locus-tag	class	description
AZF00_00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AZF00_00025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AZF00_00030	COG0339	signal peptide processing
AZF00_00050	COG3268	Saccharopine dehydrogenase
AZF00_00070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AZF00_00075	COG0583	DNA-binding transcription factor activity
AZF00_00085	COG0534	Mate efflux family protein
AZF00_00090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AZF00_00095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZF00_00125	COG1612	heme a metabolic process
AZF00_00130	COG0109	protoheme IX farnesyltransferase activity
AZF00_00140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AZF00_00145	COG1121	(ABC) transporter
AZF00_00150	COG0735	belongs to the Fur family
AZF00_00155	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AZF00_00170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AZF00_00200	COG0189	ligase activity
AZF00_00200	COG4067	protein conserved in archaea
AZF00_00210	COG3272	Protein of unknown function (DUF1722)
AZF00_00230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AZF00_00235	COG1917	Cupin 2, conserved barrel domain protein
AZF00_00240	COG0527	aspartate kinase activity
AZF00_00270	COG0330	HflC and HflK could
AZF00_00285	COG0204	Acyl-transferase
AZF00_00290	COG3795	YCII-related domain
AZF00_00295	COG5507	3-demethylubiquinone-9 3-methyltransferase
AZF00_00300	COG2353	YceI-like domain
AZF00_00305	COG4303	Ethanolamine ammonia lyase large subunit
AZF00_00310	COG4302	ethanolamine ammonia-lyase activity
AZF00_00315	COG3447	MASE1 domain protein
AZF00_00315	COG5002	protein histidine kinase activity
AZF00_00315	COG5001	Diguanylate cyclase
AZF00_00355	COG2124	cytochrome p450
AZF00_00360	COG2010	Cytochrome c
AZF00_00380	COG1346	cytolysis
AZF00_00390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AZF00_00395	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AZF00_00405	COG2837	iron assimilation
AZF00_00420	COG0515	serine threonine protein kinase
AZF00_00435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AZF00_00460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AZF00_00480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AZF00_00485	COG0678	peroxiredoxin activity
AZF00_00490	COG0071	Belongs to the small heat shock protein (HSP20) family
AZF00_00495	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AZF00_00515	COG2183	response to ionizing radiation
AZF00_00520	COG1309	transcriptional regulator
AZF00_00545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AZF00_00555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AZF00_00560	COG1011	Hydrolase
AZF00_00570	COG1309	transcriptional regulator
AZF00_00575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AZF00_00580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AZF00_00610	COG3264	Mechanosensitive ion channel
AZF00_00610	COG1196	nuclear chromosome segregation
AZF00_00625	COG0129	dihydroxy-acid dehydratase activity
AZF00_00635	COG2816	NAD+ diphosphatase activity
AZF00_00640	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_00645	COG5001	Diguanylate cyclase
AZF00_00645	COG4251	negative regulation of phosphorylation
AZF00_00645	COG3706	GGDEF domain
AZF00_00645	COG2203	Gaf domain
AZF00_00650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZF00_00660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AZF00_00680	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AZF00_00685	COG1519	Transferase
AZF00_00690	COG1538	Outer membrane efflux protein
AZF00_00695	COG3151	Protein conserved in bacteria
AZF00_00700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AZF00_00705	COG3150	esterase
AZF00_00725	COG0259	pyridoxamine-phosphate oxidase activity
AZF00_00760	COG0606	chelatase, subunit chli
AZF00_00785	COG0582	viral genome integration into host DNA
AZF00_00795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AZF00_00820	COG0829	nickel cation binding
AZF00_00825	COG0831	urea catabolic process
AZF00_00830	COG0832	Belongs to the urease beta subunit family
AZF00_00835	COG0804	urea catabolic process
AZF00_00840	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AZF00_00845	COG0830	nickel cation binding
AZF00_00850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AZF00_00875	COG0411	ABC transporter
AZF00_00880	COG0410	ABC transporter
AZF00_00885	COG3038	cytochrome b561
AZF00_00890	COG2353	YceI-like domain
AZF00_00895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZF00_00905	COG0412	Dienelactone hydrolase
AZF00_00920	COG0347	Belongs to the P(II) protein family
AZF00_00925	COG0004	ammonium transporteR
AZF00_00955	COG0347	Belongs to the P(II) protein family
AZF00_00970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AZF00_00985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AZF00_01000	COG1965	Belongs to the frataxin family
AZF00_01010	COG3072	Adenylate cyclase
AZF00_01020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AZF00_01025	COG0405	Gamma-glutamyltransferase
AZF00_01035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZF00_01040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AZF00_01045	COG4372	Transposase
AZF00_01060	COG3206	protein involved in exopolysaccharide biosynthesis
AZF00_01060	COG0489	protein tyrosine kinase activity
AZF00_01065	COG1596	polysaccharide export
AZF00_01090	COG0297	glycogen (starch) synthase activity
AZF00_01140	COG2226	methyltransferase
AZF00_01160	COG0438	transferase activity, transferring glycosyl groups
AZF00_01205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AZF00_01235	COG1234	tRNA 3'-trailer cleavage
AZF00_01260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AZF00_01265	COG4771	TonB-dependent receptor
AZF00_01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AZF00_01280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AZF00_01290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AZF00_01300	COG1285	pathogenesis
AZF00_01305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AZF00_01310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AZF00_01320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AZF00_01330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZF00_01335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AZF00_01345	COG0126	phosphoglycerate kinase activity
AZF00_01375	COG2885	chlorophyll binding
AZF00_01375	COG3047	cAMP biosynthetic process
AZF00_01385	COG2199	diguanylate cyclase activity
AZF00_01385	COG2200	EAL domain
AZF00_01395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZF00_01450	COG3620	sequence-specific DNA binding
AZF00_01455	COG3550	peptidyl-serine autophosphorylation
AZF00_01490	COG0582	viral genome integration into host DNA
AZF00_01505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AZF00_01510	COG1194	a g-specific adenine glycosylase
AZF00_01520	COG0131	Imidazoleglycerol-phosphate dehydratase
AZF00_01525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AZF00_01530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AZF00_01535	COG0107	imidazoleglycerol-phosphate synthase activity
AZF00_01540	COG0793	Belongs to the peptidase S41A family
AZF00_01555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AZF00_01565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AZF00_01570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AZF00_01580	COG3852	Histidine kinase
AZF00_01590	COG0174	glutamine synthetase
AZF00_01595	COG0301	tRNA thio-modification
AZF00_01595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AZF00_01610	COG0733	neurotransmitter:sodium symporter activity
AZF00_01625	COG1490	D-aminoacyl-tRNA deacylase activity
AZF00_01645	COG4771	TonB-dependent receptor
AZF00_01665	COG0543	2 iron, 2 sulfur cluster binding
AZF00_01665	COG0633	Ferredoxin
AZF00_01700	COG0596	Alpha beta hydrolase
AZF00_01705	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_01710	COG2207	Transcriptional regulator
AZF00_01715	COG0183	Belongs to the thiolase family
AZF00_01720	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_01720	COG1024	Enoyl-CoA hydratase
AZF00_01725	COG0318	PFAM AMP-dependent synthetase and ligase
AZF00_01740	COG1024	Enoyl-CoA hydratase
AZF00_01745	COG0300	oxidoreductase activity
AZF00_01750	COG0439	Biotin carboxylase
AZF00_01760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AZF00_01765	COG1960	acyl-CoA dehydrogenase activity
AZF00_01770	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_01785	COG0024	Methionine aminopeptidase
AZF00_01805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AZF00_01820	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AZF00_01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AZF00_01830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AZF00_01845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AZF00_01855	COG1047	Peptidyl-prolyl cis-trans
AZF00_01865	COG3769	mannosylglycerate metabolic process
AZF00_01870	COG1215	transferase activity, transferring glycosyl groups
AZF00_01875	COG0366	Alpha amylase catalytic
AZF00_01880	COG1960	acyl-CoA dehydrogenase activity
AZF00_01885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZF00_01895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AZF00_01900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AZF00_01905	COG1428	Deoxynucleoside kinase
AZF00_01925	COG3852	Histidine kinase
AZF00_01930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZF00_01935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AZF00_01940	COG0436	Aminotransferase
AZF00_01970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AZF00_01980	COG0038	chloride channel
AZF00_01985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AZF00_01990	COG0316	Belongs to the HesB IscA family
AZF00_01995	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AZF00_02000	COG0739	heme binding
AZF00_02005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AZF00_02035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AZF00_02035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AZF00_02070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZF00_02090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AZF00_02095	COG0081	regulation of translation
AZF00_02100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AZF00_02105	COG0222	ribosome binding
AZF00_02110	COG0085	RNA polymerase activity
AZF00_02115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZF00_02120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AZF00_02125	COG0049	tRNA binding
AZF00_02130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZF00_02135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZF00_02140	COG0051	transcription antitermination factor activity, RNA binding
AZF00_02145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AZF00_02150	COG0088	Forms part of the polypeptide exit tunnel
AZF00_02155	COG0089	rRNA binding
AZF00_02160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AZF00_02165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AZF00_02170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AZF00_02175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AZF00_02180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AZF00_02185	COG0255	Belongs to the universal ribosomal protein uL29 family
AZF00_02190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AZF00_02195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AZF00_02200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AZF00_02205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AZF00_02210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AZF00_02215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AZF00_02220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AZF00_02225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AZF00_02230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AZF00_02235	COG0200	Binds to the 23S rRNA
AZF00_02245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AZF00_02250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AZF00_02255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AZF00_02260	COG0202	RNA polymerase activity
AZF00_02265	COG0203	ribosomal protein L17
AZF00_02275	COG2814	Major facilitator Superfamily
AZF00_02280	COG0629	single-stranded DNA binding
AZF00_02290	COG0521	Mo-molybdopterin cofactor biosynthetic process
AZF00_02295	COG0303	'Molybdopterin
AZF00_02305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AZF00_02320	COG0166	Belongs to the GPI family
AZF00_02325	COG0142	geranyltranstransferase activity
AZF00_02340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AZF00_02345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AZF00_02350	COG0268	Binds directly to 16S ribosomal RNA
AZF00_02355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AZF00_02360	COG1560	Kdo2-lipid A biosynthetic process
AZF00_02430	COG1216	Glycosyl transferase, family 2
AZF00_02455	COG0659	secondary active sulfate transmembrane transporter activity
AZF00_02460	COG0589	response to stress
AZF00_02470	COG1309	transcriptional regulator
AZF00_02475	COG1937	Protein conserved in bacteria
AZF00_02480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AZF00_02490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZF00_02495	COG2814	Major facilitator Superfamily
AZF00_02505	COG2124	cytochrome p450
AZF00_02525	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_02550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZF00_02605	COG2072	flavoprotein involved in K transport
AZF00_02610	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_02635	COG0183	Belongs to the thiolase family
AZF00_02640	COG1024	Enoyl-CoA hydratase
AZF00_02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_02645	COG1960	acyl-CoA dehydrogenase activity
AZF00_02650	COG1024	Enoyl-CoA hydratase
AZF00_02655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZF00_02670	COG0582	viral genome integration into host DNA
AZF00_02775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AZF00_02785	COG0183	Belongs to the thiolase family
AZF00_02795	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_02825	COG4447	cellulose binding
AZF00_02845	COG1024	Enoyl-CoA hydratase
AZF00_02845	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_02850	COG2030	dehydratase
AZF00_02850	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_02855	COG1024	Enoyl-CoA hydratase
AZF00_02860	COG0183	Belongs to the thiolase family
AZF00_02865	COG3396	Phenylacetate-CoA oxygenase
AZF00_02870	COG3460	Phenylacetate-CoA oxygenase
AZF00_02875	COG3396	Phenylacetate-CoA oxygenase
AZF00_02880	COG2151	metal-sulfur cluster biosynthetic enzyme
AZF00_02885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AZF00_02890	COG2050	protein possibly involved in aromatic compounds catabolism
AZF00_02895	COG1959	2 iron, 2 sulfur cluster binding
AZF00_02910	COG2226	methyltransferase
AZF00_02920	COG1773	rubredoxin
AZF00_02945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AZF00_02950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AZF00_02975	COG0582	viral genome integration into host DNA
AZF00_03000	COG0210	DNA helicase
AZF00_03045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AZF00_03115	COG2963	transposase activity
AZF00_03120	COG0419	ATPase involved in DNA repair
AZF00_03130	COG4974	Belongs to the 'phage' integrase family
AZF00_03195	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AZF00_03195	COG3264	Mechanosensitive ion channel
AZF00_03220	COG3384	dioxygenase
AZF00_03245	COG3540	Alkaline phosphatase
AZF00_03275	COG3586	endonuclease activity
AZF00_03285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AZF00_03295	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AZF00_03335	COG0248	Ppx GppA phosphatase
AZF00_03340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF00_03355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AZF00_03365	COG2867	negative regulation of translational initiation
AZF00_03370	COG2914	Belongs to the UPF0125 (RnfH) family
AZF00_03385	COG0497	DNA recombination
AZF00_03390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AZF00_03395	COG0443	Heat shock 70 kDa protein
AZF00_03400	COG0484	heat shock protein binding
AZF00_03405	COG1295	ribonuclease BN
AZF00_03405	COG1959	2 iron, 2 sulfur cluster binding
AZF00_03410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AZF00_03415	COG0505	Belongs to the CarA family
AZF00_03420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZF00_03435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AZF00_03445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AZF00_03450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AZF00_03470	COG0779	Required for maturation of 30S ribosomal subunits
AZF00_03475	COG0195	Participates in both transcription termination and antitermination
AZF00_03475	COG2251	uridine kinase activity
AZF00_03480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AZF00_03485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AZF00_03490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AZF00_03495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AZF00_03500	COG1185	polyribonucleotide nucleotidyltransferase activity
AZF00_03515	COG1073	alpha beta
AZF00_03520	COG1047	Peptidyl-prolyl cis-trans
AZF00_03545	COG0560	Phosphoserine phosphatase
AZF00_03545	COG3830	Belongs to the UPF0237 family
AZF00_03560	COG1509	lysine 2,3-aminomutase activity
AZF00_03565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AZF00_03570	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AZF00_03585	COG1162	GTPase activity
AZF00_03590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AZF00_03595	COG3240	lipase activity
AZF00_03595	COG4625	pathogenesis
AZF00_03610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AZF00_03610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AZF00_03615	COG0802	atpase or kinase
AZF00_03620	COG0860	N-Acetylmuramoyl-L-alanine amidase
AZF00_03625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZF00_03630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AZF00_03635	COG1923	regulation of RNA biosynthetic process
AZF00_03640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AZF00_03645	COG0330	HflC and HflK could
AZF00_03650	COG0330	HflC and HflK could
AZF00_03660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AZF00_03695	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_03715	COG1764	response to oxidative stress
AZF00_03725	COG0318	PFAM AMP-dependent synthetase and ligase
AZF00_03740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AZF00_03760	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_03770	COG0183	Belongs to the thiolase family
AZF00_03775	COG0427	acetyl-CoA hydrolase
AZF00_03795	COG4771	TonB-dependent receptor
AZF00_03815	COG0633	Ferredoxin
AZF00_03820	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AZF00_03840	COG1846	Transcriptional regulator
AZF00_03850	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_03860	COG2267	carboxylic ester hydrolase activity
AZF00_03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZF00_03910	COG1845	cytochrome c oxidase, subunit III
AZF00_03930	COG0243	molybdopterin cofactor binding
AZF00_03940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZF00_03940	COG0493	'glutamate synthase
AZF00_03975	COG0183	Belongs to the thiolase family
AZF00_03985	COG1024	Enoyl-CoA hydratase
AZF00_03990	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_04000	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_04025	COG1960	acyl-CoA dehydrogenase activity
AZF00_04030	COG0583	DNA-binding transcription factor activity
AZF00_04035	COG1024	Enoyl-CoA hydratase
AZF00_04035	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_04040	COG1960	acyl-CoA dehydrogenase activity
AZF00_04050	COG2937	Belongs to the GPAT DAPAT family
AZF00_04055	COG2267	carboxylic ester hydrolase activity
AZF00_04080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AZF00_04090	COG4771	TonB-dependent receptor
AZF00_04100	COG1024	Enoyl-CoA hydratase
AZF00_04115	COG0280	phosphate acetyltransferase
AZF00_04130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZF00_04135	COG0183	Belongs to the thiolase family
AZF00_04140	COG2366	antibiotic biosynthetic process
AZF00_04180	COG0557	exoribonuclease II activity
AZF00_04185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZF00_04190	COG0360	Binds together with S18 to 16S ribosomal RNA
AZF00_04195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AZF00_04205	COG0359	binds to the 23S rRNA
AZF00_04210	COG0305	Participates in initiation and elongation during chromosome replication
AZF00_04235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AZF00_04240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZF00_04250	COG2226	methyltransferase
AZF00_04265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AZF00_04305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AZF00_04310	COG0067	glutamate synthase
AZF00_04310	COG0070	glutamate synthase
AZF00_04310	COG0069	glutamate synthase activity
AZF00_04315	COG0493	'glutamate synthase
AZF00_04340	COG0519	Catalyzes the synthesis of GMP from XMP
AZF00_04345	COG4783	chaperone-mediated protein folding
AZF00_04350	COG1045	serine acetyltransferase
AZF00_04355	COG0110	maltose O-acetyltransferase activity
AZF00_04370	COG1131	(ABC) transporter
AZF00_04375	COG0842	Transport permease protein
AZF00_04380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZF00_04400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AZF00_04415	COG1040	competence protein
AZF00_04425	COG0156	8-amino-7-oxononanoate synthase activity
AZF00_04450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AZF00_04455	COG1960	acyl-CoA dehydrogenase activity
AZF00_04460	COG1960	acyl-CoA dehydrogenase activity
AZF00_04495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AZF00_04500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZF00_04515	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_04520	COG1960	acyl-CoA dehydrogenase activity
AZF00_04525	COG1024	Enoyl-CoA hydratase
AZF00_04540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AZF00_04550	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_04555	COG2766	serine protein kinase
AZF00_04560	COG2718	Belongs to the UPF0229 family
AZF00_04565	COG2719	SpoVR family
AZF00_04570	COG1024	Enoyl-CoA hydratase
AZF00_04590	COG0745	RESPONSE REGULATOR receiver
AZF00_04590	COG3706	GGDEF domain
AZF00_04600	COG0564	pseudouridine synthase activity
AZF00_04610	COG2124	cytochrome p450
AZF00_04615	COG4191	Histidine kinase
AZF00_04655	COG1024	Enoyl-CoA hydratase
AZF00_04660	COG1309	transcriptional regulator
AZF00_04665	COG0210	DNA helicase
AZF00_04680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AZF00_04720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZF00_04730	COG1214	PFAM Peptidase M22, glycoprotease
AZF00_04730	COG0456	acetyltransferase
AZF00_04740	COG1686	Belongs to the peptidase S11 family
AZF00_04780	COG4372	Transposase
AZF00_04785	COG3436	PFAM IS66 Orf2 family protein
AZF00_04795	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AZF00_04800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AZF00_04805	COG0235	Class ii aldolase
AZF00_04810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AZF00_04830	COG1704	LemA family
AZF00_04835	COG2124	cytochrome p450
AZF00_04840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZF00_04850	COG1595	DNA-templated transcription, initiation
AZF00_04860	COG4771	TonB-dependent receptor
AZF00_04870	COG0745	RESPONSE REGULATOR receiver
AZF00_04870	COG3706	GGDEF domain
AZF00_04880	COG0730	response to heat
AZF00_04900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AZF00_04905	COG0134	indole-3-glycerol-phosphate synthase activity
AZF00_04915	COG1765	OsmC-like protein
AZF00_04925	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AZF00_04930	COG5002	protein histidine kinase activity
AZF00_04930	COG2205	protein histidine kinase activity
AZF00_04930	COG0784	Response regulator, receiver
AZF00_04935	COG0151	Belongs to the GarS family
AZF00_04940	COG0138	bifunctional purine biosynthesis protein purh
AZF00_04960	COG2264	protein methyltransferase activity
AZF00_04970	COG0511	ligase activity, forming carbon-carbon bonds
AZF00_04975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AZF00_05000	COG3118	belongs to the thioredoxin family
AZF00_05005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AZF00_05010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AZF00_05015	COG1119	ATPase activity
AZF00_05025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AZF00_05035	COG4651	solute:proton antiporter activity
AZF00_05035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AZF00_05065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AZF00_05075	COG4807	Protein conserved in bacteria
AZF00_05080	COG4660	Part of a membrane complex involved in electron transport
AZF00_05085	COG4659	FMN binding
AZF00_05090	COG4658	electron transport chain
AZF00_05100	COG2878	Part of a membrane complex involved in electron transport
AZF00_05105	COG4657	Part of a membrane complex involved in electron transport
AZF00_05110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZF00_05110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZF00_05115	COG0489	protein tyrosine kinase activity
AZF00_05120	COG0717	Belongs to the dCTP deaminase family
AZF00_05130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AZF00_05135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AZF00_05145	COG0628	permease
AZF00_05155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AZF00_05155	COG2885	chlorophyll binding
AZF00_05160	COG0243	molybdopterin cofactor binding
AZF00_05165	COG0437	4 iron, 4 sulfur cluster binding
AZF00_05170	COG0519	Catalyzes the synthesis of GMP from XMP
AZF00_05175	COG1053	succinate dehydrogenase
AZF00_05190	COG2201	protein-glutamate methylesterase activity
AZF00_05195	COG4251	negative regulation of phosphorylation
AZF00_05200	COG1053	succinate dehydrogenase
AZF00_05200	COG3976	FMN-binding domain protein
AZF00_05205	COG4771	TonB-dependent receptor
AZF00_05210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AZF00_05225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZF00_05230	COG0686	Belongs to the AlaDH PNT family
AZF00_05270	COG0281	malic enzyme
AZF00_05290	COG1024	Enoyl-CoA hydratase
AZF00_05295	COG1960	acyl-CoA dehydrogenase activity
AZF00_05305	COG0183	Belongs to the thiolase family
AZF00_05325	COG1960	acyl-CoA dehydrogenase activity
AZF00_05335	COG0183	Belongs to the thiolase family
AZF00_05375	COG1451	nucleotide metabolic process
AZF00_05380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AZF00_05385	COG2937	Belongs to the GPAT DAPAT family
AZF00_05390	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AZF00_05395	COG4771	TonB-dependent receptor
AZF00_05400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AZF00_05410	COG1797	cobyrinic acid a,c-diamide synthase activity
AZF00_05420	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AZF00_05475	COG4251	negative regulation of phosphorylation
AZF00_05480	COG2201	protein-glutamate methylesterase activity
AZF00_05520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZF00_05545	COG2207	Transcriptional regulator
AZF00_05545	COG4753	response regulator
AZF00_05550	COG1793	dna ligase
AZF00_05560	COG2200	EAL domain
AZF00_05565	COG1742	UPF0060 membrane protein
AZF00_05580	COG0442	prolyl-tRNA aminoacylation
AZF00_05600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AZF00_05605	COG0217	transcriptional regulatory protein
AZF00_05610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AZF00_05615	COG0632	four-way junction helicase activity
AZF00_05620	COG2255	four-way junction helicase activity
AZF00_05625	COG0824	Thioesterase
AZF00_05645	COG0823	Involved in the tonB-independent uptake of proteins
AZF00_05650	COG2885	chlorophyll binding
AZF00_05655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AZF00_05660	COG0602	queuosine metabolic process
AZF00_05665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AZF00_05680	COG0129	dihydroxy-acid dehydratase activity
AZF00_05685	COG4206	TonB-dependent receptor
AZF00_05700	COG0183	Belongs to the thiolase family
AZF00_05705	COG1960	acyl-CoA dehydrogenase activity
AZF00_05710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AZF00_05715	COG0300	oxidoreductase activity
AZF00_05750	COG4771	TonB-dependent receptor
AZF00_05760	COG3530	Putative quorum-sensing-regulated virulence factor
AZF00_05765	COG1309	transcriptional regulator
AZF00_05785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AZF00_05800	COG1024	Enoyl-CoA hydratase
AZF00_05815	COG2070	2-Nitropropane dioxygenase
AZF00_05820	COG1917	Cupin 2, conserved barrel domain protein
AZF00_05820	COG2207	Transcriptional regulator
AZF00_05845	COG0800	Aldolase
AZF00_05850	COG0363	glucosamine-6-phosphate deaminase activity
AZF00_05855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AZF00_05885	COG1558	bacterial-type flagellum-dependent cell motility
AZF00_05890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AZF00_05895	COG1749	Flagellar hook protein flgE
AZF00_05905	COG4786	Flagellar basal body rod
AZF00_05910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AZF00_05915	COG1706	bacterial-type flagellum-dependent cell motility
AZF00_05925	COG1256	bacterial-type flagellum assembly
AZF00_05930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AZF00_05945	COG0455	bacterial-type flagellum organization
AZF00_05960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZF00_05965	COG1522	sequence-specific DNA binding
AZF00_05990	COG1252	NADH dehydrogenase
AZF00_05995	COG1902	pentaerythritol trinitrate reductase activity
AZF00_06010	COG1960	acyl-CoA dehydrogenase activity
AZF00_06025	COG0004	ammonium transporteR
AZF00_06035	COG0183	Belongs to the thiolase family
AZF00_06040	COG0183	Belongs to the thiolase family
AZF00_06060	COG4771	TonB-dependent receptor
AZF00_06095	COG1960	acyl-CoA dehydrogenase activity
AZF00_06100	COG1960	acyl-CoA dehydrogenase activity
AZF00_06115	COG1960	acyl-CoA dehydrogenase activity
AZF00_06120	COG1960	acyl-CoA dehydrogenase activity
AZF00_06125	COG1960	acyl-CoA dehydrogenase activity
AZF00_06170	COG0006	proline dipeptidase activity
AZF00_06175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AZF00_06180	COG1473	amidohydrolase
AZF00_06190	COG0366	Alpha amylase catalytic
AZF00_06195	COG0346	lactoylglutathione lyase activity
AZF00_06215	COG4774	siderophore transport
AZF00_06225	COG2814	Major facilitator Superfamily
AZF00_06230	COG1566	PFAM secretion protein HlyD family protein
AZF00_06245	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_06265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AZF00_06270	COG2885	chlorophyll binding
AZF00_06270	COG3047	cAMP biosynthetic process
AZF00_06280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZF00_06280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZF00_06295	COG1573	uracil-dna glycosylase
AZF00_06300	COG0494	nUDIX hydrolase
AZF00_06325	COG2835	tetraacyldisaccharide 4'-kinase activity
AZF00_06330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AZF00_06335	COG0527	aspartate kinase activity
AZF00_06340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AZF00_06350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZF00_06355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZF00_06360	COG3123	guanosine phosphorylase activity
AZF00_06375	COG0456	acetyltransferase
AZF00_06445	COG0596	Alpha beta hydrolase
AZF00_06450	COG1960	acyl-CoA dehydrogenase activity
AZF00_06460	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_06465	COG0183	Belongs to the thiolase family
AZF00_06470	COG0587	DNA-directed DNA polymerase activity
AZF00_06475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AZF00_06500	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_06505	COG0546	phosphoglycolate phosphatase activity
AZF00_06515	COG0402	S-adenosylhomocysteine deaminase activity
AZF00_06525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AZF00_06535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZF00_06545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AZF00_06550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AZF00_06560	COG0776	regulation of translation
AZF00_06570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AZF00_06575	COG0284	orotidine-5'-phosphate decarboxylase activity
AZF00_06585	COG0471	metal ion transport
AZF00_06585	COG3273	potassium ion transport
AZF00_06600	COG0586	Pfam SNARE associated Golgi protein
AZF00_06610	COG0582	viral genome integration into host DNA
AZF00_06620	COG0556	nucleotide-excision repair
AZF00_06645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AZF00_06655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AZF00_06660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AZF00_06665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AZF00_06675	COG0776	regulation of translation
AZF00_06705	COG2365	Tyrosine phosphatase family
AZF00_06710	COG4191	Histidine kinase
AZF00_06725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AZF00_06735	COG0386	Belongs to the glutathione peroxidase family
AZF00_06740	COG1846	Transcriptional regulator
AZF00_06745	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AZF00_06750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AZF00_06755	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AZF00_06760	COG4191	Histidine kinase
AZF00_06760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZF00_06790	COG2207	Transcriptional regulator
AZF00_06790	COG1609	Transcriptional regulator
AZF00_06810	COG0778	Nitroreductase
AZF00_06815	COG1024	Enoyl-CoA hydratase
AZF00_06835	COG1454	alcohol dehydrogenase
AZF00_06840	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AZF00_06850	COG0720	synthase
AZF00_06890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AZF00_06900	COG3139	Protein of unknown function (DUF1315)
AZF00_06910	COG0308	aminopeptidase N
AZF00_06915	COG0175	sulfate reduction
AZF00_06920	COG0167	dihydroorotate dehydrogenase activity
AZF00_06925	COG2095	MarC family integral membrane protein
AZF00_06940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZF00_06940	COG4191	Histidine kinase
AZF00_06945	COG3437	response regulator, receiver
AZF00_06945	COG0784	Response regulator, receiver
AZF00_06950	COG4251	negative regulation of phosphorylation
AZF00_06955	COG5001	Diguanylate cyclase
AZF00_06955	COG5002	protein histidine kinase activity
AZF00_06980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AZF00_07005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AZF00_07010	COG1459	type II secretion system
AZF00_07025	COG2165	general secretion pathway protein
AZF00_07055	COG1960	acyl-CoA dehydrogenase activity
AZF00_07060	COG1960	acyl-CoA dehydrogenase activity
AZF00_07065	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_07070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AZF00_07075	COG3300	MHYT domain
AZF00_07075	COG5001	Diguanylate cyclase
AZF00_07105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AZF00_07180	COG3086	response to oxidative stress
AZF00_07185	COG0481	GTPase activity
AZF00_07200	COG0571	ribonuclease III activity
AZF00_07205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AZF00_07215	COG0784	Response regulator, receiver
AZF00_07215	COG2205	protein histidine kinase activity
AZF00_07215	COG5002	protein histidine kinase activity
AZF00_07225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZF00_07230	COG3956	TIGRFAM MazG family protein
AZF00_07240	COG0563	adenylate kinase activity
AZF00_07245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AZF00_07255	COG0746	molybdenum cofactor guanylyltransferase activity
AZF00_07260	COG1214	PFAM Peptidase M22, glycoprotease
AZF00_07265	COG1968	undecaprenyl-diphosphatase activity
AZF00_07270	COG2084	Dehydrogenase
AZF00_07275	COG1362	aminopeptidase activity
AZF00_07280	COG1024	Enoyl-CoA hydratase
AZF00_07295	COG4206	TonB-dependent receptor
AZF00_07330	COG0343	queuine tRNA-ribosyltransferase activity
AZF00_07350	COG4536	flavin adenine dinucleotide binding
AZF00_07360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AZF00_07365	COG0228	four-way junction DNA binding
AZF00_07370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AZF00_07375	COG0336	Belongs to the RNA methyltransferase TrmD family
AZF00_07380	COG0335	large ribosomal subunit rRNA binding
AZF00_07390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AZF00_07395	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AZF00_07410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AZF00_07420	COG0504	CTP synthase activity
AZF00_07425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AZF00_07430	COG0148	phosphopyruvate hydratase activity
AZF00_07435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AZF00_07440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AZF00_07445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AZF00_07450	COG0585	pseudouridine synthase activity
AZF00_07455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZF00_07475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AZF00_07490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AZF00_07530	COG4964	Belongs to the GSP D family
AZF00_07555	COG2137	regulation of response to DNA damage stimulus
AZF00_07575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AZF00_07575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZF00_07580	COG4166	transmembrane transport
AZF00_07585	COG0601	transmembrane transport
AZF00_07590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZF00_07595	COG0444	Belongs to the ABC transporter superfamily
AZF00_07600	COG4608	Belongs to the ABC transporter superfamily
AZF00_07610	COG0318	PFAM AMP-dependent synthetase and ligase
AZF00_07615	COG1643	Atp-dependent helicase
AZF00_07625	COG3220	belongs to the UPF0276 family
AZF00_07635	COG2853	Lipoprotein
AZF00_07660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AZF00_07665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZF00_07695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AZF00_07700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AZF00_07705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AZF00_07715	COG3100	YcgL domain-containing protein
AZF00_07720	COG2983	Belongs to the UPF0260 family
AZF00_07730	COG1131	(ABC) transporter
AZF00_07730	COG0842	Transport permease protein
AZF00_07730	COG1716	ATPase activity
AZF00_07750	COG0515	serine threonine protein kinase
AZF00_07750	COG2815	serine threonine protein kinase
AZF00_07755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZF00_07775	COG0004	ammonium transporteR
AZF00_07785	COG0633	Ferredoxin
AZF00_07785	COG3217	Mosc domain protein beta barrel domain protein
AZF00_07800	COG0589	response to stress
AZF00_07835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZF00_07845	COG0668	transmembrane transport
AZF00_07860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AZF00_07875	COG1805	sodium ion transport
AZF00_07890	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AZF00_07900	COG1477	protein flavinylation
AZF00_07910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AZF00_07910	COG1605	Chorismate mutase
AZF00_07940	COG0811	peptide transport
AZF00_07945	COG0848	biopolymer transport protein
AZF00_07950	COG1132	(ABC) transporter
AZF00_07955	COG1663	tetraacyldisaccharide 4'-kinase activity
AZF00_07965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZF00_07970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AZF00_07985	COG0322	excinuclease ABC activity
AZF00_08025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZF00_08030	COG0315	cyclic pyranopterin monophosphate synthase activity
AZF00_08035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AZF00_08040	COG0314	molybdopterin synthase activity
AZF00_08045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZF00_08065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AZF00_08070	COG3339	Conserved Protein
AZF00_08085	COG0708	Exodeoxyribonuclease III
AZF00_08090	COG1862	Preprotein translocase
AZF00_08095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AZF00_08100	COG1115	amino acid carrier protein
AZF00_08105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AZF00_08120	COG0583	DNA-binding transcription factor activity
AZF00_08135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AZF00_08140	COG0439	Biotin carboxylase
AZF00_08155	COG1703	isobutyryl-CoA mutase activity
AZF00_08170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AZF00_08180	COG2354	Protein conserved in bacteria
AZF00_08200	COG4221	oxidoreductase activity
AZF00_08215	COG2072	flavoprotein involved in K transport
AZF00_08230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZF00_08240	COG1024	Enoyl-CoA hydratase
AZF00_08245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZF00_08250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZF00_08280	COG2850	peptidyl-arginine hydroxylation
AZF00_08290	COG2915	High frequency lysogenization protein hflD homolog
AZF00_08305	COG1187	pseudouridine synthase activity
AZF00_08315	COG1278	Cold shock
AZF00_08320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AZF00_08325	COG0542	response to heat
AZF00_08330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AZF00_08335	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AZF00_08340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AZF00_08345	COG0492	ferredoxin-NADP+ reductase activity
AZF00_08350	COG1674	ftsk spoiiie
AZF00_08355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AZF00_08360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AZF00_08365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AZF00_08370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AZF00_08375	COG1648	precorrin-2 dehydrogenase activity
AZF00_08375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AZF00_08395	COG0318	PFAM AMP-dependent synthetase and ligase
AZF00_08420	COG2853	Lipoprotein
AZF00_08460	COG2217	Heavy metal translocating P-type atpase
AZF00_08465	COG2217	Heavy metal translocating P-type atpase
AZF00_08475	COG4208	sulfate ABC transporter
AZF00_08480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AZF00_08485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AZF00_08490	COG3604	Transcriptional regulator
AZF00_08545	COG1979	alcohol dehydrogenase
AZF00_08575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZF00_08580	COG2032	superoxide dismutase activity
AZF00_08635	COG0789	Transcriptional regulator
AZF00_08660	COG1230	cation diffusion facilitator family transporter
AZF00_08665	COG1742	UPF0060 membrane protein
AZF00_08740	COG2132	Multicopper oxidase
AZF00_08745	COG0745	RESPONSE REGULATOR receiver
AZF00_08780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZF00_08805	COG0726	polysaccharide deacetylase
AZF00_08815	COG0745	RESPONSE REGULATOR receiver
AZF00_08820	COG0642	Histidine kinase
AZF00_08825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AZF00_08880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZF00_08945	COG5002	protein histidine kinase activity
AZF00_08950	COG0745	RESPONSE REGULATOR receiver
AZF00_08980	COG0789	Transcriptional regulator
AZF00_09075	COG0210	DNA helicase
AZF00_09100	COG1484	DNA-dependent DNA replication
AZF00_09105	COG4584	PFAM Integrase catalytic
AZF00_09140	COG1320	monovalent cation:proton antiporter activity
AZF00_09150	COG1006	Multisubunit Na H antiporter MnhC subunit
AZF00_09155	COG0651	ATP synthesis coupled electron transport
AZF00_09160	COG0651	ATP synthesis coupled electron transport
AZF00_09170	COG0651	ATP synthesis coupled electron transport
AZF00_09180	COG0616	signal peptide processing
AZF00_09195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZF00_09200	COG0328	RNA-DNA hybrid ribonuclease activity
AZF00_09205	COG2226	methyltransferase
AZF00_09210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZF00_09215	COG1388	LysM domain
AZF00_09215	COG0741	lytic transglycosylase activity
AZF00_09220	COG4174	ABC transporter (Permease)
AZF00_09225	COG4239	(ABC) transporter, permease
AZF00_09230	COG4166	transmembrane transport
AZF00_09235	COG0444	Belongs to the ABC transporter superfamily
AZF00_09240	COG4608	Belongs to the ABC transporter superfamily
AZF00_09245	COG2207	Transcriptional regulator
AZF00_09245	COG4753	response regulator
AZF00_09250	COG2365	Tyrosine phosphatase family
AZF00_09255	COG2813	Specifically methylates the guanine in position
AZF00_09260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZF00_09265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AZF00_09275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AZF00_09280	COG3568	Endonuclease Exonuclease Phosphatase
AZF00_09295	COG0316	Belongs to the HesB IscA family
AZF00_09295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AZF00_09330	COG2197	response regulator
AZF00_09335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZF00_09370	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_09395	COG1484	DNA-dependent DNA replication
AZF00_09400	COG4584	PFAM Integrase catalytic
AZF00_09420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZF00_09425	COG2091	lysine biosynthetic process via aminoadipic acid
AZF00_09430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZF00_09440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AZF00_09445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AZF00_09450	COG0740	serine-type endopeptidase activity
AZF00_09455	COG0544	peptidyl-prolyl cis-trans isomerase activity
AZF00_09465	COG0183	Belongs to the thiolase family
AZF00_09470	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_09470	COG1024	Enoyl-CoA hydratase
AZF00_09475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AZF00_09480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AZF00_09485	COG0084	hydrolase, TatD family'
AZF00_09500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AZF00_09505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AZF00_09510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AZF00_09515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AZF00_09520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZF00_09530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AZF00_09535	COG0416	fatty acid biosynthetic process
AZF00_09540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AZF00_09550	COG0424	maF-like protein
AZF00_09555	COG0546	phosphoglycolate phosphatase activity
AZF00_09565	COG1530	ribonuclease E activity
AZF00_09575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AZF00_09580	COG0670	Belongs to the BI1 family
AZF00_09585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AZF00_09600	COG2920	part of a sulfur-relay system
AZF00_09605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AZF00_09610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AZF00_09615	COG2154	pterin-4-alpha-carbinolamine dehydratase
AZF00_09645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AZF00_09645	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AZF00_09650	COG0842	Transport permease protein
AZF00_09655	COG1131	(ABC) transporter
AZF00_09680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZF00_09685	COG0436	Aminotransferase
AZF00_09690	COG0116	Belongs to the methyltransferase superfamily
AZF00_09690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AZF00_09700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZF00_09705	COG3101	peptidyl-lysine hydroxylation
AZF00_09725	COG3089	Belongs to the UPF0270 family
AZF00_09735	COG0011	TIGRFAM Protein of
AZF00_09755	COG2814	Major facilitator Superfamily
AZF00_09760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AZF00_09770	COG0302	gtp cyclohydrolase
AZF00_09785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AZF00_09790	COG0326	Molecular chaperone. Has ATPase activity
AZF00_09795	COG1960	acyl-CoA dehydrogenase activity
AZF00_09810	COG0045	succinate-CoA ligase (ADP-forming) activity
AZF00_09830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AZF00_09835	COG1053	succinate dehydrogenase
AZF00_09840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AZF00_09895	COG1444	tRNA N-acetyltransferase activity
AZF00_09910	COG0564	pseudouridine synthase activity
AZF00_09920	COG2814	Major facilitator Superfamily
AZF00_09930	COG0704	Plays a role in the regulation of phosphate uptake
AZF00_09940	COG0581	inorganic phosphate transmembrane transporter activity
AZF00_09965	COG0788	formyltetrahydrofolate deformylase activity
AZF00_09985	COG1278	Cold shock
AZF00_09990	COG0116	Belongs to the methyltransferase superfamily
AZF00_09990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AZF00_09995	COG3130	regulation of translation
AZF00_10005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AZF00_10015	COG0009	L-threonylcarbamoyladenylate synthase
AZF00_10020	COG0613	PHP domain protein
AZF00_10030	COG2350	Protein conserved in bacteria
AZF00_10040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AZF00_10095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AZF00_10110	COG0215	cysteine-tRNA ligase activity
AZF00_10115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZF00_10120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AZF00_10125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZF00_10130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZF00_10130	COG1116	anion transmembrane transporter activity
AZF00_10135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZF00_10140	COG1116	anion transmembrane transporter activity
AZF00_10145	COG1116	anion transmembrane transporter activity
AZF00_10145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZF00_10175	COG0590	tRNA wobble adenosine to inosine editing
AZF00_10180	COG3264	Mechanosensitive ion channel
AZF00_10180	COG1511	domain protein
AZF00_10195	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AZF00_10235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AZF00_10235	COG0519	Catalyzes the synthesis of GMP from XMP
AZF00_10245	COG1570	exodeoxyribonuclease VII activity
AZF00_10250	COG1309	transcriptional regulator
AZF00_10260	COG4584	PFAM Integrase catalytic
AZF00_10265	COG1484	DNA-dependent DNA replication
AZF00_10270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZF00_10275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AZF00_10300	COG0183	Belongs to the thiolase family
AZF00_10305	COG1024	Enoyl-CoA hydratase
AZF00_10320	COG1960	acyl-CoA dehydrogenase activity
AZF00_10325	COG2974	May be involved in recombination
AZF00_10360	COG0596	Alpha beta hydrolase
AZF00_10375	COG0537	adenosine 5'-monophosphoramidase activity
AZF00_10415	COG0252	asparaginase activity
AZF00_10435	COG0640	Transcriptional regulator
AZF00_10445	COG0798	PFAM Bile acid sodium symporter
AZF00_10485	COG0714	Associated with various cellular activities
AZF00_10500	COG1286	toxin biosynthetic process
AZF00_10510	COG0285	dihydrofolate synthase activity
AZF00_10515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AZF00_10520	COG0159	tryptophan synthase activity
AZF00_10525	COG0133	tryptophan synthase activity
AZF00_10530	COG0135	phosphoribosylanthranilate isomerase activity
AZF00_10545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AZF00_10555	COG0473	3-isopropylmalate dehydrogenase activity
AZF00_10560	COG0066	3-isopropylmalate dehydratase activity
AZF00_10565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AZF00_10575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AZF00_10600	COG0346	lactoylglutathione lyase activity
AZF00_10610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AZF00_10615	COG3115	cell septum assembly
AZF00_10620	COG1196	nuclear chromosome segregation
AZF00_10640	COG1138	Cytochrome C-type biogenesis protein
AZF00_10645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AZF00_10660	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZF00_10665	COG4133	protoheme IX ABC transporter activity
AZF00_10680	COG0455	bacterial-type flagellum organization
AZF00_10715	COG0037	tRNA processing
AZF00_10720	COG0039	L-malate dehydrogenase activity
AZF00_10750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AZF00_10760	COG2205	protein histidine kinase activity
AZF00_10770	COG2204	response regulator
AZF00_10785	COG0745	RESPONSE REGULATOR receiver
AZF00_10795	COG0729	surface antigen
AZF00_10805	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_10815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AZF00_10820	COG4181	ATPase activity
AZF00_10855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AZF00_10855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AZF00_10860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZF00_10875	COG2205	protein histidine kinase activity
AZF00_10885	COG2204	response regulator
AZF00_10895	COG2272	Belongs to the type-B carboxylesterase lipase family
AZF00_10915	COG0432	Pfam Uncharacterised protein family UPF0047
AZF00_10945	COG0596	Alpha beta hydrolase
AZF00_10975	COG0435	Glutathione S-transferase
AZF00_10990	COG0745	RESPONSE REGULATOR receiver
AZF00_10995	COG2205	protein histidine kinase activity
AZF00_11055	COG2132	Multicopper oxidase
AZF00_11085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AZF00_11110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AZF00_11125	COG1024	Enoyl-CoA hydratase
AZF00_11125	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_11130	COG0183	Belongs to the thiolase family
AZF00_11145	COG5002	protein histidine kinase activity
AZF00_11150	COG0745	RESPONSE REGULATOR receiver
AZF00_11165	COG0795	lipopolysaccharide-transporting ATPase activity
AZF00_11170	COG0795	lipopolysaccharide-transporting ATPase activity
AZF00_11175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AZF00_11190	COG0525	valine-tRNA ligase activity
AZF00_11215	COG0023	Translation Initiation Factor
AZF00_11220	COG2204	response regulator
AZF00_11225	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AZF00_11235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZF00_11235	COG4191	Histidine kinase
AZF00_11260	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_11300	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZF00_11300	COG1024	Enoyl-CoA hydratase
AZF00_11305	COG0183	Belongs to the thiolase family
AZF00_11330	COG3122	Protein conserved in bacteria
AZF00_11335	COG0514	ATP-dependent DNA helicase (RecQ)
AZF00_11345	COG0217	transcriptional regulatory protein
AZF00_11355	COG2066	Belongs to the glutaminase family
AZF00_11360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AZF00_11370	COG1999	signal sequence binding
AZF00_11380	COG1845	cytochrome c oxidase, subunit III
AZF00_11385	COG1845	cytochrome c oxidase, subunit III
AZF00_11390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZF00_11395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AZF00_11400	COG1522	sequence-specific DNA binding
AZF00_11425	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AZF00_11440	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_11450	COG2307	Protein conserved in bacteria
AZF00_11450	COG2308	Evidence 4 Homologs of previously reported genes of
AZF00_11460	COG2308	Evidence 4 Homologs of previously reported genes of
AZF00_11485	COG0425	Belongs to the sulfur carrier protein TusA family
AZF00_11490	COG4783	chaperone-mediated protein folding
AZF00_11500	COG4628	conserved protein (DUF2132)
AZF00_11505	COG0243	molybdopterin cofactor binding
AZF00_11510	COG2046	Belongs to the sulfate adenylyltransferase family
AZF00_11515	COG0529	Catalyzes the synthesis of activated sulfate
AZF00_11520	COG0583	DNA-binding transcription factor activity
AZF00_11535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZF00_11545	COG1960	acyl-CoA dehydrogenase activity
AZF00_11575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AZF00_11585	COG1677	Flagellar hook-basal body complex protein FliE
AZF00_11590	COG2204	response regulator
AZF00_11600	COG3604	Transcriptional regulator
AZF00_11615	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AZF00_11635	COG1684	flagellar biosynthetic protein fliR
AZF00_11640	COG1987	bacterial-type flagellum assembly
AZF00_11650	COG3190	flagellar
AZF00_11670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZF00_11680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZF00_11695	COG0439	Biotin carboxylase
AZF00_11705	COG0393	Putative heavy-metal-binding
AZF00_11730	COG2264	protein methyltransferase activity
AZF00_11740	COG0564	pseudouridine synthase activity
AZF00_11755	COG4372	Transposase
AZF00_11760	COG3436	PFAM IS66 Orf2 family protein
AZF00_11795	COG1429	ligase activity, forming nitrogen-metal bonds
AZF00_11835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AZF00_11840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZF00_11845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AZF00_11850	COG2814	Major facilitator Superfamily
AZF00_11875	COG0674	pyruvate-flavodoxin oxidoreductase activity
AZF00_11875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AZF00_11880	COG0493	'glutamate synthase
AZF00_11880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZF00_11885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AZF00_11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZF00_11895	COG3153	acetyltransferase
AZF00_11900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZF00_11905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AZF00_11910	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AZF00_11915	COG1982	Orn Lys Arg decarboxylase major
AZF00_11950	COG0501	Belongs to the peptidase M48B family
AZF00_11955	COG0235	Class ii aldolase
AZF00_11965	COG1643	Atp-dependent helicase
AZF00_11975	COG3040	lipid binding
AZF00_11995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AZF00_12000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AZF00_12005	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AZF00_12035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AZF00_12050	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AZF00_12050	COG0778	Nitroreductase
AZF00_12060	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12070	COG0469	pyruvate kinase activity
AZF00_12080	COG0346	lactoylglutathione lyase activity
AZF00_12095	COG2081	HI0933 family
AZF00_12100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AZF00_12110	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12120	COG4145	pantothenate transmembrane transporter activity
AZF00_12125	COG4771	TonB-dependent receptor
AZF00_12140	COG1960	acyl-CoA dehydrogenase activity
AZF00_12145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AZF00_12170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AZF00_12175	COG4771	TonB-dependent receptor
AZF00_12195	COG0583	DNA-binding transcription factor activity
AZF00_12200	COG1090	epimerase
AZF00_12220	COG1960	acyl-CoA dehydrogenase activity
AZF00_12230	COG1960	acyl-CoA dehydrogenase activity
AZF00_12245	COG1454	alcohol dehydrogenase
AZF00_12255	COG1946	Acyl-CoA thioesterase
AZF00_12265	COG1024	Enoyl-CoA hydratase
AZF00_12270	COG0778	Nitroreductase
AZF00_12275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZF00_12280	COG1024	Enoyl-CoA hydratase
AZF00_12310	COG2832	Protein of unknown function (DUF454)
AZF00_12320	COG1160	GTP binding
AZF00_12330	COG2976	Protein conserved in bacteria
AZF00_12335	COG0124	histidyl-tRNA synthetase
AZF00_12340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AZF00_12355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AZF00_12360	COG0105	UTP biosynthetic process
AZF00_12375	COG0443	Heat shock 70 kDa protein
AZF00_12380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AZF00_12385	COG0316	Belongs to the HesB IscA family
AZF00_12390	COG0822	iron-sulfur transferase activity
AZF00_12410	COG0037	tRNA processing
AZF00_12415	COG0825	malonyl-CoA metabolic process
AZF00_12425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AZF00_12430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZF00_12435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZF00_12440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AZF00_12465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AZF00_12475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AZF00_12480	COG0233	cytoplasmic translational termination
AZF00_12485	COG0528	UMP kinase activity
AZF00_12490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AZF00_12495	COG0052	Belongs to the universal ribosomal protein uS2 family
AZF00_12500	COG0024	Methionine aminopeptidase
AZF00_12510	COG0436	Aminotransferase
AZF00_12515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AZF00_12520	COG1393	Belongs to the ArsC family
AZF00_12525	COG2171	N-acyltransferase activity
AZF00_12550	COG2072	flavoprotein involved in K transport
AZF00_12590	COG0625	glutathione transferase activity
AZF00_12600	COG3119	arylsulfatase activity
AZF00_12615	COG0625	glutathione transferase activity
AZF00_12625	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12635	COG1234	tRNA 3'-trailer cleavage
AZF00_12655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AZF00_12665	COG4681	YaeQ
AZF00_12715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZF00_12735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AZF00_12750	COG0596	Alpha beta hydrolase
AZF00_12765	COG2124	cytochrome p450
AZF00_12785	COG1454	alcohol dehydrogenase
AZF00_12835	COG1902	pentaerythritol trinitrate reductase activity
AZF00_12865	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZF00_12885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AZF00_12890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZF00_12895	COG4771	TonB-dependent receptor
AZF00_12915	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZF00_12930	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12935	COG1309	transcriptional regulator
AZF00_12940	COG0446	pyridine nucleotide-disulphide oxidoreductase
AZF00_12940	COG1902	pentaerythritol trinitrate reductase activity
AZF00_12945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AZF00_12950	COG4771	TonB-dependent receptor
AZF00_12955	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_12980	COG2902	Dehydrogenase
AZF00_12985	COG0668	transmembrane transport
AZF00_12995	COG1199	ATP-dependent helicase activity
AZF00_12995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZF00_12995	COG1199	ATP-dependent helicase activity
AZF00_12995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZF00_13010	COG3263	regulation of cellular component size
AZF00_13020	COG0469	pyruvate kinase activity
AZF00_13030	COG1737	Transcriptional regulator
AZF00_13035	COG0800	Aldolase
AZF00_13040	COG0363	glucosamine-6-phosphate deaminase activity
AZF00_13045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AZF00_13050	COG0129	dihydroxy-acid dehydratase activity
AZF00_13060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AZF00_13060	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AZF00_13065	COG0246	Mannitol dehydrogenase
AZF00_13080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AZF00_13095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AZF00_13100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZF00_13140	COG0463	Glycosyl transferase, family 2
AZF00_13170	COG5001	Diguanylate cyclase
AZF00_13170	COG3300	MHYT domain
AZF00_13175	COG0783	Belongs to the Dps family
AZF00_13190	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_13235	COG4221	oxidoreductase activity
AZF00_13260	COG1272	protein, Hemolysin III
AZF00_13280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AZF00_13290	COG2995	paraquat-inducible protein a
AZF00_13295	COG3008	intermembrane lipid transfer
AZF00_13300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZF00_13315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AZF00_13320	COG0616	signal peptide processing
AZF00_13340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZF00_13355	COG0861	Integral membrane protein TerC family
AZF00_13365	COG2205	protein histidine kinase activity
AZF00_13365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZF00_13385	COG2204	response regulator
AZF00_13395	COG0784	Response regulator, receiver
AZF00_13395	COG5002	protein histidine kinase activity
AZF00_13395	COG2205	protein histidine kinase activity
AZF00_13400	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AZF00_13425	COG1216	Glycosyl transferase, family 2
AZF00_13435	COG1216	Glycosyl transferase, family 2
AZF00_13435	COG0463	Glycosyl transferase, family 2
AZF00_13445	COG1215	transferase activity, transferring glycosyl groups
AZF00_13460	COG3300	MHYT domain
AZF00_13460	COG5001	Diguanylate cyclase
AZF00_13465	COG2198	Histidine kinase
AZF00_13465	COG5002	protein histidine kinase activity
AZF00_13465	COG0784	Response regulator, receiver
AZF00_13540	COG4964	Belongs to the GSP D family
AZF00_13565	COG0668	transmembrane transport
AZF00_13580	COG0235	Class ii aldolase
AZF00_13595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AZF00_13615	COG0439	Biotin carboxylase
AZF00_13630	COG3842	ATPase activity
AZF00_13655	COG1785	Belongs to the alkaline phosphatase family
AZF00_13665	COG0546	phosphoglycolate phosphatase activity
AZF00_13670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AZF00_13675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AZF00_13680	COG3178	'Phosphotransferase
AZF00_13685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AZF00_13690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZF00_13695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AZF00_13700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AZF00_13705	COG2967	ApaG domain
AZF00_13710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AZF00_13715	COG0617	tRNA 3'-terminal CCA addition
AZF00_13730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AZF00_13730	COG0302	gtp cyclohydrolase
AZF00_13735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AZF00_13740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AZF00_13745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AZF00_13755	COG0358	DNA primase activity
AZF00_13770	COG2205	protein histidine kinase activity
AZF00_13770	COG0784	Response regulator, receiver
AZF00_13775	COG0745	RESPONSE REGULATOR receiver
AZF00_13790	COG0477	Major facilitator Superfamily
AZF00_13795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AZF00_13800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZF00_13805	COG1845	cytochrome c oxidase, subunit III
AZF00_13810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AZF00_13815	COG3346	SURF1 family
AZF00_13825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AZF00_13875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AZF00_13880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AZF00_13885	COG1183	phosphatidylcholine synthase activity
AZF00_13890	COG0583	DNA-binding transcription factor activity
AZF00_13895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AZF00_13930	COG0633	Ferredoxin
AZF00_13935	COG4771	TonB-dependent receptor
AZF00_13945	COG1454	alcohol dehydrogenase
AZF00_13955	COG2207	Transcriptional regulator
AZF00_13975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AZF00_13995	COG0784	Response regulator, receiver
AZF00_13995	COG2205	protein histidine kinase activity
AZF00_14000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AZF00_14020	COG0604	alcohol dehydrogenase
AZF00_14055	COG0183	Belongs to the thiolase family
AZF00_14060	COG1960	acyl-CoA dehydrogenase activity
AZF00_14105	COG0028	Belongs to the TPP enzyme family
AZF00_14155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AZF00_14160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AZF00_14160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZF00_14230	COG4968	Prepilin-type N-terminal cleavage methylation domain
AZF00_14240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AZF00_14245	COG1047	Peptidyl-prolyl cis-trans
AZF00_14250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AZF00_14255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AZF00_14260	COG0196	riboflavin kinase activity
AZF00_14265	COG0728	peptidoglycan biosynthetic process
AZF00_14270	COG0494	nUDIX hydrolase
AZF00_14275	COG0540	Belongs to the ATCase OTCase family
AZF00_14280	COG1132	(ABC) transporter
AZF00_14285	COG2827	Endonuclease containing a URI domain
AZF00_14290	COG2925	Exonuclease
AZF00_14320	COG0676	glucose-6-phosphate 1-epimerase activity
AZF00_14335	COG0110	maltose O-acetyltransferase activity
AZF00_14340	COG0459	protein refolding
AZF00_14345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AZF00_14360	COG0288	reversible hydration of carbon dioxide
AZF00_14370	COG2814	Major facilitator Superfamily
AZF00_14375	COG1666	GTP binding
AZF00_14385	COG4206	TonB-dependent receptor
AZF00_14400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AZF00_14405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AZF00_14410	COG0778	Nitroreductase
AZF00_14415	COG1492	cobalamin metabolic process
AZF00_14435	COG0406	alpha-ribazole phosphatase activity
AZF00_14450	COG2096	Adenosyltransferase
AZF00_14455	COG1940	carbohydrate kinase activity
AZF00_14460	COG3725	Membrane protein required for beta-lactamase induction
AZF00_14465	COG3023	N-Acetylmuramoyl-L-alanine amidase
AZF00_14505	COG0237	dephospho-CoA kinase activity
AZF00_14510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AZF00_14515	COG0494	nUDIX hydrolase
AZF00_14525	COG0653	protein targeting
AZF00_14530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AZF00_14545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AZF00_14550	COG1181	Belongs to the D-alanine--D-alanine ligase family
AZF00_14555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZF00_14560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZF00_14565	COG0772	Belongs to the SEDS family
AZF00_14575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZF00_14580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AZF00_14595	COG3116	cell division
AZF00_14600	COG0275	rRNA processing
AZF00_14605	COG2001	Belongs to the MraZ family
AZF00_14620	COG3107	peptidoglycan biosynthetic process
AZF00_14625	COG0792	nuclease activity
AZF00_14630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AZF00_14635	COG2823	Periplasmic or secreted lipoprotein
AZF00_14640	COG2969	positive regulation of protein catabolic process
AZF00_14645	COG0625	glutathione transferase activity
AZF00_14650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AZF00_14655	COG0723	plastoquinol--plastocyanin reductase activity
AZF00_14660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AZF00_14665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AZF00_14670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AZF00_14685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZF00_14690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZF00_14695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AZF00_14700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AZF00_14705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AZF00_14725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AZF00_14740	COG1137	ATPase activity
AZF00_14745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AZF00_14760	COG1660	Displays ATPase and GTPase activities
AZF00_14770	COG2239	Acts as a magnesium transporter
AZF00_14775	COG3028	Belongs to the UPF0307 family
AZF00_14780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZF00_14785	COG3164	Protein of unknown function
AZF00_14790	COG1530	ribonuclease E activity
AZF00_14795	COG0424	maF-like protein
AZF00_14800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AZF00_14805	COG1792	Involved in formation and maintenance of cell shape
AZF00_14810	COG1077	Cell shape determining protein MreB Mrl
AZF00_14815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZF00_14820	COG0154	amidase activity
AZF00_14825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZF00_14835	COG2840	Smr protein MutS2
AZF00_14865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZF00_14870	COG2890	protein-(glutamine-N5) methyltransferase activity
AZF00_14875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AZF00_14880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AZF00_14895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AZF00_14905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AZF00_14910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AZF00_14915	COG0193	aminoacyl-tRNA hydrolase activity
AZF00_14940	COG4106	trans-aconitate 2-methyltransferase activity
AZF00_14945	COG0500	methyltransferase
AZF00_14955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZF00_14965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZF00_14970	COG1702	phosphate starvation-inducible protein PhoH
AZF00_14975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AZF00_14980	COG4535	Mg2 and Co2 transporter CorC
AZF00_14990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AZF00_14995	COG0495	leucyl-tRNA aminoacylation
AZF00_15000	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AZF00_15015	COG0321	lipoyl(octanoyl) transferase activity
AZF00_15020	COG2921	Belongs to the UPF0250 family
AZF00_15025	COG1686	Belongs to the peptidase S11 family
AZF00_15030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AZF00_15035	COG2951	lytic endotransglycosylase activity
AZF00_15040	COG0772	Belongs to the SEDS family
AZF00_15045	COG0768	penicillin binding
AZF00_15050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AZF00_15060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AZF00_15065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AZF00_15085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZF00_15110	COG0811	peptide transport
AZF00_15140	COG2223	nitrite transmembrane transporter activity
AZF00_15145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZF00_15150	COG2146	nitrite reductase [NAD(P)H] activity
AZF00_15165	COG1045	serine acetyltransferase
AZF00_15170	COG1876	peptidase activity
AZF00_15175	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZF00_15185	COG1489	DNA binding
AZF00_15200	COG1187	pseudouridine synthase activity
AZF00_15215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AZF00_15220	COG0513	Belongs to the DEAD box helicase family
AZF00_15245	COG0513	Belongs to the DEAD box helicase family
AZF00_15250	COG1278	Cold shock
AZF00_15255	COG0436	Aminotransferase
AZF00_15265	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AZF00_15275	COG2116	formate transmembrane transporter activity
AZF00_15285	COG1309	transcriptional regulator
AZF00_15295	COG0583	DNA-binding transcription factor activity
AZF00_15325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AZF00_15330	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AZF00_15335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AZF00_15335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AZF00_15345	COG0709	Synthesizes selenophosphate from selenide and ATP
AZF00_15365	COG0784	Response regulator, receiver
AZF00_15370	COG4251	negative regulation of phosphorylation
AZF00_15375	COG4251	negative regulation of phosphorylation
AZF00_15385	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AZF00_15395	COG0137	argininosuccinate synthase activity
AZF00_15405	COG1176	ABC-type spermidine putrescine transport system, permease component I
AZF00_15410	COG1177	transmembrane transport
AZF00_15420	COG1555	photosystem II stabilization
AZF00_15425	COG0418	dihydroorotase activity
AZF00_15430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZF00_15440	COG0450	alkyl hydroperoxide reductase
AZF00_15470	COG1730	sister chromatid segregation
AZF00_15475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AZF00_15485	COG4771	TonB-dependent receptor
AZF00_15495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZF00_15505	COG3842	ATPase activity
AZF00_15510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AZF00_15510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZF00_15515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZF00_15545	COG0154	amidase activity
AZF00_15575	COG0385	Bile acid
AZF00_15585	COG4771	TonB-dependent receptor
AZF00_15630	COG2135	peptidase activity
AZF00_15635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AZF00_15640	COG0583	DNA-binding transcription factor activity
AZF00_15645	COG3383	formate dehydrogenase (NAD+) activity
AZF00_15665	COG1959	2 iron, 2 sulfur cluster binding
AZF00_15680	COG0754	glutathionylspermidine amidase activity
AZF00_15685	COG0625	glutathione transferase activity
AZF00_15695	COG0697	spore germination
AZF00_15775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AZF00_15810	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_15825	COG0583	DNA-binding transcription factor activity
AZF00_15860	COG4771	TonB-dependent receptor
AZF00_15880	COG2824	Alkylphosphonate utilization operon protein PhnA
AZF00_15890	COG0739	heme binding
AZF00_15895	COG0123	including yeast histone deacetylase and acetoin utilization protein
AZF00_15925	COG5265	(ABC) transporter
AZF00_15935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZF00_15940	COG2226	methyltransferase
AZF00_15950	COG0714	Associated with various cellular activities
AZF00_15970	COG2304	oxidoreductase activity
AZF00_15980	COG0697	spore germination
AZF00_16005	COG4251	negative regulation of phosphorylation
AZF00_16045	COG4191	Histidine kinase
AZF00_16055	COG4566	intracellular signal transduction
AZF00_16065	COG1199	ATP-dependent helicase activity
AZF00_16080	COG3437	response regulator, receiver
AZF00_16080	COG3850	Histidine kinase
AZF00_16080	COG2205	protein histidine kinase activity
AZF00_16080	COG4999	Histidine kinase
AZF00_16155	COG0431	NADPH-dependent FMN reductase
AZF00_16165	COG0318	PFAM AMP-dependent synthetase and ligase
AZF00_16185	COG0811	peptide transport
AZF00_16215	COG1304	FMN binding
AZF00_16220	COG3128	pkhd-type hydroxylase
AZF00_16225	COG0850	regulation of cytokinetic process
AZF00_16235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AZF00_16255	COG1671	Belongs to the UPF0178 family
AZF00_16280	COG0667	Aldo Keto reductase
AZF00_16300	COG2226	methyltransferase
AZF00_16315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AZF00_16320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZF00_16330	COG0604	alcohol dehydrogenase
AZF00_16335	COG0583	DNA-binding transcription factor activity
AZF00_16340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AZF00_16340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AZF00_16355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AZF00_16360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AZF00_16370	COG0693	protein deglycase activity
AZF00_16385	COG5285	phytanoyl-CoA dioxygenase
AZF00_16390	COG1902	pentaerythritol trinitrate reductase activity
AZF00_16405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AZF00_16410	COG2363	Small membrane protein
AZF00_16425	COG2177	Part of the ABC transporter FtsEX involved in
AZF00_16430	COG2884	Cell division ATP-binding protein ftsE
AZF00_16440	COG0742	ribosomal rna small subunit methyltransferase
AZF00_16460	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZF00_16465	COG1309	transcriptional regulator
AZF00_16510	COG0848	biopolymer transport protein
AZF00_16515	COG0811	peptide transport
AZF00_16520	COG0811	peptide transport
AZF00_16535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AZF00_16540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AZF00_16545	COG0730	response to heat
AZF00_16555	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
AZF00_16570	COG0509	glycine decarboxylation via glycine cleavage system
AZF00_16575	COG1178	ABC-type Fe3 transport system permease component
AZF00_16585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AZF00_16590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AZF00_16595	COG0006	proline dipeptidase activity
AZF00_16600	COG3079	Belongs to the UPF0149 family
AZF00_16625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AZF00_16630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AZF00_16635	COG0179	Fumarylacetoacetate (FAA) hydrolase
AZF00_16640	COG0277	FAD linked oxidase domain protein
AZF00_16645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZF00_16660	COG4221	oxidoreductase activity
AZF00_16675	COG1970	mechanosensitive ion channel activity
AZF00_16695	COG0142	geranyltranstransferase activity
AZF00_16700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AZF00_16725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AZF00_16735	COG0352	thiamine-phosphate diphosphorylase activity
AZF00_16740	COG0745	RESPONSE REGULATOR receiver
AZF00_16810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AZF00_16835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AZF00_16840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AZF00_16845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AZF00_16855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AZF00_16870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZF00_16870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZF00_16875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AZF00_16880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZF00_16890	COG0488	(ABC) transporter
AZF00_16910	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_16925	COG0281	malic enzyme
AZF00_16930	COG0254	rRNA binding
AZF00_16940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AZF00_16955	COG0018	arginyl-trna synthetase
AZF00_16965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AZF00_16970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AZF00_16985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AZF00_16990	COG0557	exoribonuclease II activity
AZF00_17010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AZF00_17020	COG2070	2-Nitropropane dioxygenase
AZF00_17025	COG0307	riboflavin synthase, alpha
AZF00_17045	COG2885	chlorophyll binding
AZF00_17070	COG0583	DNA-binding transcription factor activity
AZF00_17075	COG2814	Major facilitator Superfamily
AZF00_17090	COG2885	chlorophyll binding
AZF00_17110	COG2968	Membrane
AZF00_17115	COG1012	belongs to the aldehyde dehydrogenase family
AZF00_17120	COG0189	ligase activity
AZF00_17120	COG4067	protein conserved in archaea
AZF00_17125	COG0189	ligase activity
AZF00_17170	COG2161	toxin-antitoxin pair type II binding
AZF00_17175	COG3668	Plasmid stabilization system
AZF00_17195	COG2304	oxidoreductase activity
AZF00_17200	COG3634	alkyl hydroperoxide reductase activity
AZF00_17205	COG0450	alkyl hydroperoxide reductase
AZF00_17215	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_17225	COG0488	(ABC) transporter
AZF00_17230	COG0446	pyridine nucleotide-disulphide oxidoreductase
AZF00_17230	COG1902	pentaerythritol trinitrate reductase activity
AZF00_17235	COG4771	TonB-dependent receptor
AZF00_17265	COG4771	TonB-dependent receptor
AZF00_17300	COG0488	(ABC) transporter
AZF00_17305	COG0625	glutathione transferase activity
AZF00_17320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZF00_17320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AZF00_17325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AZF00_17340	COG0840	transmembrane signaling receptor activity
AZF00_17360	COG0189	ligase activity
AZF00_17370	COG1678	Uncharacterized ACR, COG1678
AZF00_17375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AZF00_17405	COG1872	DUF167
AZF00_17410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AZF00_17415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AZF00_17415	COG2813	Specifically methylates the guanine in position
AZF00_17425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AZF00_17445	COG0583	DNA-binding transcription factor activity
AZF00_17455	COG1022	Amp-dependent synthetase and ligase
AZF00_17465	COG2814	Major facilitator Superfamily
AZF00_17470	COG0500	methyltransferase
AZF00_17495	COG2959	enzyme of heme biosynthesis
AZF00_17515	COG3275	phosphorelay sensor kinase activity
AZF00_17525	COG0165	Argininosuccinate lyase
AZF00_17600	COG0438	transferase activity, transferring glycosyl groups
AZF00_17625	COG1392	Phosphate transport regulator
AZF00_17630	COG0306	phosphate transporter
AZF00_17655	COG0406	alpha-ribazole phosphatase activity
AZF00_17685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AZF00_17695	COG2003	Belongs to the UPF0758 family
AZF00_17700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AZF00_17705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AZF00_17710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZF00_17715	COG1309	transcriptional regulator
AZF00_17740	COG1561	YicC-like family, N-terminal region
AZF00_17765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AZF00_17775	COG3383	formate dehydrogenase (NAD+) activity
AZF00_17780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZF00_17790	COG0730	response to heat
AZF00_17800	COG2814	Major facilitator Superfamily
AZF00_17825	COG2267	carboxylic ester hydrolase activity
AZF00_17850	COG1028	Short-chain dehydrogenase reductase Sdr
AZF00_17925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AZF00_17965	COG0194	GDP metabolic process
AZF00_17970	COG1758	RNA polymerase activity
AZF00_17975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZF00_17995	COG0583	DNA-binding transcription factor activity
AZF00_18000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AZF00_18010	COG3152	Membrane
AZF00_18020	COG1403	HNH endonuclease
AZF00_18045	COG0642	Histidine kinase
AZF00_18050	COG0745	RESPONSE REGULATOR receiver
AZF00_18090	COG1737	Transcriptional regulator
AZF00_18100	COG0210	DNA helicase
AZF00_18105	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AZF00_18110	COG1309	transcriptional regulator
AZF00_18115	COG0318	PFAM AMP-dependent synthetase and ligase
AZF00_18145	COG1607	acyl-coa hydrolase
AZF00_18170	COG3022	response to hydroperoxide
AZF00_18185	COG2885	chlorophyll binding
AZF00_18210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AZF00_18215	COG3161	chorismate lyase activity
AZF00_18220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZF00_18235	COG0631	protein serine/threonine phosphatase activity
AZF00_18245	COG2226	methyltransferase
AZF00_18250	COG1301	dicarboxylic acid transport
AZF00_18260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZF00_18265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AZF00_18270	COG2226	methyltransferase
AZF00_18290	COG3604	Transcriptional regulator
AZF00_18295	COG1271	oxidase subunit
AZF00_18300	COG1294	oxidase, subunit
AZF00_18315	COG4771	TonB-dependent receptor
AZF00_18325	COG2272	Belongs to the type-B carboxylesterase lipase family
AZF00_18335	COG0471	metal ion transport
AZF00_18370	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AZF00_18395	COG1253	flavin adenine dinucleotide binding
AZF00_18420	COG4771	TonB-dependent receptor
AZF00_18435	COG0277	FAD linked oxidase domain protein
AZF00_18500	COG4771	TonB-dependent receptor
AZF00_18580	COG0459	protein refolding
AZF00_18585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AZF00_18610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AZF00_18615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AZF00_18620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AZF00_18625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AZF00_18630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AZF00_18635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZF00_18640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZF00_18650	COG0356	it plays a direct role in the translocation of protons across the membrane
AZF00_18660	COG1475	DNA binding
AZF00_18665	COG1192	Involved in chromosome partitioning
AZF00_18670	COG0357	Ribosomal RNA small subunit methyltransferase G
AZF00_18675	COG0445	tRNA wobble uridine modification
AZF00_18680	COG4999	Histidine kinase
AZF00_18680	COG3437	response regulator, receiver
AZF00_18680	COG2205	protein histidine kinase activity
AZF00_18680	COG3850	Histidine kinase
AZF00_18695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AZF00_18700	COG0706	membrane insertase activity
AZF00_18710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AZF00_18720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AZF00_18735	COG0751	glycine-tRNA ligase activity
AZF00_18740	COG0752	glycyl-tRNA synthetase alpha subunit
AZF00_18745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AZF00_18750	COG3141	response to X-ray
AZF00_18765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AZF00_18770	COG0569	domain protein
AZF00_18785	COG0242	peptide deformylase activity
AZF00_18795	COG0758	DNA mediated transformation