOKVESSMR4R_01843	COG1294	oxidase, subunit
LOKVESSMR4R_01844	COG1271	oxidase subunit
LOKVESSMR4R_01845	COG1959	2 iron, 2 sulfur cluster binding
LOKVESSMR4R_01846	COG4604	ABC transporter, ATP-binding protein
LOKVESSMR4R_01847	COG4605	iron ion homeostasis
LOKVESSMR4R_01848	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOKVESSMR4R_01849	COG4607	ABC-type enterochelin transport system periplasmic component
LOKVESSMR4R_01851	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_01852	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_01853	COG4771	TonB-dependent receptor
LOKVESSMR4R_01854	COG0747	negative chemotaxis
LOKVESSMR4R_01855	COG0601	transmembrane transport
LOKVESSMR4R_01856	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_01857	COG4172	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01863	COG0573	inorganic phosphate transmembrane transporter activity
LOKVESSMR4R_01864	COG0581	inorganic phosphate transmembrane transporter activity
LOKVESSMR4R_01865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LOKVESSMR4R_01866	COG0704	Plays a role in the regulation of phosphate uptake
LOKVESSMR4R_01867	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_01868	COG1312	Catalyzes the dehydration of D-mannonate
LOKVESSMR4R_01869	COG2721	sulfolactate sulfo-lyase activity
LOKVESSMR4R_01870	COG0246	Mannitol dehydrogenase
LOKVESSMR4R_01871	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_01872	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LOKVESSMR4R_01873	COG1917	Cupin 2, conserved barrel domain protein
LOKVESSMR4R_01876	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKVESSMR4R_01877	COG1904	glucuronate isomerase
LOKVESSMR4R_01879	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_01881	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_01885	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01886	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01887	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_01893	COG0811	peptide transport
LOKVESSMR4R_01895	COG1629	transport
LOKVESSMR4R_01896	COG3720	iron ion transport
LOKVESSMR4R_01897	COG4558	Periplasmic binding protein
LOKVESSMR4R_01898	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOKVESSMR4R_01899	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LOKVESSMR4R_01904	COG1595	DNA-templated transcription, initiation
LOKVESSMR4R_01906	COG3220	belongs to the UPF0276 family
LOKVESSMR4R_01909	COG3920	Histidine kinase
LOKVESSMR4R_01910	COG2226	methyltransferase
LOKVESSMR4R_01911	COG0702	epimerase
LOKVESSMR4R_01912	COG1733	regulation of RNA biosynthetic process
LOKVESSMR4R_01920	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_01923	COG0033	Phosphoglucomutase
LOKVESSMR4R_01928	COG3842	ATPase activity
LOKVESSMR4R_01930	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_01933	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LOKVESSMR4R_01933	COG0321	lipoyl(octanoyl) transferase activity
LOKVESSMR4R_01934	COG0084	hydrolase, TatD family'
LOKVESSMR4R_01936	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LOKVESSMR4R_01937	COG1686	Belongs to the peptidase S11 family
LOKVESSMR4R_01941	COG0154	amidase activity
LOKVESSMR4R_01942	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01943	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_01944	COG0601	transmembrane transport
LOKVESSMR4R_01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_01946	COG0747	negative chemotaxis
LOKVESSMR4R_01949	COG3454	Phosphonate metabolism
LOKVESSMR4R_01950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LOKVESSMR4R_01952	COG4778	phosphonate C-P lyase system protein PhnL
LOKVESSMR4R_01953	COG4107	phosphonate C-P lyase system protein PhnK
LOKVESSMR4R_01954	COG3627	carbon phosphorus lyase activity
LOKVESSMR4R_01955	COG3626	phosphonate metabolism
LOKVESSMR4R_01957	COG3624	Phosphonate C-P lyase system protein PhnG
LOKVESSMR4R_01958	COG2188	Transcriptional regulator
LOKVESSMR4R_01959	COG3454	Phosphonate metabolism
LOKVESSMR4R_01961	COG3639	organic phosphonate transmembrane transporter activity
LOKVESSMR4R_01962	COG3639	organic phosphonate transmembrane transporter activity
LOKVESSMR4R_01963	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LOKVESSMR4R_01964	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LOKVESSMR4R_01967	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LOKVESSMR4R_01970	COG3218	ABC-type transport auxiliary lipoprotein component
LOKVESSMR4R_01970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LOKVESSMR4R_01971	COG1127	ABC transporter
LOKVESSMR4R_01972	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LOKVESSMR4R_01978	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_01983	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKVESSMR4R_01985	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_01986	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKVESSMR4R_01987	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LOKVESSMR4R_01988	COG4989	oxidoreductase activity
LOKVESSMR4R_01992	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKVESSMR4R_01997	COG2115	Belongs to the xylose isomerase family
LOKVESSMR4R_01998	COG1070	Carbohydrate kinase
LOKVESSMR4R_02000	COG4214	carbohydrate transport
LOKVESSMR4R_02001	COG4213	ABC transporter substrate-binding protein
LOKVESSMR4R_02002	COG1940	carbohydrate kinase activity
LOKVESSMR4R_02004	COG1858	cytochrome C peroxidase
LOKVESSMR4R_02011	COG1178	ABC-type Fe3 transport system permease component
LOKVESSMR4R_02013	COG3750	Belongs to the UPF0335 family
LOKVESSMR4R_02016	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_02017	COG0640	Transcriptional regulator
LOKVESSMR4R_02019	COG2391	methyltransferase activity
LOKVESSMR4R_02025	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_02028	COG0511	ligase activity, forming carbon-carbon bonds
LOKVESSMR4R_02029	COG0439	Biotin carboxylase
LOKVESSMR4R_02030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LOKVESSMR4R_02033	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LOKVESSMR4R_02034	COG0740	serine-type endopeptidase activity
LOKVESSMR4R_02035	COG1469	GTP cyclohydrolase I activity
LOKVESSMR4R_02038	COG2917	probably involved in intracellular septation
LOKVESSMR4R_02040	COG0552	protein localization to endoplasmic reticulum
LOKVESSMR4R_02047	COG1329	Transcriptional regulator
LOKVESSMR4R_02049	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LOKVESSMR4R_02055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LOKVESSMR4R_02055	COG1793	dna ligase
LOKVESSMR4R_02058	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LOKVESSMR4R_02059	COG0564	pseudouridine synthase activity
LOKVESSMR4R_02066	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LOKVESSMR4R_02067	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LOKVESSMR4R_02068	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LOKVESSMR4R_02068	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LOKVESSMR4R_02073	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LOKVESSMR4R_02073	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LOKVESSMR4R_02074	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LOKVESSMR4R_02075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LOKVESSMR4R_02076	COG0358	DNA primase activity
LOKVESSMR4R_02078	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_02078	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_02080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_02081	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LOKVESSMR4R_02090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LOKVESSMR4R_02092	COG0346	lactoylglutathione lyase activity
LOKVESSMR4R_02093	COG1846	Transcriptional regulator
LOKVESSMR4R_02098	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOKVESSMR4R_02099	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKVESSMR4R_02102	COG1363	Peptidase, m42
LOKVESSMR4R_02104	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LOKVESSMR4R_02108	COG0534	Mate efflux family protein
LOKVESSMR4R_02113	COG0187	DNA topoisomerase II activity
LOKVESSMR4R_02115	COG2010	Cytochrome c
LOKVESSMR4R_02117	COG1136	(ABC) transporter
LOKVESSMR4R_02119	COG0442	prolyl-tRNA aminoacylation
LOKVESSMR4R_02120	COG0628	permease
LOKVESSMR4R_02122	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LOKVESSMR4R_02123	COG0248	Ppx GppA phosphatase
LOKVESSMR4R_02124	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LOKVESSMR4R_02131	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LOKVESSMR4R_02133	COG3800	Transcriptional regulator
LOKVESSMR4R_02133	COG1396	sequence-specific DNA binding
LOKVESSMR4R_02138	COG3119	arylsulfatase activity
LOKVESSMR4R_02139	COG1309	transcriptional regulator
LOKVESSMR4R_02142	COG4175	Glycine betaine
LOKVESSMR4R_02144	COG1692	metallophosphoesterase
LOKVESSMR4R_02146	COG3273	potassium ion transport
LOKVESSMR4R_02146	COG0471	metal ion transport
LOKVESSMR4R_02147	COG0217	transcriptional regulatory protein
LOKVESSMR4R_02148	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LOKVESSMR4R_02149	COG2239	Acts as a magnesium transporter
LOKVESSMR4R_02150	COG0402	S-adenosylhomocysteine deaminase activity
LOKVESSMR4R_02151	COG0483	inositol monophosphate 1-phosphatase activity
LOKVESSMR4R_02152	COG1396	sequence-specific DNA binding
LOKVESSMR4R_02154	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_02156	COG0670	Belongs to the BI1 family
LOKVESSMR4R_02157	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LOKVESSMR4R_02160	COG3023	N-Acetylmuramoyl-L-alanine amidase
LOKVESSMR4R_02162	COG0154	amidase activity
LOKVESSMR4R_02163	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOKVESSMR4R_02165	COG0590	tRNA wobble adenosine to inosine editing
LOKVESSMR4R_02166	COG1187	pseudouridine synthase activity
LOKVESSMR4R_02176	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKVESSMR4R_02177	COG1121	(ABC) transporter
LOKVESSMR4R_02178	COG0735	belongs to the Fur family
LOKVESSMR4R_02179	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LOKVESSMR4R_02182	COG3706	GGDEF domain
LOKVESSMR4R_02182	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_02192	COG0667	Aldo Keto reductase
LOKVESSMR4R_02194	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKVESSMR4R_02195	COG1083	cytidylyl-transferase
LOKVESSMR4R_02197	COG2089	acid synthase
LOKVESSMR4R_02201	COG0012	GTP binding
LOKVESSMR4R_02202	COG0159	tryptophan synthase activity
LOKVESSMR4R_02203	COG1304	FMN binding
LOKVESSMR4R_02208	COG0193	aminoacyl-tRNA hydrolase activity
LOKVESSMR4R_02211	COG0133	tryptophan synthase activity
LOKVESSMR4R_02212	COG0135	phosphoribosylanthranilate isomerase activity
LOKVESSMR4R_02214	COG0776	regulation of translation
LOKVESSMR4R_02215	COG0539	negative regulation of cytoplasmic translation
LOKVESSMR4R_02217	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LOKVESSMR4R_02218	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LOKVESSMR4R_02219	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LOKVESSMR4R_02220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LOKVESSMR4R_02222	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LOKVESSMR4R_02223	COG1253	flavin adenine dinucleotide binding
LOKVESSMR4R_02224	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LOKVESSMR4R_02225	COG1702	phosphate starvation-inducible protein PhoH
LOKVESSMR4R_02226	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKVESSMR4R_02228	COG1943	Transposase
LOKVESSMR4R_02230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LOKVESSMR4R_02232	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOKVESSMR4R_02233	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LOKVESSMR4R_02234	COG1047	Peptidyl-prolyl cis-trans
LOKVESSMR4R_02238	COG0596	Alpha beta hydrolase
LOKVESSMR4R_02243	COG3773	Cell wall hydrolase
LOKVESSMR4R_02246	COG0110	maltose O-acetyltransferase activity
LOKVESSMR4R_02247	COG0297	glycogen (starch) synthase activity
LOKVESSMR4R_02248	COG0110	maltose O-acetyltransferase activity
LOKVESSMR4R_02254	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOKVESSMR4R_02255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LOKVESSMR4R_02256	COG0725	ABC transporter, periplasmic molybdate-binding protein
LOKVESSMR4R_02257	COG4149	molybdate abc transporter
LOKVESSMR4R_02258	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LOKVESSMR4R_02262	COG1834	amidinotransferase
LOKVESSMR4R_02263	COG1309	transcriptional regulator
LOKVESSMR4R_02267	COG3246	L-lysine catabolic process to acetate
LOKVESSMR4R_02268	COG0824	Thioesterase
LOKVESSMR4R_02268	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_02269	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_02271	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_02272	COG3685	Protein conserved in bacteria
LOKVESSMR4R_02274	COG2323	membrane
LOKVESSMR4R_02285	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_02287	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKVESSMR4R_02288	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LOKVESSMR4R_02289	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_02290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKVESSMR4R_02291	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_02293	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_02304	COG1196	nuclear chromosome segregation
LOKVESSMR4R_02304	COG0741	lytic transglycosylase activity
LOKVESSMR4R_02304	COG0739	heme binding
LOKVESSMR4R_02307	COG0556	nucleotide-excision repair
LOKVESSMR4R_02312	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_02313	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_02315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKVESSMR4R_02316	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKVESSMR4R_02318	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKVESSMR4R_02319	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_02322	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LOKVESSMR4R_02323	COG0243	molybdopterin cofactor binding
LOKVESSMR4R_02325	COG0437	4 iron, 4 sulfur cluster binding
LOKVESSMR4R_02327	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_02329	COG1414	Transcriptional regulator
LOKVESSMR4R_02331	COG1175	transmembrane transport
LOKVESSMR4R_02333	COG0395	ABC-type sugar transport system, permease component
LOKVESSMR4R_02335	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_02336	COG3734	2-keto-3-deoxy-galactonokinase
LOKVESSMR4R_02337	COG0800	Aldolase
LOKVESSMR4R_02338	COG3386	PFAM SMP-30 Gluconolaconase
LOKVESSMR4R_02341	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LOKVESSMR4R_02342	COG0709	Synthesizes selenophosphate from selenide and ATP
LOKVESSMR4R_02343	COG0259	pyridoxamine-phosphate oxidase activity
LOKVESSMR4R_02346	COG1136	(ABC) transporter
LOKVESSMR4R_02347	COG0183	Belongs to the thiolase family
LOKVESSMR4R_02349	COG3022	response to hydroperoxide
LOKVESSMR4R_02352	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LOKVESSMR4R_02353	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LOKVESSMR4R_02354	COG1940	carbohydrate kinase activity
LOKVESSMR4R_02356	COG0037	tRNA processing
LOKVESSMR4R_02358	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LOKVESSMR4R_02359	COG0594	ribonuclease P activity
LOKVESSMR4R_02360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LOKVESSMR4R_02362	COG4251	negative regulation of phosphorylation
LOKVESSMR4R_02366	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_02386	COG0582	viral genome integration into host DNA
LOKVESSMR4R_02401	COG0582	viral genome integration into host DNA
LOKVESSMR4R_02404	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_02418	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKVESSMR4R_02424	COG2909	trisaccharide binding
LOKVESSMR4R_02425	COG0601	transmembrane transport
LOKVESSMR4R_02435	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LOKVESSMR4R_02437	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOKVESSMR4R_02439	COG1335	isochorismatase
LOKVESSMR4R_02440	COG0778	Nitroreductase
LOKVESSMR4R_02441	COG0154	amidase activity
LOKVESSMR4R_02444	COG1129	ABC transporter
LOKVESSMR4R_02448	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LOKVESSMR4R_02449	COG0154	amidase activity
LOKVESSMR4R_02450	COG0154	amidase activity
LOKVESSMR4R_02451	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LOKVESSMR4R_02457	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_02458	COG1070	Carbohydrate kinase
LOKVESSMR4R_02466	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_02469	COG3842	ATPase activity
LOKVESSMR4R_02472	COG1760	l-serine dehydratase
LOKVESSMR4R_02475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_02481	COG0659	secondary active sulfate transmembrane transporter activity
LOKVESSMR4R_02483	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LOKVESSMR4R_02483	COG0316	Belongs to the HesB IscA family
LOKVESSMR4R_02484	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_02485	COG1846	Transcriptional regulator
LOKVESSMR4R_02486	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LOKVESSMR4R_02487	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_02488	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_02489	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LOKVESSMR4R_02490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKVESSMR4R_02493	COG2022	thiamine diphosphate biosynthetic process
LOKVESSMR4R_02496	COG0351	phosphomethylpyrimidine kinase
LOKVESSMR4R_02499	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOKVESSMR4R_02500	COG1609	Transcriptional regulator
LOKVESSMR4R_02501	COG1879	ABC-type sugar transport system periplasmic component
LOKVESSMR4R_02502	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_02503	COG1129	ABC transporter
LOKVESSMR4R_02504	COG1082	Xylose isomerase domain protein TIM barrel
LOKVESSMR4R_02505	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_02507	COG2963	transposase activity
LOKVESSMR4R_02508	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_02509	COG4372	Transposase
LOKVESSMR4R_02511	COG2205	protein histidine kinase activity
LOKVESSMR4R_02518	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKVESSMR4R_02539	COG3293	Transposase
LOKVESSMR4R_02542	COG3833	ABC-type maltose transport systems, permease component
LOKVESSMR4R_02543	COG3842	ATPase activity
LOKVESSMR4R_02544	COG0584	glycerophosphoryl diester phosphodiesterase
LOKVESSMR4R_02545	COG1609	Transcriptional regulator
LOKVESSMR4R_02546	COG0483	inositol monophosphate 1-phosphatase activity
LOKVESSMR4R_02549	COG1475	DNA binding
LOKVESSMR4R_02566	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOKVESSMR4R_02594	COG1061	Type III restriction enzyme res subunit
LOKVESSMR4R_02595	COG1002	Type II restriction enzyme, methylase subunits
LOKVESSMR4R_02599	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_02602	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_02603	COG1129	ABC transporter
LOKVESSMR4R_02607	COG1940	carbohydrate kinase activity
LOKVESSMR4R_02610	COG2925	Exonuclease
LOKVESSMR4R_02611	COG3177	Filamentation induced by cAMP protein fic
LOKVESSMR4R_02625	COG0523	cobalamin synthesis protein
LOKVESSMR4R_02630	COG1122	ATPase activity
LOKVESSMR4R_02636	COG1522	sequence-specific DNA binding
LOKVESSMR4R_02637	COG0506	proline dehydrogenase activity
LOKVESSMR4R_02637	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LOKVESSMR4R_02637	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LOKVESSMR4R_02639	COG0483	inositol monophosphate 1-phosphatase activity
LOKVESSMR4R_02640	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_02645	COG0525	valine-tRNA ligase activity
LOKVESSMR4R_02646	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LOKVESSMR4R_02647	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LOKVESSMR4R_02648	COG0354	folic acid binding
LOKVESSMR4R_02649	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LOKVESSMR4R_02651	COG1492	cobalamin metabolic process
LOKVESSMR4R_02654	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LOKVESSMR4R_02660	COG2943	transferase activity, transferring hexosyl groups
LOKVESSMR4R_02662	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LOKVESSMR4R_02664	COG0450	alkyl hydroperoxide reductase
LOKVESSMR4R_02665	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_02667	COG1162	GTPase activity
LOKVESSMR4R_02670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LOKVESSMR4R_02671	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LOKVESSMR4R_02679	COG0714	Associated with various cellular activities
LOKVESSMR4R_02684	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_02685	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_02686	COG0247	lactate metabolic process
LOKVESSMR4R_02688	COG0071	Belongs to the small heat shock protein (HSP20) family
LOKVESSMR4R_02689	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LOKVESSMR4R_02689	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LOKVESSMR4R_02692	COG1131	(ABC) transporter
LOKVESSMR4R_02697	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_02698	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LOKVESSMR4R_02701	COG2186	Transcriptional regulator
LOKVESSMR4R_02702	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LOKVESSMR4R_02704	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOKVESSMR4R_02705	COG0356	it plays a direct role in the translocation of protons across the membrane
LOKVESSMR4R_02712	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LOKVESSMR4R_02715	COG0228	four-way junction DNA binding
LOKVESSMR4R_02717	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LOKVESSMR4R_02718	COG0336	Belongs to the RNA methyltransferase TrmD family
LOKVESSMR4R_02719	COG0335	large ribosomal subunit rRNA binding
LOKVESSMR4R_02720	COG0254	rRNA binding
LOKVESSMR4R_02721	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_02722	COG0513	Belongs to the DEAD box helicase family
LOKVESSMR4R_02723	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_02723	COG2151	metal-sulfur cluster biosynthetic enzyme
LOKVESSMR4R_02724	COG0697	spore germination
LOKVESSMR4R_02725	COG0473	3-isopropylmalate dehydrogenase activity
LOKVESSMR4R_02728	COG0066	3-isopropylmalate dehydratase activity
LOKVESSMR4R_02729	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LOKVESSMR4R_02731	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LOKVESSMR4R_02732	COG0830	nickel cation binding
LOKVESSMR4R_02733	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LOKVESSMR4R_02735	COG0804	urea catabolic process
LOKVESSMR4R_02736	COG0832	Belongs to the urease beta subunit family
LOKVESSMR4R_02737	COG0831	urea catabolic process
LOKVESSMR4R_02738	COG0829	nickel cation binding
LOKVESSMR4R_02741	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LOKVESSMR4R_02744	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LOKVESSMR4R_02745	COG0667	Aldo Keto reductase
LOKVESSMR4R_02753	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LOKVESSMR4R_02754	COG0756	dUTP diphosphatase activity
LOKVESSMR4R_02755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LOKVESSMR4R_02756	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LOKVESSMR4R_02760	COG0606	chelatase, subunit chli
LOKVESSMR4R_02761	COG0189	ligase activity
LOKVESSMR4R_02763	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LOKVESSMR4R_02765	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LOKVESSMR4R_02766	COG0728	peptidoglycan biosynthetic process
LOKVESSMR4R_02768	COG0180	Tryptophanyl-tRNA synthetase
LOKVESSMR4R_02769	COG2514	catechol 2,3-dioxygenase activity
LOKVESSMR4R_02771	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LOKVESSMR4R_02782	COG0730	response to heat
LOKVESSMR4R_02784	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_02785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LOKVESSMR4R_02787	COG2937	Belongs to the GPAT DAPAT family
LOKVESSMR4R_02791	COG0813	purine-nucleoside phosphorylase activity
LOKVESSMR4R_02800	COG2030	dehydratase
LOKVESSMR4R_02806	COG0039	L-malate dehydrogenase activity
LOKVESSMR4R_02807	COG0045	succinate-CoA ligase (ADP-forming) activity
LOKVESSMR4R_02808	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LOKVESSMR4R_02810	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_02814	COG1802	Transcriptional regulator
LOKVESSMR4R_02822	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LOKVESSMR4R_02824	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKVESSMR4R_02828	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LOKVESSMR4R_02829	COG3257	ureidoglycine aminohydrolase activity
LOKVESSMR4R_02830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_02833	COG0741	lytic transglycosylase activity
LOKVESSMR4R_02834	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOKVESSMR4R_02835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LOKVESSMR4R_02836	COG2897	thiosulfate sulfurtransferase activity
LOKVESSMR4R_02838	COG2301	Belongs to the HpcH HpaI aldolase family
LOKVESSMR4R_02839	COG0825	malonyl-CoA metabolic process
LOKVESSMR4R_02842	COG2884	Cell division ATP-binding protein ftsE
LOKVESSMR4R_02845	COG0019	diaminopimelate decarboxylase activity
LOKVESSMR4R_02848	COG0165	Argininosuccinate lyase
LOKVESSMR4R_02849	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKVESSMR4R_02850	COG1678	Uncharacterized ACR, COG1678
LOKVESSMR4R_02854	COG0521	Mo-molybdopterin cofactor biosynthetic process
LOKVESSMR4R_02855	COG1573	uracil-dna glycosylase
LOKVESSMR4R_02856	COG0540	Belongs to the ATCase OTCase family
LOKVESSMR4R_02858	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LOKVESSMR4R_02859	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LOKVESSMR4R_02863	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LOKVESSMR4R_02864	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LOKVESSMR4R_02865	COG2885	chlorophyll binding
LOKVESSMR4R_02867	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LOKVESSMR4R_02868	COG0009	L-threonylcarbamoyladenylate synthase
LOKVESSMR4R_02869	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_02873	COG1522	sequence-specific DNA binding
LOKVESSMR4R_02878	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LOKVESSMR4R_02880	COG1763	Mo-molybdopterin cofactor biosynthetic process
LOKVESSMR4R_02881	COG0303	'Molybdopterin
LOKVESSMR4R_02885	COG1309	transcriptional regulator
LOKVESSMR4R_02887	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LOKVESSMR4R_02893	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOKVESSMR4R_02895	COG0288	reversible hydration of carbon dioxide
LOKVESSMR4R_02898	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LOKVESSMR4R_02899	COG0596	Alpha beta hydrolase
LOKVESSMR4R_02900	COG2423	ornithine cyclodeaminase activity
LOKVESSMR4R_02902	COG1671	Belongs to the UPF0178 family
LOKVESSMR4R_02903	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LOKVESSMR4R_02906	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LOKVESSMR4R_02908	COG0793	Belongs to the peptidase S41A family
LOKVESSMR4R_02909	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LOKVESSMR4R_02910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LOKVESSMR4R_02911	COG0799	negative regulation of ribosome biogenesis
LOKVESSMR4R_02912	COG1063	alcohol dehydrogenase
LOKVESSMR4R_02913	COG0708	Exodeoxyribonuclease III
LOKVESSMR4R_02916	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LOKVESSMR4R_02918	COG3265	gluconokinase activity
LOKVESSMR4R_02923	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKVESSMR4R_02924	COG4948	Mandelate Racemase Muconate Lactonizing
LOKVESSMR4R_02926	COG0004	ammonium transporteR
LOKVESSMR4R_02927	COG0347	Belongs to the P(II) protein family
LOKVESSMR4R_02930	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
LOKVESSMR4R_02931	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKVESSMR4R_02935	COG2154	pterin-4-alpha-carbinolamine dehydratase
LOKVESSMR4R_02936	COG0668	transmembrane transport
LOKVESSMR4R_02937	COG0678	peroxiredoxin activity
LOKVESSMR4R_02939	COG0742	ribosomal rna small subunit methyltransferase
LOKVESSMR4R_02940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LOKVESSMR4R_02943	COG0285	dihydrofolate synthase activity
LOKVESSMR4R_02944	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LOKVESSMR4R_02946	COG0129	dihydroxy-acid dehydratase activity
LOKVESSMR4R_02950	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_02950	COG1902	pentaerythritol trinitrate reductase activity
LOKVESSMR4R_02951	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_02952	COG3706	GGDEF domain
LOKVESSMR4R_02956	COG1058	Belongs to the CinA family
LOKVESSMR4R_02956	COG1546	Belongs to the CinA family
LOKVESSMR4R_02957	COG0024	Methionine aminopeptidase
LOKVESSMR4R_02960	COG0142	geranyltranstransferase activity
LOKVESSMR4R_02967	COG2200	EAL domain
LOKVESSMR4R_02968	COG2818	Glycosylase
LOKVESSMR4R_02969	COG0314	molybdopterin synthase activity
LOKVESSMR4R_02971	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LOKVESSMR4R_02972	COG0322	excinuclease ABC activity
LOKVESSMR4R_02975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LOKVESSMR4R_02975	COG0616	signal peptide processing
LOKVESSMR4R_02976	COG0842	Transport permease protein
LOKVESSMR4R_02977	COG1131	(ABC) transporter
LOKVESSMR4R_02979	COG3266	domain, Protein
LOKVESSMR4R_02979	COG0515	serine threonine protein kinase
LOKVESSMR4R_02983	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LOKVESSMR4R_02989	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_02990	COG0523	cobalamin synthesis protein
LOKVESSMR4R_02997	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LOKVESSMR4R_03001	COG0471	metal ion transport
LOKVESSMR4R_03001	COG3273	potassium ion transport
LOKVESSMR4R_03002	COG0589	response to stress
LOKVESSMR4R_03003	COG0659	secondary active sulfate transmembrane transporter activity
LOKVESSMR4R_03006	COG0352	thiamine-phosphate diphosphorylase activity
LOKVESSMR4R_03007	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LOKVESSMR4R_03009	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_03011	COG1335	isochorismatase
LOKVESSMR4R_03013	COG1177	transmembrane transport
LOKVESSMR4R_03014	COG3842	ATPase activity
LOKVESSMR4R_03021	COG3665	Urea carboxylase-associated protein
LOKVESSMR4R_03032	COG0784	Response regulator, receiver
LOKVESSMR4R_03040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKVESSMR4R_03045	COG0706	membrane insertase activity
LOKVESSMR4R_03046	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LOKVESSMR4R_03047	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LOKVESSMR4R_03050	COG1126	abc transporter atp-binding protein
LOKVESSMR4R_03051	COG0765	amino acid transport
LOKVESSMR4R_03052	COG4597	amino acid ABC transporter
LOKVESSMR4R_03053	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKVESSMR4R_03055	COG0546	phosphoglycolate phosphatase activity
LOKVESSMR4R_03056	COG0564	pseudouridine synthase activity
LOKVESSMR4R_03057	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LOKVESSMR4R_03058	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LOKVESSMR4R_03061	COG0202	RNA polymerase activity
LOKVESSMR4R_03062	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LOKVESSMR4R_03063	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LOKVESSMR4R_03064	COG0563	adenylate kinase activity
LOKVESSMR4R_03065	COG0201	protein transport
LOKVESSMR4R_03066	COG0200	Binds to the 23S rRNA
LOKVESSMR4R_03067	COG3842	ATPase activity
LOKVESSMR4R_03069	COG1175	transmembrane transport
LOKVESSMR4R_03073	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_03094	COG3501	Rhs element vgr protein
LOKVESSMR4R_03115	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_03119	COG1475	DNA binding
LOKVESSMR4R_03138	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOKVESSMR4R_03155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LOKVESSMR4R_03159	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LOKVESSMR4R_03167	COG2925	Exonuclease
LOKVESSMR4R_03168	COG3177	Filamentation induced by cAMP protein fic
LOKVESSMR4R_03170	COG4372	Transposase
LOKVESSMR4R_03171	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_03172	COG2963	transposase activity
LOKVESSMR4R_03174	COG1940	carbohydrate kinase activity
LOKVESSMR4R_03175	COG2998	abc-type tungstate transport system, permease component
LOKVESSMR4R_03176	COG3842	ATPase activity
LOKVESSMR4R_03177	COG1177	transmembrane transport
LOKVESSMR4R_03180	COG2222	sugar isomerase
LOKVESSMR4R_03181	COG1940	carbohydrate kinase activity
LOKVESSMR4R_03182	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
LOKVESSMR4R_03183	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LOKVESSMR4R_03186	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_03193	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LOKVESSMR4R_03194	COG3842	ATPase activity
LOKVESSMR4R_03195	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_03196	COG1177	transmembrane transport
LOKVESSMR4R_03199	COG2962	Rard protein
LOKVESSMR4R_03200	COG1475	DNA binding
LOKVESSMR4R_03208	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_03210	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_03214	COG0726	polysaccharide deacetylase
LOKVESSMR4R_03219	COG0410	ABC transporter
LOKVESSMR4R_03231	COG1335	isochorismatase
LOKVESSMR4R_03232	COG2309	aminopeptidase activity
LOKVESSMR4R_03233	COG0596	Alpha beta hydrolase
LOKVESSMR4R_03234	COG3473	Maleate cis-trans isomerase
LOKVESSMR4R_03240	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_03241	COG3547	Transposase (IS116 IS110 IS902 family)
LOKVESSMR4R_03242	COG2963	transposase activity
LOKVESSMR4R_03247	COG2963	transposase activity
LOKVESSMR4R_03249	COG4372	Transposase
LOKVESSMR4R_03250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LOKVESSMR4R_03253	COG2391	methyltransferase activity
LOKVESSMR4R_03257	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_03258	COG0022	dehydrogenase e1 component
LOKVESSMR4R_03259	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LOKVESSMR4R_03260	COG0006	proline dipeptidase activity
LOKVESSMR4R_03263	COG1879	ABC-type sugar transport system periplasmic component
LOKVESSMR4R_03264	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_03265	COG4211	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_03266	COG1129	ABC transporter
LOKVESSMR4R_03274	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LOKVESSMR4R_03275	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LOKVESSMR4R_03277	COG0284	orotidine-5'-phosphate decarboxylase activity
LOKVESSMR4R_03280	COG0330	HflC and HflK could
LOKVESSMR4R_03283	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LOKVESSMR4R_03286	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LOKVESSMR4R_03289	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LOKVESSMR4R_03293	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_03294	COG0411	ABC transporter
LOKVESSMR4R_03296	COG3383	formate dehydrogenase (NAD+) activity
LOKVESSMR4R_03300	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LOKVESSMR4R_03302	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LOKVESSMR4R_03306	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LOKVESSMR4R_03307	COG1215	transferase activity, transferring glycosyl groups
LOKVESSMR4R_03308	COG1335	isochorismatase
LOKVESSMR4R_03313	COG0187	DNA topoisomerase II activity
LOKVESSMR4R_03315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LOKVESSMR4R_03316	COG0592	DNA-directed DNA polymerase activity
LOKVESSMR4R_03317	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LOKVESSMR4R_03318	COG0268	Binds directly to 16S ribosomal RNA
LOKVESSMR4R_03320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LOKVESSMR4R_03321	COG2226	methyltransferase
LOKVESSMR4R_03323	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LOKVESSMR4R_03328	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LOKVESSMR4R_03329	COG2211	Major facilitator Superfamily
LOKVESSMR4R_03330	COG0644	oxidoreductase
LOKVESSMR4R_03331	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LOKVESSMR4R_03332	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LOKVESSMR4R_03336	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKVESSMR4R_03337	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_03338	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_03341	COG0322	excinuclease ABC activity
LOKVESSMR4R_03343	COG1309	transcriptional regulator
LOKVESSMR4R_03345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LOKVESSMR4R_03345	COG0167	dihydroorotate dehydrogenase activity
LOKVESSMR4R_03346	COG0493	'glutamate synthase
LOKVESSMR4R_03349	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LOKVESSMR4R_03352	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LOKVESSMR4R_03355	COG5002	protein histidine kinase activity
LOKVESSMR4R_03355	COG2176	DNA-directed DNA polymerase activity
LOKVESSMR4R_03359	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LOKVESSMR4R_03360	COG0142	geranyltranstransferase activity
LOKVESSMR4R_03361	COG1722	exodeoxyribonuclease VII activity
LOKVESSMR4R_03362	COG0123	including yeast histone deacetylase and acetoin utilization protein
LOKVESSMR4R_03363	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_03364	COG1846	Transcriptional regulator
LOKVESSMR4R_03365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKVESSMR4R_03369	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LOKVESSMR4R_03371	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LOKVESSMR4R_03375	COG1968	undecaprenyl-diphosphatase activity
LOKVESSMR4R_03395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_03398	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOKVESSMR4R_03399	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LOKVESSMR4R_03402	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_03405	COG2610	gluconate transmembrane transporter activity
LOKVESSMR4R_03408	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKVESSMR4R_03411	COG0582	viral genome integration into host DNA
LOKVESSMR4R_03414	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_03440	COG1360	Flagellar Motor Protein
LOKVESSMR4R_03442	COG1484	DNA-dependent DNA replication
LOKVESSMR4R_03443	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LOKVESSMR4R_03447	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LOKVESSMR4R_03449	COG1987	bacterial-type flagellum assembly
LOKVESSMR4R_03461	COG1677	Flagellar hook-basal body complex protein FliE
LOKVESSMR4R_03462	COG2204	response regulator
LOKVESSMR4R_03467	COG0455	bacterial-type flagellum organization
LOKVESSMR4R_03469	COG4786	Flagellar basal body rod
LOKVESSMR4R_03475	COG4786	Flagellar basal body rod
LOKVESSMR4R_03477	COG1749	Flagellar hook protein flgE
LOKVESSMR4R_03478	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LOKVESSMR4R_03479	COG1558	bacterial-type flagellum-dependent cell motility
LOKVESSMR4R_03483	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LOKVESSMR4R_03488	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LOKVESSMR4R_03489	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LOKVESSMR4R_03492	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LOKVESSMR4R_03493	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LOKVESSMR4R_03499	COG1137	ATPase activity
LOKVESSMR4R_03500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LOKVESSMR4R_03501	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LOKVESSMR4R_03507	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LOKVESSMR4R_03508	COG1218	3'(2'),5'-bisphosphate nucleotidase
LOKVESSMR4R_03510	COG0443	Heat shock 70 kDa protein
LOKVESSMR4R_03511	COG0484	heat shock protein binding
LOKVESSMR4R_03512	COG2003	Belongs to the UPF0758 family
LOKVESSMR4R_03521	COG4372	Transposase
LOKVESSMR4R_03522	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_03523	COG2963	transposase activity
LOKVESSMR4R_03524	COG0582	viral genome integration into host DNA
LOKVESSMR4R_03526	COG0653	protein targeting
LOKVESSMR4R_03527	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKVESSMR4R_03528	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LOKVESSMR4R_03529	COG0494	nUDIX hydrolase
LOKVESSMR4R_03530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LOKVESSMR4R_03533	COG0779	Required for maturation of 30S ribosomal subunits
LOKVESSMR4R_03534	COG0747	negative chemotaxis
LOKVESSMR4R_03535	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_03537	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_03538	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_03539	COG0601	transmembrane transport
LOKVESSMR4R_03541	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LOKVESSMR4R_03543	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOKVESSMR4R_03545	COG1040	competence protein
LOKVESSMR4R_03546	COG2226	methyltransferase
LOKVESSMR4R_03550	COG3034	peptidoglycan biosynthetic process
LOKVESSMR4R_03552	COG1132	(ABC) transporter
LOKVESSMR4R_03553	COG1132	(ABC) transporter
LOKVESSMR4R_03554	COG0617	tRNA 3'-terminal CCA addition
LOKVESSMR4R_03555	COG0494	nUDIX hydrolase
LOKVESSMR4R_03556	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LOKVESSMR4R_03557	COG0494	nUDIX hydrolase
LOKVESSMR4R_03558	COG0137	argininosuccinate synthase activity
LOKVESSMR4R_03562	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_03563	COG0280	phosphate acetyltransferase
LOKVESSMR4R_03563	COG0281	malic enzyme
LOKVESSMR4R_03564	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LOKVESSMR4R_03565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LOKVESSMR4R_03567	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LOKVESSMR4R_03568	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LOKVESSMR4R_03569	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOKVESSMR4R_03570	COG1475	DNA binding
LOKVESSMR4R_03571	COG1192	Involved in chromosome partitioning
LOKVESSMR4R_03573	COG0445	tRNA wobble uridine modification
LOKVESSMR4R_03574	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LOKVESSMR4R_03575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LOKVESSMR4R_03577	COG0424	maF-like protein
LOKVESSMR4R_03578	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LOKVESSMR4R_03579	COG0237	dephospho-CoA kinase activity
LOKVESSMR4R_03580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LOKVESSMR4R_03581	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LOKVESSMR4R_03582	COG3030	protein affecting phage T7 exclusion by the F plasmid
LOKVESSMR4R_03585	COG2840	Smr protein MutS2
LOKVESSMR4R_03587	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LOKVESSMR4R_03589	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LOKVESSMR4R_03592	COG1074	ATP-dependent DNA helicase activity
LOKVESSMR4R_03594	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOKVESSMR4R_03595	COG3178	'Phosphotransferase
LOKVESSMR4R_03599	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LOKVESSMR4R_03600	COG2847	Copper chaperone PCu(A)C
LOKVESSMR4R_03604	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_03605	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_03606	COG1429	ligase activity, forming nitrogen-metal bonds
LOKVESSMR4R_03607	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LOKVESSMR4R_03610	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LOKVESSMR4R_03614	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LOKVESSMR4R_03616	COG0156	8-amino-7-oxononanoate synthase activity
LOKVESSMR4R_03619	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LOKVESSMR4R_03620	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LOKVESSMR4R_03622	COG1233	COG1233 Phytoene dehydrogenase and related
LOKVESSMR4R_03623	COG1562	ergosterol biosynthetic process
LOKVESSMR4R_03624	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LOKVESSMR4R_03625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LOKVESSMR4R_03626	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LOKVESSMR4R_03629	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LOKVESSMR4R_03631	COG4143	(ABC) transporter
LOKVESSMR4R_03632	COG1178	ABC-type Fe3 transport system permease component
LOKVESSMR4R_03633	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LOKVESSMR4R_03640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKVESSMR4R_03641	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LOKVESSMR4R_03644	COG0366	Alpha amylase catalytic
LOKVESSMR4R_03645	COG0366	Alpha amylase catalytic
LOKVESSMR4R_03646	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LOKVESSMR4R_03648	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LOKVESSMR4R_03649	COG1640	4-alpha-glucanotransferase
LOKVESSMR4R_03651	COG4372	Transposase
LOKVESSMR4R_03652	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_03653	COG2963	transposase activity
LOKVESSMR4R_03656	COG3191	aminopeptidase activity
LOKVESSMR4R_03663	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOKVESSMR4R_03669	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LOKVESSMR4R_03670	COG4134	Bacterial extracellular solute-binding protein
LOKVESSMR4R_03671	COG4135	transport system, permease component
LOKVESSMR4R_03672	COG4136	ATPase activity
LOKVESSMR4R_03674	COG5621	secreted hydrolase
LOKVESSMR4R_03675	COG1233	COG1233 Phytoene dehydrogenase and related
LOKVESSMR4R_03676	COG0142	geranyltranstransferase activity
LOKVESSMR4R_03677	COG0500	methyltransferase
LOKVESSMR4R_03679	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LOKVESSMR4R_03680	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_03681	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_03688	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LOKVESSMR4R_03689	COG1132	(ABC) transporter
LOKVESSMR4R_03712	COG0616	signal peptide processing
LOKVESSMR4R_03719	COG2801	Transposase and inactivated derivatives
LOKVESSMR4R_03734	COG3750	Belongs to the UPF0335 family
LOKVESSMR4R_03742	COG1609	Transcriptional regulator
LOKVESSMR4R_03745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LOKVESSMR4R_03746	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LOKVESSMR4R_03749	COG1194	a g-specific adenine glycosylase
LOKVESSMR4R_03751	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LOKVESSMR4R_03752	COG1663	tetraacyldisaccharide 4'-kinase activity
LOKVESSMR4R_03753	COG1519	Transferase
LOKVESSMR4R_03756	COG0312	modulator of DNA gyrase
LOKVESSMR4R_03758	COG4221	oxidoreductase activity
LOKVESSMR4R_03760	COG2081	HI0933 family
LOKVESSMR4R_03761	COG0625	glutathione transferase activity
LOKVESSMR4R_03765	COG0495	leucyl-tRNA aminoacylation
LOKVESSMR4R_03768	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LOKVESSMR4R_03769	COG0564	pseudouridine synthase activity
LOKVESSMR4R_03771	COG0346	lactoylglutathione lyase activity
LOKVESSMR4R_03773	COG0450	alkyl hydroperoxide reductase
LOKVESSMR4R_03775	COG1185	polyribonucleotide nucleotidyltransferase activity
LOKVESSMR4R_03776	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LOKVESSMR4R_03778	COG0596	Alpha beta hydrolase
LOKVESSMR4R_03780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LOKVESSMR4R_03781	COG0189	ligase activity
LOKVESSMR4R_03781	COG4067	protein conserved in archaea
LOKVESSMR4R_03782	COG0189	ligase activity
LOKVESSMR4R_03784	COG0514	ATP-dependent DNA helicase (RecQ)
LOKVESSMR4R_03791	COG2211	Major facilitator Superfamily
LOKVESSMR4R_03794	COG1595	DNA-templated transcription, initiation
LOKVESSMR4R_03795	COG3806	Anti-sigma factor
LOKVESSMR4R_03796	COG1322	Protein conserved in bacteria
LOKVESSMR4R_03797	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LOKVESSMR4R_03798	COG0612	Peptidase, M16
LOKVESSMR4R_03799	COG0612	Peptidase, M16
LOKVESSMR4R_03801	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LOKVESSMR4R_03802	COG0138	bifunctional purine biosynthesis protein purh
LOKVESSMR4R_03804	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LOKVESSMR4R_03808	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LOKVESSMR4R_03809	COG0628	permease
LOKVESSMR4R_03814	COG1376	ErfK ybiS ycfS ynhG family protein
LOKVESSMR4R_03817	COG0765	amino acid transport
LOKVESSMR4R_03819	COG2133	pyrroloquinoline quinone binding
LOKVESSMR4R_03825	COG2311	Membrane
LOKVESSMR4R_03826	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LOKVESSMR4R_03827	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LOKVESSMR4R_03827	COG0662	Cupin 2, conserved barrel domain protein
LOKVESSMR4R_03828	COG3316	Transposase and inactivated derivatives
LOKVESSMR4R_03829	COG0517	IMP dehydrogenase activity
LOKVESSMR4R_03830	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_03836	COG1192	Involved in chromosome partitioning
LOKVESSMR4R_03843	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LOKVESSMR4R_03844	COG3626	phosphonate metabolism
LOKVESSMR4R_03845	COG3627	carbon phosphorus lyase activity
LOKVESSMR4R_03846	COG4107	phosphonate C-P lyase system protein PhnK
LOKVESSMR4R_03847	COG4778	phosphonate C-P lyase system protein PhnL
LOKVESSMR4R_03871	COG4644	lycopene metabolic process
LOKVESSMR4R_03893	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_03894	COG0251	oxidation-reduction process
LOKVESSMR4R_03895	COG0579	oxidoreductase
LOKVESSMR4R_03896	COG0251	oxidation-reduction process
LOKVESSMR4R_03897	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKVESSMR4R_03898	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKVESSMR4R_03904	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LOKVESSMR4R_03910	COG1192	Involved in chromosome partitioning
LOKVESSMR4R_03914	COG3505	Type IV secretory pathway VirD4
LOKVESSMR4R_03915	COG4644	lycopene metabolic process
LOKVESSMR4R_03920	COG4227	nucleotidyltransferase activity
LOKVESSMR4R_03926	COG3609	addiction module antidote protein, CC2985 family
LOKVESSMR4R_03932	COG1475	DNA binding
LOKVESSMR4R_03935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKVESSMR4R_03936	COG1454	alcohol dehydrogenase
LOKVESSMR4R_03937	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_03940	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_03940	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_03949	COG1476	TRANSCRIPTIONal
LOKVESSMR4R_03952	COG4644	lycopene metabolic process
LOKVESSMR4R_03954	COG1196	nuclear chromosome segregation
LOKVESSMR4R_03954	COG0741	lytic transglycosylase activity
LOKVESSMR4R_03954	COG0739	heme binding
LOKVESSMR4R_03957	COG3451	type IV secretory pathway VirB4
LOKVESSMR4R_03960	COG0739	heme binding
LOKVESSMR4R_03960	COG1196	nuclear chromosome segregation
LOKVESSMR4R_03960	COG0741	lytic transglycosylase activity
LOKVESSMR4R_03964	COG3736	Type IV secretory pathway, component VirB8
LOKVESSMR4R_03965	COG3504	Conjugal transfer protein
LOKVESSMR4R_03967	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LOKVESSMR4R_03969	COG3505	Type IV secretory pathway VirD4
LOKVESSMR4R_03975	COG0556	nucleotide-excision repair
LOKVESSMR4R_03980	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_03981	COG0582	viral genome integration into host DNA
LOKVESSMR4R_03982	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_03990	COG3077	Addiction module antitoxin, RelB DinJ family
LOKVESSMR4R_03994	COG1475	DNA binding
LOKVESSMR4R_04004	COG4717	serine-type aminopeptidase activity
LOKVESSMR4R_04005	COG0420	3'-5' exonuclease activity
LOKVESSMR4R_04018	COG1475	DNA binding
LOKVESSMR4R_04019	COG1414	Transcriptional regulator
LOKVESSMR4R_04020	COG1475	DNA binding
LOKVESSMR4R_04021	COG1192	Involved in chromosome partitioning