locus-tag	class	description
AN401_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN401_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN401_00020	COG0187	DNA topoisomerase II activity
AN401_00025	COG0129	dihydroxy-acid dehydratase activity
AN401_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
AN401_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
AN401_00040	COG3977	Valine--pyruvate aminotransferase
AN401_00050	COG0751	glycine-tRNA ligase activity
AN401_00055	COG0752	glycyl-tRNA synthetase alpha subunit
AN401_00060	COG2818	Glycosylase
AN401_00065	COG2885	chlorophyll binding
AN401_00075	COG0425	Belongs to the sulfur carrier protein TusA family
AN401_00080	COG0183	Belongs to the thiolase family
AN401_00085	COG1024	Enoyl-CoA hydratase
AN401_00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN401_00090	COG1739	Uncharacterized protein family UPF0029
AN401_00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN401_00100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AN401_00130	COG4989	oxidoreductase activity
AN401_00135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN401_00135	COG0045	succinate-CoA ligase (ADP-forming) activity
AN401_00135	COG1042	CoA-binding domain protein
AN401_00140	COG2200	EAL domain
AN401_00140	COG2202	Pas domain
AN401_00140	COG2199	diguanylate cyclase activity
AN401_00155	COG3135	benzoate transporter
AN401_00160	COG2814	Major facilitator Superfamily
AN401_00185	COG3485	protocatechuate 3,4-dioxygenase
AN401_00195	COG4948	Mandelate Racemase Muconate Lactonizing
AN401_00205	COG1414	Transcriptional regulator
AN401_00210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AN401_00215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AN401_00220	COG0183	Belongs to the thiolase family
AN401_00225	COG2267	carboxylic ester hydrolase activity
AN401_00230	COG0840	transmembrane signaling receptor activity
AN401_00240	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AN401_00250	COG1575	Belongs to the MenA family. Type 1 subfamily
AN401_00255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AN401_00265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN401_00275	COG2022	thiamine diphosphate biosynthetic process
AN401_00280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN401_00290	COG1984	allophanate hydrolase subunit 2
AN401_00295	COG1984	allophanate hydrolase subunit 2
AN401_00300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AN401_00305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AN401_00325	COG2188	Transcriptional regulator
AN401_00330	COG1486	melibiose metabolic process
AN401_00340	COG1253	flavin adenine dinucleotide binding
AN401_00355	COG0601	transmembrane transport
AN401_00360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_00365	COG4172	Belongs to the ABC transporter superfamily
AN401_00380	COG1288	antiporter activity
AN401_00385	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AN401_00395	COG2084	Dehydrogenase
AN401_00400	COG3622	Belongs to the hyi family
AN401_00405	COG3960	tartronate-semialdehyde synthase activity
AN401_00415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN401_00425	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AN401_00435	COG0745	RESPONSE REGULATOR receiver
AN401_00465	COG1047	Peptidyl-prolyl cis-trans
AN401_00470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_00475	COG0339	signal peptide processing
AN401_00485	COG0742	ribosomal rna small subunit methyltransferase
AN401_00500	COG0523	cobalamin synthesis protein
AN401_00505	COG0604	alcohol dehydrogenase
AN401_00520	COG0589	response to stress
AN401_00530	COG2081	HI0933 family
AN401_00545	COG1253	flavin adenine dinucleotide binding
AN401_00550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN401_00555	COG0800	Aldolase
AN401_00575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_00580	COG1609	Transcriptional regulator
AN401_00585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_00600	COG0656	L-ascorbic acid biosynthetic process
AN401_00610	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AN401_00615	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AN401_00630	COG0561	phosphatase activity
AN401_00635	COG2267	carboxylic ester hydrolase activity
AN401_00640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN401_00645	COG1758	RNA polymerase activity
AN401_00650	COG0194	GDP metabolic process
AN401_00665	COG1561	YicC-like family, N-terminal region
AN401_00680	COG0668	transmembrane transport
AN401_00685	COG1309	transcriptional regulator
AN401_00690	COG0756	dUTP diphosphatase activity
AN401_00695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AN401_00700	COG2003	Belongs to the UPF0758 family
AN401_00710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN401_00715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN401_00720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN401_00725	COG0859	PFAM glycosyl transferase family 9
AN401_00730	COG0463	Glycosyl transferase, family 2
AN401_00735	COG0859	PFAM glycosyl transferase family 9
AN401_00740	COG3642	lipopolysaccharide core region biosynthetic process
AN401_00745	COG1519	Transferase
AN401_00750	COG0859	PFAM glycosyl transferase family 9
AN401_00765	COG0726	polysaccharide deacetylase
AN401_00770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN401_00780	COG0156	8-amino-7-oxononanoate synthase activity
AN401_00785	COG1063	alcohol dehydrogenase
AN401_00795	COG0683	leucine binding
AN401_00800	COG0559	Belongs to the binding-protein-dependent transport system permease family
AN401_00815	COG0410	ABC transporter
AN401_00820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_00835	COG3161	chorismate lyase activity
AN401_00840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AN401_00845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN401_00850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AN401_00850	COG1565	acr, cog1565
AN401_00855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AN401_00885	COG1612	heme a metabolic process
AN401_00890	COG0109	protoheme IX farnesyltransferase activity
AN401_00900	COG0534	Mate efflux family protein
AN401_00905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN401_00925	COG3074	FtsZ-dependent cytokinesis
AN401_00930	COG3610	response to peptide
AN401_00935	COG2966	Psort location CytoplasmicMembrane, score
AN401_00940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_00945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AN401_00950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AN401_00955	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN401_00960	COG0018	arginyl-trna synthetase
AN401_00970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN401_00975	COG0254	rRNA binding
AN401_00985	COG0281	malic enzyme
AN401_00990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN401_00995	COG4206	TonB-dependent receptor
AN401_01005	COG0724	RNA recognition motif
AN401_01035	COG0671	phosphoesterase, PA-phosphatase related
AN401_01040	COG0583	DNA-binding transcription factor activity
AN401_01050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN401_01055	COG3047	cAMP biosynthetic process
AN401_01060	COG0579	oxidoreductase
AN401_01070	COG1802	Transcriptional regulator
AN401_01075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN401_01095	COG1279	arginine transmembrane transporter activity
AN401_01100	COG2873	o-acetylhomoserine
AN401_01105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN401_01110	COG2873	o-acetylhomoserine
AN401_01115	COG2205	protein histidine kinase activity
AN401_01120	COG0745	RESPONSE REGULATOR receiver
AN401_01130	COG1522	sequence-specific DNA binding
AN401_01135	COG2502	aspartate--ammonia ligase
AN401_01140	COG0517	IMP dehydrogenase activity
AN401_01140	COG1125	glycine betaine transport
AN401_01145	COG2205	protein histidine kinase activity
AN401_01155	COG2204	response regulator
AN401_01175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN401_01200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN401_01235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN401_01245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN401_01250	COG0250	Participates in transcription elongation, termination and antitermination
AN401_01255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AN401_01265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN401_01275	COG0085	RNA polymerase activity
AN401_01280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN401_01285	COG1024	Enoyl-CoA hydratase
AN401_01290	COG2847	Copper chaperone PCu(A)C
AN401_01295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AN401_01300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN401_01305	COG0175	sulfate reduction
AN401_01310	COG0517	IMP dehydrogenase activity
AN401_01315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN401_01315	COG1648	precorrin-2 dehydrogenase activity
AN401_01325	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AN401_01330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN401_01335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN401_01340	COG0163	prenyltransferase activity
AN401_01350	COG1131	(ABC) transporter
AN401_01355	COG0842	Transport permease protein
AN401_01360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AN401_01365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN401_01370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AN401_01380	COG0617	tRNA 3'-terminal CCA addition
AN401_01385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN401_01390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN401_01395	COG1489	DNA binding
AN401_01405	COG1643	Atp-dependent helicase
AN401_01410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN401_01420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AN401_01430	COG0316	Belongs to the HesB IscA family
AN401_01450	COG0739	heme binding
AN401_01455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN401_01465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_01475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AN401_01480	COG0493	'glutamate synthase
AN401_01485	COG0069	glutamate synthase activity
AN401_01485	COG0067	glutamate synthase
AN401_01485	COG0070	glutamate synthase
AN401_01490	COG0784	Response regulator, receiver
AN401_01490	COG2198	Histidine kinase
AN401_01490	COG5002	protein histidine kinase activity
AN401_01510	COG1464	Belongs to the NlpA lipoprotein family
AN401_01515	COG2011	ABC-type metal ion transport system permease component
AN401_01525	COG4174	ABC transporter (Permease)
AN401_01530	COG4239	(ABC) transporter, permease
AN401_01535	COG0747	negative chemotaxis
AN401_01540	COG0444	Belongs to the ABC transporter superfamily
AN401_01545	COG4608	Belongs to the ABC transporter superfamily
AN401_01550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AN401_01580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AN401_01590	COG1178	ABC-type Fe3 transport system permease component
AN401_01595	COG4143	(ABC) transporter
AN401_01610	COG0066	3-isopropylmalate dehydratase activity
AN401_01615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AN401_01620	COG0473	3-isopropylmalate dehydrogenase activity
AN401_01625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN401_01630	COG0028	Belongs to the TPP enzyme family
AN401_01640	COG2964	Protein conserved in bacteria
AN401_01645	COG0251	oxidation-reduction process
AN401_01660	COG2168	tRNA wobble position uridine thiolation
AN401_01665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN401_01670	COG0049	tRNA binding
AN401_01675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN401_01680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN401_01695	COG2906	2 iron, 2 sulfur cluster binding
AN401_01700	COG2193	ferroxidase activity
AN401_01705	COG1803	Methylglyoxal synthase
AN401_01720	COG1309	transcriptional regulator
AN401_01725	COG2814	Major facilitator Superfamily
AN401_01735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AN401_01745	COG0402	S-adenosylhomocysteine deaminase activity
AN401_01750	COG2186	Transcriptional regulator
AN401_01765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_01785	COG1234	tRNA 3'-trailer cleavage
AN401_01805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_01825	COG1012	belongs to the aldehyde dehydrogenase family
AN401_01845	COG2252	PERMEase
AN401_01865	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AN401_01870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AN401_01895	COG0840	transmembrane signaling receptor activity
AN401_01920	COG0583	DNA-binding transcription factor activity
AN401_01925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AN401_01935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN401_01950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN401_01955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AN401_01960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AN401_01965	COG1968	undecaprenyl-diphosphatase activity
AN401_01970	COG0617	tRNA 3'-terminal CCA addition
AN401_01995	COG4991	sh3 domain protein
AN401_02000	COG0306	phosphate transporter
AN401_02005	COG1392	Phosphate transport regulator
AN401_02010	COG3025	triphosphatase activity
AN401_02025	COG3789	protein conserved in bacteria
AN401_02035	COG1560	Kdo2-lipid A biosynthetic process
AN401_02040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AN401_02040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AN401_02050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN401_02050	COG2146	nitrite reductase [NAD(P)H] activity
AN401_02065	COG0243	molybdopterin cofactor binding
AN401_02070	COG1538	Outer membrane efflux protein
AN401_02075	COG0494	nUDIX hydrolase
AN401_02085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AN401_02090	COG3707	response regulator
AN401_02095	COG1116	anion transmembrane transporter activity
AN401_02100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN401_02105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN401_02110	COG3150	esterase
AN401_02115	COG0187	DNA topoisomerase II activity
AN401_02135	COG4948	Mandelate Racemase Muconate Lactonizing
AN401_02155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_02160	COG2186	Transcriptional regulator
AN401_02165	COG0494	nUDIX hydrolase
AN401_02170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AN401_02175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AN401_02180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN401_02200	COG0762	integral membrane protein
AN401_02205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN401_02210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AN401_02225	COG3022	response to hydroperoxide
AN401_02230	COG0513	Belongs to the DEAD box helicase family
AN401_02235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AN401_02250	COG0716	FMN binding
AN401_02270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN401_02290	COG2423	ornithine cyclodeaminase activity
AN401_02295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN401_02300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AN401_02305	COG1012	belongs to the aldehyde dehydrogenase family
AN401_02310	COG1522	sequence-specific DNA binding
AN401_02315	COG3608	succinylglutamate desuccinylase aspartoacylase
AN401_02320	COG0006	proline dipeptidase activity
AN401_02325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_02330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_02335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_02340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_02345	COG0006	proline dipeptidase activity
AN401_02355	COG1012	belongs to the aldehyde dehydrogenase family
AN401_02360	COG1473	amidohydrolase
AN401_02365	COG1301	dicarboxylic acid transport
AN401_02385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AN401_02395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AN401_02400	COG1595	DNA-templated transcription, initiation
AN401_02415	COG3086	response to oxidative stress
AN401_02420	COG0481	GTPase activity
AN401_02425	COG0681	Belongs to the peptidase S26 family
AN401_02430	COG0571	ribonuclease III activity
AN401_02455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN401_02460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN401_02465	COG3956	TIGRFAM MazG family protein
AN401_02470	COG1263	PTS System
AN401_02470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_02475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AN401_02480	COG1959	2 iron, 2 sulfur cluster binding
AN401_02485	COG4536	flavin adenine dinucleotide binding
AN401_02490	COG4137	Cytochrome C assembly protein
AN401_02495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AN401_02500	COG0228	four-way junction DNA binding
AN401_02505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN401_02510	COG0336	Belongs to the RNA methyltransferase TrmD family
AN401_02515	COG0335	large ribosomal subunit rRNA binding
AN401_02520	COG2814	Major facilitator Superfamily
AN401_02525	COG3066	DNA modification
AN401_02530	COG1051	belongs to the nudix hydrolase family
AN401_02540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN401_02545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN401_02550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN401_02555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN401_02595	COG4695	Portal protein
AN401_02605	COG5654	RES domain protein
AN401_02700	COG5433	transposase activity
AN401_02710	COG2856	Zn peptidase
AN401_02715	COG4974	Belongs to the 'phage' integrase family
AN401_02720	COG0583	DNA-binding transcription factor activity
AN401_02725	COG0640	Transcriptional regulator
AN401_02730	COG0268	Binds directly to 16S ribosomal RNA
AN401_02735	COG0728	peptidoglycan biosynthetic process
AN401_02740	COG0196	riboflavin kinase activity
AN401_02745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN401_02750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN401_02755	COG1047	Peptidyl-prolyl cis-trans
AN401_02760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN401_02765	COG3706	GGDEF domain
AN401_02770	COG4968	Prepilin-type N-terminal cleavage methylation domain
AN401_02785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN401_02785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_02790	COG0347	Belongs to the P(II) protein family
AN401_02800	COG0557	exoribonuclease II activity
AN401_02810	COG2153	protein acetylation
AN401_02820	COG0360	Binds together with S18 to 16S ribosomal RNA
AN401_02825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN401_02845	COG0612	Peptidase, M16
AN401_02850	COG2918	glutathione biosynthetic process
AN401_02855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_02860	COG0564	pseudouridine synthase activity
AN401_02870	COG0542	response to heat
AN401_02905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_02925	COG1802	Transcriptional regulator
AN401_02935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AN401_02955	COG0154	amidase activity
AN401_02975	COG0514	ATP-dependent DNA helicase (RecQ)
AN401_02980	COG0625	glutathione transferase activity
AN401_02985	COG2259	Doxx family
AN401_02990	COG1741	Belongs to the pirin family
AN401_03010	COG2267	carboxylic ester hydrolase activity
AN401_03015	COG3971	2-oxopent-4-enoate hydratase activity
AN401_03025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN401_03055	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AN401_03060	COG0540	Belongs to the ATCase OTCase family
AN401_03075	COG0456	acetyltransferase
AN401_03080	COG0739	heme binding
AN401_03095	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN401_03100	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AN401_03105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN401_03115	COG0583	DNA-binding transcription factor activity
AN401_03120	COG0840	transmembrane signaling receptor activity
AN401_03120	COG3290	protein histidine kinase activity
AN401_03125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AN401_03130	COG1687	branched-chain amino acid
AN401_03135	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AN401_03140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AN401_03140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AN401_03145	COG3639	organic phosphonate transmembrane transporter activity
AN401_03150	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_03160	COG0534	Mate efflux family protein
AN401_03170	COG1175	transmembrane transport
AN401_03180	COG1621	beta-fructofuranosidase activity
AN401_03215	COG0084	hydrolase, TatD family'
AN401_03220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AN401_03250	COG0560	Phosphoserine phosphatase
AN401_03260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AN401_03270	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AN401_03275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AN401_03280	COG0739	heme binding
AN401_03285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AN401_03290	COG1121	(ABC) transporter
AN401_03295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN401_03300	COG1573	uracil-dna glycosylase
AN401_03305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_03310	COG3068	Protein conserved in bacteria
AN401_03315	COG1846	Transcriptional regulator
AN401_03325	COG4681	YaeQ
AN401_03335	COG1228	amidohydrolase
AN401_03340	COG0010	Belongs to the arginase family
AN401_03350	COG2986	histidine ammonia-lyase
AN401_03360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN401_03370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_03375	COG1765	OsmC-like protein
AN401_03385	COG3954	Phosphoribulokinase
AN401_03390	COG3089	Belongs to the UPF0270 family
AN401_03395	COG0429	hydrolase of the alpha beta-hydrolase fold
AN401_03410	COG0583	DNA-binding transcription factor activity
AN401_03415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AN401_03425	COG0488	(ABC) transporter
AN401_03440	COG1047	Peptidyl-prolyl cis-trans
AN401_03455	COG0545	Peptidyl-prolyl cis-trans isomerase
AN401_03475	COG0534	Mate efflux family protein
AN401_03480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN401_03485	COG0459	protein refolding
AN401_03505	COG1509	lysine 2,3-aminomutase activity
AN401_03510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN401_03515	COG0516	GMP reductase activity
AN401_03530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AN401_03540	COG0583	DNA-binding transcription factor activity
AN401_03545	COG0471	metal ion transport
AN401_03550	COG3264	Mechanosensitive ion channel
AN401_03550	COG1511	domain protein
AN401_03555	COG0688	phosphatidylethanolamine metabolic process
AN401_03560	COG1162	GTPase activity
AN401_03565	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN401_03595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AN401_03595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AN401_03600	COG0802	atpase or kinase
AN401_03610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AN401_03620	COG1923	regulation of RNA biosynthetic process
AN401_03625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN401_03630	COG0330	HflC and HflK could
AN401_03635	COG0330	HflC and HflK could
AN401_03640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN401_03645	COG0142	geranyltranstransferase activity
AN401_03650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN401_03660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN401_03670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN401_03675	COG2967	ApaG domain
AN401_03680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN401_03685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AN401_03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN401_03695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AN401_03700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AN401_03705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN401_03720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN401_03755	COG1982	Orn Lys Arg decarboxylase major
AN401_03765	COG3048	D-serine ammonia-lyase activity
AN401_03770	COG1115	amino acid carrier protein
AN401_03775	COG1444	tRNA N-acetyltransferase activity
AN401_03785	COG2190	(PTS) system
AN401_03790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AN401_03795	COG2989	Protein conserved in bacteria
AN401_03800	COG3108	Peptidase M15
AN401_03810	COG3115	cell septum assembly
AN401_03815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN401_03825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN401_03850	COG2818	Glycosylase
AN401_03860	COG4181	ATPase activity
AN401_03865	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AN401_03875	COG1090	epimerase
AN401_03885	COG0857	belongs to the CobB CobQ family
AN401_03885	COG0280	phosphate acetyltransferase
AN401_03890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN401_03900	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AN401_03905	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AN401_03910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN401_03915	COG1053	succinate dehydrogenase
AN401_03925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_03930	COG1027	Aspartate ammonia-lyase
AN401_03935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AN401_03950	COG1115	amino acid carrier protein
AN401_03955	COG1012	belongs to the aldehyde dehydrogenase family
AN401_03995	COG2199	diguanylate cyclase activity
AN401_04020	COG3657	addiction module killer protein
AN401_04025	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN401_04040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AN401_04045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN401_04050	COG2264	protein methyltransferase activity
AN401_04055	COG4145	pantothenate transmembrane transporter activity
AN401_04060	COG3924	membrane
AN401_04065	COG0251	oxidation-reduction process
AN401_04070	COG0439	Biotin carboxylase
AN401_04075	COG0511	ligase activity, forming carbon-carbon bonds
AN401_04080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AN401_04085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN401_04090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN401_04110	COG1012	belongs to the aldehyde dehydrogenase family
AN401_04125	COG1238	metal cluster binding
AN401_04140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN401_04145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN401_04150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN401_04150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN401_04180	COG3706	GGDEF domain
AN401_04190	COG0400	carboxylic ester hydrolase activity
AN401_04205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AN401_04210	COG1882	Formate acetyltransferase
AN401_04215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AN401_04220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN401_04225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN401_04230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AN401_04235	COG4172	Belongs to the ABC transporter superfamily
AN401_04240	COG0747	negative chemotaxis
AN401_04250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_04270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AN401_04275	COG2840	Smr protein MutS2
AN401_04290	COG0300	oxidoreductase activity
AN401_04330	COG0835	chemotaxis
AN401_04330	COG0784	Response regulator, receiver
AN401_04335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AN401_04340	COG1815	bacterial-type flagellum-dependent cell motility
AN401_04345	COG1558	bacterial-type flagellum-dependent cell motility
AN401_04355	COG1749	Flagellar hook protein flgE
AN401_04360	COG4787	bacterial-type flagellum-dependent cell motility
AN401_04365	COG4786	Flagellar basal body rod
AN401_04370	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AN401_04375	COG1706	bacterial-type flagellum-dependent cell motility
AN401_04380	COG1705	Flagellar rod assembly protein muramidase FlgJ
AN401_04380	COG3951	Flagellar rod assembly protein muramidase FlgJ
AN401_04395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN401_04400	COG1334	flagellar protein FlaG
AN401_04405	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AN401_04415	COG1516	flagellar protein fliS
AN401_04420	COG2204	response regulator
AN401_04425	COG3852	Histidine kinase
AN401_04430	COG2204	response regulator
AN401_04435	COG1677	Flagellar hook-basal body complex protein FliE
AN401_04445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AN401_04495	COG1987	bacterial-type flagellum assembly
AN401_04500	COG1684	flagellar biosynthetic protein fliR
AN401_04520	COG0455	bacterial-type flagellum organization
AN401_04535	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AN401_04540	COG2198	Histidine kinase
AN401_04540	COG0643	Histidine kinase
AN401_04545	COG2201	protein-glutamate methylesterase activity
AN401_04550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN401_04560	COG1192	Involved in chromosome partitioning
AN401_04570	COG0835	chemotaxis
AN401_04580	COG4133	protoheme IX ABC transporter activity
AN401_04585	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN401_04590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN401_04595	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN401_04600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AN401_04605	COG1138	Cytochrome C-type biogenesis protein
AN401_04610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN401_04630	COG1396	sequence-specific DNA binding
AN401_04635	COG3135	benzoate transporter
AN401_04640	COG0513	Belongs to the DEAD box helicase family
AN401_04645	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AN401_04670	COG3098	single-species biofilm formation
AN401_04675	COG0564	pseudouridine synthase activity
AN401_04695	COG3273	potassium ion transport
AN401_04695	COG0471	metal ion transport
AN401_04710	COG0513	Belongs to the DEAD box helicase family
AN401_04715	COG2171	N-acyltransferase activity
AN401_04720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AN401_04725	COG1609	Transcriptional regulator
AN401_04730	COG1263	PTS System
AN401_04730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_04735	COG0366	Alpha amylase catalytic
AN401_04740	COG0393	Putative heavy-metal-binding
AN401_04750	COG1278	Cold shock
AN401_04755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN401_04765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN401_04770	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AN401_04775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AN401_04785	COG0659	secondary active sulfate transmembrane transporter activity
AN401_04790	COG0492	ferredoxin-NADP+ reductase activity
AN401_04800	COG1674	ftsk spoiiie
AN401_04800	COG0531	amino acid
AN401_04805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AN401_04810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN401_04815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN401_04825	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN401_04830	COG1286	toxin biosynthetic process
AN401_04835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN401_04850	COG2267	carboxylic ester hydrolase activity
AN401_04860	COG3300	MHYT domain
AN401_04860	COG5001	Diguanylate cyclase
AN401_04885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AN401_04900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AN401_04905	COG2867	negative regulation of translational initiation
AN401_04915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_04920	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AN401_04925	COG0497	DNA recombination
AN401_04930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN401_04935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN401_04940	COG0443	Heat shock 70 kDa protein
AN401_04945	COG0484	heat shock protein binding
AN401_04950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN401_04960	COG1534	Rna-binding protein
AN401_04965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AN401_04970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN401_04975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AN401_04980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN401_04985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN401_05000	COG0779	Required for maturation of 30S ribosomal subunits
AN401_05005	COG0195	Participates in both transcription termination and antitermination
AN401_05010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN401_05015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN401_05020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN401_05025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AN401_05030	COG3384	dioxygenase
AN401_05035	COG1185	polyribonucleotide nucleotidyltransferase activity
AN401_05045	COG3111	PFAM Bacterial OB fold (BOF) protein
AN401_05050	COG0642	Histidine kinase
AN401_05055	COG0745	RESPONSE REGULATOR receiver
AN401_05065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN401_05080	COG3139	Protein of unknown function (DUF1315)
AN401_05085	COG3272	Protein of unknown function (DUF1722)
AN401_05090	COG0789	Transcriptional regulator
AN401_05095	COG0415	Belongs to the DNA photolyase family
AN401_05105	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_05120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN401_05140	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AN401_05150	COG0788	formyltetrahydrofolate deformylase activity
AN401_05155	COG3012	SEC-C Motif Domain Protein
AN401_05170	COG4783	chaperone-mediated protein folding
AN401_05175	COG1940	carbohydrate kinase activity
AN401_05180	COG0545	Peptidyl-prolyl cis-trans isomerase
AN401_05185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN401_05190	COG0505	Belongs to the CarA family
AN401_05195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AN401_05200	COG1278	Cold shock
AN401_05205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN401_05210	COG1678	Uncharacterized ACR, COG1678
AN401_05215	COG0189	ligase activity
AN401_05220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN401_05230	COG0678	peroxiredoxin activity
AN401_05235	COG3091	SprT-like family
AN401_05240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN401_05245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AN401_05280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AN401_05285	COG2716	regulation of RNA biosynthetic process
AN401_05295	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AN401_05300	COG0417	DNA replication proofreading
AN401_05310	COG1876	peptidase activity
AN401_05315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN401_05320	COG1393	Belongs to the ArsC family
AN401_05325	COG3706	GGDEF domain
AN401_05330	COG0281	malic enzyme
AN401_05335	COG1454	alcohol dehydrogenase
AN401_05335	COG1012	belongs to the aldehyde dehydrogenase family
AN401_05345	COG0601	transmembrane transport
AN401_05350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_05365	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN401_05370	COG0740	serine-type endopeptidase activity
AN401_05375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN401_05380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AN401_05385	COG0776	regulation of translation
AN401_05390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN401_05395	COG2197	response regulator
AN401_05400	COG0322	excinuclease ABC activity
AN401_05405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AN401_05435	COG3284	Transcriptional regulator
AN401_05440	COG1012	belongs to the aldehyde dehydrogenase family
AN401_05445	COG1454	alcohol dehydrogenase
AN401_05460	COG1126	abc transporter atp-binding protein
AN401_05465	COG0765	amino acid transport
AN401_05470	COG4597	amino acid ABC transporter
AN401_05475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_05490	COG3842	ATPase activity
AN401_05560	COG0583	DNA-binding transcription factor activity
AN401_05580	COG1280	lysine exporter protein (LysE YggA)
AN401_05585	COG0840	transmembrane signaling receptor activity
AN401_05590	COG2951	lytic endotransglycosylase activity
AN401_05625	COG0737	Belongs to the 5'-nucleotidase family
AN401_05630	COG1196	nuclear chromosome segregation
AN401_05630	COG3264	Mechanosensitive ion channel
AN401_05635	COG1522	sequence-specific DNA binding
AN401_05645	COG1473	amidohydrolase
AN401_05650	COG2423	ornithine cyclodeaminase activity
AN401_05655	COG0154	amidase activity
AN401_05660	COG1115	amino acid carrier protein
AN401_05685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AN401_05690	COG0372	Belongs to the citrate synthase family
AN401_05695	COG2079	MmgE PrpD family protein
AN401_05710	COG0829	nickel cation binding
AN401_05715	COG0831	urea catabolic process
AN401_05720	COG0832	Belongs to the urease beta subunit family
AN401_05725	COG0804	urea catabolic process
AN401_05735	COG0830	nickel cation binding
AN401_05740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AN401_05750	COG2252	PERMEase
AN401_05755	COG1966	Carbon starvation protein
AN401_05760	COG3279	Response regulator of the LytR AlgR family
AN401_05765	COG3275	phosphorelay sensor kinase activity
AN401_05770	COG0017	Asparaginyl-tRNA synthetase
AN401_05815	COG4964	Belongs to the GSP D family
AN401_05865	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AN401_05880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AN401_05895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN401_05900	COG1946	Acyl-CoA thioesterase
AN401_05905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN401_05915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN401_05920	COG1115	amino acid carrier protein
AN401_05940	COG3132	Protein of unknown function, DUF480
AN401_05980	COG1061	Type III restriction enzyme res subunit
AN401_05995	COG3311	Transcriptional regulator
AN401_06010	COG0159	tryptophan synthase activity
AN401_06015	COG0133	tryptophan synthase activity
AN401_06020	COG0134	indole-3-glycerol-phosphate synthase activity
AN401_06020	COG0135	phosphoribosylanthranilate isomerase activity
AN401_06025	COG0512	Glutamine amidotransferase of anthranilate synthase
AN401_06025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AN401_06030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN401_06040	COG0009	L-threonylcarbamoyladenylate synthase
AN401_06045	COG1187	pseudouridine synthase activity
AN401_06065	COG0500	methyltransferase
AN401_06070	COG4106	trans-aconitate 2-methyltransferase activity
AN401_06075	COG1801	Protein of unknown function DUF72
AN401_06080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN401_06085	COG0494	nUDIX hydrolase
AN401_06095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN401_06100	COG0632	four-way junction helicase activity
AN401_06105	COG2255	four-way junction helicase activity
AN401_06110	COG0824	Thioesterase
AN401_06115	COG0811	peptide transport
AN401_06125	COG3064	Membrane
AN401_06130	COG0823	Involved in the tonB-independent uptake of proteins
AN401_06135	COG2885	chlorophyll binding
AN401_06140	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AN401_06205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AN401_06210	COG2974	May be involved in recombination
AN401_06220	COG0745	RESPONSE REGULATOR receiver
AN401_06225	COG5002	protein histidine kinase activity
AN401_06235	COG0798	PFAM Bile acid sodium symporter
AN401_06265	COG0590	tRNA wobble adenosine to inosine editing
AN401_06270	COG0248	Ppx GppA phosphatase
AN401_06275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN401_06285	COG0573	inorganic phosphate transmembrane transporter activity
AN401_06290	COG0573	inorganic phosphate transmembrane transporter activity
AN401_06300	COG0704	Plays a role in the regulation of phosphate uptake
AN401_06310	COG0673	inositol 2-dehydrogenase activity
AN401_06315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_06320	COG3962	Belongs to the TPP enzyme family
AN401_06345	COG0477	Major facilitator Superfamily
AN401_06350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN401_06355	COG0126	phosphoglycerate kinase activity
AN401_06385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_06410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN401_06425	COG1538	Outer membrane efflux protein
AN401_06460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_06480	COG3585	molybdate ion transport
AN401_06480	COG2005	Transcriptional regulator
AN401_06485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AN401_06500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AN401_06505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AN401_06510	COG4628	conserved protein (DUF2132)
AN401_06525	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AN401_06530	COG3079	Belongs to the UPF0149 family
AN401_06535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_06540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_06545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN401_06550	COG0509	glycine decarboxylation via glycine cleavage system
AN401_06575	COG3360	Dodecin
AN401_06580	COG4565	transcriptional regulatory protein
AN401_06585	COG3290	protein histidine kinase activity
AN401_06590	COG0747	negative chemotaxis
AN401_06610	COG0745	RESPONSE REGULATOR receiver
AN401_06615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AN401_06620	COG1555	photosystem II stabilization
AN401_06625	COG2350	Protein conserved in bacteria
AN401_06630	COG2917	probably involved in intracellular septation
AN401_06640	COG0673	inositol 2-dehydrogenase activity
AN401_06660	COG1129	ABC transporter
AN401_06670	COG0477	Major facilitator Superfamily
AN401_06670	COG2814	Major facilitator Superfamily
AN401_06680	COG1082	Xylose isomerase domain protein TIM barrel
AN401_06685	COG0673	inositol 2-dehydrogenase activity
AN401_06695	COG3718	enzyme involved in inositol metabolism
AN401_06700	COG0673	inositol 2-dehydrogenase activity
AN401_06715	COG3551	Protein conserved in bacteria
AN401_06750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_06760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_06765	COG0583	DNA-binding transcription factor activity
AN401_06770	COG0697	spore germination
AN401_06775	COG1609	Transcriptional regulator
AN401_06780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_06785	COG1879	ABC-type sugar transport system periplasmic component
AN401_06790	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN401_06795	COG1129	ABC transporter
AN401_06800	COG1869	D-ribose catabolic process
AN401_06805	COG0745	RESPONSE REGULATOR receiver
AN401_06805	COG3706	GGDEF domain
AN401_06815	COG4172	Belongs to the ABC transporter superfamily
AN401_06820	COG4172	Belongs to the ABC transporter superfamily
AN401_06825	COG4171	peptide transport system, permease
AN401_06830	COG4168	peptide transport system, permease
AN401_06835	COG4166	transmembrane transport
AN401_06840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AN401_06845	COG1842	Phage shock protein A
AN401_06860	COG3106	COG3106 Predicted ATPase
AN401_06865	COG3768	UPF0283 membrane protein
AN401_06885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN401_06890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_06905	COG0215	cysteine-tRNA ligase activity
AN401_06910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AN401_06915	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_06920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AN401_06945	COG1607	acyl-coa hydrolase
AN401_06950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_06965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN401_06975	COG1012	belongs to the aldehyde dehydrogenase family
AN401_07000	COG3383	formate dehydrogenase (NAD+) activity
AN401_07005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AN401_07140	COG1426	Protein conserved in bacteria
AN401_07210	COG4383	Mu-like prophage protein gp29
AN401_07225	COG4388	Caudovirus prohead serine protease
AN401_07235	COG4397	Mu-like prophage major head subunit gpT
AN401_07305	COG1017	nitric oxide dioxygenase activity
AN401_07305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_07310	COG4638	Rieske (2fe-2S)
AN401_07360	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN401_07360	COG1902	pentaerythritol trinitrate reductase activity
AN401_07365	COG2181	nitrate reductase activity
AN401_07365	COG0247	lactate metabolic process
AN401_07370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN401_07420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN401_07435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_07440	COG0840	transmembrane signaling receptor activity
AN401_07445	COG2116	formate transmembrane transporter activity
AN401_07450	COG2056	Na+-H+ antiporter family
AN401_07455	COG0450	alkyl hydroperoxide reductase
AN401_07470	COG1119	ATPase activity
AN401_07485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN401_07500	COG0583	DNA-binding transcription factor activity
AN401_07530	COG2062	phosphohistidine phosphatase, SixA
AN401_07540	COG2840	Smr protein MutS2
AN401_07545	COG2890	protein-(glutamine-N5) methyltransferase activity
AN401_07550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN401_07555	COG3101	peptidyl-lysine hydroxylation
AN401_07575	COG0175	sulfate reduction
AN401_07580	COG3273	potassium ion transport
AN401_07580	COG0471	metal ion transport
AN401_07585	COG0745	RESPONSE REGULATOR receiver
AN401_07590	COG2132	Multicopper oxidase
AN401_07625	COG2217	Heavy metal translocating P-type atpase
AN401_07630	COG2205	protein histidine kinase activity
AN401_07645	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_07700	COG1595	DNA-templated transcription, initiation
AN401_07710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AN401_07720	COG1609	Transcriptional regulator
AN401_07730	COG0673	inositol 2-dehydrogenase activity
AN401_07735	COG0673	inositol 2-dehydrogenase activity
AN401_07765	COG3622	Belongs to the hyi family
AN401_07775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_07780	COG0473	3-isopropylmalate dehydrogenase activity
AN401_07785	COG3395	kinase activity
AN401_07790	COG0235	Class ii aldolase
AN401_07795	COG0583	DNA-binding transcription factor activity
AN401_07805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_07855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN401_07885	COG1609	Transcriptional regulator
AN401_07895	COG0471	metal ion transport
AN401_07900	COG0583	DNA-binding transcription factor activity
AN401_07905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AN401_07910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AN401_07920	COG1522	sequence-specific DNA binding
AN401_07945	COG1494	fructose-1,6-bisphosphatase
AN401_07950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN401_07955	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AN401_07960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN401_07965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN401_07970	COG1349	DNA-binding transcription factor activity
AN401_07975	COG1879	ABC-type sugar transport system periplasmic component
AN401_07980	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN401_07985	COG1129	ABC transporter
AN401_08010	COG1454	alcohol dehydrogenase
AN401_08020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN401_08030	COG1349	DNA-binding transcription factor activity
AN401_08035	COG0149	triose-phosphate isomerase activity
AN401_08045	COG2376	Dihydroxyacetone kinase
AN401_08050	COG0698	ribose 5-phosphate isomerase
AN401_08055	COG1012	belongs to the aldehyde dehydrogenase family
AN401_08060	COG2186	Transcriptional regulator
AN401_08065	COG3959	Transketolase, thiamine diphosphate binding domain
AN401_08070	COG3958	Transketolase
AN401_08075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_08085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_08090	COG2084	Dehydrogenase
AN401_08100	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_08115	COG2832	Protein of unknown function (DUF454)
AN401_08120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN401_08125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AN401_08130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AN401_08135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN401_08145	COG0295	cytidine deaminase activity
AN401_08150	COG1346	cytolysis
AN401_08155	COG1380	Effector of murein hydrolase LrgA
AN401_08160	COG2925	Exonuclease
AN401_08170	COG1278	Cold shock
AN401_08180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AN401_08185	COG0662	Cupin 2, conserved barrel domain protein
AN401_08190	COG0527	aspartate kinase activity
AN401_08195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN401_08200	COG3593	DNA synthesis involved in DNA repair
AN401_08210	COG2814	Major facilitator Superfamily
AN401_08220	COG3133	Outer membrane lipoprotein
AN401_08230	COG1643	Atp-dependent helicase
AN401_08235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN401_08270	COG1247	-acetyltransferase
AN401_08280	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_08315	COG5433	transposase activity
AN401_08335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN401_08345	COG0789	Transcriptional regulator
AN401_08350	COG2259	Doxx family
AN401_08385	COG0668	transmembrane transport
AN401_08390	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_08400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_08405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_08420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AN401_08425	COG1074	ATP-dependent DNA helicase activity
AN401_08430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN401_08440	COG0590	tRNA wobble adenosine to inosine editing
AN401_08465	COG2205	protein histidine kinase activity
AN401_08465	COG0784	Response regulator, receiver
AN401_08465	COG5002	protein histidine kinase activity
AN401_08470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN401_08480	COG0384	phenazine biosynthesis protein PhzF
AN401_08495	COG2814	Major facilitator Superfamily
AN401_08500	COG0367	asparagine synthase
AN401_08535	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN401_08540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_08555	COG0488	(ABC) transporter
AN401_08560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN401_08565	COG0589	response to stress
AN401_08570	COG0659	secondary active sulfate transmembrane transporter activity
AN401_08580	COG4651	solute:proton antiporter activity
AN401_08580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN401_08595	COG0647	UMP catabolic process
AN401_08600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN401_08610	COG2885	chlorophyll binding
AN401_08615	COG0730	response to heat
AN401_08620	COG1560	Kdo2-lipid A biosynthetic process
AN401_08630	COG4067	protein conserved in archaea
AN401_08630	COG0189	ligase activity
AN401_08635	COG0733	neurotransmitter:sodium symporter activity
AN401_08645	COG0471	metal ion transport
AN401_08650	COG3437	response regulator, receiver
AN401_08650	COG2205	protein histidine kinase activity
AN401_08650	COG4999	Histidine kinase
AN401_08650	COG3850	Histidine kinase
AN401_08655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_08670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_08680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN401_08685	COG1349	DNA-binding transcription factor activity
AN401_08690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN401_08705	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AN401_08720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN401_08755	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AN401_08760	COG0709	Synthesizes selenophosphate from selenide and ATP
AN401_08765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AN401_08770	COG1254	Belongs to the acylphosphatase family
AN401_08780	COG3550	peptidyl-serine autophosphorylation
AN401_08795	COG0494	nUDIX hydrolase
AN401_08800	COG1760	l-serine dehydratase
AN401_08805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN401_08805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN401_08810	COG0837	glucose binding
AN401_08815	COG0745	RESPONSE REGULATOR receiver
AN401_08820	COG2205	protein histidine kinase activity
AN401_08830	COG1175	transmembrane transport
AN401_08835	COG0395	ABC-type sugar transport system, permease component
AN401_08850	COG0572	uridine kinase
AN401_08855	COG0717	Belongs to the dCTP deaminase family
AN401_08870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN401_08875	COG1530	ribonuclease E activity
AN401_08880	COG0564	pseudouridine synthase activity
AN401_08885	COG0546	phosphoglycolate phosphatase activity
AN401_08895	COG1399	metal-binding, possibly nucleic acid-binding protein
AN401_08900	COG0416	fatty acid biosynthetic process
AN401_08905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN401_08915	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_08920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AN401_08930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN401_08935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AN401_08940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN401_08945	COG0470	DNA polymerase III
AN401_08950	COG0084	hydrolase, TatD family'
AN401_08960	COG0330	HflC and HflK could
AN401_08965	COG3141	response to X-ray
AN401_08975	COG1956	GAF domain-containing protein
AN401_08980	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AN401_08990	COG0308	aminopeptidase N
AN401_09000	COG2902	Dehydrogenase
AN401_09005	COG0167	dihydroorotate dehydrogenase activity
AN401_09035	COG0116	Belongs to the methyltransferase superfamily
AN401_09035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AN401_09050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN401_09055	COG1067	ATP-dependent peptidase activity
AN401_09060	COG0671	phosphoesterase, PA-phosphatase related
AN401_09080	COG0011	TIGRFAM Protein of
AN401_09090	COG4804	nuclease activity
AN401_09110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AN401_09130	COG4974	Belongs to the 'phage' integrase family
AN401_09135	COG0318	PFAM AMP-dependent synthetase and ligase
AN401_09180	COG0022	dehydrogenase e1 component
AN401_09185	COG1063	alcohol dehydrogenase
AN401_09190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AN401_09195	COG3284	Transcriptional regulator
AN401_09205	COG3278	Belongs to the heme-copper respiratory oxidase family
AN401_09220	COG2010	Cytochrome c
AN401_09230	COG2217	Heavy metal translocating P-type atpase
AN401_09245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_09255	COG0037	tRNA processing
AN401_09270	COG3842	ATPase activity
AN401_09275	COG1176	ABC-type spermidine putrescine transport system, permease component I
AN401_09280	COG1177	transmembrane transport
AN401_09285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN401_09290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN401_09295	COG0776	regulation of translation
AN401_09305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AN401_09310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AN401_09315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN401_09320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AN401_09325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN401_09340	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_09350	COG0307	riboflavin synthase, alpha
AN401_09385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AN401_09390	COG2766	serine protein kinase
AN401_09395	COG2718	Belongs to the UPF0229 family
AN401_09400	COG2719	SpoVR family
AN401_09410	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AN401_09420	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN401_09425	COG3100	YcgL domain-containing protein
AN401_09430	COG0850	regulation of cytokinetic process
AN401_09435	COG2894	cell division
AN401_09440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AN401_09445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AN401_09450	COG0318	PFAM AMP-dependent synthetase and ligase
AN401_09460	COG1199	ATP-dependent helicase activity
AN401_09515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN401_09520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN401_09525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN401_09530	COG0131	Imidazoleglycerol-phosphate dehydratase
AN401_09530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AN401_09535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN401_09540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN401_09545	COG0107	imidazoleglycerol-phosphate synthase activity
AN401_09550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AN401_09550	COG0140	phosphoribosyl-ATP diphosphatase activity
AN401_09560	COG2814	Major facilitator Superfamily
AN401_09565	COG1448	Aminotransferase
AN401_09595	COG2995	paraquat-inducible protein a
AN401_09600	COG3008	intermembrane lipid transfer
AN401_09600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN401_09615	COG0697	spore germination
AN401_09640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN401_09640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_09650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN401_09665	COG0840	transmembrane signaling receptor activity
AN401_09670	COG0456	acetyltransferase
AN401_09690	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AN401_09695	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AN401_09700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN401_09705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AN401_09715	COG0205	6-phosphofructokinase activity
AN401_09730	COG2878	Part of a membrane complex involved in electron transport
AN401_09735	COG4656	Part of a membrane complex involved in electron transport
AN401_09740	COG4658	electron transport chain
AN401_09750	COG4660	Part of a membrane complex involved in electron transport
AN401_09755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AN401_09775	COG0346	lactoylglutathione lyase activity
AN401_09795	COG2814	Major facilitator Superfamily
AN401_09800	COG0583	DNA-binding transcription factor activity
AN401_09810	COG1136	(ABC) transporter
AN401_09825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN401_09840	COG1199	ATP-dependent helicase activity
AN401_09845	COG0730	response to heat
AN401_09850	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AN401_09865	COG0500	methyltransferase
AN401_09880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN401_09885	COG0563	adenylate kinase activity
AN401_09890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN401_09895	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AN401_09900	COG0326	Molecular chaperone. Has ATPase activity
AN401_09910	COG0183	Belongs to the thiolase family
AN401_09925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_09930	COG2067	long-chain fatty acid transport protein
AN401_09935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AN401_09945	COG1757	Na H antiporter
AN401_09965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AN401_09970	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AN401_09975	COG0776	regulation of translation
AN401_09980	COG0539	negative regulation of cytoplasmic translation
AN401_09985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AN401_09990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN401_10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN401_10005	COG0022	dehydrogenase e1 component
AN401_10010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AN401_10015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN401_10045	COG0375	protein maturation
AN401_10050	COG0309	Hydrogenase expression formation protein (HypE)
AN401_10055	COG0409	Hydrogenase expression formation protein
AN401_10070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN401_10070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AN401_10070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN401_10075	COG1105	Belongs to the carbohydrate kinase PfkB family
AN401_10080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN401_10080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_10085	COG1609	Transcriptional regulator
AN401_10095	COG0564	pseudouridine synthase activity
AN401_10105	COG0670	Belongs to the BI1 family
AN401_10110	COG1289	transmembrane transporter activity
AN401_10115	COG2920	part of a sulfur-relay system
AN401_10120	COG3850	Histidine kinase
AN401_10125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AN401_10135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN401_10140	COG1737	Transcriptional regulator
AN401_10145	COG0469	pyruvate kinase activity
AN401_10160	COG1166	arginine decarboxylase activity
AN401_10165	COG4667	esterase of the alpha-beta hydrolase superfamily
AN401_10190	COG0583	DNA-binding transcription factor activity
AN401_10195	COG0302	gtp cyclohydrolase
AN401_10200	COG0303	'Molybdopterin
AN401_10205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN401_10210	COG0602	queuosine metabolic process
AN401_10215	COG0720	synthase
AN401_10220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AN401_10225	COG0574	Belongs to the PEP-utilizing enzyme family
AN401_10225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN401_10230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AN401_10240	COG3833	ABC-type maltose transport systems, permease component
AN401_10245	COG1175	transmembrane transport
AN401_10260	COG0366	Alpha amylase catalytic
AN401_10270	COG4580	involved in the transport of maltose and maltodextrins
AN401_10280	COG2909	trisaccharide binding
AN401_10290	COG3833	ABC-type maltose transport systems, permease component
AN401_10295	COG1175	transmembrane transport
AN401_10300	COG2182	Extracellular solute-binding protein
AN401_10305	COG3842	ATPase activity
AN401_10310	COG0366	Alpha amylase catalytic
AN401_10320	COG1609	Transcriptional regulator
AN401_10335	COG3123	guanosine phosphorylase activity
AN401_10340	COG0366	Alpha amylase catalytic
AN401_10345	COG0366	Alpha amylase catalytic
AN401_10350	COG3842	ATPase activity
AN401_10370	COG1653	transport
AN401_10375	COG0583	DNA-binding transcription factor activity
AN401_10380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_10380	COG1263	PTS System
AN401_10390	COG2308	Evidence 4 Homologs of previously reported genes of
AN401_10410	COG2133	pyrroloquinoline quinone binding
AN401_10420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_10425	COG3263	regulation of cellular component size
AN401_10430	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN401_10455	COG1492	cobalamin metabolic process
AN401_10460	COG5507	3-demethylubiquinone-9 3-methyltransferase
AN401_10465	COG3795	YCII-related domain
AN401_10470	COG3795	YCII-related domain
AN401_10475	COG4941	Belongs to the sigma-70 factor family
AN401_10480	COG1283	sodium-dependent phosphate transmembrane transporter activity
AN401_10495	COG1522	sequence-specific DNA binding
AN401_10505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_10515	COG0693	protein deglycase activity
AN401_10520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AN401_10525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AN401_10540	COG3300	MHYT domain
AN401_10540	COG5001	Diguanylate cyclase
AN401_10545	COG1309	transcriptional regulator
AN401_10550	COG0625	glutathione transferase activity
AN401_10575	COG1881	PFAM PEBP family protein
AN401_10605	COG1793	dna ligase
AN401_10610	COG2807	transmembrane transport
AN401_10615	COG0746	molybdenum cofactor guanylyltransferase activity
AN401_10620	COG0778	Nitroreductase
AN401_10625	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN401_10625	COG1902	pentaerythritol trinitrate reductase activity
AN401_10630	COG0616	signal peptide processing
AN401_10635	COG0252	asparaginase activity
AN401_10645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN401_10650	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AN401_10660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN401_10670	COG4139	cobalamin transport
AN401_10675	COG0583	DNA-binding transcription factor activity
AN401_10680	COG0730	response to heat
AN401_10685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN401_10690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN401_10700	COG0189	ligase activity
AN401_10725	COG0667	Aldo Keto reductase
AN401_10730	COG0402	S-adenosylhomocysteine deaminase activity
AN401_10780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN401_10795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_10795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AN401_10810	COG4638	Rieske (2fe-2S)
AN401_10815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN401_10820	COG0583	DNA-binding transcription factor activity
AN401_10830	COG0405	Gamma-glutamyltransferase
AN401_10835	COG2807	transmembrane transport
AN401_10845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_10850	COG1120	ATPase activity
AN401_10860	COG0583	DNA-binding transcription factor activity
AN401_10865	COG0513	Belongs to the DEAD box helicase family
AN401_10880	COG2957	Belongs to the agmatine deiminase family
AN401_10890	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AN401_10895	COG0285	dihydrofolate synthase activity
AN401_10900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AN401_10905	COG0101	tRNA pseudouridine synthase activity
AN401_10915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_10920	COG0671	phosphoesterase, PA-phosphatase related
AN401_10925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN401_10930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_10930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AN401_10960	COG0556	nucleotide-excision repair
AN401_10970	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN401_10985	COG3299	homolog of phage Mu protein gp47
AN401_10995	COG4384	Bacteriophage Mu Gp45 protein
AN401_11005	COG4228	DNA circulation
AN401_11015	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
AN401_11105	COG4382	Mu-like prophage protein Gp16
AN401_11185	COG2190	(PTS) system
AN401_11185	COG1263	PTS System
AN401_11185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_11190	COG0363	glucosamine-6-phosphate deaminase activity
AN401_11195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AN401_11200	COG1846	Transcriptional regulator
AN401_11200	COG1940	carbohydrate kinase activity
AN401_11205	COG0023	Translation Initiation Factor
AN401_11210	COG2119	membrane
AN401_11220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN401_11220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AN401_11225	COG0527	aspartate kinase activity
AN401_11230	COG3174	membrane
AN401_11235	COG0625	glutathione transferase activity
AN401_11240	COG0505	Belongs to the CarA family
AN401_11245	COG0686	Belongs to the AlaDH PNT family
AN401_11260	COG1177	transmembrane transport
AN401_11265	COG1176	ABC-type spermidine putrescine transport system, permease component I
AN401_11270	COG3842	ATPase activity
AN401_11275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN401_11285	COG0174	glutamine synthetase
AN401_11290	COG0174	glutamine synthetase
AN401_11295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_11300	COG3313	Fe-S protein
AN401_11310	COG0314	molybdopterin synthase activity
AN401_11315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AN401_11320	COG0315	cyclic pyranopterin monophosphate synthase activity
AN401_11325	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN401_11330	COG3005	denitrification pathway
AN401_11340	COG0348	domain, Protein
AN401_11345	COG0437	4 iron, 4 sulfur cluster binding
AN401_11350	COG0243	molybdopterin cofactor binding
AN401_11360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN401_11365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN401_11370	COG2197	response regulator
AN401_11380	COG2204	response regulator
AN401_11385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN401_11410	COG0840	transmembrane signaling receptor activity
AN401_11420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN401_11425	COG3724	N-succinylarginine dihydrolase activity
AN401_11430	COG0616	signal peptide processing
AN401_11435	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_11440	COG0583	DNA-binding transcription factor activity
AN401_11445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AN401_11485	COG2988	succinylglutamate desuccinylase activity
AN401_11490	COG0033	Phosphoglucomutase
AN401_11495	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AN401_11500	COG0596	Alpha beta hydrolase
AN401_11515	COG0716	FMN binding
AN401_11520	COG1376	ErfK ybiS ycfS ynhG family protein
AN401_11630	COG4382	Mu-like prophage protein Gp16
AN401_11635	COG5566	PFAM Mor transcription activator
AN401_11660	COG0640	Transcriptional regulator
AN401_11675	COG4383	Mu-like prophage protein gp29
AN401_11680	COG2369	cell adhesion
AN401_11700	COG4388	Caudovirus prohead serine protease
AN401_11710	COG4397	Mu-like prophage major head subunit gpT
AN401_11720	COG4387	Mu-like prophage protein GP36
AN401_11725	COG5003	unkown
AN401_11735	COG4386	tail sheath protein
AN401_11745	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
AN401_11755	COG4228	DNA circulation
AN401_11765	COG4384	Bacteriophage Mu Gp45 protein
AN401_11775	COG3299	homolog of phage Mu protein gp47
AN401_11790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN401_11805	COG4964	Belongs to the GSP D family
AN401_11845	COG0735	belongs to the Fur family
AN401_11850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN401_11910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN401_11915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN401_11920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN401_11930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN401_11935	COG0546	phosphoglycolate phosphatase activity
AN401_11940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN401_11945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN401_11950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_11980	COG4691	Plasmid stability protein
AN401_11985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN401_12045	COG4691	Plasmid stability protein
AN401_12080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN401_12085	COG1074	ATP-dependent DNA helicase activity
AN401_12090	COG0582	viral genome integration into host DNA
AN401_12095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN401_12095	COG0519	Catalyzes the synthesis of GMP from XMP
AN401_12100	COG0516	GMP reductase activity
AN401_12100	COG0517	IMP dehydrogenase activity
AN401_12105	COG1570	exodeoxyribonuclease VII activity
AN401_12125	COG0045	succinate-CoA ligase (ADP-forming) activity
AN401_12130	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN401_12135	COG0567	Dehydrogenase, E1 component
AN401_12140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN401_12145	COG1053	succinate dehydrogenase
AN401_12150	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AN401_12155	COG2009	succinate dehydrogenase
AN401_12165	COG0071	Belongs to the small heat shock protein (HSP20) family
AN401_12170	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AN401_12175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AN401_12180	COG2835	tetraacyldisaccharide 4'-kinase activity
AN401_12185	COG1663	tetraacyldisaccharide 4'-kinase activity
AN401_12195	COG0658	competence protein
AN401_12195	COG2333	competence protein COMEC
AN401_12210	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN401_12215	COG1136	(ABC) transporter
AN401_12220	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN401_12230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AN401_12260	COG0513	Belongs to the DEAD box helicase family
AN401_12270	COG1252	NADH dehydrogenase
AN401_12275	COG1472	Belongs to the glycosyl hydrolase 3 family
AN401_12290	COG0537	adenosine 5'-monophosphoramidase activity
AN401_12295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN401_12340	COG0840	transmembrane signaling receptor activity
AN401_12355	COG0729	surface antigen
AN401_12360	COG1763	Mo-molybdopterin cofactor biosynthetic process
AN401_12375	COG1132	(ABC) transporter
AN401_12380	COG1132	(ABC) transporter
AN401_12395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AN401_12400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AN401_12410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN401_12450	COG0501	Belongs to the peptidase M48B family
AN401_12455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AN401_12465	COG0156	8-amino-7-oxononanoate synthase activity
AN401_12470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN401_12490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_12500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_12515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_12520	COG0625	glutathione transferase activity
AN401_12530	COG0583	DNA-binding transcription factor activity
AN401_12535	COG0583	DNA-binding transcription factor activity
AN401_12540	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN401_12545	COG1473	amidohydrolase
AN401_12580	COG3327	negative regulation of DNA-templated transcription, initiation
AN401_12585	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AN401_12590	COG0183	Belongs to the thiolase family
AN401_12595	COG2050	protein possibly involved in aromatic compounds catabolism
AN401_12600	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN401_12605	COG1024	Enoyl-CoA hydratase
AN401_12610	COG1024	Enoyl-CoA hydratase
AN401_12615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_12620	COG2151	metal-sulfur cluster biosynthetic enzyme
AN401_12625	COG3396	Phenylacetate-CoA oxygenase
AN401_12630	COG3460	Phenylacetate-CoA oxygenase
AN401_12635	COG3396	Phenylacetate-CoA oxygenase
AN401_12640	COG1012	belongs to the aldehyde dehydrogenase family
AN401_12640	COG2030	dehydratase
AN401_12645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_12650	COG0745	RESPONSE REGULATOR receiver
AN401_12665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AN401_12675	COG1086	Polysaccharide biosynthesis protein
AN401_12680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN401_12690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN401_12715	COG1086	Polysaccharide biosynthesis protein
AN401_12740	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AN401_12765	COG1720	tRNA m6t6A37 methyltransferase activity
AN401_12780	COG0037	tRNA processing
AN401_12785	COG3706	GGDEF domain
AN401_12790	COG0825	malonyl-CoA metabolic process
AN401_12795	COG0587	DNA-directed DNA polymerase activity
AN401_12800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN401_12805	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_12810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_12815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN401_12820	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_12825	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AN401_12830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_12835	COG0750	zinc metalloprotease
AN401_12840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN401_12845	COG0575	Belongs to the CDS family
AN401_12855	COG0233	cytoplasmic translational termination
AN401_12860	COG0528	UMP kinase activity
AN401_12865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN401_12870	COG0052	Belongs to the universal ribosomal protein uS2 family
AN401_12875	COG0024	Methionine aminopeptidase
AN401_12880	COG0538	isocitrate dehydrogenase activity
AN401_12885	COG1187	pseudouridine synthase activity
AN401_12895	COG0482	sulfurtransferase activity
AN401_12900	COG2915	High frequency lysogenization protein hflD homolog
AN401_12905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN401_12910	COG2850	peptidyl-arginine hydroxylation
AN401_12915	COG3153	acetyltransferase
AN401_12920	COG0259	pyridoxamine-phosphate oxidase activity
AN401_12925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN401_12930	COG2814	Major facilitator Superfamily
AN401_12940	COG0483	inositol monophosphate 1-phosphatase activity
AN401_12955	COG0277	FAD linked oxidase domain protein
AN401_12955	COG0247	lactate metabolic process
AN401_12965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN401_12970	COG1187	pseudouridine synthase activity
AN401_12990	COG3279	Response regulator of the LytR AlgR family
AN401_12995	COG3706	GGDEF domain
AN401_13010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AN401_13015	COG1061	Type III restriction enzyme res subunit
AN401_13020	COG2027	D-alanyl-D-alanine carboxypeptidase
AN401_13025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AN401_13030	COG0436	Aminotransferase
AN401_13055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AN401_13065	COG1160	GTP binding
AN401_13070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_13075	COG2976	Protein conserved in bacteria
AN401_13080	COG0124	histidyl-tRNA synthetase
AN401_13100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN401_13105	COG0105	UTP biosynthetic process
AN401_13120	COG2975	iron-sulfur cluster assembly
AN401_13130	COG0443	Heat shock 70 kDa protein
AN401_13135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AN401_13140	COG0316	Belongs to the HesB IscA family
AN401_13145	COG0822	iron-sulfur transferase activity
AN401_13150	COG1104	cysteine desulfurase activity
AN401_13185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN401_13190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN401_13195	COG1862	Preprotein translocase
AN401_13200	COG0343	queuine tRNA-ribosyltransferase activity
AN401_13205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AN401_13210	COG0517	IMP dehydrogenase activity
AN401_13220	COG0515	serine threonine protein kinase
AN401_13230	COG0022	dehydrogenase e1 component
AN401_13250	COG0450	alkyl hydroperoxide reductase
AN401_13255	COG3634	alkyl hydroperoxide reductase activity
AN401_13260	COG0583	DNA-binding transcription factor activity
AN401_13265	COG3081	Nucleoid-associated protein
AN401_13280	COG0791	NLP P60 protein
AN401_13295	COG0733	neurotransmitter:sodium symporter activity
AN401_13305	COG0425	Belongs to the sulfur carrier protein TusA family
AN401_13310	COG4783	chaperone-mediated protein folding
AN401_13320	COG1393	Belongs to the ArsC family
AN401_13330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN401_13340	COG2233	PERMEase
AN401_13345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AN401_13350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN401_13355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN401_13365	COG1067	ATP-dependent peptidase activity
AN401_13370	COG0121	glutamine amidotransferase
AN401_13385	COG1960	acyl-CoA dehydrogenase activity
AN401_13390	COG1120	ATPase activity
AN401_13395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_13400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_13410	COG2207	Transcriptional regulator
AN401_13410	COG3708	Transcriptional regulator
AN401_13430	COG0456	acetyltransferase
AN401_13430	COG0454	-acetyltransferase
AN401_13450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_13455	COG0765	amino acid transport
AN401_13460	COG1126	abc transporter atp-binding protein
AN401_13465	COG2040	homocysteine
AN401_13470	COG1522	sequence-specific DNA binding
AN401_13480	COG2912	Transglutaminase-like superfamily
AN401_13485	COG2890	protein-(glutamine-N5) methyltransferase activity
AN401_13490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN401_13495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AN401_13500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AN401_13505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN401_13510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AN401_13515	COG0730	response to heat
AN401_13520	COG0193	aminoacyl-tRNA hydrolase activity
AN401_13525	COG0012	GTP binding
AN401_13560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_13565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN401_13570	COG1702	phosphate starvation-inducible protein PhoH
AN401_13575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AN401_13580	COG4535	Mg2 and Co2 transporter CorC
AN401_13585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AN401_13590	COG2888	peptidyl-tyrosine sulfation
AN401_13595	COG0495	leucyl-tRNA aminoacylation
AN401_13600	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AN401_13605	COG1466	dna polymerase III delta subunit
AN401_13610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN401_13615	COG0799	negative regulation of ribosome biogenesis
AN401_13620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AN401_13625	COG0768	penicillin binding
AN401_13630	COG0772	Belongs to the SEDS family
AN401_13635	COG2951	lytic endotransglycosylase activity
AN401_13640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN401_13645	COG1686	Belongs to the peptidase S11 family
AN401_13650	COG2921	Belongs to the UPF0250 family
AN401_13655	COG0321	lipoyl(octanoyl) transferase activity
AN401_13660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN401_13665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN401_13680	COG1671	Belongs to the UPF0178 family
AN401_13695	COG4232	protein-disulfide reductase activity
AN401_13700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN401_13710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AN401_13715	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AN401_13730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AN401_13735	COG0840	transmembrane signaling receptor activity
AN401_13740	COG2195	Cleaves the N-terminal amino acid of tripeptides
AN401_13750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AN401_13755	COG2991	Protein conserved in bacteria
AN401_13760	COG1477	protein flavinylation
AN401_13765	COG2871	sodium ion transport
AN401_13775	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN401_13780	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN401_13785	COG1805	sodium ion transport
AN401_13795	COG0271	Belongs to the BolA IbaG family
AN401_13805	COG2813	Specifically methylates the guanine in position
AN401_13820	COG2211	Major facilitator Superfamily
AN401_13825	COG3248	Nucleoside-binding outer membrane protein
AN401_13830	COG1666	GTP binding
AN401_13835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AN401_13840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_13840	COG0301	tRNA thio-modification
AN401_13845	COG1360	Flagellar Motor Protein
AN401_13850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN401_13860	COG0142	geranyltranstransferase activity
AN401_13865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN401_13870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN401_13890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_13905	COG0708	Exodeoxyribonuclease III
AN401_13915	COG4215	(ABC) transporter
AN401_13930	COG2431	L-lysine efflux transmembrane transporter activity
AN401_13935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_13935	COG2213	PTS system mannitol-specific
AN401_13940	COG0246	Mannitol dehydrogenase
AN401_13945	COG3722	fumarate hydratase activity
AN401_13950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AN401_13955	COG1944	ATP diphosphatase activity
AN401_13985	COG4191	Histidine kinase
AN401_13995	COG1959	2 iron, 2 sulfur cluster binding
AN401_14015	COG2205	protein histidine kinase activity
AN401_14015	COG2198	Histidine kinase
AN401_14015	COG0784	Response regulator, receiver
AN401_14020	COG2814	Major facilitator Superfamily
AN401_14035	COG5001	Diguanylate cyclase
AN401_14050	COG0584	glycerophosphoryl diester phosphodiesterase
AN401_14055	COG0583	DNA-binding transcription factor activity
AN401_14060	COG2828	Protein conserved in bacteria
AN401_14075	COG1049	propionate catabolic process, 2-methylcitrate cycle
AN401_14090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN401_14090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN401_14100	COG2199	diguanylate cyclase activity
AN401_14105	COG1611	Belongs to the LOG family
AN401_14110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN401_14115	COG0473	3-isopropylmalate dehydrogenase activity
AN401_14125	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AN401_14130	COG2363	Small membrane protein
AN401_14140	COG0583	DNA-binding transcription factor activity
AN401_14165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN401_14215	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AN401_14235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN401_14240	COG0328	RNA-DNA hybrid ribonuclease activity
AN401_14245	COG2226	methyltransferase
AN401_14250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN401_14255	COG1388	LysM domain
AN401_14255	COG0741	lytic transglycosylase activity
AN401_14260	COG1607	acyl-coa hydrolase
AN401_14265	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AN401_14270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN401_14280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN401_14285	COG0077	Prephenate dehydratase
AN401_14285	COG1605	Chorismate mutase
AN401_14290	COG0287	Prephenate dehydrogenase
AN401_14290	COG1605	Chorismate mutase
AN401_14295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN401_14310	COG1125	glycine betaine transport
AN401_14310	COG0517	IMP dehydrogenase activity
AN401_14315	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AN401_14320	COG0811	peptide transport
AN401_14325	COG0848	biopolymer transport protein
AN401_14360	COG0028	Belongs to the TPP enzyme family
AN401_14375	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_14390	COG2271	Major facilitator Superfamily
AN401_14405	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_14430	COG1082	Xylose isomerase domain protein TIM barrel
AN401_14440	COG0488	(ABC) transporter
AN401_14455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN401_14470	COG0583	DNA-binding transcription factor activity
AN401_14475	COG2056	Na+-H+ antiporter family
AN401_14500	COG1960	acyl-CoA dehydrogenase activity
AN401_14515	COG0733	neurotransmitter:sodium symporter activity
AN401_14520	COG3844	kynureninase activity
AN401_14525	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AN401_14530	COG3483	tryptophan 2,3-dioxygenase activity
AN401_14565	COG2207	Transcriptional regulator
AN401_14570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_14570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_14580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_14625	COG0543	2 iron, 2 sulfur cluster binding
AN401_14625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_14630	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AN401_14635	COG4638	Rieske (2fe-2S)
AN401_14650	COG1017	nitric oxide dioxygenase activity
AN401_14650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_14655	COG2301	Belongs to the HpcH HpaI aldolase family
AN401_14675	COG0741	lytic transglycosylase activity
AN401_14675	COG1388	LysM domain
AN401_14685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN401_14690	COG1191	sigma factor activity
AN401_14715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AN401_14720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN401_14735	COG1256	bacterial-type flagellum assembly
AN401_14745	COG1706	bacterial-type flagellum-dependent cell motility
AN401_14750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AN401_14755	COG4786	Flagellar basal body rod
AN401_14760	COG4787	bacterial-type flagellum-dependent cell motility
AN401_14765	COG1749	Flagellar hook protein flgE
AN401_14770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AN401_14775	COG1558	bacterial-type flagellum-dependent cell motility
AN401_14780	COG1815	bacterial-type flagellum-dependent cell motility
AN401_14825	COG1677	Flagellar hook-basal body complex protein FliE
AN401_14830	COG2204	response regulator
AN401_14855	COG1987	bacterial-type flagellum assembly
AN401_14890	COG0651	ATP synthesis coupled electron transport
AN401_14895	COG0651	ATP synthesis coupled electron transport
AN401_14915	COG1320	monovalent cation:proton antiporter activity
AN401_14930	COG0789	Transcriptional regulator
AN401_14945	COG1012	belongs to the aldehyde dehydrogenase family
AN401_14955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AN401_14965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_14980	COG0138	bifunctional purine biosynthesis protein purh
AN401_14985	COG0151	Belongs to the GarS family
AN401_15000	COG0776	regulation of translation
AN401_15005	COG2084	Dehydrogenase
AN401_15015	COG1012	belongs to the aldehyde dehydrogenase family
AN401_15020	COG3138	arginine N-succinyltransferase
AN401_15025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN401_15045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN401_15050	COG2201	protein-glutamate methylesterase activity
AN401_15055	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AN401_15065	COG0840	transmembrane signaling receptor activity
AN401_15070	COG0835	chemotaxis
AN401_15080	COG2198	Histidine kinase
AN401_15080	COG0643	Histidine kinase
AN401_15090	COG0745	RESPONSE REGULATOR receiver
AN401_15095	COG0840	transmembrane signaling receptor activity
AN401_15120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AN401_15130	COG2154	pterin-4-alpha-carbinolamine dehydratase
AN401_15140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_15145	COG1012	belongs to the aldehyde dehydrogenase family
AN401_15150	COG1917	Cupin 2, conserved barrel domain protein
AN401_15150	COG1396	sequence-specific DNA binding
AN401_15155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN401_15160	COG0174	glutamine synthetase
AN401_15165	COG1757	Na H antiporter
AN401_15170	COG2897	thiosulfate sulfurtransferase activity
AN401_15175	COG2391	methyltransferase activity
AN401_15180	COG1294	oxidase, subunit
AN401_15185	COG1271	oxidase subunit
AN401_15190	COG4191	Histidine kinase
AN401_15195	COG2204	response regulator
AN401_15205	COG0733	neurotransmitter:sodium symporter activity
AN401_15215	COG1522	sequence-specific DNA binding
AN401_15220	COG4608	Belongs to the ABC transporter superfamily
AN401_15225	COG0444	Belongs to the ABC transporter superfamily
AN401_15230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_15240	COG0747	negative chemotaxis
AN401_15250	COG0402	S-adenosylhomocysteine deaminase activity
AN401_15265	COG0210	DNA helicase
AN401_15270	COG1522	sequence-specific DNA binding
AN401_15275	COG0531	amino acid
AN401_15280	COG3706	GGDEF domain
AN401_15280	COG0745	RESPONSE REGULATOR receiver
AN401_15290	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AN401_15295	COG0583	DNA-binding transcription factor activity
AN401_15305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_15310	COG0433	COG0433 Predicted ATPase
AN401_15315	COG2193	ferroxidase activity
AN401_15325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN401_15330	COG1609	Transcriptional regulator
AN401_15335	COG2723	6-phospho-beta-galactosidase activity
AN401_15350	COG1132	(ABC) transporter
AN401_15385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN401_15405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AN401_15415	COG0625	glutathione transferase activity
AN401_15420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN401_15440	COG0546	phosphoglycolate phosphatase activity
AN401_15445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN401_15450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AN401_15460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AN401_15465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AN401_15495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AN401_15505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_15515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN401_15550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AN401_15555	COG3596	GTP binding
AN401_15560	COG0735	belongs to the Fur family
AN401_15570	COG0385	Bile acid
AN401_15575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN401_15580	COG0305	Participates in initiation and elongation during chromosome replication
AN401_15595	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AN401_15600	COG0511	ligase activity, forming carbon-carbon bonds
AN401_15600	COG5016	pyruvate
AN401_15630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AN401_15635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN401_15645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN401_15650	COG1546	Belongs to the CinA family
AN401_15655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AN401_15660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN401_15665	COG1388	LysM domain
AN401_15665	COG4942	peptidase
AN401_15675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AN401_15680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AN401_15685	COG0585	pseudouridine synthase activity
AN401_15695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN401_15700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AN401_15710	COG0504	CTP synthase activity
AN401_15730	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_15740	COG1024	Enoyl-CoA hydratase
AN401_15750	COG1960	acyl-CoA dehydrogenase activity
AN401_15765	COG1960	acyl-CoA dehydrogenase activity
AN401_15770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN401_15790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_15795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_15800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_15805	COG3265	gluconokinase activity
AN401_15815	COG0800	Aldolase
AN401_15820	COG1609	Transcriptional regulator
AN401_15825	COG0166	Belongs to the GPI family
AN401_15830	COG0039	L-malate dehydrogenase activity
AN401_15835	COG4160	amino acid transport
AN401_15840	COG4215	(ABC) transporter
AN401_15845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_15850	COG1126	abc transporter atp-binding protein
AN401_15855	COG1438	arginine binding
AN401_15860	COG2837	iron assimilation
AN401_15865	COG3842	ATPase activity
AN401_15875	COG1840	ABC-type Fe3 transport system, periplasmic component
AN401_15880	COG0004	ammonium transporteR
AN401_15890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN401_15900	COG1049	propionate catabolic process, 2-methylcitrate cycle
AN401_15915	COG0840	transmembrane signaling receptor activity
AN401_15920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_15925	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN401_15930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN401_15935	COG2186	Transcriptional regulator
AN401_15945	COG3577	Aspartyl protease
AN401_15960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN401_15965	COG1459	type II secretion system
AN401_15980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN401_15985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_15990	COG1194	a g-specific adenine glycosylase
AN401_15995	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AN401_16025	COG1278	Cold shock
AN401_16040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN401_16045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN401_16050	COG2813	Specifically methylates the guanine in position
AN401_16085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN401_16100	COG0795	lipopolysaccharide-transporting ATPase activity
AN401_16105	COG0795	lipopolysaccharide-transporting ATPase activity
AN401_16110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN401_16115	COG2927	DNA polymerase III (CHI subunit)
AN401_16120	COG0525	valine-tRNA ligase activity
AN401_16135	COG2885	chlorophyll binding
AN401_16145	COG2169	Transcriptional regulator
AN401_16145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN401_16155	COG0252	asparaginase activity
AN401_16160	COG1027	Aspartate ammonia-lyase
AN401_16185	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AN401_16190	COG0204	Acyl-transferase
AN401_16200	COG0653	protein targeting
AN401_16210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AN401_16215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN401_16220	COG0849	cell division
AN401_16225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AN401_16230	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN401_16235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN401_16240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN401_16245	COG0772	Belongs to the SEDS family
AN401_16250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN401_16255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN401_16260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN401_16265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN401_16270	COG0768	penicillin binding
AN401_16275	COG3116	cell division
AN401_16280	COG0275	rRNA processing
AN401_16285	COG2001	Belongs to the MraZ family
AN401_16290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AN401_16295	COG3107	peptidoglycan biosynthetic process
AN401_16300	COG0792	nuclease activity
AN401_16305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AN401_16310	COG2823	Periplasmic or secreted lipoprotein
AN401_16315	COG2969	positive regulation of protein catabolic process
AN401_16320	COG0625	glutathione transferase activity
AN401_16325	COG2857	Cytochrome c1
AN401_16330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AN401_16335	COG0723	plastoquinol--plastocyanin reductase activity
AN401_16340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN401_16345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN401_16350	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN401_16355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN401_16360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN401_16365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN401_16370	COG5007	Belongs to the BolA IbaG family
AN401_16380	COG2854	intermembrane phospholipid transfer
AN401_16385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN401_16390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN401_16395	COG1127	ABC transporter
AN401_16405	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AN401_16415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AN401_16420	COG1137	ATPase activity
AN401_16425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AN401_16435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_16440	COG1660	Displays ATPase and GTPase activities
AN401_16445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_16450	COG2239	Acts as a magnesium transporter
AN401_16455	COG0312	modulator of DNA gyrase
AN401_16460	COG3028	Belongs to the UPF0307 family
AN401_16470	COG0312	modulator of DNA gyrase
AN401_16475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_16485	COG1530	ribonuclease E activity
AN401_16495	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AN401_16500	COG1792	Involved in formation and maintenance of cell shape
AN401_16505	COG1077	Cell shape determining protein MreB Mrl
AN401_16510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AN401_16515	COG2199	diguanylate cyclase activity
AN401_16515	COG2200	EAL domain
AN401_16525	COG2814	Major facilitator Superfamily
AN401_16530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AN401_16545	COG0390	transport system, permease component
AN401_16575	COG1127	ABC transporter
AN401_16580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN401_16590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN401_16595	COG1686	Belongs to the peptidase S11 family
AN401_16600	COG1410	methionine synthase
AN401_16600	COG0646	methionine synthase
AN401_16610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AN401_16615	COG1546	Belongs to the CinA family
AN401_16615	COG1058	Belongs to the CinA family
AN401_16630	COG2233	PERMEase
AN401_16655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AN401_16665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AN401_16670	COG0583	DNA-binding transcription factor activity
AN401_16675	COG0408	coproporphyrinogen oxidase activity
AN401_16680	COG0009	L-threonylcarbamoyladenylate synthase
AN401_16685	COG0551	DNA topoisomerase type I activity
AN401_16690	COG2922	Belongs to the Smg family
AN401_16695	COG0758	DNA mediated transformation
AN401_16700	COG1652	LysM domain
AN401_16705	COG0242	peptide deformylase activity
AN401_16710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN401_16715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AN401_16715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN401_16720	COG0569	domain protein
AN401_16725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN401_16730	COG1322	Protein conserved in bacteria
AN401_16750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN401_16755	COG0840	transmembrane signaling receptor activity
AN401_16765	COG2501	S4 domain
AN401_16775	COG2258	MOSC domain
AN401_16785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN401_16800	COG0435	Glutathione S-transferase
AN401_16805	COG1832	CoA-binding protein
AN401_16810	COG1757	Na H antiporter
AN401_16815	COG0174	glutamine synthetase
AN401_16820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN401_16830	COG1012	belongs to the aldehyde dehydrogenase family
AN401_16835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_16845	COG1917	Cupin 2, conserved barrel domain protein
AN401_16845	COG1396	sequence-specific DNA binding
AN401_16850	COG0003	Pfam Anion-transporting ATPase
AN401_16860	COG1966	Carbon starvation protein
AN401_16865	COG5001	Diguanylate cyclase
AN401_16865	COG4251	negative regulation of phosphorylation
AN401_16865	COG3706	GGDEF domain
AN401_16865	COG2203	Gaf domain
AN401_16890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_16895	COG0589	response to stress
AN401_16905	COG4191	Histidine kinase
AN401_16915	COG0584	glycerophosphoryl diester phosphodiesterase
AN401_16925	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AN401_16930	COG3639	organic phosphonate transmembrane transporter activity
AN401_16935	COG3639	organic phosphonate transmembrane transporter activity
AN401_16965	COG0004	ammonium transporteR
AN401_16970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_16970	COG4191	Histidine kinase
AN401_16980	COG1301	dicarboxylic acid transport
AN401_16990	COG2200	EAL domain
AN401_16990	COG2202	Pas domain
AN401_16990	COG2199	diguanylate cyclase activity
AN401_17010	COG0745	RESPONSE REGULATOR receiver
AN401_17025	COG1335	isochorismatase
AN401_17055	COG0583	DNA-binding transcription factor activity
AN401_17075	COG0745	RESPONSE REGULATOR receiver
AN401_17075	COG3706	GGDEF domain
AN401_17085	COG3177	Filamentation induced by cAMP protein fic
AN401_17105	COG1120	ATPase activity
AN401_17110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_17115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_17120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_17190	COG5433	transposase activity
AN401_17200	COG5433	transposase activity
AN401_17205	COG3604	Transcriptional regulator
AN401_17210	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AN401_17220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AN401_17225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_17230	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AN401_17240	COG0640	Transcriptional regulator
AN401_17245	COG0583	DNA-binding transcription factor activity
AN401_17250	COG4771	TonB-dependent receptor
AN401_17255	COG1960	acyl-CoA dehydrogenase activity
AN401_17260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_17265	COG1136	(ABC) transporter
AN401_17265	COG0577	efflux transmembrane transporter activity
AN401_17275	COG0076	glutamate decarboxylase activity
AN401_17280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AN401_17300	COG1120	ATPase activity
AN401_17305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_17310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_17315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_17330	COG2193	ferroxidase activity
AN401_17340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_17345	COG0697	spore germination
AN401_17350	COG1451	nucleotide metabolic process
AN401_17355	COG2223	nitrite transmembrane transporter activity
AN401_17360	COG0515	serine threonine protein kinase
AN401_17365	COG0745	RESPONSE REGULATOR receiver
AN401_17370	COG2205	protein histidine kinase activity
AN401_17375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN401_17380	COG0569	domain protein
AN401_17385	COG0668	transmembrane transport
AN401_17390	COG0625	glutathione transferase activity
AN401_17395	COG0840	transmembrane signaling receptor activity
AN401_17400	COG0583	DNA-binding transcription factor activity
AN401_17410	COG1942	4-Oxalocrotonate Tautomerase
AN401_17415	COG4566	intracellular signal transduction
AN401_17420	COG4191	Histidine kinase
AN401_17425	COG0318	PFAM AMP-dependent synthetase and ligase
AN401_17435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN401_17440	COG1473	amidohydrolase
AN401_17445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_17475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_17490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN401_17495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_17500	COG0419	ATPase involved in DNA repair
AN401_17505	COG0420	3'-5' exonuclease activity
AN401_17515	COG0625	glutathione transferase activity
AN401_17530	COG0210	DNA helicase
AN401_17535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AN401_17540	COG2166	iron-sulfur cluster assembly
AN401_17545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AN401_17550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AN401_17555	COG0583	DNA-binding transcription factor activity
AN401_17560	COG2960	long-chain fatty acid transporting porin activity
AN401_17575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AN401_17580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AN401_17585	COG3118	belongs to the thioredoxin family
AN401_17590	COG0513	Belongs to the DEAD box helicase family
AN401_17595	COG0248	Ppx GppA phosphatase
AN401_17605	COG0084	hydrolase, TatD family'
AN401_17610	COG0805	protein transport
AN401_17615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN401_17625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AN401_17635	COG2226	methyltransferase
AN401_17640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN401_17700	COG0202	RNA polymerase activity
AN401_17705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN401_17710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AN401_17715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN401_17720	COG0201	protein transport
AN401_17725	COG0200	Binds to the 23S rRNA
AN401_17735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AN401_17740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN401_17745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN401_17750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN401_17755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN401_17760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN401_17765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN401_17775	COG0255	Belongs to the universal ribosomal protein uL29 family
AN401_17780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN401_17785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN401_17790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AN401_17795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN401_17805	COG0089	rRNA binding
AN401_17810	COG0088	Forms part of the polypeptide exit tunnel
AN401_17815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN401_17820	COG0051	transcription antitermination factor activity, RNA binding
AN401_17830	COG0137	argininosuccinate synthase activity
AN401_17840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN401_17845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AN401_17855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AN401_17860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AN401_17870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AN401_17875	COG2261	transglycosylase associated protein
AN401_17885	COG2610	gluconate transmembrane transporter activity
AN401_17890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN401_17895	COG1349	DNA-binding transcription factor activity
AN401_17900	COG3622	Belongs to the hyi family
AN401_17905	COG0235	Class ii aldolase
AN401_17910	COG3395	kinase activity
AN401_17915	COG2084	Dehydrogenase
AN401_17920	COG0527	aspartate kinase activity
AN401_17920	COG0460	homoserine dehydrogenase
AN401_17925	COG0626	cystathionine gamma-synthase activity
AN401_17930	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AN401_17935	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN401_17940	COG0494	nUDIX hydrolase
AN401_17950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AN401_17955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AN401_17960	COG1522	sequence-specific DNA binding
AN401_17970	COG0840	transmembrane signaling receptor activity
AN401_17985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN401_17995	COG1012	belongs to the aldehyde dehydrogenase family
AN401_18005	COG0626	cystathionine gamma-synthase activity
AN401_18010	COG0583	DNA-binding transcription factor activity
AN401_18015	COG2183	response to ionizing radiation
AN401_18030	COG2270	Major facilitator Superfamily
AN401_18035	COG0842	Transport permease protein
AN401_18040	COG1131	(ABC) transporter
AN401_18045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_18065	COG3021	interspecies interaction between organisms
AN401_18075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AN401_18085	COG0577	efflux transmembrane transporter activity
AN401_18085	COG1136	(ABC) transporter
AN401_18090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AN401_18095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AN401_18100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AN401_18115	COG3976	FMN-binding domain protein
AN401_18115	COG0431	NADPH-dependent FMN reductase
AN401_18115	COG1053	succinate dehydrogenase
AN401_18140	COG1280	lysine exporter protein (LysE YggA)
AN401_18150	COG1011	Hydrolase
AN401_18155	COG3257	ureidoglycine aminohydrolase activity
AN401_18160	COG0583	DNA-binding transcription factor activity
AN401_18175	COG0765	amino acid transport
AN401_18180	COG0765	amino acid transport
AN401_18195	COG1953	Uracil, thiamine, allantoin
AN401_18210	COG0217	transcriptional regulatory protein
AN401_18225	COG0596	Alpha beta hydrolase
AN401_18230	COG1040	competence protein
AN401_18235	COG0316	Belongs to the HesB IscA family
AN401_18235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AN401_18240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN401_18245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AN401_18250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_18255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AN401_18260	COG4942	peptidase
AN401_18270	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AN401_18285	COG1494	fructose-1,6-bisphosphatase
AN401_18290	COG0288	reversible hydration of carbon dioxide
AN401_18300	COG2177	Part of the ABC transporter FtsEX involved in
AN401_18305	COG2884	Cell division ATP-binding protein ftsE
AN401_18310	COG0552	protein localization to endoplasmic reticulum
AN401_18315	COG0742	ribosomal rna small subunit methyltransferase
AN401_18330	COG2897	thiosulfate sulfurtransferase activity
AN401_18350	COG0733	neurotransmitter:sodium symporter activity
AN401_18360	COG1770	oligopeptidase
AN401_18390	COG3094	Invasion gene expression up-regulator, SirB
AN401_18405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN401_18465	COG5265	(ABC) transporter
AN401_18475	COG0019	diaminopimelate decarboxylase activity
AN401_18490	COG0436	Aminotransferase
AN401_18495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_18525	COG1309	transcriptional regulator
AN401_18530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_18535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_18550	COG0006	proline dipeptidase activity
AN401_18555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN401_18560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AN401_18570	COG0456	acetyltransferase
AN401_18575	COG1490	D-aminoacyl-tRNA deacylase activity
AN401_18580	COG0596	Alpha beta hydrolase
AN401_18585	COG1295	ribonuclease BN
AN401_18595	COG0174	glutamine synthetase
AN401_18605	COG1566	PFAM secretion protein HlyD family protein
AN401_18615	COG3852	Histidine kinase
AN401_18620	COG2204	response regulator
AN401_18635	COG0402	S-adenosylhomocysteine deaminase activity
AN401_18645	COG1609	Transcriptional regulator
AN401_18655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN401_18665	COG3078	GTPase activator activity
AN401_18685	COG1187	pseudouridine synthase activity
AN401_18690	COG0745	RESPONSE REGULATOR receiver
AN401_18695	COG1320	monovalent cation:proton antiporter activity
AN401_18700	COG2212	antiporter activity
AN401_18705	COG1863	multisubunit Na H antiporter MnhE subunit
AN401_18715	COG1006	Multisubunit Na H antiporter MnhC subunit
AN401_18720	COG2111	Na H antiporter
AN401_18730	COG0351	phosphomethylpyrimidine kinase
AN401_18735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN401_18735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN401_18740	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AN401_18745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AN401_18755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AN401_18765	COG0514	ATP-dependent DNA helicase (RecQ)
AN401_18790	COG0210	DNA helicase
AN401_18795	COG1011	Hydrolase
AN401_18800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN401_18810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AN401_18815	COG0019	diaminopimelate decarboxylase activity
AN401_18820	COG1965	Belongs to the frataxin family
AN401_18825	COG3072	Adenylate cyclase
AN401_18830	COG0181	hydroxymethylbilane synthase activity
AN401_18840	COG2959	enzyme of heme biosynthesis
AN401_18845	COG3071	HemY protein
AN401_18850	COG2084	Dehydrogenase
AN401_18870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN401_18875	COG0028	Belongs to the TPP enzyme family
AN401_18885	COG0606	chelatase, subunit chli
AN401_18895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN401_18900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AN401_18940	COG1253	flavin adenine dinucleotide binding
AN401_18945	COG1879	ABC-type sugar transport system periplasmic component
AN401_18955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AN401_18960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN401_18965	COG1349	DNA-binding transcription factor activity
AN401_18970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN401_18975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AN401_18980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN401_18985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN401_18990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN401_18995	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN401_19000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN401_19010	COG0356	it plays a direct role in the translocation of protons across the membrane
AN401_19020	COG1475	DNA binding
AN401_19025	COG1192	Involved in chromosome partitioning
AN401_19030	COG0357	Ribosomal RNA small subunit methyltransferase G
AN401_19035	COG0445	tRNA wobble uridine modification
AN401_19040	COG0716	FMN binding
AN401_19050	COG3267	Type II secretory pathway component ExeA
AN401_19050	COG3409	Peptidoglycan-binding domain 1 protein
AN401_19055	COG2204	response regulator
AN401_19080	COG1450	Type ii and iii secretion system protein
AN401_19095	COG3166	PFAM Fimbrial assembly family protein
AN401_19110	COG2165	general secretion pathway protein
AN401_19120	COG2165	general secretion pathway protein
AN401_19125	COG1459	type II secretion system
AN401_19130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN401_19135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN401_19145	COG0559	Belongs to the binding-protein-dependent transport system permease family
AN401_19155	COG0411	ABC transporter
AN401_19190	COG1139	Iron-sulfur cluster binding protein
AN401_19195	COG0247	lactate metabolic process
AN401_19200	COG1620	l-lactate permease
AN401_19205	COG0583	DNA-binding transcription factor activity
AN401_19210	COG0673	inositol 2-dehydrogenase activity
AN401_19215	COG2855	membrane
AN401_19220	COG0583	DNA-binding transcription factor activity
AN401_19225	COG1309	transcriptional regulator
AN401_19230	COG1902	pentaerythritol trinitrate reductase activity
AN401_19235	COG0840	transmembrane signaling receptor activity
AN401_19240	COG2326	polyphosphate kinase activity
AN401_19245	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AN401_19250	COG1522	sequence-specific DNA binding
AN401_19265	COG1280	lysine exporter protein (LysE YggA)
AN401_19280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AN401_19290	COG0732	type I restriction modification DNA specificity domain
AN401_19295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AN401_19305	COG0464	growth
AN401_19315	COG3550	peptidyl-serine autophosphorylation
AN401_19325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AN401_19330	COG0706	membrane insertase activity
AN401_19335	COG0594	ribonuclease P activity