locus_tag old_locus_tag gene Name start end strand product note type ID NCBI ZOBELLIA_0 ZOBELLIA_0 dnaA dnaA 139 1563 + Chromosomal replication initiator protein%2C DnaA DnaA is a replication initiation factor that plays an important role in the initiation and regulation of chromosomal replication. DnaA promotes the unwinding of DNA at the chromosome origin of replication (oriC)%2C during DNA replication. The formation of the oriC/DnaA complex and DNA unwinding requires ATP hydrolysis. Some 20 DnaA protein molecules bind specifically to double-stranded DNA at a 9 bp consensus (dnaA box) found in the oriC. DnaA is an ATP-and DNA-binding protein. Its N-terminal half binds to the ATP and its C-terminal half could be involved in DNA-binding via an helix-turn-helix domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_0 ZOBELLIA_1 ZOBELLIA_1 ptpA ptpA 1570 2016 + Low molecular weight protein-tyrosine-phosphatase The low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatases) catalyse the removal of a phosphate group attached to a tyrosine residue%2C using a cysteinyl-phosphate enzyme intermediate%3B Belongs to the Tyrosine-specific protein phosphatases family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1 ZOBELLIA_10 ZOBELLIA_10 ZOBELLIA_10 9894 9986 + Putative protein Hypothetical protein gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_10 ZOBELLIA_100 ZOBELLIA_100 ZOBELLIA_100 111146 112948 - Glycoside hydrolase%2C family GH15 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. This enzyme belongs to the family 15 of the glycoside hydrolases. Localized in the cytoplasm.%3B~Specificity unclear gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_100 ZOBELLIA_1000 ZOBELLIA_1000 ZOBELLIA_1000 1193491 1195473 - Conserved hypothetical membrane protein Contains an uncleavable signal peptide%3B localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1000 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1000 ZOBELLIA_1001 ZOBELLIA_1001 mdsA2 mdsA2 1195621 1197276 - Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Specificity unclear gene gene1001 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1001 ZOBELLIA_1002 ZOBELLIA_1002 ZOBELLIA_1002 1197324 1198787 - Sulfatase%2C family S1-15 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 15%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Family membership gene gene1002 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1002 ZOBELLIA_1003 ZOBELLIA_1003 ZOBELLIA_1003 1198777 1199796 - Pseudogene of sulfatase This protein is Could be a pseudogene%3B~Hypothetical protein gene gene1003 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1003 ZOBELLIA_1004 ZOBELLIA_1004 ZOBELLIA_1004 1200004 1201665 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Family membership gene gene1004 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1004 ZOBELLIA_1005 ZOBELLIA_1005 ZOBELLIA_1005 1201677 1204973 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (131-205)%2C and a Plug module (201-311) acting as the channel gate%3B The signal peptide is cleaved between the residue 22 and 23%3B~Family membership gene gene1005 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1005 ZOBELLIA_1006 ZOBELLIA_1006 ZOBELLIA_1006 1205126 1206289 - anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene1006 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1006 ZOBELLIA_1007 ZOBELLIA_1007 ZOBELLIA_1007 1206413 1207012 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene1007 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1007 ZOBELLIA_1008 ZOBELLIA_1008 ZOBELLIA_1008 1207068 1207214 - Putative protein Hypothetical protein gene gene1008 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1008 ZOBELLIA_1009 ZOBELLIA_1009 ZOBELLIA_1009 1207175 1207459 - Putative membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1009 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1009 ZOBELLIA_101 ZOBELLIA_101 otsAB otsAB 113051 115261 + Trehalose-6-phosphate synthase/phosphatase%2C family GT20 This enzyme is involved in the biosynthesis of trehalose. It is a fusion protein between the trehalose-6-phosphate synthase (OtsA) and the trehalose-6-phosphate phosphatase (OtsB). Trehalose-6-phosphate synthase catalyzes the reaction: UDP-glucose + D-glucose 6-phosphate %3D UDP + alpha%2Calpha-trehalose 6-phosphate. It belongs to the family 20 of the glycosyltransferases (GT20). trehalose-6-phosphate phosphatase catalyzes the reaction: trehalose 6-phosphate + H2O %3D trehalose + phosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_101 ZOBELLIA_1010 ZOBELLIA_1010 lamC lamC 1207535 1208983 - Endo-1%2C3-beta-glucanase%2C family GH16 Endo-1%2C3-beta-glucanase (Laminarinase) hydrolyzes the 1%2C3-beta-D-glucosidic linkages in 1%2C3-beta-D-glucans. This laminarinase is a modular protein with a N-terminal catalytic module of the family 16 of glycoside hydrolases (GH16)%2C a central carbohydrate binding module of the family 6 (CBM6) and a C-terminal conserved domain of unknown function. Features a signal peptide cleaved between the residues 22 and 23.%3B~High confidence in function and specificity gene gene1010 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1010 ZOBELLIA_1011 ZOBELLIA_1011 lamE lamE 1209120 1210997 - Endo-1%2C3-beta-glucanase%2C family GH64 Endo-1%2C3-beta-glucanase (Laminarinase) hydrolyzes the 1%2C3-beta-D-glucosidic linkages in 1%2C3-beta-D-glucans. This laminarinase is a modular protein with a N-terminal catalytic module of the family 64 of glycoside hydrolases (GH64)%2C a central carbohydrate binding module of the family 6 (CBM6) and a C-terminal conserved domain of unknown function. Features a signal peptide cleaved between the residues 20 and 21.%3B~Hypothetical protein gene gene1011 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1011 ZOBELLIA_1012 ZOBELLIA_1012 ZOBELLIA_1012 1211316 1214138 - Ligand-binding sensor protein Protein that consists of an N-terminal periplasmic beta-propeller followed by a C-terminal cytoplasmic domain containing a LuxR-type HTH domain acting as transcrptionnal regulator. A transmembrane segment is present between these two domains. Signal peptide cleaved between the residues 25 and 26%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1012 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1012 ZOBELLIA_1013 ZOBELLIA_1013 ZOBELLIA_1013 1214830 1215033 - Transposase (fragment)%2C family 25 Small protein fragment found at the C-terminal extremity of various proteins annotated as transposases and inactivated derivatives that can have until 500 aa. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 25 of transposases%3B Putatively localized in the cytoplasm%3B~High confidence in function and specificity gene gene1013 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1013 ZOBELLIA_1014 ZOBELLIA_1014 lamD lamD 1215548 1218334 - Endo-1%2C3-beta-glucanase%2C family GH16 Endo-1%2C3-beta-glucanase (laminarinase) hydrolyzes the 1%2C3-beta-D-glucosidic linkages in 1%2C3-beta-D-glucans. This laminarinase is a modular protein with a N-terminal catalytic module of the family 16 of glycoside hydrolases (GH16)%2C a central conserved domain of unknown function followed by a carbohydrate binding module of the family 42 (CBM42) and a C-terminal conserved domain of unknown function. Features a signal peptide cleaved between the residues 26 and 27.%3B~High confidence in function and specificity gene gene1014 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1014 ZOBELLIA_1015 ZOBELLIA_1015 ZOBELLIA_1015 1218790 1220373 - Glycoside hydrolase%2C family GH18 Glycoside hydrolase with an unknown substrate specificity. It is a modular enzyme displaying a N-terminal catalytic module belonging to the family 18 of the glycoside hydrolases (GH18) and two C-terminal carbohydrate binding modules belonging to the family 5 of the carbohydrate binding modules that mainly bind to the cellulose and chitin%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Specificity unclear gene gene1015 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1015 ZOBELLIA_1016 ZOBELLIA_1016 ZOBELLIA_1016 1220724 1220987 + Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane.%3B~Hypothetical protein gene gene1016 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1016 ZOBELLIA_1017 ZOBELLIA_1017 porB porB 1221397 1222278 + Beta-porphyranase B%2C family GH16 The beta-porphyranases hydrolyze the 1%2C4-beta-D-galactosidic linkages in porphyrans%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene1017 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1017 ZOBELLIA_1018 ZOBELLIA_1018 ZOBELLIA_1018 1222345 1222611 + Hypothetical protein Protein fragment found in hypothetical transposases%3B Putatively localized in the cytoplasm gene gene1018 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1018 ZOBELLIA_1019 ZOBELLIA_1019 ZOBELLIA_1019 1222665 1223555 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1019 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1019 ZOBELLIA_102 ZOBELLIA_102 ZOBELLIA_102 115550 116725 + Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_102 ZOBELLIA_1020 ZOBELLIA_1020 ZOBELLIA_1020 1223949 1224212 + Putative protein Hypothetical protein gene gene1020 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1020 ZOBELLIA_1021 ZOBELLIA_1021 ZOBELLIA_1021 1224179 1225792 - Glycoside hydrolase%2C family GH16 Glycoside hydrolase belonging to the family GH16. The substrate specificity is unclear. Contains a central carbohydrate binding module of the family 6 (CBM6) and a C-terminal domain of unknown function. Features a uncleaved signal peptide.%3B~Specificity unclear gene gene1021 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1021 ZOBELLIA_1022 ZOBELLIA_1022 ZOBELLIA_1022 1226008 1226739 - Dioxygenase%2C PhyH family Dioxygenase catalyzes the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. The exact specificity of this enzyme is unknown%3B Belongs to the phytanoyl-CoA dioxygenase (PhyH) family%3B Localized in the cytoplasm%3B~Family membership gene gene1022 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1022 ZOBELLIA_1023 ZOBELLIA_1023 ZOBELLIA_1023 1226755 1228776 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1023 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1023 ZOBELLIA_1024 ZOBELLIA_1024 ZOBELLIA_1024 1228802 1230172 - Conserved hypothetical protein Distantly related to the glycoside hydrolases of the families GH37 and GH63 (clan GH-G)%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane gene gene1024 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1024 ZOBELLIA_1025 ZOBELLIA_1025 ZOBELLIA_1025 1230212 1231570 - Sulfatase%2C family S1-20 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Localized in the cytoplasm%3B~Family membership gene gene1025 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1025 ZOBELLIA_1026 ZOBELLIA_1026 nahA1 nahA1 1231605 1233908 - Beta-N-acetylhexosaminidase%2C family GH20 Beta-N-acetylhexosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. Belongs to the family 20 of the glycoside hydrolases. Carbonyl oxygen of the C-2 acetamido group of the substrate acts as the catalytic nucleophile/base in the family GH20. They are involved in different pathways such as the N-Glycan degradation%2C aminosugars metabolism%2C glycosaminoglycan degradation and globoside metabolism. Signal peptide cleaved between the residues 23 and 24. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene1026 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1026 ZOBELLIA_1027 ZOBELLIA_1027 nglA nglA 1233914 1236157 - Alpha-N-acetylglucosaminidase%2C family GH89 Alpha-N-acetylglucosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. It belongs to the family 89 of the glycoside hydrolases. In human%2C this enzyme is involved in the degradation of heparan sulfate. Signal peptide cleaved between the residues 20 and 21. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene1027 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1027 ZOBELLIA_1028 ZOBELLIA_1028 ZOBELLIA_1028 1236191 1236304 - Putative protein Hypothetical protein gene gene1028 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1028 ZOBELLIA_1029 ZOBELLIA_1029 ZOBELLIA_1029 1236314 1237885 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane%3B~Family membership gene gene1029 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1029 ZOBELLIA_103 ZOBELLIA_103 ZOBELLIA_103 116830 118188 + DEAD/DEAH RNA helicase Protein that could be involved in ATP-dependent RNA unwinding in a variety of cellular processes%2C including ribosome assembly%2C protein synthesis%2C and RNA degradation%3B Contains a DEAD box%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%2C DEAD box subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_103 ZOBELLIA_1030 ZOBELLIA_1030 ZOBELLIA_1030 1237906 1241163 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (35-108) and the Plug module (125-253) acting as a channel gate%3B The signal peptide is cleaved between the residues 27 and 28%3B~Family membership gene gene1030 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1030 ZOBELLIA_1031 ZOBELLIA_1031 ZOBELLIA_1031 1241559 1245806 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1031 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1031 ZOBELLIA_1032 ZOBELLIA_1032 ZOBELLIA_1032 1245973 1246194 + Putative protein Hypothetical protein gene gene1032 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1032 ZOBELLIA_1033 ZOBELLIA_1033 ZOBELLIA_1033 1246243 1246335 + Putative protein Hypothetical protein gene gene1033 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1033 ZOBELLIA_1034 ZOBELLIA_1034 ZOBELLIA_1034 1246369 1246467 - Putative protein Hypothetical protein gene gene1034 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1034 ZOBELLIA_1035 ZOBELLIA_1035 ZOBELLIA_1035 1246847 1247059 - Conserved hypothetical protein Putatively localized in the cytoplasm. gene gene1035 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1035 ZOBELLIA_1036 ZOBELLIA_1036 ZOBELLIA_1036 1247366 1248433 - 6-phosphogluconolactonase-like protein Conserved protein distantly related to 6-phosphogluconolactonases%3B Localized in the cytoplasm%3B~Function unclear gene gene1036 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1036 ZOBELLIA_1037 ZOBELLIA_1037 ZOBELLIA_1037 1248568 1249296 - Creatinase family protein Conserved protein belonging to the creatinase family%2C but its exact function is unclear%3B Localized in the cytoplasm%3B~Family membership gene gene1037 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1037 ZOBELLIA_1038 ZOBELLIA_1038 ZOBELLIA_1038 1249307 1250290 - Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B localized in the cytoplasm%3B~Family membership gene gene1038 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1038 ZOBELLIA_1039 ZOBELLIA_1039 ZOBELLIA_1039 1250293 1251078 - Dioxygenase%2C PhyH family Dioxygenase catalyzes the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. The exact specificity of this enzyme is unknown%3B Belongs to the phytanoyl-CoA dioxygenase (PhyH) family%3B Localized in the cytoplasm%3B~Family membership gene gene1039 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1039 ZOBELLIA_104 ZOBELLIA_104 ZOBELLIA_104 118313 119926 + Aminopeptidase%2C family M1 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. This enzyme belongs to the family M1 of the peptidases. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm.%3B~Specificity unclear gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_104 ZOBELLIA_1040 ZOBELLIA_1040 ZOBELLIA_1040 1251098 1253581 - Sodium/solute symporter Modular protein containing a N-terminal 7-bladed beta propeller domain (Galactose oxidase central domain family) and a C-terminal Sodium-solute symporter. Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains thirteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1040 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1040 ZOBELLIA_1041 ZOBELLIA_1041 nanA1 nanA1 1253770 1254666 - N-acetylneuraminate lyase N-acetylneuraminate lyase is involved in sialic acid metabolism. It catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. NanA belongs to the dihidropicolinate synthase (DHDPS) family and forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1041 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1041 ZOBELLIA_1042 ZOBELLIA_1042 nanH nanH 1254752 1255912 - Sialidase%2C family GH33 Sialidase catalyzes the hydrolysis of alpha-(2->3)-%2C alpha-(2->6)-%2C alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides%2C glycoproteins%2C glycolipids%2C colominic acid and synthetic substrates. It belongs to the family 33 of the glycoside hydrolases. Features a signal peptide cleaved between residues 26 and 27. Localized in the periplasm.%3B~High confidence in function and specificity gene gene1042 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1042 ZOBELLIA_1043 ZOBELLIA_1043 nanA2 nanA2 1255974 1256912 - N-acetylneuraminate lyase N-acetylneuraminate lyase is involved in sialic acid metabolism. It catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. NanA belongs to the dihidropicolinate synthase (DHDPS) family and forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1043 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1043 ZOBELLIA_1044 ZOBELLIA_1044 ZOBELLIA_1044 1257128 1258348 - N-acetyl-D-glucosamine 2-epimerase N-acetyl-D-glucosamine 2-epimerase catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. It functions as a homodimer%2C where monomer has an alpha(6)/alpha(6)-barrel structure commonly found in glucoamylases and cellulases This enzyme is involved in sialic acid metabolism. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1044 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1044 ZOBELLIA_1045 ZOBELLIA_1045 ZOBELLIA_1045 1258422 1259564 - Conserved hypothetical protein Localized in the cytoplasm gene gene1045 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1045 ZOBELLIA_1046 ZOBELLIA_1046 paaF paaF 1259564 1260340 - Enoyl-CoA hydratase The enoyl-CoA hydratase (ECH) is an enzyme involved in fatty acid metabolism. It catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA.%3B~High confidence in function and specificity gene gene1046 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1046 ZOBELLIA_1047 ZOBELLIA_1047 frcA frcA 1260354 1261559 - Formyl-coenzyme A transferase Formyl-coenzyme A transferase catalyzes the first step of the oxalic acid catabolism. It transfers the CoA moiety from formyl-CoA to oxalate . FcrA belongs to the CoA-transferase family III and forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1047 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1047 ZOBELLIA_1048 ZOBELLIA_1048 fabG3 fabG3 1261622 1262392 - 3-Oxoacyl-[acyl-carrier-protein] reductase Involved in first reduction step of the fatty acid biosynthesis pathway. Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily. Contains a signal peptide cleaved between the residues 27 and 28. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene1048 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1048 ZOBELLIA_1049 ZOBELLIA_1049 nanA3 nanA3 1262513 1263409 - N-acetylneuraminate lyase N-acetylneuraminate lyase is involved in sialic acid metabolism. It catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. NanA belongs to the dihidropicolinate synthase (DHDPS) family and forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1049 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1049 ZOBELLIA_105 ZOBELLIA_105 ZOBELLIA_105 120004 123039 - Conserved hypothetical lipoprotein Protein that contains a N-terminal domain of about 740 residues whithout any similarity then%2C in the C-terminal part a PKD domain and a C-type cytochrome domain are present%3B Lipoprotein with a signal peptide cleaved between the residues 18 and 19%2C Localized in the cytoplasmic or outer membrane (or both)%3B~Conserved hypothetical protein gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_105 ZOBELLIA_1050 ZOBELLIA_1050 ZOBELLIA_1050 1263490 1263594 - Putative protein Hypothetical protein gene gene1050 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1050 ZOBELLIA_1051 ZOBELLIA_1051 ZOBELLIA_1051 1263644 1265077 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Probably localized in the outer membrane%3B~Family membership gene gene1051 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1051 ZOBELLIA_1052 ZOBELLIA_1052 ZOBELLIA_1052 1265104 1268442 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (31-104) and the Plug module (120-237) acting as a channel gate%3B The signal peptide is cleaved between the residues 27 and 28%3B~Family membership gene gene1052 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1052 ZOBELLIA_1053 ZOBELLIA_1053 ZOBELLIA_1053 1268606 1269304 + GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B Contains an N-terminal HTH domain of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA and a C-terminal FCD domain that probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N- terminal DNA-binding domain (HTH domain)%3B Localized in the cytoplasm%3B~Family membership gene gene1053 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1053 ZOBELLIA_1054 ZOBELLIA_1054 sgsA1 sgsA1 1269790 1271394 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Putative lipoprotein with a signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene1054 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1054 ZOBELLIA_1055 ZOBELLIA_1055 ZOBELLIA_1055 1271452 1273287 - (Trans)glycosidase superfamily protein This conserved protein belongs to the (Trans)glycosidase superfamily%2C which is included in the TIM beta/alpha-barrel fold. This protein is distantly related to the glycoside hydrolases from the family GH36%3B Localized in the cytoplasm%3B~Family membership gene gene1055 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1055 ZOBELLIA_1056 ZOBELLIA_1056 ZOBELLIA_1056 1273514 1275004 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 21 and 22%3B Putatively localized in the outer membrane%3B~Family membership gene gene1056 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1056 ZOBELLIA_1057 ZOBELLIA_1057 ZOBELLIA_1057 1275034 1278369 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (49-100)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (122-196)%2C and a Plug module (212-338) acting as the channel gate%3B The signal peptide is cleaved between the residue 22 and 23%3B~Family membership gene gene1057 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1057 ZOBELLIA_1058 ZOBELLIA_1058 ZOBELLIA_1058 1278595 1279728 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene1058 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1058 ZOBELLIA_1059 ZOBELLIA_1059 ZOBELLIA_1059 1279893 1280471 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene1059 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1059 ZOBELLIA_106 ZOBELLIA_106 ZOBELLIA_106 123219 123812 + SAM-dependent methyltransferase Methyltransferase using S-adenosylmethionine as cofactor. Its exact function is unknown. Localized in the cytoplasm.%3B~Function unclear gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_106 ZOBELLIA_1060 ZOBELLIA_1060 ZOBELLIA_1060 1280496 1280765 + Pseudogene N-terminal fragment of conserved protein found in the PhnB family protein%3B Possibly localized in the cytoplasm%3B~Conserved hypothetical protein pseudogene gene1060 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1060 ZOBELLIA_1061 ZOBELLIA_1061 ZOBELLIA_1061 1280797 1280919 + Pseudogene C-terminal fragment of conserved protein found in the PhnB family protein%3B Possibly localized in the cytoplasm%3B~Conserved hypothetical protein pseudogene gene1061 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1061 ZOBELLIA_1062 ZOBELLIA_1062 ZOBELLIA_1062 1281162 1281653 + Thiol-disulfide oxidoreductase Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Belongs to the thioredoxin family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1062 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1062 ZOBELLIA_1063 ZOBELLIA_1063 ZOBELLIA_1063 1281656 1282354 + Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Features a signal peptide cleaved between the residues 25 and 26. Localized in the periplasm.%3B~Family membership gene gene1063 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1063 ZOBELLIA_1064 ZOBELLIA_1064 ZOBELLIA_1064 1282615 1283190 + Conserved hypothetical protein Localized in the cytoplasm gene gene1064 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1064 ZOBELLIA_1065 ZOBELLIA_1065 cspA1 cspA1 1283254 1283445 - Cold shock protein Cold shock proteins (CSPs) help the cell to survive in temperatures lower than optimum growth temperature. CSPs may act as RNA chaperones by destabilizing RNA secondary structures%2C regulating ribosomal translation%2C rate of mRNA degradation and termination of transcription%3B Contains a 'cold-shock domain' (CSD) involved in the single-strand nucleic-acid binding%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1065 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1065 ZOBELLIA_1066 ZOBELLIA_1066 ZOBELLIA_1066 1283472 1284629 - DEAD/DEAH RNA helicase Protein that could be involved in ATP-dependent RNA unwinding in a variety of cellular processes%2C including ribosome assembly%2C protein synthesis%2C and RNA degradation%3B Contains a DEAD box%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%2C DEAD box subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1066 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1066 ZOBELLIA_1067 ZOBELLIA_1067 des6-2 des6-2 1284639 1285640 - Linoleoyl-CoA desaturase Linoleoyl-CoA desaturase%2C also known as delta 6-desaturase%2C is responsible for the conversion of linoleic acid (18:2) to gamma-linolenic acid (18:3 gamma). It uses iron ion as a cofactor. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1067 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1067 ZOBELLIA_1068 ZOBELLIA_1068 ZOBELLIA_1068 1285990 1286247 + Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1068 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1068 ZOBELLIA_1069 ZOBELLIA_1069 ZOBELLIA_1069 1286459 1286941 + Hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1069 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1069 ZOBELLIA_107 ZOBELLIA_107 ZOBELLIA_107 123828 124205 - Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_107 ZOBELLIA_1070 ZOBELLIA_1070 ZOBELLIA_1070 1287191 1288165 + Serine peptidase%2C family S12 Serine peptidase belonging to the family S12%2C which includes D-Ala-D-Ala carboxypeptidase B and aminopeptidase DmpB. The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa- Thr-Lys. Localized in the cytoplasm.%3B~Specificity unclear gene gene1070 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1070 ZOBELLIA_1071 ZOBELLIA_1071 ZOBELLIA_1071 1288370 1289275 + Ribonuclease BN family protein Conserved protein distantly related to the ribonuclease BN%2C a 3' to 5' exoribonuclease necessary for 3' maturation of tRNA molecules%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1071 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1071 ZOBELLIA_1072 ZOBELLIA_1072 ZOBELLIA_1072 1289390 1290133 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene1072 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1072 ZOBELLIA_1073 ZOBELLIA_1073 ZOBELLIA_1073 1290183 1290422 + Conserved hypothetical protein Localized in the cytoplasm. gene gene1073 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1073 ZOBELLIA_1074 ZOBELLIA_1074 ZOBELLIA_1074 1290460 1291485 + Conserved hypothetical membrane protein Conserved hypothetical protein belonging to the DUF20 family proteins. This family is predicted to be composed of permeases%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1074 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1074 ZOBELLIA_1075 ZOBELLIA_1075 ZOBELLIA_1075 1291692 1291991 + Possible Sigma-54 modulation protein Probably modulates the activity of sigma-54 factor%3B Belongs to the sigma-54 modulation protein/ribosomal protein S30EA family%3B Localized in the cytoplasm%3B~Function unclear gene gene1075 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1075 ZOBELLIA_1076 ZOBELLIA_1076 ZOBELLIA_1076 1292030 1292191 + Putative protein Hypothetical protein gene gene1076 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1076 ZOBELLIA_1077 ZOBELLIA_1077 ZOBELLIA_1077 1292255 1294063 + Citrate transporter family protein The exact specificity of this conserved ion transporter is unknown%3B belongs to the citrate transporter family%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1077 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1077 ZOBELLIA_1078 ZOBELLIA_1078 ZOBELLIA_1078 1294075 1294974 + Small-conductance mechanosensitive channel Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains three transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1078 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1078 ZOBELLIA_1079 ZOBELLIA_1079 ZOBELLIA_1079 1295050 1296150 + Conserved hypothetical membrane protein The DUF20 family proteins are predicted to be permeases%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1079 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1079 ZOBELLIA_108 ZOBELLIA_108 ZOBELLIA_108 124545 125348 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_108 ZOBELLIA_1080 ZOBELLIA_1080 ZOBELLIA_1080 1296197 1296382 - Putative membrane protein Contains a C-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1080 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1080 ZOBELLIA_1081 ZOBELLIA_1081 ZOBELLIA_1081 1296427 1296573 + Putative membrane protein Contains a transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1081 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1081 ZOBELLIA_1082 ZOBELLIA_1082 topA2 topA2 1296613 1297683 + DNA topoisomerase 1B DNA topoisomerase 1B relaxes supercoiled DNA. Modifies DNA topology by introducing ATP-independent reversible enzyme-linked breaks in the DNA phosphodiester backbone. This is accomplished by cleaving one strand of the DNA duplex and passing the intact complementary strand through the nick. Cleaves DNA after CCCTT sequence. This enzyme is closely related to the DNA topoisomerase 1B from Mimivirus%3B Belongs to the eukaryotic type I topoisomerase family%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1082 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1082 ZOBELLIA_1083 ZOBELLIA_1083 ZOBELLIA_1083 1297882 1298331 + Conserved hypothetical protein Localized in the cytoplasm gene gene1083 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1083 ZOBELLIA_1084 ZOBELLIA_1084 ZOBELLIA_1084 1298334 1299149 + Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF159 family%3B Localized in the cytoplasm gene gene1084 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1084 ZOBELLIA_1085 ZOBELLIA_1085 ZOBELLIA_1085 1299314 1299475 + Putative membrane protein Contains a signal peptide cleaved between the residues 27 and 28 followed by a transmembrane segment%3B Possibly localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1085 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1085 ZOBELLIA_1086 ZOBELLIA_1086 ZOBELLIA_1086 1299504 1299695 + Conserved hypothetical protein Putative lipoprotein signal peptide cleaved between the residues 22 and 23%3B Possibly localized in the outer membrane gene gene1086 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1086 ZOBELLIA_1087 ZOBELLIA_1087 ZOBELLIA_1087 1299966 1300529 + Two-component system-Response regulator%2C effector domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the effector domain only%2C an AraC-type HTH domain%3B~Family membership gene gene1087 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1087 ZOBELLIA_1088 ZOBELLIA_1088 ZOBELLIA_1088 1300539 1300985 + Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene1088 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1088 ZOBELLIA_1089 ZOBELLIA_1089 ZOBELLIA_1089 1300991 1303990 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments and two N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1089 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1089 ZOBELLIA_109 ZOBELLIA_109 ccpA1 ccpA1 125410 126456 + Di-heme cytochrome c peroxidase Di-heme cytochrome c peroxidase (CCP) reduces hydrogen peroxide to water using c-type heme as an oxidizable substrate. However%2C since it possesses two%2C instead of one%2C heme prosthetic groups%2C CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two heme groups have significantly different redox potentials. CCP is structured into two domains%2C each containing one c-type haem group%2C with a calcium-binding site at the domain interface. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_109 ZOBELLIA_1090 ZOBELLIA_1090 ZOBELLIA_1090 1304290 1304433 + Putative protein Hypothetical protein gene gene1090 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1090 ZOBELLIA_1091 ZOBELLIA_1091 ZOBELLIA_1091 1304399 1305427 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1091 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1091 ZOBELLIA_1092 ZOBELLIA_1092 ZOBELLIA_1092 1305693 1306184 - Conserved hypothetical protein Highly conserved protein Belongs to the DUF892 family%3B Localized in the cytoplasm%3B~Function unclear gene gene1092 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1092 ZOBELLIA_1093 ZOBELLIA_1093 ZOBELLIA_1093 1306181 1306375 - Putative membrane protein Contains a transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1093 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1093 ZOBELLIA_1094 ZOBELLIA_1094 dpsA2 dpsA2 1306401 1306901 + DNA protection during starvation protein DspA protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions%2C which prevents hydroxyl radical production by the Fenton reaction%3B Forms a homododecamer and the 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1094 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1094 ZOBELLIA_1095 ZOBELLIA_1095 ZOBELLIA_1095 1306970 1307407 - Expression activator-related protein Protein%2C involved in sensory transduction in microorganisms%2C and that consists of an N-terminal BLUF (sensors of blue-light using FAD) domain. This domain is involved in sensing blue-light (and possibly redox) using FAD and is Localized in the cytoplasm%3B~Function unclear gene gene1095 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1095 ZOBELLIA_1096 ZOBELLIA_1096 ZOBELLIA_1096 1307523 1307648 + Putative protein Hypothetical protein gene gene1096 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1096 ZOBELLIA_1097 ZOBELLIA_1097 ZOBELLIA_1097 1307620 1309941 - Bacterial surface antigen Protein belonging to the bacterial surface antigen family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Function unclear gene gene1097 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1097 ZOBELLIA_1098 ZOBELLIA_1098 ZOBELLIA_1098 1309944 1314890 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1098 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1098 ZOBELLIA_1099 ZOBELLIA_1099 ZOBELLIA_1099 1315052 1315807 - Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene1099 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1099 ZOBELLIA_11 ZOBELLIA_11 ZOBELLIA_11 10047 10673 + Conserved hypothetical membrane protein Contains one C-terminal transmembrane segment%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_11 ZOBELLIA_110 ZOBELLIA_110 ZOBELLIA_110 126431 127450 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_110 ZOBELLIA_1100 ZOBELLIA_1100 ZOBELLIA_1100 1315808 1316251 - Putative protein Hypothetical protein gene gene1100 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1100 ZOBELLIA_1101 ZOBELLIA_1101 ZOBELLIA_1101 1316421 1316930 - Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~Specificity unclear gene gene1101 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1101 ZOBELLIA_1102 ZOBELLIA_1102 gdhA gdhA 1317185 1318003 + Glucose 1-dehydrogenase Glucose dehydrogenase catalyses the oxidation of D-glucose without prior phosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme%3B Belongs to the short-chain dehydrogenases/reductases family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1102 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1102 ZOBELLIA_1103 ZOBELLIA_1103 ZOBELLIA_1103 1318130 1318948 + Short-chain dehydrogenase/reductase SDR Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene1103 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1103 ZOBELLIA_1104 ZOBELLIA_1104 ZOBELLIA_1104 1318997 1319485 + Hypothetical protein Putative transcriptional regulator%3B Localized in the cytoplasm gene gene1104 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1104 ZOBELLIA_1105 ZOBELLIA_1105 ZOBELLIA_1105 1319482 1319613 + Conserved hypothetical protein Localized in the cytoplasm gene gene1105 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1105 ZOBELLIA_1106 ZOBELLIA_1106 ZOBELLIA_1106 1320348 1321703 + Exopolysaccharide production protein Conserved protein involved in exopolysaccharide biosynthesis. Its exact function is unknown. Contains five transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene1106 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1106 ZOBELLIA_1107 ZOBELLIA_1107 ZOBELLIA_1107 1321753 1322016 + Putative protein Hypothetical protein gene gene1107 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1107 ZOBELLIA_1108 ZOBELLIA_1108 etkA etkA 1322028 1324304 + Tyrosine-protein kinase May be involved in the production and the transport of exopolysaccharides%3B Contains a N-terminal transmembrane segment%3B Belongs to the etk/wzc family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1108 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1108 ZOBELLIA_1109 ZOBELLIA_1109 ZOBELLIA_1109 1324304 1325662 + O-antigen transporter May be involved in the Lipopolysaccharide O antigen biosynthesis%2C translocating the nascent polysaccharidic O-antigen molecules and/or ligating them to lipid A core units%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1109 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1109 ZOBELLIA_111 ZOBELLIA_111 30288 30288 127665 128360 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_111 ZOBELLIA_1110 ZOBELLIA_1110 ZOBELLIA_1110 1325659 1326984 + Conserved hypothetical membrane protein Contains ten transmenbrane segments%3B Localized ion the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1110 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1110 ZOBELLIA_1111 ZOBELLIA_1111 ZOBELLIA_1111 1327071 1328003 + O-acetyltransferase Probably required for the acetyl modification of sugars of the oligosaccharides during the exopolysaccharide biosynthesis%3B Contains ten transmenbrane segments%3B Belongs to the acyltransferase 3 family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1111 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1111 ZOBELLIA_1112 ZOBELLIA_1112 ZOBELLIA_1112 1328092 1329243 + Acetyltransferase Probably required for the acetyl modification of sugars of the oligosaccharides during the exopolysaccharide biosynthesis%3B Contains ten transmenbrane segments%3B Belongs to the acyltransferase 3 family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1112 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1112 ZOBELLIA_1113 ZOBELLIA_1113 ZOBELLIA_1113 1329319 1330473 + Mannosyltransferase%2C family GT4 Mannosyltransferase catalyses the transfer of mannose from GDP-mannose to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Likely involved in the biosynthesis of O-antigen. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1113 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1113 ZOBELLIA_1114 ZOBELLIA_1114 ZOBELLIA_1114 1330547 1331806 + Glycosyltransferase%2C family GT4 Glycosyltransferase that could be involved in the exopolysaccharide or lipopolysaccharide biosynthesis%3B Belongs to the family 4 of glycosyltransferase (GT4)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1114 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1114 ZOBELLIA_1115 ZOBELLIA_1115 ZOBELLIA_1115 1331998 1333326 + Coenzyme A ligase Protein putatively involved in the exopolysaccharide biosynthesis%3B Localized in the cytoplasm%3B~Function unclear gene gene1115 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1115 ZOBELLIA_1116 ZOBELLIA_1116 ZOBELLIA_1116 1333335 1334396 + Conserved hypothetical protein Localized in the cytoplasm gene gene1116 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1116 ZOBELLIA_1117 ZOBELLIA_1117 ZOBELLIA_1117 1334415 1335317 - Glycosyltransferase%2C family 2 Putatively involved in the Lipopolysaccharide core biosynthesis%3B Belongs to the family 2 of glycosyl transferase (GT2)%2C WaaE/kdtX subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1117 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1117 ZOBELLIA_1118 ZOBELLIA_1118 wcaF wcaF 1335317 1335862 - Colanic acid biosynthesis acetyltransferase Protein involved in the biosynthetis of colanic acid%2C an exopolysaccharide. This protein belongs to the o-acetyltransferase family. Its features three tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which has been shown to fold as a left-handed parallel beta helix. Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1118 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1118 ZOBELLIA_1119 ZOBELLIA_1119 ZOBELLIA_1119 1335855 1336997 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 4 of the glycosyltransferases (GT4)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1119 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1119 ZOBELLIA_112 ZOBELLIA_112 ZOBELLIA_112 128400 129620 + Serine peptidase%2C family S9 Protein containing a N-terminal serine peptidase of the family S9 and and a C-terminal OsmC domain involved in the osmotic stress. The active site residues of family S9 serine peptidases are in the order Ser%2C Asp%2C His in the sequence. Localized in the cytoplasm.%3B~Specificity unclear gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_112 ZOBELLIA_1120 ZOBELLIA_1120 ZOBELLIA_1120 1337026 1338006 - Mannosyltransferase%2C family GT4 Mannosyltransferase catalyses the transfer of mannose from GDP-mannose to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Likely involved in the biosynthesis of O-antigen. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1120 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1120 ZOBELLIA_1121 ZOBELLIA_1121 ZOBELLIA_1121 1338352 1340541 - Beta-helix fold protein Hypothetical protein predicted to adopts a right handed parallel beta-helix fold%3B Contains a signal peptide cleaved between the residues 17 and 18%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1121 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1121 ZOBELLIA_1122 ZOBELLIA_1122 ZOBELLIA_1122 1340538 1341281 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1122 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1122 ZOBELLIA_1123 ZOBELLIA_1123 ZOBELLIA_1123 1341286 1342491 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1123 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1123 ZOBELLIA_1124 ZOBELLIA_1124 ZOBELLIA_1124 1342773 1343276 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1124 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1124 ZOBELLIA_1125 ZOBELLIA_1125 mutA mutA 1343494 1344879 + Methylmalonyl-CoA mutase small subunit Methylmalonyl-CoA mutase is a heterodimer of a small (alpha) and a large (beta) chain. These two subunits are non-identical%2C yet structurally related chains. MutA codes the small subunit. Methylmalonyl-CoA mutase is an adenosylcobalamin (vitamin B12) dependent enzyme that catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1125 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1125 ZOBELLIA_1126 ZOBELLIA_1126 mutB mutB 1344892 1346982 + Methylmalonyl-CoA mutase large subunit Methylmalonyl-CoA mutase is a heterodimer of a small (alpha) and a large (beta) chain. These two subunits are non-identical%2C yet structurally related chains. MutB codes the large subunit. Methylmalonyl-CoA mutase is an adenosylcobalamin (vitamin B12) dependent enzyme that catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1126 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1126 ZOBELLIA_1127 ZOBELLIA_1127 ZOBELLIA_1127 1347246 1348811 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain. Features also in the N-terminal region a transmembrane helix%2C a domain of unknown function followed by another transmembrane helix. The histine kinase domain is the C-terminal region. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene1127 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1127 ZOBELLIA_1128 ZOBELLIA_1128 ZOBELLIA_1128 1348816 1349211 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C which acts as transcriptional regulator. Localized in the cytoplasm.%3B~Specificity unclear gene gene1128 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1128 ZOBELLIA_113 ZOBELLIA_113 ZOBELLIA_113 129752 130390 + Conserved hypothetical membrane protein Protein containing a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_113 ZOBELLIA_1130 ZOBELLIA_1130 ZOBELLIA_1130 1349472 1349924 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1130 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1130 ZOBELLIA_1131 ZOBELLIA_1131 ZOBELLIA_1131 1349940 1351373 - Conserved hypothetical membrane protein Contains five transmembrane helices in the N-terminal region and a central motif reminiscent of the Planctomycetes cytochrome C motif%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1131 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1131 ZOBELLIA_1132 ZOBELLIA_1132 ZOBELLIA_1132 1351377 1352837 - Conserved hypothetical protein. Conserved hypothetical protein belonging to the DUF1501 family%2C in the alkaline-phosphatase clan%3B Contains a twin-arginine signal peptide%3B Localized in the periplasmic space gene gene1132 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1132 ZOBELLIA_1133 ZOBELLIA_1133 ZOBELLIA_1133 1352841 1355174 - Conserved cytochrome c-containing protein Modular protein with a N-terminal cytochrome C Planctomycetes specific%2C and two domains of unknown function (DUF1549 and DUF1553) always associated with the Planctomycete cytochrome C domain. Cytochromes C typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B This protein could result of a lateral transfer from a Planctomycetes%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1133 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1133 ZOBELLIA_1134 ZOBELLIA_1134 ZOBELLIA_1134 1355266 1355364 - Putative protein Hypothetical protein gene gene1134 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1134 ZOBELLIA_1135 ZOBELLIA_1135 cpsA1 cpsA1 1355372 1356559 - Carboxypeptidase%2C family M20 Carboxypeptidase catalyzes the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides. This enzyme can release basic%2C acidic%2C aromatic%2C and%2C to a lesser extent%2C aliphatic amino acids. Belongs to the family M20 of the metallopeptidase. CpsA binds two co-catalytic zinc ions%2C which are coordinated by five conserved residues (His/Asp%2C Asp%2C Glu%2C Glu/Asp%2C His). The zinc ions stabilize the tetrahedral intermediate and activate the catalytic water molecule. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1135 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1135 ZOBELLIA_1136 ZOBELLIA_1136 ZOBELLIA_1136 1356596 1357138 - YceI family protein Protein Belongs to the YceI (UPF0312) family%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Family membership gene gene1136 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1136 ZOBELLIA_1137 ZOBELLIA_1137 ZOBELLIA_1137 1357200 1358246 - Conserved hypothetical membrane protein Lipoprotein that contains a domain found in some eukaryotic and prokaryotic protein kinase and in eukaryotic proteins required for post-translational sulfatase modification%3B Putative signal peptide cleaved between the residues 21 and 22%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1137 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1137 ZOBELLIA_1138 ZOBELLIA_1138 ZOBELLIA_1138 1358453 1359145 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1138 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1138 ZOBELLIA_1139 ZOBELLIA_1139 ZOBELLIA_1139 1359148 1359282 - Conserved hypothetical protein Localized in the cytoplasm. gene gene1139 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1139 ZOBELLIA_114 ZOBELLIA_114 sodC sodC 130593 131198 + Superoxide dismutase [Cu-Zn] Superoxide dismutase destroys radicals which are normally produced by the cells and which are toxic to biological systems. It catalyzes the dismutation of superoxide into molecular oxygen and hydrogen peroxide. It forms a homodimer and binds one iron and one copper ion as cofactors per subunit%3B Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_114 ZOBELLIA_1140 ZOBELLIA_1140 ZOBELLIA_1140 1359341 1360360 - NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase that adopts a Rossmann fold%3B belongs to the GFO/IDH/MOCA family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1140 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1140 ZOBELLIA_1141 ZOBELLIA_1141 ZOBELLIA_1141 1360430 1361794 - Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Family membership gene gene1141 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1141 ZOBELLIA_1142 ZOBELLIA_1142 ZOBELLIA_1142 1361791 1365102 - Multidrug efflux transporter Integral membrane protein involved in drug resistance that belongs to the acrB/acrD/acrF family%3B Contains 12 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2%2C and helices 7 and 8. The three transmembrane domains form a large%2C 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1142 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1142 ZOBELLIA_1143 ZOBELLIA_1143 ZOBELLIA_1143 1365102 1366238 - Membrane fusion protein The membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmic membrane by a N-terminal transmembrane region%3B participates to the type I secretion system%3B~Family membership gene gene1143 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1143 ZOBELLIA_1144 ZOBELLIA_1144 ZOBELLIA_1144 1366413 1367285 - Receptor-like protein kinase Protein receptor with a serine/threonine-protein kinase activity and containing seven leucine-rich repeats that generally folds into an arc or horseshoe shape%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Specificity unclear gene gene1144 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1144 ZOBELLIA_1145 ZOBELLIA_1145 ZOBELLIA_1145 1367460 1369370 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Contains a duplicated ATPase domain%3B Belongs to the ABC transporter family%2C EF3 subfamily%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with a membrane permease component%3B~Family membership gene gene1145 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1145 ZOBELLIA_1146 ZOBELLIA_1146 ZOBELLIA_1146 1369508 1369924 + Conserved hypothetical membrane protein Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1146 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1146 ZOBELLIA_1147 ZOBELLIA_1147 ZOBELLIA_1147 1369902 1370954 - FAD dependent oxidoreductase Protein that consists of a FAD dependent oxidoreductase domain%3B belongs to the D-amino acid oxidases (DAO) family%3B Localized in the cytoplasm%3B~Family membership gene gene1147 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1147 ZOBELLIA_1148 ZOBELLIA_1148 gldN gldN 1371046 1371948 - Gliding motility protein Protein putatively involved in the gliding motility%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Function unclear gene gene1148 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1148 ZOBELLIA_1149 ZOBELLIA_1149 gldM gldM 1372008 1373567 - Gliding motility protein Protein involved in the gliding motility%3B Contains a N-terminal transmembrane segment%3B Anchored in the cytoplasmic membrane and exposed in the periplasmic space%3B~Function unclear gene gene1149 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1149 ZOBELLIA_115 ZOBELLIA_115 ZOBELLIA_115 131282 132382 - Bacterial surface antigen Conserved protein belonging to the bacterial surface antigen family%2C which includes D15 antigen from H. influenzae%2C OMA87 from P.multocida%2C OMP85 from N. meningitidis and N.gonorrhoeae. Features a signal peptide cleaved between the residues 22 and 23. Predicted to be Localized in the outer membrane.%3B~Function unclear gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_115 ZOBELLIA_1150 ZOBELLIA_1150 gldL gldL 1373624 1374280 - Gliding motility membrane protein Membrane protein involved in the gliding motility%3B The GldL protein interacts with the GldK protein to inhibit the motility. GldL alone does not inhibit the motility%3B Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1150 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1150 ZOBELLIA_1151 ZOBELLIA_1151 gldK gldK 1374420 1375775 - Gliding motility membrane lipoprotein Lipoprotein involved in the gliding motility that contains an unknown function domain found in some eukaryotic and prokaryotic protein and in eukaryotic proteins required for post-translational modification of sulfatase%3B Signal peptide cleaved between the residues 17 and 18%3B Putatively localized in the outer membrane%3B~Function unclear gene gene1151 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1151 ZOBELLIA_1152 ZOBELLIA_1152 ZOBELLIA_1152 1375899 1377056 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene1152 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1152 ZOBELLIA_1153 ZOBELLIA_1153 topA1 topA1 1377169 1379661 - DNA topoisomerase IA The DNA topoisomerase I is responsible primarily for the relaxation of negative supercoils. It has also been involved in knotting and unknotting DNA and in linking complementary rings of single-stranded DNA into double-stranded rings%3B The type I topoisomerases catalyze the interconversion of DNA topoisomers by transient ATP-independent breakage of single-stranded DNA and the subsequent rejoining of the strands via a protein-DNA link where the hydroxyl group of a tyrosine residue is joined to a 5'-phosphate on DNA%3B Belongs to the prokaryotic type I topoisomerase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1153 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1153 ZOBELLIA_1154 ZOBELLIA_1154 ZOBELLIA_1154 1379783 1381057 - Hypothetical lipoprotein Putatively contains a unique copy of LVIVD domain. This domain can be involved a beta propeller fold%3B Signal peptide of lipoprotein cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1154 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1154 ZOBELLIA_1155 ZOBELLIA_1155 ZOBELLIA_1155 1381171 1381902 - Hypothetical membrane protein Contains four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1155 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1155 ZOBELLIA_1156 ZOBELLIA_1156 ZOBELLIA_1156 1382045 1383490 + MiaB-like tRNA modifying protein Contains a N-terminal UPF0004 domain of unknown function%2C a Radical SAM superfamily%2C MiaB family domain involved in 2-methylthioadenine formation and a C-terminal TRAM domain predicted to bind tRNA and deliver the RNA-modifying enzymatic domain to their targets%3B Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (SAM)%3B Localized in the cytoplasm%3B~Family membership gene gene1156 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1156 ZOBELLIA_1157 ZOBELLIA_1157 ZOBELLIA_1157 1383520 1384788 + Sigma-54-dependent transcriptional regulator These transcriptional regulators consit of two domains: a N-terminal sigma 54 interaction domain that acts as an ATP binding domain (in its N-terminal part) and as sigma 54 binding domain with an ATPase activity (in its C-terminal part)%2C and a Fis-type helix-turn-helix DNA-binding domain in their C-terminal section%3B~Family membership gene gene1157 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1157 ZOBELLIA_1158 ZOBELLIA_1158 ZOBELLIA_1158 1384835 1385353 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer and/or cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1158 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1158 ZOBELLIA_1159 ZOBELLIA_1159 ZOBELLIA_1159 1385409 1386329 + Conserved hypothetical protein Localized in the cytoplasm. gene gene1159 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1159 ZOBELLIA_116 ZOBELLIA_116 ZOBELLIA_116 133535 134728 + Conserved hypothetical membrane protein Contains one C-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_116 ZOBELLIA_1160 ZOBELLIA_1160 secG secG 1386337 1386699 + Protein-export membrane protein secG SecG is a membrane subunit of the preprotein translocase complex. Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. The translocase itself comprises 7 proteins%2C including a chaperone protein (SecB)%2C an ATPase (SecA)%2C an integral membrane complex (SecCY%2C SecE and SecG)%2C and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF). Together with SecY and SecE%2C SecG forms a multimeric channel through which preproteins are translocated%2C using both proton motive forces and ATP-driven secretion. SecG has two transmembrane domains%2C both of which contribute to the recognition of preprotein signal sequences by the translocation complex. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1160 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1160 ZOBELLIA_1161 ZOBELLIA_1161 groS groS 1386845 1387123 + 10 kDa chaperonin The 10 kDa chaperonin%2C also known as GroES protein%2C binds to the 60 kDa chaperonin (GroEL) in the presence of Mg-ATP and suppresses the ATPase activity of the latter. It forms a heptamer of 7 subunits arranged in a ring. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1161 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1161 ZOBELLIA_1162 ZOBELLIA_1162 groL groL 1387230 1388861 + 60 kDa chaperonin The 60 kDa chaperonin%2C also knonwn as GroEL protein%2C prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. It is essential for the growth of the bacteria. It forms an oligomer of 14 subunits composed of two stacked rings of 7 subunits. This ring structure assembles by self-stimulation in the presence of Mg2+-ATP. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1162 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1162 ZOBELLIA_1163 ZOBELLIA_1163 ZOBELLIA_1163 1388951 1389151 + Putative protein Hypothetical protein gene gene1163 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1163 ZOBELLIA_1164 ZOBELLIA_1164 ZOBELLIA_1164 1389280 1389636 - Metal transport-related protein Seems to contain a Heavy metal associated domain (HMA domain) being involved in bacterial resistance to toxic metals%3B Signal peptide cleaved between the residues 19 and 20%3B Exported in the periplasmic space%3B~Conserved hypothetical protein gene gene1164 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1164 ZOBELLIA_1165 ZOBELLIA_1165 ZOBELLIA_1165 1389661 1391898 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-98) and the Plug module (115-222) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene1165 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1165 ZOBELLIA_1166 ZOBELLIA_1166 actP actP 1391916 1394411 - Copper-transporting P-type ATPase ActP is a P-type ATPase responsible for copper efflux using ATP hydrolysis for energy. ActP controls copper homeostasis. Belongs to the cation transport P-type ATPase family. Features eight transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1166 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1166 ZOBELLIA_1167 ZOBELLIA_1167 ZOBELLIA_1167 1394485 1395003 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA. Also would contain an N-terminal heavy-metal-associated domain (HMA) involved in the transport or detoxification of heavy metals%3B Localized in the cytoplasm%3B~Family membership gene gene1167 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1167 ZOBELLIA_1168 ZOBELLIA_1168 ZOBELLIA_1168 1395149 1395562 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1168 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1168 ZOBELLIA_1169 ZOBELLIA_1169 ZOBELLIA_1169 1395800 1396876 + Hypothetical lipoprotein Lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1169 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1169 ZOBELLIA_117 ZOBELLIA_117 ZOBELLIA_117 134809 135564 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_117 ZOBELLIA_1170 ZOBELLIA_1170 ZOBELLIA_1170 1396978 1397436 + Conserved hypothetical protein Contains a GAF domain%3B Localized in the cytoplasm gene gene1170 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1170 ZOBELLIA_1171 ZOBELLIA_1171 purH purH 1397610 1399139 + Bifunctional purine biosynthesis protein PurH Bifunctional enzyme that catalyses the last two steps in de novo purine biosynthesis. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) formyltransferase that catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield 5-formylaminoimidazole-4-carboxamide ribonucleotide (FAICAR) and tetrahydrofolate. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase%2C cyclizing FAICAR to IMP%3B Belongs to the purH family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1171 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1171 ZOBELLIA_1172 ZOBELLIA_1172 mreB mreB 1399207 1400235 + Rod shape-determining protein MreB MreB is involved in formation of the rod shape of the cell. It may act as a negative regulator of ftsI%3B Belongs to the FtsA/MreB family%3B Localized in the cytoplasm close to the cell surface%2C forming filamentous helical structures in the same orientation like F-actin%3B~High confidence in function and specificity gene gene1172 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1172 ZOBELLIA_1173 ZOBELLIA_1173 mreC mreC 1400322 1401143 + Rod shape-determining protein MreC MreC (murein formation C) is involved in the rod shape determination and more generally in cell shape determination of bacteria whether or not they are rod-shaped%3B Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1173 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1173 ZOBELLIA_1174 ZOBELLIA_1174 mreD mreD 1401133 1401642 + Possible rod shape-determining protein MreD Hypothetical protein that could be MreD (murein formation D) involved in formation of the rod shape of the cell%3B Contains six transmembrane segments%3B Localized in the cytoplasmic memnbrane%3B~Conserved hypothetical protein gene gene1174 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1174 ZOBELLIA_1175 ZOBELLIA_1175 mrdA mrdA 1401689 1403557 + Penicillin-binding protein 2%2C Family GT51 PBP-2 is responsible for the determination of the rod shape of the cel. Synthetizes the cross-linked peptidoglycan from the lipid intermediates%3B Contains in its N-terminal half part a transmembrane segment and an penicillin insensitive transglycosylase domain (formation of linear glycan strands). In its C-terminal half part%2C a penicillin- sensitive transpeptidase domain (cross-linking of the peptide subunits) is present%3B Belongs to the family 51 of glycosyl transferases (GT51)%3B Except for the cytoplasmic membrane anchor region%2C The bulk of the molecule protrudes into the periplasmic space%2C where it acts on murein%3B~High confidence in function and specificity gene gene1175 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1175 ZOBELLIA_1176 ZOBELLIA_1176 mrdB mrdB 1403547 1404830 + Rod shape-determining protein RodA MrdB (RodA) is one of the proteins responsible for the rod shape of the cell. Is required for the expression of the enzymatic activity of the penicillin binding protein 2 (MrdA)%2C which is thought to synthesize peptidoglycan in the step of initiation of cell elongation%3B Contains ten transmembrane segments%3B Belongs to the FtsW/RodA/SpoVE family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1176 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1176 ZOBELLIA_1177 ZOBELLIA_1177 ZOBELLIA_1177 1404876 1405682 - DNA/RNA non-specific endonuclease Endonuclease acting on both DNA and RNA. Cleaves double-stranded and single-stranded nucleic acids and requires a divalent ion such as magnesium for its activity. A histidine has been shown to be essential for the activity%2C located in a conserved region which also contains an aspartate that could be implicated in the binding of the divalent ion%3B Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1177 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1177 ZOBELLIA_1178 ZOBELLIA_1178 msrB2 msrB2 1405944 1406402 + Peptide methionine sulfoxide reductase msrB Peptide methionine sulphoxide reductase reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide to methionine. MsrB is specific for methionine-R-sulfoxides. It activates the cysteine or selenocysteine nucleophile through a unique Cys-Arg-Asp/Glu catalytic triad. Regeneration of the active site occurs through a series of thiol-disulfide exchange steps involving another active site Cys residue and thioredoxin. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1178 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1178 ZOBELLIA_1179 ZOBELLIA_1179 msrA1 msrA1 1406399 1406956 + Peptide methionine sulfoxide reductase msrA Peptide methionine sulphoxide reductase reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide to methionine. MsrA is specific for methionine-S-sulfoxides. Though their active sites show approximate mirror symmetry%2C MsrA and MsrB are structurally unrelated. In each case%2C conserved amino acid motifs mediate the stereo-specific recognition and reduction of the substrate. Thioredoxin acts as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1179 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1179 ZOBELLIA_118 ZOBELLIA_118 ZOBELLIA_118 135595 135933 - Conserved hypothetical protein Contains two transmembrane segments%3B Probably localized in the cytoplasmic membrane gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_118 ZOBELLIA_1180 ZOBELLIA_1180 ZOBELLIA_1180 1407063 1407476 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1180 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1180 ZOBELLIA_1181 ZOBELLIA_1181 msrA2 msrA2 1407602 1408090 + Peptide methionine sulfoxide reductase msrA Peptide methionine sulphoxide reductase reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide to methionine. MsrA is specific for methionine-S-sulfoxides. Though their active sites show approximate mirror symmetry%2C MsrA and MsrB are structurally unrelated. In each case%2C conserved amino acid motifs mediate the stereo-specific recognition and reduction of the substrate. Thioredoxin acts as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1181 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1181 ZOBELLIA_1182 ZOBELLIA_1182 alyA1 alyA1 1408423 1409763 + Alginate lyase%2C family PL7 Modular protein with a N-terminal carbohydrate binding module of the family 32 (CBM32) and a C-terminal alginate lyase domain of the family 7 of the polysaccharide lyases (PL7). Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D- mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. Features a signal peptide cleaved between residues 34 and 35. Likely localized in the outer membrane.%3B~High confidence in function and specificity gene gene1182 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1182 ZOBELLIA_1183 ZOBELLIA_1183 ZOBELLIA_1183 1409904 1412027 - Carboxy-terminal processing peptidase%2C family S41 This enzyme is a modular protein with a N-terminal domain of unknown function%2C a central PDZ domain that is a multifunctional protein-protein interaction module binding to a signature motif ([FYST]-X-[FVA]) occurring at the very C-terminus of target proteins and a Carboxy-terminal processing peptidase in C-terminus that shows a specific recognition of a C-terminal tripeptide%2C Xaa-Yaa-Zaa%2C in which Xaa is preferably Ala or Leu%2C Yaa is preferably Ala or Tyr%2C and Zaa is preferably Ala%2C but then cleaves at a variable distance from the C-terminus of the target proteins%3B The catalytic module belongs to the family S41 of the peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the rsidues 18 and 19%3B Localized in the outer membrane%3B~Specificity unclear gene gene1183 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1183 ZOBELLIA_1184 ZOBELLIA_1184 surE surE 1412227 1413006 + Stationary-phase survival protein surE SurE is a nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20- 25). Might be involved in the regulation of dNTP and NTP pools%2C and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1%2C T2%2C and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the bacterial survival in stationary growth phase. Binds 1 divalent metal cation as a cofactor. Localized in the cytoplasm.%3B~Hypothetical protein gene gene1184 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1184 ZOBELLIA_1185 ZOBELLIA_1185 ZOBELLIA_1185 1413071 1413355 + Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1185 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1185 ZOBELLIA_1186 ZOBELLIA_1186 lpxB lpxB 1413448 1414560 + Lipid-A-disaccharide synthase%2C family GT19 LpxB catalyzes the condensation of UDP-2%2C3-diacylglucosamine and 2%2C3-diacylglucosamine-1-phosphate to form lipid A disaccharide. This reaction is the fifth step of lipid A biosynthesis. LpxB belongs to the family 19 of the glycosyltransferases. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1186 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1186 ZOBELLIA_1187 ZOBELLIA_1187 sprA sprA 1414553 1415161 + Peptidase spr%2C family C40 The lipoprotein sprA was identified by genetic as a suppressor of a protease prc mutation. Its exact function is not known. The catalytic dyad is formed by a single conserved cysteine and histidine residues%3B Belongs to the family C40 of peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 34 and 35%3B Localized in the cytoplasmic or outer membrane%3B~Specificity unclear gene gene1187 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1187 ZOBELLIA_1188 ZOBELLIA_1188 ZOBELLIA_1188 1415172 1417190 + Competence protein Competence proteins are essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. This competence protein features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1188 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1188 ZOBELLIA_1189 ZOBELLIA_1189 dtpT dtpT 1417212 1418582 - Di-/tripeptide transporter DtpT a membrane permease responsible for the intake of di- or tri-peptides with the concomitant uptake of a proton. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1189 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1189 ZOBELLIA_119 ZOBELLIA_119 ZOBELLIA_119 135974 136267 - Conserved hypothetical membrane protein Contains two transmembrane segments%3B Probably localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_119 ZOBELLIA_1190 ZOBELLIA_1190 dppA1 dppA1 1418710 1420890 - Dipeptidyl-peptidase IV%2C family S9 Dipeptidyl-peptidase IV releases an N-terminal dipeptide%2C Xaa-Yaa-|-Zaa-%2C from a polypeptide%2C preferentially when Yaa is Pro%2C provided Zaa is neither Pro nor hydroxyproline. Belongs to the family S9 of the serine peptidases. The active site residues are in the order Ser%2C Asp%2C His in the sequence. The motif around the active site serine is G W S (Y/F) G G. DppA displays a two domain architecture%2C with a N-terminal eight-bladed beta-propeller and a C-terminal S9 peptidase domain. Features a signal peptide cleaved between the residues 20 and 21. Localized in the periplasm.%3B~High confidence in function and specificity gene gene1190 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1190 ZOBELLIA_1191 ZOBELLIA_1191 mvaA mvaA 1421044 1422366 + 3-Hydroxy-3-methylglutaryl-coenzyme A reductase 3-Hydroxy-3-methylglutaryl-coenzyme A reductase catalyzes the reversible conversion of mevalonate into 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)%2C using coenzyme A and NAD(P) as cofactors. In Archeae%2C NADP-depedent HMG-CoA reductase is involved in the biosynthesis of the isoprenoids side chains of lipids. Some bacteria%2C such as Pseudomonas mevalonii%2C use an NAD-dependent HMG-CoA reductase to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. These bacteria can use mevalonate as sole carbon source. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1191 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1191 ZOBELLIA_1192 ZOBELLIA_1192 ZOBELLIA_1192 1422363 1423277 + GHMP kinase family protein Protein that is probably a kinase%3B belongs to the GHMP (galacto%2C homoserine%2C mevalonate%2C phosphomevalonate) kinase family%3B Localized in the cytoplasm%3B~Family membership gene gene1192 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1192 ZOBELLIA_1193 ZOBELLIA_1193 ZOBELLIA_1193 1423338 1425455 - Peptidyl-prolyl isomerase family protein Large conserved protein distantly related to peptidyl-prolyl cis-trans isomerase%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1193 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1193 ZOBELLIA_1194 ZOBELLIA_1194 ZOBELLIA_1194 1425525 1426814 - CBS family protein Conserved protein that contains a N-terminal transmembrane region of unknown function belonging to the DUF21 family%2C composed of four helices%2C two central cystathionine-beta-synthase (CBS) domains and a C-terminal transporter associated domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP%2C ATP and S-AdoMet. They may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The function of the transporter associated domain is uncertain but might be involved in modulating transport of ion substrates%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1194 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1194 ZOBELLIA_1195 ZOBELLIA_1195 ZOBELLIA_1195 1426817 1427020 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1195 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1195 ZOBELLIA_1196 ZOBELLIA_1196 ZOBELLIA_1196 1427013 1427621 - Conserved hypothetical protein Localized in the cytoplasm gene gene1196 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1196 ZOBELLIA_1197 ZOBELLIA_1197 ZOBELLIA_1197 1427626 1428999 - TPR repeats protein Conserved protein containing three tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Family membership gene gene1197 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1197 ZOBELLIA_1198 ZOBELLIA_1198 ZOBELLIA_1198 1429241 1430527 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1198 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1198 ZOBELLIA_1199 ZOBELLIA_1199 coaX coaX 1430527 1431315 - Type III pantothenate kinase Type III pantothenate kinase catalyzes the phosphorylation of pantothenate%2C the first step in coenzyme A biosynthesis. Can not utilize a phosphoryl donor other than ATP. It forms a homodimer and binds ammonium or potassium as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1199 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1199 ZOBELLIA_12 ZOBELLIA_12 trmD trmD 10941 11615 + tRNA (guanine-N1-)-methyltransferase The tRNA (guanine-N1-)-methyltransferase catalyses the methylation of guanoside (G) to N1-methylguanosine (m1G) at position 37%2C next to the anticodon%2C of tRNAs that read CUN (leucine)%2C CCN(proline)%2C and CGG (arginine) codons%3B Belongs to the tRNA methyltransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_12 ZOBELLIA_120 ZOBELLIA_120 ZOBELLIA_120 136413 137756 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains four and two transmembrane segments in the N- and C- terminal domain respectively%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_120 ZOBELLIA_1201 ZOBELLIA_1201 ZOBELLIA_1201 1432468 1433772 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 15 and 16%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1201 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1201 ZOBELLIA_1202 ZOBELLIA_1202 glpE4 glpE4 1433840 1434337 + Thiosulfate sulfurtransferase Thiosulfate sulfurtransferase catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate%3B Contains one only rhodanese domain%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene1202 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1202 ZOBELLIA_1203 ZOBELLIA_1203 ZOBELLIA_1203 1434398 1435075 + Conserved hypothetical protein Localized in the cytoplasm gene gene1203 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1203 ZOBELLIA_1204 ZOBELLIA_1204 punA punA 1435072 1435887 + Purine nucleoside phosphorylase Purine nucleoside phosphorylase is involved in Nucleoside catabolism. It catalyzes the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1204 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1204 ZOBELLIA_1205 ZOBELLIA_1205 ZOBELLIA_1205 1435977 1436747 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1205 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1205 ZOBELLIA_1206 ZOBELLIA_1206 ZOBELLIA_1206 1436734 1437438 + Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene1206 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1206 ZOBELLIA_1207 ZOBELLIA_1207 ZOBELLIA_1207 1437435 1438508 - N-Acetylmuramoyl-L-alanine amidase N-Acetylmuramoyl-L-alanine amidase hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in peptidoglycan%3B Contains a signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene1207 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1207 ZOBELLIA_1208 ZOBELLIA_1208 ZOBELLIA_1208 1438699 1439580 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1208 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1208 ZOBELLIA_1209 ZOBELLIA_1209 ZOBELLIA_1209 1439644 1440681 - FAD-dependent amine oxidoreductase FAD-dependent amine oxidoreductase of unknown substrate specificity%3B Belongs to the amine oxydase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1209 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1209 ZOBELLIA_121 ZOBELLIA_121 ZOBELLIA_121 137883 138344 - AsnC/Lrp-type transcriptional regulator The AsnC/Lrp-type transcriptional regulator family appears to be an important regulatory system of the amino acid metabolism and related processes%3B Contains a N-terminal DNA binding AsnC/Lrp-type HTH domain. The C-terminal part contains an effector-binding domain and/or an oligomerization domain%3B Localized in the cytoplasm%3B~Family membership gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_121 ZOBELLIA_1210 ZOBELLIA_1210 ZOBELLIA_1210 1440684 1440986 - Carboxymuconolactone decarboxylase family protein The exact function of this conserved protein is not known%3B belongs to the carboxymuconolactone decarboxylase family%3B Localized in the cytoplasm%3B~Family membership gene gene1210 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1210 ZOBELLIA_1211 ZOBELLIA_1211 hdhA hdhA 1441082 1441828 - 7-Alpha-hydroxysteroid dehydrogenase HdhA catalyzes the 7-alpha-dehydroxylation of cholic acid%2C yielding deoxycholic acid and lithocholic acid%2C respectively. Highest affinity with taurochenodeoxycholic acid. It forms a homotetramer and binds one NAD cofactor by subunit. Belongs to the short chain dehydrogenase family. Localized in the cytoplasm.%3B~Hypothetical protein gene gene1211 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1211 ZOBELLIA_1212 ZOBELLIA_1212 ZOBELLIA_1212 1441980 1442612 + Conserved hypothetical protein Localized in the cytoplasm gene gene1212 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1212 ZOBELLIA_1213 ZOBELLIA_1213 ZOBELLIA_1213 1442621 1443424 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1213 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1213 ZOBELLIA_1214 ZOBELLIA_1214 defB defB 1443527 1444057 + Formylmethionine deformylase Formylmethionine deformylase or peptide deformylase (PDF) is an essential metalloenzyme required for the removal of the formyl group at the N-terminal Met of nascent polypeptide chains in eubacteria. The enzyme acts as a monomer and binds a single zinc ion. Catalytic efficiency strongly depends on the identity of the bound metal%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1214 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1214 ZOBELLIA_1215 ZOBELLIA_1215 ZOBELLIA_1215 1444058 1445323 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1215 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1215 ZOBELLIA_1216 ZOBELLIA_1216 ZOBELLIA_1216 1445405 1446124 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1216 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1216 ZOBELLIA_1217 ZOBELLIA_1217 ZOBELLIA_1217 1446126 1447127 - Glycoside hydrolase%2C family GH113 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety%3B Belongs to the family 13 of the glycoside hydrolases%3B Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Specificity unclear gene gene1217 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1217 ZOBELLIA_1218 ZOBELLIA_1218 ZOBELLIA_1218 1447174 1448058 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1218 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1218 ZOBELLIA_1219 ZOBELLIA_1219 ZOBELLIA_1219 1448092 1448811 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1219 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1219 ZOBELLIA_122 ZOBELLIA_122 metE metE 138504 140828 + 5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase The vitamin-B12 independent methionine synthase catalyzes the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to homocysteine. It binds one zinc ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_122 ZOBELLIA_1220 ZOBELLIA_1220 ZOBELLIA_1220 1449045 1450418 + FAD-dependent pyridine nucleotide-disulfide oxidoreductase The pyridine nucleotide-disulphide reductases use the isoalloxazine ring of FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step%2C the reduced disulphide reduces the substrate%3B Uses the FAD as cofactors%3B Contains a N-terminal Pyridine nucleotide-disulphide oxidoreductase domain%3B Belongs to the family of pyridine nucleotide-disulphide oxidoreductases%3B Localized in the cytoplasm%3B~Family membership gene gene1220 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1220 ZOBELLIA_1221 ZOBELLIA_1221 ZOBELLIA_1221 1450499 1452079 + (2[4Fe-4S])-containing oxidoreductase Oxidoreductase which contains two 4Fe-4S binding domains and eight transmembrane segemnts%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1221 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1221 ZOBELLIA_1222 ZOBELLIA_1222 ZOBELLIA_1222 1452173 1452655 + Conserved hypothetical protein Localized in the cytoplasm gene gene1222 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1222 ZOBELLIA_1223 ZOBELLIA_1223 rhaB rhaB 1452652 1455051 + Alpha-L-rhamnosidase%2C family GH78 Alpha-L-rhamnosidase catalyzes the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. It belongs to the family 78 of the glycoside hydrolases. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1223 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1223 ZOBELLIA_1224 ZOBELLIA_1224 ZOBELLIA_1224 1455061 1455756 + Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene1224 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1224 ZOBELLIA_1225 ZOBELLIA_1225 ZOBELLIA_1225 1455758 1457242 + Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases and is closely related to the cellulose/mannan/chitin synthase subfamily. Features one N-terminal transmembrane helix and five C-terminal transmembrane helices. Integral cytoplasmic membrane protein.%3B~Specificity unclear gene gene1225 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1225 ZOBELLIA_1226 ZOBELLIA_1226 ZOBELLIA_1226 1457310 1458671 + Conserved hypothetical membrane protein Contains eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1226 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1226 ZOBELLIA_1227 ZOBELLIA_1227 ZOBELLIA_1227 1458890 1459510 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule. Belongs to Gcn5 or GNAT actyltransferase family. Localized in the cytoplasm.%3B~Family membership gene gene1227 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1227 ZOBELLIA_1228 ZOBELLIA_1228 argG argG 1459565 1460755 + Argininosuccinate synthase Argininosuccinate synthase (AS) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate%2C AMP and pyrophosphate%3B Belongs to the argininosuccinate synthase family%2C type 1 subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1228 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1228 ZOBELLIA_1229 ZOBELLIA_1229 argC argC 1460748 1461722 + N-acetyl-gamma-glutamyl-phosphate reductase N-acetyl-gamma-glutamyl-phosphate reductase is involved in the third step of the arginine biosynthesis pathway. It converts%2C in presence of NADP%2C the N-acetyl-L-glutamate 5-semialdehyde to N-acetyl-5-glutamyl phosphate%3B Belongs to the NAGSA dehydrogenase family%2C type 1 subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1229 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1229 ZOBELLIA_123 ZOBELLIA_123 ZOBELLIA_123 140915 142468 + FAD-dependent oxidoreductase Conserved FAD-dependent oxidoreductase. Its exact specificity is unknown. Localized in the cytoplasm.%3B~Specificity unclear gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_123 ZOBELLIA_1230 ZOBELLIA_1230 proC2 proC2 1461794 1462594 + Pyrroline-5-carboxylate reductase Delta 1-pyrroline-5-carboxylate reductase (P5CR) is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate: the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1230 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1230 ZOBELLIA_1231 ZOBELLIA_1231 argD argD 1462649 1463773 + Acetylornithine aminotransferase Acetylornithine aminotransferase catalyzes the transfer of an amino group from acetylornithine to alpha-ketoglutarate%2C yielding N-acetyl-glutamic-5-semi-aldehyde and glutamic acid. This is the fourth step in the arginine biosynthesis pathway. ArgD is also involved in the urea cycle. This enzyme uses the pyridoxal phosphate as cofactor linked to a conserved lysine residue. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1231 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1231 ZOBELLIA_1232 ZOBELLIA_1232 proA2 proA2 1463773 1464972 + Gamma-glutamyl phosphate reductase Gamma-glutamyl phosphate reductase (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate: the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate%3B Belongs to the aldehyde dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1232 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1232 ZOBELLIA_1233 ZOBELLIA_1233 proB2 proB2 1465036 1465824 + Glutamate 5-kinase Glutamate 5-kinase catalyses the first step in the biosynthesis of proline: the ATP-dependent phosphorylation of glutamate to glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline%3B It belongs to the larger family of aspartokinases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1233 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1233 ZOBELLIA_1234 ZOBELLIA_1234 argF' argF' 1465873 1466808 + N-acetylornithine carbamoyltransferase N-acetylornithine carbamoyltransferase catalyzes the convertion of N-acetylornithine to N-acetylcitrulline and has no catalytic activity with L-ornithine as substrate. ArgF' does not feature the SMG motif which is conserved in the canonical ArgF (L-ornithine to L- citrulline). In this alternative pathway%2C N-acetyl-L- citrulline is likely deacetylated by ArgE%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1234 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1234 ZOBELLIA_1235 ZOBELLIA_1235 argB argB 1466813 1467586 + Acetylglutamate kinase Acetylglutamate kinase is involved in the second step of the arginine biosynthesis pathway. It converts%2C in presence of ATP%2C the N-acetyl-L-glutamate to N-acetyl-L-glutamate 5-phosphate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1235 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1235 ZOBELLIA_1236 ZOBELLIA_1236 argE argE 1467589 1468659 + Acetylornithine deacetylase%2C family M20A Acetylornithine deacetylase catalyzes the fifth step of the arginine biosynthesis pathway%2C converting the 2-N-acetyl-L-ornithine to L-ornithine and acetate. L-ornithine is also a branchpoint in the synthesis of polyamines. ArgE binds two zinc ions per monomer of protein%3B Belongs to the family M20A of the metallopeptidases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1236 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1236 ZOBELLIA_1237 ZOBELLIA_1237 argH argH 1468736 1470016 + Argininosuccinate lyase Argininosuccinate lyase is involved in the eighth and last step of the arginine biosynthesis pathway. It converts the Omega-N-(L-arginino)succinate to fumarate and L-arginine%3B Belongs to the fumarate lyase family. Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1237 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1237 ZOBELLIA_1238 ZOBELLIA_1238 ZOBELLIA_1238 1470048 1471652 + Aminopeptidase%2C family M1 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. This enzyme belongs to the family M1 of the peptidases. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Features a signal peptide cleaved between the residues 25 and 26. Localized in the periplasm.%3B~Specificity unclear gene gene1238 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1238 ZOBELLIA_1239 ZOBELLIA_1239 rluB rluB 1471852 1472556 - Ribosomal large subunit pseudouridine synthase B Enzyme responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Contains a N-terminal S4 RNA-binding domain that probably mediates binding to RNA.%3B Belongs to the pseudouridine synthase RsuA family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene1239 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1239 ZOBELLIA_124 ZOBELLIA_124 rhlE rhlE 142525 143826 + RNA helicase RhlE The ATP-dependent RNA helicase RhlE interacts with the Poly(A) polymerase. It is nonessential for bacterial cell growth%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%2C DEAD box subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_124 ZOBELLIA_1240 ZOBELLIA_1240 nitA nitA 1472723 1473673 - Nitrilase Nitrilases%2C involved in the reduction of organic nitrogen compounds and ammonia production%2C are enzymes that convert nitriles into their corresponding acids and ammonia by cleavage of the carbon-nitrogen bonds. They acts on a wide range of aromatic nitriles including (indol- 3-yl)-acetonitrile%2C and also on some aliphatic nitriles%2C and on the corresponding acid amides%3B Belongs to the CN hydrolase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1240 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1240 ZOBELLIA_1241 ZOBELLIA_1241 ZOBELLIA_1241 1473673 1474578 - Prenyltransferase family protein Multi-pass membrane protein that contains eight transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1241 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1241 ZOBELLIA_1242 ZOBELLIA_1242 mvkA mvkA 1474591 1475529 - Mevalonate kinase Mevalonate kinase catalyses the phosphorylation of mevalonate to phosphomevalonate from AT as donor%3B Uses the magnesium ions as cofactor%3B CTP%2C GTP and UTP can also act as donors%3B Belongs to the GHMP kinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1242 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1242 ZOBELLIA_1243 ZOBELLIA_1243 mvdA mvdA 1475812 1476897 - Mevalonate diphosphate decarboxylase Mevalonate diphosphate decarboxylase or diphosphomevalonate decarboxylase catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP)%2C the last step in the synthesis of IPP in the mevalonate pathway. Mevalonate is a key intermediate in the biosynthesis of sterols and non-sterol isoprenes%3B Belongs to the GHMP kinase domain superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1243 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1243 ZOBELLIA_1244 ZOBELLIA_1244 crtK crtK 1476990 1477463 + Protein CrtK Protein possibly involved in the carotenoid biosynthesis%3B Contains five transmembrane segments%3B Belongs to the TspO/BZRP family%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1244 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1244 ZOBELLIA_1245 ZOBELLIA_1245 ZOBELLIA_1245 1477471 1478010 - Conserved hypothetical protein Protein of unknown function%3B Belongs to the DUF1697 family%3B Localized in the cytoplasm gene gene1245 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1245 ZOBELLIA_1246 ZOBELLIA_1246 ZOBELLIA_1246 1478007 1479293 - Flavoprotein This is a family that may include proteins with a dinucleotide-binding motif (Rossman fold)%2C including oxidoreductases and dehydrogenases%3B Seems to contain a FAD binding domain also found in the pyridine nucleotide-disulphide reductases (PNDR)%3B Localized in the cytoplasm%3B~Function unclear gene gene1246 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1246 ZOBELLIA_1247 ZOBELLIA_1247 glpQ glpQ 1479293 1480042 - Glycerophosphoryl diester phosphodiesterase Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols%3B Signal peptide of lipoprotein cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene1247 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1247 ZOBELLIA_1248 ZOBELLIA_1248 ZOBELLIA_1248 1480049 1481827 - Glycoside hydrolase%2C family GH13 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. Belongs to the family 13 of the glycoside hydrolases.%3B~Specificity unclear gene gene1248 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1248 ZOBELLIA_1249 ZOBELLIA_1249 mapA mapA 1481831 1484134 - Maltose phosphorylase%2C family GH65 Maltose phosphorylase catalyzes the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. It belongs to the family 65 of the glycoside hydrolases. Involved in the maltose metabolism.%3B~High confidence in function and specificity gene gene1249 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1249 ZOBELLIA_125 ZOBELLIA_125 ZOBELLIA_125 143823 144017 - Putative protein Hypothetical protein gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_125 ZOBELLIA_1250 ZOBELLIA_1250 pgmB pgmB 1484170 1484832 - Beta-phosphoglucomutase Beta-phosphoglucomutase is involved in maltose metabolism. It catalyzes the reversible transformation of glucose 6-phosphate and beta-glucose 1-phosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1250 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1250 ZOBELLIA_1251 ZOBELLIA_1251 ZOBELLIA_1251 1484906 1485940 - LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene1251 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1251 ZOBELLIA_1252 ZOBELLIA_1252 ZOBELLIA_1252 1486287 1489412 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (24-97) and the Plug module (113-240) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~Family membership gene gene1252 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1252 ZOBELLIA_1253 ZOBELLIA_1253 ZOBELLIA_1253 1489423 1490997 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Probably localized in the outer membrane%3B~Family membership gene gene1253 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1253 ZOBELLIA_1254 ZOBELLIA_1254 ZOBELLIA_1254 1491104 1492255 - Conserved hypothetical membrane protein Contains a central transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1254 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1254 ZOBELLIA_1255 ZOBELLIA_1255 bgaD bgaD 1492467 1495313 + Beta-galactosidase%2C family GH2 Enzyme belonging to the family 2 of glycoside hydrolases (GH2) which catalyzes the hydrolysis of the beta-1%2C4 linkage at the terminal non-reducing of beta-D-galactosides%2C releasing a beta-D-galactose residue%3B Signal peptide cleaved between residues 22 and 23%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene1255 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1255 ZOBELLIA_1256 ZOBELLIA_1256 dnaE2 dnaE2 1495590 1498568 + DNA polymerase III%2C alpha chain The alpha subunit of DNA polymerase III is responsible of the polymerase activity%3B Contains a N-terminal PHP domain (phosphoesterase) and a C-terminal OB module (oligonucleotide/oligosaccharide-binding fold) involved in the DNA binding%3B The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1256 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1256 ZOBELLIA_1257 ZOBELLIA_1257 dinB2 dinB2 1498561 1499778 + DNA polymerase IV The DNA polymerase IV is a poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. It copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis%2C in conjunction with the beta clamp from polIII%3B Induced by SOS response%3B Contains a umuC domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1257 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1257 ZOBELLIA_1258 ZOBELLIA_1258 ZOBELLIA_1258 1499894 1501546 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of pro-and eukaryotic cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1258 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1258 ZOBELLIA_1259 ZOBELLIA_1259 ZOBELLIA_1259 1501719 1505042 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins. The FG-GAP repeat has been predicted to fold into a beta propeller structure. The FG- GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B Contains a signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Protein putatively localized in the cytoplasmic membrane%3B~Function unclear gene gene1259 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1259 ZOBELLIA_126 ZOBELLIA_126 ZOBELLIA_126 144026 144859 + Endonuclease/exonuclease/phosphatase family The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling%3B Belongs to the Endonuclease/Exonuclease/ phosphatase family%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Family membership gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_126 ZOBELLIA_1260 ZOBELLIA_1260 ZOBELLIA_1260 1505044 1508403 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins%3B The FG-GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B The FG-GAP repeat has been predicted to fold into a beta propeller structure%3B Contains a signal peptide of lipoprotein cleaved between the residues 25 and 26%3B Protein putatively localized in the outer membrane%3B~Function unclear gene gene1260 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1260 ZOBELLIA_1261 ZOBELLIA_1261 ZOBELLIA_1261 1508404 1511709 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins%3B The FG-GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B The FG-GAP repeat has been predicted to fold into a beta propeller structure%3B Contains a signal peptide of lipoprotein cleaved between the residues 34 and 35%3B Protein putatively localized in the cytoplasmic membrane%3B~Function unclear gene gene1261 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1261 ZOBELLIA_1262 ZOBELLIA_1262 ZOBELLIA_1262 1511717 1513069 + Vanadium-dependent haloperoxidase Vanadium-dependent Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide%2C which results in subsequent halogenation of organic substrates%2C or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products%2C such as volatile halogenated hydrocarbons%2C chiral halogenated terpenes%2C acetogenins and indoles%3B Lipoprotein signal peptide cleaved between the residues 16 and 17%3B localized in the outer membrane%3B~Specificity unclear gene gene1262 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1262 ZOBELLIA_1263 ZOBELLIA_1263 ZOBELLIA_1263 1513076 1513975 + Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1263 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1263 ZOBELLIA_1264 ZOBELLIA_1264 ZOBELLIA_1264 1514014 1514880 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1264 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1264 ZOBELLIA_1265 ZOBELLIA_1265 ZOBELLIA_1265 1514888 1518640 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 30 and 31%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1265 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1265 ZOBELLIA_1266 ZOBELLIA_1266 ZOBELLIA_1266 1518653 1519855 + Conserved hypothetical membrane protein Contains three C-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1266 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1266 ZOBELLIA_1267 ZOBELLIA_1267 ZOBELLIA_1267 1519852 1522233 - Conserved hypothetical protein Localized in the cytoplasm gene gene1267 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1267 ZOBELLIA_1268 ZOBELLIA_1268 ZOBELLIA_1268 1522347 1523249 + Conserved hypothetical protein Localized in the cytoplasm gene gene1268 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1268 ZOBELLIA_1269 ZOBELLIA_1269 ZOBELLIA_1269 1523295 1523945 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1269 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1269 ZOBELLIA_127 ZOBELLIA_127 ZOBELLIA_127 144927 145757 - Non-heme haloperoxidase Haloperoxidase acting with chlore or bromide ions%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine and to the bacterial non-heme bromo- and chloro-peroxidases family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_127 ZOBELLIA_1270 ZOBELLIA_1270 ZOBELLIA_1270 1524139 1525566 + Conserved hypothetical periplasmic protein Conserved protein belonging to the DUF1593 family%3B Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space and possibly secreted%3B~Family membership gene gene1270 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1270 ZOBELLIA_1271 ZOBELLIA_1271 ZOBELLIA_1271 1525688 1526092 + OsmC-like protein Conserved protein belonging to the OsmC family possibly involved in the response to stress%3B Localized in the cytoplasm%3B~Family membership gene gene1271 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1271 ZOBELLIA_1272 ZOBELLIA_1272 ZOBELLIA_1272 1526163 1527041 + Glycoside hydrolase%2C family GH114 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. Belongs to the family 114 of the glycoside hydrolases. Family GH114 contains endo-alpha-1%2C4-polygalactosaminidases%2C but the specificity of this protein is unclear. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 29 and 30. Localized in the outer membrane.%3B~Specificity unclear gene gene1272 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1272 ZOBELLIA_1273 ZOBELLIA_1273 ZOBELLIA_1273 1527113 1527892 + Conserved hypothetical protein Localized in the cytoplasm gene gene1273 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1273 ZOBELLIA_1274 ZOBELLIA_1274 ZOBELLIA_1274 1527882 1528268 + Conserved hypothetical protein Localized in the cytoplasm gene gene1274 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1274 ZOBELLIA_1275 ZOBELLIA_1275 ZOBELLIA_1275 1528570 1529703 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains an N- terminal PAS/PAC domain involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene1275 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1275 ZOBELLIA_1276 ZOBELLIA_1276 ZOBELLIA_1276 1529783 1530418 + Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene1276 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1276 ZOBELLIA_1277 ZOBELLIA_1277 ZOBELLIA_1277 1530485 1531414 + Pirin-like protein Conserved protein highly Belongs to the Fe(II)-containing member of the Cupin superfamily%3B Localized in the cytoplasm.%3B~Function unclear gene gene1277 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1277 ZOBELLIA_1278 ZOBELLIA_1278 ZOBELLIA_1278 1531420 1531623 + Conserved hypothetical protein Conserved protein belonging to the DUF1271 family. Members of this family contain three highly conserved cysteine residues. The function of this family is unknown. Localized in the cytoplasm.%3B~Family membership gene gene1278 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1278 ZOBELLIA_1279 ZOBELLIA_1279 ZOBELLIA_1279 1531848 1532249 + Conserved hypothetical protein Localized in the cytoplasm gene gene1279 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1279 ZOBELLIA_128 ZOBELLIA_128 paiB paiB 145898 146503 + Transcriptional regulator PaiB PaiB is a transcriptional regulator with a helix-turn-helix domain and a FMN-binding domain. In Bacillus subtilis%2C PaiB is Involved in the reduction of extracellular and cell-associated protease levels%2C as well as in the reduced levels of alpha-amylase%2C levansucrase%2C alkaline phosphatase and sporulation inhibition%2C when present in high copy number.%3B~High confidence in function and specificity gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_128 ZOBELLIA_1280 ZOBELLIA_1280 gntT2 gntT2 1532356 1533672 + High-affinity gluconate transporter GntT is part of the gluconate utilization system Gnt-I. It is a permease responsible for high-affinity intake of gluconate%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1280 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1280 ZOBELLIA_1281 ZOBELLIA_1281 ZOBELLIA_1281 1533688 1534443 + GDSL-like Lipase Conserved protein belonging to the GDSL Lipase family%2C which includes a variety of lipolytic enzymes with serine as part of the active site%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1281 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1281 ZOBELLIA_1282 ZOBELLIA_1282 ZOBELLIA_1282 1534505 1535158 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1282 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1282 ZOBELLIA_1283 ZOBELLIA_1283 ZOBELLIA_1283 1535161 1537341 - Glutaryl-7-aminocephalosporanic-acid acylase%2C family S45 Glutaryl-7-aminocephalosporanic-acid acylase%2C also known as cephalosporin acylase (CA)%2C hydrolyzes the (7R)-7-(4-carboxybutanamido)cephalosporanate to (7R)-7-aminocephalosporanate and glutarate. The form catalytically active of CA%2C an alpha-beta dimer%2C is obtained by two proteolytic cleavages%3B Belongs to the family S45 of the serine peptidases%3B Contains an uncleavable signal peptide%3B Localized into the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1283 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1283 ZOBELLIA_1284 ZOBELLIA_1284 ZOBELLIA_1284 1537387 1538430 - Conserved hypothetical membrane protein Conserved protein belonging to the DUF477 family%3B Contains three transmembrane helices in the C-terminal region%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1284 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1284 ZOBELLIA_1285 ZOBELLIA_1285 ZOBELLIA_1285 1538558 1540294 + ABC-1 type exporter%2C ATP-binding/permease protein The ABC-1 type transporters have their ABC membrane domain and their ABC ATPase domain fused in the same protein. They are involved in the efflux of compounds across the biological membranes or in targeting of membrane components%3B Contains six N-terminal transmembrane segments (ABC membrane) that form a pore in the cytoplasmic membrane an a C-terminal ATP-binding domain (ABC ATPase) responsible for energy generation%3B Belongs to the ABC-1 type transporter permease/ATP-binding family%2C lipid exporter subfamily (msbA subfamily)%3B~Family membership gene gene1285 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1285 ZOBELLIA_1286 ZOBELLIA_1286 fdxA1 fdxA1 1540291 1540620 - 2Fe-2S ferredoxin Ferredoxins are electron carrier proteins with an iron-sulfur as cofactor and that transfer electrons in a wide variety of metabolic reactions. Belongs to the putidaredoxin%2C terpredoxin and adrenodoxin sub-family and uses 2Fe-2S cluster as cofactor ligated at four conserved cysteine residues. The general core structure consists of beta(2)-alpha-beta(2). Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1286 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1286 ZOBELLIA_1287 ZOBELLIA_1287 ZOBELLIA_1287 1540672 1541016 - Conserved hypothetical protein Localized in the cytoplasm gene gene1287 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1287 ZOBELLIA_1288 ZOBELLIA_1288 trxB2 trxB2 1541066 1542124 - Thioredoxin reductase This Enzyme is a class-2 pyridine nucleotide-disulphide reductases (PNDR). The active site is a redox-active disulfide bond. It uses the FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step%2C the reduced disulphide reduces the substrate%3B Acts as an homodimer and binds one FAD molecule per subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1288 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1288 ZOBELLIA_1289 ZOBELLIA_1289 ZOBELLIA_1289 1542196 1542435 - NifU family protein Conserved protein displaying similarity with the C-terminal domain of the Nitrogen fixation protein nifU. This latter protein is involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. Localized in the cytoplasm.%3B~Family membership gene gene1289 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1289 ZOBELLIA_129 ZOBELLIA_129 ZOBELLIA_129 146512 147531 - NAD(P)-dependent sugar epimerase/dehydratase Conserved protein belonging to the NAD(P)-dependent sugar epimerase/dehydratase family%2C which is included in the Rossmann fold Superfamily. Localized in the cytoplasm.%3B~Specificity unclear gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_129 ZOBELLIA_1290 ZOBELLIA_1290 mrpA mrpA 1542437 1543576 - Protein mrp The exact function of the protein mrp is still unknown. But mrp is homologous to the P loop NTPase Nbp35 from Saccharomyces cerevisiae%2C which is involved in the assembly of Fe/S proteins%3B Localized in the cytoplasm%3B~Function unclear gene gene1290 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1290 ZOBELLIA_1291 ZOBELLIA_1291 atl1 atl1 1543833 1544177 - Alkyltransferase-like protein 1 Atl1 acts as a DNA damage recognition factor. It is required for DNA repair from mutagenic O(6)-alkylguanine adducts. Binds O(6)-alkylguanine lesions providing a signal for other DNA repair pathways. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1291 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1291 ZOBELLIA_1292 ZOBELLIA_1292 ZOBELLIA_1292 1544177 1544806 - Conserved hypothetical protein Protein that consists of a LysE type translocator domain with six transmembrane segments%3B Probably localized in the cytoplasmic memmbrane gene gene1292 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1292 ZOBELLIA_1293 ZOBELLIA_1293 trmB trmB 1544809 1545477 - tRNA (guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase is involved in tRNA maturation. It catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1293 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1293 ZOBELLIA_1294 ZOBELLIA_1294 ZOBELLIA_1294 1545488 1546564 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1294 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1294 ZOBELLIA_1295 ZOBELLIA_1295 ZOBELLIA_1295 1546702 1547388 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity (here%2C a winged-helix DNA-binding domain) that acts as transcriptional regulator%3B~Family membership gene gene1295 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1295 ZOBELLIA_1296 ZOBELLIA_1296 ZOBELLIA_1296 1547594 1549996 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 26 and 27%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1296 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1296 ZOBELLIA_1297 ZOBELLIA_1297 ZOBELLIA_1297 1550102 1552918 + TonB-dependent receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (22-102) and the Plug module (125-228) acting as a channel gate. The signal peptide is cleaved between the residues 19 and 20.%3B~Family membership gene gene1297 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1297 ZOBELLIA_1298 ZOBELLIA_1298 ZOBELLIA_1298 1553206 1553514 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1298 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1298 ZOBELLIA_1299 ZOBELLIA_1299 ZOBELLIA_1299 1553735 1554058 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1299 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1299 ZOBELLIA_13 ZOBELLIA_13 rplS rplS 11755 12105 + Ribosomal protein L19 Ribosomal protein L19 is a part of the small (50S) ribosomal subunit. The protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site%3B Belongs to the ribosomal protein L19p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_13 ZOBELLIA_130 ZOBELLIA_130 dpsA1 dpsA1 147750 148229 - DNA protection during starvation protein DspA protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions%2C which prevents hydroxyl radical production by the Fenton reaction%3B Forms a homododecamer and the 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_130 ZOBELLIA_1300 ZOBELLIA_1300 fkpB fkpB 1554157 1554588 - FKBP-type peptidyl-prolyl cis-trans isomerase 2 Peptidyl-prolyl cis-trans isomerase%2C or PPIase or rotamase%2C accelerates the folding of proteins. It catalyzes the peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation in oligopeptides%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1300 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1300 ZOBELLIA_1301 ZOBELLIA_1301 ZOBELLIA_1301 1554859 1555836 + Hypothetical protein Hypothetical protein that contains a N-terminal LuxE domain%3B Localized in the cytoplasm gene gene1301 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1301 ZOBELLIA_1302 ZOBELLIA_1302 ZOBELLIA_1302 1555833 1556363 - Conserved hypothetical protein Localized in the cytoplasm gene gene1302 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1302 ZOBELLIA_1303 ZOBELLIA_1303 tyrS tyrS 1556449 1557744 - Tyrosyl-tRNA synthetase Tyrosyl-tRNA synthetase catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Belongs to the class I of the aminoacyl-tRNA synthetases. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1303 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1303 ZOBELLIA_1304 ZOBELLIA_1304 ZOBELLIA_1304 1557849 1558856 + NAD-dependent epimerase/dehydratase family The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions and NAD as a cofactor%3B Belongs to the NAD-dependent epimerase/dehydratase family%2C Rossmann fold Superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1304 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1304 ZOBELLIA_1305 ZOBELLIA_1305 ZOBELLIA_1305 1558837 1559235 - Conserved hypothetical protein Localized in the cytoplasm gene gene1305 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1305 ZOBELLIA_1306 ZOBELLIA_1306 pucH pucH 1559261 1560595 - Allantoinase Allantoinase is involved in purine metabolism. It catalyzes the reaction: (S)-allantoin + H2O %3D allantoate. Binds one zinc ion. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1306 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1306 ZOBELLIA_1307 ZOBELLIA_1307 ppmA ppmA 1560597 1561325 - Polyprenol phosphate mannose synthase%2C family GT2 Polyprenol phosphate mannose synthase catalyses the transfer of mannose from GDP-mannose to polyprenol phosphate. Polyprenol phosphate mannose is a sugar donor%3B Belongs to the family 2 of the glycosyltransferases (GT2)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1307 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1307 ZOBELLIA_1308 ZOBELLIA_1308 ZOBELLIA_1308 1561488 1563155 + Glycosyltransferase%2C family GT83 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 83 of the glycosyltransferases. Displays also a C-terminal module of unknown function. Features nine N-terminal transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene1308 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1308 ZOBELLIA_1309 ZOBELLIA_1309 ZOBELLIA_1309 1563156 1563812 + Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1309 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1309 ZOBELLIA_131 ZOBELLIA_131 ZOBELLIA_131 148337 149275 + LysR-type transcriptional regulator Transcriptional regulator belonging to the LysR family. Features a N-terminal helix-turn-helix DNA binding domain and a C-terminal LysR-like substrate binding domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_131 ZOBELLIA_1310 ZOBELLIA_1310 hemD hemD 1563819 1564565 + Uroporphyrinogen-III synthase Uroporphyrinogen-III synthase is the fourth enzyme in the heme biosynthesis pathway. It catalyzes the reaction: hydroxymethylbilane %3D uroporphyrinogen III + H2O. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1310 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1310 ZOBELLIA_1311 ZOBELLIA_1311 pckA2 pckA2 1564648 1566246 - Phosphoenolpyruvate carboxykinase [ATP] Phosphoenolpyruvate carboxykinase (ATP) (PEPCK) catalyzes the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate while hydrolyzing ATP%2C a rate limiting step in gluconeogenesis. PEPCK is allosterically activated by calcium and positively regulated by cAMP. It is involved in the glyoxylate bypass%2C an alternative to the tricarboxylic acid cycle%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1311 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1311 ZOBELLIA_1312 ZOBELLIA_1312 ZOBELLIA_1312 1566332 1566718 - Conserved hypothetical membrane protein Protein containing a domain of unknown function DUF423 and Features four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1312 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1312 ZOBELLIA_1313 ZOBELLIA_1313 lys9 lys9 1566800 1568179 + Saccharopine dehydrogenase Saccharopine dehydrogenase is a homodimer that converts the N6-(L-1%2C3-dicarboxypropyl)-L-lysine to L-glutamate and L-2-aminoadipate 6-semialdehyde. Each subunit consists of three domains. Domain I contains a variant of the Rossmann fold that binds NADPH. Domain II%2C involved in substrate binding and dimer formation%2C folds into a mixed seven-stranded beta sheet flanked by alpha helices. Domain III is all-helical%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1313 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1313 ZOBELLIA_1314 ZOBELLIA_1314 asnC2 asnC2 1568275 1568745 + Transcriptional regulator AsnC The transcriptional regulator AsnC is the activator of the asnA gene involved in the asparagine synthesis and is a autogenous regulator of its own transcription%3B Contains a N-terminal AsnC/Lrp-type HTH domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1314 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1314 ZOBELLIA_1315 ZOBELLIA_1315 ZOBELLIA_1315 1568777 1569112 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1315 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1315 ZOBELLIA_1316 ZOBELLIA_1316 ftnA ftnA 1569220 1569732 + Ferritin Ferritin stores iron in a soluble%2C non-toxic%2C readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. It forms a homo-oligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1316 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1316 ZOBELLIA_1317 ZOBELLIA_1317 ZOBELLIA_1317 1569807 1570502 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1317 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1317 ZOBELLIA_1318 ZOBELLIA_1318 ZOBELLIA_1318 1570713 1570967 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1318 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1318 ZOBELLIA_1319 ZOBELLIA_1319 leuS leuS 1570995 1573931 - Leucyl-tRNA synthetase Leucyl-tRNA synthetase catalyses the attachment of leucine to its cognate transfer RNA molecule in a highly specific two-step reaction. Belongs to the class I of the aminoacyl-tRNA synthetases. It is a monomer and adopts a Rossmann fold. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1319 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1319 ZOBELLIA_132 ZOBELLIA_132 ZOBELLIA_132 149359 149544 - Conserved hypothetical protein Localized in the cytoplasm gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_132 ZOBELLIA_1320 ZOBELLIA_1320 ftsX ftsX 1574012 1574890 + Cell division protein FtsX Possible permease of unknown function essential for cell division. FtsX may function as part of a translocation apparatus that inserts proteins involved in cell division and proteins involved in gliding motility into the cytoplasmic membrane%3B Contains one N-terminal transmembrane segment and three C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1320 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1320 ZOBELLIA_1321 ZOBELLIA_1321 ZOBELLIA_1321 1574979 1575248 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1321 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1321 ZOBELLIA_1322 ZOBELLIA_1322 uppP uppP 1575250 1576044 + Undecaprenyl-diphosphatase Undecaprenyl-diphosphatase%2C as known as Bacitracin resistance protein%2C catalyzes the dephosphorylation of undecaprenyl diphosphate. Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate%2C thereby reducing the pool of lipid carrier available. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1322 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1322 ZOBELLIA_1323 ZOBELLIA_1323 truB truB 1576087 1576800 + tRNA pseudouridine synthase B TruB is responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. It catalyzes the reaction: tRNA uridine %3D tRNA pseudouridine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1323 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1323 ZOBELLIA_1324 ZOBELLIA_1324 ZOBELLIA_1324 1576870 1577601 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1324 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1324 ZOBELLIA_1325 ZOBELLIA_1325 ZOBELLIA_1325 1577578 1578204 - Conserved hypothetical protein Localized in the cytoplasm gene gene1325 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1325 ZOBELLIA_1326 ZOBELLIA_1326 tag tag 1578523 1579086 + DNA-3-methyladenine glycosylase DNA-3-methyladenine glycosylase catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions. The reaction releases a free base and leaves an apurinic site. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1326 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1326 ZOBELLIA_1327 ZOBELLIA_1327 ZOBELLIA_1327 1579120 1579710 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1327 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1327 ZOBELLIA_1328 ZOBELLIA_1328 ZOBELLIA_1328 1579691 1580377 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1328 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1328 ZOBELLIA_1329 ZOBELLIA_1329 aatA aatA 1580348 1581028 - Leucyl/phenylalanyl-tRNA--protein transferase Leucyl/phenylalanyl-tRNA--protein transferase transfers a Leu or Phe to the amino end of certain proteins to enable degradation. The N-terminal residue controls the biological half-life of many proteins via the N-end rule pathway.%3B~High confidence in function and specificity gene gene1329 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1329 ZOBELLIA_133 ZOBELLIA_133 dacB dacB 149679 150971 + D-alanyl-D-alanine carboxypeptidase%2C family S13 D-alanyl-D-alanine carboxypeptidase%2C also known as Penicillin-binding protein 4%2C is involved in the peptidoglycan biosynthesis. It hydrolyzes the D-Ala-D-Ala bond in the cross-linking peptide precursor%2C and performs the transpeptidation reaction between the D-Ala and the meso-2%2C6-diaminopimelate of adjacent crosslinking peptides of the bacterial cell wall%3B Belongs to the family S13 of the serine peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 27 and 28%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_133 ZOBELLIA_1330 ZOBELLIA_1330 ZOBELLIA_1330 1581136 1581513 - Conserved hypothetical protein Localized in the cytoplasm gene gene1330 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1330 ZOBELLIA_1331 ZOBELLIA_1331 ZOBELLIA_1331 1581615 1582280 - Conserved hypothetical membrane protein Contains a signal peptide cleaved between the residues 20 and 21%3B Could be localized in the outer membrane%3B~Conserved hypothetical protein gene gene1331 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1331 ZOBELLIA_1332 ZOBELLIA_1332 ZOBELLIA_1332 1582368 1583252 - Possible flavoredoxin The flavoredoxins are a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential producing reduced flavin for various biological processes%3B Some flavin reductases function in a two-component enzyme system%3B Contains a FMN-binding split barrel%3B~Specificity unclear gene gene1332 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1332 ZOBELLIA_1333 ZOBELLIA_1333 ZOBELLIA_1333 1583391 1584545 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1333 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1333 ZOBELLIA_1334 ZOBELLIA_1334 ZOBELLIA_1334 1584631 1584978 + Hypothetical membrane protein Contains a C-terminal transmembrane segment%3B Probably localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1334 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1334 ZOBELLIA_1335 ZOBELLIA_1335 ZOBELLIA_1335 1584975 1585367 - HIT family protein Conserved protein belonging to the Histidine Triad (HIT) family%2C which includes nucleotide-binding proteins%3B Localized in the cytoplasm%3B~Family membership gene gene1335 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1335 ZOBELLIA_1336 ZOBELLIA_1336 greA greA 1585382 1585858 - Transcription elongation factor GreA GreA is necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by GreA allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides%3B Belongs to the greA/greB family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1336 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1336 ZOBELLIA_1337 ZOBELLIA_1337 ZOBELLIA_1337 1586005 1586442 + Hypothetical lipoprotein Signal peptide of lipoprotein cleaved between the residues 15 and 16%3B localized in the outer membrane%3B~Hypothetical protein gene gene1337 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1337 ZOBELLIA_1338 ZOBELLIA_1338 ZOBELLIA_1338 1586448 1587131 - Conserved hypothetical protein Localized in the cytoplasm gene gene1338 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1338 ZOBELLIA_1339 ZOBELLIA_1339 ZOBELLIA_1339 1587164 1588141 - NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family. Adopts a Rossmann fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1339 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1339 ZOBELLIA_134 ZOBELLIA_134 ZOBELLIA_134 150995 151579 - Nucleoside diphosphate pyrophosphatase This family of proteins catalyses the hydrolysis of phosphorus-containing acid anhydrides such as nucleoside diphosphate%2C for example ADP-mannose and UDP-glucose%3B Protein that consists of a NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) domain%3B Localized in the cytoplasm%3B~Family membership gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_134 ZOBELLIA_1340 ZOBELLIA_1340 ZOBELLIA_1340 1588275 1590407 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Does not contain of carboxypeptidase regulatory domain%3B Contains the Plug module (44-155) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene1340 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1340 ZOBELLIA_1341 ZOBELLIA_1341 ZOBELLIA_1341 1590530 1590664 - Putative protein Hypothetical protein gene gene1341 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1341 ZOBELLIA_1342 ZOBELLIA_1342 ZOBELLIA_1342 1590796 1593276 + Two-component system hybrid-Sensor histidine kinase/Response regulator%2C receiver domain The sensor histidine kinase belongs to two-component signal transduction systems. The cytoplasmic part of the protein consists of the histidine kinase domain%2C the receiver domain of the response regulator that is phosphorylated by the histidine kinase domain and an histidine-containing Phosphotransfer (HPt) domain. A transmembrane segment separates this part from the periplasmic part that contains no particular domains%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1342 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1342 ZOBELLIA_1343 ZOBELLIA_1343 ZOBELLIA_1343 1593251 1594633 - Sigma-54 dependent two-component system-Response regulator These response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes%2C activating the expression of genes from promoters recognized by core RNA polymerase associated with the alternative sigma-54 factor. This protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C a motif that interacts with the sigma 54 factor and a C-terminal Fis-type HTH motif%3B~Family membership gene gene1343 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1343 ZOBELLIA_1344 ZOBELLIA_1344 ZOBELLIA_1344 1594812 1595117 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1344 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1344 ZOBELLIA_1345 ZOBELLIA_1345 ZOBELLIA_1345 1595191 1595496 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1345 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1345 ZOBELLIA_1346 ZOBELLIA_1346 ZOBELLIA_1346 1596002 1596307 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1346 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1346 ZOBELLIA_1347 ZOBELLIA_1347 ZOBELLIA_1347 1596640 1596948 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1347 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1347 ZOBELLIA_1348 ZOBELLIA_1348 ZOBELLIA_1348 1597183 1598721 - Conserved hypothetical protein Localized in the cytoplasm gene gene1348 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1348 ZOBELLIA_1349 ZOBELLIA_1349 ZOBELLIA_1349 1598718 1599191 - Conserved hypothetical protein Protein that displays similarity with the C-terminal region of the transcriptional regulator nadR%3B Localized in the cytoplasm gene gene1349 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1349 ZOBELLIA_135 ZOBELLIA_135 ZOBELLIA_135 151635 152054 - Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_135 ZOBELLIA_1350 ZOBELLIA_1350 pnuC1 pnuC1 1599239 1599877 - Nicotinamide mononucleotide transporter PnuC is a membrane protein responsible for nicotinamide mononucleotide transport%3B Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1350 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1350 ZOBELLIA_1351 ZOBELLIA_1351 ZOBELLIA_1351 1599861 1600121 - Conserved hypothetical protein Localized in the cytoplasm gene gene1351 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1351 ZOBELLIA_1352 ZOBELLIA_1352 ZOBELLIA_1352 1600223 1600855 - 4'-Phosphopantetheinyl transferase family protein Conserved protein belonging to the 4'-phosphopantetheinyl transferase family%3B The members of this family activates enzymes and carrier proteins%2C by transferring the phophopantethiene prosthetic group of coenzyme A to its attachment site (a serine residue). Many members of the family are small proteins that act on the acyl carrier protein involved in fatty acid biosynthesis%3B Uses magnesium ion as cofactor%3B Localized in the cytoplasm%3B~Family membership gene gene1352 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1352 ZOBELLIA_1353 ZOBELLIA_1353 ahcY ahcY 1600938 1602254 + Adenosylhomocysteinase Adenosylhomocysteinase is an enzyme of the activated methyl cycle%2C responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+ as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1353 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1353 ZOBELLIA_1354 ZOBELLIA_1354 phyC phyC 1602451 1603467 - 3-Phytase 3-Phytase%2C also known as myo-inositol-hexaphosphate 3-phosphohydrolase%2C catalyzes the hydrolysis of inorganic orthophosphate from phytate. It uses calcium ion as cofactor. Adopts a six- bladed beta propeller fold. Contains a prokaryotic lipoprotein signal peptide cleaved between 16 and 17%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene1354 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1354 ZOBELLIA_1355 ZOBELLIA_1355 ZOBELLIA_1355 1603526 1606390 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (28-107) and the Plug module (129-236) acting as a channel gate. The signal peptide is cleaved between the residues 25 and 26.%3B~Family membership gene gene1355 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1355 ZOBELLIA_1356 ZOBELLIA_1356 ZOBELLIA_1356 1606546 1607874 - TPR repeats protein Conserved protein containing five N-terminal tetratrico peptide repeats (TPRs)%2C a central transmembrane helix and a C-terminal domain of unknown function. TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1356 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1356 ZOBELLIA_1357 ZOBELLIA_1357 ZOBELLIA_1357 1607907 1608035 - Putative protein Hypothetical protein gene gene1357 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1357 ZOBELLIA_1358 ZOBELLIA_1358 rpmA rpmA 1608188 1608448 - Ribosomal protein L27 Ribosomal protein L27 is part of the large ribosomal subunit (50S). It cross-links to the 23S rRNA and to the A and P site tRNAs. RpmA is essential for ribosome function%2C but its exact role is unclear%3B Belongs to the ribosomal protein L27p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1358 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1358 ZOBELLIA_1359 ZOBELLIA_1359 rplU rplU 1608531 1609175 - Ribosomal protein L21 Ribosomal protein L21 is part of the large ribosomal subunit (50S). It binds to 23S rRNA in the presence of protein L20%3B Contains an domain C-terminal of 100 residues harbouring an Helix-hairpin-helix (HhH) motif involved in non-sequence-specific DNA binding. The function of this domain is unknown%3B Belongs to the ribosomal protein L21p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1359 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1359 ZOBELLIA_136 ZOBELLIA_136 ZOBELLIA_136 152152 152808 - Conserved hypothetical protein Protein localized in the cytoplasm gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_136 ZOBELLIA_1360 ZOBELLIA_1360 ZOBELLIA_1360 1609361 1609825 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1360 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1360 ZOBELLIA_1361 ZOBELLIA_1361 ZOBELLIA_1361 1609996 1611318 + Metallopeptidase%2C family M16 Peptidase family M16 contains metalloendopeptidases. Two of the zinc ligands occur in the motif His-Xaa-Xaa-Glu-His. The glutamate in this HXXEH motif is important for catalysis%2C and a glutamate more C- terminal is the third zinc ligand. Features a signal peptide cleaved between the residues 20 and 21. Localized in the periplasm.%3B~Specificity unclear gene gene1361 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1361 ZOBELLIA_1362 ZOBELLIA_1362 ZOBELLIA_1362 1611380 1613449 + Family M16 non-peptidase protein This protein belongs to the family 16 of the metallopeptidase%2C but the catalytic motif His-Xaa-Xaa-Glu-His (zinc-binding) is missing. This protein also displays a conserved C-terminal domain of unknown function. Features a signal peptide cleaved between the residues 19 and 20. Localized in the periplasm.%3B~Function unclear gene gene1362 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1362 ZOBELLIA_1363 ZOBELLIA_1363 irpA1 irpA1 1613610 1614725 - Iron-regulated protein A IrpA occurs under iron-deficient growth conditions and disappears in cells recovering from iron starvation. It seems to be involved in iron acquisition%2C uptake or storage%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 26 and 25%3B Localized in the cytoplasmic and/or outer membrane%3B~Function unclear gene gene1363 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1363 ZOBELLIA_1364 ZOBELLIA_1364 ZOBELLIA_1364 1614730 1616154 - Cytochrome c-containing protein Protein containing two Cytochrome c domains. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Contains a heme as prostetic group and a prokaryotic lipoprotein signal peptide cleaved between the residues 29 and 30%3B Localized in the outer membrane%3B~Function unclear gene gene1364 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1364 ZOBELLIA_1365 ZOBELLIA_1365 irpA2 irpA2 1616224 1617399 - Iron-regulated protein A IrpA occurs under iron-deficient growth conditions and disappears in cells recovering from iron starvation. It seems to be involved in iron acquisition%2C uptake or storage%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Function unclear gene gene1365 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1365 ZOBELLIA_1366 ZOBELLIA_1366 ZOBELLIA_1366 1617560 1618435 - Conserved hypothetical membrane protein Conserved membrane protein belonging to the DUF6 family%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1366 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1366 ZOBELLIA_1367 ZOBELLIA_1367 ZOBELLIA_1367 1618637 1619047 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1367 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1367 ZOBELLIA_1368 ZOBELLIA_1368 ZOBELLIA_1368 1619150 1619578 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1368 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1368 ZOBELLIA_1369 ZOBELLIA_1369 gldD gldD 1619610 1620164 - Gliding motility membrane lipoprotein Lipoprotein involved in the gliding motility%3B Signal peptide cleaved between the residues 17 and 18%3B localized in the cytoplasmic membrane%3B~Function unclear gene gene1369 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1369 ZOBELLIA_137 ZOBELLIA_137 ZOBELLIA_137 152874 153671 - Conserved hypothetical protein Protein that consists of a domain of unknown function (DUF124)%2C Localized in the cytoplasm gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_137 ZOBELLIA_1370 ZOBELLIA_1370 gldE gldE 1620151 1621470 - Gliding motility membrane protein GldE probably is a transporter%3B Contains four N-terminal transmembrane segments%2C followed of two CBS domains (Bateman domain) that have been shown to bind ligands with an adenosyl group such as AMP%2C ATP or S-AdoMet and may regulate the activity of attached enzymatic or other domains. Contains a C-terminal HlyC/CorC-type transporter associated domain%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1370 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1370 ZOBELLIA_1371 ZOBELLIA_1371 ssb1 ssb1 1621641 1622105 - Single-stranded DNA-binding protein Single-stranded DNA-binding protein (SSB) is essential for replication of the chromosome. It is also involved in DNA recombination and repair. This protein forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1371 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1371 ZOBELLIA_1372 ZOBELLIA_1372 mutY mutY 1622238 1623284 - A/G-specific adenine glycosylase MutY is an adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past go lesions which are due to the oxidatively damaged form of guanine: 7%2C8-dihydro-8-oxoguanine%3B 1 4Fe-4S cluster%2C not important for the catalytic activity%2C is present. This cluster is probably involved in the proper positioning of the enzyme along the DNA strand%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1372 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1372 ZOBELLIA_1373 ZOBELLIA_1373 ZOBELLIA_1373 1623297 1623428 - Putative protein Hypothetical protein gene gene1373 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1373 ZOBELLIA_1374 ZOBELLIA_1374 hupA hupA 1623464 1623754 + DNA-binding protein HU Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions. It forms a heterodimer of an alpha and a beta chain%3B Belongs to the bacterial histone-like protein family%3B localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1374 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1374 ZOBELLIA_1375 ZOBELLIA_1375 rngA rngA 1624053 1625600 + Ribonuclease G Ribonuclease G is involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure%3B Contains a S1 motif domain%3B Belongs to the RNase E/G family%2C RNase G subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1375 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1375 ZOBELLIA_1376 ZOBELLIA_1376 ZOBELLIA_1376 1625734 1626207 + RecX-type transcriptional regulator Transcriptional regulator belonging to the RecX family. Localized in the cytoplasm.%3B~Family membership gene gene1376 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1376 ZOBELLIA_1377 ZOBELLIA_1377 ZOBELLIA_1377 1626221 1626718 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1377 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1377 ZOBELLIA_1378 ZOBELLIA_1378 ZOBELLIA_1378 1626756 1627616 - Conserved hypothetical protein Localized in the cytoplasm gene gene1378 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1378 ZOBELLIA_1379 ZOBELLIA_1379 bioB bioB 1627693 1628787 - Biotin synthase Biotin synthase works with flavodoxin%2C S-adenosylmethionine%2C and possibly cysteine to catalyze the last step of the biotin biosynthetic pathway. The reaction consists of the introduction of a sulphur atom into dethiobiotin%2C thus requiring activation of C-H bonds. It forms a homodimer and binds one 4Fe-4S cluster by subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1379 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1379 ZOBELLIA_138 ZOBELLIA_138 ZOBELLIA_138 153746 154249 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_138 ZOBELLIA_1380 ZOBELLIA_1380 ZOBELLIA_1380 1628928 1630364 - Band 7 family protein Conserved protein belonging to the Band 7 family. The band 7 protein is an integral membrane protein which is thought to regulate cation conductance%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1380 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1380 ZOBELLIA_1381 ZOBELLIA_1381 ZOBELLIA_1381 1630369 1630947 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1381 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1381 ZOBELLIA_1382 ZOBELLIA_1382 fabB1 fabB1 1631020 1632207 - 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1382 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1382 ZOBELLIA_1383 ZOBELLIA_1383 bioA bioA 1632217 1633518 - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Enzyme that%2C in presence of S-adenosyl-L-methionine as donor%2C converts the 8-amino-7-oxononanoate to 7%2C8-diaminononanoate in the biotin anabolism%3B S-adenosylhomocysteine can also act as donor%3B Uses the Pyridoxal phosphate as cofactor linked to a conserved lysine residue%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1383 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1383 ZOBELLIA_1384 ZOBELLIA_1384 ZOBELLIA_1384 1633594 1635219 + Glycosyltransferase%2C family GT83 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 83 of the glycosyltransferases (GT83)%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1384 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1384 ZOBELLIA_1385 ZOBELLIA_1385 bioD bioD 1635226 1635843 - Dethiobiotin synthetase Dethiobiotin synthetase is involved in biotin biosynthesis and catalyzes the reaction: CO2 + 7%2C8-diaminononanoate + ATP %3D dethiobiotin + phosphate + ADP. The enzyme binds ATP and requires magnesium as a co-factor. It forms a homodimer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1385 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1385 ZOBELLIA_1386 ZOBELLIA_1386 ZOBELLIA_1386 1635845 1636228 - Conserved hypothetical protein Localized in the cytoplasm gene gene1386 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1386 ZOBELLIA_1387 ZOBELLIA_1387 bioF bioF 1636230 1637381 - 8-amino-7-oxononanoate synthase This enzyme catalyzes the 8-amino-7-oxononanoate formation used in the biotin biosynthesis. Uses the pyridoxal-phosphate as cofactor. Belongs to the class II of the pyridoxal-phosphate-dependent aminotransferases%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1387 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1387 ZOBELLIA_1388 ZOBELLIA_1388 ZOBELLIA_1388 1637525 1639336 + Metallopeptidase%2C family M61 This metallopeptidase encompasses a N-terminal catalytic domain belonging to the family M61 and a C-terminal PDZ domain. The active site residues are located in an HEXXH motif. The conserved Glu%2C 30 residues to the C-terminus of the HEXXH motif%2C likely is the third zinc ligand. PDZ domain bind either the carboxyl-terminal sequences of proteins or internal peptide sequences. Features a signal peptide cleaved between residues 18 and 19. localized in the periplasm.%3B~Specificity unclear gene gene1388 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1388 ZOBELLIA_1389 ZOBELLIA_1389 ZOBELLIA_1389 1639802 1640053 - Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1389 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1389 ZOBELLIA_139 ZOBELLIA_139 ZOBELLIA_139 154335 154814 + Conserved Hypothetical membrane protein Contains three transmembrane segments%3B Probably localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_139 ZOBELLIA_1390 ZOBELLIA_1390 ZOBELLIA_1390 1640144 1640353 + Putative membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1390 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1390 ZOBELLIA_1391 ZOBELLIA_1391 ZOBELLIA_1391 1640515 1640592 + Putative protein Hypothetical protein gene gene1391 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1391 ZOBELLIA_1392 ZOBELLIA_1392 ZOBELLIA_1392 1640592 1641110 + Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1392 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1392 ZOBELLIA_1393 ZOBELLIA_1393 ZOBELLIA_1393 1641113 1641535 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic and/or outer membrane%3B~Hypothetical protein gene gene1393 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1393 ZOBELLIA_1394 ZOBELLIA_1394 ZOBELLIA_1394 1642497 1642721 + Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1394 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1394 ZOBELLIA_1395 ZOBELLIA_1395 ZOBELLIA_1395 1642847 1643029 + Putative protein Hypothetical protein gene gene1395 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1395 ZOBELLIA_1396 ZOBELLIA_1396 ZOBELLIA_1396 1643126 1643368 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1396 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1396 ZOBELLIA_1397 ZOBELLIA_1397 ZOBELLIA_1397 1643365 1643649 + Putative exported protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1397 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1397 ZOBELLIA_1398 ZOBELLIA_1398 ZOBELLIA_1398 1643992 1646424 + Conserved hypothetical protein Localized in the cytoplasm gene gene1398 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1398 ZOBELLIA_1399 ZOBELLIA_1399 ZOBELLIA_1399 1646475 1651856 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1399 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1399 ZOBELLIA_14 ZOBELLIA_14 ZOBELLIA_14 12243 12467 - Putative protein Hypothetical protein gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_14 ZOBELLIA_140 ZOBELLIA_140 ZOBELLIA_140 154814 155266 + Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_140 ZOBELLIA_1400 ZOBELLIA_1400 ZOBELLIA_1400 1651838 1652146 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1400 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1400 ZOBELLIA_1401 ZOBELLIA_1401 ZOBELLIA_1401 1652468 1657480 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1401 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1401 ZOBELLIA_1402 ZOBELLIA_1402 ZOBELLIA_1402 1657584 1659545 + Fibronectin type-III repeats protein This conserved protein contains five type-III fibronectin (FN3) domains. Structures of individual FN3 domains have revealed a conserved beta sandwich fold with one beta sheet containing four strands and the other sheet containing three strands%3B Localized in the cytoplasm%3B~Family membership gene gene1402 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1402 ZOBELLIA_1403 ZOBELLIA_1403 ZOBELLIA_1403 1659550 1664535 + Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1403 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1403 ZOBELLIA_1404 ZOBELLIA_1404 atpC1 atpC1 1664745 1665023 - ATP synthase%2C F1 sector epsilon subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core%2C composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C and the F0 ATPase complex is the membrane-embedded proton channel%2C composed of at least 3 subunits (A-C). In the the F1 ATPase complex%2C the alpha and beta subunits form a cylinder that is attached to the central stalk composed of gamma%2C delta%2C epsilon subunits. The interaction site of subunit C of the F0 complex with the epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit).%3B~High confidence in function and specificity gene gene1404 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1404 ZOBELLIA_1405 ZOBELLIA_1405 atpD1 atpD1 1665093 1666601 - ATP synthase%2C F1 sector beta subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core%2C composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C and the F0 ATPase complex is the membrane-embedded proton channel%2C composed of at least 3 subunits (A-C). In the the F1 ATPase complex%2C the alpha and beta subunits form a cylinder that is attached to the central stalk composed of gamma%2C delta%2C epsilon subunits. There are three copies each of the alpha and beta subunits where a substrate-binding site%2C on each of these subunits is present%2C those on the beta subunits being catalytic%2C while those on the alpha subunits are regulatory. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP%2C which are induced by the rotation of the gamma subunit%2C itself is driven by the movement of protons through the F0 complex C subunit.%3B~High confidence in function and specificity gene gene1405 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1405 ZOBELLIA_1406 ZOBELLIA_1406 ZOBELLIA_1406 1666783 1668426 - Conserved hypothetical protein Localized in the cytoplasm gene gene1406 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1406 ZOBELLIA_1407 ZOBELLIA_1407 ZOBELLIA_1407 1668447 1671233 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a Plug module (112-223) acting as a channel gate. The signal peptide is cleaved between the residues 24 and 25%3B~Family membership gene gene1407 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1407 ZOBELLIA_1408 ZOBELLIA_1408 glmS glmS 1671433 1673280 - Glucosamine--fructose-6-phosphate aminotransferase Glucosamine--fructose-6-phosphate aminotransferase catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. It forms a homodimer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1408 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1408 ZOBELLIA_1409 ZOBELLIA_1409 ZOBELLIA_1409 1673468 1675303 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1409 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1409 ZOBELLIA_141 ZOBELLIA_141 ZOBELLIA_141 155410 155811 + PadR-type transcriptional regulator Transcriptional regulator belonging to the PadR family. Features a helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Specificity unclear gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_141 ZOBELLIA_1410 ZOBELLIA_1410 ZOBELLIA_1410 1675309 1676118 - Glycosyltransferase%2C family GT5 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 5 of the glycosyltransferases. This protein of about 270 residues is conserved within the Bacteroidetes phylum and displays high similarity with the N-terminal region of glycogen synthase. Its exact specificity is unknown. Localized in the cytoplasm.%3B~Specificity unclear gene gene1410 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1410 ZOBELLIA_1411 ZOBELLIA_1411 panC panC 1676223 1677065 + Pantoate-beta-alanine ligase Pantoate-beta-alanine ligase%2C also know as pantothenate synthase%2C catalyzes the formation of pantothenate from pantoate and alanine in the pantothenate biosynthesis pathway. PanC is a homodimer and binds one ATP by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1411 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1411 ZOBELLIA_1412 ZOBELLIA_1412 panD panD 1677083 1677433 + Aspartate 1-decarboxylase Aspartate 1-decarboxylase catalyzed the decarboxylation of aspartate%2C the major route of alanine production in bacteria. This enzyme is also involved in pantothenate biosynthesis. PanD requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. PanD forms a homotetramer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1412 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1412 ZOBELLIA_1413 ZOBELLIA_1413 ZOBELLIA_1413 1677436 1678401 + Conserved hypothetical membrane protein Conserved integral membrane protein belonging to the UPF0104 family%3B Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1413 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1413 ZOBELLIA_1414 ZOBELLIA_1414 ZOBELLIA_1414 1678429 1679571 + Esterase Esterase adopting an alpha/beta hydrolase fold. Its exact specificity is unknown%3B Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Specificity unclear gene gene1414 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1414 ZOBELLIA_1415 ZOBELLIA_1415 radA radA 1679641 1681002 + DNA repair protein May play a role in the repair of endogenous alkylation damage%3B Contains an N-terminal ATPase domain%3B Belongs to the recA family%2C RadA subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1415 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1415 ZOBELLIA_1416 ZOBELLIA_1416 tasA tasA 1681131 1682171 - Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene1416 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1416 ZOBELLIA_1417 ZOBELLIA_1417 xthA2 xthA2 1682302 1683069 - Exodeoxyribonuclease III The exonuclease III catalyses the cleavage in the 3'- to 5'-direction on double-stranded DNA to yield nucleoside 5'-phosphates. It also has an endonucleolytic activity near apurinic sites on DNA%3B Contains an Endonuclease/Exonuclease/phosphatase domains%3B Belongs to the DNA repair enzymes AP family 1%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1417 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1417 ZOBELLIA_1418 ZOBELLIA_1418 ZOBELLIA_1418 1683050 1683142 - Putative protein Hypothetical protein gene gene1418 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1418 ZOBELLIA_1419 ZOBELLIA_1419 ZOBELLIA_1419 1683156 1685237 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains the Plug module (43-152) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene1419 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1419 ZOBELLIA_142 ZOBELLIA_142 ZOBELLIA_142 155876 157717 + Hypothetical membrane protein Contains a PspC domain that is thought to be a stress-responsive transcriptional regulator%2C and four transmembrane segments%3B Probably localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_142 ZOBELLIA_1420 ZOBELLIA_1420 glyQS glyQS 1685234 1686784 - Glycyl-tRNA synthetase Glycyl-tRNA synthetase catalyzes the attachment of glycine to its cognate transfer RNA molecule in a highly specific two-step reaction. Belongs to the class II aminoacyl-tRNA synthetase family. It forms a homodimer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1420 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1420 ZOBELLIA_1421 ZOBELLIA_1421 ZOBELLIA_1421 1686822 1687718 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1421 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1421 ZOBELLIA_1422 ZOBELLIA_1422 ZOBELLIA_1422 1687776 1688483 + Phosphoribosyltransferase Phosphoribosyltransferase carries out phosphoryl transfer reactions on 5-phosphoribosyl-alpha1-pyrophosphate%2C an activated form of ribose-5-phosphate. Its exact specificity is still unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene1422 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1422 ZOBELLIA_1423 ZOBELLIA_1423 ZOBELLIA_1423 1688522 1690132 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1423 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1423 ZOBELLIA_1424 ZOBELLIA_1424 ZOBELLIA_1424 1690116 1690892 - Carbon-nitrogen hydrolase This enzyme belongs to a family containing hydrolases that break carbon-nitrogen bonds and appear to be involved in the reduction of organic nitrogen compounds and ammonia production. It features the E-K-C catalytic triad conserved in Nitrilase-related proteins%3B Adopts a alpha-beta-beta-alpha sandwich fold%3B Localized in the cytoplasm%3B~Family membership gene gene1424 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1424 ZOBELLIA_1425 ZOBELLIA_1425 nudF nudF 1690901 1691515 - ADP-ribose pyrophosphatase ADP-ribose pyrophosphatase catalyzes the Mg2+-dependent hydrolysis of ADP-ribose to ribose-5-phosphate and AMP%3B Belongs to the NUDIX hydrolase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1425 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1425 ZOBELLIA_1426 ZOBELLIA_1426 ZOBELLIA_1426 1691528 1692001 - Ankyrin repeats protein Conserved protein containing three ankyrin repeats. The ankyrin repeat is involved in protein-protein interaction. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure%3B Localized in the cytoplasm%3B~Function unclear gene gene1426 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1426 ZOBELLIA_1427 ZOBELLIA_1427 katA1 katA1 1692147 1693637 - Catalase This enzyme is a mono-functional haem-containing catalase that acts as an antioxidant enzyme catalyzing the conversion of hydrogen peroxide to water and molecular oxygen%2C serving to protect cells from its toxic effects. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1427 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1427 ZOBELLIA_1428 ZOBELLIA_1428 ZOBELLIA_1428 1693987 1696200 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains three N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Putatively localized in the cytoplasm%3B~Family membership gene gene1428 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1428 ZOBELLIA_1429 ZOBELLIA_1429 ZOBELLIA_1429 1696181 1696597 + Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene1429 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1429 ZOBELLIA_143 ZOBELLIA_143 ZOBELLIA_143 157839 158570 + Putative membrane lipoprotein Signal peptide cleaved between the residues 19 and 20%3B localized in the outer or cytoplasmic membrane or both%3B~Hypothetical protein gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_143 ZOBELLIA_1430 ZOBELLIA_1430 ZOBELLIA_1430 1696655 1697050 + Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene1430 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1430 ZOBELLIA_1431 ZOBELLIA_1431 ZOBELLIA_1431 1697057 1698436 - Putative membrane lipoprotein Lipoprotein that contains a C-terminal domain of 150 residues Signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1431 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1431 ZOBELLIA_1432 ZOBELLIA_1432 ZOBELLIA_1432 1698447 1701176 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-97) and the Plug module (107-214) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene1432 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1432 ZOBELLIA_1433 ZOBELLIA_1433 ZOBELLIA_1433 1701298 1702344 + Endonuclease/exonuclease/phosphatase family The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling%3B Belongs to the Endonuclease/Exonuclease/phosphatase family%3B Signal peptide cleaved between the residues 18 and 19%3B Probably localized in the periplasmic space%3B~Family membership gene gene1433 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1433 ZOBELLIA_1434 ZOBELLIA_1434 ZOBELLIA_1434 1702401 1703531 - Conserved hypothetical periplasmic protein Protein that contains nine MORN repeat variants including five repeats of twenty aminoacids%3B The MORN (membrane occupation and recognition nexus) repeats would contribute to the plasma membrane binding%2C possibly by interacting with phospholipids%3B Signal peptide cleaved between the residues 27 and 28%3B Probably localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1434 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1434 ZOBELLIA_1435 ZOBELLIA_1435 ZOBELLIA_1435 1703849 1704499 - Conserved hypothetical periplasmic protein Conserved protein belonging to the DUF1080 family%3B Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasm%3B~Conserved hypothetical protein gene gene1435 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1435 ZOBELLIA_1436 ZOBELLIA_1436 ZOBELLIA_1436 1704487 1704927 - Conserved hypothetical membrane protein Contains four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1436 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1436 ZOBELLIA_1437 ZOBELLIA_1437 ZOBELLIA_1437 1705019 1707574 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-97) and the Plug module (116-226) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene1437 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1437 ZOBELLIA_1438 ZOBELLIA_1438 pgiA pgiA 1707746 1709383 - Glucose-6-phosphate isomerase Glucose-6-phosphate isomerase is a dimeric enzyme that catalyses the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate in the second step of glycolysis (Embden-Meyerhof pathway) and in oxydative phase of pentose phosphate pathway. PgiA also is involved in the gluconeogenesis and in Pentose phosphate pathway%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1438 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1438 ZOBELLIA_1439 ZOBELLIA_1439 ZOBELLIA_1439 1709463 1710758 - Metallopeptidase%2C family M23 Endopeptidases that probably lyzes the bacterial cell wall peptidoglycan. One catalytic zinc ion is bound per peptidase molecule%3B Belongs to the M23 family of peptidases%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly loclaized in the outer membrane%3B~Specificity unclear gene gene1439 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1439 ZOBELLIA_144 ZOBELLIA_144 ZOBELLIA_144 158733 159746 + L-alanine-DL-glutamate epimerase L-alanine-DL-glutamate epimerase catalyzes the epimerization of D-Glu into L-Glu%2C in the context of the dipeptide L-Ala-D-Glu%2C which is a component of peptidoglycan. Involved in peptidoglycan metabolism. This enzyme belongs to the Mandelate racemase / muconate lactonizing enzyme family. These enzymes feature a N-terminal domain with a Enolase N-terminal domain-like fold and a C-terminal TIM alpha/beta barrel fold. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_144 ZOBELLIA_1440 ZOBELLIA_1440 tdoA2 tdoA2 1710760 1711731 - Tryptophan 2%2C3-dioxygenase Tryptophan 2%2C3-dioxygenase is Involved in L-kynurenine metabolism from L-tryptophan%2Cincorporating oxygen into the indole moiety of tryptophan. It has a broad specificity towards tryptamine and derivatives including D-and L-tryptophan%2C 5-hydroxytryptophan and serotonin%3B This enzyme forms a tetramer and binds 2 hemes per subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1440 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1440 ZOBELLIA_1441 ZOBELLIA_1441 ZOBELLIA_1441 1711737 1712516 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic%3B~Conserved hypothetical protein gene gene1441 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1441 ZOBELLIA_1442 ZOBELLIA_1442 hpdA hpdA 1713004 1714146 - 4-Hydroxyphenylpyruvate dioxygenase 4-hydroxyphenylpyruvate dioxygenase is involved in L_phenylalanine degradation. It oxidizes 4-hydroxyphenylpyruvate%2C a tyrosine and phenylalanine catabolite%2C to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. HpdA forms a homodimer and binds one iron ion by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1442 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1442 ZOBELLIA_1443 ZOBELLIA_1443 ZOBELLIA_1443 1714334 1716625 - Patatin-like phospholipase Conserved protein containing a N-terminal Patatin-like phospholipase domain and a C-terminal domain of unknown function%3B Contains a signal peptide cleaved between the residues 32 and 33%3B Localized in the periplasmic space%3B~Family membership gene gene1443 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1443 ZOBELLIA_1444 ZOBELLIA_1444 uvrC uvrC 1716609 1718396 - Excinuclease ABC%2C subunit C The UvrC protein belongs to the UvrABC repair system responsible of the recognition and processing of DNA lesions. UvrC catalyses the first incision on the fourth or fifth phosphodiester bond 3' and on the eighth phosphodiester bond 5' from the damage that is to be excised%3B The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision%3B Contains a C-terminal non-sequence-specific DNA binding HhH domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1444 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1444 ZOBELLIA_1445 ZOBELLIA_1445 MthfS MthfS 1718839 1719402 + 5-Formyltetrahydrofolate cyclo-ligase Methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclodehydrase) catalyzes the ATP-and Mg2+-dependent transformation of 5-formyltetrahydrofolate to 5%2C10-methenyltetrahydrofolate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1445 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1445 ZOBELLIA_1446 ZOBELLIA_1446 lspA lspA 1719406 1720047 - Signal peptidase II%2C family A8 The signal peptidase II specifically catalyzes the removal of signal peptides from prolipoproteins. Belongs to the family 8 of the aspartic peptidases. Two aspartate residues are essential for activity. They occur in the motifs GNXXDRX and FNXAD where X is a hydrophobic residue. Cleavage of the prelipoprotein occurs on the amino side of a modified cysteine residue%2C the thiol group of which is substituted with a diacylglyceryl group (an activity of phosphatidylglycerol:prolipoprotein diacylglyceryl transferase). The consensus around the cleavage site is known as the \\lipobox sequence\\ and is Leu-Xaa-YaaCys in which Xaa is Ala or Ser and Yaa is Gly or Ala. LpsA is membrane bound with four transmembrane domains.%3B~High confidence in function and specificity gene gene1446 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1446 ZOBELLIA_1447 ZOBELLIA_1447 ZOBELLIA_1447 1720085 1720765 - Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1447 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1447 ZOBELLIA_1448 ZOBELLIA_1448 ZOBELLIA_1448 1720770 1721153 - Zinc-finger protein Protein that belongs to the DksA family%2C which includes the DnaK suppressor protein (DksA)%3B Contains a 4-cysteine zinc finger in the C-terminal region%3B Localized in the cytoplasm%3B~Family membership gene gene1448 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1448 ZOBELLIA_1449 ZOBELLIA_1449 ileS ileS 1721158 1724556 - Isoleucyl-tRNA synthetase Isoleucyl-tRNA synthetase catalyzes the attachment of isoleucine to tRNA(Ile). As IleS can inadvertently accommodate and process structurally similar amino acids such as valine%2C to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). IleS has two distinct active sites: one for aminoacylation and one for editing. It binds one zinc ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1449 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1449 ZOBELLIA_145 ZOBELLIA_145 ZOBELLIA_145 159743 160786 + Aminotransferase%2C class II Aminotransferases are enzymes that catalysis the transfer of a nitrogenous group from one compound (donor) to another (acceptor) using pyridoxal-phosphate group%2C bound to a lysine residue%2C as cofactor%3B Localized in the cytoplasm%3B~Family membership gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_145 ZOBELLIA_1450 ZOBELLIA_1450 ZOBELLIA_1450 1724748 1725155 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1450 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1450 ZOBELLIA_1451 ZOBELLIA_1451 ZOBELLIA_1451 1725232 1727643 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-96) and the Plug module (111-219) acting as a channel gate%3B The signal peptide is cleaved between the residues 18 and 19%3B~Family membership gene gene1451 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1451 ZOBELLIA_1452 ZOBELLIA_1452 recO recO 1727645 1728364 - DNA repair protein RecO RecO may play a role in DNA repair. It seems to be involved in an recBC-independent recombinational process of DNA repair. It may act with recF and recR%3B RecO may adopt a mononucleotide-binding fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1452 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1452 ZOBELLIA_1453 ZOBELLIA_1453 gdhA1 gdhA1 1728493 1729836 - Glutamate dehydrogenase Glutamate dehydrogenase catalyzes the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate. It is involved with either ammonia assimilation or glutamate catabolism. Forms a homohexamer and binds one NAD(P) cofactor by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1453 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1453 ZOBELLIA_1454 ZOBELLIA_1454 metB metB 1729944 1731098 - Cystathionine gamma-synthase The Cystathionine gamma-synthase is found in the Selenoamino acid metabolism pathway and involved in the second step of the methionine biosynthesis%3B Uses a pyridoxal phosphate group as cofactor%2C attached to a lysine residue located in the central section of the enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1454 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1454 ZOBELLIA_1455 ZOBELLIA_1455 ZOBELLIA_1455 1731186 1731926 + Conserved hypothetical protein Localized in the cytoplasm gene gene1455 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1455 ZOBELLIA_1456 ZOBELLIA_1456 ZOBELLIA_1456 1731930 1732391 - Conserved hypothetical protein Localized in the cytoplasm gene gene1456 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1456 ZOBELLIA_1457 ZOBELLIA_1457 ZOBELLIA_1457 1732467 1732832 + ArsC family protein Conserved protein belonging to the Arsenate reductase (ArsC) family%3B Localized in the cytoplasm%3B~Family membership gene gene1457 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1457 ZOBELLIA_1458 ZOBELLIA_1458 ZOBELLIA_1458 1732829 1733731 + Conserved hypothetical membrane protein Integral membrane protein belonging to the DUF6 family%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1458 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1458 ZOBELLIA_1459 ZOBELLIA_1459 ZOBELLIA_1459 1733706 1734182 - Conserved hypothetical protein Localized in the cytoplasm gene gene1459 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1459 ZOBELLIA_146 ZOBELLIA_146 ZOBELLIA_146 160802 162280 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Probably localized in the outer membrane%3B~Family membership gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_146 ZOBELLIA_1460 ZOBELLIA_1460 ncd2 ncd2 1734305 1735279 + 2-Nitropropane dioxygenase 2-Nitropropane dioxygenase catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds. It acts on 2-nitropropane better than on nitroethane and 1-nitropropane%2C and anionic forms of nitroalkanes are much better substrates than are neutral forms. It forms a homodimer and uses FMN as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1460 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1460 ZOBELLIA_1461 ZOBELLIA_1461 ZOBELLIA_1461 1735335 1737008 - Cyclic nucleotide dependent thioredoxin reductase This protein consists of an N-terminal cyclic nucleotide binding domain and a C-terminal thioreductase domain%3B This Enzyme is a pyridine nucleotide-disulphide reductases (PNDR) where the active site is a redox-active disulfide bond. Acts as an homodimer%2C binds one FAD molecule per subunit and is regulated by the cyclic nucleotide binding (cAMP or cGMP)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1461 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1461 ZOBELLIA_1462 ZOBELLIA_1462 ZOBELLIA_1462 1737354 1738316 + Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene1462 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1462 ZOBELLIA_1463 ZOBELLIA_1463 ZOBELLIA_1463 1738392 1738877 + Cytochrome c Cytochromes c typically function in electron transfer. They are required during oxidative phosphorylation as an electron shuttle between Complex III (cytochrome c reductase) and IV (cytochrome c oxidase)%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Cytochrome c binds a heme as prosthetic group by Cys85 and Cys88. His89 is involved in iron binding%3B Belongs to class I (mono-heme) of Cytochrome c%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Probably localized in the cytoplasmic and/or outer membrane%3B~Function unclear gene gene1463 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1463 ZOBELLIA_1464 ZOBELLIA_1464 ZOBELLIA_1464 1738941 1740101 + Glycoside hydrolase%2C family GH105 This protein belongs to the family 105 of the glycoside hydrolases. These enzymes are involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. Asp175 is the putative catalytic residue (identical to Asp143 of the unsaturated rhamnogalacturonyl hydrolase from Bacillus subtilis%2C Itoh et al.%2C 2006%2C BBRC 347%2C 10211029). Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene1464 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1464 ZOBELLIA_1465 ZOBELLIA_1465 ZOBELLIA_1465 1740140 1741729 - Sulfate transporter Protein belonging to the sulfate transporter family. It may play a role in the regulation of sulfate assimilation%3B Contains a C-terminal STAS domain (Sulphate Transporter and AntiSigma factor antagonist)%2C which has been suggested to have a general NTP binding function%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1465 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1465 ZOBELLIA_1466 ZOBELLIA_1466 ZOBELLIA_1466 1741979 1742890 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene1466 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1466 ZOBELLIA_1467 ZOBELLIA_1467 gpsA gpsA 1743065 1744060 + Glycerol-3-phosphate dehydrogenase [NAD(P)+] NAD(P)-dependent glycerol-3-phosphate dehydrogenase is involved in phospholipid biosynthesis. It converts the sn-glycerol 3-phosphate to glycerone phosphate. It forms a homodimer%2C each monomer containing an N-terminal NAD binding domain and a C-terminal substrate-binding domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1467 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1467 ZOBELLIA_1468 ZOBELLIA_1468 glpD glpD 1744154 1745821 - Glycerol-3-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase is involved in glycerol catabolism. It converts the sn-glycerol 3-phosphate to glycerone phosphate%3B Uses FAD as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1468 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1468 ZOBELLIA_1469 ZOBELLIA_1469 glpK glpK 1745868 1747349 - Glycerol kinase Glycerol kinase is a key enzyme in the regulation of glycerol uptake and metabolism. It converts the glycerol to sn-glycerol 3-phosphate. It forms either a homotetramer or a homodimer (in equilibrium). Activity of this regulatory enzyme is affected by several metabolites%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1469 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1469 ZOBELLIA_147 ZOBELLIA_147 ZOBELLIA_147 162292 165447 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (20-93) and the Plug module (110-246) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_147 ZOBELLIA_1470 ZOBELLIA_1470 pbp1C pbp1C 1747452 1749797 - Penicillin-binding protein 1C%2C family GT51 Penicillin-binding protein 1C is a class A PBP involved in the synthesis of cross-linked peptidoglycan from the lipid II intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase central domain which may not be functional and a C-terminal domain of unknown function which is conserved in this sub-family of PBPs. The N-terminal domain belongs to the family 51 of the glycosyltransferases. Features an uncleaved signal peptide. Localized in the periplasm%2C anchored to the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1470 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1470 ZOBELLIA_1471 ZOBELLIA_1471 ZOBELLIA_1471 1749912 1750268 - Conserved hypothetical protein Localized in the cytoplasm gene gene1471 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1471 ZOBELLIA_1472 ZOBELLIA_1472 ZOBELLIA_1472 1750351 1750887 + CvpA family protein Conserved membrane protein distantly related to Colicin V production protein%3B Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1472 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1472 ZOBELLIA_1473 ZOBELLIA_1473 ZOBELLIA_1473 1750938 1751984 + Conserved hypothetical membrane protein Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1473 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1473 ZOBELLIA_1474 ZOBELLIA_1474 ZOBELLIA_1474 1752207 1752626 + Hypothetical membrane protein Contains a putattive lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene1474 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1474 ZOBELLIA_1475 ZOBELLIA_1475 ZOBELLIA_1475 1752705 1758218 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1475 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1475 ZOBELLIA_1476 ZOBELLIA_1476 ZOBELLIA_1476 1758563 1759039 + SCP-like extracellular protein SCP-like extracellular proteins have been proposed to be a calcium ion chelating serine proteases. The Calcium-chelating function would fit with the various signalling processes where members of this family are involved%2C and also the structural evidences of a conserved pocket containing two histidines and a glutamate%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Family membership gene gene1476 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1476 ZOBELLIA_1477 ZOBELLIA_1477 nbaC nbaC 1759182 1759721 + 3-Hydroxyanthranilate 3%2C4-dioxygenase 3-Hydroxyanthranilate 3%2C4-dioxygenase is involved in the 2-nitrobenzoate degradation pathway. It catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde%2C which spontaneously cyclizes to quinolinate. It forms a homodimer and binds 2 Fe(2+) ions per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1477 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1477 ZOBELLIA_1478 ZOBELLIA_1478 ZOBELLIA_1478 1759814 1761427 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain. Contains an uncleaved signal peptide and a N-terminal CHASE (Cyclases/Histidine kinases Associated Sensory Extracellular) domain. The CHASE domain is predicted to bind diverse low molecular weight ligands and mediate signal transduction through the respective receptors. It has a predicted alpha+beta fold%2C with two extended alpha helices on both boundaries and two central alpha helices separated by beta sheets. This protein is localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene1478 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1478 ZOBELLIA_1479 ZOBELLIA_1479 ZOBELLIA_1479 1761443 1761796 + Conserved hypothetical membrane protein Conserved protein belonging to the DUF1304 family%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1479 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1479 ZOBELLIA_148 ZOBELLIA_148 ZOBELLIA_148 165551 165703 + Putative protein Hypothetical protein gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_148 ZOBELLIA_1480 ZOBELLIA_1480 pcdA pcdA 1761931 1763484 + Piperideine-6-carboxylate dehydrogenase%2C aldehyde dehydrogenase family Piperideine-6-carboxylate dehydrogenase catalyses the conversion of Delta-1-Piperideine-6-carboxylate into alpha-aminoadipic acid. This latter compound is a precursor of cephamycin C antibiotic%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1480 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1480 ZOBELLIA_1481 ZOBELLIA_1481 ZOBELLIA_1481 1763615 1763929 - Hypothetical protein Putatively localized in the cytoplasm. gene gene1481 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1481 ZOBELLIA_1482 ZOBELLIA_1482 ZOBELLIA_1482 1764100 1765017 + OmpA-like membrane protein Protein that contains a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Contains a uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1482 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1482 ZOBELLIA_1483 ZOBELLIA_1483 ZOBELLIA_1483 1765041 1765604 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1483 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1483 ZOBELLIA_1484 ZOBELLIA_1484 ZOBELLIA_1484 1765619 1765747 - Putative protein Hypothetical protein gene gene1484 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1484 ZOBELLIA_1485 ZOBELLIA_1485 ACPD ACPD 1765963 1766961 - Acyl-[acyl-carrier-protein] desaturase Acyl-[acyl-carrier-protein] desaturase (or Stearoyl-ACP desaturase) converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons Delta(9) and Delta(10) of the acyl chain. It forms a homodimer. Involved in lipid metabolism. localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1485 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1485 ZOBELLIA_1486 ZOBELLIA_1486 ZOBELLIA_1486 1767027 1767752 - Serine/threonine-protein phosphatase Serine/threonine-protein phosphatase catalyzes the reaction: a phosphoprotein + H2O %3D a protein + phosphate. It binds one iron ion and one manganese ion. Belongs to the metallo-phosphoesterase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1486 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1486 ZOBELLIA_1487 ZOBELLIA_1487 ZOBELLIA_1487 1767749 1768831 - Conserved hypothetical membrane protein Contains a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1487 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1487 ZOBELLIA_1488 ZOBELLIA_1488 ZOBELLIA_1488 1768888 1770024 - Conserved hypothetical protein Localized in the cytoplasm gene gene1488 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1488 ZOBELLIA_1489 ZOBELLIA_1489 ZOBELLIA_1489 1770357 1773542 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (39-113) and the Plug module (129-236) acting as a channel gate%3B The signal peptide is cleaved between the residues 27 and 28%3B~Family membership gene gene1489 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1489 ZOBELLIA_149 ZOBELLIA_149 ZOBELLIA_149 165743 166162 + Conserved hypothetical protein Localized in the cytoplas gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_149 ZOBELLIA_1490 ZOBELLIA_1490 ZOBELLIA_1490 1773562 1775364 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Probably localized in the cytoplasmic membrane%3B~Family membership gene gene1490 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1490 ZOBELLIA_1491 ZOBELLIA_1491 scrK1 scrK1 1775549 1776496 + Fructokinase Fructokinase catalyzes the transfert of phosphate group from ATP to convert the fructose to fructose-6-phosphate%2C which is an entry point into glycolysis (Embden-Meyerhof pathway) via conversion into glucose-6-phosphate%3B Belongs to the carbohydrate kinase pfkB superfamily%2C bacterial fructokinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1491 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1491 ZOBELLIA_1492 ZOBELLIA_1492 ZOBELLIA_1492 1776501 1777637 - Conserved hypothetical protein Localized in the cytoplasm gene gene1492 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1492 ZOBELLIA_1493 ZOBELLIA_1493 ZOBELLIA_1493 1777634 1778389 - NADP-dependent L-serine/L-allo-threonine dehydrogenase Catalyzes the NADP-dependent oxidation of L-allo-threonine and L-serine%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1493 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1493 ZOBELLIA_1494 ZOBELLIA_1494 ZOBELLIA_1494 1778408 1779283 - Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene1494 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1494 ZOBELLIA_1495 ZOBELLIA_1495 ZOBELLIA_1495 1779442 1780443 + MoxR-like ATPase MoxR-like ATPases have been proposed to function with VWA domain proteins to form a chaperone system involved in the activation of proteins by primarily mediating the insertion of metal cofactors into the substrate molecules%3B Belongs to the MoxR-like family%3B Localized in the cytoplasm%3B~Function unclear gene gene1495 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1495 ZOBELLIA_1496 ZOBELLIA_1496 ZOBELLIA_1496 1780532 1781398 + vWA domain protein Conserved protein belonging to the von Willebrand factor type A (vWA) domain family. Some VWA domain proteins have been proposed to function with MoxR-like ATPases to form a chaperone system involved in the activation of proteins by primarily mediating the insertion of metal cofactors into the substrate molecules%3B Localized in the cytoplasm%3B~Family membership gene gene1496 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1496 ZOBELLIA_1497 ZOBELLIA_1497 ZOBELLIA_1497 1781398 1783062 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1497 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1497 ZOBELLIA_1498 ZOBELLIA_1498 batA batA 1783063 1784061 + Aerotolerance protein BatA The protein BatA is a membrane protein belonging to the Bat operon (Bacteroides aerotolerance). Its exact function is unknown. Contains two N-terminal a transmembrane helices%2C three von Willebrand factor type A domain and a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1498 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1498 ZOBELLIA_1499 ZOBELLIA_1499 batB batB 1784122 1785171 + Aerotolerance protein BatB The protein BatB is a membrane protein belonging to the Bat operon (Bacteroides aerotolerance). Its exact function is unknown%3B Contains two N-terminal a transmembrane helices%2C three von Willebrand factor type A domain and a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1499 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1499 ZOBELLIA_15 ZOBELLIA_15 icdA icdA 12820 15039 + Isocitrate dehydrogenase NADP-dependent%2C monomeric type NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism%2C as it controls the carbon flux within the citric acid cycle and supplies the cell to 2-oxoglutarate and NADPH for biosynthetic purposes%3B The activity of this enzyme%2C which is controlled by phosphorylation%2C helps regulate carbon flux between the Krebs cycle and the glyoxylate bypass%2C which is an alternate route that accumulates carbon for biosynthesis when acetate is the sole carbon source for growth%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_15 ZOBELLIA_150 ZOBELLIA_150 ZOBELLIA_150 166243 166689 + Conserved hypothetical membrane protein Contains an uncleaved signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_150 ZOBELLIA_1500 ZOBELLIA_1500 batC batC 1785172 1786029 + Aerotolerance protein BatC The protein BatC is a conserved protein belonging to the Bat operon (Bacteroides aerotolerance). Its exact function is unknown. Contains three N-terminal Tetratricopeptide repeats%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Function unclear gene gene1500 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1500 ZOBELLIA_1501 ZOBELLIA_1501 batD batD 1786068 1787807 + Aerotolerance protein BatD The protein BatD is a membrane protein belonging to the Bat operon (Bacteroides aerotolerance). Its exact function is unknown. Contains a C-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1501 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1501 ZOBELLIA_1502 ZOBELLIA_1502 batE batE 1787812 1788570 + Aerotolerance protein BatE The protein BatE is a membrane protein belonging to the Bat operon (Bacteroides aerotolerance). Its exact function is unknown%3B Contains two N-terminal Tetratricopeptide repeats%2C two central transmembrane helices and a C-terminal bacterial SH3 domain%3B Localized in the cytoplasmic membrane.%3B~Function unclear gene gene1502 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1502 ZOBELLIA_1503 ZOBELLIA_1503 ZOBELLIA_1503 1788630 1788926 + Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1503 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1503 ZOBELLIA_1504 ZOBELLIA_1504 ZOBELLIA_1504 1788996 1789367 + Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1504 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1504 ZOBELLIA_1505 ZOBELLIA_1505 canA1 canA1 1789644 1790240 + Carbonate dehydratase Carbonate dehydratase (or carbonic anhydrases) is a zinc metalloenzyme which catalyzes the reversible hydration of carbon dioxide. This enzyme is usually involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase. By this action%2C it prevents the depletion of cellular bicarbonate. Homodimer that binds one zinc ion by subunit%3B Belongs to the beta class of carbonic anhydrases%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1505 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1505 ZOBELLIA_1506 ZOBELLIA_1506 canA2 canA2 1790344 1790970 + Carbonate dehydratase Carbonate dehydratase (or carbonic anhydrases) is a zinc metalloenzyme which catalyzes the reversible hydration of carbon dioxide. This enzyme is usually involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase. By this action%2C it prevents the depletion of cellular bicarbonate. Homodimer that binds one zinc ion by subunit%3B Belongs to the beta class of carbonic anhydrases%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1506 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1506 ZOBELLIA_1507 ZOBELLIA_1507 ZOBELLIA_1507 1791062 1792942 + Sulfate transporter Protein belonging to the sulfate transporter family. Contains a C-terminal STAS domain (Sulphate Transporter and AntiSigma factor antagonist)%2C which has been suggested to have have a general NTP binding function%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1507 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1507 ZOBELLIA_1508 ZOBELLIA_1508 pheS pheS 1793021 1794040 + Phenylalanyl-tRNA synthetase alpha chain PheS encodes the alpha subunit of Phenylalanyl-tRNA synthetase. the Phenylalanyl-tRNA synthetase is an alpha2/beta2 tetramer that catalyzes the attachment of phenylalanine to its cognate transfer RNA molecule in a highly specific two-step reaction%3B Binds 2 magnesium ions per tetramer%3B Belongs to class II aminoacyl-tRNA synthetases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1508 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1508 ZOBELLIA_1509 ZOBELLIA_1509 ZOBELLIA_1509 1794051 1794446 + Conserved hypothetical protein Localized in the cytoplasm gene gene1509 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1509 ZOBELLIA_151 ZOBELLIA_151 trxB1 trxB1 166757 167722 - Thioredoxin reductase The active site of this enzyme is a redox-active disulfide bond. TrxB uses the FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step%2C the reduced disulphide reduces the substrate%3B Acts as an homodimer and binds one FAD molecule per subunit%3B Belongs to the class 2 of the pyridine nucleotide- disulphide reductases (PNDR)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_151 ZOBELLIA_1510 ZOBELLIA_1510 ZOBELLIA_1510 1794552 1795034 + Conserved hypothetical protein Localized in the cytoplasm gene gene1510 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1510 ZOBELLIA_1511 ZOBELLIA_1511 ZOBELLIA_1511 1795117 1796202 + Membrane fusion protein These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region%3B~Family membership gene gene1511 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1511 ZOBELLIA_1512 ZOBELLIA_1512 ZOBELLIA_1512 1796240 1799386 + Multidrug efflux transporter Integral membrane protein involved in drug resistance that belongs to the acrB/acrD/acrF family%3B Contains 12 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2%2C and helices 7 and 8. The three transmembrane domains form a large%2C 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1512 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1512 ZOBELLIA_1513 ZOBELLIA_1513 ZOBELLIA_1513 1799394 1800797 + Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Signal peptide of lipoprotein cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene1513 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1513 ZOBELLIA_1514 ZOBELLIA_1514 ZOBELLIA_1514 1800811 1801419 + TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene1514 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1514 ZOBELLIA_1515 ZOBELLIA_1515 ZOBELLIA_1515 1801422 1801889 - CYTH family protein Conserved protein belonging to the CYTH family%3B Localized in the cytoplasm%3B~Family membership gene gene1515 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1515 ZOBELLIA_1516 ZOBELLIA_1516 yraR yraR 1801882 1802556 - Protein yraR The protein yraR belongs to the NAD dependent epimerase/dehydratase family%2C but its exact function is unknown. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~Function unclear gene gene1516 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1516 ZOBELLIA_1517 ZOBELLIA_1517 dinB1 dinB1 1802585 1803685 + DNA polymerase IV The DNA polymerase IV is a poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. It copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis%2C in conjunction with the beta clamp from polIII%3B Induced by SOS response%3B Contains a umuC domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1517 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1517 ZOBELLIA_1518 ZOBELLIA_1518 ZOBELLIA_1518 1803917 1804738 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1518 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1518 ZOBELLIA_1519 ZOBELLIA_1519 ZOBELLIA_1519 1804814 1807288 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (21-93) and the Plug module (120-217) acting as a channel gate. The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene1519 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1519 ZOBELLIA_152 ZOBELLIA_152 ZOBELLIA_152 168043 168888 - Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains one N-terminal copy of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_152 ZOBELLIA_1520 ZOBELLIA_1520 ZOBELLIA_1520 1807352 1807756 - Conserved hypothetical protein Protein Localized in the cytoplasm gene gene1520 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1520 ZOBELLIA_1521 ZOBELLIA_1521 ZOBELLIA_1521 1807760 1808740 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B~Family membership gene gene1521 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1521 ZOBELLIA_1522 ZOBELLIA_1522 ZOBELLIA_1522 1808812 1810962 - Prolyl oligopeptidase%2C family S9 Prolyl oligopeptidase cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond%3B Belongs to the family S9 of the peptidases%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene1522 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1522 ZOBELLIA_1523 ZOBELLIA_1523 asdA asdA 1811061 1812050 - Aspartate-semialdehyde dehydrogenase Aspartate-semialdehyde dehydrogenase is a homodimer involved in the biosynthesis of various amino acids from aspartate (L-lysine%2C L-methionine and L-threonine. It converts the L-aspartate 4-semialdehyde into L-4-aspartyl phosphate%3B Contains a N-terminal NADP-binding domain (Rossmann fold) and a C-terminal dimerization domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1523 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1523 ZOBELLIA_1524 ZOBELLIA_1524 mscL mscL 1812257 1812661 - Large-conductance mechanosensitive channel The large-conductance mechanosensitive channel participates in the regulation of changes of osmotic pressure within the cell by openning%2C in response to stretch forces in the membrane lipid bilayer%2C at a pressure just below that which would cause cell disruption and death. It is a pentamer that forms a nonselective ion channel of 2.5 nanosiemens conductance%3B Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1524 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1524 ZOBELLIA_1525 ZOBELLIA_1525 alrA alrA 1812745 1813857 - Alanine racemase Alanine racemase plays a role in providing the D-alanine required for bacterial cell wall biosynthesis by isomerising L-alanine to D-alanine. Alanine racemase forms a homodimer%3B Uses the pyridoxal 5'-phosphate as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1525 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1525 ZOBELLIA_1526 ZOBELLIA_1526 tdkA tdkA 1813835 1814488 - Thymidine kinase Thymidine kinase is an ubiquitous enzyme that catalyzes the ATP-dependent phosphorylation of thymidine%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1526 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1526 ZOBELLIA_1527 ZOBELLIA_1527 ZOBELLIA_1527 1814660 1815370 + Conserved hypothetical protein Localized in the cytoplasm gene gene1527 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1527 ZOBELLIA_1528 ZOBELLIA_1528 ZOBELLIA_1528 1815488 1815844 + Conserved hypothetical membrane protein Contains four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1528 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1528 ZOBELLIA_1529 ZOBELLIA_1529 ZOBELLIA_1529 1815850 1816521 + Methyltransferases Enzyme that uses S-AdoMet in the methylation of diverse substrates%3B Belongs to the UPF0011 family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1529 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1529 ZOBELLIA_153 ZOBELLIA_153 ZOBELLIA_153 169150 169854 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity (here a LytTR-type HTH domain)%2C which acts as transcriptional regulator%3B~Family membership gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_153 ZOBELLIA_1530 ZOBELLIA_1530 ZOBELLIA_1530 1816527 1816871 + Conserved hypothetical protein Localized in the cytoplasm gene gene1530 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1530 ZOBELLIA_1531 ZOBELLIA_1531 ZOBELLIA_1531 1816877 1817455 + Conserved hypothetical protein Conserved hypothetical protein distantly related to the Uracil-DNA glycosylase superfamily%3B Localized in the cytoplasm gene gene1531 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1531 ZOBELLIA_1532 ZOBELLIA_1532 ZOBELLIA_1532 1817640 1818068 + Conserved hypothetical protein Protein Localized in the cytoplasm%3B~Family membership gene gene1532 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1532 ZOBELLIA_1533 ZOBELLIA_1533 ZOBELLIA_1533 1818143 1818499 + Conserved hypothetical protein Localized in the cytoplasm gene gene1533 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1533 ZOBELLIA_1534 ZOBELLIA_1534 recJ recJ 1818775 1820463 + Single-stranded-DNA-specific exonuclease RecJ RecJ is a 5'-3' single-strand DNA exonuclease. Required for many types of recombinational events%2C although the stringency of the requirement for recJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1534 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1534 ZOBELLIA_1535 ZOBELLIA_1535 ZOBELLIA_1535 1820460 1820846 + Glyoxalase superfamily protein Protein belonging to the Glyoxalase superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1535 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1535 ZOBELLIA_1536 ZOBELLIA_1536 ZOBELLIA_1536 1821178 1822437 + Major facilitator superfamily transporter The Major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. The specificity of this transporter is not known%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1536 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1536 ZOBELLIA_1537 ZOBELLIA_1537 ZOBELLIA_1537 1822427 1823200 - Metallophosphoesterase family Conserved protein belonging to the metallophosphoesterase family. The most conserved regions in this superfamily centre around the metal chelating residues. Distantly related to UDP-2%2C3-diacylglucosamine hydrolase (LpxH)%2C which is involved in lipid A biosynthesis%3B Localized in the cytoplasm%3B~Family membership gene gene1537 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1537 ZOBELLIA_1538 ZOBELLIA_1538 ptsA ptsA 1823240 1823692 - 6-Pyruvoyl tetrahydrobiopterin synthase 6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin%2C the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin is the cofactor for several aromatic amino acid monooxygenases. The enzyme is a homohexameric%2C composed of a dimer of trimers. A transition metal binding site formed by the three histidine residues is present in each subunit%2C and bound Zn(II) is responsible for the enzymatic activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1538 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1538 ZOBELLIA_1539 ZOBELLIA_1539 ZOBELLIA_1539 1823780 1824421 + Prolyl 4-hydroxylase Prolyl 4-hydroxylase is a dioxygenase%2C requiring 2-oxoglutarate%2C dioxygen as cosubstrates and ferrous iron as a cofactor. The iron ion is bound by three conserved residues (HxD and H). Prokaryotic enzymes might catalyze hydroxylation of antibiotic peptides%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1539 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1539 ZOBELLIA_154 ZOBELLIA_154 galK galK 169910 171040 - Galactokinase Involved in the first step of galactose metabolism that catalyzes the D-galactose to alpha-D-galactose-1-phosphate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene154 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_154 ZOBELLIA_1540 ZOBELLIA_1540 ZOBELLIA_1540 1824598 1825365 - Enoyl-CoA hydratase/isomerase family Enoyl-CoA hydratase (4.2.1.17) (ECH) and 3-2trans-enoyl-CoA isomerase (5.3.3.8) (ECI) are two enzymes involved in fatty acid metabolism.%3B~Family membership gene gene1540 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1540 ZOBELLIA_1541 ZOBELLIA_1541 ZOBELLIA_1541 1825405 1826739 - Multi antimicrobial extrusion protein family Contains 12 transmembrane segments%3B Belongs to the multi antimicrobial extrusion (MATE) family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1541 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1541 ZOBELLIA_1542 ZOBELLIA_1542 ZOBELLIA_1542 1826750 1827250 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene1542 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1542 ZOBELLIA_1543 ZOBELLIA_1543 ZOBELLIA_1543 1827302 1828102 + Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains one N-terminal copy of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene1543 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1543 ZOBELLIA_1545 ZOBELLIA_1545 ZOBELLIA_1545 1828750 1832643 + One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Probably localized in the cytoplasmic membrane%3B~Family membership gene gene1545 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1545 ZOBELLIA_1546 ZOBELLIA_1546 ZOBELLIA_1546 1832912 1833793 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B this protein contains a C- terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal GAF domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1546 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1546 ZOBELLIA_1547 ZOBELLIA_1547 ZOBELLIA_1547 1834010 1834618 + Conserved hypothetical lipoprotein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG)%3B Contains a prokaryotic lipoprotein signal peptide cleavage between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1547 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1547 ZOBELLIA_1548 ZOBELLIA_1548 ZOBELLIA_1548 1834763 1835386 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1548 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1548 ZOBELLIA_1549 ZOBELLIA_1549 ZOBELLIA_1549 1835694 1836896 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains a GAF domain%3B Possibly localized in the cytoplasmic membrane%3B~Family membership gene gene1549 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1549 ZOBELLIA_155 ZOBELLIA_155 fgeA fgeA 171047 172192 - C-alpha-formylglycine-generating protein Converts newly synthesized inactive sulfatases to their active form by modifying an active site cysteine or serine residue to 3-oxoalanine%3B Putatively localized in the outer membrane%3B~Specificity unclear gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_155 ZOBELLIA_1550 ZOBELLIA_1550 ZOBELLIA_1550 1837058 1837153 - Putative protein Hypothetical protein gene gene1550 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1550 ZOBELLIA_1551 ZOBELLIA_1551 ZOBELLIA_1551 1837214 1838485 - Exopolysaccharide production protein Conserved protein involved in exopolysaccharide biosynthesis. Its exact function is unknown. Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1551 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1551 ZOBELLIA_1552 ZOBELLIA_1552 ZOBELLIA_1552 1838675 1838905 - Putative protein Hypothetical protein gene gene1552 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1552 ZOBELLIA_1553 ZOBELLIA_1553 ZOBELLIA_1553 1839054 1840319 - Nucleobase cation symporter Permease belonging to the Nucleobase Cation Symporter-1 (NCS1) family%2C which includes transporters for purines%2C pyrimidines and allantoin. It functions in uptake by substrate:H+ symport mechanism%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1553 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1553 ZOBELLIA_1554 ZOBELLIA_1554 pepD1 pepD1 1840330 1841775 - Xaa-His dipeptidase%2C family M20 Xaa-His dipeptidase%2C also known as aminoacyl-histidine dipeptidase%2C catalyzes the hydrolysis of Xaa-|-His dipeptides. This dipeptidase has specificity for the unusual dipeptide beta-alanyl-L-histidine. PepD binds two co-catalytic zinc ions that activate the catalytic water molecule%3B Belongs to the family M20 of the metallopeptidase%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1554 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1554 ZOBELLIA_1555 ZOBELLIA_1555 ZOBELLIA_1555 1841775 1843043 - Nucleobase cation symporter Permease belonging to the Nucleobase Cation Symporter-1 (NCS1) family%2C which includes transporters for purines%2C pyrimidines and allantoin. It functions in uptake by substrate:H+ symport mechanism%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1555 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1555 ZOBELLIA_1556 ZOBELLIA_1556 ZOBELLIA_1556 1843043 1844095 - Non-peptidase protein%2C Family M29 This protein belongs to the family 29 of the metallopeptidases%2C but lacks some of the catalytic or metal-binding residues%3B Localized in the cytoplasm%3B~Function unclear gene gene1556 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1556 ZOBELLIA_1557 ZOBELLIA_1557 ZOBELLIA_1557 1844130 1846451 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (20-89) and the Plug module (117-223) acting as a channel gate%3B The signal peptide is cleaved between the residues 17 and 18%3B~Family membership gene gene1557 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1557 ZOBELLIA_1558 ZOBELLIA_1558 ZOBELLIA_1558 1846572 1847807 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1558 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1558 ZOBELLIA_1559 ZOBELLIA_1559 ZOBELLIA_1559 1847954 1849246 + Conserved hypothetical membrane protein Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1559 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1559 ZOBELLIA_156 ZOBELLIA_156 siaHI siaHI 172339 173679 - Exo-alpha-sialidase Exo-alpha-sialidase catalyzes the hydrolysis of alpha-(2->3)-%2C alpha-(2->6)-%2C alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides%2C glycoproteins%2C glycolipids%2C colominic acid and synthetic substrates. Features a twin-arginine signal peptide. Localized in the periplasm.%3B~High confidence in function and specificity gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_156 ZOBELLIA_1560 ZOBELLIA_1560 ZOBELLIA_1560 1849243 1850412 + FAD-dependent oxidoreductase Conserved oxidoreductase using FAD as cofactor. Contains two structural domains%2C a N-terminal beta/beta/alpha sandwich domain and a C-terminal alpha+beta fold domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene1560 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1560 ZOBELLIA_1561 ZOBELLIA_1561 ZOBELLIA_1561 1850405 1851082 + Haloacid dehalogenase-like hydrolase Conserved hydrolase belonging to the haloacid dehalogenase family%2C which includes L-2-haloacid dehalogenase%2C epoxide hydrolases and phosphatases. The structure consists of two domains%2C a four helix bundle domain and a alpha/beta domain. Localized in the cytoplasm.%3B~Family membership gene gene1561 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1561 ZOBELLIA_1562 ZOBELLIA_1562 ZOBELLIA_1562 1851174 1851740 - Xre-type transcriptional regulator Transcriptional regulator featuring a N-terminal helix-turn-helix DNA binding motif belonging to the Xre family and a C-terminal domain adopting a Cupin barrel fold. Localized in the cytoplasm.%3B~Specificity unclear gene gene1562 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1562 ZOBELLIA_1563 ZOBELLIA_1563 ZOBELLIA_1563 1852014 1855232 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (22-96) and the Plug module (112-241) acting as a channel gate%3B The signal peptide is cleaved between the residues 17 and 18%3B~Family membership gene gene1563 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1563 ZOBELLIA_1564 ZOBELLIA_1564 ZOBELLIA_1564 1855262 1856707 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane%3B~Family membership gene gene1564 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1564 ZOBELLIA_1565 ZOBELLIA_1565 ZOBELLIA_1565 1856790 1858436 + Type I phosphodiesterase Protein containing a N-terminal Type I phosphodiesterase domain and a C-terminal PA14 domain. These enzymes catalyze the cleavage of phosphodiester and phosphosulphate bonds in various compounds such as NAD%2C deoxynucleotides and nucleotide sugars. The PA14 domain sequence suggests a binding function%2C rather than a catalytic role and its distribution is compatible with carbohydrate binding%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasm%3B~Family membership gene gene1565 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1565 ZOBELLIA_1566 ZOBELLIA_1566 ZOBELLIA_1566 1858437 1859708 + Metallohydrolase Protein belonging to the Metallo-beta-lactamase superfamily. This superfamily includes various zinc-dependent hydrolases. The residues involved in metal ion binding are strictly conserved in this protein%3B Localized in the cytoplasm%3B~Family membership gene gene1566 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1566 ZOBELLIA_1567 ZOBELLIA_1567 ZOBELLIA_1567 1859695 1861053 + Aminotransferase class-III Aminotransferases share certain mechanistic features with other pyridoxalphosphate-dependent enzymes%2C such as the covalent binding of the pyridoxalphosphate group to a lysine residue%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene1567 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1567 ZOBELLIA_1568 ZOBELLIA_1568 ZOBELLIA_1568 1861067 1862662 + Metallophosphoesterase Protein containing a N-terminal Fibronectin type III domain%2C a central metallophosphoesterase domain and a second Fibronectin type III domain at the C-terminus. The most conserved regions in the metallophosphoesterase family centre around the metal chelating residues%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Family membership gene gene1568 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1568 ZOBELLIA_1569 ZOBELLIA_1569 ZOBELLIA_1569 1862659 1863741 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasm%3B~Conserved hypothetical protein gene gene1569 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1569 ZOBELLIA_157 ZOBELLIA_157 ZOBELLIA_157 174180 175430 + Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_157 ZOBELLIA_1570 ZOBELLIA_1570 ZOBELLIA_1570 1864001 1864108 + Putative protein Hypothetical protein gene gene1570 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1570 ZOBELLIA_1571 ZOBELLIA_1571 ZOBELLIA_1571 1864123 1864986 + Metallophosphoesterase Conserved protein belonging to the metallophosphoesterase family. The most conserved regions in this superfamily centre around the metal chelating residues%3B Localized in the cytoplasm%3B~Family membership gene gene1571 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1571 ZOBELLIA_1572 ZOBELLIA_1572 ZOBELLIA_1572 1865009 1866022 + Glycosyltransferase%2C family GT1 The Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 1 of the glycosyltransferases (GT1)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1572 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1572 ZOBELLIA_1573 ZOBELLIA_1573 bglA bglA 1866023 1867438 + Beta-glucosidase%2C family GH1 Beta-glucosidases catalyze the hydrolysis of terminal%2C non-reducing beta-D-glucose residues with release of beta-D-glucose%3B Belongs to the family 1 of the glycoside hydrolases (GH1) and adopts a (beta/alpha)8 barrel fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1573 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1573 ZOBELLIA_1574 ZOBELLIA_1574 ZOBELLIA_1574 1867655 1868950 - TRAP transporter%2C large permease subunit This protein is the large permease component of a tripartite ATP-independent periplasmic (TRAP) transport system that comprises an extracytoplasmic solute receptor protein and two transmembrane proteins. TRAP transporters are secondary carriers that use an electrochemical H+ gradient as the driving force for transport%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1574 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1574 ZOBELLIA_1575 ZOBELLIA_1575 ZOBELLIA_1575 1868956 1869414 - TRAP transporter%2C small permease subunit This protein is the small permease component of a tripartite ATP-independent periplasmic (TRAP) transport system that comprises an extracytoplasmic solute receptor protein and two transmembrane proteins. TRAP transporters are secondary carriers that use an electrochemical H+ gradient as the driving force for transport%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1575 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1575 ZOBELLIA_1576 ZOBELLIA_1576 ZOBELLIA_1576 1869416 1870396 - TRAP transporter%2C substrate-binding periplasmic subunit This protein is the substrate-binding periplasmic subunit component of a tripartite ATP-independent periplasmic (TRAP) transport system that comprises an extracytoplasmic solute receptor protein and two transmembrane proteins. TRAP transporters are secondary carriers that use an electrochemical H+ gradient as the driving force for transport%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Specificity unclear gene gene1576 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1576 ZOBELLIA_1577 ZOBELLIA_1577 uxaC uxaC 1870408 1871862 - Uronate isomerase Uronate isomerase catalyzes the reaction D-glucuronate to D-fructuronate and also converts D-galacturonate to D-tagaturonate. It is involved in the pentose and glucuronate interconversion. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1577 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1577 ZOBELLIA_1578 ZOBELLIA_1578 ZOBELLIA_1578 1872116 1872826 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene1578 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1578 ZOBELLIA_1579 ZOBELLIA_1579 ZOBELLIA_1579 1872848 1875604 - Conserved hypothetical protein Localized in the cytoplasm gene gene1579 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1579 ZOBELLIA_158 ZOBELLIA_158 ZOBELLIA_158 175877 178912 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (26-100) and the Plug module (116-221) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~Family membership gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_158 ZOBELLIA_1580 ZOBELLIA_1580 ZOBELLIA_1580 1875668 1877026 - OmpA-like periplasmic protein This protein contains a N-terminal domain of unknown function followed by five Thrombospondin type 3 repeats and a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space and/or in outer membrane%3B~Family membership gene gene1580 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1580 ZOBELLIA_1581 ZOBELLIA_1581 kblA2 kblA2 1877140 1878333 - Glycine C-acetyltransferase Enzyme involved in the Glycine%2C serine and threonine metabolism%2C and in particular%2C in the glycine catabolism%3B Also called 2-amino-3-ketobutyrate coenzyme A ligase%3B Uses the Pyridoxal phosphate as cofactor%3B Belongs to the class II of the pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1581 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1581 ZOBELLIA_1582 ZOBELLIA_1582 recB recB 1878345 1881497 - Exodeoxyribonuclease V%2C beta chain The Exonuclease V is a multifunctional nuclease required for efficient DNA repair. It catalyzes the unwinding of double-stranded DNA and the cleavage of single-stranded DNA and it stimulates local genetic recombination. All of these activities require concomitant hydrolysis of ATP%3B Belongs to the helicase family%2C UvrD subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1582 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1582 ZOBELLIA_1583 ZOBELLIA_1583 sodA sodA 1881571 1882179 + Superoxide dismutase [Mn] Manganese superoxide dismutase destroys radicals which are normally produced within the cells and which are toxic to biological systems. It catalyzes the reaction: superoxide + 2 H+ %3D O2 + H2O2. SodA features an alpha N-terminal domain and an alpha/beta C-terminal domain%2C connected by a loop. It forms a homodimer and binds one manganese ion by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1583 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1583 ZOBELLIA_1584 ZOBELLIA_1584 ZOBELLIA_1584 1882805 1883104 + Putative protein Hypothetical protein gene gene1584 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1584 ZOBELLIA_1585 ZOBELLIA_1585 purF purF 1883379 1885277 - Amidophosphoribosyltransferase Amidophosphoribosyltransferase catalyzes the first step in purine biosynthesis: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate %3D L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PurF belongs to the Class-II glutamine amidotransferase family. It forms a homotetramer and binds one magnesium ion per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1585 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1585 ZOBELLIA_1586 ZOBELLIA_1586 ZOBELLIA_1586 1885323 1886249 - Carbohydrate kinase Kinases that accept a wide variety of substrates%2C including carbohydrates and aromatic small molecules%2C all are phosphorylated at a hydroxyl group%3B Belongs to the Carbohydrate kinase PfkB family%2C Ribokinase subfamily%2C group C%3B Localized in the cytoplasm%3B~Family membership gene gene1586 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1586 ZOBELLIA_1587 ZOBELLIA_1587 ZOBELLIA_1587 1886313 1886432 - Putative protein Hypothetical protein gene gene1587 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1587 ZOBELLIA_1588 ZOBELLIA_1588 rnhA rnhA 1886465 1887100 - Ribonuclease H Ribonuclease H (RNase H) is a non-specific endoribonuclease that cleaves the 3'-O-P-bond of RNA strands in RNA/DNA hybrids. In DNA replication of prokaryotes%2C It helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus. It cleaves the RNA primer to produce a 3OH extremity and to allow initiation of the replication by DNA PolIII. It also could be involved in processing of R loops to modulate replication initiation and restore DNA topology %3B Contains a RNA/DNA hybrid binding domain (RHBD) N-terminal to the catalytic domain that belongs to the ribosomal protein L9 family%3B Binds 2 metal ions (manganese or magnesium)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1588 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1588 ZOBELLIA_1589 ZOBELLIA_1589 purN purN 1887100 1887669 - Phosphoribosylglycinamide formyltransferase Phosphoribosylglycinamide formyltransferase catalyzes the third step in de novo purine biosynthesis%2C the transfer of a formyl group to 5'-phosphoribosylglycinamide. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1589 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1589 ZOBELLIA_159 ZOBELLIA_159 ZOBELLIA_159 178924 180411 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Family membership gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_159 ZOBELLIA_1590 ZOBELLIA_1590 acpP1 acpP1 1887830 1888063 + Acyl carrier protein Acyl carrier protein (ACP) is the carrier of the growing fatty acid chain in fatty acid biosynthesis. ACP is produced as an apoprotein and is converted to its active form by [ACP]synthase (AcpS)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1590 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1590 ZOBELLIA_1591 ZOBELLIA_1591 fabB2 fabB2 1888176 1889429 + 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1591 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1591 ZOBELLIA_1592 ZOBELLIA_1592 rncA rncA 1889436 1890173 + Ribonuclease III Ribonuclease III is an endoribonuclease that cleaves double-stranded RNA molecules to 5'- phosphomonoester. RNase III is involved in both rRNA processing and mRNA processing and decay%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1592 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1592 ZOBELLIA_1593 ZOBELLIA_1593 ZOBELLIA_1593 1890283 1890747 + Conserved hypothetical protein Localized in the cytoplasm gene gene1593 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1593 ZOBELLIA_1594 ZOBELLIA_1594 pykA pykA 1890751 1892181 + Pyruvate kinase Pyruvate kinase (PK) catalyzes the final step in glycolysis (Embden-Meyerhof pathway)%2C the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP. PK forms a homotetramer and requires both magnesium and potassium ions for its activity. PK helps control the rate of glycolysis%2C along with phosphofructokinase and hexokinase. PK possesses allosteric sites for numerous effectors%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1594 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1594 ZOBELLIA_1595 ZOBELLIA_1595 ZOBELLIA_1595 1892214 1892723 - PAS fold sensor protein Protein adopting a PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. PAS fold proteins are known to detect their signal by way of an associated cofactor (Haeme%2C flavin or 4-hydroxycinnamyl chromophore)%3B Localized in the cytoplasm.%3B~Function unclear gene gene1595 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1595 ZOBELLIA_1596 ZOBELLIA_1596 ZOBELLIA_1596 1892884 1893732 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1596 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1596 ZOBELLIA_1597 ZOBELLIA_1597 ZOBELLIA_1597 1893824 1893976 + Putative protein Hypothetical protein gene gene1597 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1597 ZOBELLIA_1598 ZOBELLIA_1598 ZOBELLIA_1598 1894053 1894601 + Carboxymuconolactone decarboxylase family protein Protein belonging to the carboxymuconolactone decarboxylase family. Its exact function is unknown%3B Localized in the cytoplasm%3B~Family membership gene gene1598 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1598 ZOBELLIA_1599 ZOBELLIA_1599 ZOBELLIA_1599 1894715 1895104 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1599 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1599 ZOBELLIA_16 ZOBELLIA_16 ZOBELLIA_16 15163 17562 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-102) and the Plug module (119-226) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_16 ZOBELLIA_160 ZOBELLIA_160 ZOBELLIA_160 180535 183843 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins%3B The FG-GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B The FG-GAP repeat has been predicted to fold into a beta propeller structure%3B Contain a uncleavable signal peptide that Would localizes the protein in the cytoplasmic membrane%3B~Function unclear gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_160 ZOBELLIA_1600 ZOBELLIA_1600 ZOBELLIA_1600 1895126 1895266 - Putative protein Hypothetical protein gene gene1600 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1600 ZOBELLIA_1601 ZOBELLIA_1601 ZOBELLIA_1601 1895544 1896002 + Putative small multi-drug export protein This protein belongs to a family of putative small multi-drug export proteins%3B Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1601 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1601 ZOBELLIA_1602 ZOBELLIA_1602 ZOBELLIA_1602 1896026 1896475 - Conserved hypothetical protein Localized in the cytoplasm gene gene1602 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1602 ZOBELLIA_1603 ZOBELLIA_1603 ilvD2 ilvD2 1896481 1898202 - Dihydroxy-acid dehydratase Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine%2C the dehydratation of 2%2C3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid%3B Binds a 4Fe-4S cluster%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1603 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1603 ZOBELLIA_1604 ZOBELLIA_1604 ZOBELLIA_1604 1898329 1899444 - FAD-dependent oxidoreductase FAD-dependent oxidoreductase of unknown substrate specificity%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1604 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1604 ZOBELLIA_1605 ZOBELLIA_1605 ZOBELLIA_1605 1899554 1901113 + Hypothetical lipoprotein Hypothetical protein display three N-terminal Fibronectin type-III domains (FN3) and a C-terminal domain of unknown function. FN3 domains adopt a conserved beta sandwich fold also found in bacterial glycosyde hydrolases and other proteins%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 28 and 29%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1605 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1605 ZOBELLIA_1606 ZOBELLIA_1606 accC accC 1901178 1902530 - Acetyl-coenzyme A carboxylase%2C biotin carboxylase subunit The biotin carboxylase is a part of the Acetyl-coenzyme A carboxylase complex that catalyzes the first step in long-chain fatty acid biosynthesis. the complex is a heterohexamer of biotin carboxyl carrier protein (accB)%2C biotin carboxylase and two subunits each of carboxyl transferase subunit alpha (accA) and subunit beta (accD). First%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1606 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1606 ZOBELLIA_1607 ZOBELLIA_1607 accB accB 1902616 1903107 - Acetyl-coenzyme A carboxylase%2C biotin carboxyl carrier protein subunit The biotin carboxyl carrier protein is a part of the Acetyl-coenzyme A carboxylase complex that catalyzes the first step in long-chain fatty acid biosynthesis. the complex is a heterohexamer of biotin carboxyl carrier protein%2C biotin carboxylase (accC) and two subunits each of carboxyl transferase subunit alpha (accA) and subunit beta (accD). First%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1607 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1607 ZOBELLIA_1608 ZOBELLIA_1608 fabH2 fabH2 1903142 1904134 - 3-oxoacyl-[acyl-carrier-protein] synthase III 3-oxoacyl-[acyl-carrier-protein] synthase III%2C also known as beta-ketoacyl-ACP synthase III%2C catalyses the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain. Negatively regulated by acyl-ACP%2C possibly by binding to either the free enzyme or the acyl-enzyme intermediate%3B Localzed in the cytoplasm%3B~High confidence in function and specificity gene gene1608 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1608 ZOBELLIA_1609 ZOBELLIA_1609 ZOBELLIA_1609 1904147 1904242 + Putative protein Hypothetical protein gene gene1609 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1609 ZOBELLIA_161 ZOBELLIA_161 ZOBELLIA_161 183830 183925 - Putative protein Hypothetical protein gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_161 ZOBELLIA_1610 ZOBELLIA_1610 rpmF rpmF 1904314 1904511 - Ribosomal protein L32 The ribosomal protein L32 is part of the large subunit (50S) of the ribosome%3B Belongs to the ribosomal protein L32p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1610 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1610 ZOBELLIA_1611 ZOBELLIA_1611 ZOBELLIA_1611 1904519 1905043 - Conserved hypothetical protein Conserved protein belonging to the family DUF177%3B Localized in the cytoplasm%3B~Family membership gene gene1611 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1611 ZOBELLIA_1612 ZOBELLIA_1612 pdxA pdxA 1905204 1906250 - 4-Hydroxythreonine-4-phosphate dehydrogenase 4-Hydroxythreonine-4-phosphate dehydrogenase is involved in the biosynthesis of pyridoxal phosphate. It catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate. PdxA is a dimer and binds 1 divalent metal cation per subunit. Can use ions such as zinc%2C magnesium or cobalt. The active site is located at the dimer interface. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1612 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1612 ZOBELLIA_1613 ZOBELLIA_1613 ribE ribE 1906310 1906906 + Riboflavin synthase alpha chain Riboflavin synthase is an oligomer that consist of 3 alpha subunits and 60 beta subunits. It is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2%2C4(1H%2C3H)- pyrimidinedione and L-3%2C4-dihydrohy-2-butanone-4-phosphate via 6%2C7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6%2C7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2%2C4(1H%2C3H)- pyrimidinedione. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1613 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1613 ZOBELLIA_1614 ZOBELLIA_1614 ZOBELLIA_1614 1906908 1910708 - Conserved hypothetical periplasmic protein Contains two central TPR motifs and a C-terminal transglutaminase-like domain%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1614 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1614 ZOBELLIA_1615 ZOBELLIA_1615 ZOBELLIA_1615 1910934 1911350 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1615 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1615 ZOBELLIA_1616 ZOBELLIA_1616 ZOBELLIA_1616 1911378 1913189 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1616 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1616 ZOBELLIA_1617 ZOBELLIA_1617 ZOBELLIA_1617 1913273 1914028 + Conserved hypothetical membrane protein Conserved integral membrane protein belonging to the DUF81 family%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1617 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1617 ZOBELLIA_1618 ZOBELLIA_1618 ZOBELLIA_1618 1913991 1914236 - Putative protein Hypothetical protein gene gene1618 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1618 ZOBELLIA_1619 ZOBELLIA_1619 ZOBELLIA_1619 1914361 1916925 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1619 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1619 ZOBELLIA_162 ZOBELLIA_162 xylB xylB 183900 184916 - Beta-xylosidase%2C family GH43 Enzyme that hydrolyzes the beta-1%2C4-D-xylans linkage%2C to remove successive D-xylose residues from the non-reducing termini%3B Belongs to the family 43 of the glycoside hydrolase (GH43)%3B Protein localized in the cytoplasm%3B~High confidence in function and specificity gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_162 ZOBELLIA_1620 ZOBELLIA_1620 ZOBELLIA_1620 1916930 1917991 - Muconate cycloisomerase This enzyme is involved in the catabolism of aromatic (or chloroaromatic) compounds%2C derived from lignin%2C catechol or protocatechuate. Converts the 2%2C5-dihydro-5-oxofuran-2-acetate to cis%2Ccis-hexadienedioate%3B Contains a N-terminal Enolase domain-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase / muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1620 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1620 ZOBELLIA_1621 ZOBELLIA_1621 ZOBELLIA_1621 1917988 1919061 - Conserved hypothetical protein Conserved protein belonging to the DUF1611 family%3B Localized in the cytoplasm%3B~Family membership gene gene1621 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1621 ZOBELLIA_1622 ZOBELLIA_1622 thrC thrC 1919072 1920133 - Threonine synthase The threonine synthase catalyzes the transformation of homoserine-phosphate into threonine%3B Uses the pyridoxal phosphate as cofactor (vitamin B6) attached to a conserved lysine residue%3B Belongs to the serine/threonine dehydratase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1622 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1622 ZOBELLIA_1623 ZOBELLIA_1623 ZOBELLIA_1623 1920226 1921266 - Conserved hypothetical membrane protein Protein featuring five Kelch repeats. Kelch is a 50-residue motif%2C which forms a beta sheet. Several of these sheets associate to form a beta propeller structure%3B Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1623 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1623 ZOBELLIA_1624 ZOBELLIA_1624 ZOBELLIA_1624 1921305 1922744 - Rubredoxin family protein Conserved protein containing a C-terminal Rubredoxin-like domain. The most conserved feature of the rubredoxin-like domain is the cluster of four cysteines involved in iron binding (Cys-x-x-Cys-x(n)-Cys-x-x-Cys). This domain folds into a short three-stranded antiparallel beta-sheet and a number of loops%3B Localized in the cytoplasm%3B~Family membership gene gene1624 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1624 ZOBELLIA_1625 ZOBELLIA_1625 narB/nirB narB/nirB 1922757 1926287 - Respiratory nitrate/nitrite reductase Bifunctional enzyme involved in the denitrification processes (nitrate respiration). It contains in its N-terminal part a nitrate reductase module required for nitrate assimilation (reducing nitrate to nitrite) using molybdopterin and 1 4Fe-4S cluster as cofactors and in its C-terminal part a nitrite reductase module required for nitrite assimilation (reducing nitrite to ammonia) using FAD%2C 4Fe-4S cluster and siroheme as cofactors%3B Belongs to Belongs to the prokaryotic molybdopterin-containing oxidoreductase family and to the nitrite and sulfite reductase 4Fe-4S domain family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1625 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1625 ZOBELLIA_1626 ZOBELLIA_1626 ZOBELLIA_1626 1926431 1927774 - Cyclomaltodextrinase%2C family GH13 Cyclomaltodextrinase hydrolyzes cyclodextrins. Can also act on linear maltodextrins%2C with the exception of maltose. Belongs to the family GH13 of the glycoside hydrolases. Involved in starch/glycogen metabolism.%3B~High confidence in function and specificity gene gene1626 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1626 ZOBELLIA_1627 ZOBELLIA_1627 ZOBELLIA_1627 1927813 1928541 - Two-component system-Response regulator Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA- binding activity (here a LuxR-type HTH domain) that acts as transcriptional regulator%3B~Family membership gene gene1627 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1627 ZOBELLIA_1628 ZOBELLIA_1628 ZOBELLIA_1628 1928637 1929941 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1628 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1628 ZOBELLIA_1629 ZOBELLIA_1629 nrtC nrtC 1929977 1930801 - Nitrate-specific ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B Probably part of a high-affinity binding-protein-dependent transport system for nitrate. Probably responsible for energy coupling to the transport system%3B~Family membership gene gene1629 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1629 ZOBELLIA_163 ZOBELLIA_163 xylP xylP 184943 186400 - Sugar transport protein These integral membrane proteins mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters)%3B Belongs to the sodium:galactoside symporter family%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_163 ZOBELLIA_1630 ZOBELLIA_1630 nrtD nrtD 1930816 1931655 - Nitrate-specific ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B Probably part of a high-affinity binding-protein-dependent transport system for nitrate. Probably responsible for energy coupling to the transport system%3B~Family membership gene gene1630 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1630 ZOBELLIA_1631 ZOBELLIA_1631 nrtB nrtB 1931677 1932777 - Nitrate-specific BPD transport%2C permease component Probably part of a high-affinity binding-protein-dependent (BPD) transport system for nitrate%3B probably responsible for the translocation of the substrate across the membrane%3B Localized in the cytoplasmic membrane by six transmembrane segments%3B~High confidence in function and specificity gene gene1631 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1631 ZOBELLIA_1632 ZOBELLIA_1632 nrtA nrtA 1932817 1934202 - Nitrate-specific BPD transport protein%2C substrate-binding component Essential component of the nitrate-transporting system. May be the substrate-binding protein%3B Lipoprotein putatively anchored in the outer membrane or in the cytoplasmic membrane (or in both membranes) by its N-terminal lipidic residue (peripheral membrane protein)%3B~High confidence in function and specificity gene gene1632 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1632 ZOBELLIA_1633 ZOBELLIA_1633 ZOBELLIA_1633 1934452 1935207 - cAMP-binding dependent transcriptionnal regulator This protein complexes with cAMP via an N-terminal cyclic nucleotide-binding domain and binds to specific DNA sites%2C via a C-terminal crp-type HTH domain%2C near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA%3B~Family membership gene gene1633 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1633 ZOBELLIA_1634 ZOBELLIA_1634 ZOBELLIA_1634 1935222 1936634 - Nitrate/nitrite-specific MFS transporter protein Putatively involved in the uptake of nitrate or extrusion of nitrite%3B The proteins contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1634 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1634 ZOBELLIA_1635 ZOBELLIA_1635 cobA2 cobA2 1936910 1937725 - Uroporphyrin-III C-methyltransferase This enzyme catalyzes two sequential methylation reactions%2C forming precorrin-1 and precorrin-2 by methylations at C-2 and C-7 of uroporphyrinogen III respectively%3B It is the first enzyme specific to the cobalamin (vitamin B12) pathway and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12%2C siroheme and coenzyme F430%3B Belongs to the precorrin methyltransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1635 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1635 ZOBELLIA_1636 ZOBELLIA_1636 nirB nirB 1937808 1940324 + Nitrite reductase%2C large subunit Nitrite reductase%2C required for nitrite assimilation (reducing nitrite to ammonia)%2C catalyzes the second step of nitrate assimilation (denitrification)%3B Binds 1 siroheme and 1 2Fe-2S cluster%2C uses FAD as cofactor%3B It is an homodimer which associates with nirD%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1636 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1636 ZOBELLIA_1637 ZOBELLIA_1637 nirD nirD 1940402 1940779 + Nitrite reductase%2C small subunit Protein that consists of a Rieske domain%3B The rieske domain has a 2Fe-2S centre%3B Associates with NirB and is required for activity reductase of NirB%3B~High confidence in function and specificity gene gene1637 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1637 ZOBELLIA_1638 ZOBELLIA_1638 ZOBELLIA_1638 1940891 1941484 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene1638 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1638 ZOBELLIA_1639 ZOBELLIA_1639 ZOBELLIA_1639 1941515 1943368 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments and an N-terminal PAS/PAC domain involved in many signalling proteins where they are used as a signal sensor domain%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1639 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1639 ZOBELLIA_164 ZOBELLIA_164 xylA xylA 186407 187546 - Endo-beta-1%2C4-xylanase%2C family GH10 Enzyme that endohydrolyzes the beta-1%2C4-D-xylosidic linkages in xylans%3B Belongs to the family 10 of glycoside hydrolase (GH10)%3B The signal peptide is cleaved between the residues 17 and 18%3B This sequence is a lipoporotein putatively localized in the outer membrane%3B~High confidence in function and specificity gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_164 ZOBELLIA_1640 ZOBELLIA_1640 sirC sirC 1943355 1943939 + Precorrin-2 dehydrogenase This protein Catalyzes the dehydrogenation of precorrin-2 into siroheme that is the second step of the siroheme biosynthesis%3B This reaction consists of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin used as precursor in siroheme biosynthesis%3B Putatively also catalized the third step that is the conversion of sirohydrochlorin into siroheme%3B~High confidence in function and specificity gene gene1640 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1640 ZOBELLIA_1641 ZOBELLIA_1641 ZOBELLIA_1641 1943961 1944416 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1641 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1641 ZOBELLIA_1642 ZOBELLIA_1642 ZOBELLIA_1642 1944534 1945547 - Flavoprotein%2C bacterial luciferase family This protein is higly%3B~Family membership gene gene1642 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1642 ZOBELLIA_1643 ZOBELLIA_1643 ZOBELLIA_1643 1945712 1946734 - LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene1643 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1643 ZOBELLIA_1644 ZOBELLIA_1644 ZOBELLIA_1644 1946840 1946965 - Putative protein Hypothetical protein gene gene1644 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1644 ZOBELLIA_1645 ZOBELLIA_1645 ZOBELLIA_1645 1947126 1947545 - Conserved hypothetical protein Localized in the cytoplasm gene gene1645 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1645 ZOBELLIA_1646 ZOBELLIA_1646 ZOBELLIA_1646 1947646 1947918 + Putative protein Hypothetical protein gene gene1646 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1646 ZOBELLIA_1647 ZOBELLIA_1647 ZOBELLIA_1647 1947901 1948623 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1647 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1647 ZOBELLIA_1648 ZOBELLIA_1648 ZOBELLIA_1648 1948921 1949031 - Putative protein Hypothetical protein gene gene1648 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1648 ZOBELLIA_1649 ZOBELLIA_1649 ZOBELLIA_1649 1949035 1949151 + Putative protein Hypothetical protein gene gene1649 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1649 ZOBELLIA_165 ZOBELLIA_165 ZOBELLIA_165 187844 188323 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_165 ZOBELLIA_1650 ZOBELLIA_1650 ZOBELLIA_1650 1949157 1949492 + ArsR-type transcriptional regulator This transcription regulatory protein binds DNA via a helix-turn-helix (HTH) motif. The ArsR family includes several proteins that appear to dissociate from DNA in the presence of metal ions. Metal ion binding would induce a conformational change that would prevent the protein from binding DNA. This protein adopts a fold of five alpha-helices and a pair of antiparallel beta-strands. Most ArsR-like metalloregulators form homodimers. Localized in the cytoplasm.%3B~Specificity unclear gene gene1650 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1650 ZOBELLIA_1651 ZOBELLIA_1651 ZOBELLIA_1651 1949576 1950583 + Permease This family of integral membrane proteins are predicted to be permeases of unknown specificity (DUF318 family)%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1651 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1651 ZOBELLIA_1652 ZOBELLIA_1652 ZOBELLIA_1652 1950723 1950935 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1652 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1652 ZOBELLIA_1653 ZOBELLIA_1653 ZOBELLIA_1653 1951166 1951654 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1653 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1653 ZOBELLIA_1654 ZOBELLIA_1654 HsdR2 HsdR2 1951717 1954716 - Type I restriction enzyme ZgaDII%2C R subunit The type I restriction enzyme%2C Subunit R recognize specific short DNA sequences and cleaves at sites remote (1000 to 5000 bp) from the recognition sequence to give random double-stranded fragments with terminal 5'-phosphates. It is required for both endonuclease and ATPase activities%2C but not for modification%3B The Type I restriction and modification enzymes are complex%2C multifunctional systems composed of three polypeptides R%2C M and S and which require ATP%2C S-adenosyl methionine and magnesium as cofactors. In addition to their endonucleolytic and methylase activities%2C they are potent DNA-dependent ATPases%3B The sequence recognized by ZgaDII is unknown%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1654 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1654 ZOBELLIA_1655 ZOBELLIA_1655 hsdS2 hsdS2 1954713 1955984 - Type I restriction enzyme ZgaDII%2C S subunit The Type I restriction enzyme S subunit dictates DNA sequences specificity%3B Contains two DNA recognition domains%2C each specifying recognition of one of the two defined components of the bipartite DNA target sequence%3B The type I restriction enzyme%2C M and S subunits together form a N-6 adenine methyltransferase (MTase) that methylates the amino group at the C-6 position of a adenine residue in a hemimethylated DNA recognition sequence%2C in order to prevent the host from digesting its own genome via its restriction enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1655 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1655 ZOBELLIA_1656 ZOBELLIA_1656 ZOBELLIA_1656 1956120 1957775 - Possible transcriptional regulator This protein could be a transcriptional regulator containing an N-terminal HTH domain involved in the DNA binding%3B Contain a N-terminal AAA domain involved in the ATP binding%3B Localized in the cytoplasm%3B~Family membership gene gene1656 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1656 ZOBELLIA_1657 ZOBELLIA_1657 HsdM2 HsdM2 1957856 1959457 - Type I restriction enzyme ZgaDII%2C M subunit The type I restriction enzyme%2C M and S subunits together form a N-6 adenine methyltransferase (MTase) that methylates the amino group at the C-6 position of a adenine residue in a hemimethylated bipartite DNA recognition sequence%2C in order to prevent the host from digesting its own genome via its restriction enzyme. It acts as a maintenance MTase modifying the DNA so that both strands become methylated. If the recognition sequence is unmethylated%2C in the presence of the R subunit%2C the complex can also act as an endonuclease%2C binding to the same target sequence but cutting the DNA some distance from this site%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1657 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1657 ZOBELLIA_1658 ZOBELLIA_1658 ZOBELLIA_1658 1959502 1959600 - Putative protein Hypothetical protein gene gene1658 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1658 ZOBELLIA_1659 ZOBELLIA_1659 ZOBELLIA_1659 1959666 1959881 + Putative protein Hypothetical protein gene gene1659 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1659 ZOBELLIA_166 ZOBELLIA_166 ZOBELLIA_166 188472 188573 + Putative protein Hypothetical protein gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_166 ZOBELLIA_1660 ZOBELLIA_1660 ZOBELLIA_1660 1960073 1960297 - Conserved hypothetical protein Conserved hypothetical protein belonging to the UPF0156 family%3B Localized in the cytoplasm%3B~Family membership gene gene1660 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1660 ZOBELLIA_1662 ZOBELLIA_1662 ZOBELLIA_1662 1960594 1960998 - Glyoxalase superfamily protein Protein that belongs to the Glyoxalase superfamily protein Localized in the cytoplasm%3B~Family membership gene gene1662 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1662 ZOBELLIA_1663 ZOBELLIA_1663 rbfA rbfA 1961070 1961462 + Ribosome-binding factor A Ribosome-binding factor A associates with free 30S ribosomal subunits%2C but not with 30S subunits associates with the 50S subunits in the 70S ribosomes or polysomes. It essential for efficient processing of 16S rRNA and may interact with the 5'-terminal helix region of 16S rRNA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1663 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1663 ZOBELLIA_1664 ZOBELLIA_1664 ZOBELLIA_1664 1961465 1962658 + Conserved hypothetical membrane protein Protein distantly related to LolC%2C an permease involved in the ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1664 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1664 ZOBELLIA_1665 ZOBELLIA_1665 dusB dusB 1962670 1963665 - tRNA-dihydrouridine synthase B tRNA-dihydrouridine synthase B catalyzes the reduction of the 5%2C6-double bond of a uridine residue%2C resulting in the formation of dihydrouridine. This modified base is found in the D-loop of most tRNAs%3B Uses FAD as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1665 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1665 ZOBELLIA_1666 ZOBELLIA_1666 lgtA lgtA 1963733 1964500 + Prolipoprotein diacylglyceryl transferase Prolipoprotein diacylglyceryl transferase catalyzes the first step in lipoprotein biogenesis. It transfers the n-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins%3B Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1666 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1666 ZOBELLIA_1667 ZOBELLIA_1667 ZOBELLIA_1667 1964472 1965866 + Radical SAM family protein This protein belongs to the radical SAM family. These enzymes catalyze diverse reactions%2C including unusual methylations%2C isomerization%2C sulphur insertion%2C ring formation%2C anaerobic oxidation and protein radical formation. They generate a radical species by reductive cleavage of S-adenosylmethionine (SAM) through an unusual Fe-S center%3B Localized in the cytoplasm%3B~Family membership gene gene1667 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1667 ZOBELLIA_1668 ZOBELLIA_1668 ZOBELLIA_1668 1965884 1966048 + Conserved hypothetical membrane protein Contains one C-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1668 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1668 ZOBELLIA_1669 ZOBELLIA_1669 ZOBELLIA_1669 1966059 1968461 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-99) and the Plug module (120-216) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene1669 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1669 ZOBELLIA_167 ZOBELLIA_167 ZOBELLIA_167 188622 189371 - CAAX prenyl peptidase%2C family U48 CAAX prenyl peptidase removes a AAX tripeptide from the C-terminal CAAX motif of a protein when a prenyl group is attached to the Cys residue. Putatively involved in protein modification and secretion or/and in the bacteriophage resistance. Belongs to the family U48 of the peptidases. The catalytic mechanism is still unknown. Contains five transmembrane segments. Protein localized in the cytoplasmic membrane.%3B~Family membership gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_167 ZOBELLIA_1670 ZOBELLIA_1670 ZOBELLIA_1670 1968610 1968708 + Putative protein Hypothetical protein gene gene1670 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1670 ZOBELLIA_1671 ZOBELLIA_1671 lepA lepA 1968783 1970618 + Elongation factor LepA LepA is a GTP-binding protein. Quin and collaborators (Cell%2C 2006) have recently demonstrated that LepA is a third elongation factor required for accurate and efficient protein synthesis. LepA has the unique function of back-translocating posttranslocational ribosomes. It recognizes ribosomes after a defective translocation reaction and induces a back-translocation%2C thus giving the elongation factor EF-G a second chance to translocate the tRNAs correctly. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1671 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1671 ZOBELLIA_1672 ZOBELLIA_1672 ZOBELLIA_1672 1970677 1971243 - Conserved hypothetical protein Localized in the cytoplasm. gene gene1672 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1672 ZOBELLIA_1673 ZOBELLIA_1673 ZOBELLIA_1673 1971302 1971538 + Conserved hypothetical protein Localized in the cytoplasm. gene gene1673 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1673 ZOBELLIA_1674 ZOBELLIA_1674 ZOBELLIA_1674 1971566 1973434 - Sodium/hydrogen exchanger Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. This integral membrane protein also contains a C-terminal TrkA- N domain which binds NAD and adopts a Rossmann fold%2C Contains twelve transmembrane helices%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1674 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1674 ZOBELLIA_1675 ZOBELLIA_1675 ZOBELLIA_1675 1973670 1975451 + Sodium/hydrogen exchanger Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. This integral membrane protein also contains a C-terminal TrkA- N domain which binds NAD and adopts a Rossmann fold%3B Contains twelve transmembrane helices%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1675 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1675 ZOBELLIA_1676 ZOBELLIA_1676 ZOBELLIA_1676 1975457 1975609 - Putative protein Hypothetical protein gene gene1676 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1676 ZOBELLIA_1677 ZOBELLIA_1677 ZOBELLIA_1677 1975651 1976511 + Metal-dependent hydrolase Conserved protein belonging to the metallo beta-lactamase superfamily. The histidine residues which coordinate the zinc ions are strictly conserved in this protein%2C suggesting that it is a metal-dependent hydrolase. But its exact function is still unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene1677 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1677 ZOBELLIA_1678 ZOBELLIA_1678 ZOBELLIA_1678 1976891 1978522 + Serine endopeptidase%2C family S8 The Serine endopeptidases use a catalytic serine residue as a nucleophile and form an acyl intermediate. These peptidases can also readily act as transferases%3B Belongs to the families S8 of peptidases%2C clan SB%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the cytoplasmic and/or outer membrane%3B~Family membership gene gene1678 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1678 ZOBELLIA_1679 ZOBELLIA_1679 ZOBELLIA_1679 1978528 1980387 + Aminopeptidase%2C family M1 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. This enzyme belongs to the family M1 of the peptidases. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm.%3B~Specificity unclear gene gene1679 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1679 ZOBELLIA_168 ZOBELLIA_168 ZOBELLIA_168 189675 190175 - Conserved hypothetical protein Localized in the cytoplasm gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_168 ZOBELLIA_1680 ZOBELLIA_1680 rnpA rnpA 1980467 1980844 + Ribonuclease P protein component Ribonuclease P (RNaseP) consists of a catalytic RNA component (M1 or rnpB) and a protein subunit . RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1680 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1680 ZOBELLIA_1681 ZOBELLIA_1681 ZOBELLIA_1681 1980910 1982541 + Carboxy-terminal processing peptidase%2C family S41 This enzyme is a modular protein with a N-terminal PDZ domain%2C a central carboxy-terminal processing peptidase and a C-terminal domain of unknown function. The catalytic module belongs to the family S41 of the peptidase. It shows specific recognition of a C-terminal tripeptide%2C Xaa-Yaa-Zaa%2C in which Xaa is preferably Ala or Leu%2C Yaa is preferably Ala or Tyr%2C and Zaa is preferably Ala%2C but then cleaves at a variable distance from the C- terminus. PDZ domains are multifunctional protein-protein interaction modules. In many cases%2C PDZ domains bind to a signature motif ([FYST]-X-[FVA]) occurring at the very C- terminus of target proteins. Features an uncleaved signal peptide.%3B~High confidence in function and specificity gene gene1681 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1681 ZOBELLIA_1682 ZOBELLIA_1682 ZOBELLIA_1682 1982564 1982950 + Glyoxalase superfamily protein Family membership gene gene1682 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1682 ZOBELLIA_1683 ZOBELLIA_1683 ZOBELLIA_1683 1982962 1983756 - Conserved hypothetical lipoprotein Contains a domain of unknown function (DUF1080) that may adopt a concavalin-like or glucanase-like fold%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1683 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1683 ZOBELLIA_1684 ZOBELLIA_1684 ZOBELLIA_1684 1983797 1984837 - Conserved hypothetical membrane protein Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1684 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1684 ZOBELLIA_1685 ZOBELLIA_1685 afcA3 afcA3 1985074 1987497 + Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Signal peptide cleaved between the residues 34 and 35. Localized in the periplasmic space%3B~High confidence in function and specificity gene gene1685 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1685 ZOBELLIA_1686 ZOBELLIA_1686 ZOBELLIA_1686 1987551 1989680 + Pyrroloquinoline quinone-dependent dehydrogenase Dehydrogenase with a N-terminal domain that adopts a beta-propeller fold and binds the pyrroloquinoline quinone (PQQ) as prosthetic group. Contains also a C-type cytochrome domain with a heme group covalently bound by thioether bonds to two conserved cysteine residues%3B Belongs to the Quinoprotein alcohol dehydrogenase family%3B Putative lipoprotein signal peptide cleaved between the residues 21 and 22%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene1686 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1686 ZOBELLIA_1687 ZOBELLIA_1687 ZOBELLIA_1687 1989790 1990656 + Fructosamine kinase Fructosamine kinase is responsible for the removal of fructosamines from proteins%2C by a sugar phosphorylation mechanism%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1687 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1687 ZOBELLIA_1688 ZOBELLIA_1688 ZOBELLIA_1688 1991008 1991706 + Conserved hypothetical protein Localized in the cytoplasm gene gene1688 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1688 ZOBELLIA_1689 ZOBELLIA_1689 ZOBELLIA_1689 1991706 1993049 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1689 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1689 ZOBELLIA_169 ZOBELLIA_169 ZOBELLIA_169 190318 194457 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_169 ZOBELLIA_1690 ZOBELLIA_1690 ZOBELLIA_1690 1993052 1993648 + Conserved hypothetical protein Protein that contains three repeats of twenty aminoacids The MORN (membrane occupation and recognition nexus) repeats would contribute to the plasma membrane binding%2C possibly by interacting with phospholipids%3B Seems localized in the cytoplasm gene gene1690 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1690 ZOBELLIA_1691 ZOBELLIA_1691 ZOBELLIA_1691 1993978 1994421 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1691 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1691 ZOBELLIA_1692 ZOBELLIA_1692 ZOBELLIA_1692 1994552 1995745 - Dipeptidyl peptidase%2C family C40 Dipeptidyl peptidase hydrolyzes gamma-D-Glu-L-(meso)A2pm linkages only in those peptide units that have a free N-terminal L-alanine. It is involved in peptidoglycan metabolism%3B Belongs to the family C40 of peptidases%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene1692 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1692 ZOBELLIA_1693 ZOBELLIA_1693 ZOBELLIA_1693 1995829 1997055 + DNA (cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase specifically methylates the C-5 carbon of cytosines in DNA to produce C5-methylcytosine. It uses S-adenosyl-L-methionine as methyl donor. This protein is highly%3B~High confidence in function and specificity gene gene1693 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1693 ZOBELLIA_1694 ZOBELLIA_1694 ZOBELLIA_1694 1997086 1997700 + Conserved hypothetical protein Localized in the cytoplasm gene gene1694 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1694 ZOBELLIA_1695 ZOBELLIA_1695 ZOBELLIA_1695 1997958 1998332 + Conserved hypothetical protein Localized in the cytoplasm gene gene1695 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1695 ZOBELLIA_1696 ZOBELLIA_1696 elaA elaA 1998380 1998823 - N-acetyltransferase ElaA N-acetyltransferase belonging to the GCN5 family%2C but its exact specificity is unknown%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1696 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1696 ZOBELLIA_1697 ZOBELLIA_1697 ZOBELLIA_1697 1998828 1999745 - Cation efflux protein This integral membrane protein belongs to a family of proteins that are found to increase tolerance to divalent metal ions such as cadmium%2C zinc%2C and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells. Features six transmembrane helices.%3B~Specificity unclear gene gene1697 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1697 ZOBELLIA_1698 ZOBELLIA_1698 rpiB rpiB 1999898 2000329 - Ribose-5-phosphate isomerase B Ribose 5-phosphate isomerase B catalyses the conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway%3B Forms a homodimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1698 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1698 ZOBELLIA_1699 ZOBELLIA_1699 vacB vacB 2000994 2003189 + Ribonuclease R Ribonuclease R is a 3'-5'exoribonuclease that acts nonspecifically on poly(A)%2C poly(U) and ribosomal RNAs%3B RNase R degrades RNA with secondary structure having a 3'overhang of at least 7 nucleotides. RNase R and polynucleotide phosphorylase play an important role in the degradation of RNA with extensive secondary structure%2C (rRNA%2C tRNA%2C and certain mRNA) which contains repetitive extragenic palindromic sequences. Contains a C-terminal S1 domain that binds ssRNA. Forms a monomer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1699 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1699 ZOBELLIA_17 ZOBELLIA_17 ZOBELLIA_17 17566 18423 + Putative membrane lipoprotein Lipoprotein signal peptide cleaved between the residues 16 and 17%3B Putatively localized in the outer membrane%3B~Hypothetical protein gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_17 ZOBELLIA_170 ZOBELLIA_170 ZOBELLIA_170 194611 195105 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_170 ZOBELLIA_1700 ZOBELLIA_1700 ZOBELLIA_1700 2003246 2003926 + Conserved hypothetical protein Localized in the cytoplasm gene gene1700 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1700 ZOBELLIA_1701 ZOBELLIA_1701 ZOBELLIA_1701 2004042 2004710 + LysE-type amino acid translocator This conserved integral membrane protein is likely an amino acid translocator%3B Contains six transmembrane helices%3B belongs to the LysE family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1701 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1701 ZOBELLIA_1703 ZOBELLIA_1703 folB folB 2005016 2005378 - Dihydroneopterin aldolase Dihydroneopterin aldolase catalyses the conversion of 7%2C8-dihydroneopterin to 6-hydroxymethyl-7%2C8-dihydropterin in the biosynthetic pathway of tetrahydrofolate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1703 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1703 ZOBELLIA_1704 ZOBELLIA_1704 ZOBELLIA_1704 2005489 2006442 - Conserved hypothetical protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space gene gene1704 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1704 ZOBELLIA_1705 ZOBELLIA_1705 ZOBELLIA_1705 2020487 2020732 + Putative protein Hypothetical protein gene gene1706 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1705 ZOBELLIA_1706 ZOBELLIA_1706 ZOBELLIA_1706 2006474 2021098 - Conserved hypothetical protein Putatively contains a B_ant_repeat domain (DUF 11) and a Concanavalin A-like lectin/glucanase domain in the N-terminal region%3B Contains also at least four BNR/Asp-box repeats (bacterial neuraminidase repeat) found in many glycoside hydrolases and in other extracellular proteins of unknown function%3B Signal peptide cleaved between the residues 23 and 24%3B Probably localized in the outer membrane gene gene1705 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1706 ZOBELLIA_1707 ZOBELLIA_1707 ZOBELLIA_1707 2021099 2023210 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1707 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1707 ZOBELLIA_1708 ZOBELLIA_1708 ZOBELLIA_1708 2023221 2025494 - Conserved hypothetical periplasmic protein Contains a central Ig-like domain (residues 511-592)%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1708 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1708 ZOBELLIA_1709 ZOBELLIA_1709 glnS glnS 2025715 2027397 + Glutaminyl-tRNA synthetase Glutaminyl-tRNA synthetase is a class Ic synthetase and catalyzes the attachment of glutamine to its cognate transfer RNA molecule. This monomeric enzyme has an architecture%3B~High confidence in function and specificity gene gene1709 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1709 ZOBELLIA_171 ZOBELLIA_171 talA1 talA1 195354 196010 - Transaldolase Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. It catalyzes the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme%2C together with transketolase%2C provides a link between the Embden-Meyerhof pathway and the non-oxidative phase of pentose-phosphate pathway%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_171 ZOBELLIA_1710 ZOBELLIA_1710 ZOBELLIA_1710 2027803 2028132 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1710 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1710 ZOBELLIA_1711 ZOBELLIA_1711 ZOBELLIA_1711 2028136 2028486 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1711 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1711 ZOBELLIA_1712 ZOBELLIA_1712 ZOBELLIA_1712 2028483 2028698 + Conserved hypothetical protein Localized in the cytoplasm. gene gene1712 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1712 ZOBELLIA_1713 ZOBELLIA_1713 ZOBELLIA_1713 2028789 2029721 - Band 7 family protein The Band 7 protein is an integral membrane phosphoprotein of red blood cells thought to regulate cation conductance. Bacterial homologues are known%2C but their exact function is uncertain%3B Contains a N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1713 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1713 ZOBELLIA_1714 ZOBELLIA_1714 gltX gltX 2029907 2031415 - Glutamyl-tRNA synthetase Glutamyl-tRNA synthetase (GluRS) is a monomeric enzyme that catalyzes the attachment of glutamate to its cognate transfer RNA molecule in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Binds 1 zinc ion per subunit%3B Belongs to the class-I aminoacyl-tRNA synthetase family%2C subclasse c%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1714 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1714 ZOBELLIA_1715 ZOBELLIA_1715 ZOBELLIA_1715 2031548 2035009 + Conserved hypothetical membrane protein Contains three transmembrane helices in the N-terminal region%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1715 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1715 ZOBELLIA_1716 ZOBELLIA_1716 ZOBELLIA_1716 2035002 2035421 + Conserved hypothetical protein Conserved protein belonging to the UPF0054 family%3B Localized in the cytoplasm%3B~Family membership gene gene1716 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1716 ZOBELLIA_1717 ZOBELLIA_1717 mnmG mnmG 2035485 2037353 + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG The protein MnmG (or GidA glucose-inhibited division protein A) is a NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA-cmnm5s2U34%3B Binds the FAD as cofactor%3B Homodimer that forms a heterotetramer of two MnmE and two MnmG subunits%3B Belongs to the MnmG family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1717 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1717 ZOBELLIA_1718 ZOBELLIA_1718 ZOBELLIA_1718 2037504 2037734 + Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1718 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1718 ZOBELLIA_1719 ZOBELLIA_1719 ZOBELLIA_1719 2037951 2038094 - Putative protein Hypothetical protein gene gene1719 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1719 ZOBELLIA_172 ZOBELLIA_172 xylA xylA 196022 197347 - Xylose isomerase Xylose isomerase is involved in xylose metabolism. It catalyzes the conversion of D-xylose into D-xylulose. It forms a homotetramer and binds 2 magnesium ions per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_172 ZOBELLIA_1720 ZOBELLIA_1720 ZOBELLIA_1720 2038151 2038981 + SAM-dependent methyltransferase This protein display a SAM-binding domain and is likely a methyltransferase. S-adenosyl-L-methionine (SAM) is a ubiquitous methyl donor%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1720 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1720 ZOBELLIA_1721 ZOBELLIA_1721 ZOBELLIA_1721 2039360 2039869 + Outer membrane protein%2C OmpH family Outer membrane protein belonging to the OmpH family. OmpH acts as a channel-forming transmembrane porin. OmpH is a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery%3B Localized in the outer membrane%3B~Family membership gene gene1721 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1721 ZOBELLIA_1722 ZOBELLIA_1722 ZOBELLIA_1722 2039926 2040324 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1722 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1722 ZOBELLIA_1723 ZOBELLIA_1723 holB holB 2040387 2041538 - DNA polymerase III%2C delta prime chain The delta prime subunit of DNA polymerase III is part of the 'clamp' loading complex that assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork%3B The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1723 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1723 ZOBELLIA_1724 ZOBELLIA_1724 pgkA pgkA 2041681 2042871 + Phosphoglycerate kinase Phosphoglycerate kinase transfers a phosphate group from 1%2C3-biphosphoglycerate to ADP%2C forming ATP and 3-Phosphoglycerate in the seventh step of the glycolysis Embden-Meyerhof pathway). PgkA exists as a monomer containing two nearly equal-sized domains that correspond to the N- and C-termini of the protein. 3-phosphoglycerate binds to the N-terminal%2C while the nucleotide substrates%2C MgATP or MgADP%2C bind to the C-terminal domain of the enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1724 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1724 ZOBELLIA_1725 ZOBELLIA_1725 ZOBELLIA_1725 2043026 2044669 + Lytic murein transglycosylase%2C family GH23 Lytic murein transglycosylase catalyzes the cleavage of the beta-1%2C4-glycosidic bond between N- acetylmuramic acid and N-acetylglucosamine residues%2C thereby conserving the energy in a newly synthesized 1%2C6- anhydrobond in the muramic acid residue. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Contains a N-terminal catalytic module belonging to the family 23 of the glycoside hydrolases (GH23) and two C-terminal LysM domains%2C predicted to bind peptidoglycans and belonging to the family 50 of the carbohydrate binding modules (CBM50)%3B Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasm%3B~Specificity unclear gene gene1725 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1725 ZOBELLIA_1726 ZOBELLIA_1726 ZOBELLIA_1726 2044683 2045678 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1726 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1726 ZOBELLIA_1727 ZOBELLIA_1727 ZOBELLIA_1727 2046085 2048619 - OmpA-like outer membrane protein This protein has a modular architecture with a N-terminal domain of unknown function%2C a central beta-propeller domain%2C encompassing three WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan. Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Function unclear gene gene1727 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1727 ZOBELLIA_1728 ZOBELLIA_1728 tatA tatA 2048980 2049162 - Sec-independent protein translocase TatA The TatA protein is required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. TatA seems to form the protein-conducting channel of the TAT system%3B Contains one N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1728 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1728 ZOBELLIA_1729 ZOBELLIA_1729 ZOBELLIA_1729 2049358 2050224 + Metallopeptidase%2C family M23 Peptidase family M23 mainly contains endopeptidases that lyze bacterial cell wall peptidoglycans. One catalytic zinc ion is bound per peptidase molecule. The cation ligands occur in the conserved motifs HXXXD and HXH. The first histidine of the second motif is also involved in the catalysis. Contains a transmembrane helix in N-terminus. Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1729 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1729 ZOBELLIA_173 ZOBELLIA_173 xylB xylB 197349 198833 - Xylulose kinase Xylulose kinase is involved in xylose catabolism. It catalyzes the reaction: ATP + D-xylulose %3D ADP + D-xylulose 5-phosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_173 ZOBELLIA_1730 ZOBELLIA_1730 ZOBELLIA_1730 2050300 2051796 + Conserved hypothetical protein Conserved hypothetical protein distantly related to the Auxin-responsive GH3-like proteins%3B Localized in the cytoplasm gene gene1730 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1730 ZOBELLIA_1731 ZOBELLIA_1731 ZOBELLIA_1731 2051771 2051866 + Putative protein Hypothetical protein gene gene1731 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1731 ZOBELLIA_1732 ZOBELLIA_1732 ZOBELLIA_1732 2051952 2053637 + Conserved hypothetical protein Localized in the cytoplasm gene gene1732 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1732 ZOBELLIA_1733 ZOBELLIA_1733 ZOBELLIA_1733 2053641 2054648 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1733 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1733 ZOBELLIA_1734 ZOBELLIA_1734 rmlB rmlB 2054659 2055681 + dTDP-glucose 4%2C6-dehydratase dTDP-glucose 4%2C6-dehydratase converts the dTDP-glucose to dTDP-4-dehydro-6-deoxy-D-glucose. This enzyme is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis%3B Belongs to the NAD dependent epimerase/dehydratase family%2C Rossmann fold Superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1734 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1734 ZOBELLIA_1735 ZOBELLIA_1735 rmlA rmlA 2055685 2056539 + Glucose-1-phosphate thymidylyltransferase Glucose-1-phosphate thymidylyltransferase transferts the dTDP on glucose molecule from dTTP and alpha-D-glucose-1-phosphate. This enzyme is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis. RmlA forms a homotetramer and binds one Mg2+ per subunit%3B Belongs to the nucleotidyl transferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1735 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1735 ZOBELLIA_1736 ZOBELLIA_1736 rmlC rmlC 2056558 2057103 + dTDP-4-dehydrorhamnose 3%2C5-epimerase dTDP-4-dehydrorhamnose 3%2C5-epimerase converts the dTDP-4-dehydro-6-deoxy-D-glucose to dTDP-4-dehydro-6-deoxy-L-mannose. RmlC is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis%3B forms a homodimer%3B Belongs to the Cupin fold clan%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1736 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1736 ZOBELLIA_1737 ZOBELLIA_1737 rmlD rmlD 2057100 2057876 + dTDP-4-dehydrorhamnose reductase dTDP-4-dehydrorhamnose reductase converts the dTDP-6-deoxy-L-mannose to dTDP-4-dehydro-6-deoxy-L-mannose. RmlD is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis%3B Belongs to the RmlD substrate binding domain family%2C Rossmann fold Superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1737 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1737 ZOBELLIA_1738 ZOBELLIA_1738 fdtC fdtC 2057895 2058476 + dTDP-D-Fucp3N acetylase dTDP-D-Fucp3N acetylase catalyzes the transfer of an acetyl group from acetyl-CoA to dTDP-D-Fucp3N to form dTDP-D-Fucp3NAc. FdtC is involved in the biosynthesis of lipopolysaccharides%3B Belongs to the o-acetyltransferase family%3B Contains five tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which folds as a left-handed parallel beta helix%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1738 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1738 ZOBELLIA_1739 ZOBELLIA_1739 fdtB fdtB 2058497 2059594 + dTDP-6-deoxy-D-xylo-hex-3-ulose aminase The dTDP-6-deoxy-D-xylo-hex-3-ulose aminase aminates specifically dTDP-6-deoxy-D-xylo-hex-3-ulose to form dTP-D-Fucp3N. FdtB%2C involved in the biosynthesis of lipopolysaccharides%2C requires pyridoxal-phosphate and L-glutamate as cofactors%3B Belongs to the DegT/DnrJ/EryC1/StrS aminotransferase family%2C PLP dependent aminotransferase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1739 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1739 ZOBELLIA_174 ZOBELLIA_174 ZOBELLIA_174 199166 200191 + LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_174 ZOBELLIA_1740 ZOBELLIA_1740 wbpB wbpB 2059591 2060529 + Lipopolysaccharide biosynthesis protein WbpB WbpB is a NAD(P)-dependent oxidoreductase involved in lipopolysaccharide biosynthesis%3B Belongs to the GFO/IDH/MOCA family%3B Adopts a Rossmann fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1740 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1740 ZOBELLIA_1741 ZOBELLIA_1741 wecB wecB 2060542 2061591 + UDP-N-acetylglucosamine 2-epimerase UDP-N-acetylglucosamine 2-epimerase converts the UDP-N-acetyl-D-glucosamine to UDP-N-acetyl-D-mannosamine. WecB is involved in amino sugar metabolism and in the lipopolysaccharide biosynthesis%3B Belongs to the UDP-Glycosyltransferase/glycogen phosphorylase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1741 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1741 ZOBELLIA_1742 ZOBELLIA_1742 wzxA wzxA 2061600 2062901 + O-antigen translocase WzxA translocates undecaprenylpyrophosphate-bound O-antigen subunits from the cytoplasm to the periplasm. Wzx is an integral membrane protein involved in lipopolysaccharide biosynthesis%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1742 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1742 ZOBELLIA_1743 ZOBELLIA_1743 ZOBELLIA_1743 2062891 2064462 + Conserved hypothetical protein Localized in the cytoplasm gene gene1743 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1743 ZOBELLIA_1744 ZOBELLIA_1744 capJ capJ 2064462 2065019 + Capsular polysaccharide synthesis O-acetyltransferase CapJ CapJ is involved in the capsular polysaccharide biosynthesis. Its features three tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which folds as a left-handed parallel beta helix%3B Belongs to the o-acetyltransferase family%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1744 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1744 ZOBELLIA_1745 ZOBELLIA_1745 wbmB wbmB 2065103 2066233 + O antigen biosynthesis protein WbmB The protein WbmB was first found in an O antigen biosynthesis operon from the genus Bordetella. Its exact function is still unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene1745 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1745 ZOBELLIA_1746 ZOBELLIA_1746 ZOBELLIA_1746 2066300 2067538 + Hypothetical membrane protein Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1746 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1746 ZOBELLIA_1747 ZOBELLIA_1747 wbeiA wbeiA 2067535 2068758 + O antigen biosynthesis protein WbeiA The protein WbeiA was first found in an O antigen biosynthesis gene cluster from Edwardsiella ictaluri. Its exact function is still unknown%3B Contains eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1747 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1747 ZOBELLIA_1748 ZOBELLIA_1748 ZOBELLIA_1748 2068745 2069542 + Glycosyltransferase%2C family GT2 Glycosyltransferase putatively involved in the Lipopolysaccharide core or in the exopolysaccharide biosynthesis%3B Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Contains a C-terminal transmembrane segment%3B Belongs to the family 2 of glycosyl transferase (GT2)%2C WaaE/kdtX subfamily%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1748 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1748 ZOBELLIA_1749 ZOBELLIA_1749 wbgV wbgV 2069539 2070783 + O antigen biosynthesis protein WbgV The protein WbgV was first found in an O antigen biosynthesis gene cluster in Enterobacteriaceae. Its exact function is still unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene1749 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1749 ZOBELLIA_175 ZOBELLIA_175 ZOBELLIA_175 200205 202310 - Conserved hypothetical membrane protein Contains five transmembrane helices in the N-terminal region%3B Contains a central motif reminiscent of the Planctomycete cytochrome C motif%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_175 ZOBELLIA_1750 ZOBELLIA_1750 ZOBELLIA_1750 2070797 2071537 + Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme is closely related to TuaG protein which is involved in the biosynthesis of theichuronic acid%2C a cell wall anionic polysaccharide in Firmicutes%3B Belongs to the family 2 of the glycosyltransferases (GT2)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1750 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1750 ZOBELLIA_1751 ZOBELLIA_1751 ZOBELLIA_1751 2071555 2072922 + Exopolysaccharide production protein Protein involved in exopolysaccharide biosynthesis. Its exact function is unknown%3B Contains five transmembrane helices Localized in the cytoplasmic membrane%3B~Function unclear gene gene1751 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1751 ZOBELLIA_1752 ZOBELLIA_1752 purD purD 2073042 2074313 + Phosphoribosylamine glycine ligase Phosphoribosylamine glycine ligase (also known as phosphoribosylglycinamide synthetase) catalyses the second step in the de novo biosynthesis of purine: the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1752 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1752 ZOBELLIA_1753 ZOBELLIA_1753 ZOBELLIA_1753 2074362 2074583 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1753 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1753 ZOBELLIA_1754 ZOBELLIA_1754 ZOBELLIA_1754 2074775 2075713 + Conserved hypothetical membrane protein Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1754 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1754 ZOBELLIA_1755 ZOBELLIA_1755 ZOBELLIA_1755 2075749 2076351 + Conserved hypothetical protein Localized in the cytoplasm gene gene1755 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1755 ZOBELLIA_1756 ZOBELLIA_1756 ZOBELLIA_1756 2076386 2077387 + Lipopolysaccharide core biosynthesis glycosyltransferase%2C family GT9 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme is a glycosyltransferase involved in the biosynthesis of the lipopolysaccharide core%3B Belongs to the family 9 of the glycosyltransferase (GT9)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1756 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1756 ZOBELLIA_1757 ZOBELLIA_1757 ZOBELLIA_1757 2077394 2078050 - TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene1757 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1757 ZOBELLIA_1758 ZOBELLIA_1758 ZOBELLIA_1758 2078379 2079089 + Conserved hypothetical protein Localized in the cytoplasm gene gene1758 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1758 ZOBELLIA_1759 ZOBELLIA_1759 ZOBELLIA_1759 2079184 2082402 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (24-82) and the Plug module (113-241) acting as a channel gate%3B The signal peptide is cleaved between the residues 22 and 23%3B~Family membership gene gene1759 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1759 ZOBELLIA_176 ZOBELLIA_176 ZOBELLIA_176 202315 203769 - Conserved hypothetical periplasmic protein Protein containing a domain of unknown function DUF1501%3B Belongs to the alkaline-phosphatase clan%3B Contains a twin-arginine signal peptide%3B Localized in the periplasmic space%3B~Family membership gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_176 ZOBELLIA_1760 ZOBELLIA_1760 ZOBELLIA_1760 2082415 2083884 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 27 and 28%3B Probably localized in the outer membrane%3B~Family membership gene gene1760 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1760 ZOBELLIA_1761 ZOBELLIA_1761 ZOBELLIA_1761 2083964 2085187 + ABC importer%2C periplasmic component Periplasmic lipoprotein of unknown function that is a part of an ABC transporter system%3B Belongs to the periplasmic substrate-binding ABC transporter superfamily%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasm space putatively anchored in the cytoplasmic membrane%3B~Specificity unclear gene gene1761 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1761 ZOBELLIA_1762 ZOBELLIA_1762 ZOBELLIA_1762 2085177 2086031 + ABC importer%2C permease component ABC (ATP-binding cassette) transporter%2C membrane domain%3B Proteins responsible for import of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1762 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1762 ZOBELLIA_1763 ZOBELLIA_1763 ZOBELLIA_1763 2086021 2086794 + ABC importer%2C permease component ABC (ATP-binding cassette) transporter%2C membrane domain%3B Proteins responsible for import of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1763 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1763 ZOBELLIA_1764 ZOBELLIA_1764 ZOBELLIA_1764 2086794 2087513 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes of the permease component (ABC membrane)%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~Family membership gene gene1764 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1764 ZOBELLIA_1765 ZOBELLIA_1765 ZOBELLIA_1765 2087563 2088483 + Ribonucleoside hydrolase Ribonucleoside hydrolase catalyzes the hydrolysis of purine and pyrimidine nucleosides into ribose and the associated base%3B Belongs to the IUNH family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1765 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1765 ZOBELLIA_1766 ZOBELLIA_1766 ZOBELLIA_1766 2088518 2089303 + Patatin-like phospholipase Conserved protein belonging to the Patatin-like phospholipase family%3B Localized in the cytoplasm%3B~Family membership gene gene1766 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1766 ZOBELLIA_1767 ZOBELLIA_1767 paaE paaE 2089345 2090394 - Phenylacetic acid degradation NADH oxidoreductase The protein PaaE is involved in the phenylacetic acid aerobic catabolism. It is likely part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation. It is activated by cAMP receptor protein (CRP) and the integration host factor (IHF). Contains a N-terminal FAD-binding domain%2C a central feredoxin-like NAD-binding domain and a C-terminal 2Fe-2S iron-sulfur cluster binding domain%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1767 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1767 ZOBELLIA_1768 ZOBELLIA_1768 ZOBELLIA_1768 2090504 2090860 + PadR-type transcriptional regulator Transcriptional regulator belonging to the PadR family. Features a helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Specificity unclear gene gene1768 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1768 ZOBELLIA_1769 ZOBELLIA_1769 ZOBELLIA_1769 2090934 2091644 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1769 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1769 ZOBELLIA_177 ZOBELLIA_177 ZOBELLIA_177 203786 206089 - Cytochrome c-containing protein This protein has a modular architecture with a N-terminal cytochrome C and two domains of unknown function%2C a DUF1549 domain which includes a second cytochrome C and a C-terminal DUF1553 domain. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes. Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Function unclear gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_177 ZOBELLIA_1770 ZOBELLIA_1770 ZOBELLIA_1770 2091706 2093175 + Conserved hypothetical membrane protein Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1770 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1770 ZOBELLIA_1771 ZOBELLIA_1771 ZOBELLIA_1771 2093230 2093958 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B~Family membership gene gene1771 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1771 ZOBELLIA_1772 ZOBELLIA_1772 ZOBELLIA_1772 2094016 2094297 - Putative protein Hypothetical protein gene gene1772 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1772 ZOBELLIA_1773 ZOBELLIA_1773 sprE sprE 2094476 2097028 + Gliding motility membrane lipoprotein SprE The SprE protein could be involved in the gliding motility%3B Contains four tetratrico peptide repeats (TPRs). TPRs mediate proteinprotein interactions. TPR adopts a helixturnhelix arrangement%2C with adjacent TPR motifs packing in a parallel fashion%2C resulting in a spiral of repeating anti-parallel alpha-helices. SprE contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Function unclear gene gene1773 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1773 ZOBELLIA_1774 ZOBELLIA_1774 ZOBELLIA_1774 2097032 2097472 + Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF583 family%3B Localized in the cytoplasm gene gene1774 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1774 ZOBELLIA_1775 ZOBELLIA_1775 ZOBELLIA_1775 2097450 2097674 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1775 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1775 ZOBELLIA_1776 ZOBELLIA_1776 ZOBELLIA_1776 2097677 2098063 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1776 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1776 ZOBELLIA_1777 ZOBELLIA_1777 atpB1 atpB1 2098177 2099337 + ATP synthase%2C F0 sector A subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). The A subunit is a key membrane component of the proton channel%2C and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring%2C which in turn is driven by the flux of protons through the membrane via the interface between the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain%2C and is thought to act as a stator to counter the tendency of subunit A and the F1 alpha-beta catalytic portion to rotate with the central rotary element.%3B~High confidence in function and specificity gene gene1777 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1777 ZOBELLIA_1778 ZOBELLIA_1778 atpE1 atpE1 2099376 2099564 + ATP synthase%2C F0 sector C subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). Ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring%2C which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor.%3B~High confidence in function and specificity gene gene1778 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1778 ZOBELLIA_1779 ZOBELLIA_1779 atpF1 atpF1 2099654 2100154 + ATP synthase%2C F0 sector B subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). The B subunits are part of the peripheral stalk that links the F1 and F0 complexes together%2C and which acts as a stator to prevent certain subunits from rotating with the central rotary element.%3B~High confidence in function and specificity gene gene1779 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1779 ZOBELLIA_178 ZOBELLIA_178 ZOBELLIA_178 206093 207148 - conserved hypothetical periplasmic protein This protein likely adopts a beta-propeller fold%3B Contains a twin-arginine signal peptide%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_178 ZOBELLIA_1780 ZOBELLIA_1780 atpH atpH 2100221 2100760 + ATP synthase%2C F1 sector delta subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). The delta subunit appears to be part of the peripheral stalk that holds the F1 complex alpha-beta catalytic core stationary against the torque of the rotating central stalk%2C and links subunit A of the F0 complex with the F1 complex.%3B~High confidence in function and specificity gene gene1780 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1780 ZOBELLIA_1781 ZOBELLIA_1781 atpA1 atpA1 2100816 2102396 + ATP synthase%2C F1 sector alpha subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). There are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex%2C while the remaining F1 subunits (gamma%2C delta%2C epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits%2C those on the beta subunits being catalytic%2C while those on the alpha subunits are regulatory. The alpha and beta subunits form a cylinder that is attached to the central stalk. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP%2C which are induced by the rotation of the gamma subunit%2C itself is driven by the movement of protons through the F0 complex C subunit.%3B~High confidence in function and specificity gene gene1781 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1781 ZOBELLIA_1782 ZOBELLIA_1782 atpG1 atpG1 2102479 2103339 + ATP synthase%2C F1 sector gamma subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). In the F1 complex%2C the central gamma subunit forms the rotor inside the cylinder made of the alpha beta subunits%2C while in the F0 complex%2C the ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions%2C but the F0 rotor is usually stronger%2C using the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis.%3B~High confidence in function and specificity gene gene1782 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1782 ZOBELLIA_1783 ZOBELLIA_1783 ZOBELLIA_1783 2103504 2103740 - Putative protein Hypothetical protein gene gene1783 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1783 ZOBELLIA_1784 ZOBELLIA_1784 mdtK mdtK 2103871 2105181 + Multidrug resistance protein Multidrug efflux pump that functions probably as a Na(+)/drug antiporter%3B Contains 12 transmembrane segments%3B Belongs to the multi antimicrobial extrusion (MATE) family%2C MdtK subfamily%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1784 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1784 ZOBELLIA_1785 ZOBELLIA_1785 dut dut 2105254 2105688 + Deoxyuridine 5'-triphosphate nucleotidohydrolase Deoxyuridine 5'-triphosphate nucleotidohydrolase is involved in nucleotide metabolism: it produces dUMP%2C the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. This enzyme forms a homotrimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1785 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1785 ZOBELLIA_1786 ZOBELLIA_1786 ZOBELLIA_1786 2105724 2106665 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1786 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1786 ZOBELLIA_1787 ZOBELLIA_1787 ZOBELLIA_1787 2106681 2107475 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 22 and 23%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1787 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1787 ZOBELLIA_1788 ZOBELLIA_1788 ZOBELLIA_1788 2107465 2108694 + Family M23 non-peptidase protein This protein displays significant similarity with the metallopeptidases from the family M23%2C but the ligands of the catalytic zinc are missing (motifs HXXXD and HXH). Peptidase family M23 mainly contains endopeptidases that lyze bacterial cell wall peptidoglycans%3B Contains a signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasm%3B~Function unclear gene gene1788 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1788 ZOBELLIA_1789 ZOBELLIA_1789 ZOBELLIA_1789 2108702 2109544 + Aldo/keto reductase related to diketogulonate reductase Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 1 family%3B Localized in the cytoplasm%3B~Family membership gene gene1789 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1789 ZOBELLIA_179 ZOBELLIA_179 ZOBELLIA_179 207267 211181 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains a transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_179 ZOBELLIA_1790 ZOBELLIA_1790 ZOBELLIA_1790 2109552 2110064 - Acyl-CoA thioesterase Acyl-CoA thioesterase hydrolyzes fatty acyl-CoA substrates releasing acyl-Coa and fatty acids%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1790 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1790 ZOBELLIA_1791 ZOBELLIA_1791 ZOBELLIA_1791 2110193 2111152 - Conserved hypothetical protein Localized in the cytoplasm gene gene1791 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1791 ZOBELLIA_1792 ZOBELLIA_1792 dprA dprA 2111258 2112361 + DNA processing protein Smf The protein Smf (or DprA) would be a new member of the recombination-mediator protein family%2C dedicated to natural bacterial transformation%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1792 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1792 ZOBELLIA_1793 ZOBELLIA_1793 trpS trpS 2112544 2113512 - Tryptophanyl-tRNA synthetase Tryptophanyl-tRNA synthetase catalyzes the attachment of tryptophan to its cognate transfer RNA molecule in a highly specific two-step reaction. TrpS forms a homodimer and adopts a characteristic Rossman fold%3B Belongs to the class I of the tryptophanyl-tRNA synthetase%2C subclass b%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1793 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1793 ZOBELLIA_1794 ZOBELLIA_1794 ZOBELLIA_1794 2113585 2114325 + Acyltransferase Acyltransferase of unkown specificity%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1794 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1794 ZOBELLIA_1795 ZOBELLIA_1795 ZOBELLIA_1795 2114359 2115279 - Conserved hypothetical membrane protein Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1795 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1795 ZOBELLIA_1796 ZOBELLIA_1796 ZOBELLIA_1796 2115355 2116239 - LysR-type transcriptional regulator Transcriptional regulator belonging to the LysR family. Features a N-terminal helix-turn-helix DNA binding domain and a C-terminal LysR-like substrate binding domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene1796 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1796 ZOBELLIA_1797 ZOBELLIA_1797 ZOBELLIA_1797 2116310 2117890 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1797 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1797 ZOBELLIA_1798 ZOBELLIA_1798 ZOBELLIA_1798 2118495 2118614 + Putative protein Hypothetical protein gene gene1799 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1798 ZOBELLIA_1799 ZOBELLIA_1799 ZOBELLIA_1799 2117946 2118518 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene1798 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1799 ZOBELLIA_18 ZOBELLIA_18 ZOBELLIA_18 18459 18701 + Putative membrane protein Contains two transmembrane segmemnts%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_18 ZOBELLIA_180 ZOBELLIA_180 ZOBELLIA_180 211202 211351 - Putative protein Hypothetical protein gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_180 ZOBELLIA_1800 ZOBELLIA_1800 ZOBELLIA_1800 2118621 2119055 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1800 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1800 ZOBELLIA_1801 ZOBELLIA_1801 recA recA 2119209 2120216 - Recombinase A Recombinase A is a multifunctional enzyme involved in homologous recombination%2C natural transformation%2C DNA repair and induction of the SOS response. It hydrolyzes the ATP in the presence of single-stranded DNA%2C the ATP-dependent uptake of single-stranded DNA by duplex DNA%2C and the ATP-dependent hybridization of homologous single-stranded DNAs. RecA also acts as a protease cofactor that promotes autodigestion of the LexA product and phage repressors. The proteolytic inactivation of the LexA repressor by an activated form of RecA may cause a derepression of the 20 or so genes involved in the SOS response%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1801 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1801 ZOBELLIA_1802 ZOBELLIA_1802 ZOBELLIA_1802 2120238 2120444 - Putative protein Hypothetical protein gene gene1802 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1802 ZOBELLIA_1803 ZOBELLIA_1803 ZOBELLIA_1803 2120743 2121774 + Conserved hypothetical protein Hypothetical sulfurtransferase that contains one rhodanese domain%2C Belongs to the UPF0176 family%3B localized in the cytoplasm gene gene1803 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1803 ZOBELLIA_1804 ZOBELLIA_1804 ZOBELLIA_1804 2121784 2123040 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 10 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1804 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1804 ZOBELLIA_1805 ZOBELLIA_1805 ZOBELLIA_1805 2123129 2124370 + Conserved hypothetical protein Protein highly Its role in Z. galactanivorans is unknown%3B Localized in the cytoplasm gene gene1805 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1805 ZOBELLIA_1806 ZOBELLIA_1806 gldH gldH 2124363 2124848 + Gliding motility membrane lipoprotein Lipoprotein involved in the gliding motility%3B Signal peptide cleaved between the residues 16 and 17%3B Probably localized in the outer membrane%3B~Function unclear gene gene1806 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1806 ZOBELLIA_1807 ZOBELLIA_1807 pbp1A pbp1A 2124852 2127203 + Penicillin-binding protein 1A%2C family GT51 Penicillin-binding protein 1A is a class A PBP involved in the synthesis of cross-linked peptidoglycan from the lipid II intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). The N-terminal domain belongs to the family 51 of the glycosyltransferases. Features an uncleaved signal peptide. Localized in the periplasm%2C anchored to the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1807 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1807 ZOBELLIA_1808 ZOBELLIA_1808 scoA scoA 2127320 2128018 + 3-Oxoacid CoA-transferase subunit A 3-Oxoacid CoA-transferase catalyzes the reaction: succinyl-CoA + a 3-oxo acid %3D succinate + a 3-oxoacyl-CoA. It is an homodimer of a subunit A and a subunit B. ScoA is the subunit A. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1808 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1808 ZOBELLIA_1809 ZOBELLIA_1809 scoB scoB 2128141 2128794 + 3-Oxoacid CoA-transferase subunit B 3-Oxoacid CoA-transferase catalyzes the reaction: succinyl-CoA + a 3-oxo acid %3D succinate + a 3-oxoacyl-CoA. It is an homodimer of a subunit A and a subunit B. ScoB is the subunit B. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1809 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1809 ZOBELLIA_181 ZOBELLIA_181 idsA1 idsA1 211464 213113 + Iduronate-2-sulfatase%2C family S1-7 Iduronate-2-sulfatase%2C called also Chondroitinsulfatase is involved in the glycosaminoglycan degradation. It hydrolyzes the 2-sulfate groups from non-reducing-terminal iduronic acid residues in dermatan sulfate and heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (formylglycine-dependent sulfatases)%2C subfamily 7%3B Putative lipoprotein with a signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_181 ZOBELLIA_1810 ZOBELLIA_1810 ZOBELLIA_1810 2128964 2129065 + Conserved hypothetical protein Localized in the cytoplasm. gene gene1810 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1810 ZOBELLIA_1811 ZOBELLIA_1811 ZOBELLIA_1811 2129157 2130314 - Aminotransferase Aminotransferases use the Pyridoxal phosphate as cofactor bound by covalent linkage to a lysine residue%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1811 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1811 ZOBELLIA_1812 ZOBELLIA_1812 ZOBELLIA_1812 2130352 2131404 + Conserved hypothetical protein Contains two transmembrane segments%3B Protein probably localized in the cytoplasmic membrane gene gene1812 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1812 ZOBELLIA_1813 ZOBELLIA_1813 ZOBELLIA_1813 2131455 2131703 + Putative protein Hypothetical protein gene gene1813 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1813 ZOBELLIA_1814 ZOBELLIA_1814 ZOBELLIA_1814 2131822 2132484 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal GAF domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1814 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1814 ZOBELLIA_1815 ZOBELLIA_1815 ZOBELLIA_1815 2132768 2133379 + Hypothetical lpoprotein Contains a N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG)%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1815 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1815 ZOBELLIA_1816 ZOBELLIA_1816 ZOBELLIA_1816 2133523 2134320 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1816 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1816 ZOBELLIA_1817 ZOBELLIA_1817 ZOBELLIA_1817 2134443 2135243 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1817 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1817 ZOBELLIA_1818 ZOBELLIA_1818 astE astE 2135438 2136418 - Succinylglutamate desuccinylase Succinylglutamate desuccinylase catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. It hydrolyzes 2-N-succinylglutamate into succinate and glutamate. It binds one zinc ion as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1818 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1818 ZOBELLIA_1819 ZOBELLIA_1819 rimK1 rimK1 2136445 2137308 - Ribosomal protein S6 modification protein RimK is responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6. This protein forms a dimer%3B Binds one ATP and 2 manganese ions by subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1819 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1819 ZOBELLIA_182 ZOBELLIA_182 ZOBELLIA_182 213110 213229 - Putative protein Hypothetical protein gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_182 ZOBELLIA_1820 ZOBELLIA_1820 ZOBELLIA_1820 2137351 2137473 - Putative protein Hypothetical protein gene gene1820 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1820 ZOBELLIA_1821 ZOBELLIA_1821 sdhC sdhC 2137621 2138289 + Succinate dehydrogenase cytochrome b558 subunit Succinate dehydrogenase is a complex containing three subunits: a flavoprotein%2C an iron-sulfur protein and cytochrome b-558. It is involved in the citrate cycle and catalyzes the reaction: succinate + acceptor %3D fumarate + reduced acceptor. It uses a FAD as a cofactor. SdhC is the cytochrome b558 subunit. It binds two hemes. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1821 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1821 ZOBELLIA_1822 ZOBELLIA_1822 sdhA sdhA 2138292 2140295 + Succinate dehydrogenase flavoprotein subunit Succinate dehydrogenase is a complex containing three subunits: a flavoprotein%2C an iron-sulfur protein and cytochrome b-558. It is involved in the citrate cycle and catalyzes the reaction: succinate + acceptor %3D fumarate + reduced acceptor. It uses a FAD as a cofactor. SdhA is the flavoprotein subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1822 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1822 ZOBELLIA_1823 ZOBELLIA_1823 sdhB sdhB 2140302 2141048 + Succinate dehydrogenase iron-sulfur subunit Succinate dehydrogenase is a complex containing three subunits: a flavoprotein%2C an iron-sulfur protein and cytochrome b-558. It is involved in the citrate cycle and catalyzes the reaction: succinate + acceptor %3D fumarate + reduced acceptor. It uses a FAD as a cofactor. SdhB is the iron-sulfur subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1823 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1823 ZOBELLIA_1824 ZOBELLIA_1824 vsrA vsrA 2141138 2141608 + Very short patch repair protein The Vsr (very short patch repair) proteins belong to a restriction-modification (R-M) system that recognise a TG mismatched base pair%2C generated after spontaneous deamination of methylated cytosines%2C and cleaves the phosphate backbone on the 5' side of the thymine. GT mismatches can lead to C-to-T transition mutations if not repaired. Vsr proteins repair the mismatches in favour of the G-containing strand%3B Belongs to the Vsr family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1824 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1824 ZOBELLIA_1825 ZOBELLIA_1825 ZOBELLIA_1825 2141700 2142245 + Intracellular peptidase%2C family C56 The catalytic diad of theses peptidases is constituted by two consecutive conserved residues%2C Cys His. The enzyme forms a hexameric ring structure%2C and the active site is proposed to be formed at the interface between three pairs of monomers%3B The peptidase monomer adopts a alpha/beta hydrolase fold%3B Belongs to the family 56 of the cysteine peptidases (C56)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1825 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1825 ZOBELLIA_1826 ZOBELLIA_1826 ZOBELLIA_1826 2142620 2145508 - Conserved hypothetical protein Conserved protein distantly related to glycoside hydrolases of the family 74 (GH74). Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space gene gene1826 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1826 ZOBELLIA_1827 ZOBELLIA_1827 pepP2 pepP2 2145868 2147181 + Xaa-Pro aminopeptidase%2C family M24 Xaa-Pro aminopeptidase catalyzes the release of any N-terminal amino acid%2C including proline%2C that is linked to proline%2C even from a dipeptide or tripeptide%3B PepP requires two co-catalytic ions of manganese%3B Belongs to the family 24 of the metallopeptidases (M24)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1827 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1827 ZOBELLIA_1828 ZOBELLIA_1828 xthA1 xthA1 2147191 2147961 + Exodeoxyribonuclease III The exonuclease III catalyses the cleavage in the 3'- to 5'-direction on double-stranded DNA to yield nucleoside 5'-phosphates. It also has an endonucleolytic activity near apurinic sites on DNA%3B Contains an Endonuclease/ Exonuclease/phosphatase domains%3B Belongs to the DNA repair enzymes AP family 1%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1828 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1828 ZOBELLIA_1829 ZOBELLIA_1829 ZOBELLIA_1829 2147965 2148138 + Putative protein Hypothetical protein gene gene1829 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1829 ZOBELLIA_183 ZOBELLIA_183 ZOBELLIA_183 213322 215040 + FAD-dependent oxidoreductase FAD-dependent oxidoreductase%2C Belongs to the GMC oxidoreductase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_183 ZOBELLIA_1830 ZOBELLIA_1830 aqpZ aqpZ 2148296 2148985 + Aquaporin Z Aquaporin Z is a channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity%3B Contains six transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1830 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1830 ZOBELLIA_1831 ZOBELLIA_1831 braB braB 2149029 2150315 - Branched chain amino acid transport system II carrier protein BraB is a component of the LIV-II transport system for branched-chain amino acids. It is specific for isoleucine%2C leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions%3B Contains twelve transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1831 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1831 ZOBELLIA_1832 ZOBELLIA_1832 ZOBELLIA_1832 2150359 2150490 + Putative protein Hypothetical protein gene gene1832 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1832 ZOBELLIA_1833 ZOBELLIA_1833 ZOBELLIA_1833 2150505 2150696 - Putative protein Hypothetical protein gene gene1833 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1833 ZOBELLIA_1834 ZOBELLIA_1834 ZOBELLIA_1834 2150737 2150913 + Conserved hypothetical protein Localized in the cytoplasm. gene gene1834 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1834 ZOBELLIA_1835 ZOBELLIA_1835 ZOBELLIA_1835 2151118 2152149 - Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Function unclear gene gene1835 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1835 ZOBELLIA_1836 ZOBELLIA_1836 thiL thiL 2152156 2153205 - Thiamine-monophosphate kinase Thiamine-monophosphate kinase is involved in the biosynthesis of thiaminine pyrophosphate (coenzyme B1)%2C an enzyme cofactor. It catalyzes the reaction: ATP + thiamine phosphate %3D ADP + thiamine diphosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1836 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1836 ZOBELLIA_1837 ZOBELLIA_1837 sufA sufA 2153544 2153879 + Protein SufA Protein SufA is a part of the suf operon (sufABCDSE). The six encoded proteins are arranged into two complexes (SufSE and SufBCD) and one protein . SufA acts as a scaffold protein in which Fe and S atoms are assembled into [FeS] cluster forms%2C which can then easily be transferred to apoproteins targets%3B The SUF system contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1837 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1837 ZOBELLIA_1838 ZOBELLIA_1838 sufB sufB 2153943 2155388 + Protein SufB The protein SufB is part of the SufBCD complex which acts synergistically with SufE to stimulate the cysteine desulfurase activity (SufS). The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1838 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1838 ZOBELLIA_1839 ZOBELLIA_1839 sufC sufC 2155437 2156189 + ATP-dependent transporter SufC SufC is an ATPase with an unorthodox ATP-binding cassette (ABC)-like component. It is part of the SufBCD complex which contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1839 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1839 ZOBELLIA_184 ZOBELLIA_184 ZOBELLIA_184 215047 215766 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 23 and 24%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_184 ZOBELLIA_1840 ZOBELLIA_1840 sufD sufD 2156263 2157579 + Protein SufD The protein SufD is part of the SufBCD complex which acts synergistically with sufE to stimulate the cysteine desulfurase activity (SufS). The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the fhuF protein%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1840 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1840 ZOBELLIA_1841 ZOBELLIA_1841 ZOBELLIA_1841 2157722 2158312 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1841 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1841 ZOBELLIA_1842 ZOBELLIA_1842 sufS sufS 2158392 2159606 + Cysteine desulfurase Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine%2C an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon%2C which is activated and required under specific conditions such as oxidative stress and iron limitation. SufS forms a homodimer and uses pyridoxal phosphate as a cofactor. It Interacts with SufE and the SufBCD complex. The interaction with SufE is required to mediate the direct transfer of the sulfur atom from the S-sulfanylcysteine%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1842 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1842 ZOBELLIA_1843 ZOBELLIA_1843 sufE sufE 2159681 2160103 + Cysteine desulfuration protein SufE The protein SufE is a component of the suf operon%2C which is activated and required under specific conditions such as oxidative stress and iron limitation. SufE is an homodimeric scaffold protein that accepts sulfur atom from the cysteine desulfurase SufS and donates it to SufA. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1843 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1843 ZOBELLIA_1844 ZOBELLIA_1844 ZOBELLIA_1844 2160158 2160487 + Conserved hypothetical protein Conserved protein belonging to the DUF59 family. Members of this family may all be components of ring hydroxylating complexes%3B Localized in the cytoplasm%3B~Family membership gene gene1844 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1844 ZOBELLIA_1845 ZOBELLIA_1845 ZOBELLIA_1845 2160497 2161003 + Conserved hypothetical protein Localized in the cytoplasm gene gene1845 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1845 ZOBELLIA_1846 ZOBELLIA_1846 ZOBELLIA_1846 2161070 2162002 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1846 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1846 ZOBELLIA_1847 ZOBELLIA_1847 ZOBELLIA_1847 2162189 2162404 - Putative protein Hypothetical protein gene gene1847 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1847 ZOBELLIA_1848 ZOBELLIA_1848 hfiX hfiX 2162899 2164110 - GTP-binding protein HflX GTPase of unknown function%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1848 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1848 ZOBELLIA_1849 ZOBELLIA_1849 ZOBELLIA_1849 2164187 2165161 + Endonuclease/exonuclease/phosphatase family The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling%3B Belongs to the Endonuclease/Exonuclease/phosphatase family%3B Localized in the cytoplasm%3B~Family membership gene gene1849 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1849 ZOBELLIA_185 ZOBELLIA_185 ZOBELLIA_185 215864 217075 - Conserved hypothetical protein Conserved hypothetical protein%3B Lipoprotein signal peptide cleaved between the residues 24 and 25%3B localized in the cytoplasmic or/and outer membrane gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_185 ZOBELLIA_1850 ZOBELLIA_1850 ZOBELLIA_1850 2165168 2165881 - Conserved hypothetical protein Localized in the cytoplasm gene gene1850 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1850 ZOBELLIA_1851 ZOBELLIA_1851 ZOBELLIA_1851 2166066 2166908 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 27 and 28%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1851 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1851 ZOBELLIA_1852 ZOBELLIA_1852 ogtA ogtA 2167086 2167559 - Methylated-DNA-[protein]-cysteine S-methyltransferase Methylated-DNA-[protein]-cysteine methyltransferase is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction since the enzyme is irreversibly inactivated and the methylated protein accumulates as a dead-end product%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1852 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1852 ZOBELLIA_1853 ZOBELLIA_1853 ZOBELLIA_1853 2167609 2168715 - CBS family protein This protein contains a N-terminal region containing four transmembrane helices (DUF21 family) and two C-terminal CBS (cystathionine-beta-synthase) domains. CBS domains are small intracellular modules that pair together to form a stable globular domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP%2C ATP and S-AdoMet. They may play a regulatory role making proteins sensitive to adenosyl carrying ligands%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1853 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1853 ZOBELLIA_1854 ZOBELLIA_1854 ZOBELLIA_1854 2168766 2170055 - Serine peptidase%2C family S12 Serine peptidase belonging to the family S12%2C which includes D-Ala-D-Ala carboxypeptidase B and aminopeptidase DmpB. The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa- Thr-Lys. Localized in the cytoplasm.%3B~Specificity unclear gene gene1854 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1854 ZOBELLIA_1855 ZOBELLIA_1855 hemB hemB 2170125 2171114 - Delta-aminolevulinic acid dehydratase Delta-aminolevulinic acid dehydratase catalyzes the second step in the biosynthesis of heme%2C the condensation of two molecules of 5-aminolevulinate to form porphobilinogen. The enzyme is an oligomer composed of eight identical subunits. Each of the subunits binds a zinc ion. A lysine has been implicated in the catalytic mechanism. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1855 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1855 ZOBELLIA_1856 ZOBELLIA_1856 ZOBELLIA_1856 2171187 2173829 + ATP-dependent helicase Helicases are involved in unwinding nucleic acids%3B Contains a N-terminal ResIII domain or a DEAD domain%2C in the central part%2C a C-terminal helicase domain and two C-terminal transmembrane segments%3B Belongs to the superfamily II of helicases%3B Localized in the membrane cytoplasmic%3B~Family membership gene gene1856 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1856 ZOBELLIA_1857 ZOBELLIA_1857 ZOBELLIA_1857 2173816 2174466 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 30 and 31%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1857 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1857 ZOBELLIA_1858 ZOBELLIA_1858 ZOBELLIA_1858 2174459 2174629 - Putative protein Hypothetical protein gene gene1858 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1858 ZOBELLIA_1859 ZOBELLIA_1859 hemF hemF 2174647 2175549 - Coproporphyrinogen-III oxidase Coproporphyrinogen-III oxidase catalyzes the sixth step in the heme biosynthesis pathway: coproporphyrinogen-III + O2 + 2 H+ %3D protoporphyrinogen-IX + 2 CO2 + 2 H2O. It forms a homodimer and binds one manganese as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1859 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1859 ZOBELLIA_186 ZOBELLIA_186 ZOBELLIA_186 217197 219137 - Conserved hypothetical membrane protein Contains a putaive lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_186 ZOBELLIA_1860 ZOBELLIA_1860 ZOBELLIA_1860 2175655 2176206 - Possible ribosomal protein N-acetyltransferase Could acetylate the N-terminal aminoacid of a ribosomal protein%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene1860 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1860 ZOBELLIA_1861 ZOBELLIA_1861 hemE hemE 2176220 2177254 - Uroporphyrinogen decarboxylase Uroporphyrinogen decarboxylase%2C the fifth enzyme of the heme biosynthetic pathway%2C catalyzes the sequential decarboxylation of the four acetyl side chains of uroporphyrinogen to yield coproporphyrinogen. It forms a homodimer. The monomer adopts a (beta/alpha)8-barrel fold with a deep active site cleft formed by loops at the C-terminal ends of the barrel strands. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1861 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1861 ZOBELLIA_1862 ZOBELLIA_1862 hemCD hemCD 2177316 2178902 - Porphobilinogen deaminase / Uroporphyrinogen-III synthase This protein is a bifunctional enzyme with a N-terminal porphobilinogen deaminase (HemC) and a C-terminal uroporphyrinogen-III synthase (hemD). Both activities are involved in porphyrin and heme biosynthesis. HemC catalyzes the tetrapolymerization of the monopyrrole porphobilinogen into the hydroxymethylbilane pre- uroporphyrinogen in several discrete steps. It binds one dipyrromethane group covalently%2C as a cofactor. HemD catalyzes the hydrolysis of hydroxymethylbilane into uroporphyrinogen III. Therefore this bifunctional enzyme forms uroporphyrinogen III from porphobilinogen. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1862 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1862 ZOBELLIA_1863 ZOBELLIA_1863 hemA hemA 2178899 2180155 - Glutamyl-tRNA-reductase Glutamyl-tRNA-reductase is involved in porphyrin biosynthesis. It reduces glutamyl-tRNA to glutamate-1-semialdehyde during the first stage of tetrapyrrole biosynthesis by the C5 pathway. This enzyme required NADPH as a coenzyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1863 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1863 ZOBELLIA_1864 ZOBELLIA_1864 ZOBELLIA_1864 2180361 2181254 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene1864 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1864 ZOBELLIA_1865 ZOBELLIA_1865 ZOBELLIA_1865 2181247 2181375 + Putative protein Hypothetical protein gene gene1865 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1865 ZOBELLIA_1866 ZOBELLIA_1866 ZOBELLIA_1866 2181420 2184227 + Conserved hypothetical protein The protein contains seven Fibronectin type 3 domains in its N-terminal part (42 to 713). No similarity with a known protein from the data bank was found with the 200 C-terminal residues%3B Signal peptide cleaved between the residues 23 and 24%3B Possible Lipoprotein localized in the outer membrane%3B~Function unclear gene gene1866 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1866 ZOBELLIA_1867 ZOBELLIA_1867 ZOBELLIA_1867 2184288 2184419 - Putative protein Hypothetical protein gene gene1867 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1867 ZOBELLIA_1868 ZOBELLIA_1868 ZOBELLIA_1868 2184419 2185264 - DUF1460 family protein Conserved protein belonging to the DUF1460 family. Features a signal peptide cleaved between the residues 19 and 20. Localized in the periplasm.%3B~Family membership gene gene1868 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1868 ZOBELLIA_1869 ZOBELLIA_1869 ZOBELLIA_1869 2185281 2188805 - Conserved hypothetical periplasmic protein Contains a N-terminal GumN domain (unknown function)%3B Signal peptide cleaved between the residues 17 and 18%3B Localized in the periplasmic space%3B~Family membership gene gene1869 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1869 ZOBELLIA_187 ZOBELLIA_187 ZOBELLIA_187 219196 220449 - Sugar permease The Sugar permeases belong to the major facilitator superfamily (MFS) transporters that are single-polypeptide secondary carriers capable only of transporting small solutes (probably sugars in this case) in response to chemiosmotic ion gradients%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_187 ZOBELLIA_1870 ZOBELLIA_1870 ZOBELLIA_1870 2188946 2190022 - Small-conductance mechanosensitive channel Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains four transmembrane helices%3B Belongs to the small- conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1870 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1870 ZOBELLIA_1871 ZOBELLIA_1871 hemH hemH 2190284 2191315 + Ferrochelatase Ferrochelatase catalyzes the last step in heme biosynthesis: the chelation of a ferrous ion to proto-porphyrin IX%2C to form protoheme. It contains a catalytic [Fe2S2] cluster. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1871 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1871 ZOBELLIA_1872 ZOBELLIA_1872 ZOBELLIA_1872 2191346 2192734 + Multi antimicrobial extrusion protein family Contains 12 transmembrane segments%3B Belongs to the multi antimicrobial extrusion (MATE) family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1872 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1872 ZOBELLIA_1873 ZOBELLIA_1873 ZOBELLIA_1873 2192767 2194095 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 30 and 31%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1873 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1873 ZOBELLIA_1874 ZOBELLIA_1874 ZOBELLIA_1874 2194155 2195051 - Conserved hypothetical membrane protein Contains one central transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1874 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1874 ZOBELLIA_1875 ZOBELLIA_1875 ZOBELLIA_1875 2195237 2195743 + Conserved hypothetical membrane protein Contains five transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1875 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1875 ZOBELLIA_1876 ZOBELLIA_1876 ZOBELLIA_1876 2195849 2197300 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains an HAMP domain and one transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1876 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1876 ZOBELLIA_1877 ZOBELLIA_1877 crtA crtA 2197362 2198141 + 3-hydroxybutyryl-CoA dehydratase Enzyme%2C also called crotonase%2C that participates to the fatty acid metabolism in the Butyrate/butanol-producing pathway.%3B~High confidence in function and specificity gene gene1877 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1877 ZOBELLIA_1878 ZOBELLIA_1878 ZOBELLIA_1878 2198177 2199727 + Putative exported protein Signal peptide cleaved between the rsidues 21 and 22%3B Probably localized in the periplasmic space%3B~Hypothetical protein gene gene1878 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1878 ZOBELLIA_1879 ZOBELLIA_1879 ZOBELLIA_1879 2199747 2200859 + Conserved hypothetical protein Cytoplasmic protein that contains a SAM domain gene gene1879 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1879 ZOBELLIA_188 ZOBELLIA_188 idnO1 idnO1 220474 221274 - Gluconate-5-dehydrogenase Also called 5-keto-D-gluconate 5-reductase%3B Involved in the nonphosphorylative%2C ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate using NADP as a coenzyme. Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_188 ZOBELLIA_1880 ZOBELLIA_1880 ZOBELLIA_1880 2200926 2201486 + Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 19 and 20%3B localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1880 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1880 ZOBELLIA_1881 ZOBELLIA_1881 ZOBELLIA_1881 2201581 2203005 - NAD(P)-dependent dehydrogenase%2C exported NAD(P)-dependent dehydrogenase. Belongs to the Rossmann fold family. Features a twin-arginine translocation signal peptide.%3B~Specificity unclear gene gene1881 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1881 ZOBELLIA_1882 ZOBELLIA_1882 ZOBELLIA_1882 2203081 2203773 - Metal-dependent phosphohydrolase In metal-dependent phosphohydrolase%2C divalent cations are coordinated by conserved histidines and aspartates%3B Belongs to the HD superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1882 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1882 ZOBELLIA_1883 ZOBELLIA_1883 plsC plsC 2203775 2204476 - 1-Acylglycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase is involved in the phospholipid biosynthesis (second step). It converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1883 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1883 ZOBELLIA_1884 ZOBELLIA_1884 ZOBELLIA_1884 2204602 2205012 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF1094 family%3B Localized in the cytoplasm gene gene1884 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1884 ZOBELLIA_1885 ZOBELLIA_1885 ZOBELLIA_1885 2205052 2205213 + Putative protein Hypothetical protein gene gene1885 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1885 ZOBELLIA_1886 ZOBELLIA_1886 djlA djlA 2205221 2205958 + Co-chaperone DjlA The protein DjlA is a Regulatory dnaK co-chaperone. Contains a N-terminal transmembrane helix and a C-terminal DnaJ domain%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1886 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1886 ZOBELLIA_1887 ZOBELLIA_1887 ZOBELLIA_1887 2206004 2206588 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1887 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1887 ZOBELLIA_1888 ZOBELLIA_1888 ZOBELLIA_1888 2206713 2207162 + Deoxycytidylate deaminase Deoxycytidylate deaminase converts deoxycytidine 5'-monophosphate (dCMP) to deoxyuridine 5'-monophosphate and is a major supplier of the substrate for thymidylate synthase%2C an important enzyme in DNA synthesis. It adopts an alpha/beta/alpha three-layered fold and forms a homohexamer. Binds two zinc ions by subunit. Belongs to the cytidine and deoxycytidylate deaminase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1888 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1888 ZOBELLIA_1889 ZOBELLIA_1889 ZOBELLIA_1889 2207166 2208791 + Carboxy-terminal processing peptidase%2C family S41 This enzyme is a modular protein with a N-terminal PDZ domain%2C a central carboxy-terminal processing peptidase and a C-terminal domain of unknown function. The catalytic module belongs to the family S41 of the peptidase. It shows specific recognition of a C-terminal tripeptide%2C Xaa-Yaa-Zaa%2C in which Xaa is preferably Ala or Leu%2C Yaa is preferably Ala or Tyr%2C and Zaa is preferably Ala%2C but then cleaves at a variable distance from the C- terminus. PDZ domains are multifunctional protein-protein interaction modules. In many cases%2C PDZ domains bind to a signature motif ([FYST]-X-[FVA]) occurring at the very C- terminus of target proteins. Features an uncleaved signal peptide.%3B~High confidence in function and specificity gene gene1889 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1889 ZOBELLIA_189 ZOBELLIA_189 kduI1 kduI1 221278 222123 - 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase is Involved in pectin degradation in pectinolytic microorganism%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_189 ZOBELLIA_1890 ZOBELLIA_1890 ZOBELLIA_1890 2208788 2209033 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1890 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1890 ZOBELLIA_1891 ZOBELLIA_1891 ZOBELLIA_1891 2209042 2209620 - Multiple antibiotic resistance related protein Members of this family are integral membrane proteins. These proteins may be transporters%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1891 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1891 ZOBELLIA_1892 ZOBELLIA_1892 ZOBELLIA_1892 2209742 2210314 + Conserved hypothetical protein Localized in the cytoplasm gene gene1892 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1892 ZOBELLIA_1893 ZOBELLIA_1893 ZOBELLIA_1893 2210304 2212280 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains seven N-terminal tetratrico peptide repeats (TPR)and two transmembrane segments and%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1893 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1893 ZOBELLIA_1894 ZOBELLIA_1894 ZOBELLIA_1894 2212287 2213021 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene1894 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1894 ZOBELLIA_1895 ZOBELLIA_1895 ZOBELLIA_1895 2213438 2213557 + Putative protein Hypothetical protein gene gene1895 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1895 ZOBELLIA_1896 ZOBELLIA_1896 ZOBELLIA_1896 2213563 2214156 + Conserved hypothetical protein Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane gene gene1896 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1896 ZOBELLIA_1897 ZOBELLIA_1897 ZOBELLIA_1897 2214603 2214815 - Putative protein Hypothetical protein gene gene1897 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1897 ZOBELLIA_1898 ZOBELLIA_1898 ZOBELLIA_1898 2214891 2215526 + Hypothetical periplasmic protein Contains a signal peptide cleaved between 21 and 22%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1898 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1898 ZOBELLIA_1899 ZOBELLIA_1899 ZOBELLIA_1899 2215585 2218422 + TPR repeats protein Protein containing three N-terminal tetratrico peptide repeats (TPRs) and a C-terminal conserved domain of unknown function. TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Contains a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1899 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1899 ZOBELLIA_19 ZOBELLIA_19 ZOBELLIA_19 18706 19389 - Conserved hypothetical protein Conserved hypothetical protein. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm. gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_19 ZOBELLIA_190 ZOBELLIA_190 ZOBELLIA_190 222131 223282 - Glycoside hydrolase%2C family GH105 This protein belongs to the family 105 of the glycoside hydrolases. These enzymes are involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. Asp104 is the putative catalytic residue (identical to Asp143 of the unsaturated rhamnogalacturonyl hydrolase from Bacillus subtilis%2C Itoh et al.%2C 2006%2C BBRC 347%2C 10211029). Features a signal peptide cleaved between residues 20 and 21. Localized in the periplasm.%3B~Specificity unclear gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_190 ZOBELLIA_1900 ZOBELLIA_1900 ZOBELLIA_1900 2218431 2219159 - Conserved hypothetical membrane protein Contains one central transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1900 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1900 ZOBELLIA_1901 ZOBELLIA_1901 ZOBELLIA_1901 2219152 2219706 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released. They alter the specificity of promoter recognition. This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1901 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1901 ZOBELLIA_1902 ZOBELLIA_1902 ZOBELLIA_1902 2219826 2221898 + Hypothetical lipoprotein Protein that could adopt a right handed parallel beta-helix fold%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene1902 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1902 ZOBELLIA_1903 ZOBELLIA_1903 ZOBELLIA_1903 2221950 2222297 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1903 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1903 ZOBELLIA_1904 ZOBELLIA_1904 ZOBELLIA_1904 2222368 2222952 + Conserved hypothetical protein Localized in the cytoplasm gene gene1904 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1904 ZOBELLIA_1905 ZOBELLIA_1905 ZOBELLIA_1905 2222986 2223351 + Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1905 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1905 ZOBELLIA_1906 ZOBELLIA_1906 ZOBELLIA_1906 2223412 2223528 - Putative protein Hypothetical protein gene gene1906 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1906 ZOBELLIA_1907 ZOBELLIA_1907 ZOBELLIA_1907 2223593 2223700 + Putative protein Hypothetical protein gene gene1907 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1907 ZOBELLIA_1908 ZOBELLIA_1908 ZOBELLIA_1908 2223718 2224200 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene1908 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1908 ZOBELLIA_1909 ZOBELLIA_1909 ZOBELLIA_1909 2224205 2226169 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1909 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1909 ZOBELLIA_191 ZOBELLIA_191 ZOBELLIA_191 223417 225111 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Probably localized in the cytoplasmic membrane%3B~Family membership gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_191 ZOBELLIA_1910 ZOBELLIA_1910 rnrB1 rnrB1 2226471 2227457 + Ribonucleoside-diphosphate reductase%2C small subunit Ribonucleoside-diphosphate reductase is an heterotetramer of two large and two small subunits. It catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O %3D ribonucleoside diphosphate + thioredoxin. This gene codes the small subunit. It binds two iron ions by subunit. This complex is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1910 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1910 ZOBELLIA_1911 ZOBELLIA_1911 rnrA1 rnrA1 2227580 2230066 + Ribonucleoside-diphosphate reductase%2C large subunit Ribonucleoside-diphosphate reductase is an heterotetramer of two large and two small subunits. It catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O %3D ribonucleoside diphosphate + thioredoxin. This gene codes the large subunit. This protein also features a N-terminal ATP cone domain%2C which is an evolutionarily mobile%2C ATP-binding regulatory domain. It binds either ATP (activating) or dATP (inhibitory). Substrate binding to the ATP cone domain is thought to alter the relative positions of the two subunits of Ribonucleoside-diphosphate reductase. This complex is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1911 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1911 ZOBELLIA_1912 ZOBELLIA_1912 ZOBELLIA_1912 2230484 2230624 - Putative protein Hypothetical protein gene gene1912 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1912 ZOBELLIA_1913 ZOBELLIA_1913 hyiA hyiA 2230876 2231853 - Hydroxypyruvate isomerase The Hydroxypyruvate isomerase catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)%3B Belongs to the xylose isomerase-like TIM barrel family%3B Exported by the twin-arginine translocation pathway signal%3B~High confidence in function and specificity gene gene1913 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1913 ZOBELLIA_1914 ZOBELLIA_1914 ZOBELLIA_1914 2231888 2232535 - Conserved hypothetical membrane protein Contains a putative putative lipoprotein signal peptide cleaved between the residues 29 and 30%3B Possibly localized in the cytoplasm or outer membrane%3B~Conserved hypothetical protein gene gene1914 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1914 ZOBELLIA_1915 ZOBELLIA_1915 ZOBELLIA_1915 2232535 2234247 - FAD-dependent oxidoreductase FAD-dependent oxidoreductase belonging to the GMC (glucose-methanol-choline) oxidoreductase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1915 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1915 ZOBELLIA_1916 ZOBELLIA_1916 ZOBELLIA_1916 2234388 2235383 + Conserved hypothetical membrane protein Belongs to the Xylose isomerase-like TIM barrel superfamily%3B Contains a putative lipoprotein signal peptide cleaved between the residues 24 and 25%2C Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1916 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1916 ZOBELLIA_1917 ZOBELLIA_1917 ZOBELLIA_1917 2235406 2235849 + Conserved hypothetical protein Localized in the cytoplasm gene gene1917 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1917 ZOBELLIA_1918 ZOBELLIA_1918 ZOBELLIA_1918 2235859 2237085 + Nucleoside/hydrogen symporter This integral membrane protein transports nucleosides with a high affinity. The transport mechanism is driven by proton motive force%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1918 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1918 ZOBELLIA_1919 ZOBELLIA_1919 ZOBELLIA_1919 2237171 2238310 + NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family%3B Adopts a Rossmann fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1919 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1919 ZOBELLIA_192 ZOBELLIA_192 ZOBELLIA_192 225122 228244 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (52-125) and the Plug module (141-255) acting as a channel gate%3B The signal peptide is cleaved between the residues 33 and 34%3B~Family membership gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_192 ZOBELLIA_1920 ZOBELLIA_1920 lacZ lacZ 2238406 2241618 - Beta-galactosidase%2C family GH2 Enzyme that catalyzes the hydrolysis of the beta- 1%2C 4 linkage at the terminal non-reducing of beta-D-galactosides%2C releasing a beta-D-galactose residue%3B Belongs to the family 2 of glycoside hydrolases (GH2)%3B Signal peptide cleaved between residues 28 and 29%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene1920 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1920 ZOBELLIA_1921 ZOBELLIA_1921 ZOBELLIA_1921 2241728 2242192 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF984 family%3B Localized in the cytoplasm gene gene1921 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1921 ZOBELLIA_1922 ZOBELLIA_1922 ZOBELLIA_1922 2242321 2244024 - FAD-dependent oxidoreductase%2C GMC oxidoreductase family FAD-dependent oxidoreductase%3B Belongs to the GMC oxidoreductase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1922 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1922 ZOBELLIA_1923 ZOBELLIA_1923 ZOBELLIA_1923 2244183 2245235 + TIM alpha/beta barrel protein This protein belongs to the xylose isomerase-like TIM barrel family%3B Adopts a TIM alpha/beta barrel fold%3B Localized in the cytoplasm%3B~Family membership gene gene1923 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1923 ZOBELLIA_1924 ZOBELLIA_1924 ZOBELLIA_1924 2245355 2246110 + Conserved hypothetical membrane protein Contains a domain of unknown function (DUF1080) that may adopt a concavalin-like or glucanase-like fold founded in glycoside hydrolases%3B Putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene1924 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1924 ZOBELLIA_1925 ZOBELLIA_1925 ZOBELLIA_1925 2246330 2247187 + Conserved hypothetical protein This conserved protein contains a N-terminal domain Localized in the cytoplasm%3B~Family membership gene gene1925 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1925 ZOBELLIA_1926 ZOBELLIA_1926 gmkA gmkA 2247215 2247799 + Guanylate kinase Guanylate kinase catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly%2C cGMP. There is an ATP-binding site (P-loop) in the N-terminal section of GmkA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1926 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1926 ZOBELLIA_1927 ZOBELLIA_1927 nadD nadD 2247832 2248416 + Nicotinate-nucleotide adenylyltransferase Nicotinate-nucleotide adenylyltransferase is involved in the NAD(P) biosynthesis pathway. NadD catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). It forms a homodimer and uses ATP as a cofactor. Belongs to the cytidylyltransferase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1927 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1927 ZOBELLIA_1928 ZOBELLIA_1928 ZOBELLIA_1928 2248418 2249539 - Amidohydrolase Protein belonging to the amidohydrolase family%2C metal-dependent hydrolase superfamily%3B Adopts a TIM-barrel fold%3B Localized in the cytoplasm%3B~Family membership gene gene1928 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1928 ZOBELLIA_1929 ZOBELLIA_1929 ZOBELLIA_1929 2249658 2250083 - Conserved hypothetical protein Localized in the cytoplasm gene gene1929 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1929 ZOBELLIA_193 ZOBELLIA_193 ZOBELLIA_193 228605 229540 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_193 ZOBELLIA_1930 ZOBELLIA_1930 ZOBELLIA_1930 2250181 2251125 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1930 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1930 ZOBELLIA_1931 ZOBELLIA_1931 ZOBELLIA_1931 2251238 2253487 - Phosphate transporter family protein This integral membrane protein is distantly related with phosphate-sodium symporter. Contains eleven transmembrane helices%3B Localized in the cytoplasmic memnbrane%3B~Family membership gene gene1931 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1931 ZOBELLIA_1932 ZOBELLIA_1932 ZOBELLIA_1932 2253859 2254218 + Conserved hypothetical periplasmic protein Contains three MORN repeat variants. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins. Signal peptide cleaved between the residues 21 and 22%3B Localized in periplasmic space%3B~Conserved hypothetical protein gene gene1932 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1932 ZOBELLIA_1933 ZOBELLIA_1933 ZOBELLIA_1933 2254294 2254686 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene1933 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1933 ZOBELLIA_1934 ZOBELLIA_1934 dgtA dgtA 2254848 2256191 + Deoxyguanosinetriphosphate triphosphohydrolase Deoxyguanosinetriphosphate triphosphohydrolase releases inorganic triphosphate%2C an unusual reaction product%2C from dGTP . Binds Mg2+ as a cofactor. The enzyme from Escherichia coli was shown to bind cooperatively to single stranded DNA. But the biological role of DgtA is still unknown. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1934 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1934 ZOBELLIA_1935 ZOBELLIA_1935 ZOBELLIA_1935 2256188 2257324 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene1935 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1935 ZOBELLIA_1936 ZOBELLIA_1936 dxsA dxsA 2257317 2259092 - 1-Deoxy-D-xylulose-5-phosphate synthase DsxA catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%2C a common precursor for isoprenoid%2C thiamin%2C and pyridoxol biosynthesis. It forms a homodimer and binds 1 thiamine pyrophosphate cofactor per subunit%3B Belongs to the transketolase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1936 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1936 ZOBELLIA_1937 ZOBELLIA_1937 tadA tadA 2259270 2259719 + tRNA-specific adenosine deaminase tRNA adenosine deaminase generates inosine by deaminating the adenosine residue at the wobble position of tRNAArg-2. This modification is essential for the decoding system. TadA has an alpha/beta/alpha three- layered fold and forms a homodimer%3B Binds%2C via three conserved histidine and cysteine residues%2C a catalytic zinc ion%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1937 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1937 ZOBELLIA_1938 ZOBELLIA_1938 cspA2 cspA2 2259800 2259994 - Cold shock protein Cold shock proteins (CSPs) help the cell to survive in temperatures lower than optimum growth temperature. CSPs may act as RNA chaperones by destabilizing RNA secondary structures%2C regulating ribosomal translation%2C rate of mRNA degradation and termination of transcription%3B Contains a 'cold-shock domain' (CSD) involved in the single-strand nucleic-acid binding%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1938 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1938 ZOBELLIA_1939 ZOBELLIA_1939 ZOBELLIA_1939 2260086 2260337 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1939 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1939 ZOBELLIA_194 ZOBELLIA_194 ZOBELLIA_194 229623 230822 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_194 ZOBELLIA_1940 ZOBELLIA_1940 ZOBELLIA_1940 2260382 2262166 - Voltage-gated chloride channel Chloride channels constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. Features eleven transmembrane helices. Localized in the cytoplasmic membrane. Also features a C-terminal CBS (cystathionine-beta-synthase) domain. In chloride ion channels%2C the CBS domains have been implicated in intracellular targeting and trafficking%2C as well as in protein-protein interactions%2C but results vary with different channels.%3B~High confidence in function and specificity gene gene1940 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1940 ZOBELLIA_1941 ZOBELLIA_1941 aspS aspS 2262226 2263980 - Aspartyl-tRNA synthetase The aminoacyl-tRNA synthetases catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. Aspartyl-tRNA synthetase catalyzes the reaction : ATP + L-aspartate + tRNA(Asp) %3D AMP + diphosphate + L-aspartyl-tRNA(Asp). AspS is an homodimer and is localized in the cytoplasm. It belongs to the class II of the aminoacyl-tRNA synthetases%2C which share an anti-parallel beta-sheet formation%2C flanked by alpha-helices.%3B~High confidence in function and specificity gene gene1941 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1941 ZOBELLIA_1942 ZOBELLIA_1942 ZOBELLIA_1942 2264170 2267172 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-99) and the Plug module (116-252) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~Family membership gene gene1942 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1942 ZOBELLIA_1943 ZOBELLIA_1943 ZOBELLIA_1943 2267183 2268514 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 27 and 28%3B Probably localized in the outer membrane%3B~Family membership gene gene1943 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1943 ZOBELLIA_1944 ZOBELLIA_1944 ZOBELLIA_1944 2268602 2272108 - Multidrug efflux transporter Integral membrane protein involved in drug resistance that belongs to the acrB/acrD/acrF family%3B Contains 14 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2%2C and helices 9 and 10. The three transmembrane domains form a large%2C 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1944 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1944 ZOBELLIA_1945 ZOBELLIA_1945 ZOBELLIA_1945 2272098 2273282 - Membrane fusion protein These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region%3B~Family membership gene gene1945 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1945 ZOBELLIA_1946 ZOBELLIA_1946 ZOBELLIA_1946 2273311 2274675 - Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Family membership gene gene1946 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1946 ZOBELLIA_1947 ZOBELLIA_1947 ZOBELLIA_1947 2274678 2275283 - TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene1947 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1947 ZOBELLIA_1948 ZOBELLIA_1948 ZOBELLIA_1948 2275360 2275791 - Conserved hypothetical protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane gene gene1948 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1948 ZOBELLIA_1949 ZOBELLIA_1949 ZOBELLIA_1949 2275810 2276349 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released. They alter the specificity of promoter recognition. This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B Belongs to the sigma-70 factor family%2C ECF subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1949 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1949 ZOBELLIA_195 ZOBELLIA_195 rraA1 rraA1 230829 231515 + Regulator of ribonuclease activity Regulator of ribonuclease activity is a general modulator of RNA abundance which inhibits the endonuclease activity of the RNase E and thereby leads to increase the half-life of RNAs%3B Contains a Demethylmenaquinone methyltransferase domain%3B Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_195 ZOBELLIA_1950 ZOBELLIA_1950 ZOBELLIA_1950 2276408 2276503 + Putative protein Hypothetical protein gene gene1950 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1950 ZOBELLIA_1951 ZOBELLIA_1951 idsA idsA 2276491 2277465 + Bifunctional short chain isoprenyl diphosphate synthase IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols%2C dolichols%2C ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits%2C typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopentenyl diphosphate per homodimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1951 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1951 ZOBELLIA_1952 ZOBELLIA_1952 crtY crtY 2277482 2278651 - Lycopene cyclase Catalyzes the double cyclization reaction which converts lycopene to beta-carotene%3B Involved in the carotenoid biosynthesis%3B contains a N-terminal transmembrane segment%3B Putatively localized in the cytoplasmic membrane%3B~Family membership gene gene1952 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1952 ZOBELLIA_1953 ZOBELLIA_1953 ZOBELLIA_1953 2278712 2280985 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (26-104) and the Plug module (121-228) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B Putatively involved in the colicin 1A and 1B uptake%3B~Family membership gene gene1953 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1953 ZOBELLIA_1954 ZOBELLIA_1954 ZOBELLIA_1954 2281066 2281722 + Transcriptional metalloregulator Metal dependent transcriptional regulator binds two divalent metal effectors per monomer via an dimerization domain with two metal-binding sites%2C upon which allosteric changes occur that moderate binding to the cognate DNA operators of a target gene via a N-terminal DtxR-type HTH domain%3B Contains an C-terminal SH3-like domain that characterizes the Fe(II)-regulators. It may act to stabilizing the dimeric form of the repressor%3B~Family membership gene gene1954 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1954 ZOBELLIA_1955 ZOBELLIA_1955 zupT zupT 2281724 2282545 + Heavy-metal cations permease Mediates zinc uptake. May also transport other divalent cations%3B Contains three N-terminal and three C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1955 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1955 ZOBELLIA_1956 ZOBELLIA_1956 ZOBELLIA_1956 2282750 2283979 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains an N- terminal GAF domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene1956 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1956 ZOBELLIA_1957 ZOBELLIA_1957 ZOBELLIA_1957 2284009 2286642 - Conserved hypothetical protein Contains a C-terminal domain displaying some similarities with sequences of the family 63 of glycoside hydrolases (Mannosyl-oligosaccharide glucosidase)%3B Probably localized in the cytoplasm gene gene1957 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1957 ZOBELLIA_1958 ZOBELLIA_1958 ZOBELLIA_1958 2286767 2286877 - Putative protein Hypothetical protein gene gene1958 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1958 ZOBELLIA_1959 ZOBELLIA_1959 ZOBELLIA_1959 2286898 2287329 + Hypothetical membrane protein Contains one transmembrane segment%3B Probably localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene1959 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1959 ZOBELLIA_196 ZOBELLIA_196 ZOBELLIA_196 231679 233847 + Glycoside hydrolase%2C family GH31 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. This enzyme belongs to the family 31 of the glycoside hydrolases (GH 31)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Specificity unclear gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_196 ZOBELLIA_1960 ZOBELLIA_1960 ZOBELLIA_1960 2287450 2287818 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene1960 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1960 ZOBELLIA_1961 ZOBELLIA_1961 ZOBELLIA_1961 2287967 2288302 + Conserved hypothetical membrane protein Contains three transmenbrane segments%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the cytoplasmic membrnane%3B~Conserved hypothetical protein gene gene1961 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1961 ZOBELLIA_1962 ZOBELLIA_1962 ZOBELLIA_1962 2288299 2289843 - Hypothetical protein Contains an N-terminal carboxypeptidase regulatory domain%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space gene gene1962 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1962 ZOBELLIA_1963 ZOBELLIA_1963 ZOBELLIA_1963 2289978 2290127 - Conserved hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1963 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1963 ZOBELLIA_1964 ZOBELLIA_1964 feoB feoB 2290129 2292366 - Ferrous iron transport protein B The FeoB protein is an integral membrane protein that belongs to the GTP-driven ferrous iron uptake system. The protein possesses an N-terminal 300 amino acyl residue hydrophilic domain that bears at its N-terminus a GTP binding motif that shows slow GTP hydrolysis. Binding of GTP is required for an efficient ferrous iron uptake. Nevertheless%2C GTP hydrolysis is essential for Fe2+ transport%3B Contains 8 C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene1964 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1964 ZOBELLIA_1965 ZOBELLIA_1965 feoA feoA 2292363 2292608 - Ferrous iron transport protein A FeoA is involved in ferrous iron (Fe2+)uptake in bacteria%2C but its exact function is still unknown. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1965 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1965 ZOBELLIA_1966 ZOBELLIA_1966 ZOBELLIA_1966 2292784 2293461 - Conserved hypothetical membrane protein Protein that consists of a SCO1/SenC domain%3B Contains a N-terminal transmembrane segment%3B Belongs to the SCO2/SenC family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene1966 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1966 ZOBELLIA_1967 ZOBELLIA_1967 ecfE ecfE 2293641 2294999 + Peptidase EcfE%2C family M50 Peptidase EcfE degrades both heat shock sigma factors RpoE and RpoH in vitro. Features a N-terminal catalytic module belonging to the family 50 of the metallopeptidases followed by a PDZ module. Family M50 peptidases contain an HEXXH motif %3B the glutamate has a catalytic role and the two histidines are ligands of a zinc ion. There is a more C-terminal Asp (in an invariant Asp-Gly motif) that is required for activity and is predicted to be a third ligand. Features four transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene1967 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1967 ZOBELLIA_1969 ZOBELLIA_1969 ZOBELLIA_1969 2295248 2296234 - Transposase%2C family 12 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 12 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene1969 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1969 ZOBELLIA_197 ZOBELLIA_197 fucA10 fucA10 233887 235503 + Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 24 and 25%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_197 ZOBELLIA_1970 ZOBELLIA_1970 ZOBELLIA_1970 2296221 2296574 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene1970 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1970 ZOBELLIA_1971 ZOBELLIA_1971 ZOBELLIA_1971 2296935 2297177 + Putative protein Hypothetical protein gene gene1971 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1971 ZOBELLIA_1972 ZOBELLIA_1972 ZOBELLIA_1972 2297520 2298404 - Conserved hypothetical protein Localized in the cytoplasm gene gene1972 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1972 ZOBELLIA_1973 ZOBELLIA_1973 cgiA3 cgiA3 2298513 2299502 - Iota-carrageenase%2C family GH82 The Iota-carrageenases hydrolyse the 1%2C4-beta-D-galactosidic linkages in the iota-carrgeenan giving the tetramer as the predominant product%3B Belongs to the family 82 of glycoside hydrolases (GH82)%3B This enzyme could to be localized in the outer membrane%3B~High confidence in function and specificity gene gene1973 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1973 ZOBELLIA_1974 ZOBELLIA_1974 ZOBELLIA_1974 2299948 2300136 - Putative protein Hypothetical protein gene gene1974 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1974 ZOBELLIA_1975 ZOBELLIA_1975 ZOBELLIA_1975 2300251 2301075 + Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains two copies of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS- box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene1975 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1975 ZOBELLIA_1976 ZOBELLIA_1976 pckA1 pckA1 2301254 2302888 + Phosphoenolpyruvate carboxykinase [ATP] Phosphoenolpyruvate carboxykinase (ATP) (PEPCK) catalyzes the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate while hydrolyzing ATP%2C a rate limiting step in gluconeogenesis. PEPCK is allosterically activated by calcium and positively regulated by cAMP. It is involved in the glyoxylate bypass%2C an alternative to the tricarboxylic acid cycle%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene1976 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1976 ZOBELLIA_1977 ZOBELLIA_1977 ZOBELLIA_1977 2302961 2303068 + Putative protein Hypothetical protein gene gene1977 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1977 ZOBELLIA_1978 ZOBELLIA_1978 ZOBELLIA_1978 2303561 2304952 + Exopolysaccharide production protein Conserved protein involved in exopolysaccharide biosynthesis. Its exact function is unknown. Contains five transmembrane helices. Localized in the cytoplasmic membrane.%3B~Function unclear gene gene1978 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1978 ZOBELLIA_1979 ZOBELLIA_1979 ZOBELLIA_1979 2305062 2305823 + Polysaccharide export protein Membrane protein likely involved in the export of expolysaccharide repeating units from the cytoplasm into the periplasm in a process analogous to O-unit export%3B Contains a C-terminal transmembrane helix%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1979 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1979 ZOBELLIA_198 ZOBELLIA_198 ZOBELLIA_198 235697 235930 + Putative protein Hypothetical protein gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_198 ZOBELLIA_1980 ZOBELLIA_1980 wzcA wzcA 2305926 2308331 + Tyrosine-protein kinase May be involved in the production and the transport of exopolysaccharides%3B Contains a N-terminal transmembrane segment%3B Belongs to the etk/wzc family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1980 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1980 ZOBELLIA_1981 ZOBELLIA_1981 ZOBELLIA_1981 2308374 2309741 + Conserved hypothetical membrane protein Contains eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene1981 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1981 ZOBELLIA_1982 ZOBELLIA_1982 rfbX rfbX 2309760 2311121 + O-antigen transporter May be involved in the Lipopolysaccharide O antigen biosynthesis%2C translocating the nascent polysaccharidic O-antigen molecules and/or ligating them to lipid A core units%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene1982 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1982 ZOBELLIA_1983 ZOBELLIA_1983 ZOBELLIA_1983 2311169 2312200 + Conserved hypothetical protein Contains a domain of unknown function DUF354. This family mainly contains proteins from Archae%3B Localized in the cytoplasm gene gene1983 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1983 ZOBELLIA_1984 ZOBELLIA_1984 algD algD 2312228 2313532 + GDP-mannose 6-dehydrogenase GDP-mannose 6-dehydrogenase catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid . In Pseudomonas aeruginosa%2C this activated sugar is the precursor for alginate polymerization. AlgD belongs to the UDP-glucose/GDP- mannose dehydrogenase family%2C a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1984 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1984 ZOBELLIA_1985 ZOBELLIA_1985 ZOBELLIA_1985 2313625 2314725 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene1985 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1985 ZOBELLIA_1986 ZOBELLIA_1986 ZOBELLIA_1986 2314969 2316159 + Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene1986 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1986 ZOBELLIA_1987 ZOBELLIA_1987 ZOBELLIA_1987 2316263 2317198 + Conserved hypothetical protein Localized in the cytoplasm gene gene1987 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1987 ZOBELLIA_1988 ZOBELLIA_1988 ZOBELLIA_1988 2317267 2318364 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 4 of the glycosyltransferases (GT4)%3B Localized in the cytoplasm.%3B~Specificity unclear gene gene1988 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1988 ZOBELLIA_1989 ZOBELLIA_1989 ZOBELLIA_1989 2318361 2320268 - Polysaccharide lyase%2C family PL12 Polysaccharide lyase catalyses the eliminative cleavage of polysaccharides containing uronic acids. Belongs to the family 12 of the polysaccharide lyases. Up to now%2C the only known activity in family PL12 is heparin-sulfate lyase (EC 4.2.2.8). Localized in the cytoplasm.%3B~Specificity unclear gene gene1989 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1989 ZOBELLIA_199 ZOBELLIA_199 ZOBELLIA_199 235945 237537 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~Family membership gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_199 ZOBELLIA_1990 ZOBELLIA_1990 ZOBELLIA_1990 2320733 2321779 + Conserved hypothetical lipoprotein Lipoprotein signal peptide cleaved between the residues 26 and 27%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1990 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1990 ZOBELLIA_1991 ZOBELLIA_1991 ZOBELLIA_1991 2322036 2325008 + Conserved hypothetical lipoprotein Lipoprotein that contains%2C in its central part%2C four PKD domains. These domains are putatively involved in the protein-protein or proteins-polysaccharide interactions%3B Signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene1991 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1991 ZOBELLIA_1992 ZOBELLIA_1992 ZOBELLIA_1992 2325091 2326407 - Conserved hypothetical protein Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane gene gene1992 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1992 ZOBELLIA_1993 ZOBELLIA_1993 ZOBELLIA_1993 2326400 2327479 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 2 of the glycosyltransferases (GT2)%3B Contains two transmembrane helices in C-terminus%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1993 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1993 ZOBELLIA_1994 ZOBELLIA_1994 ZOBELLIA_1994 2327649 2328614 - Carbohydrate esterase%2C family CE4 The carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides. These proteins fold into a 7-stranded beta/alpha barrel%3B Contains a C-terminal transmembrane helix%3B Belongs to the family 4 of carbohydrate esterases (CE4)%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene1994 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1994 ZOBELLIA_1995 ZOBELLIA_1995 ZOBELLIA_1995 2328647 2329951 - FAD-dependent amine oxidoreductase The main role of amine oxidases is to provide a source of ammonium%3B Adopts a Rossmann fold%3B Uses FAD as prosthetic group%3B Localized in the cytoplasm%3B~Specificity unclear gene gene1995 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1995 ZOBELLIA_1996 ZOBELLIA_1996 ZOBELLIA_1996 2329948 2330952 - NAD(P)-dependent sugar epimerase/dehydratase Conserved protein belonging to the NAD(P)-dependent sugar epimerase/dehydratase family%2C which is included in the Rossmann fold superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene1996 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1996 ZOBELLIA_1997 ZOBELLIA_1997 ZOBELLIA_1997 2331349 2332026 + NUDIX hydrolase The generic name 'NUDIX hydrolases' corresponds to pyrophosphatases cleaving a NUcleoside DIphosphate linked to some other moiety X. These enzymes hydrolyze diverse nucleoside diphosphate derivatives (including ADP-ribose%2C GDP- mannose%2C TDP-glucose%2C NADH%2C UDP-sugars%2C dNTP and NTP). Localized in the cytoplasm.%3B~Specificity unclear gene gene1997 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1997 ZOBELLIA_1998 ZOBELLIA_1998 araB araB 2332126 2333820 + Ribulokinase Ribulokinase catalyzes the phosphorylation of ribulose . This is the second step of the arabinose catabolism. AraB belongs to the FGGY family of the carbohydrate kinases.%3B~High confidence in function and specificity gene gene1998 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1998 ZOBELLIA_1999 ZOBELLIA_1999 araD araD 2333813 2334517 + L-ribulose-5-phosphate 4-epimerase L-ribulose-5-phosphate 4-epimerase catalyzes the conversion of L-ribulose 5-phosphate into D-xylulose 5-phosphate. This is the third step of the L-arabinose catabolism. AraD belongs to the class II aldolase family. Binds one zinc ion by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene1999 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_1999 ZOBELLIA_2 ZOBELLIA_2 ZOBELLIA_2 2030 2755 + Methyltransferases Enzyme that uses S-AdoMet in the methylation of diverse substrates%3B Belongs to the UPF0011 family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2 ZOBELLIA_20 ZOBELLIA_20 ZOBELLIA_20 19492 20580 + Metallopeptidase%2C family M42 Peptidase family M42 contains metalloaminopeptidases some of which also have acylaminoacylpeptidase activity. These peptidases are co- catalytic metallopeptidases%2C typically binding two atoms of zinc or cobalt. Metal ligands occur in the sequence: H%2C D%2C E%2C D/E%2C H%3B and active site residues in the motifs HXD and EE. Localized in the cytoplasm.%3B~Specificity unclear gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_20 ZOBELLIA_200 ZOBELLIA_200 ZOBELLIA_200 237537 240674 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (Here%2C possibly sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (58-134) and the Plug module (148-255) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~Family membership gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_200 ZOBELLIA_2000 ZOBELLIA_2000 sglT sglT 2334542 2336107 + Sodium/glucose symporter SglT Actively transports glucose into cells by Na(+) cotransport. Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of pro- and eukaryotic cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient is used to drive solute accumulation against a concentration gradient. Features fourteen transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2000 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2000 ZOBELLIA_2001 ZOBELLIA_2001 araA araA 2336131 2337633 + L-arabinose isomerase L-arabinose isomerase catalyzes the conversion of L-arabinose into L-ribulose. This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2001 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2001 ZOBELLIA_2002 ZOBELLIA_2002 ZOBELLIA_2002 2337642 2338832 - Conserved hypothetical protein Contains a central transmembrane helix%3B Localized in the cytoplasmic membrane gene gene2002 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2002 ZOBELLIA_2003 ZOBELLIA_2003 ZOBELLIA_2003 2338948 2342181 + Cytochrome c-containing protein This protein has a modular architecture with a N-terminal cytochrome C (residues 19-136) and three domains of unknown function: a DUF1549 domain which includes a second cytochrome C (161-395)%2C a central domain adopting a jelly roll fold (concavalin A-like%2C 449-666) and a C-terminal DUF1553 domain (762-1077). Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic and/or outer membrane%3B~Function unclear gene gene2003 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2003 ZOBELLIA_2004 ZOBELLIA_2004 ZOBELLIA_2004 2342191 2343669 + Conserved hypothetical periplasmic protein Contains a domain of unknown function DUF1501%3B Belongs to the alkaline-phosphatase clan%3B Contains a twin-arginine signal peptide%3B Localized in the periplasmic space%3B~Family membership gene gene2004 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2004 ZOBELLIA_2005 ZOBELLIA_2005 ZOBELLIA_2005 2343675 2344742 + Hypothetical periplasmic protein This protein likely adopts a beta-propeller fold%3B Contains a twin-arginine signal peptide%3B Localized in the periplasmic space%3B~Family membership gene gene2005 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2005 ZOBELLIA_2006 ZOBELLIA_2006 ZOBELLIA_2006 2344805 2345398 + Endoribonuclease L-PSP Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. This protein may also be involved in the regulation of purine biosynthesis%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2006 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2006 ZOBELLIA_2007 ZOBELLIA_2007 ZOBELLIA_2007 2345402 2346412 + TRAP transporter%2C substrate-binding periplasmic subunit The substrate-binding periplasmic subunit is a extracytoplasmic solute receptor%2C a component of a tripartite ATP-independent periplasmic (TRAP) transport system. The two other components of the system are two transmembrane proteins. TRAP transporters are secondary carriers that use an electrochemical H+ gradient as the driving force for transport%3B Contains a lipoprotein signal peptide cleaved between the residues 26 and 27%3B Anchored in the cytoplasmic membrane%2C in periplasmic side%3B~Specificity unclear gene gene2007 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2007 ZOBELLIA_2008 ZOBELLIA_2008 ZOBELLIA_2008 2346402 2346866 + TRAP transporter%2C small permease subunit The small permease subunit is a component of a tripartite ATP-independent periplasmic (TRAP) transport system. The two other components of the system are a second transmembrane proteins and a extracytoplasmic solute receptor. TRAP transporters are secondary carriers that use an electrochemical H+ gradient as the driving force for transport%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2008 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2008 ZOBELLIA_2009 ZOBELLIA_2009 ZOBELLIA_2009 2346863 2348137 + TRAP transporter%2C large permease subunit The large permease subunit is a component of a tripartite ATP-independent periplasmic (TRAP) transport system. The two other components of the system are a second transmembrane proteins and a extracytoplasmic solute receptor. TRAP transporters are secondary carriers that use an electrochemical H+ gradient as the driving force for transport%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2009 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2009 ZOBELLIA_201 ZOBELLIA_201 ZOBELLIA_201 241120 242964 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a N-terminal transmembrane segment followed by two periplasmic tetratrico peptide repeats (TPRs) and a C-terminal cytoplasmic AraC-type HTH domain. The TPR repeats and the AraC-type HTH domain are separated by a second transmembrane segment. TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Localized in the cytoplasmic membrane.%3B~Function unclear gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_201 ZOBELLIA_2010 ZOBELLIA_2010 ZOBELLIA_2010 2348149 2348967 + Esterase Putative esterase. Adopts an alpha/beta hydrolase fold%3B Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2010 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2010 ZOBELLIA_2012 ZOBELLIA_2012 ZOBELLIA_2012 2349206 2349313 - Putative protein Hypothetical protein gene gene2012 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2012 ZOBELLIA_2013 ZOBELLIA_2013 ZOBELLIA_2013 2349481 2350173 - Conserved hypothetical protein Localized in the cytoplasm gene gene2013 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2013 ZOBELLIA_2014 ZOBELLIA_2014 speA speA 2350657 2352114 + Arginine decarboxylase Arginine decarboxylase catalyzes the biosynthesis of agmatine from arginine. It is involved in the putrescine biosynthesis pathway. Uses the pyridoxal- phosphate as prosthetic group linked to a conserved lysine residue%3B Binds a magnesium ion%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2014 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2014 ZOBELLIA_2015 ZOBELLIA_2015 speB speB 2352130 2353071 + Agmatinase Agmatinase hydrolyses agmatine to putrescine%2C the precursor for the biosynthesis of higher polyamines%2C spermidine and spermine%3B Adopts a 3-layer alpha-beta-alpha fold%3B Binds a manganese ion%3B Belongs to the arginase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2015 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2015 ZOBELLIA_2016 ZOBELLIA_2016 ZOBELLIA_2016 2353058 2354035 + Deoxyhypusine synthase-like protein Deoxyhypusine synthase transfers alkyl or aryl groups on an acceptor molecule. It likely catalyzes the NAD(+)-dependent dehydrogenation of spermidine%2C resulting in the formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue. The 4-aminobutylidene group is then transfered from the enzyme intermediate to an acceptor molecule%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2016 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2016 ZOBELLIA_2017 ZOBELLIA_2017 ZOBELLIA_2017 2354032 2354358 + Conserved hypothetical protein Localized in the cytoplasm gene gene2017 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2017 ZOBELLIA_2018 ZOBELLIA_2018 ZOBELLIA_2018 2354473 2356002 + N-acetyltransferase / Carbon-Nitrogen hydrolase Modular protein composed of a N-terminal N-acetyltransferase domain of the GNAT family (residues 2-224) and a C-terminal Carbon-Nitrogen hydrolase domain (225-508). The Gcn5-related N-acetyltransferases (GNAT) catalyze the transfer of the acetyl from the Coenzyme A donor to a primary amine of an acceptor. The carbon-nitrogen hydrolase domain is involved in the reduction of organic nitrogen compounds and ammonia production%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2018 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2018 ZOBELLIA_2019 ZOBELLIA_2019 rimK2 rimK2 2356004 2357374 + Ribosomal protein S6 modification protein RimK is responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6. This protein forms a dimer%3B Binds one ATP and 2 manganese ions by subunit%3B Contains a N-terminal domain of unknown function (DUF785)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2019 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2019 ZOBELLIA_202 ZOBELLIA_202 ZOBELLIA_202 242961 243503 - Conserved hypothetical protein Localized in the cytoplasm gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_202 ZOBELLIA_2020 ZOBELLIA_2020 ZOBELLIA_2020 2357431 2357556 - Putative protein Hypothetical protein gene gene2020 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2020 ZOBELLIA_2021 ZOBELLIA_2021 ZOBELLIA_2021 2357868 2358362 + SCP-like extracellular protein SCP-like extracellular proteins have been proposed to be a calcium ion chelating serine proteases. The Calcium-chelating function would fit with the various signalling processes where these proteins are involved and also the structural evidence of a conserved pocket containing two histidines and a glutamate%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Function unclear gene gene2021 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2021 ZOBELLIA_2022 ZOBELLIA_2022 ZOBELLIA_2022 2358691 2361714 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2022 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2022 ZOBELLIA_2023 ZOBELLIA_2023 ZOBELLIA_2023 2361756 2362679 + Conserved hypothetical protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane gene gene2023 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2023 ZOBELLIA_2024 ZOBELLIA_2024 ZOBELLIA_2024 2362692 2364644 + OmpA-like outer membrane protein This protein has a modular architecture composed of a N-terminal TPR motif%2C a central beta-propeller domain%2C encompassing three WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan. The tetratrico peptide repeat (TPR) is a structural motif%2C which mediates proteinprotein interactions%3B Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Function unclear gene gene2024 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2024 ZOBELLIA_2025 ZOBELLIA_2025 ZOBELLIA_2025 2364745 2365686 - NAD-dependent epimerase/dehydratase This enzyme belongs to the NAD-dependent epimerase/dehydratase family%2C which is included in the Rossmann fold Superfamily. In this family%2C the proteins use nucleotide-sugar substrates for a variety of chemical reactions%3B Localized in the cytoplasm%3B~Family membership gene gene2025 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2025 ZOBELLIA_2026 ZOBELLIA_2026 ZOBELLIA_2026 2365751 2366245 + Conserved hypothetical protein Containsan uncleaved signal sequence%3B Localized in the cytoplasmic membrane gene gene2026 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2026 ZOBELLIA_2027 ZOBELLIA_2027 ZOBELLIA_2027 2366310 2367611 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2027 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2027 ZOBELLIA_2028 ZOBELLIA_2028 ZOBELLIA_2028 2367762 2368466 - Conserved hypothetical protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space gene gene2028 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2028 ZOBELLIA_2029 ZOBELLIA_2029 ZOBELLIA_2029 2368619 2369017 - Conserved hypothetical protein Localized in the cytoplasm gene gene2029 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2029 ZOBELLIA_203 ZOBELLIA_203 ZOBELLIA_203 243507 243617 + Putative protein Hypothetical protein gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_203 ZOBELLIA_2030 ZOBELLIA_2030 ZOBELLIA_2030 2369108 2369911 - Conserved hypothetical protein Likely contains a NAD(P) binding protein%3B Localized in the cytoplasm gene gene2030 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2030 ZOBELLIA_2031 ZOBELLIA_2031 ZOBELLIA_2031 2369904 2372189 - Metallopeptidase%2C family M28 These peptidases have co-catalytic zinc ions. Each zinc ion is tetrahedrally co-ordinated%2C with three amino acid ligands plus activated water. Two catalytic motifs are conserved: His-Xaa-Asp and Glu-Glu. Contains 8 transmembrane helices. Belongs to the M28 family of peptidases%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2031 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2031 ZOBELLIA_2032 ZOBELLIA_2032 ZOBELLIA_2032 2372395 2372862 + CBS domain protein CBS domains are small intracellular modules that pair together to form a stable globular domain. They have been shown to bind ligands with an adenosyl group such as AMP%2C ATP and S-AdoMet%3B Localized in the cytoplasm%3B~Family membership gene gene2032 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2032 ZOBELLIA_2033 ZOBELLIA_2033 ZOBELLIA_2033 2372956 2373306 - Conserved hypothetical protein Localized in the cytoplasm gene gene2033 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2033 ZOBELLIA_2034 ZOBELLIA_2034 ZOBELLIA_2034 2373308 2373799 - Conserved hypothetical protein Contains a signal peptide cleaved between residues 17 and 18%3B Localized in the periplasmic space gene gene2034 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2034 ZOBELLIA_2035 ZOBELLIA_2035 mcbG mcbG 2373861 2374436 - Protein mcbG Together with two other proteins%2C mcbE and mcbF%2C this protein causes immunity to the peptide antibiotic microcin%2C which inhibits DNA replication by induction of the SOS repair system. McbG alone can provide some protection%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2035 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2035 ZOBELLIA_2036 ZOBELLIA_2036 ZOBELLIA_2036 2374515 2374727 - Conserved hypothetical protein Localized in the cytoplasm gene gene2036 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2036 ZOBELLIA_2037 ZOBELLIA_2037 ZOBELLIA_2037 2374738 2374860 + Putative protein Hypothetical protein gene gene2037 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2037 ZOBELLIA_2038 ZOBELLIA_2038 ZOBELLIA_2038 2375004 2378048 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (33-106) and the Plug module (122-228) acting as a channel gate%3B The signal peptide is cleaved between the residues 31 and 32%3B~Family membership gene gene2038 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2038 ZOBELLIA_2039 ZOBELLIA_2039 ZOBELLIA_2039 2378059 2379708 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Family membership gene gene2039 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2039 ZOBELLIA_204 ZOBELLIA_204 ZOBELLIA_204 243610 243732 - Putative protein Hypothetical protein gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_204 ZOBELLIA_2040 ZOBELLIA_2040 cmlA cmlA 2379799 2380425 - Chloramphenicol O-acetyltransferase Chloramphenicol O-acetyltransferase is an effector of chloramphenicol resistance in bacteria. It converts the chloramphenicol to chloramphenicol 3-acetate%3B Forms a homotrimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2040 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2040 ZOBELLIA_2041 ZOBELLIA_2041 ZOBELLIA_2041 2380623 2381240 + Conserved hypothetical lipoprotein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG)%3B Signal peptide of lipoprotein cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Function unclear gene gene2041 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2041 ZOBELLIA_2042 ZOBELLIA_2042 ZOBELLIA_2042 2381279 2381749 - Conserved hypothetical protein Localized in the cytoplasm gene gene2042 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2042 ZOBELLIA_2043 ZOBELLIA_2043 ZOBELLIA_2043 2381809 2382324 - Hypothetical periplasmic protein Contains a putative signal peptide cleaved between residues 27 and 28%3B Putatively localized in the periplasmic space%3B~Hypothetical protein gene gene2043 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2043 ZOBELLIA_2044 ZOBELLIA_2044 ZOBELLIA_2044 2382541 2383110 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2044 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2044 ZOBELLIA_2045 ZOBELLIA_2045 ZOBELLIA_2045 2383421 2383822 - Hypothetical membrane protein Contains one transmembrane helix (residues 78-100)%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2045 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2045 ZOBELLIA_2046 ZOBELLIA_2046 ZOBELLIA_2046 2383906 2384697 - Hypothetical protein Putatively localized in the cytoplasm. gene gene2046 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2046 ZOBELLIA_2047 ZOBELLIA_2047 ZOBELLIA_2047 2384887 2385396 - Hypothetical protein Putatively localized in the cytoplasm. gene gene2047 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2047 ZOBELLIA_2048 ZOBELLIA_2048 ssb2 ssb2 2385617 2385949 + Single-stranded DNA-binding protein Single-stranded DNA-binding protein (SSB) is essential for replication of the chromosome. It is also involved in DNA recombination and repair. This protein forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2048 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2048 ZOBELLIA_2049 ZOBELLIA_2049 recQ1 recQ1 2386061 2388160 + ATP-dependent DNA helicase RecQ RecQ is a ATP-dependent DNA helicase involved in genome maintenance in the RecF recombination pathway%3B RecQ unwinds paired DNA%2C translocating in a 3' to 5' direction%3B The expression of RecQ gene is under the regulation of the SOS system. Contains a DEAD/H box and a HRDC domain%3B Belongs to superfamily II of helicases%2C RecQ family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2049 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2049 ZOBELLIA_205 ZOBELLIA_205 ZOBELLIA_205 244031 245296 - Conserved hypothetical protein Contains a C-terminal domain of unknown function (100 aa) and a lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_205 ZOBELLIA_2050 ZOBELLIA_2050 paaK paaK 2388193 2389482 - Phenylacetate-coenzyme A ligase Phenylacetate-coenzyme A ligase catalyzes the activation of phenylacetic acid to phenylacetyl-CoA. It is the first step of the Phenylacetic acid aerobic catabolism%3B Also acts%2C more slowly%2C on acetate%2C propanoate and butanoate%2C but not on hydroxy derivatives of phenylacetate and related compounds%3B Activated by cAMP receptor protein (CRP)%3B Contains an AMP binding motif%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2050 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2050 ZOBELLIA_2051 ZOBELLIA_2051 ZOBELLIA_2051 2389483 2391159 - Cysteine endopeptidase%2C family C45 Peptidase family C45 contains autolytic endopeptidases. The active site cysteine becomes the new N-terminus following the autolytic cleavage. Features a C-terminal TPR domain. Signal peptide of lipoprotein cleaved between the residues 21 and 22. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene2051 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2051 ZOBELLIA_2052 ZOBELLIA_2052 ZOBELLIA_2052 2391209 2392090 - Conserved hypothetical protein Putative transcription factor that contains a JmjC domain (jumonji family of transcription factors). JmJC domains are predicted to be metalloenzymes that adopt the cupin fold%3B Localized in the cytoplasm gene gene2052 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2052 ZOBELLIA_2053 ZOBELLIA_2053 ZOBELLIA_2053 2392090 2393637 - Flavin containing amine oxidoreductase Flavin containing amine oxidoreductase which contains a N-terminal DAO (D-amino acid oxidase) domain and one tranmembrane segment%3B Use FAD as cofactor%3B Belongs to the carotenoid/retinoid oxidoreductase family%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene2053 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2053 ZOBELLIA_2054 ZOBELLIA_2054 ZOBELLIA_2054 2393637 2397323 - Exporter / acyltransferase This protein encompasses a N-terminal conserved domain predicted to be an exporter containing 13 transmembrane helices (residues 1-809) and a C-terminal catalytic domain belonging to the phospholipid/glycerol acyltransferase family (810-1228)%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene2054 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2054 ZOBELLIA_2055 ZOBELLIA_2055 ZOBELLIA_2055 2397316 2398518 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases.%2C Features four transmembrane helices in C-terminus. Localized in the cytoplasmic membrane.%2C%3B~Specificity unclear gene gene2055 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2055 ZOBELLIA_2056 ZOBELLIA_2056 ZOBELLIA_2056 2398578 2399081 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 17 and 18%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2056 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2056 ZOBELLIA_2057 ZOBELLIA_2057 fabZ1 fabZ1 2399087 2399455 - (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (FabZ) catalyses the dehydratation of beta-hydroxyacyl-ACP generated by FabG to trans-2-enoyl-ACP. This is the third step of the fatty acid elongation cycle. FabZ forms a hexamer (a trimer of dimers) where the monomer adopts a beta + alpha \\hotdog\\ fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2057 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2057 ZOBELLIA_2058 ZOBELLIA_2058 ZOBELLIA_2058 2399461 2400048 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2058 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2058 ZOBELLIA_2059 ZOBELLIA_2059 ZOBELLIA_2059 2400045 2400656 - Conserved hypotetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2059 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2059 ZOBELLIA_206 ZOBELLIA_206 ZOBELLIA_206 245329 247131 - Sulfatase%2C family S1-17 Modular protein consisting of a C-terminal domain of unknown function (DUF814) and a N-terminal domain belonging to the family 1 of sulfatases. The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Family membership gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_206 ZOBELLIA_2060 ZOBELLIA_2060 lolA lolA 2400637 2401254 - Outer-membrane lipoprotein carrier protein LolA is a molecular chaperone that participates in the translocation of lipoproteins from the cytoplasmic membrane to the outer membrane. LolA forms a complex with lipoproteins that do not possess an aspartate residue after the N-terminal Cys residue%3B Contains a signal peptide cleaved between residues 17 and 18%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2060 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2060 ZOBELLIA_2061 ZOBELLIA_2061 pgdA pgdA 2401247 2402023 - Peptidoglycan N-acetylglucosamine deacetylase%2C family CE4 The peptidoglycan N-acetylglucosamine deacetylase hydrolyzes the acetyl group of N-acetylglucosamine in peptidoglycans%3B Belongs to the family 4 of carbohydrate esterases (CE4) and fold into a 7-stranded beta/alpha barrel%3B Contains two N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2061 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2061 ZOBELLIA_2062 ZOBELLIA_2062 fabF fabF 2402017 2403081 - 3-oxoacyl-[acyl-carrier-protein] synthase II 3-oxoacyl-[acyl-carrier-protein] synthase II%2C also known as beta-ketoacyl synthase II%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. FabF Has a preference for short chain acid substrates%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2062 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2062 ZOBELLIA_2063 ZOBELLIA_2063 fabB3 fabB3 2403081 2404283 - 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2063 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2063 ZOBELLIA_2064 ZOBELLIA_2064 acpP2 acpP2 2404406 2404663 - Acyl carrier protein Acyl carrier protein (ACP) is the carrier of the growing fatty acid chain in fatty acid biosynthesis. ACP is produced as an apoprotein and is converted to its active form by [ACP]synthase (AcpS)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2064 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2064 ZOBELLIA_2065 ZOBELLIA_2065 ZOBELLIA_2065 2404660 2405268 - Conserved hypothetical protein Localized in the cytoplasm gene gene2065 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2065 ZOBELLIA_2066 ZOBELLIA_2066 fabB4 fabB4 2405265 2406413 - 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2066 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2066 ZOBELLIA_2067 ZOBELLIA_2067 ybgC1 ybgC1 2406406 2406843 - Acyl-CoA thioester hydrolase Acyl-CoA thioester hydrolase is involved in fatty acid biosynthesis catalyzing the hydrolysis of the thioester bond in acyl-CoA to give the corresponding fatty acid and CoA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2067 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2067 ZOBELLIA_2068 ZOBELLIA_2068 ZOBELLIA_2068 2406833 2408101 - ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2068 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2068 ZOBELLIA_2069 ZOBELLIA_2069 ZOBELLIA_2069 2408094 2408837 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene2069 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2069 ZOBELLIA_207 ZOBELLIA_207 ZOBELLIA_207 247342 248979 + Conserved hypothetical membrane protein Contains one N-terminal transmembrane segment%2C then four N-terminal tetratricopeptide repeats (TPR)%2C and a C-terminal LuxR-type HTH domain. The TPRs and the HTH domains are separated by a second transmembrane segment%3B This Protein could interact with the DNA (transcriptional control or transcription factor)%3B localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_207 ZOBELLIA_2070 ZOBELLIA_2070 ZOBELLIA_2070 2408912 2409907 - Conserved hypothetical protein Localized in the cytoplasm gene gene2070 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2070 ZOBELLIA_2071 ZOBELLIA_2071 ZOBELLIA_2071 2409916 2410314 - Conserved hypothetical protein Localized in the cytoplasm gene gene2071 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2071 ZOBELLIA_2072 ZOBELLIA_2072 ZOBELLIA_2072 2410351 2410749 - Conserved hypothetical protein Conserved hypothetical protein distantly related to (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (FabZ)%3B Localized in the cytoplasm gene gene2072 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2072 ZOBELLIA_2073 ZOBELLIA_2073 fabZ2 fabZ2 2410805 2411242 - (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (FabZ) catalyses the dehydratation of beta-hydroxyacyl-ACP generated by FabG to trans-2-enoyl-ACP. This is the third step of the fatty acid elongation cycle. FabZ forms a hexamer (a trimer of dimers) where the monomer adopts a beta + alpha \\hotdog\\ fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2073 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2073 ZOBELLIA_2074 ZOBELLIA_2074 darB darB 2411244 2412377 - 3-oxoacyl-[acyl-carrier-protein] synthase III DarB is homologous to 3-oxoacyl-[acyl-carrier-protein] synthase III%2C also known as beta-ketoacyl-ACP synthase III (FabH)%2C which catalyses the first condensation step within the fatty acid synthesis pathway converting the Acyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein]%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2074 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2074 ZOBELLIA_2075 ZOBELLIA_2075 darA darA 2412387 2413310 - Dialkylrecorsinol condensing enzyme DarA catalyzes the head-to-head condensation of two beta-ketoacyl thioester intermediates (fatty acid-derived precursors) forming a dioxocyclohexene intermediate%3B Contains a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2075 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2075 ZOBELLIA_2076 ZOBELLIA_2076 ZOBELLIA_2076 2413382 2414269 - Acyltransferase Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2076 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2076 ZOBELLIA_2077 ZOBELLIA_2077 acpP3 acpP3 2414293 2414541 - Acyl carrier protein Acyl carrier protein (ACP) is the carrier of the growing fatty acid chain in fatty acid biosynthesis. ACP is produced as an apoprotein and is converted to its active form by [ACP]synthase (AcpS)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2077 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2077 ZOBELLIA_2078 ZOBELLIA_2078 fabB5 fabB5 2414548 2415765 - 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2078 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2078 ZOBELLIA_2079 ZOBELLIA_2079 fabG2 fabG2 2415783 2416538 - 3-oxoacyl-[acyl-carrier protein] reductase FabG catalyzes the first reduction step of the fatty acid biosynthesis pathway. Belongs to the short- chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2079 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2079 ZOBELLIA_208 ZOBELLIA_208 engA engA 249036 250229 - Endoglucanase%2C family GH5 Endoglucanase catalyzes the endohydrolysis of the 1%2C 4-beta-D-glucosidic linkages in lichenan%2C cereal beta-D-glucans and carboxymethyl-cellulose and the 1%2C4-beta-D-xylosidic linkages in xylans. This enzyme is highly%3B~Specificity unclear gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_208 ZOBELLIA_2080 ZOBELLIA_2080 ZOBELLIA_2080 2416648 2417775 - KGW repeats protein This conserved hypothetical protein contains KGW repeats%3B Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2080 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2080 ZOBELLIA_2081 ZOBELLIA_2081 hutH hutH 2417772 2419310 - Histidine ammonia-lyase Histidine ammonia-lyase converts L-histidine to urocanate and ammonia. This is the first step of the histidine degradation pathway. The active site is 4-methylidene-imidazol-5-one (MIO)%2C which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2081 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2081 ZOBELLIA_2082 ZOBELLIA_2082 ZOBELLIA_2082 2419519 2420775 + Aromatic-ring hydroxylase%2C FAD-dependent oxidoreductase family Aromatic-ring hydroxylases (or monooxygenases) catalyze the incorporation of one atom of dioxygen into an aromatic compound and the reduction of the other oxygen atom to water. These oxidoreductases are FAD-dependent and adopt a Rossmann fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2082 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2082 ZOBELLIA_2083 ZOBELLIA_2083 ZOBELLIA_2083 2421111 2422124 + GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA. At the C-terminus there is an effector- binding/oligomerisation domain%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2083 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2083 ZOBELLIA_2084 ZOBELLIA_2084 ZOBELLIA_2084 2422503 2425598 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (33-106) and the Plug module (122-244) acting as a channel gate. The signal peptide is cleaved between the residues 31 and 32.%3B~Family membership gene gene2084 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2084 ZOBELLIA_2085 ZOBELLIA_2085 ZOBELLIA_2085 2425638 2427164 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 16 and 17%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B it is possible that this protein be localized in both membranes%3B~Family membership gene gene2085 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2085 ZOBELLIA_2086 ZOBELLIA_2086 ZOBELLIA_2086 2427279 2430815 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins. The FG-GAP repeat has been predicted to fold into a beta propeller structure. The FG- GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B Contains a signal peptide of lipoprotein cleaved between the residues 24 and 25%3B Protein putatively localized in the cytoplasmic membrane%3B~Function unclear gene gene2086 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2086 ZOBELLIA_2087 ZOBELLIA_2087 ZOBELLIA_2087 2430812 2434321 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins%3B The FG-GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B The FG-GAP repeat has been predicted to fold into a beta propeller structure%3B Contains a signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Protein putatively localized in the cytoplasmic membrane%3B~Function unclear gene gene2087 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2087 ZOBELLIA_2088 ZOBELLIA_2088 ZOBELLIA_2088 2434305 2435630 + Vanadium-dependent haloperoxidase Vanadium-dependent Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide%2C which results in subsequent halogenation of organic substrates%2C or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products%2C such as volatile halogenated hydrocarbons%2C chiral halogenated terpenes%2C acetogenins and indoles%3B Lipoprotein signal peptide cleaved between the residues 17 and 18%3B localized in the outer membrane%3B~Specificity unclear gene gene2088 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2088 ZOBELLIA_2089 ZOBELLIA_2089 ZOBELLIA_2089 2436080 2437852 + (Trans)glycosidase superfamily protein This conserved protein belongs to the (Trans)glycosidase superfamily%2C which is included in the TIM beta/alpha-barrel fold. Distantly related to the glycoside hydrolases 36 (GH36)%3B Localized in the cytoplasm%3B~Family membership gene gene2089 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2089 ZOBELLIA_209 ZOBELLIA_209 ZOBELLIA_209 250450 252039 - Hypothetical lipoprotein Lipoprotein that probably is involved in the sugar metabolism (possibly the polygalactoses or related sugars)%3B Contains a C-terminal carbohydrate binding module of the family 4 (CBM4)%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the outer membrane%3B~Hypothetical protein gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_209 ZOBELLIA_2090 ZOBELLIA_2090 maaA1 maaA1 2437860 2438420 + Maltose O-acetyltransferase Maltose O-acetyltransferase converts the maltose to acetyl-maltose from acetyl-CoA. Maltose O-acetyltransferase is a homodimer%2C responsible for exit of maltose and glucose in their acetylated forms%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2090 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2090 ZOBELLIA_2091 ZOBELLIA_2091 ZOBELLIA_2091 2438464 2440113 + Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2091 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2091 ZOBELLIA_2092 ZOBELLIA_2092 ZOBELLIA_2092 2440125 2440958 - Acid phosphatase/vanadium-dependent haloperoxidase family protein This enzyme belongs to the Acid phosphatase / vanadium-dependent haloperoxidase family protein%3B Features a signal peptide cleaved between residues 18 and 19%3B Localized in the periplasmic space%3B~Family membership gene gene2092 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2092 ZOBELLIA_2093 ZOBELLIA_2093 ZOBELLIA_2093 2441137 2442039 - Deacetylase%2C histone deacetylase family Deacetylase. Belongs to the histone deacetylase family.%3B~Specificity unclear gene gene2093 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2093 ZOBELLIA_2094 ZOBELLIA_2094 ZOBELLIA_2094 2442183 2442344 + Putative protein Hypothetical protein gene gene2094 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2094 ZOBELLIA_2095 ZOBELLIA_2095 ZOBELLIA_2095 2442376 2442528 + Putative protein Hypothetical protein gene gene2095 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2095 ZOBELLIA_2096 ZOBELLIA_2096 texA texA 2442554 2444677 - Transcriptional accessory protein Tex The protein Tex is a transcriptional accessory protein%2C but its exact function is not known. Contains a central RNAse H-like domain and a C-terminal S1 RNA binding domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2096 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2096 ZOBELLIA_2097 ZOBELLIA_2097 metG metG 2444742 2446820 - Methionyl-tRNA synthetase%2C class Ia Methionyl-tRNA synthetase catalyzes the attachment of methionine to its cognate transfer RNA molecule (tRNA(Met)) in a highly specific two-step reaction. MetG is required not only for elongation of protein synthesis but also for the initiationof translation of all mRNA through initiator tRNA(fMet) aminoacylation. MetG is a homodimer that binds one zinc ion per subunit%3B Contains a C-terminal tRNA binding domain%3B Belongs to the Class Ia aminoacyl-tRNA synthetases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2097 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2097 ZOBELLIA_2098 ZOBELLIA_2098 ZOBELLIA_2098 2446956 2447054 + Putative protein Hypothetical protein gene gene2098 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2098 ZOBELLIA_2099 ZOBELLIA_2099 ZOBELLIA_2099 2447090 2448799 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF1501 family%3B Contains a twin-arginine translocation signal peptide%3B Localized in the periplasmic space gene gene2099 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2099 ZOBELLIA_21 ZOBELLIA_21 ZOBELLIA_21 20627 21175 + NUDIX hydrolase Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties%2C X. They require Mg2+ or Mn2+%2C for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates%2C dinucleoside polyphosphates%2C nucleotide-sugars and dinucleotide enzymes. In general%2C the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability%2C thereby serving as surveillance %26 \\house- cleaning\\ enzymes%3B Belong to the Nudix hydrolase superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_21 ZOBELLIA_210 ZOBELLIA_210 ZOBELLIA_210 252049 253074 - Hypothetical lipoprotein Signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Hypothetical protein gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_210 ZOBELLIA_2100 ZOBELLIA_2100 ZOBELLIA_2100 2448811 2450304 - Conserved hypothetical protein Localized in the cytoplasm gene gene2100 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2100 ZOBELLIA_2101 ZOBELLIA_2101 ZOBELLIA_2101 2450500 2450859 + Conserved hypothetical protein Conserved hypothetical protein belonging to the UPF0102 family. localized in the cytoplasm gene gene2101 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2101 ZOBELLIA_2102 ZOBELLIA_2102 ZOBELLIA_2102 2450975 2451670 + Conserved hypothetical protein Localized in the cytoplasm gene gene2102 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2102 ZOBELLIA_2103 ZOBELLIA_2103 ZOBELLIA_2103 2451676 2452995 - Thiol-disulfide oxidoreductase Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Contains a N-terminal domain of unknown function and a C-terminal Thiol-disulfide oxidoreductase domain%3B Belongs to the thioredoxin family%3B Signal peptide cleaved between residues 18 and 19%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2103 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2103 ZOBELLIA_2104 ZOBELLIA_2104 aehA aehA 2453048 2454973 - Alpha-amino acid ester hydrolase%2C family S15 alpha-Amino acid ester hydrolases (AEHs) catalyze the hydrolysis and synthesis of esters and amides with an alpha-amino group. They can synthesize beta-lactam antibiotics from acyl compounds and beta-lactam nuclei obtained from the hydrolysis of natural antibiotics. Belongs to the family S15 of the peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 14 and 15%3B Localized in the outer membrane%3B~Specificity unclear gene gene2104 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2104 ZOBELLIA_2105 ZOBELLIA_2105 axeA axeA 2455026 2456318 - Acetyl xylan esterase%2C family CE7 Acetyl xylan esterase catalyzes the hydrolysis of acetyl groups of xylan%3B Contains a signal peptide cleaved between the residues 21 and 22%3B Belongs to the family 7 of carbohydrate esterases (CE7)%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2105 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2105 ZOBELLIA_2106 ZOBELLIA_2106 mfdA mfdA 2456405 2459809 - Transcription-repair coupling factor The transcription-repair coupling factor (TRCF) acts as an ATP-dependent helicase that is necessary for strand-specific repair. A lesion in the template strand blocks the RNA polymerase (RNAP). The RNAP-DNA-RNA complex is specifically recognized by TRCF which releases RNAP and the unfinished transcript. The TCRF may replace RNAP at the lesion site and then recruit the UvrABC repair system%3B Belongs to the superfamily 2 of helicases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2106 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2106 ZOBELLIA_2107 ZOBELLIA_2107 gorA gorA 2460105 2461454 + Glutathione reductase Glutathione reductase maintains high levels of reduced glutathione in the cytosol%3B Its active site is a redox-active disulfide bond%3B Glutathione reductase is a homodimer which binds 1 NADP and 1 FAD per subunit%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2107 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2107 ZOBELLIA_2108 ZOBELLIA_2108 ZOBELLIA_2108 2461471 2462271 - Conserved hypothetical membrane protein Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2108 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2108 ZOBELLIA_2109 ZOBELLIA_2109 ZOBELLIA_2109 2462343 2462930 - Metallo-phosphoesterase family The metallo-phosphoesterase motif is found in a large number of proteins invoved in phosphoryation. These include serine/threonine phosphatases%2C DNA polymerase%2C exonucleases%2C and other phosphatases%3B Localized in the cytoplasm%3B~Family membership gene gene2109 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2109 ZOBELLIA_211 ZOBELLIA_211 ZOBELLIA_211 253138 254865 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane%3B~Family membership gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_211 ZOBELLIA_2110 ZOBELLIA_2110 ZOBELLIA_2110 2463108 2467448 - Endonuclease / exonuclease / phosphatase family protein Endonuclease/exonuclease/phosphatase family protein%3B Contains an OB-fold nucleic acid binding domain and an endonuclease/phosphatase domain%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Family membership gene gene2110 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2110 ZOBELLIA_2111 ZOBELLIA_2111 ZOBELLIA_2111 2467794 2468234 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene2111 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2111 ZOBELLIA_2112 ZOBELLIA_2112 ZOBELLIA_2112 2468323 2470791 - Uncharacterized ATP-dependent helicase Contains the motif DExD/H found in ATP-dependent helicases as well as a number of hypothetical proteins together with the helicase conserved C-terminal domain%3B Belongs to the helicase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2112 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2112 ZOBELLIA_2113 ZOBELLIA_2113 ligC ligC 2470799 2472463 - DNA ligase DNA ligase (polydeoxyribonucleotide synthase) joins two DNA fragments by catalysing the formation of an internucleotide phosphodiester bond between 5-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using ATP as a coenzyme and as the energy source. It is essential for DNA replication%2C DNA recombination and DNA repair%3B Belongs to the ATP-dependent DNA ligase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2113 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2113 ZOBELLIA_2114 ZOBELLIA_2114 ZOBELLIA_2114 2472460 2473500 - Metallo-beta-lactamase superfamily protein Protein belonging to the zinc-dependent beta-lactamase superfamily. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2114 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2114 ZOBELLIA_2115 ZOBELLIA_2115 ZOBELLIA_2115 2473642 2474064 + Conserved hypothetical protein Localized in the cytoplasm gene gene2115 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2115 ZOBELLIA_2116 ZOBELLIA_2116 fbpA fbpA 2474117 2475127 - Fructose-1%2C6-bisphosphatase Fructose-1%2C6-bisphosphatase is involved in glycolysis / gluconeogenesis and in mannose and fructose metabolism. It removes one phosphate group from D-fructose 1%2C6-bisphosphate to form D-fructose 6-phosphate. The catalytic mechanism of FbpA is dependent of Mg2+%3B Belongs to the inositol polyphosphate 1 phosphatase like superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2116 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2116 ZOBELLIA_2117 ZOBELLIA_2117 ZOBELLIA_2117 2475244 2475723 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene2117 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2117 ZOBELLIA_2118 ZOBELLIA_2118 ZOBELLIA_2118 2475733 2476068 + Conserved hypothetical protein Localized in the cytoplasm gene gene2118 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2118 ZOBELLIA_2119 ZOBELLIA_2119 lysC lysC 2476113 2477363 + Aspartate kinase III Aspartate kinase III is involved in L-Lysine biosynthesis pathways. It converts L-aspartate to 4-phospho-L-aspartate%3B Belongs to the Amino acid kinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2119 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2119 ZOBELLIA_212 ZOBELLIA_212 ZOBELLIA_212 254885 257734 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a Plug module (60-151) acting as a channel gate%3B The signal peptide is cleaved between the residues 26 and 27%3B~Family membership gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_212 ZOBELLIA_2120 ZOBELLIA_2120 ZOBELLIA_2120 2477453 2479264 + Phospholipid/glycerol Acyltransferase / hemolysin fusion Contains an N-terminal Phospholipid/glycerol Acyltransferase domain and a C-terminal hemolysin domain%3B Localized in the cytoplasm%3B~Family membership gene gene2120 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2120 ZOBELLIA_2121 ZOBELLIA_2121 ZOBELLIA_2121 2479281 2479781 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene2121 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2121 ZOBELLIA_2122 ZOBELLIA_2122 ZOBELLIA_2122 2479807 2480205 - Conserved hypothetical protein Contains two transmembrane segments%3B Localized in the cytoplasmic membrane gene gene2122 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2122 ZOBELLIA_2123 ZOBELLIA_2123 ZOBELLIA_2123 2480368 2480835 - Conserved hypothetical protein Localized in the cytoplasm gene gene2123 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2123 ZOBELLIA_2124 ZOBELLIA_2124 ZOBELLIA_2124 2480835 2481206 - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Protein belonging to the Glyoxalase (lactoylglutathione lyase) superfamily protein%3B Localized in the cytoplasm%3B~Family membership gene gene2124 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2124 ZOBELLIA_2125 ZOBELLIA_2125 ZOBELLIA_2125 2481290 2482270 - D-isomer specific 2-hydroxyacid dehydrogenase NAD-dependent 2-hydroxyacid dehydrogenase which seems to be specific for the D-isomer of their substrate%3B Contains a NAD-binding domain%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2125 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2125 ZOBELLIA_2126 ZOBELLIA_2126 ZOBELLIA_2126 2482450 2483802 - Divalent cation transporter Divalent cation transporter belonging to the MgtE family%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2126 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2126 ZOBELLIA_2127 ZOBELLIA_2127 ksgA ksgA 2483972 2484835 - 16S rRNA adenine dimethyltransferase The 16S rRNA adenine dimethyltransferase specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2127 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2127 ZOBELLIA_2128 ZOBELLIA_2128 ZOBELLIA_2128 2484845 2485147 - Conserved hypothetical protein Localized in the cytoplasm gene gene2128 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2128 ZOBELLIA_2129 ZOBELLIA_2129 ZOBELLIA_2129 2485167 2485478 - Conserved hypothetical protein Localized in the cytoplasm gene gene2129 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2129 ZOBELLIA_213 ZOBELLIA_213 ZOBELLIA_213 257772 259580 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane%3B~Family membership gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_213 ZOBELLIA_2130 ZOBELLIA_2130 ZOBELLIA_2130 2485488 2487152 - Carboxy-terminal processing peptidase%2C family S41 Modular protein with a N-terminal domain of unknown function%2C a central PDZ domain involved in protein-protein interaction and C-terminal processing peptidase. The catalytic module shows specific recognition for a C-terminal tripeptide%2C Ala/Leu-Ala/Tyr-Ala%2C but then cleaves at a variable distance from the C-terminus%3B belongs to the family 41 of the serine peptidases (S41)%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasm%3B~High confidence in function and specificity gene gene2130 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2130 ZOBELLIA_2131 ZOBELLIA_2131 ZOBELLIA_2131 2487187 2488971 - TPR repeats protein Protein containing six tetratrico peptide repeats (TPR). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Function unclear gene gene2131 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2131 ZOBELLIA_2132 ZOBELLIA_2132 ZOBELLIA_2132 2489177 2489488 + Putative protein Hypothetical protein gene gene2132 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2132 ZOBELLIA_2133 ZOBELLIA_2133 serS serS 2489545 2490816 - Seryl-tRNA synthetase%2C class IIa Seryl-tRNA synthetase is responsible for the attachment of serine to the 3' OH group of ribose of its cognate transfer RNA molecule (tRNA(Ser)) in a highly specific two-step reaction. It is a homodimer%3B Belongs to the class-IIa aminoacyl-tRNA synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2133 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2133 ZOBELLIA_2134 ZOBELLIA_2134 ZOBELLIA_2134 2490896 2491273 + Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Protein belonging to the Glyoxalase superfamily protein (lactoylglutathione lyase)%3B Localized in the cytoplasm%3B~Family membership gene gene2134 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2134 ZOBELLIA_2135 ZOBELLIA_2135 ggcX ggcX 2491260 2492600 - Vitamin K-dependent gamma-glutamyl carboxylase Vitamin K-dependent gamma-glutamyl carboxylase is involved in the Vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues in various proteins. It converts glutamate residues to gamma-carboxyglutamate%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2135 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2135 ZOBELLIA_2136 ZOBELLIA_2136 ribF ribF 2492601 2493527 - Riboflavin biosynthesis protein RibF Riboflavin biosynthesis protein RibF is a protein that includes a Riboflavin kinase activity and a FMN adenylyltransferase activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2136 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2136 ZOBELLIA_2137 ZOBELLIA_2137 ZOBELLIA_2137 2493580 2497365 + Metalloendopeptidase%2C family M12 Endopeptidase Containing a large C-terminal region%2C encompassing a fibronectin type 3 domain and a proprotein convertase P-domain necessary for folding and maintaining the endopeptidase catalytic domain and to regulate its calcium and acidic pH dependence%3B Belongs to the family 12 of the metallopeptidases (M12)%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2137 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2137 ZOBELLIA_2138 ZOBELLIA_2138 ZOBELLIA_2138 2497362 2498042 + Fibronectin type-III repeats protein Protein that contains two type-III fibronectin (FN3) domains. Structures of individual FN3 domains have revealed a conserved beta sandwich fold also found in bacterial glycosyde hydrolases and other proteins%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Function unclear gene gene2138 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2138 ZOBELLIA_2139 ZOBELLIA_2139 pthA pthA 2498029 2498658 - Peptidyl-tRNA hydrolase Peptidyl-tRNA hydrolase hyrolyzes the N-substituted aminoacyl-tRNA to N-substituted amino acid and tRNA. The natural substrate for this enzyme may be the peptidyl-tRNAs which drop off the ribosome during protein synthesis%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2139 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2139 ZOBELLIA_214 ZOBELLIA_214 ZOBELLIA_214 259592 262690 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-99) and the Plug module (115-223) acting as a channel gate%3B The signal peptide is cleaved between the residues 17 and 18%3B~Family membership gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_214 ZOBELLIA_2140 ZOBELLIA_2140 rplY rplY 2498779 2499408 - Ribosomal protein L25 Ribosomal protein L25 is a part of the large ribosomal subunit (50S). This is one of the proteins that binds to the 5S rRNA where it forms part of the central protuberance. It binds to the 5S rRNA independently of L5 and L18. Not required for binding of the 5S rRNA/L5/L18 subcomplex to 23S rRNA%3B Belongs to the ribosomal protein L25p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2140 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2140 ZOBELLIA_2141 ZOBELLIA_2141 prsA prsA 2499455 2500396 - Ribose-phosphate pyrophosphokinase Ribose-phosphate pyrophosphokinase converts the D-ribose 5-phosphate to 5-phospho-alpha-D-ribose 1-diphosphate in the Pentose phosphate pathway. Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine%2C purine%2C or pyridine bases are converted to the corresponding ribonucleoside monophosphates%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2141 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2141 ZOBELLIA_2143 ZOBELLIA_2143 ZOBELLIA_2143 2500797 2501063 + Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2143 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2143 ZOBELLIA_2144 ZOBELLIA_2144 ZOBELLIA_2144 2501300 2504377 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (49-123) and the Plug module (139-247) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~Family membership gene gene2144 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2144 ZOBELLIA_2145 ZOBELLIA_2145 ZOBELLIA_2145 2504381 2505835 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2145 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2145 ZOBELLIA_2146 ZOBELLIA_2146 ZOBELLIA_2146 2505916 2507019 - Conserved hypothetical membrane protein Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2146 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2146 ZOBELLIA_2147 ZOBELLIA_2147 phoB phoB 2507033 2508841 - Alkaline phosphatase Modular protein that consists of a N-terminal conserved domain of unknown function (240 residues) and a C-terminal Alkaline phosphatase domain%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2147 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2147 ZOBELLIA_2148 ZOBELLIA_2148 ZOBELLIA_2148 2508921 2510510 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Putatively localized in the outer membrane%3B~Family membership gene gene2148 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2148 ZOBELLIA_2149 ZOBELLIA_2149 ZOBELLIA_2149 2510532 2513597 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (22-98) and the Plug module (117-220) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene2149 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2149 ZOBELLIA_215 ZOBELLIA_215 ZOBELLIA_215 263361 267488 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_215 ZOBELLIA_2150 ZOBELLIA_2150 ZOBELLIA_2150 2513776 2517507 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of an unknown function domain and a C-terminal AraC-type HTH domain%3B The periplasmic and cytoplasmic parts are separated by a transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2150 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2150 ZOBELLIA_2151 ZOBELLIA_2151 ZOBELLIA_2151 2517695 2518060 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2151 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2151 ZOBELLIA_2152 ZOBELLIA_2152 ZOBELLIA_2152 2518201 2518656 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene2152 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2152 ZOBELLIA_2153 ZOBELLIA_2153 ZOBELLIA_2153 2518712 2518804 + Putative protein Hypothetical protein gene gene2153 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2153 ZOBELLIA_2154 ZOBELLIA_2154 trmE trmE 2518801 2520198 + tRNA modification GTPase TrmE TrmE is a 3-domain protein that controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. Exhibits a very high intrinsic GTPase hydrolysis rate%3B Belongs to the Era/TrmE GTP-binding protein family%2C TrmE subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2154 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2154 ZOBELLIA_2155 ZOBELLIA_2155 cgiA2 cgiA2 2520337 2521611 - Iota-carrageenase%2C family GH82 The Iota-carrageenases hydrolyse the 1%2C4-beta-D-galactosidic linkages in the iota-carrgeenan giving the tetramer as the predominant product%3B Belongs to the family 82 of glycoside hydrolases (GH82)%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene2155 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2155 ZOBELLIA_2156 ZOBELLIA_2156 ZOBELLIA_2156 2521903 2522607 + High-affinity nickel-transport protein protein that transports nickel ions with High-affinity%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2156 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2156 ZOBELLIA_2157 ZOBELLIA_2157 ZOBELLIA_2157 2522604 2523698 - Conserved protein with NHL repeats Contains five NHL repeats involved in the formation of beta-propeller fold%3B Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene2157 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2157 ZOBELLIA_2158 ZOBELLIA_2158 hypE hypE 2523757 2524818 - Hydrogenase expression/formation protein HypE HypE (or HupE) is a protein required for expression of catalytically active hydrogenase in many systems. It appears to be an accessory protein involved in maturation rather than a regulatory protein involved in expression. HypE would be part of the hyp operon (Ni-Fe hydrogenase)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2158 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2158 ZOBELLIA_2159 ZOBELLIA_2159 ZOBELLIA_2159 2524952 2525512 - Conserved hypothetical protein Contains a domain of unknown function (DUF) 1568%3B Localized in the cytoplasm gene gene2159 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2159 ZOBELLIA_216 ZOBELLIA_216 ZOBELLIA_216 268189 268617 + Hypothetical protein Putatively localized in the cytoplasm gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_216 ZOBELLIA_2160 ZOBELLIA_2160 hypD hypD 2525562 2526656 - Hydrogenase expression/formation protein HypD HypD is involved in hydrogenase formation. HypD is a part of the hyp operon (Ni-Fe hydrogenase)%3B Contains many possible metal binding residues%2C which may bind to nickel%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2160 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2160 ZOBELLIA_2161 ZOBELLIA_2161 hypC hypC 2526663 2526941 - Hydrogenase expression/formation proteins HypC The hydrogenase expression/formation proteins HypC is a part of the operon (Ni-Fe hydrogenase). HypC is a hydrogenase precursor-specific chaperone required for a maturation process. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation in active site%3B Belongs to the hupF/hypC family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2161 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2161 ZOBELLIA_2162 ZOBELLIA_2162 hypF hypF 2526945 2529206 - Carbamoyltransferase HypF Along with hypE%2C HypF functions as a carbamoyl transferase catalyzing the synthesis of CO and CN-ligands of the active site iron of [NiFe]-hydrogenases using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of hypE yielding a protein-S-carboxamide%3B Forms a complex with hypE%3B Contains an N-terminal acylphosphatase domain%2C two repeats of zinc fingers and a C-terminal O-carbamoyltransferase domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2162 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2162 ZOBELLIA_2163 ZOBELLIA_2163 hypB hypB 2529294 2529989 - Hydrogenase nickel incorporation protein HypB The hydrogenase accessory protein HypB is a part of the hyp operon (Ni-Fe hydrogenase). HypB is a GTP hydrolase for assembly of nickel metallocentre of hydrogenase. The GTP hydrolysis catalyzed is an integral process in the incorporation of nickel into hydrogenases%3B Belongs to the hypB/hupM family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2163 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2163 ZOBELLIA_2164 ZOBELLIA_2164 hypA hypA 2530057 2530404 - hydrogenase nickel incorporation protein HypA Hydrogenase nickel insertion protein HybF is a part of hyp operon (Ni-Fe hydrogenase). HypA probably plays a role in an hydrogenase nickel cofactor insertion step%3B Contains%2C in its C-terminal region%2C four conserved cysteines that form a zinc-finger like motif%3B Belongs to the hypA/hybF family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2164 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2164 ZOBELLIA_2165 ZOBELLIA_2165 ZOBELLIA_2165 2530404 2531885 - Conserved hypothetical protein Localized in the cytoplasm gene gene2165 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2165 ZOBELLIA_2166 ZOBELLIA_2166 ZOBELLIA_2166 2531860 2532117 - Hypothetical protein Putatively localized in the cytoplasm gene gene2166 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2166 ZOBELLIA_2167 ZOBELLIA_2167 ZOBELLIA_2167 2532114 2532434 - Hypothetical protein Putatively localized in the cytoplasm gene gene2167 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2167 ZOBELLIA_2168 ZOBELLIA_2168 hyaD hyaD 2532431 2532910 - Hydrogenase maturation protease%2C family A31 Endopeptidase involved in the maturation of the large subunit of a specific Ni-Fe hydrogenase. The Ni-Fe hydrogenases contain the metallo centre%2C and once nickel has been bound in this%2C the subunit is processed to the active enzyme by cleavage at a conserved site near the C-terminus%3B Belongs to the family 31 of the aspartic peptidases (A31)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2168 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2168 ZOBELLIA_2169 ZOBELLIA_2169 hyaB hyaB 2532993 2534585 - Ni-Fe hydrogenase precursor%2C large subunit Ni-Fe hydrogenase%2C large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process%3B Forms a heterodimer%3B Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2169 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2169 ZOBELLIA_217 ZOBELLIA_217 ZOBELLIA_217 268674 269603 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_217 ZOBELLIA_2170 ZOBELLIA_2170 hyaA hyaA 2534607 2535596 - Ni-Fe hydrogenase precursor%2C small subunit Ni-Fe hydrogenase%2C large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process%3B Forms a heterodimer%3B Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2170 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2170 ZOBELLIA_2171 ZOBELLIA_2171 ZOBELLIA_2171 2535939 2537753 + Conserved hypothetical protein Localized in the cytoplasm gene gene2171 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2171 ZOBELLIA_2172 ZOBELLIA_2172 ZOBELLIA_2172 2537879 2538010 - Putative protein Hypothetical protein gene gene2172 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2172 ZOBELLIA_2173 ZOBELLIA_2173 gcdH gcdH 2538091 2539269 - Glutaryl-CoA dehydrogenase Glutaryl-CoA dehydrogenase catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine%2C L-hydroxylysine%2C and L-tryptophan metabolism%3B Uses FAD as prosthetic group%3B Belongs to the acyl-CoA dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2173 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2173 ZOBELLIA_2174 ZOBELLIA_2174 ZOBELLIA_2174 2539325 2540053 - Adenine-specific DNA methyltransferase Adenine-specific DNA methyltransferase.%3B~High confidence in function and specificity gene gene2174 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2174 ZOBELLIA_2175 ZOBELLIA_2175 ZOBELLIA_2175 2540322 2541368 + Xylose isomerase-like TIM barrel protein Xylose isomerase-like TIM barrel protein. Features a signal peptide cleaved between the residues 32 and 33. Localized in the periplasm.%3B~Conserved hypothetical protein gene gene2175 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2175 ZOBELLIA_2176 ZOBELLIA_2176 rimM rimM 2541406 2541936 - 16S rRNA processing protein RimM Specificity unclear gene gene2176 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2176 ZOBELLIA_2177 ZOBELLIA_2177 rpsP rpsP 2541953 2542504 - Ribosomal protein S16 Ribosomal protein S16 is one of the proteins from the 30S ribosomal subunit%3B In addition to being a ribosomal protein%2C S16 also has a cation-dependent endonuclease activity%3B Belongs to the ribosomal protein S16p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2177 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2177 ZOBELLIA_2178 ZOBELLIA_2178 dnaE1 dnaE1 2542812 2547248 + DNA polymerase III%2C alpha subunit The alpha subunit of DNA polymerase III is responsible of the polymerase activity%3B Contains a N-terminal exonuclease domain%2C a PHP domain (phosphoesterase) and a C-terminal OB module (oligonucleotide /oligosaccharide-binding fold) involved in the DNA binding%3B The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2178 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2178 ZOBELLIA_2179 ZOBELLIA_2179 trxA trxA 2547378 2547695 + Thioredoxin Thioredoxin is a small disulfide-containing redox protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2179 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2179 ZOBELLIA_218 ZOBELLIA_218 ZOBELLIA_218 269606 270328 + ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_218 ZOBELLIA_2180 ZOBELLIA_2180 ZOBELLIA_2180 2547809 2548738 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2180 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2180 ZOBELLIA_2182 ZOBELLIA_2182 ZOBELLIA_2182 2549250 2550062 + Deoxyribonuclease I Deoxyribonuclease I. Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm.%3B~Specificity unclear gene gene2182 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2182 ZOBELLIA_2183 ZOBELLIA_2183 ZOBELLIA_2183 2550172 2550390 - Conserved hypothetical periplasmic protein Contains a putative signal peptide cleaved between 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2183 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2183 ZOBELLIA_2184 ZOBELLIA_2184 ZOBELLIA_2184 2550377 2551429 - Conserved protein containing type I restriction enzyme R N-terminal domain Hypothetical protein gene gene2184 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2184 ZOBELLIA_2185 ZOBELLIA_2185 ZOBELLIA_2185 2551491 2551646 - Putative protein Hypothetical protein gene gene2185 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2185 ZOBELLIA_2186 ZOBELLIA_2186 ZOBELLIA_2186 2551903 2552124 - Conserved hypothetical protein Possible cytoplasmic protein gene gene2186 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2186 ZOBELLIA_2187 ZOBELLIA_2187 ZOBELLIA_2187 2552214 2552879 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LuxR-type HTH domain%2C which acts as transcriptional regulator%3B~Family membership gene gene2187 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2187 ZOBELLIA_2188 ZOBELLIA_2188 ZOBELLIA_2188 2552892 2554802 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP-dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal-dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains one transmembrane segment and one N-terminal tetratrico peptide motif (TPR)%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2188 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2188 ZOBELLIA_2189 ZOBELLIA_2189 ZOBELLIA_2189 2554908 2555063 - Putative membrane lipoprotein Lipoprotein with a signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Hypothetical protein gene gene2189 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2189 ZOBELLIA_219 ZOBELLIA_219 ZOBELLIA_219 270344 271846 + Conserved hypothetical membrane protein Contains a N-terminal and a C-terminal transmembrane segments and%2C between both transmembrane helices%2C a large periplasmic domain%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_219 ZOBELLIA_2190 ZOBELLIA_2190 ZOBELLIA_2190 2555118 2555318 + Putative protein Hypothetical protein gene gene2190 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2190 ZOBELLIA_2191 ZOBELLIA_2191 ZOBELLIA_2191 2555446 2556204 + Hypothetical membrane protein Contains one central transmembrane segment%3B Probably localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2191 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2191 ZOBELLIA_2192 ZOBELLIA_2192 sgsA2 sgsA2 2556229 2557734 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Lipoprotein with a signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene2192 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2192 ZOBELLIA_2193 ZOBELLIA_2193 ZOBELLIA_2193 2557742 2560015 - Sulfatase%2C family S1-24 / gluconolactonase Modular protein containing a N-terminal domain belonging to family 1 of sulfatases and a C-terminal gluconolactonase domain. The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates. Gluconolactonases hydrolyze the gluconolactone to gluconate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 24%3B Lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the cytoplasmic and/or the outer membrane%3B~Family membership gene gene2193 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2193 ZOBELLIA_2194 ZOBELLIA_2194 ZOBELLIA_2194 2560055 2561539 - Sulfatase%2C family S1-20 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Putative lipoprotein signal peptide cleaved between the residues 27 and 28%3B Possibly localized in the outer membrane%3B~Family membership gene gene2194 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2194 ZOBELLIA_2195 ZOBELLIA_2195 ZOBELLIA_2195 2561827 2564556 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (29-112) and the Plug module (125-207) acting as a channel gate%3B The signal peptide is cleaved between the residues 26 and 27%3B~Specificity unclear gene gene2195 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2195 ZOBELLIA_2196 ZOBELLIA_2196 sgsA3 sgsA3 2564591 2566081 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Signal peptide putatively cleaved between the residues 25 and 26%3B Possibly localized in the periplasmic space%3B~High confidence in function and specificity gene gene2196 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2196 ZOBELLIA_2197 ZOBELLIA_2197 ZOBELLIA_2197 2566101 2567441 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Family membership gene gene2197 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2197 ZOBELLIA_2198 ZOBELLIA_2198 ZOBELLIA_2198 2567458 2569584 - Sulfatase%2C family S1-20 Modular protein consisting of a N-terminal domain belonging to the family 1 of sulfatases and a C-terminal PA14 domain putatively involved in the protein or carbohydrate binding%3B The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Family membership gene gene2198 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2198 ZOBELLIA_2199 ZOBELLIA_2199 ZOBELLIA_2199 2569616 2571508 - Alpha-galactosidase%2C family GH110 Alpha-galactosidase catalyzes the hydrolysis of terminal%2C non-reducing alpha-D-galactose residues in alpha-D-galactosides. Belongs to the family 110 of the glycoside hydrolases. Likely adopts a right handed parallel beta-helix fold. Signal peptide cleaved between the residues 26 and 27. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene2199 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2199 ZOBELLIA_22 ZOBELLIA_22 hisS hisS 21170 22546 - Histidyl-tRNA synthetase Histidyl-tRNA synthetase is responsible for the attachment of histidine to the 3' OH group of ribose of its cognate transfer RNA molecule (tRNA(His)) in a highly specific two-step reaction. It is a homodimer%3B Belongs to the class-IIa aminoacyl-tRNA synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_22 ZOBELLIA_220 ZOBELLIA_220 ZOBELLIA_220 271870 272832 + Hypothetical membrane protein Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_220 ZOBELLIA_2200 ZOBELLIA_2200 ZOBELLIA_2200 2571505 2573310 - Alpha-galactosidase%2C family GH110 Alpha-galactosidase catalyzes the hydrolysis of terminal%2C non-reducing alpha-D-galactose residues in alpha-D-galactosides. Belongs to the family 110 of the glycoside hydrolases. Likely adopts a right handed parallel beta-helix fold. Signal peptide cleaved between the residues 19 and 20. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene2200 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2200 ZOBELLIA_2201 ZOBELLIA_2201 sgsA4 sgsA4 2573338 2574837 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Lipoprotein with a signal peptide cleaved between the residues 26 and 27%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene2201 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2201 ZOBELLIA_2202 ZOBELLIA_2202 ZOBELLIA_2202 2574992 2576530 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Probably localized in the outer membrane%3B~Family membership gene gene2202 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2202 ZOBELLIA_2203 ZOBELLIA_2203 ZOBELLIA_2203 2576547 2579666 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C the sulphated sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (35-109) and the Plug module (125-232) acting as a channel gate%3B The signal peptide is cleaved between the residues 32 and 33%3B~Family membership gene gene2203 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2203 ZOBELLIA_2204 ZOBELLIA_2204 ZOBELLIA_2204 2579984 2580142 - Putative protein Hypothetical protein gene gene2204 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2204 ZOBELLIA_2205 ZOBELLIA_2205 ZOBELLIA_2205 2580255 2581769 - Sulfatase%2C family S1-15 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 15%3B Signal peptide cleaved between the residues 21 and 22%3B Possibly localized in the periplasmic space%3B~Family membership gene gene2205 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2205 ZOBELLIA_2206 ZOBELLIA_2206 ZOBELLIA_2206 2581979 2582962 - Hydroxypyruvate isomerase Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)%3B Belongs to the xylose isomerase-like TIM barrel family%3B Exported by the twin-arginine translocation pathway signal%3B~High confidence in function and specificity gene gene2206 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2206 ZOBELLIA_2207 ZOBELLIA_2207 ZOBELLIA_2207 2582950 2583513 - Conserved hypothetical protein Signal peptide putatively cleaved between the residues 19 and 20%3B Localized in tyhe periplasmic space gene gene2207 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2207 ZOBELLIA_2208 ZOBELLIA_2208 ZOBELLIA_2208 2583513 2585225 - FAD-dependent oxidoreductase%2C GMC oxidoreductase family FAD-dependent oxidoreductase%3B Belongs to the GMC oxidoreductase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2208 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2208 ZOBELLIA_2209 ZOBELLIA_2209 fucA11 fucA11 2585261 2586763 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 26 and 27%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2209 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2209 ZOBELLIA_221 ZOBELLIA_221 ZOBELLIA_221 272903 274051 + Conserved hypothetical membrane protein Contains a C-terminal transmembrane segments%3B Signal peptide cleaved between the residues 27 and 28%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_221 ZOBELLIA_2210 ZOBELLIA_2210 sgsA5 sgsA5 2586778 2588355 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic membrane or/and outer membrane%3B~High confidence in function and specificity gene gene2210 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2210 ZOBELLIA_2211 ZOBELLIA_2211 ZOBELLIA_2211 2588461 2589903 - Glycoside hydrolase%2C family GH36 Glycoside hydrolase that belongs to the family 36 of glycoside hydrolases (GH36)%3B Exported in the periplasmic space by twin-arginine translocation pathway signal%3B~Family membership gene gene2211 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2211 ZOBELLIA_2212 ZOBELLIA_2212 ZOBELLIA_2212 2589911 2591623 - conserved hypothetical protein Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space gene gene2212 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2212 ZOBELLIA_2213 ZOBELLIA_2213 ZOBELLIA_2213 2591638 2592387 - Acetylesterase%2C lipase-GDSL family Acetylesterase that belongs to the lipase-GDSL Pfam family%2C which includes families 3 and 12 of the carbohydrate esterases (CE3%2C CE12)%3B The conserved catalytic residues are Ser38%2C Asp194 and His197. Lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Specificity unclear gene gene2213 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2213 ZOBELLIA_2214 ZOBELLIA_2214 ZOBELLIA_2214 2592405 2593988 - Sulfatase%2C family S1-20 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2214 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2214 ZOBELLIA_2215 ZOBELLIA_2215 ZOBELLIA_2215 2594007 2595527 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Family membership gene gene2215 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2215 ZOBELLIA_2216 ZOBELLIA_2216 sgsA6 sgsA6 2595528 2597072 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2216 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2216 ZOBELLIA_2217 ZOBELLIA_2217 ZOBELLIA_2217 2597133 2597597 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2217 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2217 ZOBELLIA_2218 ZOBELLIA_2218 ZOBELLIA_2218 2597626 2599428 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Family membership gene gene2218 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2218 ZOBELLIA_2219 ZOBELLIA_2219 ZOBELLIA_2219 2599447 2602542 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly suphated sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (31-106) and the Plug module (122-225) acting as a channel gate%3B The signal peptide is cleaved between the residues 29 and 30%3B~Family membership gene gene2219 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2219 ZOBELLIA_222 ZOBELLIA_222 ZOBELLIA_222 274051 275013 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B Belongs to the type I secretion system%3B~Family membership gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_222 ZOBELLIA_2220 ZOBELLIA_2220 ZOBELLIA_2220 2602910 2607025 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2220 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2220 ZOBELLIA_2221 ZOBELLIA_2221 ZOBELLIA_2221 2607171 2608238 - Kinase%2C aminoglycoside phosphotransferase family Transferase transferring phosphorus-containing groups%3B Belongs to the aminoglycoside phosphotransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene2221 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2221 ZOBELLIA_2222 ZOBELLIA_2222 galF galF 2608238 2609128 - UTP--glucose-1-phosphate uridylyltransferase Enzyme involved in Lipopolysaccharide O antigen biosynthesis. It biosynthetizes UDP-glucose from uridine triphosphate and glucose 1-phosphate%3B Belongs to the UDPGP type 2 family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2222 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2222 ZOBELLIA_2223 ZOBELLIA_2223 ZOBELLIA_2223 2609333 2610361 - DeoR-type transcriptional regulator DeoR-type transcription regulator are repressors of sugar and nucleoside metabolic systems. The effector molecules are generally phosphorylated intermediates of the relevant metabolic pathway. Contains a N-terminal DNA-binding DeoR-type HTH domain. The C-terminal part can contain an effector-binding domain and/or an oligomerization domain%3B Localized in the cytoplasm%3B~Family membership gene gene2223 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2223 ZOBELLIA_2224 ZOBELLIA_2224 ZOBELLIA_2224 2610443 2611468 - LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2224 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2224 ZOBELLIA_2225 ZOBELLIA_2225 ZOBELLIA_2225 2611665 2614343 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-99) and the Plug module (116-229) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene2225 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2225 ZOBELLIA_2226 ZOBELLIA_2226 ZOBELLIA_2226 2614439 2615749 + Conserved hypothetical protein Conserved hypothetical protein distantly related to the glycoside hydrolases of the families GH37 and GH63 (clan GH-G)%3B Localized in the cytoplasm gene gene2226 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2226 ZOBELLIA_2227 ZOBELLIA_2227 ZOBELLIA_2227 2615762 2615992 - Putative protein Hypothetical protein gene gene2227 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2227 ZOBELLIA_2228 ZOBELLIA_2228 nisA nisA 2616047 2617651 + Sodium/iodide symporter Transporter that mediates iodide uptake. Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes. Thereby the energy stored in an inwardly directed electrochemical sodium gradient is used to drive solute accumulation against a concentration gradient%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2228 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2228 ZOBELLIA_2229 ZOBELLIA_2229 glxK glxK 2617662 2618786 + Glycerate kinase Enzyme involved in glycine%2C serine and threonine metabolism%2C Glycerolipid metabolism and Glyoxylate and dicarboxylate metabolism%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2229 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2229 ZOBELLIA_223 ZOBELLIA_223 ZOBELLIA_223 275016 276092 + ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_223 ZOBELLIA_2230 ZOBELLIA_2230 ZOBELLIA_2230 2618940 2619440 + DinB family protein The DNA damage-inducible (din) genes are coordinately regulated and together compose a global regulatory network that has been termed the SOS-like or SOB regulon%3B Belongs to the DinB family%3B Localized in the cytoplasm%3B~Function unclear gene gene2230 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2230 ZOBELLIA_2231 ZOBELLIA_2231 ZOBELLIA_2231 2619459 2619668 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene2231 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2231 ZOBELLIA_2232 ZOBELLIA_2232 hemN hemN 2619764 2621125 + Oxygen-independent coproporphyrinogen III oxidase Oxygen-independent coproporphyrinogen III oxidase is involved in Porphyrin biosynthesis. It Catalysis the reaction: Coproporphyrinogen-III + 2 S-adenosyl-L-methionine %3D protoporphyrinogen-IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine%3B Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2232 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2232 ZOBELLIA_2233 ZOBELLIA_2233 ZOBELLIA_2233 2621156 2621977 + Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains two copies of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS- box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene2233 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2233 ZOBELLIA_2234 ZOBELLIA_2234 ZOBELLIA_2234 2622051 2623442 - NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase%3B Contains a NAD- and NADP-binding domains with a core Rossmann-type fold%3B Belongs to the GFO/IDH/MOCA family%3B Contains an twin-arginine translocation signal peptide%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2234 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2234 ZOBELLIA_2235 ZOBELLIA_2235 ZOBELLIA_2235 2623619 2624131 + Cytochrome c Cytochromes c typically function in electron transfer. They are required during oxidative phosphorylation as an electron shuttle between Complex III (cytochrome c reductase) and IV (cytochrome c oxidase)%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Cytochrome c binds a heme as prosthetic group by Cys93 and Cys96. His97 is involved in iron binding%3B Belongs to class I (mono-heme) of Cytochrome c%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic and/or outer membrane%3B~Family membership gene gene2235 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2235 ZOBELLIA_2236 ZOBELLIA_2236 nosZ nosZ 2624197 2626158 + Nitrous oxide reductase Nitrous-oxide reductase is a copper-containing enzyme that catalyses the two-electron reduction of the greenhouse gas N2O to N2. It is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide. Homodimer that Binds 6 copper ions per subunit. Signal peptide of lipoprotein cleaved between the residues 20 and 21. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2236 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2236 ZOBELLIA_2237 ZOBELLIA_2237 ZOBELLIA_2237 2626273 2626917 + Conserved hypothetical membrane protein Contains four transmembranes segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2237 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2237 ZOBELLIA_2238 ZOBELLIA_2238 nosL nosL 2626914 2627360 + Copper-binding lipoprotein NosL is one of the accessory lipoproteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue%2C and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallocenter assembly. Signal peptide cleaved between the residues 17 and 18. Localized in the outer membrane.%3B~High confidence in function and specificity gene gene2238 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2238 ZOBELLIA_2239 ZOBELLIA_2239 ZOBELLIA_2239 2627374 2627835 + Flavin mononucleotide binding protein Flavin mononucleotide binding protein belonging to the Pyridoxamine 5'-phosphate oxidase family%3B The structure could be a FMN-binding split barrel%2C which is related to the ferredoxin reductase-like FAD-binding domain%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2239 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2239 ZOBELLIA_224 ZOBELLIA_224 ZOBELLIA_224 276109 276252 + Putative protein Hypothetical protein gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_224 ZOBELLIA_2240 ZOBELLIA_2240 nosD nosD 2628082 2629323 + Copper-binding periplasmic protein Protein which is thought to insert copper into the exported nitrous oxide reductase apoenzyme (NosZ). Belongs to the nitrous oxide reductase operon. Signal peptide cleaved between the residues 22 and 23. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene2240 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2240 ZOBELLIA_2241 ZOBELLIA_2241 nosF nosF 2629320 2630030 + Copper ABC transporter%2C ATPase component This protein%2C involved in copper processing/transport%2C is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane). Belongs to the nitrous oxide reductase operon. It is a peripheral membrane protein localized near of the cytoplasmic membrane by association with the permease component.%3B~High confidence in function and specificity gene gene2241 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2241 ZOBELLIA_2242 ZOBELLIA_2242 nosY nosY 2630023 2630805 + Copper ABC importer%2C permease component ABC (ATP-binding cassette) transporter%2C membrane domain. Proteins responsible for import of multi-copper across biological membranes. Contains six transmembrane segmemts%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2242 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2242 ZOBELLIA_2243 ZOBELLIA_2243 ZOBELLIA_2243 2630860 2632041 + Conserved hypothetical membrane protein Contains twelve transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2243 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2243 ZOBELLIA_2244 ZOBELLIA_2244 fdxA2 fdxA2 2632046 2632378 - 2Fe-2S ferredoxin Ferredoxins are electron carrier proteins with an iron-sulfur as cofactor and that transfer electrons in a wide variety of metabolic reactions. Belongs to the putidaredoxin%2C terpredoxin and adrenodoxin sub-family and uses 2Fe-2S cluster as cofactor ligated at four conserved cysteine residues. The general core structure consists of beta(2)-alpha-beta(2). Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2244 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2244 ZOBELLIA_2245 ZOBELLIA_2245 ZOBELLIA_2245 2632402 2632749 - Conserved hypothetical membrane protein Contains three C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2245 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2245 ZOBELLIA_2246 ZOBELLIA_2246 scdA scdA 2632809 2633528 - Cell wall-related protein ScdA Involved in peptidoglycan cross-linking. Required for normal cell growth and development. Contains two Hemerythrin HHE cation binding domains.%3B~Family membership gene gene2246 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2246 ZOBELLIA_2247 ZOBELLIA_2247 ZOBELLIA_2247 2633597 2634031 - Rrf2-type transcriptional regulator The transcriptional regulators with the Rrf2-type HTH domain control a variety of operons that encode iron-sulfur-containing proteins as well as other proteins involved in electron transport. Other rrf2-type HTH proteins are repressors of genes involved in nitrite or iron metabolism. The C-terminal part of the rrf2-type HTH domain contains 3 conserved cysteine residues that may bind an Fe-S cluster. Contains a DNA-binding%2C winged helix-turn-helix (wHTH) domain. Localized in the cytoplasm.%3B~Family membership gene gene2247 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2247 ZOBELLIA_2248 ZOBELLIA_2248 ZOBELLIA_2248 2634116 2634508 - Globin-like protein Truncated hemoglobin.%3B~Family membership gene gene2248 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2248 ZOBELLIA_2249 ZOBELLIA_2249 cat2 cat2 2634533 2635801 - 4-hydroxybutyrate coenzyme A transferase Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate.%3B~High confidence in function and specificity gene gene2249 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2249 ZOBELLIA_225 ZOBELLIA_225 ZOBELLIA_225 276283 276444 - Hypothetical protein Protein fragment found in various hypothetical proteins from many bacteroidetes gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_225 ZOBELLIA_2250 ZOBELLIA_2250 ZOBELLIA_2250 2635935 2637389 - Vanadium-dependent haloperoxidase Vanadium-dependent Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide%2C which results in subsequent halogenation of organic substrates%2C or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products%2C such as volatile halogenated hydrocarbons%2C chiral halogenated terpenes%2C acetogenins and indoles%3B Signal peptide cleaved between the residues 21 and 22%3B localized in the periplasmic space%3B~Specificity unclear gene gene2250 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2250 ZOBELLIA_2251 ZOBELLIA_2251 ZOBELLIA_2251 2637446 2637943 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2251 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2251 ZOBELLIA_2252 ZOBELLIA_2252 ccdA ccdA 2637971 2638675 - Cytochrome C biogenesis protein Belongs to the DsbD family. Like the Cytochrome C biogenesis protein CcdA from Bacillus subtilis%2C this protein is limited to the transmembrane region of DsbD. Preceded by the cytochrome cbb3 oxidase operon. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene2252 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2252 ZOBELLIA_2253 ZOBELLIA_2253 ccoH ccoH 2638683 2639129 - FixH-like protein Protein that consists of a FixH family domain. Could be a cytochrome cbb3 oxidase maturation protein%3B Contains one N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2253 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2253 ZOBELLIA_2254 ZOBELLIA_2254 ccoG ccoG 2639148 2640566 - 4Fe-4S ferredoxin Belongs to the ccoGHIS operon. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2254 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2254 ZOBELLIA_2255 ZOBELLIA_2255 ccoP ccoP 2640612 2641565 - Cytochrome cbb3 oxidase%2C CcoP subunit Belongs to the ccoNOPQ operon. Features three transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2255 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2255 ZOBELLIA_2256 ZOBELLIA_2256 ccoQ ccoQ 2641562 2641753 - Cytochrome cbb3 oxidase%2C CcoQ subunit CcoQ is a subunit of the cytochrome cbb3 oxidase. Converts the ferrocytochrome c to ferricytochrome c. Belongs to the ccoNOPQ operon. Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2256 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2256 ZOBELLIA_2257 ZOBELLIA_2257 ccoNO ccoNO 2641759 2643963 - Cytochrome cbb3 oxidase%2C CcoN and CcoO subunits Fusion of the subunits CcoN and CcoO of the Cytochrome cbb3 oxidase. Converts the ferrocytochrome to ferricytochrome. Belongs to the ccoNOQP operon. Contains 13 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2257 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2257 ZOBELLIA_2258 ZOBELLIA_2258 ccoS ccoS 2643966 2644175 - Cytochrome cbb3 oxidase maturation protein Involved in the ccoGHIS operon. Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2258 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2258 ZOBELLIA_2259 ZOBELLIA_2259 ZOBELLIA_2259 2644375 2644809 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2259 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2259 ZOBELLIA_226 ZOBELLIA_226 ZOBELLIA_226 276509 277369 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_226 ZOBELLIA_2260 ZOBELLIA_2260 ccoI ccoI 2644923 2647319 - Cation-transporting P-type ATPase Belongs to the cation transport P-type ATPase family. Involved in the ccoGHIS operon. Features eight transmembrane helices. Localized in the cytoplasmic membrane.%3B~Hypothetical protein gene gene2260 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2260 ZOBELLIA_2261 ZOBELLIA_2261 ZOBELLIA_2261 2647467 2648156 + cAMP-binding regulatory protein%2C Fnr family This protein complexes with cyclic AMP via an N-terminal cyclic nucleotide-binding domain and binds to specific DNA sites%2C via a C-terminal crp-type HTH domain%2C near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA%3B Probably binds 1 4Fe-4S cluster per subunit as cofactor%3B~Family membership gene gene2261 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2261 ZOBELLIA_2262 ZOBELLIA_2262 ZOBELLIA_2262 2648244 2649149 + Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains one N-terminal copy of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene2262 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2262 ZOBELLIA_2263 ZOBELLIA_2263 ndhA2 ndhA2 2649305 2650582 + FAD-dependent pyridine nucleotide-disulphide oxidoreductase%2C membrane NADH dehydrogenases catalyze the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation%3B Binds 1 FAD noncovalently per subunit%3B Contains two tranmembrane segments%3B Belongs to the NADH dehydrogenase family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2263 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2263 ZOBELLIA_2264 ZOBELLIA_2264 ZOBELLIA_2264 2650618 2650869 - Putative protein Hypothetical protein gene gene2264 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2264 ZOBELLIA_2265 ZOBELLIA_2265 hmgA hmgA 2651198 2652355 + Homogentisate 1%2C2-dioxygenase Catalytic activity: Homogentisate + O2 %3D 4-maleylacetoacetate. Tyrosine metabolism and Styrene degradation.%3B~High confidence in function and specificity gene gene2265 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2265 ZOBELLIA_2266 ZOBELLIA_2266 ZOBELLIA_2266 2652420 2652998 + NAD(P)H nitroreductase Specificity unclear gene gene2266 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2266 ZOBELLIA_2267 ZOBELLIA_2267 pbpE pbpE 2653013 2654332 - Penicillin-binding protein 4*%2C family S12 Penicillin-binding protein 4* or PBP 4A is probably involved in peptidoglycan biosynthesis. Belongs to the family 12 of the serine peptidases. Signal peptide cleaved between the residues 20 and 21. Localized in the periplasmic space.%3B~High confidence in function and specificity gene gene2267 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2267 ZOBELLIA_2268 ZOBELLIA_2268 ZOBELLIA_2268 2654346 2654894 - DUF456 family protein Conserved protein belonging to the DUF456 family. Features four transmembrane helices. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene2268 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2268 ZOBELLIA_2269 ZOBELLIA_2269 ZOBELLIA_2269 2655071 2655460 + BlaI-type transcriptional repressor Transcriptional repressor. The BlaI like repressors form homodimers that specifically bind DNA operator/promoter sequences. Followed by a blaR1-like regulator protein.%3B~High confidence in function and specificity gene gene2269 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2269 ZOBELLIA_227 ZOBELLIA_227 ZOBELLIA_227 277631 280720 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (28-104) and the Plug module (120-230) acting as a channel gate%3B The signal peptide is cleaved between the residues 25 and 26%3B~Family membership gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_227 ZOBELLIA_2270 ZOBELLIA_2270 ZOBELLIA_2270 2655472 2657436 + BlaR1-type regulatory protein / TonB protein Modular protein containing a N-terminal BlaR1-like regulatory module and two C-terminal TonB domains. BlaR1-like regulatory proteins are membrane-spanning signal transducers that contain a N-terminal metallopeptidase-M56 domain%2C possibly involved in the proteolytic inactivation of the BlaI-like repressor%2C and a central extracellular binding protein domain of unknown specificity. TonB domain%2C suggested to span the periplasm%2C is found in the C-terminal part of the protein TonB that is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria%3B Contains three transmembrane segments%3B localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2270 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2270 ZOBELLIA_2271 ZOBELLIA_2271 ZOBELLIA_2271 2657440 2658579 + O-linked N-acetylglucosaminyltransferase%2C family GT41 Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide. Contains Tetratricopeptide repeats%3B Seems to have an uncleavable N-terminal signal sequence%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2271 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2271 ZOBELLIA_2272 ZOBELLIA_2272 ZOBELLIA_2272 2658626 2659183 - Hypothetical protein Contains an uncleavable N-terminal signal sequence gene gene2272 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2272 ZOBELLIA_2273 ZOBELLIA_2273 ruvC ruvC 2659189 2659743 + Crossover junction endodeoxyribonuclease RuvC Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2273 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2273 ZOBELLIA_2274 ZOBELLIA_2274 hemN hemN 2659958 2661091 + Oxygen-independent coproporphyrinogen III oxidase Oxygen-independent coproporphyrinogen III oxidase. Involved in Porphyrin biosynthesis. Catalysis of the reaction: Coproporphyrinogen-III + 2 S-adenosyl-L-methionine %3D protoporphyrinogen-IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2274 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2274 ZOBELLIA_2275 ZOBELLIA_2275 ZOBELLIA_2275 2661176 2661928 + N-formylkynurenine (aryl-) formamidase N-formylkynurenine (aryl-) formamidase is an enzyme involved in the tryptophan metabolism. It hydrolyses the N-formyl-L-kynurenine to L-kynurenine and formate%3B belongs to the cyclase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2275 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2275 ZOBELLIA_2276 ZOBELLIA_2276 ZOBELLIA_2276 2661925 2662275 + conserved hypothetical membrane protein Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2276 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2276 ZOBELLIA_2277 ZOBELLIA_2277 ZOBELLIA_2277 2662277 2662900 + Conserved hypothetical protein Protein with an uncleaved signal peptide%3B Seems localized in the cytoplasmic membrane gene gene2277 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2277 ZOBELLIA_2278 ZOBELLIA_2278 ZOBELLIA_2278 2662906 2663328 + Stress responsive A/B barrel domain Localized in the periplasmic space%3B~Family membership gene gene2278 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2278 ZOBELLIA_2279 ZOBELLIA_2279 ZOBELLIA_2279 2663336 2663884 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene2279 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2279 ZOBELLIA_228 ZOBELLIA_228 ZOBELLIA_228 280733 282229 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_228 ZOBELLIA_2280 ZOBELLIA_2280 ZOBELLIA_2280 2663881 2664237 + Conserved hypothetical protein Conserved hypothetical protein belonging to the MmcQ family%3B Localized in the cytoplasm gene gene2280 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2280 ZOBELLIA_2281 ZOBELLIA_2281 mutS3 mutS3 2664284 2666056 + DNA mismatch repair protein MutS The protein MutS is involved in the repair of mismatches in DNA. It plays a key role in the recognition and repair of errors made during the replication of DNA. This protein has a weak ATPase activity%3B Contains three transmembrane segments and a C-terminal MutS_V domain%3B Belongs to the MutS family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2281 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2281 ZOBELLIA_2282 ZOBELLIA_2282 ZOBELLIA_2282 2666081 2667082 + Conserved hypothetical membrane protein Possible membrane-bound metal-dependent hydrolase%3B Contains four N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2282 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2282 ZOBELLIA_2283 ZOBELLIA_2283 ZOBELLIA_2283 2667331 2667675 + conserved hypothetical protein Localized in the cytoplasm gene gene2283 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2283 ZOBELLIA_2284 ZOBELLIA_2284 ZOBELLIA_2284 2667687 2668787 - Conserved hypothetical membrane protein Contains two N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2284 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2284 ZOBELLIA_2285 ZOBELLIA_2285 ZOBELLIA_2285 2668914 2670599 - BlaR1-type regulatory protein BlaR1-type regulatory proteins are signal-transducing proteins that are a fusion protein with a N-terminal zinc metallopeptidase-M56 domain that proteolytically inactivate the cytoplasmic BlaI-type transcriptional repressor%2C and a beta-lactams-binding domain%3B Contains at least four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2285 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2285 ZOBELLIA_2286 ZOBELLIA_2286 ZOBELLIA_2286 2670602 2671045 - BlaI-type transcriptional regulator BlaI-type transcriptional regulator are repressors usually involved in regulation of resistance to beta-lactams%3B The N-terminal region of these proteins is involved in DNA operator sequence recognition%2C while the C-terminal is responsible for dimerisation of the protein%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2286 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2286 ZOBELLIA_2287 ZOBELLIA_2287 phnA phnA 2671261 2671839 + PhnA protein Zn-ribbon-containing protein involved in phosphonate metabolism%3B~Family membership gene gene2287 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2287 ZOBELLIA_2288 ZOBELLIA_2288 ZOBELLIA_2288 2671880 2673268 - Metallopeptidase%2C family M20A Peptidase family M20 contains exopeptidases: carboxypeptidases%2C dipeptidases and a specialised aminopeptidase. These peptidases are of the 'co- catalytic' type%2C binding two metal ions per monomer of protein. The roles of the two catalytic zinc ions can be described as stabilization of the tetrahedral intermediate and activation of the catalytic water molecule.%3B~Specificity unclear gene gene2288 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2288 ZOBELLIA_229 ZOBELLIA_229 ZOBELLIA_229 282229 283158 + Hypothetical lipoprotein Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane%3B~Hypothetical protein gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_229 ZOBELLIA_2290 ZOBELLIA_2290 ZOBELLIA_2290 2673909 2674706 - Conserved hypothetical membrane protein Protein consisting to a domain of unknown function DUF1080%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene2290 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2290 ZOBELLIA_2291 ZOBELLIA_2291 ZOBELLIA_2291 2674798 2676558 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 16 and 17%3B Probably localized in the outer membrane%3B~Family membership gene gene2291 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2291 ZOBELLIA_2292 ZOBELLIA_2292 ZOBELLIA_2292 2676568 2680044 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (50-102)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (121-195) and a Plug module (211-315) acting as the channel gate%3B The signal peptide is cleaved between the residue 19 and 20%3B~Family membership gene gene2292 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2292 ZOBELLIA_2293 ZOBELLIA_2293 ZOBELLIA_2293 2680252 2681421 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene2293 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2293 ZOBELLIA_2294 ZOBELLIA_2294 ZOBELLIA_2294 2681485 2682021 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene2294 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2294 ZOBELLIA_2295 ZOBELLIA_2295 ZOBELLIA_2295 2682401 2682616 - Putative protein Hypothetical protein gene gene2295 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2295 ZOBELLIA_2296 ZOBELLIA_2296 ZOBELLIA_2296 2682750 2684339 - Conserved lipoprotein containing CBM22 Conserved protein containing a N-terminal domain of unknown function and a C-terminal Carbohydrate Binding Module of family 22. Lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2296 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2296 ZOBELLIA_2297 ZOBELLIA_2297 ZOBELLIA_2297 2684357 2686069 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Putatively localized in the outer membrane%3B~Family membership gene gene2297 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2297 ZOBELLIA_2298 ZOBELLIA_2298 ZOBELLIA_2298 2686087 2689170 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (30-104) and the Plug module (120-227) acting as a channel gate%3B The signal peptide is cleaved between the residues 24 and 25%3B~Family membership gene gene2298 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2298 ZOBELLIA_2299 ZOBELLIA_2299 ZOBELLIA_2299 2689443 2689658 + Putative protein Hypothetical protein gene gene2299 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2299 ZOBELLIA_23 ZOBELLIA_23 ZOBELLIA_23 22660 23133 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_23 ZOBELLIA_230 ZOBELLIA_230 ZOBELLIA_230 283208 284761 + Conserved hypothetical lipoprotein Seems to contain a signal peptide of lipoprotein cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_230 ZOBELLIA_2300 ZOBELLIA_2300 ZOBELLIA_2300 2689714 2690010 - Hypothetical protein Possibly localized in the cytoplasm gene gene2300 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2300 ZOBELLIA_2301 ZOBELLIA_2301 ZOBELLIA_2301 2690082 2690402 + Hypothetical membrane protein Contains one N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2301 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2301 ZOBELLIA_2302 ZOBELLIA_2302 ZOBELLIA_2302 2690551 2691366 - Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains one N-terminal copy of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene2302 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2302 ZOBELLIA_2303 ZOBELLIA_2303 ZOBELLIA_2303 2691760 2695863 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2303 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2303 ZOBELLIA_2304 ZOBELLIA_2304 ZOBELLIA_2304 2696309 2696542 - Putative protein Hypothetical protein gene gene2304 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2304 ZOBELLIA_2305 ZOBELLIA_2305 ZOBELLIA_2305 2696784 2699882 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (37-110) and the Plug module (126-232) acting as a channel gate%3B The signal peptide is cleaved between the residues 33 and 34%3B~Family membership gene gene2305 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2305 ZOBELLIA_2306 ZOBELLIA_2306 ZOBELLIA_2306 2699895 2701640 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 21 and 22%3B Probably localized in the cytoplasmic membrane%3B~Family membership gene gene2306 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2306 ZOBELLIA_2307 ZOBELLIA_2307 ZOBELLIA_2307 2701657 2703330 + Conserved lipoprotein containing CBM22 Conserved protein containing a N-terminal domain of unknown function and a C-terminal Carbohydrate Binding Module of the family 22%3B Lipoprotein signal peptide cleaved between 17 and 18%3B Localized in the outer membrane%3B~Specificity unclear gene gene2307 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2307 ZOBELLIA_2308 ZOBELLIA_2308 ZOBELLIA_2308 2703596 2706616 + Conserved hypothetical protein Shows a weak similarity with the glycoside hydrolases of the family 42 (GH42)%3B Seems to be a lipoprotein with a signal peptide cleaved between residues 15 and 16%3B Putatively localised in the outer membrane gene gene2308 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2308 ZOBELLIA_2309 ZOBELLIA_2309 ZOBELLIA_2309 2706948 2707115 + Hypothetical protein Peptide that represents a C-terminal fragment of putative sialic-acid O-acetylesterase%3B Localized in the cytoplasm gene gene2309 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2309 ZOBELLIA_231 ZOBELLIA_231 ZOBELLIA_231 284828 285847 + Putative glycoside hydrolase Conserved protein which is predicted as a possible new glycoside hydrolase family%3B Belongs to the DUF377 family%3B Localized in the cytoplasm%3B~Family membership gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_231 ZOBELLIA_2310 ZOBELLIA_2310 bgaE bgaE 2707128 2710211 - Beta-galactosidase%2C family GH2 Modular protein with a N-terminal beta-galactosidase domain belonging to the family 2 of glycoside hydrolases (GH2%2C TIM alpha/beta barrel fold) and a C-terminal Carbohydrate Binding Module of family CBM35%3B Catalyzes the hydrolysis of the beta-1%2C4 linkage at the terminal non-reducing%2C releasing a beta-D-galactose residue from beta-D-galactosides%3B Signal peptide cleaved between residues 28 and 29%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2310 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2310 ZOBELLIA_2311 ZOBELLIA_2311 ZOBELLIA_2311 2710607 2710915 + Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2311 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2311 ZOBELLIA_2312 ZOBELLIA_2312 ZOBELLIA_2312 2711146 2713515 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (24-109) and the Plug module (117-223) acting as the channel gate%3B The signal peptide is cleaved between the residue 20 and 21%3B~Family membership gene gene2312 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2312 ZOBELLIA_2313 ZOBELLIA_2313 ZOBELLIA_2313 2713527 2714333 + Conserved hypothetical lipoprotein Contains a signal peptide of lipoprotein cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2313 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2313 ZOBELLIA_2314 ZOBELLIA_2314 ZOBELLIA_2314 2714394 2714867 + Conserved hypothetical lipoprotein Signal peptide of lipoproteins cleaved between residues 19 and 20%3B Probably localised in the outer membrane%3B~Conserved hypothetical protein gene gene2314 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2314 ZOBELLIA_2315 ZOBELLIA_2315 ZOBELLIA_2315 2715028 2717958 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (59-110)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (120-194) and the Plug module (212-335)%3B The signal peptide is cleaved between the residue 29 and 30%3B~Family membership gene gene2315 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2315 ZOBELLIA_2316 ZOBELLIA_2316 ZOBELLIA_2316 2718032 2719198 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene2316 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2316 ZOBELLIA_2317 ZOBELLIA_2317 ZOBELLIA_2317 2719294 2719848 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene2317 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2317 ZOBELLIA_2318 ZOBELLIA_2318 ZOBELLIA_2318 2719875 2721068 - Fumarylacetoacetate hydrolase Fumarylacetoacetate hydrolase (FAH)%2C or fumarylacetoacetase (FAA) is the last enzyme in the tyrosine catabolic pathway%2C it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2318 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2318 ZOBELLIA_2319 ZOBELLIA_2319 ZOBELLIA_2319 2721516 2722367 + Sugar phosphate isomerases/epimerases Protein exported in the periplasmic space by the twin-arginine translocation pathway caracterised by a non-Sec signal sequences%3B The signal peptide is cleaved between residues 33 and 34%3B~Family membership gene gene2319 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2319 ZOBELLIA_232 ZOBELLIA_232 ZOBELLIA_232 286004 287641 + Sodium/glucose symporter Sodium/glucose symporter actively transports glucose into cells by Na+ cotransport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_232 ZOBELLIA_2320 ZOBELLIA_2320 ZOBELLIA_2320 2722377 2723720 + NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase. Belongs to the Rossmann fold family. Features a twin-arginine translocation signal peptide cleaved between the residues 29 and 30. Localized in the periplasm.%3B~Specificity unclear gene gene2320 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2320 ZOBELLIA_2321 ZOBELLIA_2321 kdtA kdtA 2724143 2725378 - 3-deoxy-D-manno-octulosonic-acid transferase%2C family GT30 KtdA catalyzes the transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1%2C4'-bisphosphate precursor of lipid A (lipid IVA). This is a essential step in lipopolysaccharides biosynthesis. KtdA belongs to the family 30 of glycosyltransferases.%3B~High confidence in function and specificity gene gene2321 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2321 ZOBELLIA_2322 ZOBELLIA_2322 porR porR 2725470 2726624 + PorR protein%2C PLP-dependent aminotransferase family PorR belongs to the DegT/DnrJ/EryC1/StrS aminotransferase family%2C which is included in the pyridoxal-phosphate (PLP)-dependent aminotransferase superfamily. PorR is involved in the biosynthesis of cell surface polysaccharides. In Porphyromonas gingivalis the porR mutant showed a pleiotropic phenotype: loss of pigmentation%2C delayed maturation of fimbrillin%2C preferential presence of Rgp and Kgp proteinases in culture supernatants%2C and no haemagglutination.%3B~Specificity unclear gene gene2322 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2322 ZOBELLIA_2323 ZOBELLIA_2323 galE galE 2726732 2727748 + UDP-glucose 4-epimerase GalE interconverts UDP-glucose and UDP-galactose which are precursors of glucose- and galactose-containing exopolysaccharides (EPS). Belongs to the NAD dependent epimerase/dehydratase family%2C which is included in the Rossmann fold Superfamily.%3B~High confidence in function and specificity gene gene2323 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2323 ZOBELLIA_2324 ZOBELLIA_2324 ZOBELLIA_2324 2727829 2728182 + Conserved hypothetical protein Localized in the cytoplasm gene gene2324 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2324 ZOBELLIA_2325 ZOBELLIA_2325 ZOBELLIA_2325 2728179 2728715 - Hypothetical membrane protein Signal peptide cleaved between the residues 27 and 28%3B Putatively localised in the outer membrane%3B~Hypothetical protein gene gene2325 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2325 ZOBELLIA_2326 ZOBELLIA_2326 sucA sucA 2728813 2731626 + 2-oxoglutarate dehydrogenase E1 component The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)%3B~High confidence in function and specificity gene gene2326 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2326 ZOBELLIA_2327 ZOBELLIA_2327 sucB sucB 2731675 2732892 + Dihydrolipoamide succinyltransferase E2 component The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)%3B Protein contains a biotinyl/lipoyl domain%3B~High confidence in function and specificity gene gene2327 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2327 ZOBELLIA_2328 ZOBELLIA_2328 ZOBELLIA_2328 2732991 2733431 - Aspartic peptidase%2C family A2 This enzyme belongs to the family 2 of the aspartic peptidases. An activated water molecule is the nucleophile these peptidases and is bound by two aspartic residues%2C one from each monomer of the homo-dimeric molecule. Localized in the cytoplasm.%3B~Specificity unclear gene gene2328 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2328 ZOBELLIA_2329 ZOBELLIA_2329 tatD tatD 2733469 2734236 + Mg-dependent DNase TatD is a cytoplasmic protein with DNase activity%3B~Family membership gene gene2329 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2329 ZOBELLIA_233 ZOBELLIA_233 bnaI bnaI 287724 288557 + Acetylxylan esterase%2C family CE6 Acetylxylan esterase catalyzes the deacetylation of xylans and xylo-oligosaccharides. Belongs to the family 6 of the carbohydrate esterases. Features a signal peptide cleaved between residues 20 and 21. Localized in the periplasm.%3B~High confidence in function and specificity gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_233 ZOBELLIA_2330 ZOBELLIA_2330 ansA ansA 2734268 2735299 + Asparaginase%2C type I Asparaginase%2C which is found in various plant%2C animal and bacterial cells%2C catalyses the deamination of asparagine to yield aspartic acid and an ammonium ion.%3B~High confidence in function and specificity gene gene2330 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2330 ZOBELLIA_2332 ZOBELLIA_2332 exbB exbB 2735748 2736494 + Biopolymer transport protein ExbB ExbB is involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. ExbB protects ExbD from proteolytic degradation and functionally stabilizes tonB. TonB is coupled to the protomotive force by the ExbB/ExbD complex which is required for the energization of TonB%3B Contains four transmembrane segments%3B Belongs to the ExbB/TolQ family%3B Signal peptide cleaved between residues 23 and 24%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2332 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2332 ZOBELLIA_2333 ZOBELLIA_2333 ZOBELLIA_2333 2736520 2736960 + Conserved hypothetical membrane protein Contains 4 transmembrane segmemts%3B Probably localised in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2333 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2333 ZOBELLIA_2334 ZOBELLIA_2334 exbD1 exbD1 2736976 2737602 + Biopolymer transport protein ExbD ExbD is involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. ExbD forms a complex with ExbB. This complex is required for the efficient energization of tonB from the protomotive force%3B Contains a N-terminal transmembrane helix%3B Belongs to the exbD/tolR family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2334 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2334 ZOBELLIA_2335 ZOBELLIA_2335 exbD2 exbD2 2737624 2738106 + Biopolymer transport protein ExbD ExbD is involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. ExbD forms a complex with ExbB. This complex is required for the efficient energization of tonB from the protomotive force%3B Contains a N-terminal transmembrane helix%3B Belongs to the exbD/tolR family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2335 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2335 ZOBELLIA_2336 ZOBELLIA_2336 ZOBELLIA_2336 2738188 2738874 + Hypothetical membrane protein Signal peptide cleaved betwenn the residues 19 and 20%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene2336 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2336 ZOBELLIA_2337 ZOBELLIA_2337 ZOBELLIA_2337 2738869 2739474 - Hypothetical membrane protein Contains seven transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2337 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2337 ZOBELLIA_2338 ZOBELLIA_2338 rpoN rpoN 2739474 2740934 - RNA polymerase sigma-54 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. sigma-54 factors consist of three distinct regions: A conserved N-terminal glutamine-rich region (50 aa) that contains a potential leucine zipper motif. A region which is not conserved. A conserved C-terminal region (350 aa) that contains a second potential leucine zipper%2C a potential DNA-binding 'helix-turn-helix' motif and a perfectly conserved octapeptide whose function is not known%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2338 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2338 ZOBELLIA_2339 ZOBELLIA_2339 AsnS AsnS 2740983 2742416 - Asparaginyl-tRNA synthetase AsparaginyltRNA synthetase catalyse the attachment of the aminoacid asparagine to the 3'-hydroxyl of the tRNA. It is an homodimer%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2339 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2339 ZOBELLIA_234 ZOBELLIA_234 ZOBELLIA_234 288677 289540 - Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Contains a N-terminal haloalkane dehalogenase domain%3B Belongs to alpha/beta hydrolase superfamily%2C dmpD/todF/xylF esterase family%3B Localized in the cytoplasm%3B~Function unclear gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_234 ZOBELLIA_2340 ZOBELLIA_2340 acrB acrB 2742495 2744891 - Acriflavin resistance protein The acrA and acrB genes encode a multi-drug efflux system that is believed to protect the bacterium against hydrophobic inhibitors%3B Integral cytoplasmic membrane protein which contains 12 transmembrane helices and two sterol-sensing domains (SSD)%3B~Family membership gene gene2340 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2340 ZOBELLIA_2341 ZOBELLIA_2341 rrfA rrfA 2745027 2745581 - Ribosome recycling factor The ribosome recycling factor dissociates ribosomes from mRNA after termination of translation%2C and is essential for bacterial growth. Thus ribosomes are 'recycled' and ready for another round of protein synthesis%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2341 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2341 ZOBELLIA_2342 ZOBELLIA_2342 pyrH pyrH 2745626 2746333 - Uridylate kinase Uridylate kinase%2C also called UMP kinase%2C converts UMP to UDP by adding a phosphate from ATP. It is the first step in pyrimidine biosynthesis. GTP is an allosteric activator%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2342 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2342 ZOBELLIA_2343 ZOBELLIA_2343 ZOBELLIA_2343 2746514 2748382 + Glycyl aminopeptidase%2C family M61 Glycyl aminopeptidase is a metallopeptidase that encompasses a N-terminal catalytic domain and a C-terminal PDZ domain. Its primary function is thought to be in the degradation of extracellular proteins%2C enabling the efficient uptake of essential amino acids. PDZ domain binds either the carboxyl-terminal sequences of proteins or internal peptide sequences%3B Belongs to the M61 family of peptidases%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the cytoplasmic and/or outer membrane%3B~Specificity unclear gene gene2343 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2343 ZOBELLIA_2344 ZOBELLIA_2344 tsfA tsfA 2748528 2749493 - Elongation factor Ts (EF-Ts) The elongation factor Ts or EF-Ts functions in chain elongation during polypeptide synthesis by the ribosome. EF-Ts is a nucleotide exchange factor that is required to regenerate EF-Tu from its inactive form (EF-Tu- GDP) to its active form (EF-Tu-GTP). EF-Tu is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF-Ts remains bound to the aminoacyl-tRNA-EF-Tu-GTP complex up to the GTP hydrolysis stage on the ribosome. EF- Ts binds to the EF-Tu-GDP complex and induces the exchange of GDP to GTP%3B Belongs to the EF-Ts family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2344 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2344 ZOBELLIA_2345 ZOBELLIA_2345 rpsB rpsB 2749603 2750676 - Ribosomal protein S2 The ribosomal protein S2 is a part of the ribosomal small subunit (30S) that contributes to the structural integrity of the ribosome%3B Belongs to the ribosomal protein S2p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2345 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2345 ZOBELLIA_2346 ZOBELLIA_2346 rpsI rpsI 2750936 2751322 - Ribosomal protein S9 The ribosomal protein S9 is a part of the ribosomal small subunit (30S) that contributes to the structural integrity of the ribosome%3B Belongs to the ribosomal protein S9p/S16e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2346 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2346 ZOBELLIA_2347 ZOBELLIA_2347 rplM rplM 2751322 2751777 - Ribosomal protein L13 The ribosomal protein L13 is a part of the ribosomal large subunit (50S) that contributes to the structural integrity of the 50S ribosomal subunit%3B L13 is known to be one of the early assembly proteins of the 50S ribosomal subunit. It is important during the early stages of 50S assembly%3B Belongs to the ribosomal protein L13p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2347 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2347 ZOBELLIA_2348 ZOBELLIA_2348 ZOBELLIA_2348 2752143 2752490 - Hypothetical membrane protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Hypothetical protein gene gene2348 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2348 ZOBELLIA_2349 ZOBELLIA_2349 polA polA 2752593 2755424 - DNA polymerase I (POL I) Pol I is responsible for the replication of the late strand during DNA replication. Pol I exhibits a 3' to 5' (Exo II activity) and a 5' to 3' (Exo VI activity) exonuclease activities. The polymerase and Exo VI activities allow to fill the gaps present between the Okasaki's fragments. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. Pol I also is involved in the DNA repair%3B Belongs to the family A of DNA polymerases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2349 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2349 ZOBELLIA_235 ZOBELLIA_235 ZOBELLIA_235 289728 290291 - TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_235 ZOBELLIA_2350 ZOBELLIA_2350 aspG aspG 2755483 2756472 - Glycosylasparaginases 2 Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins%3B Protein exported in the periplasmic space%3B Protein contains a Twin-arginine translocation pathway signal that does not use the standard general secretory (Sec) pathway%3B Heterodimer of an alpha and a beta chain%3B~High confidence in function and specificity gene gene2350 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2350 ZOBELLIA_2351 ZOBELLIA_2351 cutC cutC 2756537 2757259 + Copper homeostasis protein Uncharacterized protein involved in copper homeostasis and in copper resistance%3B Belongs to the cutC family%3B Localized in the cytoplasm%3B~Function unclear gene gene2351 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2351 ZOBELLIA_2352 ZOBELLIA_2352 ZOBELLIA_2352 2757308 2758531 + Metallophosphoesterase Protein that catalyzes the hydrolysis of any phospho ester bond%3B Contains four transmembrane segments%3B Binds 2 divalent metal cations%3B Belongs to the metallophosphoesterase superfamily%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2352 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2352 ZOBELLIA_2353 ZOBELLIA_2353 trxA trxA 2758628 2758924 + Thioredoxin like protein Thioredoxins are small enzymes that participate in redox reactions%2C via the reversible oxidation of an active centre disulfide bond%3B In this protein%2C the catalytic cysteins are replaced by an asparagine and by a serine%3B~Family membership gene gene2353 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2353 ZOBELLIA_2354 ZOBELLIA_2354 ZOBELLIA_2354 2759056 2762442 - Conserved hypothetical membrane protein Contains 13 transmembrane segments%3B Integral cytoplasmic membrane protein%3B~Conserved hypothetical protein gene gene2354 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2354 ZOBELLIA_2356 ZOBELLIA_2356 nhaC nhaC 2762858 2764225 - Sodium/hydrogen exchanger The Sodium/hydrogen exchanger regulates the cytoplasmic pH%2C extruding the H+ generated during metabolism. It is involved also in the regulation of cell volume and in salt tolerance%2C due to Na+ uptake%3B Contains 13 transmembrane segmemts and a large cytoplasmic region at the carboxyl terminus%3B Belongs to the Na(+)/H(+) exchanger family%3B Integral cytoplasmic membrane protein%3B~Family membership gene gene2356 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2356 ZOBELLIA_2357 ZOBELLIA_2357 ZOBELLIA_2357 2764418 2764879 + Conserved hypothetical protein Protein that would associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events as mRNA degradation%3B Contains a domain of unknown function 150 (DUF 150)%3B Could belong to the Sm_like Superfamily%3B Localized in the Cytoplasm gene gene2357 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2357 ZOBELLIA_2358 ZOBELLIA_2358 nusA nusA 2764896 2766128 + Transcription termination factor NusA NusA%2C or N utilisation substance protein A%2C is a bacterial transcription termination factor. It binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures%3B Contains the S1 and KH (type 1) RNA binding motives in the C-terminal part%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2358 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2358 ZOBELLIA_2359 ZOBELLIA_2359 infB infB 2766251 2769112 + Translation initiation factor 2 IF-2 is one of the three factors required for the initiation of protein synthesis in bacteria. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Contains a C-terminal GTP binding domain%3B Belongs to the IF-2 family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2359 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2359 ZOBELLIA_236 ZOBELLIA_236 cgkA cgkA 290722 292362 + Kappa-carrageenase%2C family GH16 Kappa-carrageenase Hydrolyses the 1%2C4-beta-D-galactosidic linkages in kappa-carrageenan giving the tetramer as the predominant product%3B Modular enzyme containing a N-terminal catalytic domain belonging to the family 16 of the glycoside hydrolases%2C a central Carbohydrate Binding Module of the family CBM16 and a C-terminal domain of unknown function%3B Signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space and possibly secreted in the outside medium%3B~High confidence in function and specificity gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_236 ZOBELLIA_2360 ZOBELLIA_2360 ZOBELLIA_2360 2769171 2769599 - conserved hypothetical protein The start methionine has been changed to obtain a signal peptide length more correct. the cleavage site is now between the residues 19 and 20%3B Putatively periplasmic protein gene gene2360 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2360 ZOBELLIA_2361 ZOBELLIA_2361 ZOBELLIA_2361 2769778 2771148 + Multiheme cytochrome c Protein that contains in the N-terminal region (51 to 149) a CytC domain (Cyt C2) and in the C-terminal region (278 to 417) a multiheme CytC (Cyt C552)%3B Contains two transmembrane segmemts%3B Signal peptide cleaved between residues 30 and 31%3B Belongs to the Class 1 cytochrome c family%2C subclass IA/ IB%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2361 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2361 ZOBELLIA_2362 ZOBELLIA_2362 hmoA hmoA 2771183 2774344 + Molybdopterin oxidoreductase%2C iron-sulfur binding subunit Ferredoxins are iron-sulphur proteins that mediate electron transfer in a range of metabolic reactions%3B Contains 4 4Fe-4S type ferredoxin domains and a putatif Twin-arginine translocation pathway signal%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2362 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2362 ZOBELLIA_2363 ZOBELLIA_2363 hmoB hmoB 2774378 2776129 + Molybdopterin oxidoreductase%2C membrane subunit Ferredoxins are iron-sulphur proteins that mediate electron transfer in a range of metabolic reactions%3B Contains 10 cytoplasmic transmembrane segmemts%3B Belongs to the nrfD family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2363 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2363 ZOBELLIA_2364 ZOBELLIA_2364 ZOBELLIA_2364 2776132 2776662 + Conserved hypothetical protein Contains two transmembrane segments%3B Localized in the cytoplasmic membrane gene gene2364 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2364 ZOBELLIA_2365 ZOBELLIA_2365 ZOBELLIA_2365 2776665 2777225 + Cytochrome C monohaem The protein contains a cytochrome oxydase domain in its C-terminal region (96 to 181)%3B Signal peptide cleaved between the residues 21 and 22%3B putatively localised in the outer membrane%3B~Family membership gene gene2365 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2365 ZOBELLIA_2366 ZOBELLIA_2366 ZOBELLIA_2366 2777242 2778570 + Conserved membrane protein Protein contains 10 transmembrane segmemts%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2366 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2366 ZOBELLIA_2367 ZOBELLIA_2367 coxM coxM 2778601 2779710 + Cytochrome c oxidase%2C subunit II Cytochrome c oxidase is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen catalyzing the reduction of oxygen to water%3B Subunit II (CO II) transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit I%3B Contains three transmembrane segmemts%3B Signal sequence cleaved between the residues 16 and 17%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2367 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2367 ZOBELLIA_2368 ZOBELLIA_2368 coxN coxN 2779777 2781606 + Cytochrome c oxidase%2C subunit I Cytochrome c oxidase is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen catalyzing the reduction of oxygen to water%3B Subunit I (CO I) is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred%2C via the copper A center of subunit II and a low-spin heme (heme a) of subunit 1%2C to the CuB-heme a3 (or heme o) bimetallic center of subunit 1%3B contains 12 transmembrane segmemts%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2368 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2368 ZOBELLIA_2369 ZOBELLIA_2369 ZOBELLIA_2369 2781764 2782585 + Conserved hypothetical protein Localized in the cytoplasm gene gene2369 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2369 ZOBELLIA_237 ZOBELLIA_237 ZOBELLIA_237 292495 294228 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_237 ZOBELLIA_2370 ZOBELLIA_2370 acxA acxA 2782607 2784871 - Acyl-coenzyme A oxidase Acyl-coA oxidase%2C with FAD cofactor%2C converts acyl-CoA into trans-2-enoyl-CoA%3B Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)%3B~Family membership gene gene2370 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2370 ZOBELLIA_2371 ZOBELLIA_2371 ruvB ruvB 2784991 2786013 + Holliday junction DNA helicase The RuvB protein makes up part of the RuvABC resolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein%3B Enzyme ATP-dependent%3B Forms a complex with ruvA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2371 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2371 ZOBELLIA_2372 ZOBELLIA_2372 ZOBELLIA_2372 2786015 2786935 + 4Fe-4S ferredoxin Ferredoxins are iron-sulphur proteins that mediate electron transfer in a range of metabolic reactions%3B Localized in the cytoplasm%3B~Family membership gene gene2372 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2372 ZOBELLIA_2373 ZOBELLIA_2373 ZOBELLIA_2373 2787058 2788383 + Major Facilitator Superfamily transporter Conserved transporter belonging to the Major Facilitator Superfamily. Features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene2374 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2373 ZOBELLIA_2374 ZOBELLIA_2374 ZOBELLIA_2374 2786987 2787079 - Putative protein Hypothetical protein gene gene2373 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2374 ZOBELLIA_2375 ZOBELLIA_2375 maeB maeB 2788497 2790794 + NADP-dependent malate dehydrogenase / Phosphate acetyl/butaryl transferase Bifunctional protein: Malic enzyme (N-terminal domain%2C 1 to 550) and Phosphate acetyl/butaryl transferase (C-terminal domain%2C 550 to 765)%3B~High confidence in function and specificity gene gene2375 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2375 ZOBELLIA_2376 ZOBELLIA_2376 ruvA ruvA 2790850 2791431 + Holliday junction DNA helicase RuvA forms a complex with RuvB%2C RuvA stimulates%2C in the presence of DNA%2C the weak ATPase activity of RuvB%3B RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing%3B RuvA consists of three distinct domains. The N-terminal domain has an oligonucleotide/oligosaccharide binding structure (OB-fold)%2C the middle part contains an HhH motif and the C-terminal domain plays a significant role in the ATP-dependent branch migration of the hetero-duplex through direct contact with RuvB making no interaction with DNA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2376 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2376 ZOBELLIA_2377 ZOBELLIA_2377 sprA sprA 2791437 2798612 + Conserved hypothetical periplasmic protein Signal peptide cleaved between the resedues 31 and 32%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2377 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2377 ZOBELLIA_2378 ZOBELLIA_2378 gcvH gcvH 2798758 2799138 + Glycine cleavage system%2C H protein The glycine cleavage system is composed of four proteins: P%2C T%2C L and H%3B The H protein shuttles the methylamine group of glycine from the P protein to the T protein%3B The H protein binds a single lipoic acid as cofactor covalently bound via a amide linkage to a lysine group%3B contains a lipoyl-binding domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2378 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2378 ZOBELLIA_2379 ZOBELLIA_2379 ZOBELLIA_2379 2799173 2799532 + Conserved hypothetical membrane protein Contains a VanZ domain and three transmembrane segmemts%3B Signal peptide cleaved between the residues 27 and 28%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2379 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2379 ZOBELLIA_238 ZOBELLIA_238 ZOBELLIA_238 294292 296313 - Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_238 ZOBELLIA_2380 ZOBELLIA_2380 tonB2 tonB2 2799586 2800290 + TonB protein TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Energy flows from the cytoplasmic membrane into the outer membrane via a complex consisting of TonB%2C ExbB and ExbD proteins which are anchored in the cytoplasmic membrane. TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates%3B Features a N-terminal transmembrane helix%3B Belongs to the TonB family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2380 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2380 ZOBELLIA_2381 ZOBELLIA_2381 cyoE/ctaB cyoE/ctaB 2800464 2801363 + Protoheme IX farnesyltransferase Protoheme IX farnesyltransferase%2C also called haeme O synthase%2C converts protoheme IX and farnesyl diphosphate to heme O%2C an intermediate in the biosynthesis of haeme A%3B Uses divalent cations such as magnesium or calcium as cofactor%3B Contains nine transmembrane segmemts%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2381 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2381 ZOBELLIA_2382 ZOBELLIA_2382 coxC/ctaE coxC/ctaE 2801368 2801949 + Cytochrome C oxidase subunit III Associates with subunits I%2C II and IV to form cytochrome c oxidase the terminal enzyme of the respiratory chain%3B The functional role of subunit III is not yet understood%3B Contains five transmembrane segmemts%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2382 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2382 ZOBELLIA_2383 ZOBELLIA_2383 cyoC cyoC 2802046 2803035 + Cytochrome O ubiquinol oxidase%2C subunit III Cytochrome O terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration%3B Heterooctamer of two A chains%2C two B chains%2C two C chains and two D chains%3B Contains five transmembrane segmemts%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2383 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2383 ZOBELLIA_2384 ZOBELLIA_2384 ZOBELLIA_2384 2803091 2803474 + Conserved hypothetical membrane protein Contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2384 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2384 ZOBELLIA_2385 ZOBELLIA_2385 ZOBELLIA_2385 2803573 2804214 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2385 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2385 ZOBELLIA_2386 ZOBELLIA_2386 ZOBELLIA_2386 2804241 2804963 + Conserved hypothetical membrane protein Protein that consists of a SCO1/SenC domain%3B Belongs to the SCO2/SenC family%3B Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2386 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2386 ZOBELLIA_2387 ZOBELLIA_2387 ZOBELLIA_2387 2804964 2805497 + conserved hypothetical protein The protein contains five transmembrane segmemts gene gene2387 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2387 ZOBELLIA_2388 ZOBELLIA_2388 ZOBELLIA_2388 2805536 2805769 + Putative membrane protein Contains two transmembrane segmemts%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2388 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2388 ZOBELLIA_2389 ZOBELLIA_2389 ZOBELLIA_2389 2805868 2807112 + ABC exporter%2C permease component ABC (ATP-binding cassette) membrane domain (subunit 1) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics%2C heavy metals or solvents across biological membranes%3B Contains four transmembrane segments%3B Belongs to the ABC transporter family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2389 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2389 ZOBELLIA_239 ZOBELLIA_239 ZOBELLIA_239 296342 297664 - Conserved hypothetical protein Protein distantly related to the glycoside hydrolases of the families GH37 and GH63 (clan GH-G)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_239 ZOBELLIA_2390 ZOBELLIA_2390 ZOBELLIA_2390 2807146 2808405 + ABC exporter%2C permease component ABC (ATP-binding cassette) membrane domain (subunit 2) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics%2C heavy metals or solvents across biological membranes%3B Contains four transmembrane segments%3B Belongs to the ABC transporter family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2390 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2390 ZOBELLIA_2391 ZOBELLIA_2391 ZOBELLIA_2391 2808469 2809581 + Membrane fusion protein The membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmic membrane by a N-terminal transmembrane region%3B belongs to the type I secretion system%3B~Family membership gene gene2391 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2391 ZOBELLIA_2392 ZOBELLIA_2392 ZOBELLIA_2392 2809691 2810395 + ABC exporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component of the ABC transporters%3B~Family membership gene gene2392 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2392 ZOBELLIA_2393 ZOBELLIA_2393 ZOBELLIA_2393 2810385 2811614 + ABC exporter%2C permease component ABC (ATP-binding cassette) membrane domain (subunit 1) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics%2C heavy metals or solvents across biological membranes%3B Contains four transmembrane segments%3B Belongs to the ABC transporter family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2393 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2393 ZOBELLIA_2394 ZOBELLIA_2394 ZOBELLIA_2394 2811616 2812878 + ABC exporter%2C permease component ABC (ATP-binding cassette) membrane domain (subunit 2) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics%2C heavy metals or solvents across biological membranes%3B Contains four transmembrane segments%3B Belongs to the ABC transporter family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2394 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2394 ZOBELLIA_2395 ZOBELLIA_2395 ZOBELLIA_2395 2812941 2814083 + Membrane fusion protein The membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmic membrane by a N-terminal transmembrane region%3B belongs to the type I secretion system%3B~Family membership gene gene2395 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2395 ZOBELLIA_2396 ZOBELLIA_2396 ZOBELLIA_2396 2814115 2815464 + Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion)%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Family membership gene gene2396 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2396 ZOBELLIA_2397 ZOBELLIA_2397 ZOBELLIA_2397 2815562 2816236 + Family M22 non-peptidase protein Hypothetical protein that belongs to the family 22 of the metallopeptidases (M22)%2C but lacks the two conserved catalytic histidines which bind the zinc ion%3B Localized in the cytoplasm%3B~Family membership gene gene2397 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2397 ZOBELLIA_2398 ZOBELLIA_2398 yggB yggB 2816241 2817077 - Mechanosensitive ion channel Small-conductance mechanosensitive channels (MscS) with three transmembrane segments%3B Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains a Phosphopantetheine attachment site (Prosite result)%3B~High confidence in function and specificity gene gene2398 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2398 ZOBELLIA_2399 ZOBELLIA_2399 ZOBELLIA_2399 2817306 2817506 - Conserved hypothetical protein Protein belonging to the DUF1458 (domain unknown function) family%3B Localized in the cytoplasm gene gene2399 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2399 ZOBELLIA_24 ZOBELLIA_24 ZOBELLIA_24 23196 26381 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (27-112) and the Plug module (129-240) acting as a channel gate%3B The signal peptide is cleaved between the residues 22 and 23%3B~Family membership gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_24 ZOBELLIA_240 ZOBELLIA_240 ZOBELLIA_240 297856 299319 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_240 ZOBELLIA_2400 ZOBELLIA_2400 nifU nifU 2817590 2818504 - NifU-like protein Some of the Nif proteins are specifically involved in the formation of the Fe-S cluster of nitrogenase and these are found in organisms that do not fix nitrogen%3B C-terminal domain%3B~Family membership gene gene2400 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2400 ZOBELLIA_2401 ZOBELLIA_2401 ZOBELLIA_2401 2818638 2819651 + Conserved hypothetical protein Features a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasm. gene gene2401 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2401 ZOBELLIA_2402 ZOBELLIA_2402 ZOBELLIA_2402 2819730 2820917 - Conserved hypothetical protein Possible lipoprotein localised in the outer membrane%3B Sequence signal cleaved between the residues 22 and 23%3B Contains a von Willebrand factor type A domain gene gene2402 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2402 ZOBELLIA_2403 ZOBELLIA_2403 ZOBELLIA_2403 2821166 2823121 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Signal peptide cleaved between the residues 22 and 23%3B Contains one transmembrane segmemt and five tetratrico peptide repeats (TPR)%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2403 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2403 ZOBELLIA_2404 ZOBELLIA_2404 ZOBELLIA_2404 2823150 2823878 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene2404 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2404 ZOBELLIA_2405 ZOBELLIA_2405 paaY paaY 2823905 2824414 + Phenylacetic acid degradation o-acetyltransferase PaaY is involved in the catabolism of phenylacetic acid. This protein belongs to the o-acetyltransferase family. Its features four tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which has been shown to fold as a left-handed parallel beta helix%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2405 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2405 ZOBELLIA_2406 ZOBELLIA_2406 fabD fabD 2824485 2825372 + Malonyl CoA-acyl carrier protein transacylase Malonyl CoA-acyl carrier protein transacylase is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein%3B~High confidence in function and specificity gene gene2406 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2406 ZOBELLIA_2407 ZOBELLIA_2407 ZOBELLIA_2407 2825524 2829228 + Conserved protein containing calx-beta domain Contains two repeats of the calx-motif in the N-terminal domain (residues 34 to 128 and 142 to 254)%3B The calx-motif is present as a tandem repeat in the cytoplasmic domains of Calx Na-Ca exchangers%2C which are used to expel calcium from cells%3B Signal peptide cleaved between the residues 35 and 36%3B Protein possibly localised in the outer membrane (PSORT result)%3B Contains the endopeptidase Clp signature (residues 310-321%3B Prosite result)%3B~Conserved hypothetical protein gene gene2407 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2407 ZOBELLIA_2408 ZOBELLIA_2408 ZOBELLIA_2408 2829237 2830220 + Conserved hypothetical protein Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasm. gene gene2408 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2408 ZOBELLIA_2409 ZOBELLIA_2409 ZOBELLIA_2409 2830230 2832167 + OmpA-like outer membrane protein This protein has a modular architecture consisting of a N-terminal domain of unknown function%2C a central beta-propeller domain with three WD40 repeats and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Function unclear gene gene2409 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2409 ZOBELLIA_241 ZOBELLIA_241 ZOBELLIA_241 299337 302444 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (43-117) and the Plug module (133-240) acting as a channel gate%3B The signal peptide is cleaved between the residues 25 and 26%3B~Family membership gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_241 ZOBELLIA_2410 ZOBELLIA_2410 ZOBELLIA_2410 2832197 2833450 - Manganese/fer transporter Protein that Belongs to the NRAMP family (resistance-associated macrophage protein)%3B This family of membrane proteins are divalent cation transporters%3B Contains 10 transmembrane segments%3B Possible peptide signal cleaved between the residues 24 and 25%3B localized in the cytoplasmic membrane%3B~Family membership gene gene2410 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2410 ZOBELLIA_2411 ZOBELLIA_2411 ZOBELLIA_2411 2833791 2836916 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (60-134)%2C a Plug module (150-256) acting as the channel gate%3B The signal peptide is cleaved between the residue 39 and 40%3B~Family membership gene gene2411 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2411 ZOBELLIA_2412 ZOBELLIA_2412 ZOBELLIA_2412 2836934 2838385 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Putatively localized in the outer membrane%3B~Family membership gene gene2412 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2412 ZOBELLIA_2413 ZOBELLIA_2413 ZOBELLIA_2413 2838578 2842009 + ASPIC and UnbV like protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in the bacteria Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several bacterial proteins. In integrins%2C the FG-GAP repeats are a important region for ligand binding%3B Contains a putatif lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Function unclear gene gene2413 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2413 ZOBELLIA_2414 ZOBELLIA_2414 sanA sanA 2842026 2842661 - Protein involved in barrier function of the cell envelope The SanA protein participates in the barrier function of the cell envelope and may be involved in Vancomycin resistance and in murein synthesis%3B Signal peptide of lipoprotein cleaved between the residues 22 and 23%3B localized in the outer membrane%3B~High confidence in function and specificity gene gene2414 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2414 ZOBELLIA_2415 ZOBELLIA_2415 ZOBELLIA_2415 2842712 2843011 - Hypothetical protein Putatively localized in the cytoplasm gene gene2415 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2415 ZOBELLIA_2416 ZOBELLIA_2416 ZOBELLIA_2416 2843519 2843743 + Putative protein Hypothetical protein gene gene2416 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2416 ZOBELLIA_2417 ZOBELLIA_2417 ZOBELLIA_2417 2843740 2862351 + Hypothetical protein Protein that contains in the N-terminal part%2C one cadherin like domain and in its C-terminal part%2C five PKD repeats. The PKD domains are present in the extracellular parts of proteins involved in interactions with other proteins or polysaccharides%3B Signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane gene gene2417 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2417 ZOBELLIA_2418 ZOBELLIA_2418 proA1 proA1 2862399 2863598 - Gamma-glutamyl phosphate reductase Gamma-glutamyl phosphate reductase (GPR) is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate: the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate%3B Belongs to the aldehyde dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2418 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2418 ZOBELLIA_2419 ZOBELLIA_2419 proB1 proB1 2863599 2864384 - Glutamate 5-kinase Glutamate 5-kinase catalyses the first step in the biosynthesis of proline: the ATP-dependent phosphorylation of glutamate to glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline%3B It belongs to the larger family of aspartokinases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2419 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2419 ZOBELLIA_242 ZOBELLIA_242 ZOBELLIA_242 302688 306872 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_242 ZOBELLIA_2420 ZOBELLIA_2420 proC1 proC1 2864377 2865192 - Pyrroline-5-carboxylate reductase Delta 1-pyrroline-5-carboxylate reductase (P5CR) is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate: the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2420 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2420 ZOBELLIA_2421 ZOBELLIA_2421 ZOBELLIA_2421 2865247 2865438 - Putative membrane protein Contains a N-terminal transmembrane segment%3B Possibly localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2421 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2421 ZOBELLIA_2422 ZOBELLIA_2422 ZOBELLIA_2422 2866266 2866637 - Hypothetical membrane protein Possible lipoprotein with a signal peptide cleaved between the residues 18 and 19%3B Probably localized in the outer membrane%3B~Hypothetical protein gene gene2422 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2422 ZOBELLIA_2423 ZOBELLIA_2423 ZOBELLIA_2423 2866792 2867412 - Hypothetical membrane protein Signal peptide cleaved between the residues 19 and 20%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene2423 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2423 ZOBELLIA_2424 ZOBELLIA_2424 ZOBELLIA_2424 2867611 2868810 - Hypothetical protein Hypothetical protein possibly localized in the cytoplasm gene gene2424 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2424 ZOBELLIA_2426 ZOBELLIA_2426 ZOBELLIA_2426 2869448 2869741 - Hypothetical membrane protein Contains a transmembrane segment%3B Probably localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2426 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2426 ZOBELLIA_2427 ZOBELLIA_2427 ZOBELLIA_2427 2869716 2870978 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene2427 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2427 ZOBELLIA_2428 ZOBELLIA_2428 ZOBELLIA_2428 2871000 2872601 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B localized in the outer membrane and/or cytoplasmic membrane%3B~Specificity unclear gene gene2428 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2428 ZOBELLIA_2429 ZOBELLIA_2429 ZOBELLIA_2429 2872611 2874524 - Alpha-glucosidase%2C family GH97 Alpha-glucosidases Catalyse the hydrolysis of terminal%2C non-reducing 1%2C4-linked alpha-D-glucose residues with release of alpha-D-glucose. Involved in carbohydrate metabolism%2C notably in starch degradation%3B Belongs to the family 97 of glycoside hydrolases (GH97)%3B Lipoprotein signal peptide cleaved between the residues 21 and 22%3B Probably localized in the outer membrane%3B~High confidence in function and specificity gene gene2429 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2429 ZOBELLIA_243 ZOBELLIA_243 ZOBELLIA_243 307298 307606 + Hypothetical protein Putatively localized in the cytoplasm. gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_243 ZOBELLIA_2430 ZOBELLIA_2430 ZOBELLIA_2430 2874542 2876122 - Sulfatase%2C family S1-15 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 15%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic or/and outer membrane%3B~Family membership gene gene2430 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2430 ZOBELLIA_2431 ZOBELLIA_2431 lamA lamA 2876504 2877655 - Endo-1%2C3-beta-glucanase%2C family GH16 Endo-1%2C3-beta-glucanase (Laminarinase) hydrolyzes the 1%2C3-beta-D-glucosidic linkages in 1%2C3-beta-D-glucans. This laminarinase is a modular protein with a N-terminal PKD domain and a C-terminal catalytic module of the family 16 of glycoside hydrolases (GH16). Features a signal peptide of lipoprotein putatively cleaved between the residues 30 and 31%3B Localized in the outer membrane.%3B~High confidence in function and specificity gene gene2431 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2431 ZOBELLIA_2432 ZOBELLIA_2432 ZOBELLIA_2432 2877730 2879385 - Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2432 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2432 ZOBELLIA_2433 ZOBELLIA_2433 ZOBELLIA_2433 2879416 2881032 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 25 and 26%3B Putatively localized in the cytoplasmic membrane%3B~Family membership gene gene2433 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2433 ZOBELLIA_2434 ZOBELLIA_2434 ZOBELLIA_2434 2881042 2884011 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (22-95) and the Plug module (111-219) acting as a channel gate%3B Seems to possess a lipoprotein signal peptide is cleaved between the residues 16 and 17%3B~Family membership gene gene2434 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2434 ZOBELLIA_2435 ZOBELLIA_2435 ZOBELLIA_2435 2884285 2887080 - Ligand-binding sensor protein Protein that consists of an N-terminal periplasmic beta-propeller followed by a C-terminal cytoplasmic domain containing a LuxR-type HTH domain acting as transcrptionnal regulator. A transmembrane segment is present between these two domains. Signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2435 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2435 ZOBELLIA_2438 ZOBELLIA_2438 mutS1 mutS1 2887711 2890332 - DNA mismatch repair protein MutS The protein MutS is involved in the repair of mismatches in DNA. It plays a key role in the recognition and repair of errors made during the replication of DNA. This protein has a weak ATPase activity%3B Belongs to the MutS family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2438 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2438 ZOBELLIA_2439 ZOBELLIA_2439 ZOBELLIA_2439 2890492 2891031 + tRNA/rRNA methyltransferase Catalyzes the site-specific methylation of the 2' hydroxy group of the ribose in rRNA or tRNA%2C using the S-AdoMet%3B Contains a N-terminal RNA 2'-O ribose methyltransferase substrate binding domain and a C-terminal catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold%3B Belongs to the RNA methyltransferase TrmH family%3B Localized in the cytoplasm%3B~Family membership gene gene2439 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2439 ZOBELLIA_244 ZOBELLIA_244 rnrA2 rnrA2 307816 309600 - Ribonucleoside-diphosphate reductase%2C large subunit The large subunit of the ribonucleoside-diphosphate reductase%2C is a part of a complex which is an heterotetramer of two large and two small subunits. The complex catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_244 ZOBELLIA_2440 ZOBELLIA_2440 folK / dgkA2 folK / dgkA2 2891028 2892212 - 7%2C8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase / Deoxyguanosine kinase Modular protein with a N-terminal 7%2C8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) domain and a C-terminal Deoxyguanosine kinase (DGK) domain. HPPK catalyzes the attachment of pyrophosphate to 6-hydroxymethyl-7%2C8-dihydropterin to form 6-hydroxymethyl- 7%2C 8-dihydropteridine pyrophosphate. This is the first step in a three-step pathway leading to 7%2C8 dihydrofolate. Deoxyguanosine kinase DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors%2C dGTP and dATP%2C for DNA metabolism. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2440 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2440 ZOBELLIA_2441 ZOBELLIA_2441 sppA sppA 2892245 2894008 + Signal peptide peptidase A%2C family S49 Signal peptide peptidase A catalyzes the digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane. Forms a homotetramer. Belongs to the family 49 of the serine peptidases. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2441 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2441 ZOBELLIA_2442 ZOBELLIA_2442 ZOBELLIA_2442 2894083 2896182 - OmpA-like periplasmic protein This protein has a modular architecture consisting of a N-terminal domain of unknown function followed by four Thrombospondin type 3 repeats and a C-terminal OmpA- like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane and/or periplasmic space%3B~Family membership gene gene2442 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2442 ZOBELLIA_2443 ZOBELLIA_2443 ZOBELLIA_2443 2896277 2896999 + Conserved hypothetical protein Conserved integral membrane protein belonging to the DUF165 family%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2443 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2443 ZOBELLIA_2444 ZOBELLIA_2444 ZOBELLIA_2444 2897164 2899893 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2444 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2444 ZOBELLIA_2445 ZOBELLIA_2445 ZOBELLIA_2445 2900986 2902500 + Conserved hypothetical protein Protein distantly related to the Auxin-responsive GH3-like proteins%3B Localized in the cytoplasm gene gene2446 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2445 ZOBELLIA_2446 ZOBELLIA_2446 ZOBELLIA_2446 2900114 2900992 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2445 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2446 ZOBELLIA_2447 ZOBELLIA_2447 ZOBELLIA_2447 2902575 2903138 + Conserved hypothetical protein Localized in the cytoplasm. gene gene2447 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2447 ZOBELLIA_2448 ZOBELLIA_2448 clpX clpX 2903263 2904498 - Endopeptidase Clp%2C ATP-binding subunit Endopeptidase Clp plays a major role in the degradation of misfolded proteins. It is an oligomeric complex constituted by an ATP-binding subunit and a peptidase subunit (ClpP). The subunits form two different ring structures consisting of seven peptidase subunits and six ATP-binding subunits%2C respectively. ClpX directs the peptidase subunit ClpP to specific substrates. In the absence of ClpP%2C ClpX is a molecular chaperone%3B Belongs to the Hsp100 family and to AAA ATPases family%3B Contains a N-terminal C4-type zinc binding domain (ZBD) involved in substrate recognition%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2448 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2448 ZOBELLIA_2449 ZOBELLIA_2449 clpP1 clpP1 2904596 2905348 - Endopeptidase Clp%2C peptidase subunit%2C family S14 Endopeptidase Clp plays a major role in the degradation of misfolded proteins. It is an oligomeric complex constituted by an ATP-binding subunit (ClpX) and a peptidase subunit (ClpP). The subunits form two different ring structures consisting of seven peptidase subunits and six ATP-binding subunits%2C respectively. In absence of ClpX%2C ClpP can act only on oligopeptides%3B Belongs to the family S14 of the peptidases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2449 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2449 ZOBELLIA_245 ZOBELLIA_245 rnrB2 rnrB2 309601 310875 - Ribonucleoside-diphosphate reductase%2C small subunit The small subunit of the ribonucleoside-diphosphate reductase is a part of a complex which is an heterotetramer of two large and two small subunits. The complex catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides%3B Contains a N- terminal evolutionarily mobile%2C ATP-binding regulatory domain (ATP cone domain) which binds either ATP (activating) or dATP (inhibitory). Substrate binding to the ATP cone domain is thought to alter the relative positions of the two subunits of ribonucleoside- diphosphate reductase%3B Binds two iron ions by subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_245 ZOBELLIA_2450 ZOBELLIA_2450 tigA tigA 2905379 2906701 - Trigger factor Trigger factor (TF) is involved in protein export. It acts as an ATP-independent chaperone by binding to nascent polypeptide chains via ribosomal protein L23 (RplE) and maintaining the newly synthesized protein in an open conformation. Trigger Factor also displays a peptidyl-prolyl-cis-trans-isomerase (PPIase) activity in vitro. TF is composed of an N-terminal domain that mediates association with the large ribosomal subunit%2C a central substrate binding and PPIase domain with homology to FKBP proteins%2C and a C-terminal domain of unknown function. TF forms homodimer and monomer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2450 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2450 ZOBELLIA_2451 ZOBELLIA_2451 ZOBELLIA_2451 2906798 2907148 - Conserved hypothetical protein Conserved membrane protein belonging to the DUF360 family. Contains four transmembrane helices%3B Localized in the cytoplasmic membrane gene gene2451 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2451 ZOBELLIA_2452 ZOBELLIA_2452 ZOBELLIA_2452 2907262 2908032 - Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene2452 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2452 ZOBELLIA_2453 ZOBELLIA_2453 pdxJ pdxJ 2908033 2908746 - Pyridoxine 5'-phosphate synthase Pyridoxine 5'-phosphate synthase catalyzes the condensation between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP)%2C the active form of vitamin B6 used as coenzyme in a multitude of reactions%2C including decarboxylation%2C deamination and transamination%3B Belongs to the PNP synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2453 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2453 ZOBELLIA_2454 ZOBELLIA_2454 ZOBELLIA_2454 2908840 2909496 + CBS domain protein Contains a N-terminal CBS (cystathionine-beta-synthase) pair domain that can act as binding domains for adenosine derivatives such as AMP%2C ATP and S-AdoMet CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands%3B Localized in the cytoplasm%3B~Function unclear gene gene2454 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2454 ZOBELLIA_2455 ZOBELLIA_2455 ppnK ppnK 2909599 2910480 + NAD(+) kinase The inorganic polyphosphate/ATP-NAD kinase or NAD(+) kinase catalyzes the phosphorylation of NAD to NADP using ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus%3B Belongs to the NAD kinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2455 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2455 ZOBELLIA_2456 ZOBELLIA_2456 ZOBELLIA_2456 2910582 2911280 + Conserved hypothetical protein Signal peptide possibly cleaved between the residues 18 and 19%3B Putatively localized in the outer membrane gene gene2456 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2456 ZOBELLIA_2457 ZOBELLIA_2457 uppS uppS 2911458 2912198 + Undecaprenyl pyrophosphate synthetase Undecaprenyl pyrophosphate synthetase (UPP synthetase) generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide%3B Belongs to the UPP synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2457 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2457 ZOBELLIA_2458 ZOBELLIA_2458 ZOBELLIA_2458 2912203 2914815 + Outer membrane protein insertion porin (OmpIP) family This membrane protein seems involved in the insertion of outer membrane proteins. It has two domains. The C-terminal part%2C a beta-barrel pore-forming region inserted in the outer membrane%2C is a Bacterial surface antigen (D15) domain. The N-terminal part%2C exposed in the periplasm%2C and involved in gating of the pore and binding of the substrate proteins consists of four Surface antigen variable number repeats%3B Belongs to the surface antigen D15 family%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Family membership gene gene2458 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2458 ZOBELLIA_2459 ZOBELLIA_2459 ZOBELLIA_2459 2914907 2915728 + Outer membrane chaperone Skp (OmpH) family Protein belonging to the skp family%3B Skp (OmpH) is a homotrimeric periplasmic chaperone for newly synthesised outer membrane proteins as they emerge in the periplasm from the Sec translocation machinery%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Family membership gene gene2459 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2459 ZOBELLIA_246 ZOBELLIA_246 ZOBELLIA_246 311419 311511 - Putative protein Hypothetical protein gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_246 ZOBELLIA_2460 ZOBELLIA_2460 hlpA hlpA 2915872 2916381 + Molecular chaperone Skp Homotrimeric molecular chaperone that interacts specifically with newly synthesised outer membrane proteins as they emerge in the periplasm from the Sec translocation machinery%2C thus maintaining the solubility of early folding intermediates during passage through the periplasm%3B Skp must interact directly with membrane lipids and lipopolysaccharide for an efficient Skp-assisted folding of membrane proteins%3B Belongs to the skp family%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2460 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2460 ZOBELLIA_2461 ZOBELLIA_2461 ZOBELLIA_2461 2917675 2917938 + Pseudogene This protein corresponds to the N-terminal region of a transposase (mutator family) and is likely inactive. Localized in the cytoplasm.%3B~Function unclear pseudogene gene2461 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2461 ZOBELLIA_2462 ZOBELLIA_2462 ZOBELLIA_2462 2917959 2918867 + Pseudogene This protein corresponds to the C-terminal region of a transposase (mutator family) and is likely inactive. Localized in the cytoplasm.%3B~Function unclear pseudogene gene2462 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2462 ZOBELLIA_2463 ZOBELLIA_2463 ZOBELLIA_2463 2918922 2919719 - Hypothetical lipoprotein Protein containing a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Hypothetical protein gene gene2463 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2463 ZOBELLIA_2464 ZOBELLIA_2464 ZOBELLIA_2464 2919820 2920686 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases (GT2)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2464 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2464 ZOBELLIA_2465 ZOBELLIA_2465 ZOBELLIA_2465 2920728 2921297 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2465 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2465 ZOBELLIA_2466 ZOBELLIA_2466 fabH3 fabH3 2921308 2922363 - 3-oxoacyl-[acyl-carrier-protein] synthase III 3-oxoacyl-[acyl-carrier-protein] synthase III%2C also known as beta-ketoacyl-ACP synthase III%2C catalyses the reaction: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] %3D 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. This is the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain. Negatively regulated by acyl-ACP%2C possibly by binding to either the free enzyme or the acyl-enzyme intermediate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2466 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2466 ZOBELLIA_2467 ZOBELLIA_2467 gcvP gcvP 2922530 2925382 - Glycine cleavage system%2C protein P component The P protein is the Glycine dehydrogenase [decarboxylating] of the glycine decarboxylase multienzyme complex. This glycine cleavage system%2C induced By glycine%2C catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor (Vitamin B6)%2C carbon dioxide is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2467 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2467 ZOBELLIA_2468 ZOBELLIA_2468 ZOBELLIA_2468 2925508 2926332 + conserved hypothetical membrane protein Contains nine transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2468 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2468 ZOBELLIA_2469 ZOBELLIA_2469 ZOBELLIA_2469 2926329 2926556 - Conserved hypothetical protein Localized in the cytoplasm gene gene2469 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2469 ZOBELLIA_247 ZOBELLIA_247 ZOBELLIA_247 311805 314891 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (55-128) and the Plug module (144-260) acting as a channel gate%3B The signal peptide is cleaved between the residues 30 and 31%3B~Family membership gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_247 ZOBELLIA_2470 ZOBELLIA_2470 ZOBELLIA_2470 2926559 2927203 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B Belongs to the sigma-70 factor family%2C ECF subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene2470 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2470 ZOBELLIA_2471 ZOBELLIA_2471 glpE3 glpE3 2927234 2927590 + Thiosulfate sulfurtransferase Thiosulfate sulfurtransferase catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate%3B Contains one only rhodanese domain%3B Lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene2471 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2471 ZOBELLIA_2472 ZOBELLIA_2472 ZOBELLIA_2472 2927587 2928108 - 5'(3')-Deoxyribonucleotidase 5'(3')-deoxyribonucleotidase dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides%2C with a preference for dUMP and dTMP%2C an intermediate activity towards dGMP%2C and a low activity towards dCMP and dAMP%3B Uses the magnesium as cofactor%3B Belongs to the 5'(3')-deoxyribonucleotidase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2472 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2472 ZOBELLIA_2473 ZOBELLIA_2473 prlC prlC 2928356 2930374 - Oligopeptidase A%2C family M3 Oligopeptidase A catalyzes the hydrolysis of oligopeptides%2C with broad specificity. Gly or Ala commonly occur as P1 or P1' residues%2C but more distant residues are also important%2C as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved%2C but not Z-(Gly)5. Belongs to the family 3 of the metallopeptidases. It contains a conserved HEXXH motif that forms the active site in conjunction with a C-terminally-located Glu residue. A single zinc ion is ligated by the sidechains of the two His residues%2C and the more C-terminal Glu. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2473 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2473 ZOBELLIA_2474 ZOBELLIA_2474 ZOBELLIA_2474 2930397 2930798 - Hypothetical membrane protein Contains three transmembrane segments and one putative EF-hand domain invoved in the calcium ion binding%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2474 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2474 ZOBELLIA_2475 ZOBELLIA_2475 purE purE 2930830 2931321 - N5-(carboxyamino)imidazole ribonucleotide mutase The N5-(carboxyamino)imidazole ribonucleotide mutase converts N5-CAIR (N5-carboxyaminoimidazole ribonucleotide) to CAIR%2C the sixth step of de novo purine biosynthesis. In the presence of high concentrations of bicarbonate%2C PurE is able to convert AIR to CAIR directly and without ATP%2C but in association with PurK%2C which possesses an ATPase activity%2C an enzymatic complex called Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) is produced%2C converting AIR to CAIR efficiently under physiological condition%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2475 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2475 ZOBELLIA_2476 ZOBELLIA_2476 purK purK 2931326 2932498 - N5-carboxyaminoimidazole ribonucleotide synthetase The N5-carboxyaminoimidazole ribonucleotide (N5_CAIR) synthetase%2C catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR) to N5-CAIR%3B It possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of PurK with PurE produces an enzyme complex called Phosphoribosylaminoimidazole carboxylase (EC 4.1.1. 21) converting AIR to CAIR efficiently under physiological condition%3B Contains 1 ATP-grasp domain%3B Belongs to the PurK/PurT family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2476 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2476 ZOBELLIA_2477 ZOBELLIA_2477 hptA/adkA hptA/adkA 2932609 2933715 + Bifunctional protein Hypoxanthine-guanine phosphoribosyltransferase / Adenylate kinase Bifunctional protein that contains two modules. In the N-terminal part a Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) module%2C involved in the purine salvage%2C converts IMP to hypoxanthine and GMP to guanine. In the C-terminal part an Adenylate kinase module%2C involved in the energy metabolism and nucleotide synthesis%2C catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP to product 2 ADPs%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2477 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2477 ZOBELLIA_2478 ZOBELLIA_2478 obgA obgA 2933901 2934902 + GTP-binding protein Obg Essential GTP-binding proteinputatively involved in ribosomal biogenesis%3B Contains two equally and highly conserved domains%2C an N-terminal glycine-rich domaina and a C-terminal GTP binding domain%3B Belongs to the GTP1/OBG family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2478 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2478 ZOBELLIA_2479 ZOBELLIA_2479 ZOBELLIA_2479 2934970 2935491 + Conserved hypothetical lipoprotein Cotains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2479 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2479 ZOBELLIA_248 ZOBELLIA_248 ZOBELLIA_248 314940 316685 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 21 and 22%3B Probably localized in the outer membrane%3B~Family membership gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_248 ZOBELLIA_2480 ZOBELLIA_2480 ZOBELLIA_2480 2935686 2936051 + Hypothetical protein Localized in the cytoplasm. gene gene2480 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2480 ZOBELLIA_2481 ZOBELLIA_2481 ZOBELLIA_2481 2936065 2942115 - Conserved hypothetical protein Contains a putative uncleavable signal sequence gene gene2481 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2481 ZOBELLIA_2482 ZOBELLIA_2482 ZOBELLIA_2482 2942352 2943137 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene2482 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2482 ZOBELLIA_2483 ZOBELLIA_2483 ZOBELLIA_2483 2943172 2943546 - Conserved hypothetical protein Protein that could be involved in the glycan degradation pathways and have a role in pathogenicity%3B Contains an N-terminal transmembrane segment and a C-terminal Cupin domain%3B Semms localized in the cytoplasmic membrane%3B~Function unclear gene gene2483 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2483 ZOBELLIA_2484 ZOBELLIA_2484 ZOBELLIA_2484 2943628 2945772 - OmpA-like protein Modular protein consisting of a N-terminal domain of unknown function%2C a central beta-propeller domain%2C encompassing four WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space or outer membrane%3B~Function unclear gene gene2484 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2484 ZOBELLIA_2485 ZOBELLIA_2485 ZOBELLIA_2485 2945775 2946713 - Conserved hypothetical protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space gene gene2485 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2485 ZOBELLIA_2486 ZOBELLIA_2486 ZOBELLIA_2486 2946717 2949602 - Conserved hypothetical protein Signal peptide cleaved between the residues 28 and 29%3B Possibly localized in the outer membrane gene gene2486 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2486 ZOBELLIA_2487 ZOBELLIA_2487 mplA mplA 2949860 2951218 + UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase is an enzyme involved in the biosynthesis of peptidoglycan which reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid%3B Belongs to the MurCDEF family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2487 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2487 ZOBELLIA_2488 ZOBELLIA_2488 radC radC 2951328 2952026 + DNA repair protein RadC RadC plays a role in repair of DNA damage after UV and X-ray irradiation in prokaryotes%3B RadC may function specifically in recombinational repair that is associated with the replication fork. Involved in DNA repair%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2488 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2488 ZOBELLIA_2489 ZOBELLIA_2489 ZOBELLIA_2489 2952101 2953396 + Conserved hypothetical protein Localized in the cytoplasm gene gene2489 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2489 ZOBELLIA_249 ZOBELLIA_249 ZOBELLIA_249 316803 317873 + Conserved hypothetical protein Possibly localized in the cytoplasm gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_249 ZOBELLIA_2490 ZOBELLIA_2490 ZOBELLIA_2490 2953389 2954078 + 5'-nucleotidase Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates%2C UMP%2C dUMP%2C and dTMP%2C and very low activity against TDP%2C IMP%2C UDP%2C GMP%2C dGMP%2C AMP%2C dAMP%2C and 6-phosphogluconate. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles%3B Uses Divalent metal cation as cofactors. Highest activity with manganese followed by magnesium and cobalt%3B Belongs to the HAD-like hydrolase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2490 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2490 ZOBELLIA_2491 ZOBELLIA_2491 ZOBELLIA_2491 2954102 2954680 + Conserved hypothetical protein Seems to have an uncleavable N-terminal signal sequence%3B Putatively localized in the cytoplasmic membrane gene gene2491 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2491 ZOBELLIA_2492 ZOBELLIA_2492 ZOBELLIA_2492 2954677 2956107 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2492 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2492 ZOBELLIA_2493 ZOBELLIA_2493 ZOBELLIA_2493 2956222 2957070 + Conserved hypothetical protein Localized in the cytoplasm gene gene2493 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2493 ZOBELLIA_2494 ZOBELLIA_2494 ZOBELLIA_2494 2957067 2958344 - ATPase%2C AAA family Protein possibly involved in the DNA replication or DNA repair%3B Contains a N-terminal AAA ATPase domain that%2C in general%2C acts as ATP-dependent protein clamps%3B Belongs to the AAA ATPase family that performs chaperone-like functions that assist in the assembly%2C operation%2C or disassembly of protein complexes%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2494 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2494 ZOBELLIA_2495 ZOBELLIA_2495 ZOBELLIA_2495 2958489 2959244 + Rhomboid-like protease%2C family S54 This family of proteins contains serine peptidases belonging to the MEROPS peptidase family S54 (clan S)%3B They are integral membrane proteins involved in the cleavage of membrane proteins. It cleaves the transmembrane proteins within their transmembrane domains to release a soluble protein%3B Contains five transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2495 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2495 ZOBELLIA_2496 ZOBELLIA_2496 rlmB rlmB 2959266 2960012 - 23S rRNA (guanosine-2'-O-)-methyltransferase RmlB specifically methylates the 2' hydroxy group of the ribose of guanosine 2251 in 23S rRNA%2C using the S-AdoMet%3B Contains a N-terminal RNA 2'-O ribose methyltransferase substrate binding domain and a C-terminal catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold%3B Belongs to the RNA methyltransferase TrmH family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2496 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2496 ZOBELLIA_2497 ZOBELLIA_2497 ZOBELLIA_2497 2960148 2960921 - Hypothetical lipoprotein Contains a lipoporotein signal peptide cleaved between the residues 23 and 24%3B Possibly localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2497 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2497 ZOBELLIA_2498 ZOBELLIA_2498 ZOBELLIA_2498 2960933 2962441 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Family membership gene gene2498 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2498 ZOBELLIA_2499 ZOBELLIA_2499 ZOBELLIA_2499 2962448 2965546 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-98) and the Plug module (115-224) acting as a channel gate%3B The signal peptide is cleaved between the residues 22 and 23%3B~Family membership gene gene2499 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2499 ZOBELLIA_25 ZOBELLIA_25 rplI rplI 26469 26921 - Ribosomal protein L9 Ribosomal protein L9 is a protein from the large ribosomal subunit (50S)%2C known to bind directly very close to the 3' end of the 23S rRNA%3B Belongs to the ribosomal protein L9p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_25 ZOBELLIA_250 ZOBELLIA_250 ZOBELLIA_250 317879 319690 + Calcineurin-like phosphoesterase The exact specificity of this conserved phosphoesterase is not known%3B Belongs to the Calcineurin family%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_250 ZOBELLIA_2500 ZOBELLIA_2500 ZOBELLIA_2500 2965896 2966090 - Putative protein Hypothetical protein gene gene2500 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2500 ZOBELLIA_2501 ZOBELLIA_2501 ZOBELLIA_2501 2966479 2967654 - Hypothetical membrane protein Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Putatively adopts a beta-helix fold%3B Localized in the outer membrane%3B~Hypothetical protein gene gene2501 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2501 ZOBELLIA_2502 ZOBELLIA_2502 ZOBELLIA_2502 2967682 2969109 - Probable SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 16 and 17%3B Probably localized in the outer membrane%3B~Family membership gene gene2502 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2502 ZOBELLIA_2503 ZOBELLIA_2503 ZOBELLIA_2503 2969120 2972380 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-98) and the Plug module (115-241) acting as a channel gate%3B The signal peptide is cleaved between the residues 22 and 23%3B~Family membership gene gene2503 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2503 ZOBELLIA_2504 ZOBELLIA_2504 ZOBELLIA_2504 2972538 2972651 + Putative protein Hypothetical protein gene gene2504 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2504 ZOBELLIA_2505 ZOBELLIA_2505 ZOBELLIA_2505 2972760 2972894 + Putative membrane protein Contains a transmembrane segment%3B Possibly localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2505 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2505 ZOBELLIA_2506 ZOBELLIA_2506 rpsL rpsL 2972984 2973442 + Ribosomal protein S12 Ribosomal protein S12 is one of the proteins from the 30S ribosomal subunit involved in the translation initiation step%3B Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits%2C it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together%3B Bacterial S12 molecules contain a conserved aspartic acid residue which undergoes a post-translational beta-methylthiolation to form the corresponding 3-methylthioaspartic acid%3B Belongs to a family of ribosomal proteins S12p/S23e%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2506 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2506 ZOBELLIA_2507 ZOBELLIA_2507 rpsG rpsG 2973517 2973993 + Ribosomal protein S7 Ribosomal protein S7 is one of the proteins from the 30S ribosomal subunit known to bind directly to part of the 3'end of 16S ribosomal RNA where it nucleates assembly of the head domain of the 30S subunit. It is located at the subunit interface close to the decoding center%2C probably blocks exit of the E-site tRNA%3B Belongs to the ribosomal protein S7p/S5e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2507 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2507 ZOBELLIA_2508 ZOBELLIA_2508 fusA fusA 2974000 2976132 + Translation elongation factor G The Translation elongation factor G (EF-G) promotes the GTP-dependent translocation of the nascent protein chain from the A-site (acceptor site) to the P-site (peptidyl tRNA site) of the ribosome. EF-G also has a role after the termination phase of translation%2C where%2C together with the ribosomal recycling factor%2C it facilitates the release of tRNA and mRNA from the ribosome%2C and the splitting of the ribosome into two subunits%3B Belongs to the GTP-binding elongation factor family. EF-G/eEF-2 subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2508 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2508 ZOBELLIA_2509 ZOBELLIA_2509 rpsJ rpsJ 2976144 2976449 + Ribosomal protein S10 Ribosomal protein S10 is one of the proteins from the 30S ribosomal subunit known to be involved in binding tRNA to the ribosomes%3B S10 has virtually no groups exposed on the ribosomal surface%3B Belongs to a family of ribosomal proteins S10p/S20e%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2509 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2509 ZOBELLIA_251 ZOBELLIA_251 ZOBELLIA_251 319737 319883 + Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_251 ZOBELLIA_2510 ZOBELLIA_2510 rplC rplC 2976638 2977255 + Ribosomal protein L3 Ribosomal protein L3 is one of the proteins from the 50S ribosomal subunit known to bind to near the 3'end of the 23S rRNA where it nucleates assembly of the large ribosomal subunit and may participate in the formation of the peptidyltransferase center of the ribosome%3B Belongs to the ribosomal proteins L3p/L4e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2510 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2510 ZOBELLIA_2511 ZOBELLIA_2511 rplD rplD 2977255 2977884 + Ribosomal protein L4 One of the primary rRNA binding proteins%2C this protein initially binds near the 5' end of the 23S rRNA and makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. It is important during the early stages of 50S ribosomal subunit assembly and forms part of the polypeptide exit tunnel (E site)%3B Belongs to the ribosomal protein L4b/L1a/L1e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2511 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2511 ZOBELLIA_2512 ZOBELLIA_2512 rplW rplW 2977891 2978181 + Ribosomal protein L23 Ribosomal protein L23 is one of the proteins from the 50S ribosomal subunit that binds to a specific region on the 23S rRNA%3B Belongs to the ribosomal protein L23p/L25e%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2512 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2512 ZOBELLIA_2513 ZOBELLIA_2513 rplB rplB 2978191 2979015 + Ribosomal protein L2 Ribosomal protein L2 is one of the proteins from the 50S ribosomal subunit%3B The L2 protein is located near the peptidyl transferase centre where it may contribute to peptidyltransferase activity%2C and is involved in the assembly of the 23SrRNA%3B L2 is elongated%2C exposing one end of the protein to the surface of the intersubunit interface of the 50 S subunit and is required for association of the 30S and 50S subunits to form the 70S ribosome%3B Belongs to the ribosomal proteins L2p/L8e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2513 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2513 ZOBELLIA_2514 ZOBELLIA_2514 rpsS rpsS 2979030 2979308 + Ribosomal protein S19 Ribosomal protein S19 is one of the proteins from the 30S ribosomal subunit known to form a complex with S13 that binds strongly to 16S ribosomal RNA. Experimental evidence has revealed that S19 is moderately exposed on the ribosomal surface and is designated a secondary rRNA binding protein%3B Belongs to the ribosomal protein S19p/S15e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2514 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2514 ZOBELLIA_2515 ZOBELLIA_2515 rplV rplV 2979312 2979719 + Ribosomal protein L22 Ribosomal protein L22 is one of the proteins from the 50S ribosomal subunit known to bind all six domains of the 23S rRNA. Its binding is stimulated by other ribosomal proteins as L4%2C L17%2C and L20. It is important during the early stages of 50S assembly%3B The globular domain of the protein is located near the polypeptide exit tunnel (E site) on the outside of the subunit%2C while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome%3B Belongs to the ribosomal proteins L22p/L17e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2515 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2515 ZOBELLIA_2516 ZOBELLIA_2516 rpsC rpsC 2979721 2980443 + Ribosomal protein S3 Ribosomal protein S3 is one of the proteins from the 30S ribosomal subunit known to be involved in the binding of initiator Met-tRNA. It Binds the lower part of the 30S subunit head and the mRNA in the 70S ribosome. Forms a tight complex with proteins S10 and S14%3B Contains a type-2 KH domain that has been shown to bind RNA%3B Belongs to the ribosomal proteins S3p/S3e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2516 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2516 ZOBELLIA_2517 ZOBELLIA_2517 rplP rplP 2980463 2980894 + Ribosomal protein L16 Ribosomal protein L16 is one of the proteins from the 50S ribosomal subunit known to bind directly the 23S rRNA and to be located at the A site of the peptidyltransferase center%3B Belongs to the ribosomal protein L16b/L10a/L10e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2517 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2517 ZOBELLIA_2518 ZOBELLIA_2518 rpmC rpmC 2980903 2981094 + Ribosomal protein L29 Ribosomal protein L29 is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the 50S ribosomal subunit%3B Contacts protein L23%2C trigger factor and protein nascent chains%3B Belongs to the Ribosomal protein L29p/L35e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2518 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2518 ZOBELLIA_2519 ZOBELLIA_2519 rpsQ rpsQ 2981108 2981368 + Ribosomal protein S17 Ribosomal protein S17 is one of the primary rRNA binding protein from the 30S ribosomal subunit known to bind specifically to the 5' end of 16S ribosomal RNA and is thought to be involved in the recognition of termination codons. Experimental evidence has revealed that S17 has virtually no groups exposed on the ribosomal surface%3B Belongs to the ribosomal proteins S17p/S11e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2519 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2519 ZOBELLIA_252 ZOBELLIA_252 idnO3 idnO3 319895 320689 - Gluconate-5-dehydrogenase Also called 5-keto-D-gluconate 5-reductase%3B Catalyzes the nonphosphorylative%2C ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate using NADP as a coenzyme%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_252 ZOBELLIA_2520 ZOBELLIA_2520 rplN rplN 2981370 2981738 + Ribosomal protein L14 Ribosomal protein L14 is one of the proteins from the 50S ribosomal subunit known to bind directly to the 23S rRNA%3B Belongs to the ribosomal protein L14p/L23e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2520 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2520 ZOBELLIA_2521 ZOBELLIA_2521 rplX rplX 2981753 2982067 + Ribosomal protein L24 Ribosomal protein L24 is one of the proteins from the 50S ribosomal subunit. It is one of two assembly inititator proteins%2C it binds directly to the 5' end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit and surrounds the polypeptide exit tunnel on the outside of the subunit%3B Contains a N-terminal KOW (Kyrpides%2C Ouzounis%2C Woese) motif involved in nucleic acid interactions%3B Belongs to the ribosomal proteins L24p/L26e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2521 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2521 ZOBELLIA_2522 ZOBELLIA_2522 rplE rplE 2982071 2982622 + Ribosomal protein L5 Ribosomal protein L5 is one of the proteins from the 50S ribosomal subunit that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance. The 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs%3B In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b)%2C connecting the 2 subunits. This bridge is implicated in subunit movement%3B Contacts the P site tRNA%3B Belongs to the ribosomal proteins L5p/L11e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2522 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2522 ZOBELLIA_2523 ZOBELLIA_2523 rpsN rpsN 2982624 2982893 + Ribosomal protein S14 Ribosomal protein S14 is one of the proteins required for the assembly of the 30S ribosomal subunit and may also be responsible for determining the conformation of 16S rRNA at the A site (acceptor site)%3B Belongs to the ribosomal proteins S14p/S29e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2523 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2523 ZOBELLIA_2524 ZOBELLIA_2524 rpsH rpsH 2982960 2983358 + Ribosomal protein S8 Ribosomal protein S8 is one of the primary rRNA binding proteins from the 30S ribosomal subunit. It binds directly to 16S rRNA central domain where it helps to coordinate assembly of the platform of the small ribosomal subunit%3B Contacts proteins S5 and S12%3B Belongs to the ribosomal proteins S8p/S15e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2524 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2524 ZOBELLIA_2525 ZOBELLIA_2525 rplF rplF 2983377 2983919 + Ribosomal protein L6 Ribosomal protein L6 is one of the proteins from the 50S ribosomal subunit known to bind directly to the 23S rRNA and is located at the aminoacyl-tRNA binding site of the peptidyltransferase center%3B L6 comprises 2 almost identical domains%2C suggesting that is was derived by the duplication of an ancient RNA-binding protein gene%2C the N-terminus being involved in protein-protein interactions and the C-terminus containing possible RNA-binding sites%3B Belongs to the ribosomal proteins L6p/L9e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2525 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2525 ZOBELLIA_2526 ZOBELLIA_2526 rplR rplR 2983929 2984285 + Ribosomal protein L18 Ribosomal protein L18 is one of the proteins from the 50S ribosomal subunit that binds and probably mediates the attachment of the 5S rRNA into the large ribosomal subunit%2C where it forms part of the central protuberance. It increases binding abilities of L5 in a cooperative fashion%2C both proteins together confering 23S rRNA binding%3B The protein contains a phosphoserine which is required for the binding to 5S rRNA (possibly on Ser55)%3B Belongs to the ribosomal protein L18p/L5e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2526 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2526 ZOBELLIA_2527 ZOBELLIA_2527 rpsE rpsE 2984294 2984818 + Ribosomal protein S5 Ribosomal protein S5 is one of the proteins important in the assembly and function of the 30S ribosomal subunit. It is Located at the back of the small subunit body where it stabilizes the conformation of the head with respect to the body. The N-terminal domain interacts with the head of the 30S subunit%2C the C-terminal domain interacts with the body and contacts protein S4. With S4 and S12%2C S5 plays an important role in translational accuracy and the interaction surface between S4 and S5 is involved in control of translational fidelity%3B Contains a S5 double strand rRNA domain (dsRBD) that interacts with the 16S rRNA%3B Belongs to the ribosomal proteins S5p/S2e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2527 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2527 ZOBELLIA_2528 ZOBELLIA_2528 rpmD rpmD 2984830 2985012 + Ribosomal protein L30 Ribosomal protein L30 is Localized near the guanosine triphosphatase center of the 50S subunit%3B Belongs to the ribosomal proteins L30p/L7e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2528 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2528 ZOBELLIA_2529 ZOBELLIA_2529 rplO rplO 2985026 2985478 + Ribosomal protein L15 Ribosomal protein L15 is one of the proteins from the 50S ribosomal subunit known to bind the 23S rRNA. Belongs to the ribosomal proteins L15p/L27Ae family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2529 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2529 ZOBELLIA_253 ZOBELLIA_253 ZOBELLIA_253 320793 322973 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains 13 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene253 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_253 ZOBELLIA_2530 ZOBELLIA_2530 secY secY 2985491 2986834 + Preprotein translocase%2C SecY subunit SecY is one of seven secretory proteins (secA-F and secY) that comprise the prokaryotic protein translocation apparatus (translocase)%3B Interacts with secA and secE to allow the translocation of proteins across the cytoplasmic membrane%2C by forming part of a channel%3B Contains 10 transmembrane segments%2C 6 cytoplasmic and 5 periplasmic regions%3B Belongs to the secY/SEC61-alpha family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2530 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2530 ZOBELLIA_2531 ZOBELLIA_2531 infA infA 2986837 2987052 + Translation initiation factor IF-1 The initiation factor IF-1 seems to stimulate more or less all the activities of the other two initiation factors%2C IF-2 and IF-3. Seems stabilizes the 30S ribosomal subunit by binding to the A site. This binding may modulate subunit association and the fidelity of tRNA section in the P site through conformational changes in the 16S rRNA%3B Contains 1 S1-like domain found in a large number of RNA-associated proteins%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2531 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2531 ZOBELLIA_2532 ZOBELLIA_2532 rpsM rpsM 2987196 2987570 + Ribosomal protein S13 Ribosomal protein S13 is involved in binding fMet-tRNA. It is located at the top of the head of the 30S subunit and contacts several helices of the 16S rRNA by an N-terminal helix-two turns-helix (H2TH) domain. In the 70S ribosome%2C S13 contacts the 23S rRNA (bridge B1a) and protein L5 (bridge B1b)%2C connecting the 2 subunits. These bridges are implicated in subunit movement%3B Forms a loose heterodimer with protein S19%3B Belongs to the ribosomal protein S13p/S18e%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2532 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2532 ZOBELLIA_2533 ZOBELLIA_2533 rpsK rpsK 2987583 2987987 + Ribosomal protein S11 Ribosomal protein S11 is located on the large lobe of the 30S ribosomal subunit known to plays an essential role in selecting the correct tRNA in protein biosynthesis%3B S11 bridges several disparate RNA helices of the 16S rRNA%2C forms part of the Shine-Dalgarno cleft in the 70S ribosome%2C interacts with proteins S7 and S18 and binds to IF-3%3B Belongs to the ribosomal proteins S11p/S14e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2533 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2533 ZOBELLIA_2534 ZOBELLIA_2534 rpsD rpsD 2988076 2988681 + Ribosomal protein S4 Ribosomal protein S4 is one of the primary rRNA binding proteins from the 30S ribosomal subunit known to bind directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12%2C S4 plays an important role in translational accuracy. The interaction surface between S4 and S5 is involved in control of translational fidelity%3B Belongs to the ribosomal proteins S4p/S9e%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2534 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2534 ZOBELLIA_2535 ZOBELLIA_2535 rpoA rpoA 2988700 2989692 + DNA-dependent RNA polymerase%2C alpha subunit The alpha subunit of RNA polymerase initiates the polymerase core assembly by dimerising to form a platform on which the catalytic beta and beta' and omega subunits can interact with DNA%3B The N-terminal domain is essential for RNA polymerase assembly and basal transcription of DNA into RNA%2C whereas the C-terminal domain is necessary for transcription regulation%2C interacting with transcription factors and promoter upstream elements%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2535 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2535 ZOBELLIA_2536 ZOBELLIA_2536 rplQ rplQ 2989754 2990320 + Ribosomal protein L17 Ribosomal protein L17 is one of the proteins from the 50S ribosomal subunit%3B Belongs to a ribosomal proteins L17b/YmL8 (yeast) family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2536 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2536 ZOBELLIA_2537 ZOBELLIA_2537 carA carA 2990414 2991541 + Carbamoyl-phosphate synthase small chain Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. It is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia%2C which is used by the large chain to synthesize carbamoyl phosphate. Binds three magnesium ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2537 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2537 ZOBELLIA_2538 ZOBELLIA_2538 enoA enoA 2991655 2992947 + Enolase Enolase (2-phospho-D-glycerate hydrolase) catalyzes the dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate in the ninth and penultimate step of the glycolysis (Embden-Meyerhof pathway). Enolase can also catalyze the reverse reaction%2C depending on environmental concentrations of substrates. It is a dimeric enzyme that requires magnesium both for catalysis and stabilizing the dimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2538 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2538 ZOBELLIA_2539 ZOBELLIA_2539 glgA glgA 2993081 2994616 + Bacterial glycogen synthase%2C family GT5 Bacterial glycogen synthase synthesizes alpha-1%2C4-glucan chains found in bacterial glycogen using ADP-glucose. Belongs to the family 5 of glycosyltransferases (GT5). Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2539 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2539 ZOBELLIA_254 ZOBELLIA_254 ZOBELLIA_254 323472 325748 + Hypothetical periplasmic protein Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene254 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_254 ZOBELLIA_2540 ZOBELLIA_2540 gltA gltA 2994763 2996049 + Citrate synthase The citrate synthase is the enzyme that catalyzes an important reaction in both energy generation and carbon assimilation%2C the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation%2C that is the first reaction of the tricarboxylic acid cycle (Krebs' cycle). It can directly form a carbon-carbon bond in the absence of metal ion cofactors%3B Allosterically inhibited by NADH%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2540 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2540 ZOBELLIA_2541 ZOBELLIA_2541 ZOBELLIA_2541 2996160 2997074 + DdaH family protein Protein that consists of an amidinotransferase domain%3B Belongs to the Dimethylarginine dimethylaminohydrolase (DdaH) family%3B Localized in the cytoplasm%3B~Family membership gene gene2541 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2541 ZOBELLIA_2542 ZOBELLIA_2542 ZOBELLIA_2542 2997199 2998131 + Conserved hypothetical protein Uncharacterized protein conserved in bacteria containing a pentein-type domain of function unknown%3B Localized in the cytoplasm gene gene2542 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2542 ZOBELLIA_2543 ZOBELLIA_2543 ZOBELLIA_2543 2998140 2999393 - Conserved membrane lipoprotein Outer membrane transport protein from the OmpP1/FadL/TodX family%3B Signal peptide of lipoprotein cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2543 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2543 ZOBELLIA_2544 ZOBELLIA_2544 ZOBELLIA_2544 2999386 3000699 - Conserved membrane lipoprotein Signal peptide of lipoprotein cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2544 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2544 ZOBELLIA_2545 ZOBELLIA_2545 ZOBELLIA_2545 3000940 3001938 + Conserved membrane lipoprotein Lipoprotein that cosists of five repeats of the Kelch domain found in several eukariotic proteins%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2545 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2545 ZOBELLIA_2546 ZOBELLIA_2546 ZOBELLIA_2546 3002004 3002330 + Conserved hypothetical protein Contains a signal peptide cleaved between the residues 21 and 22%3B Probably localized in the periplasmic space gene gene2546 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2546 ZOBELLIA_2547 ZOBELLIA_2547 ZOBELLIA_2547 3002343 3003383 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains four N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2547 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2547 ZOBELLIA_2548 ZOBELLIA_2548 ZOBELLIA_2548 3003386 3004120 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene2548 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2548 ZOBELLIA_2549 ZOBELLIA_2549 ZOBELLIA_2549 3004258 3005013 - Hypothetical protein Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane gene gene2549 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2549 ZOBELLIA_255 ZOBELLIA_255 kduI2 kduI2 325889 326722 + 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase is involved in pectin degradation by pectinolytic microorganisms%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_255 ZOBELLIA_2550 ZOBELLIA_2550 ZOBELLIA_2550 3005010 3005690 - Conserved membrane lipoprotein Lipoprotein that consists of a SCO1/SenC domain%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene2550 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2550 ZOBELLIA_2551 ZOBELLIA_2551 ZOBELLIA_2551 3005659 3006276 - Conserved hypotheical membrane protein Protein that contains five repeats of twenty aminoacids The MORN (membrane occupation and recognition nexus) repeats would contribute to the cytoplasmic membrane binding%2C possibly by interacting with phospholipids%3B Putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene2551 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2551 ZOBELLIA_2552 ZOBELLIA_2552 ZOBELLIA_2552 3006282 3007052 - Conserved membrane lipoprotein Lipoprotein with a signal peptide cleaved between the residues 25 and 26%3B Localized in the outer memebrane%3B~Conserved hypothetical protein gene gene2552 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2552 ZOBELLIA_2553 ZOBELLIA_2553 ZOBELLIA_2553 3007193 3007822 - Hypothetical membrane protein Contains a C-terminal transmembrane segments%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2553 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2553 ZOBELLIA_2554 ZOBELLIA_2554 ZOBELLIA_2554 3007854 3008894 - Conserved membrane lipoprotein Lipoprotein with a signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2554 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2554 ZOBELLIA_2555 ZOBELLIA_2555 ZOBELLIA_2555 3008927 3009205 - Putative exported protein Protein that binds calcium ions%3B Contains two EF-hand domains responsible of the cooperative binding of calcium ions%3B Signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene2555 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2555 ZOBELLIA_2556 ZOBELLIA_2556 ZOBELLIA_2556 3009398 3010429 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains four N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2556 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2556 ZOBELLIA_2557 ZOBELLIA_2557 ZOBELLIA_2557 3010416 3011111 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Hypothetical protein gene gene2557 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2557 ZOBELLIA_2558 ZOBELLIA_2558 ZOBELLIA_2558 3011244 3011399 - Putative protein Hypothetical protein gene gene2558 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2558 ZOBELLIA_2559 ZOBELLIA_2559 opuD opuD 3011736 3013226 - Glycine betaine transporter Permease energized by proton symporter%2C responsible of the high-affinity uptake of the osmoprotectant glycine betaine. Also transports dimethylsulfonioacetate and dimethylsulfoniopropionate%3B Contains twelve transmembrane segments%3B Belongs to the BCCT transporter (for Betaine / Carnitine / Choline Transporters)%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2559 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2559 ZOBELLIA_256 ZOBELLIA_256 ZOBELLIA_256 326738 327940 + Glycoside hydrolase%2C family GH105 This protein belongs to the family 105 of the glycoside hydrolases. These enzymes are involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. Asp183 is the putative catalytic residue (identical to Asp143 of the unsaturated rhamnogalacturonyl hydrolase from Bacillus subtilis%2C Itoh et al.%2C 2006%2C BBRC 347%2C 10211029).%3B~Specificity unclear gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_256 ZOBELLIA_2560 ZOBELLIA_2560 ZOBELLIA_2560 3013327 3014763 - Nucleotide-sugar epimerases Protein That uses nucleotide-sugar substrates for a variety of chemical reactions using NAD as cofactor%3B Contains a C-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2560 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2560 ZOBELLIA_2561 ZOBELLIA_2561 ZOBELLIA_2561 3014779 3015204 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene2561 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2561 ZOBELLIA_2562 ZOBELLIA_2562 argS argS 3015345 3017129 + Arginyl-tRNA synthetase Arginyl-tRNA synthetase also called Arginine-tRNA ligase is a monomeric enzyme that catalyzes the transfer of arginine to specific tRNA molecule as the first step in protein biosynthesis%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2562 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2562 ZOBELLIA_2563 ZOBELLIA_2563 ZOBELLIA_2563 3017181 3018008 + Conserved hypothetical protein Contains a N-terminal transmembrane segment%3B Belong to the DUF (domain of unkown function) 980 family%3B Localized in the cytoplasmic membrane gene gene2563 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2563 ZOBELLIA_2564 ZOBELLIA_2564 SrrA SrrA 3018015 3019004 - Serine racemase Catalyzes the synthesis of D-serine from L-serine%3B Use the pyridoxal phosphate as cofactor (vitamin B6)%3B Belongs to the serine/threonine dehydratase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2564 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2564 ZOBELLIA_2565 ZOBELLIA_2565 ZOBELLIA_2565 3019054 3021573 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (100-162) and a Plug module (198-300) acting as the channel gate%3B The signal peptide is cleaved between the residue 26 and 27%3B~Family membership gene gene2565 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2565 ZOBELLIA_2566 ZOBELLIA_2566 ZOBELLIA_2566 3021563 3022465 - anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Containe a tranmembrane segmemnt%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene2566 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2566 ZOBELLIA_2567 ZOBELLIA_2567 ZOBELLIA_2567 3022661 3023173 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene2567 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2567 ZOBELLIA_2568 ZOBELLIA_2568 ZOBELLIA_2568 3023283 3024656 + Putative membrane lipoprotein Signal peptide cleaved between the residues 22 and 23%3B lipoprotein localized in the outer membrane%3B~Hypothetical protein gene gene2568 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2568 ZOBELLIA_2569 ZOBELLIA_2569 ffh ffh 3024830 3026167 + Signal recognition particle protein (SRP) The signal recognition particle (SRP) is necessary for efficient export of extra-cytoplasmic proteins. It consists of a 4.5S RNA molecule and the protein ffh. It binds to the signal peptide sequence of the protein when it emerges from the ribosomes%3B The Ffh protein has a two domain structure: the G-domain binds GTP and the M-domain binds the RNA and the signal peptide%3B Belongs to the general secretion pathway (Sec machinery)%3B~High confidence in function and specificity gene gene2569 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2569 ZOBELLIA_257 ZOBELLIA_257 ZOBELLIA_257 328095 330323 - Cytochrome c-containing protein Large conserved protein containing a C-terminal cytochrome c. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes. Contains a putative lipoprotein signal peptide cleaved between the residues 22 and 23%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_257 ZOBELLIA_2570 ZOBELLIA_2570 folD folD 3026235 3027119 + Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase Bifunctional enzyme involved in the One-carbon metabolism%2C tetrahydrofolate pathway%3B FolD catalyzes the oxidation of 5%2C10-methylenetetrahydrofolate to 5%2C10-methenyltetrahydrofolate using the NADP as coenzyme and then the hydrolysis of 5%2C10-methenyltetrahydrofolate to 10-formyltetrahydrofolate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2570 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2570 ZOBELLIA_2571 ZOBELLIA_2571 ZOBELLIA_2571 3027258 3028337 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains an N- terminal PAS/PAC domain involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene2571 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2571 ZOBELLIA_2572 ZOBELLIA_2572 ZOBELLIA_2572 3028647 3029948 + Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2572 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2572 ZOBELLIA_2573 ZOBELLIA_2573 ZOBELLIA_2573 3030184 3030942 + Conserved hypothetical membrane protein Protein consisting of a domain of unknown function DUF1080%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene2573 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2573 ZOBELLIA_2574 ZOBELLIA_2574 ZOBELLIA_2574 3030985 3032316 + NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase that adoptd a Rossmann fold%3B Belongs to the GFO/IDH/MOCA family%3B Contains a twin-arginine translocation signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2574 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2574 ZOBELLIA_2575 ZOBELLIA_2575 ZOBELLIA_2575 3032326 3033189 + Carbohydrate esterase%2C family CE1 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 1 of the carbohydrate esterases (CE1)%3B Signal peptide cleaved between residues 21 and 22%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2575 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2575 ZOBELLIA_2576 ZOBELLIA_2576 ZOBELLIA_2576 3033239 3034210 + Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxidoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene2576 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2576 ZOBELLIA_2577 ZOBELLIA_2577 ZOBELLIA_2577 3034264 3034689 - Glyoxalase/extradiol ring-cleavage dioxygenase family Protein that consists of a glyoxalase domain%3B Belongs to the Glyoxalase/bleomycin resistance protein/dioxygenase superfamily%2C Glyoxalase/extradiol ring-cleavage dioxygenase family%3B Localized in the cytoplasm%3B~Family membership gene gene2577 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2577 ZOBELLIA_2578 ZOBELLIA_2578 ZOBELLIA_2578 3034701 3035540 - Hydrolase Hydrolase of unknown function putatively belonging to the alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene2578 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2578 ZOBELLIA_2579 ZOBELLIA_2579 ZOBELLIA_2579 3035553 3036518 - Conserved hypothetical membrane protein Contains five transmembrane segments%3B Belongs to the DUF (domain of unknown function) 161 family%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2579 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2579 ZOBELLIA_258 ZOBELLIA_258 ZOBELLIA_258 330425 331930 - Kelch repeats protein Contains a N-terminal domain of unknown function and a C-terminal domain displaying three Kelch repeats. The kelch motif forms a beta sheet and several of these sheets associate to form a beta propeller structure%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Family membership gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_258 ZOBELLIA_2580 ZOBELLIA_2580 ZOBELLIA_2580 3036557 3037105 - Conserved hypothetical lipoprotein Signal peptide of lipoprotein cleaved between the residues 16 and 17%3B Putatively localized in the outer membrane%3B~Conserved hypothetical protein gene gene2580 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2580 ZOBELLIA_2581 ZOBELLIA_2581 ZOBELLIA_2581 3037154 3038656 - Possible ATPase Possible ATPase%3B Belongs to the DUF (domain of unknown function) 853 family%3B Localized in the cytoplasm%3B~Family membership gene gene2581 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2581 ZOBELLIA_2582 ZOBELLIA_2582 ZOBELLIA_2582 3038849 3039481 + Organic radical activating enzyme Proteins that generates a radical species by reductive cleavage of S-adenosylmethionine (SAM) through an unusual Fe-S centre%3B The cluster 4Fe-4S is coordinated with 3 cysteines and an exchangeable SAM%3B Contains a radical SAM domain%3B Belongs to the organic radical- activating enzymes family%3B Localized in the cytoplasm%3B~Function unclear gene gene2582 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2582 ZOBELLIA_2583 ZOBELLIA_2583 ZOBELLIA_2583 3039486 3040415 - Conserved hypothetical lipoprotein Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2583 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2583 ZOBELLIA_2584 ZOBELLIA_2584 ZOBELLIA_2584 3040464 3041171 - Methyltransferase Methyltransferases modifies DNA%2C RNA%2C proteins and small molecules for regulatory purposes using the S-adenosyl-L-methionine as coenzyme%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2584 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2584 ZOBELLIA_2585 ZOBELLIA_2585 ZOBELLIA_2585 3041184 3041744 + Conserved hypothetical protein Conserved protein belonging to the UPF0153 family. The proteins of this family contain 8 conserved cysteines that may form a metal binding site. Their function is unknown but might be an Fe-S cluster as part of an oxidoreductase complex%3B Localized in the cytoplasm gene gene2585 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2585 ZOBELLIA_2586 ZOBELLIA_2586 ZOBELLIA_2586 3041768 3042250 + Conserved hypothetical protein Conserved hypothetical protein distantly related to effector binding domains found in some bacterial transcriptional activators but also in DNA gyrase inhibitors%3B Localized in the cytoplasm gene gene2586 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2586 ZOBELLIA_2587 ZOBELLIA_2587 ZOBELLIA_2587 3042292 3043152 + Fatty acid hydroxylase family protein Protein belonging to the Fatty acid hydroxylase family%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene2587 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2587 ZOBELLIA_2588 ZOBELLIA_2588 ZOBELLIA_2588 3044413 3045654 + Conserved hypothetical membrane protein Conserved membrane protein distantly related to LolC%2C an permease involved in the ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Features four transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene2589 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2588 ZOBELLIA_2589 ZOBELLIA_2589 ZOBELLIA_2589 3043153 3044463 - Conserved hypothetical lipoprotein Protein belonging to the DUF1343 family. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene2588 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2589 ZOBELLIA_259 ZOBELLIA_259 ZOBELLIA_259 331917 336980 - Hypothetical periplasmic protein Hypothetical protein featuring a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_259 ZOBELLIA_2590 ZOBELLIA_2590 cysK2 cysK2 3045730 3046710 + Cysteine synthase A The cysteine synthase is the enzyme responsible for the formation of cysteine from O-acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid%3B Uses the pyridoxal phosphate as cofactor (vitamin B6) attached to a conserved lysine residue%3B Belongs to the cysteine synthase/cystathionine beta-synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2590 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2590 ZOBELLIA_2591 ZOBELLIA_2591 ZOBELLIA_2591 3046774 3047553 + Aldose 1-epimerase family protein Enzymes that probably binds carbohydrates and that act on sugars%3B The protein consists to an aldose 1-epimerase domain%3B Its exact function is unknown%3B Localized in the cytoplasm%3B~Family membership gene gene2591 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2591 ZOBELLIA_2592 ZOBELLIA_2592 crpA2 crpA2 3047563 3048195 + Catabolite gene activator This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. It displays a N-terminal cyclic nucleotide-binding domain and a C-terminal helix-turn-helix DNA-binding domain. The cyclic nucleotide-binding domain is composed of three alpha-helices and a distinctive eight-stranded%2C antiparallel beta-barrel structure. There are six invariant amino acids in this domain%2C three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta- barrel. Localized in the cytoplasm.%3B~Specificity unclear gene gene2592 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2592 ZOBELLIA_2593 ZOBELLIA_2593 ZOBELLIA_2593 3048260 3048841 + TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene2593 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2593 ZOBELLIA_2594 ZOBELLIA_2594 ZOBELLIA_2594 3048914 3049774 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene2594 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2594 ZOBELLIA_2595 ZOBELLIA_2595 ccpA2 ccpA2 3049888 3051060 + Di-heme cytochrome c peroxidase Di-heme cytochrome c peroxidase (CCP) reduces hydrogen peroxide to water using c-type heme as an oxidizable substrate. However%2C since it possesses two%2C instead of one%2C heme prosthetic groups%2C CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two heme groups have significantly different redox potentials. CCP is structured into two domains%2C each containing one c-type heme group%2C with a calcium-binding site at the domain interface%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene2595 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2595 ZOBELLIA_2596 ZOBELLIA_2596 ZOBELLIA_2596 3051145 3052875 + Sulfate transporter Sulfate transporter is a H(+)/sulfate cotransporter that may play a role in the regulation of sulfate assimilation%3B Contains eleven N-terminal transmembrane helices and a C-terminal STAS domain (Sulphate Transporter and AntiSigma factor antagonist) probably involved in a general NTP binding function%3B Belongs to the SLC26A/SulP transporter family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2596 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2596 ZOBELLIA_2597 ZOBELLIA_2597 ZOBELLIA_2597 3053008 3054417 + Metallo-beta-lactamase superfamily protein Protein with a N-terminal metallo beta-lactamase domain and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site Cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue%3B binds two zinc ions per molecule as cofactor%3B Localized in the cytoplasm%3B~Function unclear gene gene2597 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2597 ZOBELLIA_2598 ZOBELLIA_2598 ZOBELLIA_2598 3054498 3054947 - Conserved hypothetical protein localized in the cytoplasm gene gene2598 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2598 ZOBELLIA_2599 ZOBELLIA_2599 ZOBELLIA_2599 3055285 3055479 - Putative protein Hypothetical protein gene gene2599 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2599 ZOBELLIA_26 ZOBELLIA_26 rpsR rpsR 26934 27230 - Ribosomal protein S18 The ribosomal protein S18 is a secondary rRNA binding protein of the ribosomal small subunit (30S)%2C known to be involved in binding the aminoacyl-tRNA complex%2C and appears to be situated at the tRNA A-site. It binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%2C where it helps to stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S18p family%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_26 ZOBELLIA_260 ZOBELLIA_260 ZOBELLIA_260 337016 339022 - Hypothetical periplasmic protein Hypothetical protein featuring a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_260 ZOBELLIA_2600 ZOBELLIA_2600 porA porA 3055451 3056983 - Beta-porphyranase A%2C family GH16 The beta-porphyranases hydrolyse the 1%2C4-beta-D-galactosidic linkages in porphyrans%3B Contains a C-terminal domain of unknown function%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2600 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2600 ZOBELLIA_2601 ZOBELLIA_2601 ZOBELLIA_2601 3057461 3058000 - CAZ96751.1 Conserved hypothetical protein belonging to the DUF984 family. Localized in the cytoplasm. gene gene2601 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2601 ZOBELLIA_2602 ZOBELLIA_2602 ZOBELLIA_2602 3058324 3058416 - Putative protein Hypothetical protein gene gene2602 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2602 ZOBELLIA_2603 ZOBELLIA_2603 ZOBELLIA_2603 3058606 3058734 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2603 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2603 ZOBELLIA_2604 ZOBELLIA_2604 ZOBELLIA_2604 3059077 3060462 - Nuclease Contains a N-terminal exonuclease domain found in ribonuclease T and the epsilon subunit of DNA polymerase III and%2C in the middle part%2C a GIY-YIG catalytic domain Localized in the cytoplasm%3B~Function unclear gene gene2604 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2604 ZOBELLIA_2605 ZOBELLIA_2605 ZOBELLIA_2605 3060659 3062176 + Conserved hypothetical protein Conserved hypothetical protein distantly related to the Auxin-responsive GH3-like proteins%3B Localized in the cytoplasm gene gene2605 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2605 ZOBELLIA_2606 ZOBELLIA_2606 ZOBELLIA_2606 3062197 3062775 - Conserved hypothetical protein Localized in the cytoplasm gene gene2606 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2606 ZOBELLIA_2607 ZOBELLIA_2607 ZOBELLIA_2607 3062992 3064572 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2607 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2607 ZOBELLIA_2608 ZOBELLIA_2608 ZOBELLIA_2608 3064642 3065052 + Conserved hypothetical protein Localized in the cytoplasm gene gene2608 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2608 ZOBELLIA_2609 ZOBELLIA_2609 ZOBELLIA_2609 3065155 3065340 + CsbD-like protein CsbD is a bacterial general stress response protein. Its expression is mediated by sigma-B%2C an alternative sigma factor. The role of CsbD in stress response is unclear. Localized in the cytoplasm.%3B~Function unclear gene gene2609 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2609 ZOBELLIA_261 ZOBELLIA_261 ZOBELLIA_261 339153 341732 - Hypothetical membrane protein Hypothetical protein containing an uncleaved signal peptide. Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_261 ZOBELLIA_2610 ZOBELLIA_2610 ZOBELLIA_2610 3065399 3065719 - Conserved hypothetical protein Localized in the cytoplasm gene gene2610 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2610 ZOBELLIA_2611 ZOBELLIA_2611 ZOBELLIA_2611 3065802 3065963 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF1328 family. Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2611 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2611 ZOBELLIA_2612 ZOBELLIA_2612 ZOBELLIA_2612 3066129 3067397 - Manganese/fer transporter Protein that Belongs to the NRAMP family (resistance-associated macrophage protein)%3B This family of membrane proteins are divalent cation transporters%3B Contains 10 transmembrane segments%3B Possible peptide signal cleaved between the residues 25 and 26%3B localized in the cytoplasmic membrane%3B~Family membership gene gene2612 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2612 ZOBELLIA_2613 ZOBELLIA_2613 pfp pfp 3067454 3068680 - Diphosphate-fructose-6-phosphate 1-phosphotransferase Diphosphate-fructose-6-phosphate 1-phosphotransferase catalyzes the reversible phosphorylation of fructose-6-phosphate using pyrophoshate instead of ATP for phosphofructokinase (Pfk). Involved in glycolysis. It forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2613 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2613 ZOBELLIA_2614 ZOBELLIA_2614 kdgK1 kdgK1 3068699 3069739 - 2-dehydro-3-deoxygluconokinase The 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP) in the Entner-Doudoroff pathway. KDG is the common intermediate product%2C that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers%2C like pectin and xylan as carbon sources%3B Belongs to the Carbohydrate kinase%2C PfkB family%2C 2-dehydro-3-deoxygluconokinase (KdgK) subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2614 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2614 ZOBELLIA_2615 ZOBELLIA_2615 ZOBELLIA_2615 3069794 3070549 - Acetoin(diacetyl) reductase The enzymes of this family are very similar and display high sequence identities%2C the substrate specificity is difficult to determine%3B A match to Glucose/ribitol dehydrogenase subfamily indicates that the protein is not an alcohol dehydrogenase%2C but another type of dehydrogenase or reductase%3B Possible signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the periplasmic space%3B~Family membership gene gene2615 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2615 ZOBELLIA_2616 ZOBELLIA_2616 ZOBELLIA_2616 3070586 3071863 - Sugar permease The Sugar permeases belong to the major facilitator superfamily (MFS) transporters that are single-polypeptide secondary carriers capable only of transporting small solutes (probably sugars in this case) in response to chemiosmotic ion gradients%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2616 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2616 ZOBELLIA_2617 ZOBELLIA_2617 ZOBELLIA_2617 3072094 3072822 - GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B Contains an N-terminal HTH domain of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA and a C-terminal FCD domain that probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N- terminal DNA-binding domain (HTH domain)%3B Localized in the cytoplasm%3B~Family membership gene gene2617 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2617 ZOBELLIA_2618 ZOBELLIA_2618 alyA2 alyA2 3073064 3073987 - Alginate lyase%2C family PL7 Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. It belongs to the family 7 of the polysaccharide lyases. Features a signal peptide cleaved between residues 32 and 33. Localized in the periplasm.%3B~High confidence in function and specificity gene gene2618 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2618 ZOBELLIA_2619 ZOBELLIA_2619 ZOBELLIA_2619 3073996 3074877 - Conserved hypothetical lipoprotein Contains a N-terminal PKD domain present in the extracellular parts of proteins involved in interactions with other protein or polysaccharides and a C-terminal putative carbohydrate binding module (CBM)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 28 and 29%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2619 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2619 ZOBELLIA_262 ZOBELLIA_262 ZOBELLIA_262 341775 341924 - Putative protein Hypothetical protein gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_262 ZOBELLIA_2620 ZOBELLIA_2620 ZOBELLIA_2620 3074908 3076338 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B~Family membership gene gene2620 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2620 ZOBELLIA_2621 ZOBELLIA_2621 ZOBELLIA_2621 3076372 3079497 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (26-98) and the Plug module (115-224) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene2621 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2621 ZOBELLIA_2622 ZOBELLIA_2622 ZOBELLIA_2622 3079956 3080708 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene2622 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2622 ZOBELLIA_2623 ZOBELLIA_2623 kdgF kdgF 3080714 3081064 - Pectin degradation protein KdgF KdgF is involved in pectin degradation%2C but its exact function is still unknown. It adopts a Cupin beta barrel fold. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2623 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2623 ZOBELLIA_2624 ZOBELLIA_2624 alyA3 alyA3 3081074 3083329 - Alginate lyase%2C family PL17 Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. It belongs to the family 17 of the polysaccharide lyases. Features an uncleaved signal peptide. Features a signal peptide cleaved between residues 25 and 26. Localized in the periplasm.%3B~High confidence in function and specificity gene gene2624 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2624 ZOBELLIA_2625 ZOBELLIA_2625 ZOBELLIA_2625 3083628 3083732 - Putative protein Hypothetical protein gene gene2625 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2625 ZOBELLIA_2626 ZOBELLIA_2626 ZOBELLIA_2626 3083843 3084811 + Xylose isomerase-like TIM barrel protein This protein adopts a Xylose isomerase-like TIM barrel fold%3B Localized in the cytoplasm%3B~Function unclear gene gene2626 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2626 ZOBELLIA_2627 ZOBELLIA_2627 ZOBELLIA_2627 3084834 3085562 + Conserved hypothetical protein Contains a Dimethylmenaquinone methyltransferase domain%3B Localized in the cytoplasm gene gene2627 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2627 ZOBELLIA_2628 ZOBELLIA_2628 ZOBELLIA_2628 3085570 3086379 - Conserved hypothetical protein Localized in the cytoplasm gene gene2628 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2628 ZOBELLIA_2629 ZOBELLIA_2629 ZOBELLIA_2629 3086381 3086824 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2629 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2629 ZOBELLIA_263 ZOBELLIA_263 afcA1 afcA1 341985 344318 - Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Features a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic or/and outer membrane%3B~High confidence in function and specificity gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_263 ZOBELLIA_2630 ZOBELLIA_2630 ZOBELLIA_2630 3086901 3088187 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain. Contains two transmembrane segments. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene2630 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2630 ZOBELLIA_2631 ZOBELLIA_2631 ZOBELLIA_2631 3088184 3088861 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity (here%2C a winged-helix DNA-binding domain) that acts as transcriptional regulator%3B~Family membership gene gene2631 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2631 ZOBELLIA_2632 ZOBELLIA_2632 ZOBELLIA_2632 3088962 3090641 - Amidohydrolase This protein would catalyse the hydrolysis of amide or amine bonds in various substrates. It adopts a classical alpha-beta TIM-barrel fold. The active site is located in the mouth of the enzyme barrel and contains a bound iron ion that coordinates a hydroxyl nucleophile%3B Belongs to the Amidohydrolase family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Specificity unclear gene gene2632 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2632 ZOBELLIA_2633 ZOBELLIA_2633 ZOBELLIA_2633 3090666 3092285 - Metallopeptidase%2C family M28 Family M28 contains aminopeptidases and carboxypeptidases with two co-catalytic zinc ions (I and II). Each zinc ion is tetrahedrally co-ordinated%2C with three amino acid ligands plus activated water%3B one aspartate residue binds both metal ions. The zinc ligands occur in the sequence in the order His (II)%2C Asp (I and II)%2C Glu (I)%2C Asp or Glu (II) and His (I). In addition%2C two other residues%2C an Asp and a Glu%2C are believed to be important for catalysis. Four of these residues occur in the motifs His-Xaa-Asp and Glu-Glu. Localized in the cytoplasm%3B~Specificity unclear gene gene2633 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2633 ZOBELLIA_2634 ZOBELLIA_2634 ZOBELLIA_2634 3092740 3093681 + Conserved hypothetical protein Localized in the cytoplasm gene gene2634 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2634 ZOBELLIA_2635 ZOBELLIA_2635 ZOBELLIA_2635 3093693 3094046 + Hypothetical protein Localized cin the cytoplasm gene gene2635 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2635 ZOBELLIA_2636 ZOBELLIA_2636 ZOBELLIA_2636 3094722 3094979 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2637 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2636 ZOBELLIA_2637 ZOBELLIA_2637 gntK1 gntK1 3094235 3094735 - Gluconokinase Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate%3B GntK adopts an alpha/beta fold%2C consisting of a central sheet of five parallel beta-strands flanked by alpha-helices%3B Belongs to the shikimate kinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2636 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2637 ZOBELLIA_2638 ZOBELLIA_2638 iolC iolC 3094990 3095991 + 5-dehydro-2-deoxygluconokinase The 5-dehydro-2-deoxygluconokinase catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP)%3B Belongs to the carbohydrate kinase PfkB family%2C 2-dehydro-3-deoxygluconokinase (KdgK) subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2638 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2638 ZOBELLIA_2639 ZOBELLIA_2639 ZOBELLIA_2639 3096041 3096721 - Possible dioxygenase Possible dioxygenase involved in the cleavage of aromatic rings%3B Contains an N-terminal glyoxalase I domain%3B Belongs to the Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene2639 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2639 ZOBELLIA_264 ZOBELLIA_264 ZOBELLIA_264 344405 344539 + Putative protein Hypothetical protein gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_264 ZOBELLIA_2640 ZOBELLIA_2640 ZOBELLIA_2640 3096749 3096847 + Putative protein Hypothetical protein gene gene2640 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2640 ZOBELLIA_2641 ZOBELLIA_2641 ZOBELLIA_2641 3096970 3097719 - Conserved hypothetical protein Seems to contain a Carboxypeptidase-like%2C regulatory domain%3B Localized in the cytoplasm gene gene2641 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2641 ZOBELLIA_2642 ZOBELLIA_2642 ZOBELLIA_2642 3097921 3098220 - conserved hypothetical membrane protein Contains an N- and C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2642 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2642 ZOBELLIA_2643 ZOBELLIA_2643 ZOBELLIA_2643 3098223 3098723 - Conserved hypothetical membrane protein Contains four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2643 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2643 ZOBELLIA_2644 ZOBELLIA_2644 ZOBELLIA_2644 3098720 3100363 - Conserved hypothetical membrane protein Contains three central transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2644 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2644 ZOBELLIA_2645 ZOBELLIA_2645 ZOBELLIA_2645 3100356 3101282 - Hypothetical membrane protein Contains three N-terminal and one C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2645 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2645 ZOBELLIA_2646 ZOBELLIA_2646 ZOBELLIA_2646 3101298 3102521 - Conserved hypothetical membrane protein Contains two N-terminal transmembranse segments and a C-terminal transmembranse segment%3B Localized in the membrane cytoplasmic%3B~Conserved hypothetical protein gene gene2646 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2646 ZOBELLIA_2647 ZOBELLIA_2647 ZOBELLIA_2647 3102526 3103068 - Hypothetical protein Localized in the cytoplasm gene gene2647 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2647 ZOBELLIA_2648 ZOBELLIA_2648 ZOBELLIA_2648 3103739 3104206 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2648 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2648 ZOBELLIA_2649 ZOBELLIA_2649 ZOBELLIA_2649 3104554 3104817 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2649 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2649 ZOBELLIA_265 ZOBELLIA_265 ZOBELLIA_265 344523 344627 + Putative protein Hypothetical protein gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_265 ZOBELLIA_2650 ZOBELLIA_2650 ZOBELLIA_2650 3105100 3105738 - TonB-like protein TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Energy flows from the cytoplasmic membrane into the outer membrane via a complex consisting of TonB%2C ExbB and ExbD proteins which are anchored in the cytoplasmic membrane. TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates%3B Although belonging to the TonB family%2C this protein seems to contain a signal peptide cleaved between the residues 17 and 18%2C which is unsual for classical TonB proteins%3B Putatively localized in the periplasmic space%3B~Specificity unclear gene gene2650 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2650 ZOBELLIA_2651 ZOBELLIA_2651 ZOBELLIA_2651 3105946 3106776 - Conserved hypothetical membrane protein Contains two transmembrane helices in the N-terminal region. The C-terminal region is highly Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2651 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2651 ZOBELLIA_2652 ZOBELLIA_2652 ZOBELLIA_2652 3107110 3107310 - Putative protein Hypothetical protein gene gene2652 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2652 ZOBELLIA_2653 ZOBELLIA_2653 ZOBELLIA_2653 3107270 3107368 - Putative protein Hypothetical protein gene gene2653 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2653 ZOBELLIA_2654 ZOBELLIA_2654 ZOBELLIA_2654 3107938 3108234 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2654 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2654 ZOBELLIA_2655 ZOBELLIA_2655 ZOBELLIA_2655 3108215 3110227 - Conserved hypothetical protein Contains an N-terminal PHP (Polymerase and Histidinol Phosphatase) domain which is a putative phosphoesterase domain and a putative C-terminal ABC (ATP-binding cassette) transporter%2C ABC ATPase domain%3B Could belong to the PHP superfamily%3B Localized in the cytoplasm gene gene2655 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2655 ZOBELLIA_2656 ZOBELLIA_2656 ZOBELLIA_2656 3110540 3111505 - Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene2656 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2656 ZOBELLIA_2657 ZOBELLIA_2657 ZOBELLIA_2657 3111679 3111927 + Conserved hypothetical protein Localized in the cytoplasm. gene gene2657 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2657 ZOBELLIA_2658 ZOBELLIA_2658 ZOBELLIA_2658 3112103 3112234 + Putative protein Hypothetical protein gene gene2658 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2658 ZOBELLIA_2659 ZOBELLIA_2659 PhoD2 PhoD2 3112259 3113671 - Probable alkaline phosphatase Alkaline phosphatase is a zinc and magnesium-containing metalloenzyme which hydrolyzes phosphate esters%2C optimally at high pH%3B Alkaline phosphatase exists as a dimer%2C each monomer binding 2 zinc atoms and one magnesium atom%2C which are essential for enzymic activity%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2659 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2659 ZOBELLIA_266 ZOBELLIA_266 ZOBELLIA_266 344850 346526 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Probably localized in the outer membrane%3B~Family membership gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_266 ZOBELLIA_2660 ZOBELLIA_2660 wrbA wrbA 3113771 3114346 - NAD(P)H dehydrogenase [quinone] The enzyme catalyse the NAD(P)H-dependent two-electron reductions of quinones%3B It apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons to protect cells against damage by free radicals and reactive oxygen species%3B It has a preference for short-chain acceptor quinones%2C such as ubiquinone%2C benzoquinone%2C juglone and duroquinone%3B Uses a FAD cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2660 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2660 ZOBELLIA_2661 ZOBELLIA_2661 ZOBELLIA_2661 3114421 3115233 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene2661 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2661 ZOBELLIA_2662 ZOBELLIA_2662 ZOBELLIA_2662 3115247 3115630 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2662 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2662 ZOBELLIA_2663 ZOBELLIA_2663 ZOBELLIA_2663 3116775 3119744 + CBM6 containing protein Conserved protein featuring a N-terminal conserved domain of unknown function%2C a central PKD domain and a C-terminal carbohydrate binding module of the family 6. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm.%3B~Conserved hypothetical protein gene gene2663 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2663 ZOBELLIA_2664 ZOBELLIA_2664 ZOBELLIA_2664 3119897 3121840 + Beta-helix fold protein This protein likely adopts a right handed parallel beta-helix fold. Displays also a C-terminal PKD domain%3B Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Function unclear gene gene2664 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2664 ZOBELLIA_2665 ZOBELLIA_2665 ZOBELLIA_2665 3121912 3124650 + Beta-helix fold protein containing CBM13 Modular protein containing a N-terminal domain adopting a parallel beta-helix fold and a C-terminal carbohydrate binding module of the family 13 (CBM13). The N-terminal domain is distantly related to the polysaccharide lyases of the family 9 (PL9). Features a signal peptide cleaved between residues 26 and 27. Localized in the periplasm.%3B~Specificity unclear gene gene2665 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2665 ZOBELLIA_2666 ZOBELLIA_2666 ZOBELLIA_2666 3124770 3124979 - Conserved hypothetical protein Possibly localized in the cytoplasm gene gene2666 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2666 ZOBELLIA_2667 ZOBELLIA_2667 ZOBELLIA_2667 3125073 3125306 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene2667 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2667 ZOBELLIA_2668 ZOBELLIA_2668 ZOBELLIA_2668 3125378 3125836 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2668 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2668 ZOBELLIA_2669 ZOBELLIA_2669 ZOBELLIA_2669 3125905 3126495 - TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene2669 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2669 ZOBELLIA_267 ZOBELLIA_267 ZOBELLIA_267 346544 349666 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (31-104) and the Plug module (120-218) acting as a channel gate. The signal peptide is cleaved between the residues 29 and 30.%3B~Family membership gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_267 ZOBELLIA_2670 ZOBELLIA_2670 ZOBELLIA_2670 3126618 3126734 + Putative protein Hypothetical protein gene gene2670 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2670 ZOBELLIA_2671 ZOBELLIA_2671 ZOBELLIA_2671 3126872 3128035 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene2671 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2671 ZOBELLIA_2672 ZOBELLIA_2672 ZOBELLIA_2672 3128278 3131355 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly sugars) that are too large to diffuse via the outer membrane porins or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-96)%2C the Plug module (112-227) acting as the channel gate and a pectinesterase signature (404-423)%3B The signal peptide is cleaved between the residue 25 and 26%3B~Family membership gene gene2672 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2672 ZOBELLIA_2673 ZOBELLIA_2673 ZOBELLIA_2673 3131367 3132836 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B~Family membership gene gene2673 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2673 ZOBELLIA_2674 ZOBELLIA_2674 ZOBELLIA_2674 3132934 3134316 + hypothetical membrane protein Signal peptide cleaved between the residues 23 and 24%3B Putatively localized in the outer membrane%3B~Hypothetical protein gene gene2674 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2674 ZOBELLIA_2675 ZOBELLIA_2675 ZOBELLIA_2675 3134541 3135503 + Sugar kinase Enzymes that catalyze the transfer of phosphoryl group on a sugar from ATP%2C producing a phosphorylated sugar%3B Belongs to the ROK family%3B localized in the cytoplasm%3B~Specificity unclear gene gene2675 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2675 ZOBELLIA_2676 ZOBELLIA_2676 ZOBELLIA_2676 3135490 3136977 + Sugars permease The Sugars permeases belong to the major facilitator superfamily (MFS) transporters that are single- polypeptide secondary carriers capable only of transporting small solutes (probably sugars in this case) in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2676 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2676 ZOBELLIA_2677 ZOBELLIA_2677 ZOBELLIA_2677 3136964 3138721 + Sugar-phosphate isomerase Sugar-phosphate isomerases are the enzyme that converts a sugar-phosphate to another sugar-phosphate. It consists of an N-terminal domain of unkown function and a C-terminal putative phosphomannose isomerase type I domain%3B Binds 1 zinc ion per subunit%3B Belongs to the the cupin superfamily%2C mannose-6-phosphate isomerase type 1 family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2677 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2677 ZOBELLIA_2678 ZOBELLIA_2678 ZOBELLIA_2678 3138721 3139503 + Sugar-phosphate isomerase Sugar-phosphate isomerases catalyse the conversion of sugar-phosphate to another sugar-phosphate%3B Contains a Glucose-6-phosphate isomerase domain%3B Binds 1 iron ion per subunit%3B Belongs to the cupin superfamily%2C archaeal-type GPI family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2678 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2678 ZOBELLIA_2679 ZOBELLIA_2679 ZOBELLIA_2679 3139560 3140960 + Sulfatase%2C family S1-14 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 14%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Family membership gene gene2679 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2679 ZOBELLIA_268 ZOBELLIA_268 ZOBELLIA_268 349767 349910 + Putative protein Hypothetical protein gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_268 ZOBELLIA_2680 ZOBELLIA_2680 ZOBELLIA_2680 3141018 3141434 + Conserved hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2680 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2680 ZOBELLIA_2681 ZOBELLIA_2681 ZOBELLIA_2681 3141542 3143857 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-89) and the Plug module (110-221) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene2681 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2681 ZOBELLIA_2682 ZOBELLIA_2682 ZOBELLIA_2682 3143914 3145170 + Conserved hypothetical membrane protein Contains five PepSY-associated transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2682 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2682 ZOBELLIA_2683 ZOBELLIA_2683 ZOBELLIA_2683 3145370 3145483 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2683 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2683 ZOBELLIA_2684 ZOBELLIA_2684 ZOBELLIA_2684 3145994 3146740 + Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2684 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2684 ZOBELLIA_2685 ZOBELLIA_2685 ZOBELLIA_2685 3146748 3147260 + Conserved hypothetical protein Belongs to the LemA family%3B Localized in the cytoplasm gene gene2685 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2685 ZOBELLIA_2686 ZOBELLIA_2686 ZOBELLIA_2686 3147265 3148461 + Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2686 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2686 ZOBELLIA_2687 ZOBELLIA_2687 ZOBELLIA_2687 3148764 3148952 + Putative protein Hypothetical protein gene gene2687 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2687 ZOBELLIA_2688 ZOBELLIA_2688 ZOBELLIA_2688 3149074 3149166 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2688 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2688 ZOBELLIA_2689 ZOBELLIA_2689 ZOBELLIA_2689 3149444 3149773 + Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2689 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2689 ZOBELLIA_269 ZOBELLIA_269 ZOBELLIA_269 350262 354335 + One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_269 ZOBELLIA_2690 ZOBELLIA_2690 ZOBELLIA_2690 3149856 3150560 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2690 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2690 ZOBELLIA_2691 ZOBELLIA_2691 ZOBELLIA_2691 3150572 3153241 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (29-112) and the Plug module (acting as a channel gate%3B The signal peptide is cleaved between the residues 25 and 26%3B~Family membership gene gene2691 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2691 ZOBELLIA_2692 ZOBELLIA_2692 ZOBELLIA_2692 3153589 3154824 + Tn4399-type Integrase Integrases are tyrosine recombinases that act by catalyzing the cutting and rejoining of the recombining DNA molecules utilizing a catalytic tyrosine for the strand cleavage. The cleavage of DNA is realized by a series of staggered cuts%2C during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue%3B Contains a C-terminal Phage integrase domain%3B Belongs to the \\phage\\ integrase family%2C Tn4399-type Integrase subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene2692 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2692 ZOBELLIA_2693 ZOBELLIA_2693 ZOBELLIA_2693 3155147 3156643 + Conserved hypothetical protein Localized in the cytoplasm. gene gene2693 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2693 ZOBELLIA_2694 ZOBELLIA_2694 ZOBELLIA_2694 3156998 3157114 - Putative protein Hypothetical protein gene gene2694 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2694 ZOBELLIA_2695 ZOBELLIA_2695 ZOBELLIA_2695 3157299 3159044 - Hypothetical membrane protein Contains a C-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2695 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2695 ZOBELLIA_2696 ZOBELLIA_2696 hsdS1 hsdS1 3159046 3160452 - Type I restriction enzyme ZgaDI%2C S subunit The Type I restriction enzyme S subunit dictates DNA sequences specificity%3B Contains two DNA recognition domains%2C each specifying recognition of one of the two defined components of the bipartite DNA target sequence%3B The type I restriction enzyme%2C M and S subunits together form a N-6 adenine methyltransferase (MTase) that methylates the amino group at the C-6 position of a adenine residue in a hemimethylated DNA recognition sequence%2C in order to prevent the host from digesting its own genome via its restriction enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2696 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2696 ZOBELLIA_2697 ZOBELLIA_2697 hsdM1 hsdM1 3160449 3161912 - Type I restriction enzyme ZgaDI%2C M subunit The type I restriction enzyme%2C M and S subunits together form a N-6 adenine methyltransferase (MTase) that methylates the amino group at the C-6 position of a adenine residue in a hemimethylated bipartite DNA recognition sequence%2C in order to prevent the host from digesting its own genome via its restriction enzyme. It acts as a maintenance MTase modifying the DNA so that both strands become methylated. If the recognition sequence is unmethylated%2C in the presence of the R subunit%2C the complex can also act as an endonuclease%2C binding to the same target sequence but cutting the DNA some distance from this site%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2697 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2697 ZOBELLIA_2698 ZOBELLIA_2698 hsdR1 hsdR1 3161935 3165150 - Type I restriction enzyme ZgaDI%2C R subunit The type I restriction enzyme%2C Subunit R recognize specific short DNA sequences and cleaves at sites remote (1000 to 5000 bp) from the recognition sequence to give random double-stranded fragments with terminal 5'-phosphates. It is required for both endonuclease and ATPase activities%2C but not for modification%3B The Type I restriction and modification enzymes are complex%2C multifunctional systems composed of three polypeptides R%2C M and S and which require ATP%2C S-adenosyl methionine and magnesium as cofactors. In addition to their endonucleolytic and methylase activities%2C they are potent DNA-dependent ATPases%3B The sequence recognized by ZgaDI is unknown%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2698 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2698 ZOBELLIA_2699 ZOBELLIA_2699 ZOBELLIA_2699 3165461 3165694 + Conserved hypothetical protein Conserved hypothetical protein belonging to the UPF0156 family. Localized in the cytoplasm.%3B~Family membership gene gene2699 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2699 ZOBELLIA_27 ZOBELLIA_27 rpsF rpsF 27237 27575 - Ribosomal protein S6 The ribosomal protein S6 is a part of the ribosomal small subunit (30S). It binds as a heterodimer with protein S18 to the central domain of the 16S rRNA%2C where it helps to stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S6p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_27 ZOBELLIA_270 ZOBELLIA_270 bcpA bcpA 354389 354964 - Peroxiredoxin Peroxiredoxin is a thioredoxin-dependent thiol peroxidase. BCP preferentially reduced linoleic acid hydroperoxide rather than H2O2 and t-butyl hydroperoxide with the use of thioredoxin as an in vivo immediate electron donor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_270 ZOBELLIA_2700 ZOBELLIA_2700 ZOBELLIA_2700 3166004 3166273 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2700 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2700 ZOBELLIA_2701 ZOBELLIA_2701 ZOBELLIA_2701 3166347 3167069 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF159 family. Localized in the cytoplasm. gene gene2701 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2701 ZOBELLIA_2702 ZOBELLIA_2702 ZOBELLIA_2702 3167276 3168211 - Hypothetical protein Localized in the cytoplasm gene gene2702 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2702 ZOBELLIA_2703 ZOBELLIA_2703 ZOBELLIA_2703 3168451 3168684 - Ribbon-helix-helix fold protein Conserved protein adopting a a ribbon-helix-helix core topology consisting of four helices in an open array of two hairpins. Such domains are found in several bacterial and phage repressors. Localized in the cytoplasm.%3B~Family membership gene gene2703 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2703 ZOBELLIA_2704 ZOBELLIA_2704 traA traA 3168735 3169319 - Conjugative transposon protein TraA TraA is part of a conjugative transposon and is predicted to be involved in its transfer. Belongs to the CobQ/CobB/MinD/ParA nucleotide binding protein family. Localized in the cytoplasm.%3B~Function unclear gene gene2704 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2704 ZOBELLIA_2705 ZOBELLIA_2705 ZOBELLIA_2705 3169322 3169771 - Hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2705 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2705 ZOBELLIA_2706 ZOBELLIA_2706 mobB mobB 3169774 3170625 - Mobilization protein MobB Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation%3B Localized in the cytoplasm%3B~Family membership gene gene2706 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2706 ZOBELLIA_2707 ZOBELLIA_2707 ZOBELLIA_2707 3170622 3171014 - Conserved hypothetical protein Localized in the cytoplasm gene gene2707 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2707 ZOBELLIA_2708 ZOBELLIA_2708 traP traP 3171019 3171852 - Conjugative transposon proteinTraP TraP is part of a conjugative transposon ans is predicted as a transfer primase. Contains an N-terminal CHC2 (CycHisCysCys type) zinc finger domain suggesting that this protein binds to substrates as DNA%2C RNA. Localized in the cytoplasm.%3B~Function unclear gene gene2708 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2708 ZOBELLIA_2709 ZOBELLIA_2709 ZOBELLIA_2709 3171921 3172253 - Hypothetical protein Localized in the cytoplasm gene gene2709 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2709 ZOBELLIA_271 ZOBELLIA_271 ZOBELLIA_271 355533 358625 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (30-103) and the Plug module (119-242) acting as a channel gate%3B The signal peptide is cleaved between the residues 28 and 29%3B~Family membership gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_271 ZOBELLIA_2710 ZOBELLIA_2710 ZOBELLIA_2710 3172250 3173341 - Hypothetical protein Localized in the cytoplasm gene gene2710 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2710 ZOBELLIA_2711 ZOBELLIA_2711 ZOBELLIA_2711 3173425 3173715 - Hypothetical protein Localized in the cytoplasm gene gene2711 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2711 ZOBELLIA_2712 ZOBELLIA_2712 ZOBELLIA_2712 3173789 3174661 - Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2712 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2712 ZOBELLIA_2713 ZOBELLIA_2713 ZOBELLIA_2713 3175358 3175510 - Putative protein Hypothetical protein gene gene2713 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2713 ZOBELLIA_2714 ZOBELLIA_2714 ZOBELLIA_2714 3175556 3176761 + Saccharopine dehydrogenase (NADP(+)%2C L-lysine-forming) The Saccharopine dehydrogenase (NADP(+)%2C L-lysine-forming) also called Lysine-2-oxoglutarate reductase converts the N(6)-(L-1%2C3-dicarboxypropyl)-L-lysine (Saccharopine) to L-lysine and 2-oxoglutarate in the metabolism of lysine%3B Belongs to the AlaDH/PNT (Alanine dehydrogenase/Pyridine nucleotide transhydrogenase) family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2714 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2714 ZOBELLIA_2715 ZOBELLIA_2715 ZOBELLIA_2715 3176844 3177956 - Conserved hypothetical periplasmic protein Possible phosphoesterase containing an N-terminal PHP (Polymerase and Histidinol Phosphatase) domain%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2715 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2715 ZOBELLIA_2716 ZOBELLIA_2716 ZOBELLIA_2716 3178025 3178696 - Conserved hypothetical membrane protein Contains six transmembrane segments%3B Belongs to the DUF (domain of unknown function) 1361 family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2716 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2716 ZOBELLIA_2717 ZOBELLIA_2717 ZOBELLIA_2717 3178775 3179134 + Conserved hypothetical protein Belongs to the DUF (domain of unknown function) 1801 family%3B Localized in the cytoplasm%3B~Family membership gene gene2717 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2717 ZOBELLIA_2718 ZOBELLIA_2718 ZOBELLIA_2718 3179135 3180724 - Conserved hypothetical membrane protein Contains 8 PepSY-associated transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2718 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2718 ZOBELLIA_2719 ZOBELLIA_2719 ZOBELLIA_2719 3180730 3181032 - Conserved hypothetical membrane protein Contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2719 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2719 ZOBELLIA_272 ZOBELLIA_272 ZOBELLIA_272 358648 360237 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Would contain a lipoprotein signal peptide cleaved between the residues 24 and 25%3B Probably localized in the outer membrane%3B~Family membership gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_272 ZOBELLIA_2720 ZOBELLIA_2720 ZOBELLIA_2720 3181037 3181369 - Conserved hypothetical membrane protein Contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2720 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2720 ZOBELLIA_2721 ZOBELLIA_2721 ZOBELLIA_2721 3181379 3182116 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2721 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2721 ZOBELLIA_2722 ZOBELLIA_2722 ZOBELLIA_2722 3182207 3184552 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (22-98) and the Plug module (133-232) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene2722 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2722 ZOBELLIA_2723 ZOBELLIA_2723 ZOBELLIA_2723 3184622 3185623 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene2723 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2723 ZOBELLIA_2724 ZOBELLIA_2724 kdsA kdsA 3185635 3186456 - 3-Deoxy-8-phosphooctulonate synthase The 3-Deoxy-8-phosphooctulonate synthase is involved in the biosynthesis of KDO-8P%2C a precursor of lipid A%3B It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate%2C the first step in the biosynthesis of 3-deoxy-D-manno- octulosonate%2C part of the oligosaccharide core of lipopolysaccharide%3B It forms a homotrimer%3B Belongs to the DAHP synthetase I family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2724 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2724 ZOBELLIA_2725 ZOBELLIA_2725 ZOBELLIA_2725 3186540 3187106 + Conserved hypothetical membrane protein Signal peptide cleaved between the residues 21 and 22%3B Putatively localized in the outer membrane%3B~Conserved hypothetical protein gene gene2725 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2725 ZOBELLIA_2726 ZOBELLIA_2726 ZOBELLIA_2726 3187228 3187767 + Conserved hypothetical membrane protein Signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Conserved hypothetical protein gene gene2726 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2726 ZOBELLIA_2727 ZOBELLIA_2727 typA typA 3187958 3189757 + GTP-binding protein TypA TypA is a GTP-binding protein which undergoes tyrosine phosphorylation. Its striking sequence similarity to ribosome-binding elongation factors suggests that it uses a novel mechanism to modulate gene expression%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2727 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2727 ZOBELLIA_2728 ZOBELLIA_2728 ZOBELLIA_2728 3189851 3190768 + Conserved hypothetical lipoprotein Lipoprotein with a signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2728 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2728 ZOBELLIA_2729 ZOBELLIA_2729 ppgK ppgK 3190806 3191555 - Polyphosphate glucokinase Polyphosphate glucokinase catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP%2C UTP and CTP can replace ATP as phosphoryl donor%3B Belongs to the ROK family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2729 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2729 ZOBELLIA_273 ZOBELLIA_273 ZOBELLIA_273 360425 363988 + Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins. The FG-GAP repeat has been predicted to fold into a beta propeller structure. The FG- GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B Contains a signal peptide of lipoprotein cleaved between the residues 21 and 22%3B Protein putatively localized in the cytoplasmic membrane%3B~Function unclear gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_273 ZOBELLIA_2730 ZOBELLIA_2730 idsA2 idsA2 3191636 3193114 - Iduronate-2-sulfatase%2C family S1-7 Iduronate-2-sulfatase%2C called also chondroitinsulfatase is involved in the glycosaminoglycan degradation. It hydrolyzes the 2-sulfate groups from non-reducing-terminal iduronic acid residues in dermatan sulfate%2C heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 7%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2730 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2730 ZOBELLIA_2731 ZOBELLIA_2731 ZOBELLIA_2731 3193154 3193969 - Conserved hypothetical membrane protein Contains an N-terminal transmembrane segments and a putative C-terminal NUDIX (NUcleoside DIphosphate linked to some other moiety X) domain%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2731 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2731 ZOBELLIA_2732 ZOBELLIA_2732 ZOBELLIA_2732 3194063 3195148 - Endonuclease/exonuclease/phosphatase family The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling%3B Belongs to the Endonuclease/Exonuclease/phosphatase family%3B Localized in the cytoplasm%3B~Family membership gene gene2732 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2732 ZOBELLIA_2733 ZOBELLIA_2733 ZOBELLIA_2733 3195307 3195990 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~Family membership gene gene2733 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2733 ZOBELLIA_2734 ZOBELLIA_2734 ZOBELLIA_2734 3196288 3199305 + TPR repeat-containing protein Protein that contains at least ten Tetratricopeptide repeat (TPR) domains involved in the proteinprotein interactions and the assembly of multiprotein complexes%3B Signal peptide cleavbed between the residues 21 and 22%3B Localized in the periplasmic space%3B~Function unclear gene gene2734 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2734 ZOBELLIA_2735 ZOBELLIA_2735 ZOBELLIA_2735 3199404 3201158 + Possible TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene2735 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2735 ZOBELLIA_2736 ZOBELLIA_2736 ZOBELLIA_2736 3201357 3202757 + Monohaem cytochrome C protein Lipoprotein that contains a C-terminal Cytochrome C domain using haem iron as prosthetic group%3B Signal peptide cleaved between the residues 15 and 16%3B Belongs to the monohaem c-type cytochrome family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2736 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2736 ZOBELLIA_2737 ZOBELLIA_2737 ZOBELLIA_2737 3202859 3203980 + OmpA-like periplasmic protein This conserved protein contains a N-terminal module adopting a galactose-binding domain-like fold and a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Family membership gene gene2737 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2737 ZOBELLIA_2738 ZOBELLIA_2738 ZOBELLIA_2738 3203995 3204783 - Conserved hypothetical periplasmic protein Putative signal peptide cleaved between the residues 26 and 27%3B Possibly localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2738 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2738 ZOBELLIA_2739 ZOBELLIA_2739 ZOBELLIA_2739 3204888 3205712 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2739 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2739 ZOBELLIA_274 ZOBELLIA_274 ZOBELLIA_274 364203 365114 + Ppx/GppA-like phosphatase Conserved phosphatase belonging to the Ppx/GppA family%2C which includes exopolyphosphate phosphatase (Ppx) and guanosine pentaphosphate phosphatase (GppA). Its exact specificity is unclear%3B Localized in the cytoplasm%3B~Specificity unclear gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_274 ZOBELLIA_2740 ZOBELLIA_2740 ZOBELLIA_2740 3205779 3206210 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2740 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2740 ZOBELLIA_2741 ZOBELLIA_2741 ZOBELLIA_2741 3206286 3207905 + Amidohydrolase This enzyme could catalyse the hydrolysis of amide or amine bonds in various substrates. This protein adopts a classical alpha-beta TIM-barrel fold. The active site is located in the mouth of the enzyme barrel and contains a bound iron ion that coordinates a hydroxyl nucleophile%3B Belongs to the Amidohydrolase family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Specificity unclear gene gene2741 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2741 ZOBELLIA_2742 ZOBELLIA_2742 ZOBELLIA_2742 3207964 3208512 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2742 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2742 ZOBELLIA_2743 ZOBELLIA_2743 asnB1 asnB1 3208752 3210416 + Asparagine synthase B Asparagine synthase (glutamine-hdrolysing) catalyses the conversion of aspartate to asparagine from glutamine as amido-N-donor. Contains a N-terminal class-2 glutamine amidotransferase domain (GATase domain). Forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2743 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2743 ZOBELLIA_2744 ZOBELLIA_2744 ZOBELLIA_2744 3210500 3210658 - Putative protein Hypothetical protein gene gene2744 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2744 ZOBELLIA_2745 ZOBELLIA_2745 gyrB gyrB 3210769 3212721 + DNA gyrase%2C subunit B DNA gyrase or Topoisomerase II introduces negative supercoils into closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double- stranded DNA rings%2C including catenanes and knotted rings. It is a A2B2 heterotetramer%2C the A subunit being responsible for DNA breakage and rejoining%3B the B chain catalyzing ATP hydrolysis%3B Belongs to the type II topoisomerase family%2C type IIA subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2745 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2745 ZOBELLIA_2746 ZOBELLIA_2746 ZOBELLIA_2746 3212809 3212922 + Putative protein Hypothetical protein gene gene2746 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2746 ZOBELLIA_2747 ZOBELLIA_2747 ZOBELLIA_2747 3213160 3213534 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2747 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2747 ZOBELLIA_2748 ZOBELLIA_2748 mdh mdh 3213888 3214814 + Malate dehydrogenase Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. It uses NAD+ as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2748 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2748 ZOBELLIA_2749 ZOBELLIA_2749 secD secD 3214971 3217952 + Protein-export membrane protein secD SecD is part of the preprotein translocase complex of type II protein secretion system. This complex comprises 7 proteins%2C including a chaperone protein (SecB)%2C an ATPase (SecA)%2C an integral membrane complex (SecC%2C SecE and SecG)%2C and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF)%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2749 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2749 ZOBELLIA_275 ZOBELLIA_275 ZOBELLIA_275 365336 365440 + Putative protein Hypothetical protein gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_275 ZOBELLIA_2750 ZOBELLIA_2750 ZOBELLIA_2750 3218074 3219315 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Contains a duplicated ATPase domain%3B Belongs to the ABC transporter family%2C EF3 subfamily%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~Family membership gene gene2750 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2750 ZOBELLIA_2751 ZOBELLIA_2751 ZOBELLIA_2751 3219898 3224184 - PKD repeats containing lipoprotein Conserved protein containing C-terminal PKD repeats. Contains a prokaryotic lipoprotein signal peptide cleavage between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2751 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2751 ZOBELLIA_2752 ZOBELLIA_2752 ZOBELLIA_2752 3224460 3224978 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene2752 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2752 ZOBELLIA_2753 ZOBELLIA_2753 ZOBELLIA_2753 3224985 3225473 - Conserved hypothetical protein Conserved protein belonging to the DUF192 family. Localized in the cytoplasm.%3B~Family membership gene gene2753 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2753 ZOBELLIA_2754 ZOBELLIA_2754 lgtA lgtA 3225572 3226534 - Prolipoprotein diacylglyceryl transferase Prolipoprotein diacylglyceryl transferase catalyzes the first step in lipoprotein biogenesis%2C it transfers the n-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2754 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2754 ZOBELLIA_2755 ZOBELLIA_2755 ZOBELLIA_2755 3226672 3226881 - Conserved hypothetical protein Conserved protein belonging to the DUF37 family%3B Localized in the cytoplasm%3B~Family membership gene gene2755 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2755 ZOBELLIA_2756 ZOBELLIA_2756 ZOBELLIA_2756 3227037 3227408 - Conserved hypothetical protein Conserved protein belonging to the DUF779 family. Localized in the cytoplasm.%3B~Family membership gene gene2756 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2756 ZOBELLIA_2757 ZOBELLIA_2757 ZOBELLIA_2757 3227410 3228930 - NAD dependent aldehyde dehydrogenase Aldehyde dehydrogenases are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this family%3B Located in the cytoplasm.%3B~Family membership gene gene2757 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2757 ZOBELLIA_2758 ZOBELLIA_2758 ZOBELLIA_2758 3229153 3230070 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene2758 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2758 ZOBELLIA_2759 ZOBELLIA_2759 cysS cysS 3230084 3231562 - Cysteinyl-tRNA synthetase Cysteinyl-tRNA synthetase catalyzes the attachment of cysteine to its cognate transfer RNA molecule in a highly specific two-step reaction. It is a monomer and belongs to the class I of the aminoacyl-tRNA synthetases. It binds one zinc ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2759 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2759 ZOBELLIA_276 ZOBELLIA_276 ZOBELLIA_276 365444 365752 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_276 ZOBELLIA_2760 ZOBELLIA_2760 folE1 folE1 3231578 3232258 - GTP cyclohydrolase I GTP cyclohydrolase I catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate. FolE is a homodecamer%2C composed of a dimer of pentamers. It is an allosteric enzyme%2C whose activity is modulated by K(+)%2C divalent cations%2C UTP%2C and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2760 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2760 ZOBELLIA_2761 ZOBELLIA_2761 ZOBELLIA_2761 3232459 3234261 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2761 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2761 ZOBELLIA_2762 ZOBELLIA_2762 ZOBELLIA_2762 3234382 3235806 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2762 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2762 ZOBELLIA_2763 ZOBELLIA_2763 ZOBELLIA_2763 3235854 3237371 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2763 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2763 ZOBELLIA_2764 ZOBELLIA_2764 ZOBELLIA_2764 3237411 3238634 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene2764 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2764 ZOBELLIA_2765 ZOBELLIA_2765 proS proS 3238731 3240206 + Prolyl-tRNA synthetase Prolyl-tRNA synthetase catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). It forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2765 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2765 ZOBELLIA_2768 ZOBELLIA_2768 rpsT rpsT 3240567 3240818 + Ribosomal protein S20 The ribosomal protein S20 is a part of the ribosomal small subunit. 30S ribosomal protein S20 binds directly to 16S ribosomal RNA%3B Belongs to the ribosomal protein S20P family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2768 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2768 ZOBELLIA_2769 ZOBELLIA_2769 ZOBELLIA_2769 3240897 3241583 - Conserved hypothetical membrane protein Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2769 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2769 ZOBELLIA_277 ZOBELLIA_277 ZOBELLIA_277 365829 367109 + Sugar isomerase Conserved protein belonging to the xylose isomerase family. Its exact specificity is unclear. Localized in the cytoplasm.%3B~Specificity unclear gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_277 ZOBELLIA_2770 ZOBELLIA_2770 ZOBELLIA_2770 3241616 3242377 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2770 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2770 ZOBELLIA_2771 ZOBELLIA_2771 rho rho 3242648 3244321 - Transcription termination factor Rho The Rho factor facilitates transcription termination by a mechanism that involves rho binding to the nascent RNA%2C activation of rho's RNA-dependent ATPase activity%2C and release of the mRNA from the DNA template. RNA-dependent NTPAse which utilizes all four ribonucleoside triphosphates as substrates. It forms a homohexamer.%3B~High confidence in function and specificity gene gene2771 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2771 ZOBELLIA_2772 ZOBELLIA_2772 ZOBELLIA_2772 3244515 3244925 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2772 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2772 ZOBELLIA_2773 ZOBELLIA_2773 ZOBELLIA_2773 3244985 3245479 - Metallophosphoesterase Conserved protein belonging to the metallophosphoesterase family. The most conserved regions in this superfamily centre around the metal chelating residues. Localized in the cytoplasm.%3B~Specificity unclear gene gene2773 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2773 ZOBELLIA_2774 ZOBELLIA_2774 truA1 truA1 3245594 3246346 + tRNA pseudouridine synthase A tRNA pseudouridine synthase is responsible for the formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer-RNAs. Pseudouridine is an isomer of uridine (5-(beta-D- ribofuranosyl) uracil%2C and id the most abundant modified nucleoside found in all cellular RNAs. TruA contains one atom of zinc essential for its native conformation and tRNA recognition and has a strictly conserved aspartic acid that is likely to be involved in catalysis. It forms a dimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2774 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2774 ZOBELLIA_2775 ZOBELLIA_2775 ZOBELLIA_2775 3246339 3248105 + ABC-1 type exporter%2C ATP-binding/permease protein The ABC-1 type transporters have their ABC membrane domain and their ABC ATPase domain fused in the same protein. They are involved in the efflux of compounds across the biological membranes or in targeting of membrane components%3B Contains six N-terminal transmembrane segments (ABC membrane) that form a pore in the cytoplasmic membrane an a C-terminal ATP-binding domain (ABC ATPase) responsible for energy generation%3B Belongs to the ABC-1 type transporter permease/ATP-binding family%2C lipid exporter subfamily (msbA subfamily)%3B~Family membership gene gene2775 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2775 ZOBELLIA_2776 ZOBELLIA_2776 ZOBELLIA_2776 3248106 3248894 - DUF147 family protein The function of DUF147 family proteins is unknown%2C but the distribution of conserved histidines and aspartates suggests that these proteins may be metal dependent phosphoesterases. Features three transmembrane helices in the N-terminal region. Localized in the cytoplasmic membrane.%3B~Family membership gene gene2776 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2776 ZOBELLIA_2777 ZOBELLIA_2777 folP folP 3248938 3249765 - Dihydropteroate synthase Dihydropteroate synthase catalyzes the condensation of 6-hydroxymethyl-7%2C8-dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7%2C8-dihydropteroate. This is the second step in the three-step pathway leading from 6-hydroxymethyl-7%2C8-dihydropterin to 7%2C8-dihydrofolate. It is implicated in resistance to sulfonamide. It forms a homodimer. Localized in the cytoplasm.%3B~Hypothetical protein gene gene2777 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2777 ZOBELLIA_2778 ZOBELLIA_2778 ZOBELLIA_2778 3249872 3250420 + DUF1599 family protein Conserved protein containing two consecutive domains belonging to the DUF1599 family . Localized in the cytoplasm.%3B~Family membership gene gene2778 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2778 ZOBELLIA_2779 ZOBELLIA_2779 ZOBELLIA_2779 3250422 3251519 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2779 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2779 ZOBELLIA_278 ZOBELLIA_278 ZOBELLIA_278 367431 368843 + Conserved hypothetical membrane protein Contains eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_278 ZOBELLIA_2780 ZOBELLIA_2780 tpiA tpiA 3251572 3252321 + Triosephosphate isomerase Triosephosphate isomerase (TIM) catalyzes the reversible interconversion of the dihydroxyacetone phosphate to D-glyceraldehyde 3-phosphate in the fifth step of the glycolysis (Embden-Meyerhof pathway). TIM plays an important role in several metabolic pathways and is essential for efficient energy production. It is a homodimer. A glutamic acid residue is involved in the catalytic mechanism%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2780 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2780 ZOBELLIA_2781 ZOBELLIA_2781 prmA prmA 3252483 3253319 + Ribosomal protein L11 methyltransferase PrmA methylates ribosomal protein L11. Uses S-adenosylmethionine as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2781 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2781 ZOBELLIA_2782 ZOBELLIA_2782 clpS clpS 3253349 3253624 + ATP-dependent Clp protease adapter protein ClpS ClpS is involved in the modulation of the specificity of the clpAP-mediated ATP-dependent protein degradation. It binds to the N-terminal domain of the chaperone ClpA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2782 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2782 ZOBELLIA_2783 ZOBELLIA_2783 ZOBELLIA_2783 3253645 3254058 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2783 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2783 ZOBELLIA_2784 ZOBELLIA_2784 ZOBELLIA_2784 3254058 3254618 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2784 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2784 ZOBELLIA_2785 ZOBELLIA_2785 ZOBELLIA_2785 3254783 3255136 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2785 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2785 ZOBELLIA_2786 ZOBELLIA_2786 ZOBELLIA_2786 3255123 3256109 + Transposase%2C family 12 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 12 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene2786 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2786 ZOBELLIA_2787 ZOBELLIA_2787 ZOBELLIA_2787 3256119 3256214 + Putative protein Hypothetical protein gene gene2787 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2787 ZOBELLIA_2789 ZOBELLIA_2789 apt apt 3256416 3256928 + Adenine phosphoribosyltransferase Adenine phosphoribosyltransferase catalyzes a purine salvage reaction resulting in the formation of AMP%2C that is energically less costly than de novo synthesis. Forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2789 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2789 ZOBELLIA_279 ZOBELLIA_279 ZOBELLIA_279 369097 369837 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_279 ZOBELLIA_2790 ZOBELLIA_2790 ZOBELLIA_2790 3257633 3258571 + Sodium/calcium exchanger Conserved protein belonging to the Sodium/calcium exchanger family. These permeases regulate intracellular Ca2+ concentrations. Features ten transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene2790 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2790 ZOBELLIA_2791 ZOBELLIA_2791 glnII glnII 3258899 3259915 - Glutamine synthetase II Glutamine synthetase (GS)%2C also known as Glutamate-ammonia ligase%2C plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. Belongs to the GS class II which is usually found in eukaryotes and in bacteria belonging to the Rhizobiaceae%2C Frankiaceae%2C and Streptomycetaceae families. GSII are octamer of identical subunits. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2791 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2791 ZOBELLIA_2792 ZOBELLIA_2792 glnA glnA 3260127 3262313 + Glutamine synthetase Glutamine synthetase (GS)%2C also known as Glutamate-ammonia ligase%2C plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. Belongs to the GS class III which includes GS from Bacteroides fragilis and Butyrivibrio fibrisolvens. GSIII enzymes are much larger (about 700 amino acids) than the GSI (450 to 470 amino acids) or GSII (350 to 420 amino acids) enzymes. It forms a hexamer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2792 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2792 ZOBELLIA_2793 ZOBELLIA_2793 ZOBELLIA_2793 3262433 3263281 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2793 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2793 ZOBELLIA_2794 ZOBELLIA_2794 purM purM 3263366 3264547 + Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase is involved in purine biosynthesis. It catalyzes the reaction: ATP + 2-(formamido)-N1-(5-phospho-D- ribosyl)acetamidine %3D ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2794 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2794 ZOBELLIA_2795 ZOBELLIA_2795 ZOBELLIA_2795 3264598 3265047 + Rieske [2Fe-2S] iron-sulfur protein Protein that contains an unknown function N-terminal domain and a C-terminal Rieske [2Fe-2S] domain%3B The rieske domain has a [2Fe-2S] centre. Two conserved cysteines that one Fe ion while the other Fe ion is coordinated by two conserved histidines%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Function unclear gene gene2795 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2795 ZOBELLIA_2796 ZOBELLIA_2796 ZOBELLIA_2796 3265076 3265507 + Thioredoxin family protein Conserved protein belonging to the thioredoxin family. Thioredoxins are small proteins of approximately one hundred amino-acid residues which participate in various redox reactions via the reversible oxidation of an active center disulfide bond. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm.%3B~Family membership gene gene2796 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2796 ZOBELLIA_2797 ZOBELLIA_2797 apbE2 apbE2 3265508 3266497 + Thiamine biosynthesis protein apbE ApbE is involved in the conversion of aminoimidazole ribotide (AIR)%2C a purine intermediate%2C to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2797 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2797 ZOBELLIA_2798 ZOBELLIA_2798 prfA prfA 3266593 3267669 + Peptide chain release factor 1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. It possess a peptidyl-tRNA hydrolase activity. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2798 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2798 ZOBELLIA_2799 ZOBELLIA_2799 pyrF pyrF 3267715 3268524 + Orotidine 5'-phosphate decarboxylase Orotidine 5'-phosphate decarboxylase catalyzes the last step in the de novo biosynthesis of pyrimidines%2C the decarboxylation of Orotidine 5'-phosphate into UMP. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2799 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2799 ZOBELLIA_28 ZOBELLIA_28 ZOBELLIA_28 27805 28497 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity (here a LytTR-type HTH domain)%2C which acts as transcriptional regulator%3B Localized in the cytoplasm%3B~Family membership gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_28 ZOBELLIA_280 ZOBELLIA_280 ZOBELLIA_280 370016 370942 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons. Contains two C-terminal AraC-type HTH DNA-binding domains involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization. Localized in the cytoplasm.%3B~Specificity unclear gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_280 ZOBELLIA_2800 ZOBELLIA_2800 ZOBELLIA_2800 3268537 3268641 - Putative protein Hypothetical protein gene gene2800 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2800 ZOBELLIA_2801 ZOBELLIA_2801 ZOBELLIA_2801 3269121 3269912 + Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices Belongs to alpha/beta hydrolase superfamily%3B Contains a central transmembrane segment delimiting a cytoplasmic N-terminal part and a periplasmic C-terminal part%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene2801 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2801 ZOBELLIA_2802 ZOBELLIA_2802 ZOBELLIA_2802 3269921 3270016 + Putative protein Hypothetical protein gene gene2802 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2802 ZOBELLIA_2803 ZOBELLIA_2803 ZOBELLIA_2803 3270172 3270876 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene2803 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2803 ZOBELLIA_2804 ZOBELLIA_2804 purU purU 3270962 3271813 - Formyltetrahydrofolate deformylase Formyltetrahydrofolate deformylase produces formate from formyl-tetrahydrofolate. Provides the major source of formate for the purT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide during aerobic growth. Has a role in regulating the one-carbon pool. purU forms a hexamer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2804 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2804 ZOBELLIA_2805 ZOBELLIA_2805 ZOBELLIA_2805 3271902 3272315 - Conserved hypothetical protein Localized in the cytoplasm gene gene2805 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2805 ZOBELLIA_2806 ZOBELLIA_2806 ZOBELLIA_2806 3272442 3272888 + AsnC/Lrp-type transcriptional regulator The AsnC/Lrp-type transcriptional regulator family appears to be an important regulatory system of the amino acid metabolism and related processes%3B Contains a N-terminal DNA binding AsnC/Lrp-type HTH domain. The C-terminal part contains an effector-binding domain and/or an oligomerization domain%3B Localized in the cytoplasm%3B~Family membership gene gene2806 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2806 ZOBELLIA_2807 ZOBELLIA_2807 ZOBELLIA_2807 3272995 3275064 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2807 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2807 ZOBELLIA_2808 ZOBELLIA_2808 ZOBELLIA_2808 3275170 3275994 + Small-conductance mechanosensitive channel Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains three transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2808 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2808 ZOBELLIA_2809 ZOBELLIA_2809 ZOBELLIA_2809 3276074 3277486 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2809 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2809 ZOBELLIA_281 ZOBELLIA_281 ZOBELLIA_281 371305 371970 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_281 ZOBELLIA_2810 ZOBELLIA_2810 ZOBELLIA_2810 3277492 3278229 - Family C56 non-peptidase protein Protein belonging to the family 56 of the cysteine peptidases (C56)%2C but lacks the catalytic diad Cys-His%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Function unclear gene gene2810 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2810 ZOBELLIA_2811 ZOBELLIA_2811 ZOBELLIA_2811 3278314 3278964 + Conserved hypothetical protein Protein containing a domain of unknown function DUF 1684%3B Localized in the cytoplasm%3B~Family membership gene gene2811 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2811 ZOBELLIA_2812 ZOBELLIA_2812 ZOBELLIA_2812 3279042 3280109 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2812 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2812 ZOBELLIA_2813 ZOBELLIA_2813 amtB amtB 3280224 3281456 - Ammonia channel AmtB is a membrane channel involved in the uptake of ammonia (NH4+). It forms a homotrimer and the monomeric subunit features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2813 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2813 ZOBELLIA_2814 ZOBELLIA_2814 glnB glnB 3281484 3281822 - Nitrogen regulatory protein P-II P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP%2C these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP%2C which causes the deadenylation of glutamine synthetase by glnE%2C so activating the enzyme%3B Forms a homotrimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2814 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2814 ZOBELLIA_2815 ZOBELLIA_2815 ZOBELLIA_2815 3281853 3281984 + Putative protein Hypothetical protein gene gene2815 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2815 ZOBELLIA_2816 ZOBELLIA_2816 crcB crcB 3282115 3282486 - Protein CrcB The exact function of CrcB is not known. But its overproduction leads to camphor resistance and chromosome condensation. Its deletion increases sensibility to nucleoid decondensation. Probably interacts with the heat-shock protein cspE%2C possibly providing a way to anchor the chromosome to the membrane. Features four transmembrane helices. Localized in the cytoplasmic membrane.%3B~Function unclear gene gene2816 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2816 ZOBELLIA_2817 ZOBELLIA_2817 ZOBELLIA_2817 3282970 3283098 + Putative protein Hypothetical protein gene gene2817 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2817 ZOBELLIA_2818 ZOBELLIA_2818 ZOBELLIA_2818 3283095 3283481 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2818 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2818 ZOBELLIA_2819 ZOBELLIA_2819 ilvE ilvE 3283585 3284649 - Branched-chain-amino-acid aminotransferase Branched-chain-amino-acid aminotransferase is involved in leucine%2C isoleucine and valine biosynthesis from L-glutamic acid%3B It forms a homohexamer and used one Pyridoxal phosphate as cofactor per subunit%3B Belongs to the Aminotransferase class IV%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2819 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2819 ZOBELLIA_282 ZOBELLIA_282 ZOBELLIA_282 372015 372404 - Conserved hypothetical protein Localized in the cytoplasm. gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_282 ZOBELLIA_2820 ZOBELLIA_2820 ZOBELLIA_2820 3284755 3285249 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene2820 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2820 ZOBELLIA_2821 ZOBELLIA_2821 ZOBELLIA_2821 3285251 3285910 + DUF752 family protein Conserved protein belonging to the DUF752 family. Localized in the cytoplasm.%3B~Conserved hypothetical protein gene gene2821 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2821 ZOBELLIA_2822 ZOBELLIA_2822 ZOBELLIA_2822 3286038 3287003 + NAD(P)-dependent epimerase/dehydratase Conserved protein belonging to the NAD(P)-dependent epimerase/dehydratase family. Adopts a Rossmann fold. Localized in the cytoplasm.%3B~Function unclear gene gene2822 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2822 ZOBELLIA_2823 ZOBELLIA_2823 grpE grpE 3287206 3287769 + Co-chaperone HSP-70 protein Dimeric GrpE is a co-chaperone for the molecular chaperone DnaK. Acts as a nucleotide exchange factor and may function as a thermosensor%3B~High confidence in function and specificity gene gene2823 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2823 ZOBELLIA_2824 ZOBELLIA_2824 dnaJ dnaJ 3287779 3288897 + Co-chaperone protein dnaJ DnaJ is a molecular co-chaperone for the molecular chperone DnaK%3B Besides stimulating the ATPase activity of DnaK through its N-terminal J-domain%2C DnaJ also associates with unfolded polypeptide chains and prevents their aggregation%3B DnaJ has been shown to bind both L- and D-peptides and is assumed to interact only with the side chains of the substrate. Contains a N-terminal J-domain (interaction with DnaK)%2C a C-terminal domain (unknown function) and a central cystein rich module%3B~High confidence in function and specificity gene gene2824 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2824 ZOBELLIA_2825 ZOBELLIA_2825 ZOBELLIA_2825 3289081 3290019 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene2825 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2825 ZOBELLIA_2826 ZOBELLIA_2826 ZOBELLIA_2826 3290012 3291340 + ABC-2 type exporter%2C permease component Putatif ABC-2 type (ATP-binding cassette) transporter%2C membrane domain possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics%2C heavy metals or solvents across biological membranes%3B Contains seven transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2826 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2826 ZOBELLIA_2827 ZOBELLIA_2827 ZOBELLIA_2827 3291325 3292236 + Small-conductance mechanosensitive channel Mechanosensitive channels (MS) provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains four transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2827 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2827 ZOBELLIA_2828 ZOBELLIA_2828 ZOBELLIA_2828 3292355 3293134 + Conserved hypothetical protein Localized in the cytoplasm gene gene2828 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2828 ZOBELLIA_2829 ZOBELLIA_2829 ZOBELLIA_2829 3293147 3294310 + Sigma-54 dependent two-component system-Response regulator These response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes%2C activating the expression of genes from factor sigma-54 specific promoters. These proteins consist of two domains%2C an N- terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a C- terminal domain that interacts with the sigma 54 factor%3B~Family membership gene gene2829 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2829 ZOBELLIA_283 ZOBELLIA_283 ZOBELLIA_283 373155 373676 - Hypothetical protein Localized in the cytoplasm gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_283 ZOBELLIA_2830 ZOBELLIA_2830 ZOBELLIA_2830 3294320 3295021 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2830 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2830 ZOBELLIA_2831 ZOBELLIA_2831 ppk2 ppk2 3295223 3296107 + Polyphosphate kinase 2 Ppk2 was first identified in Pseudomonas aeruginosa by Zhang and cowokers (PNAS%2C 2006). Ppk2 belongs to a polyphosphate kinase family unrelated to that of Ppk1. Pkk2 also distinguished from PPK1 by the following: synthesis of poly P from GTP or ATP%2C a preference for Mn2+ over Mg2+%2C and a stimulation by poly P. The reverse reaction%2C a poly P-driven nucleoside diphosphate kinase synthesis of GTP from GDP%2C is 75-fold greater than the forward reaction%2C poly P synthesis from GTP. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2831 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2831 ZOBELLIA_2832 ZOBELLIA_2832 ZOBELLIA_2832 3296104 3297498 + Metallopeptidase%2C family M28 Family M28 contains aminopeptidases and carboxypeptidases with two co-catalytic zinc ions (I and II). Each zinc ion is tetrahedrally co-ordinated%2C with three amino acid ligands plus activated water%3B one aspartate residue binds both metal ions. The zinc ligands occur in the sequence in the order His (II)%2C Asp (I and II)%2C Glu (I)%2C Asp or Glu (II) and His (I). In addition%2C two other residues%2C an Asp and a Glu%2C are believed to be important for catalysis. Four of these residues occur in the motifs His-Xaa-Asp and Glu-Glu. Features a signal peptide cleaved between the residues 20 and 21. Localized in the periplasm.%3B~Specificity unclear gene gene2832 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2832 ZOBELLIA_2833 ZOBELLIA_2833 ppiB ppiB 3297648 3298580 + Peptidyl-prolyl cis-trans isomerase Peptidyl-prolyl cis-trans isomerase%2C or PPIase or rotamase%2C accelerates the folding of proteins. It catalyzes the peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation in oligopeptides%3B Contains a N-terminal Cyclophilin type PPIase/CLD and a C-terminal FKBP-type peptidyl-prolyl cis- trans isomerase%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2833 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2833 ZOBELLIA_2834 ZOBELLIA_2834 cspA3 cspA3 3299085 3299279 - Cold shock protein CspA Cold shock proteins (CSPs) help the cell to survive in temperatures lower than optimum growth temperature. CSPs may act as RNA chaperones by destabilizing RNA secondary structures%2C regulating ribosomal translation%2C rate of mRNA degradation and termination of transcription%3B Contains a 'cold-shock domain' (CSD) involved in the single-strand nucleic-acid binding%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2834 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2834 ZOBELLIA_2835 ZOBELLIA_2835 ZOBELLIA_2835 3299640 3300278 - Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~Specificity unclear gene gene2835 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2835 ZOBELLIA_2836 ZOBELLIA_2836 yfiT yfiT 3300349 3300936 + Putative metal-dependent hydrolase YfiT YfiT exists as a dimer and binds Ni(2+) in a 1:1 stoichiometry. The protein has an unusual four-helix bundle topology and coordinates Ni(2+) in an octahedral geometry with three conserved histidines and three waters. Although there is no similarity in their overall structures%2C the coordination geometry of the metal and the residues that constitute the putative active site in YfiT are%3B~Function unclear gene gene2836 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2836 ZOBELLIA_2837 ZOBELLIA_2837 ZOBELLIA_2837 3300947 3301504 - Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~Family membership gene gene2837 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2837 ZOBELLIA_2838 ZOBELLIA_2838 csaA csaA 3301617 3301955 + Protein CsaA CsaA could serves as a molecular chaperone for exported proteins or alternatively acts by stabilizing the secA protein. Belongs to a putative tRNA binding domain family. Localized in the cytoplasm.%3B~Function unclear gene gene2838 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2838 ZOBELLIA_2839 ZOBELLIA_2839 ZOBELLIA_2839 3301960 3302880 + Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2839 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2839 ZOBELLIA_284 ZOBELLIA_284 ZOBELLIA_284 374197 374724 + Hypothetical protein Localized in the cytoplasm gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_284 ZOBELLIA_2840 ZOBELLIA_2840 ZOBELLIA_2840 3302877 3303920 + Acyltransferase Acyltransferase of unkown specificity. This family also incluses acyltransferases involved in phospholipid biosynthesis. Features a C-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene2840 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2840 ZOBELLIA_2841 ZOBELLIA_2841 ZOBELLIA_2841 3303996 3304376 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2841 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2841 ZOBELLIA_2842 ZOBELLIA_2842 mdlA mdlA 3304449 3306203 - Multidrug resistance-like%2C ATP-binding/permease protein Possibly involved in the multidrug resistance by toxic compounds export%3B Contains six N-terminal transmembrane segments (ABC membrane) that form a pore in the cytoplasmic membrane an a C-terminal ATP-binding domain (ABC ATPase) responsible for energy generation%3B Belongs to the ABC-1 type transporter permease/ATP-binding family%2C MDR subfamily%3B~High confidence in function and specificity gene gene2842 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2842 ZOBELLIA_2843 ZOBELLIA_2843 nusB nusB 3306558 3307472 + N utilization substance protein B NusB is a transcription factor involved in antitermination processes%2C during which it interacts with the boxA portion of the mRNA nut site. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2843 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2843 ZOBELLIA_2844 ZOBELLIA_2844 ZOBELLIA_2844 3307513 3307983 + Conserved hypothetical membrane protein Protein that contains a domain of unknown function DUF1573%3B Putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Family membership gene gene2844 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2844 ZOBELLIA_2845 ZOBELLIA_2845 yajC yajC 3308008 3308295 + Preprotein translocase subunit Part of the secDF-yidC-yajC translocase complex. YajC is also present in a homo-oligomeric complex in excess of the other components. Contains one N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene2845 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2845 ZOBELLIA_2846 ZOBELLIA_2846 ZOBELLIA_2846 3308408 3309757 + NAD(P)-dependent dehydrogenase%2C exported NAD(P)-dependent dehydrogenase. Belongs to the Rossmann fold family. Features a twin-arginine translocation signal peptide.%3B~Function unclear gene gene2846 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2846 ZOBELLIA_2847 ZOBELLIA_2847 ZOBELLIA_2847 3310024 3310236 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2847 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2847 ZOBELLIA_2848 ZOBELLIA_2848 pepT pepT 3310281 3311510 - Tripeptide aminopeptidase%2C family M20 Tripeptide aminopeptidase releases the N-terminal amino acid from tripeptides. Has a preference for tripeptides containing a N-terminal methionine or leucine. Belongs to the family 20 of the metallopeptidases. PepT binds two co-catalytic zinc ions%2C which are coordinated by five conserved residues (His/Asp%2C Asp%2C Glu%2C Glu/Asp%2C His). The zinc ions stabilize the tetrahedral intermediate and activate the catalytic water molecule. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2848 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2848 ZOBELLIA_2849 ZOBELLIA_2849 ZOBELLIA_2849 3311655 3314636 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-92) and the Plug module (109-232) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene2849 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2849 ZOBELLIA_285 ZOBELLIA_285 ZOBELLIA_285 375233 375895 - Hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_285 ZOBELLIA_2850 ZOBELLIA_2850 ZOBELLIA_2850 3314757 3315221 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2850 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2850 ZOBELLIA_2851 ZOBELLIA_2851 pyrD pyrD 3315348 3316391 + Dihydroorotate dehydrogenase Dihydroorotate dehydrogenase catalyzes the fourth step in the de novo biosynthesis of pyrimidine%2C the conversion of dihydroorotate into orotate. It forms a homodimer and binds one FMN as cofactor pare subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2851 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2851 ZOBELLIA_2852 ZOBELLIA_2852 ZOBELLIA_2852 3316423 3316842 - Conserved hypothetical periplasmic protein Contains a dimeric alpha-beta barrel domain possibly involved in the stress response%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2852 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2852 ZOBELLIA_2853 ZOBELLIA_2853 rhtB rhtB 3317069 3317695 + Homoserine/homoserine lactone efflux protein RthB conducts the efflux of homoserine and homoserine lactone. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2853 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2853 ZOBELLIA_2854 ZOBELLIA_2854 mvaB mvaB 3317754 3318620 + Hydroxymethylglutaryl-CoA lyase Hydroxymethylglutaryl-CoA lyase is involved in mevalonate catabolism. It cleaves the (S)-3-hydroxy-3-methylglutaryl-CoA to acetyl-CoA and acetoacetate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2854 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2854 ZOBELLIA_2855 ZOBELLIA_2855 ZOBELLIA_2855 3318617 3318982 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2855 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2855 ZOBELLIA_2856 ZOBELLIA_2856 ZOBELLIA_2856 3319299 3320522 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2856 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2856 ZOBELLIA_2857 ZOBELLIA_2857 ZOBELLIA_2857 3320634 3321764 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2857 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2857 ZOBELLIA_2858 ZOBELLIA_2858 ggcX ggcX 3321768 3323135 + Vitamin K-dependent gamma-glutamyl carboxylase Vitamin K-dependent gamma-glutamyl carboxylase catalyzes the Vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues to gamma-carboxyglutamate in various proteins%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2858 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2858 ZOBELLIA_2859 ZOBELLIA_2859 ZOBELLIA_2859 3323116 3325590 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-99) and the Plug module (130-240) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene2859 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2859 ZOBELLIA_286 ZOBELLIA_286 ZOBELLIA_286 375899 376408 - Conserved hypothetical protein Putatively localized in the cytoplasm. gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_286 ZOBELLIA_2860 ZOBELLIA_2860 ZOBELLIA_2860 3325596 3325718 + Putative protein Hypothetical protein gene gene2860 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2860 ZOBELLIA_2861 ZOBELLIA_2861 guaB guaB 3325802 3327274 + Inosine-5'-monophosphate dehydrogenase Inosine-5'-monophosphate dehydrogenase catalyzes the rate-limiting reaction of de novo GTP biosynthesis%2C the NAD-dependent reduction of IMP into XMP. It also features two N-termianl CBS (cystathionine-beta-synthase) domains. Tandem pairs of CBS domains can act as binding domains for adenosine derivatives and may regulate the activity of attached enzymatic domains. GuaB forms a homotetramer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2861 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2861 ZOBELLIA_2862 ZOBELLIA_2862 ZOBELLIA_2862 3327307 3329874 - Aminopeptidase%2C family M1 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. This enzyme belongs to the family M1 of the peptidases. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Localized in the cytoplasm%3B~Specificity unclear gene gene2862 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2862 ZOBELLIA_2863 ZOBELLIA_2863 ZOBELLIA_2863 3330030 3330554 - Thioredoxin family protein Conserved protein belonging to the thioredoxin family. Thioredoxins are small proteins of approximately one hundred amino-acid residues which participate in various redox reactions via the reversible oxidation of an active center disulfide bond. Features a signal peptide cleaved between the residues 23 and 24. Localized in the periplasm.%3B~Family membership gene gene2863 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2863 ZOBELLIA_2864 ZOBELLIA_2864 lysA lysA 3330615 3331856 - Diaminopimelate decarboxylase Diaminopimelate decarboxylase catalyzes the conversion of diaminopimelic acid into lysine%2C the final step of lysine biosynthesis. Binds pyridoxal phosphate as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2864 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2864 ZOBELLIA_2865 ZOBELLIA_2865 ZOBELLIA_2865 3332023 3332661 + Conserved hypthetical protein Protein displaying weak similarity with the N-terminal non-peptidase domain of the ATP-dependent peptidase LonA%3B Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene2865 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2865 ZOBELLIA_2866 ZOBELLIA_2866 sucC sucC 3332841 3334034 + Succinyl-CoA ligase [ADP-forming] subunit beta Succinyl-CoA ligase functions in the citric acid cycle%2C coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents an important site of substrate-level phosphorylation. It can also function in the other direction for anabolic purposes. It forms a heterotetramer of two alpha and two beta subunits. The alpha subunit binds CoA%2C as well as ATP and catalyzes phosphoryl transfer to one of its histidine residues. The complete active site is probably located in the region of alpha-beta contact. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2866 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2866 ZOBELLIA_2867 ZOBELLIA_2867 ZOBELLIA_2867 3334315 3334659 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2867 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2867 ZOBELLIA_2868 ZOBELLIA_2868 ald1 ald1 3334729 3335814 - Alanine dehydrogenase Alanine dehydrogenase is a key factor in the assimilation of L-alanine as an energy source through the tricarboxylic acid. It catalyzes the reaction: L-alanine + H2O + NAD+ %3D pyruvate + NH3 + NADH. It forms a homohexamer and binds one NAD+ per subunit as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2868 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2868 ZOBELLIA_2869 ZOBELLIA_2869 ZOBELLIA_2869 3335937 3337088 - Hypothetical membrane protein Possible permease that consists to eleven transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2869 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2869 ZOBELLIA_287 ZOBELLIA_287 ZOBELLIA_287 377152 378963 + Conserved hypothetical protein Localized in the cytoplasm. gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_287 ZOBELLIA_2870 ZOBELLIA_2870 hisC2 hisC2 3337201 3338388 - Histidinol-phosphate aminotransferase The histidinol-phosphate aminotransferase catalyses the transfer of an amino group from 3-(imidazol-4-yl)-2-oxopropyl phosphate to glutamic acid to form histidinol phosphate and 2-oxoglutarate using the Pyridoxal phosphate as cofactor bound by covalent linkage to a lysine residue%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B Possibly exported in the periplasmic space by a twin-arginine signal peptide (cleavage site between 32 and 33)%3B~High confidence in function and specificity gene gene2870 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2870 ZOBELLIA_2871 ZOBELLIA_2871 ZOBELLIA_2871 3338422 3339042 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%2C Localized in the outer membrane%3B~Hypothetical protein gene gene2871 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2871 ZOBELLIA_2872 ZOBELLIA_2872 ZOBELLIA_2872 3339080 3342028 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-96) and the Plug module (114-236) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene2872 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2872 ZOBELLIA_2873 ZOBELLIA_2873 asnC1 asnC1 3342589 3343050 + Transcriptional regulator AsnC The transcriptional regulator AsnC is the activator of the asnA gene involved in the asparagine synthesis and is a autogenous regulator of its own transcription%3B Contains a N-terminal AsnC/Lrp-type HTH domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2873 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2873 ZOBELLIA_2874 ZOBELLIA_2874 ZOBELLIA_2874 3343242 3343544 + Conserved hypothetical protein Localized in the cytoplasm gene gene2874 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2874 ZOBELLIA_2875 ZOBELLIA_2875 ZOBELLIA_2875 3343596 3343958 - Conserved hypothetical protein Protein belonging to the DUF1456 family%3B Localized in the cytoplasm gene gene2875 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2875 ZOBELLIA_2876 ZOBELLIA_2876 ZOBELLIA_2876 3344204 3344629 + Small heat shock protein Heat shock protein belonging to the HSP20 family. Acts as chaperone that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Localized in the cytoplasm.%3B~Family membership gene gene2876 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2876 ZOBELLIA_2877 ZOBELLIA_2877 ZOBELLIA_2877 3344804 3344908 + Putative protein Hypothetical protein gene gene2877 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2877 ZOBELLIA_2878 ZOBELLIA_2878 uvrB uvrB 3345022 3347010 - Excinuclease ABC%2C subunit B The UvrB protein belongs to the UvrABC repair system responsible of the recognition and processing of DNA lesions%3B This system is a complex composed of 2 UvrA (ATPase) and 2 UvrB subunits. UvrB is a helicase that probes one DNA strand for the presence of a lesion. If a lesion is found%2C the UvrA subunits dissociate and the UvrB-DNA preincision complex is subsequently bound by UvrC (endonuclease). If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Contains a C-terminal UVR domain that can interact with the homologous domain in UvrC%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2878 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2878 ZOBELLIA_2879 ZOBELLIA_2879 ZOBELLIA_2879 3347364 3347756 + Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2879 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2879 ZOBELLIA_288 ZOBELLIA_288 ZOBELLIA_288 379110 379340 - Putative protein Hypothetical protein gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_288 ZOBELLIA_2880 ZOBELLIA_2880 ZOBELLIA_2880 3348032 3348865 - ABC importer%2C permease component ABC (ATP-binding cassette) transporter%2C membrane domain%3B Proteins responsible for import of a variety of compounds across biological membranes%3B Contains six transmembrane segmemts%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2880 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2880 ZOBELLIA_2881 ZOBELLIA_2881 ZOBELLIA_2881 3348871 3349773 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene2881 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2881 ZOBELLIA_2882 ZOBELLIA_2882 ZOBELLIA_2882 3349842 3351854 - Conserved hypothetical protein Contains a domain of unknown function (DUF 11) and a fragment of 34 residues of Actin-binding like protein (Filamin/ABP280)%3B Signal peptide cleaved betwenn the residues 20 and 21%3B Putatively localized in the outer membrane gene gene2882 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2882 ZOBELLIA_2883 ZOBELLIA_2883 ZOBELLIA_2883 3360691 3360927 + Putative protein Hypothetical protein gene gene2884 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2883 ZOBELLIA_2884 ZOBELLIA_2884 ZOBELLIA_2884 3360953 3361237 + Putative protein Hypothetical protein gene gene2885 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2884 ZOBELLIA_2885 ZOBELLIA_2885 ZOBELLIA_2885 3362402 3362713 + Putative protein Hypothetical protein gene gene2886 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2885 ZOBELLIA_2886 ZOBELLIA_2886 ZOBELLIA_2886 3363035 3363280 + Putative protein Hypothetical protein gene gene2887 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2886 ZOBELLIA_2887 ZOBELLIA_2887 ZOBELLIA_2887 3363445 3363687 + Putative protein Hypothetical protein gene gene2888 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2887 ZOBELLIA_2888 ZOBELLIA_2888 ZOBELLIA_2888 3352042 3364344 - Conserved hypothetical protein Contains a B_ant_repeat domain (DUF 11) in the N-terminal region%3B Shows 56%25 of identity with the N-terminal domain of ORF 609%3B Signal peptide cleaved between the residues 26 and 27%3B Putatively localized in the outer membrane (PSORT result) gene gene2883 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2888 ZOBELLIA_2889 ZOBELLIA_2889 ZOBELLIA_2889 3364512 3365594 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2889 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2889 ZOBELLIA_289 ZOBELLIA_289 ZOBELLIA_289 379419 379751 + Hypothetical membrane protein Contains three transmembrane helices. Localized in the cytoplasmic membrane.%3B~Hypothetical protein gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_289 ZOBELLIA_2890 ZOBELLIA_2890 ZOBELLIA_2890 3365653 3366711 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2890 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2890 ZOBELLIA_2891 ZOBELLIA_2891 ZOBELLIA_2891 3366809 3367303 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2891 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2891 ZOBELLIA_2892 ZOBELLIA_2892 ctaA ctaA 3367331 3368365 - Cytochrome aa3-controlling protein CtaA is required for cytochrome aa3 biosynthesis. Features eight transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2892 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2892 ZOBELLIA_2893 ZOBELLIA_2893 ZOBELLIA_2893 3368446 3370374 - OmpA-like periplasmic protein This protein has a modular architecture consisting of a N-terminal TPR motif%2C a central beta-propeller domain%2C encompassing three WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan. The tetratrico peptide repeat (TPR) is a structural motif%2C which mediates proteinprotein interactions%3B Signal peptide cleaved between the residues 23 and 24%3B localized in the periplasmic space and/or outer membrane%3B~Family membership gene gene2893 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2893 ZOBELLIA_2894 ZOBELLIA_2894 ZOBELLIA_2894 3370376 3371314 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2894 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2894 ZOBELLIA_2895 ZOBELLIA_2895 ZOBELLIA_2895 3371330 3380098 - Conserved hypothetical protein Contains several Single hybrid motifs found in biotinyl/lipoyl-carrier proteins and domains%2C where the biotin and lipoic acid moieties act as covalently attached coenzyme in various enzymes%3B Signal peptide cleaved between the residues 23 and 24%3B Putatively localized in the cytoplasmic membrane gene gene2895 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2895 ZOBELLIA_2896 ZOBELLIA_2896 ZOBELLIA_2896 3380381 3381322 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2896 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2896 ZOBELLIA_2897 ZOBELLIA_2897 ZOBELLIA_2897 3381429 3381539 + Putative protein Hypothetical protein gene gene2897 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2897 ZOBELLIA_2898 ZOBELLIA_2898 cca cca 3381536 3382960 - Multifunctional CCA protein CcA catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C%2C C%2C and A to the tRNA nucleotide-73%2C using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows highest phosphatase activity in the presence of Ni(2+) and hydrolyzes pyrophosphate%2C canonical 5'-nucleoside tri- and diphosphates%2C NADP%2C and 2'-AMP with the production of Pi. Displays a metal-independent phosphodiesterase activity toward 2'%2C3'-cAMP%2C 2'%2C3'-cGMP%2C and 2'%2C3'-cCMP. Without metal or in the presence of Mg(2+)%2C this protein hydrolyzes 2'%2C3'-cyclic substrates with the formation of 2'-nucleotides%2C whereas in the presence of Ni(2+)%2C it also produces some 3'-nucleotides. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2898 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2898 ZOBELLIA_2899 ZOBELLIA_2899 ZOBELLIA_2899 3383022 3383582 - YrdC family protein Conserved protein belonging to the YrdC family . The YrdC protein from E. coli forms an alpha/beta twisted open-sheet structure composed of seven alpha helices and seven beta strands. YrdC was shown to binds double-stranded RNA. Its exact function is unclear. Localized in the cytoplasm.%3B~Function unclear gene gene2899 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2899 ZOBELLIA_29 ZOBELLIA_29 priA priA 28565 31018 - Primosomal protein N' (replication factor Y) The primosomal protein N'%2C or replication factor Y%2C acts as an ATP-dependant DNA helicase within the primosome%3B The Y factor recognizes a specific hairpin sequence on phiX ssDNA. This structure is then recognized and bound by proteins priB and priC. Formation of the primosome proceeds with the subsequent actions of dnaB%2C dnaC%2C dnaT and primase%3B Belongs to the superfamily II of helicases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_29 ZOBELLIA_290 ZOBELLIA_290 ZOBELLIA_290 379907 381655 - Putative cysteine peptidase This protein displays is distantly related to Papain family cysteine peptidases. It also features a conserved motif GAHSVLLVGFD (G246-D256) which is usually typical for the catalytic site of cysteine peptidases (Prosite: PS00639). These enzymes contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain%3B an asparagine completes the essential catalytic triad. This protein is localized in the cytoplasm.%3B~Hypothetical protein gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_290 ZOBELLIA_2900 ZOBELLIA_2900 ZOBELLIA_2900 3383554 3384417 - Conserved hypothetical protein Localized in the cytoplasm gene gene2900 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2900 ZOBELLIA_2901 ZOBELLIA_2901 ZOBELLIA_2901 3384440 3385315 - Conserved hypothetical protein Localized in the cytoplasm gene gene2901 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2901 ZOBELLIA_2902 ZOBELLIA_2902 ZOBELLIA_2902 3385375 3386208 + Glycosyltransferase%2C family GT2 Putatively involved in the exopolysaccharide biosynthesis%3B Belongs to the family 2 of glycosyl transferase (GT2)%3B Localized in the cytoplasm%3B~Family membership gene gene2902 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2902 ZOBELLIA_2903 ZOBELLIA_2903 waaE waaE 3386190 3386984 - Lipopolysaccharide core biosynthesis glycosyltransferase%2C family GT2 Putatively involved in the Lipopolysaccharide core biosynthesis%3B Belongs to the family 2 of glycosyl transferase (GT2)%2C WaaE/kdtX subfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene2903 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2903 ZOBELLIA_2904 ZOBELLIA_2904 dapD dapD 3387138 3387953 - 2%2C3%2C4%2C5-Tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase DapD is involved in L-Lysine and diaminopimelate biosynthesis. It catalyzes the reaction: Succinyl-CoA + (S)-2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate + H2O %3D CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2904 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2904 ZOBELLIA_2905 ZOBELLIA_2905 yqgF yqgF 3388088 3388567 + Holliday junction resolvase Holliday junction resolvases (HJRs) are key enzymes of DNA recombination%3B Could be a nuclease that resolves Holliday junction intermediates in genetic recombination%3B Display a RNase H fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2905 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2905 ZOBELLIA_2906 ZOBELLIA_2906 defA defA 3388568 3389158 + Formylmethionine deformylase Formylmethionine deformylase or peptide deformylase (PDF) is an essential metalloenzyme required for the removal of the formyl group at the N-terminal Met of nascent polypeptide chains in eubacteria. The enzyme acts as a monomer and binds a single zinc ion. Catalytic efficiency strongly depends on the identity of the bound metal%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2906 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2906 ZOBELLIA_2907 ZOBELLIA_2907 ZOBELLIA_2907 3389219 3389638 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene2907 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2907 ZOBELLIA_2908 ZOBELLIA_2908 ZOBELLIA_2908 3389868 3390311 + Expression activator-related protein Protein%2C involved in sensory transduction in microorganisms%2C and that consists of an N-terminal BLUF (sensors of blue-light using FAD) domain. This domain is involved in sensing blue-light (and possibly redox) using FAD and is Localized in the cytoplasm%3B~Function unclear gene gene2908 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2908 ZOBELLIA_2909 ZOBELLIA_2909 ZOBELLIA_2909 3390765 3391853 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains an N- terminal PAS/PAC domain involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene2909 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2909 ZOBELLIA_291 ZOBELLIA_291 ZOBELLIA_291 382261 382722 + Xre-type transcriptional regulator Transcriptional regulator belonging to the Xre family. Features a helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Specificity unclear gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_291 ZOBELLIA_2910 ZOBELLIA_2910 ZOBELLIA_2910 3391869 3392261 + Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene2910 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2910 ZOBELLIA_2911 ZOBELLIA_2911 nahA2 nahA2 3392324 3393940 - Beta-N-acetylhexosaminidase%2C family GH20 Beta-N-acetylhexosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides%3B Belongs to the family 20 of the glycoside hydrolases (GH20)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene2911 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2911 ZOBELLIA_2912 ZOBELLIA_2912 ZOBELLIA_2912 3393976 3394614 - Acetylesterase%2C lipase-GDSL family Converts an acetic ester to an alcohol and acetate%3B Belongs to the SGNH-hydrolase superfamily%2C lipase-GDSL family%2C which includes families 3 and 12 of the carbohydrate esterases (CE3 and CE12)%3B Signal peptide cleaved between the residues 17 and 18%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2912 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2912 ZOBELLIA_2913 ZOBELLIA_2913 ZOBELLIA_2913 3394621 3395496 - Carbohydrate esterase%2C family CE10 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 10 of the carbohydrate esterases (CE10)%3B Signal peptide cleaved between residues 19 and 20%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2913 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2913 ZOBELLIA_2914 ZOBELLIA_2914 glpF glpF 3395535 3396260 - Glycerol uptake facilitator protein Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane. Belongs to the Major Intrinsinc Protein family which also includes aquaporin. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2914 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2914 ZOBELLIA_2915 ZOBELLIA_2915 ZOBELLIA_2915 3396396 3396848 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene2915 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2915 ZOBELLIA_2916 ZOBELLIA_2916 ZOBELLIA_2916 3397047 3397472 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Hypothetical protein gene gene2916 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2916 ZOBELLIA_2917 ZOBELLIA_2917 ZOBELLIA_2917 3397619 3398701 + Membrane fusion protein These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmic membrane by a N-terminal transmembrane region%3B Belongs to the type I secretion system%3B~Family membership gene gene2917 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2917 ZOBELLIA_2918 ZOBELLIA_2918 ZOBELLIA_2918 3398727 3401933 + Multidrug efflux transporter Integral membrane protein involved in drug resistance that belongs to the acrB/acrD/acrF family%3B Contains 12 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2%2C and helices 9 and 10. The three transmembrane domains form a large%2C 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2918 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2918 ZOBELLIA_2919 ZOBELLIA_2919 ZOBELLIA_2919 3401956 3403389 + Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Lipoprotein-type signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene2919 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2919 ZOBELLIA_292 ZOBELLIA_292 ZOBELLIA_292 382713 383309 + Fic family protein This protein belongs to a family including the Fic protein (filamentation induced by cAMP). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate%2C indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. Localized in the cytoplasm.%3B~Family membership gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_292 ZOBELLIA_2920 ZOBELLIA_2920 gnlA gnlA 3403478 3404389 - Gluconolactonase Gluconolactonases hydrolyze the gluconolactone%2C formed either by the glucose oxidoreductase or by the glucose dehydrogenase in aerobic conditions%2C to gluconate%3B Contains a putative lipoprotein signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene2920 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2920 ZOBELLIA_2921 ZOBELLIA_2921 ZOBELLIA_2921 3404392 3405231 - Xylose isomerase-like TIM barrel protein Protein belonging to the Xylose isomerase-like TIM barrel family%3B Contains a twin-arginine translocation pathway signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Family membership gene gene2921 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2921 ZOBELLIA_2922 ZOBELLIA_2922 mazG mazG 3405331 3406113 + Nucleoside triphosphate pyrophosphohydrolase MazG MazG is a nucleoside triphosphate pyrophosphohydrolase which can hydrolyze all eight of the canonical ribo- and deoxynucleoside triphosphates to their respective monophosphates and PP(i)%2C with a preference for deoxynucleotides. MazG also interacts with Era%2C an essential GTPase%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2922 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2922 ZOBELLIA_2923 ZOBELLIA_2923 norM1 norM1 3406195 3407565 + Multidrug resistance protein Multidrug efflux pump that functions probably as a Na(+)/drug antiporter%3B Contains 12 transmembrane segments%3B Belongs to the multi antimicrobial extrusion (MATE) family%2C MdtK subfamily%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2923 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2923 ZOBELLIA_2924 ZOBELLIA_2924 ZOBELLIA_2924 3407567 3407794 + Conserved hypothetical protein Localized in the cytoplasm. gene gene2924 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2924 ZOBELLIA_2925 ZOBELLIA_2925 sepP2 sepP2 3407800 3408381 + Undecaprenyl-diphosphatase Undecaprenyl-diphosphatase catalyzes the hydrolysis of dolichol pyrophosphate%2C likely in connection with glycosylation reactions of membrane%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2925 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2925 ZOBELLIA_2926 ZOBELLIA_2926 ZOBELLIA_2926 3408365 3410020 + Glycosyltransferase%2C family GT83 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 83 of the glycosyltransferases (GT83)%3B Contains eleven transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2926 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2926 ZOBELLIA_2927 ZOBELLIA_2927 arnC2 arnC2 3410035 3410997 - Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase%2C family GT2 ArnC catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the family 2 of the glycosyltransferase (GT2)%3B Contains three C-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2927 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2927 ZOBELLIA_2928 ZOBELLIA_2928 argK argK 3411035 3412078 - LAO/AO transport system kinase ArgK The ArgK protein acts as an ATPase enzyme and as a kinase%2C and phosphorylates periplasmic binding proteins involved in the LAO (lysine%2C arginine%2C ornithine)/AO transport systems. This phosphorylation results in reduced levels of transport activity of the periplasmic transport systems that include each of the binding proteins%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2928 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2928 ZOBELLIA_2929 ZOBELLIA_2929 ZOBELLIA_2929 3412080 3412658 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2929 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2929 ZOBELLIA_293 ZOBELLIA_293 crpA1 crpA1 383481 384113 - Catabolite gene activator This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. It displays a N-terminal cyclic nucleotide-binding domain and a C-terminal helix-turn-helix DNA-binding domain. The cyclic nucleotide-binding domain is composed of three alpha-helices and a distinctive eight-stranded%2C antiparallel beta-barrel structure. There are six invariant amino acids in this domain%2C three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of the beta- barrel. Localized in the cytoplasm.%3B~Specificity unclear gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_293 ZOBELLIA_2930 ZOBELLIA_2930 ohrB ohrB 3412793 3413218 + Organic hydroperoxide resistance protein ohrB OhrB is involved in organic hydroperoxide resistance. It is induced by heat shock%2C salt stress%2C oxidative stress%2C glucose limitation and oxygen limitation. Expression is sigma B-dependent. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene2930 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2930 ZOBELLIA_2931 ZOBELLIA_2931 mroA2 mroA2 3413273 3414178 - Aldose 1-epimerase Aldose 1-epimerase or Mutarotase is responsible for the anomeric interconversion of aldoses between their alpha- and beta-forms%3B It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2931 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2931 ZOBELLIA_2932 ZOBELLIA_2932 msrA3 msrA3 3414378 3415064 - Peptide methionine sulfoxide reductase Peptide methionine sulphoxide reductase MsrA reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide to methionine. MsrA is specific for methionine-S-sulfoxides%3B Thioredoxin acts as a cofactor%3B Contains a prokaryotic lipoprotein signal peptide cleaved between 18 and 19%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene2932 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2932 ZOBELLIA_2933 ZOBELLIA_2933 ZOBELLIA_2933 3415064 3415168 + Putative protein Hypothetical protein gene gene2933 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2933 ZOBELLIA_2934 ZOBELLIA_2934 ZOBELLIA_2934 3415185 3416192 - Conserved hypothetical lipoprotein Protein containing a bacterial Ig-like domain 1 (Big-1). Big-1 domains (~~95 amino acids) are usually present in bacterial adhesion molecules of the intimin/invasin family%2C involved in pathogenicity. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2934 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2934 ZOBELLIA_2935 ZOBELLIA_2935 ZOBELLIA_2935 3416497 3416682 + Putative protein Hypothetical protein gene gene2935 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2935 ZOBELLIA_2936 ZOBELLIA_2936 ZOBELLIA_2936 3416754 3416993 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene2936 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2936 ZOBELLIA_2937 ZOBELLIA_2937 ZOBELLIA_2937 3417454 3417726 - Putative protein Contains a central transmembrane segment%3B Putatively localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2937 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2937 ZOBELLIA_2938 ZOBELLIA_2938 ZOBELLIA_2938 3417948 3419162 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains six N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2938 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2938 ZOBELLIA_2939 ZOBELLIA_2939 ZOBELLIA_2939 3419302 3420696 - NAD(P)-dependent oxidoreductase Conserved NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family. Its exact specificity is unknown%3B Contains a Twin-arginine translocation pathway signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Specificity unclear gene gene2939 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2939 ZOBELLIA_294 ZOBELLIA_294 ZOBELLIA_294 384191 384400 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_294 ZOBELLIA_2940 ZOBELLIA_2940 ZOBELLIA_2940 3420766 3421983 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains six N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2940 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2940 ZOBELLIA_2941 ZOBELLIA_2941 ZOBELLIA_2941 3422220 3423428 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains six N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2941 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2941 ZOBELLIA_2942 ZOBELLIA_2942 secA secA 3423731 3427093 - Preprotein translocase subunit secA SecA is the ATPase subunit of the translocase%2C the preprotein translocation apparatus. SecA has a central role in coupling of the hydrolysis of ATP with the transfer of periplasmic and outer membrane proteins across the cytoplasmic membrane. SecA interacts with the integral membrane subunits secY/secE of the translocase%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2942 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2942 ZOBELLIA_2943 ZOBELLIA_2943 ZOBELLIA_2943 3427122 3427283 + Putative protein Hypothetical protein gene gene2943 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2943 ZOBELLIA_2944 ZOBELLIA_2944 ZOBELLIA_2944 3427289 3427513 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2944 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2944 ZOBELLIA_2945 ZOBELLIA_2945 ZOBELLIA_2945 3427688 3428269 - Cobalamin adenosyltransferase ATP:cob(I)alamin (or ATP:corrinoid) adenosyltransferases catalyse the conversion of cobalamin (vitamin B12) into its coenzyme form%2C adenosylcobalamin (coenzyme B12)%2C or via de novo synthesis. Adenosylcobalamin is required for the ativity of certain enzymes%3B The metabolic pathway where this enzyme is used is unknown%3B Belongs to the Cob(I)alamin adenosyltransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2945 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2945 ZOBELLIA_2946 ZOBELLIA_2946 ZOBELLIA_2946 3428320 3428481 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2946 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2946 ZOBELLIA_2947 ZOBELLIA_2947 ZOBELLIA_2947 3428509 3429033 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2947 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2947 ZOBELLIA_2948 ZOBELLIA_2948 ZOBELLIA_2948 3429078 3430958 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Contains a duplicated ATPase domain%3B Belongs to the ABC transporter family%2C EF3 subfamily%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with a membrane permease component%3B~Family membership gene gene2948 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2948 ZOBELLIA_2949 ZOBELLIA_2949 ZOBELLIA_2949 3430963 3432141 - Conserved hypothetical transmembrane protein Signal peptide cleaved between the residues 22 and 23%3B Contains five transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2949 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2949 ZOBELLIA_295 ZOBELLIA_295 ZOBELLIA_295 384488 384760 - Heavy metal binding protein This protein belongs to the Heavy metal transport protein family. The Heavy-Metal-Associated (HMA) domain contains two conserved cysteines that are probably involved in metal binding. Its structure comprises our- stranded antiparallel beta-sheet and two alpha helices packed in an alpha-beta sandwich fold. Somes of these HMA proteins are involved in bacterial resistance to toxic metals%2C such as lead and cadmium. Localized in the cytoplasm.%3B~Specificity unclear gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_295 ZOBELLIA_2950 ZOBELLIA_2950 pssA pssA 3432245 3432994 + phosphatidylserine synthase This enzyme%2C CDP-diacylglycerol--serine O-phosphatidyltransferase%2C is involved in phospholipid biosynthesis%3B Signal peptide cleaved between the residues 24 and 25%2C Contains six transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2950 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2950 ZOBELLIA_2951 ZOBELLIA_2951 ZOBELLIA_2951 3432991 3433731 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B~Family membership gene gene2951 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2951 ZOBELLIA_2952 ZOBELLIA_2952 tatC tatC 3433822 3434676 - Sec-independent protein translocase Required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif. This system mainly transports proteins with bound cofactors that require folding prior to export%3B Contains six transmembrane segments%3B~High confidence in function and specificity gene gene2952 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2952 ZOBELLIA_2953 ZOBELLIA_2953 kdsD kdsD 3434676 3435641 - Arabinose 5-phosphate isomerase Arabinose 5-phosphate isomerase or Phosphoarabinoisomerase is involved in the lipopolysaccharide (LPS) biosynthesis%3B It catalyzes the interconversion of D-arabinose 5-phosphate and D-ribulose 5-phosphate%3B Contains a N-terminal SIS (Sugar ISomerase) domain that is a phosphosugar-binding domain and a C-terminal CBS (cystathionine-beta-synthase) domans%3B Belongs to the SIS family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2953 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2953 ZOBELLIA_2954 ZOBELLIA_2954 recQ2 recQ2 3435896 3438106 + ATP-dependent DNA helicase RecQ RecQ is a ATP-dependent DNA helicase involved in genome maintenance in the RecF recombination pathway%3B RecQ unwinds paired DNA%2C translocating in a 3' to 5' direction%3B The expression of RecQ gene is under the regulation of the SOS system. Contains a DEAD/H box and a HRDC domain%3B Belongs to superfamily II of helicases%2C RecQ family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2954 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2954 ZOBELLIA_2955 ZOBELLIA_2955 ldcA ldcA 3438184 3439236 - Muramoyltetrapeptide carboxypeptidase%2C family S66 Muramoyltetrapeptide carboxypeptidase converts cytosolic UDP-MurNAc-tetrapeptides to tripeptides%2C the precursors for murein synthesis. Is essential for viability during stationary phase. Belonging to the family S66 of the serine peptidases. The active site is a catalytic triad%2C Ser%2C His Glu. Contains a N-terminal transmembrane segment. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene2955 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2955 ZOBELLIA_2956 ZOBELLIA_2956 ZOBELLIA_2956 3439325 3440662 - Conserved hypothetical protein Contains an N-terminal transmembrane segment followed by a carboxypeptidase domain%3B Localized in the cytoplasmic membrane gene gene2956 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2956 ZOBELLIA_2957 ZOBELLIA_2957 ZOBELLIA_2957 3440756 3440968 + Putative protein Hypothetical protein gene gene2957 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2957 ZOBELLIA_2958 ZOBELLIA_2958 ZOBELLIA_2958 3440965 3441474 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2958 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2958 ZOBELLIA_2959 ZOBELLIA_2959 ZOBELLIA_2959 3441504 3441620 + Putative protein Hypothetical protein gene gene2959 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2959 ZOBELLIA_296 ZOBELLIA_296 glpE2 glpE2 384814 385158 - Thiosulfate sulfurtransferase Thiosulfate sulfurtransferase catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate%3B Contains one only rhodanese domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_296 ZOBELLIA_2960 ZOBELLIA_2960 rluF rluF 3441634 3442362 - Ribosomal large subunit pseudouridine synthase F Enzyme responsible for synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Contains a N-terminal S4 RNA-binding domain that probably mediates binding to RNA.%3B Belongs to the pseudouridine synthase RsuA family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene2960 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2960 ZOBELLIA_2961 ZOBELLIA_2961 ZOBELLIA_2961 3442461 3443684 - Conserved hypothetical protein Contains a C-terminal transmembrane helix%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic membrane gene gene2961 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2961 ZOBELLIA_2962 ZOBELLIA_2962 ZOBELLIA_2962 3443674 3446034 - Conserved hypothetical membrane protein This integral membrane protein encompasses two conserved domains (1-444 and 445-786)%3B Contains 22 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2962 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2962 ZOBELLIA_2963 ZOBELLIA_2963 ZOBELLIA_2963 3446220 3447371 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2963 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2963 ZOBELLIA_2964 ZOBELLIA_2964 ZOBELLIA_2964 3447401 3447652 - Conserved hypothetical protein Localized in the cytoplasm. gene gene2964 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2964 ZOBELLIA_2965 ZOBELLIA_2965 ZOBELLIA_2965 3447771 3447908 + Putative protein Hypothetical protein gene gene2965 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2965 ZOBELLIA_2966 ZOBELLIA_2966 ZOBELLIA_2966 3447851 3448741 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 26 and 27%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene2966 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2966 ZOBELLIA_2967 ZOBELLIA_2967 surA surA 3448725 3450176 + Peptidyl-prolyl isomerase Peptidyl-prolyl isomerase catalyzes the cis-trans isomerization of proline residues. Also known as chaperone%2C SurA is involved in the correct folding and assembly of outer membrane proteins such as ompA%2C ompF and lamB recognizing specific patterns of aromatic residues and the orientation of their side chains. It May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of bacteria in stationary phase%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene2967 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2967 ZOBELLIA_2968 ZOBELLIA_2968 ZOBELLIA_2968 3450181 3451134 + MoxR-like ATPase MoxR-like ATPases have been proposed to function with VWA domain proteins to form a chaperone system involved in the activation of proteins by primarily mediating the insertion of metal cofactors into the substrate molecules%3B Belongs to the MoxR-like family%3B Localized in the cytoplasm%3B~Function unclear gene gene2968 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2968 ZOBELLIA_2969 ZOBELLIA_2969 acnA acnA 3451320 3453587 + Aconitate hydratase Aconitate hydratase is involved in the tricarboxylic acid cycle. It catalyzes the reversible%2C stereo-specific%2C isomerization of citrate to isocitrate via cis-aconitate. It displays a N-terminal catalytic domain which binds a 4Fe-4S cluster and a C-terminal domain which undergoes conformational change in the enzyme mechanism%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2969 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2969 ZOBELLIA_297 ZOBELLIA_297 ZOBELLIA_297 385320 386735 - Metallo-beta-lactamase superfamily protein Conserved protein with a N-terminal domain belonging to the metallo-beta-lactamase superfamily and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue. contains various metallo-hydrolases including beta-lactamases%2C but also glyoxylases and arylsulfatases. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions%3B Localized in the cytoplasm%3B~Function unclear gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_297 ZOBELLIA_2970 ZOBELLIA_2970 ZOBELLIA_2970 3453758 3454213 + Thiol-disulfide oxidoreductase Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Belongs to the thioredoxin family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2970 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2970 ZOBELLIA_2971 ZOBELLIA_2971 ZOBELLIA_2971 3454280 3454780 + Thiol-disulfide oxidoreductase Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Belongs to the thioredoxin family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene2971 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2971 ZOBELLIA_2972 ZOBELLIA_2972 crtZ crtZ 3454784 3455239 - Beta-carotene hydroxylase Carotene hydroxylase%2C involved in the carotenoid biosynthesis%2C catalyzes the hydroxylation of both beta rings of beta-carotene to form zeaxanthine%3B Contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene2972 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2972 ZOBELLIA_2973 ZOBELLIA_2973 crtB crtB 3455241 3456080 - Phytoene synthetase The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate%2C this intermediate is then rearranged to form phytoene%3B Belongs to the phytoene/squalene synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene2973 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2973 ZOBELLIA_2974 ZOBELLIA_2974 crtI crtI 3456092 3457549 - Phytoene dehydrogenase Phytoene dehydrogenase or phytoene desaturase is involved in carotenoid biosynthesis that converts phytoene into zeta-carotene via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene%3B Uses the FAD as cofactor%3B Belongs to the carotenoid/retinoid oxidoreductase family%3B Possible signal peptide of lipoprotein cleaved between thez residues 18 and 19%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene2974 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2974 ZOBELLIA_2975 ZOBELLIA_2975 ZOBELLIA_2975 3457569 3458468 - MerR-type transcriptional regulator The MerR-type transcriptional regulators contain a helix-turn-helix (HTH) DNA-binding motif involved in the binding of the protein to the operator sequences in the DNA. The HTH domain%2C located in the N-terminal part of these proteins%2C is followed by a coiled-coil region. The C-terminal part contains effector binding regions that are specific to the effector recognized%3B Localized in the cytoplasm%3B~Family membership gene gene2975 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2975 ZOBELLIA_2977 ZOBELLIA_2977 ZOBELLIA_2977 3458743 3459048 + Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene2977 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2977 ZOBELLIA_2978 ZOBELLIA_2978 ZOBELLIA_2978 3459069 3459470 + Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator%3B~Family membership gene gene2978 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2978 ZOBELLIA_2979 ZOBELLIA_2979 ZOBELLIA_2979 3459529 3460089 + Heme NO Binding protein The HNOB (Heme NO Binding) module%2C is a predominantly alpha-helical module and binds heme via a covalent linkage to histidine. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands%2C and transduce diverse downstream signals%2C in both bacteria and animals%3B Probably%2C acts as effector domain belonging to a two-component system%3B~Family membership gene gene2979 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2979 ZOBELLIA_298 ZOBELLIA_298 ZOBELLIA_298 386991 387536 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane and/or outer membrane%3B~Hypothetical protein gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_298 ZOBELLIA_2980 ZOBELLIA_2980 ZOBELLIA_2980 3460082 3462073 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains three N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene2980 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2980 ZOBELLIA_2981 ZOBELLIA_2981 ZOBELLIA_2981 3462075 3463208 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene2981 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2981 ZOBELLIA_2982 ZOBELLIA_2982 ZOBELLIA_2982 3463208 3464266 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Possibly localized in the cytoplasm%3B~Family membership gene gene2982 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2982 ZOBELLIA_2983 ZOBELLIA_2983 ZOBELLIA_2983 3464271 3464588 + Histidine-containing phosphotransfer protein The histidine-containing phosphotransfer (HPt) domain is a protein module that mediates phosphotransfer reactions in the two-component signaling systems%3B HPt modules (~~120 residues) contain a histidine residue capable of participating in phosphoryl transfer reactions. They serve as a phosphoreceiver and phosphodonor in order to shuttle phosphoryl groups between two or more response regulator domains.%3B~Family membership gene gene2983 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2983 ZOBELLIA_2984 ZOBELLIA_2984 ZOBELLIA_2984 3464591 3465316 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C which acts as transcriptional regulator%3B~Family membership gene gene2984 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2984 ZOBELLIA_2985 ZOBELLIA_2985 ZOBELLIA_2985 3465709 3467769 - TPR repeats protein Protein containing three tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Function unclear gene gene2985 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2985 ZOBELLIA_2986 ZOBELLIA_2986 ZOBELLIA_2986 3468022 3469551 - Glycoside hydrolase%2C family GH2 Glycoside hydrolases hydrolyze the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. Its exact specificity is unknown%3B Contains a N-terminal transmembrane helix%3B Belongs to the family 2 of the glycoside hydrolases (GH2)%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene2986 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2986 ZOBELLIA_2987 ZOBELLIA_2987 ZOBELLIA_2987 3469548 3470777 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene2987 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2987 ZOBELLIA_2988 ZOBELLIA_2988 ZOBELLIA_2988 3470774 3473860 - Conserved hypothetical membrane protein Contains eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2988 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2988 ZOBELLIA_2989 ZOBELLIA_2989 ZOBELLIA_2989 3474421 3475689 + Conserved hypothetical membrane protein Protein distantly related to the protein Wzx from E. coli which is involved in O-antigen biosynthesis%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2989 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2989 ZOBELLIA_299 ZOBELLIA_299 ZOBELLIA_299 387671 387802 + Putative protein Hypothetical protein gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_299 ZOBELLIA_2990 ZOBELLIA_2990 ZOBELLIA_2990 3475757 3476995 + Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm.%2C Annotation date: 11.12.2006 18:21:50%3B~Specificity unclear gene gene2990 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2990 ZOBELLIA_2991 ZOBELLIA_2991 ZOBELLIA_2991 3477034 3478173 + Dolichol-phosphate mannose synthase%2C family GT2 Modular protein with a N-terminal response regulator receiver domain and a C-terminal dolichol- phosphate mannose synthase. Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The response regulator receiver domain is substrate for a histidine protein kinase sensor. Instead of a transcriptional regulator%2C the C-terminal effector domain is here a dolichol-phosphate mannose synthase. This enzyme belongs to the family 2 of the glycosyltransferase. It catalyses the reaction: GDP-mannose + dolichyl phosphate %3D GDP + dolichyl D-mannosyl phosphate.%3B~High confidence in function and specificity gene gene2991 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2991 ZOBELLIA_2992 ZOBELLIA_2992 ZOBELLIA_2992 3478221 3478889 + TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene2992 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2992 ZOBELLIA_2993 ZOBELLIA_2993 ZOBELLIA_2993 3478957 3479520 + Carboxymuconolactone decarboxylase family protein The exact function of this conserved protein is unknown%3B Belongs to the carboxymuconolactone decarboxylase family%3B Localized in the cytoplasm%3B~Family membership gene gene2993 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2993 ZOBELLIA_2994 ZOBELLIA_2994 ZOBELLIA_2994 3479738 3479842 + Hypothetical protein Domain conserved in some proteins%3B Putatively localized in the cytoplasm gene gene2994 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2994 ZOBELLIA_2995 ZOBELLIA_2995 ZOBELLIA_2995 3479919 3480563 + DSBA thioredoxin family protein The exact function of this DsbA-like protein is unknown%3B Belongs to the Thioredoxin family%2C DSBA subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene2995 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2995 ZOBELLIA_2996 ZOBELLIA_2996 ZOBELLIA_2996 3480896 3482902 + Conserved hypothetical membrane protein Possible enzyme acting with carbohydrates%3B Contains one N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene2996 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2996 ZOBELLIA_2997 ZOBELLIA_2997 ZOBELLIA_2997 3482924 3484183 - Small-conductance mechanosensitive channel family protein The small-conductance mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains five transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene2997 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2997 ZOBELLIA_2998 ZOBELLIA_2998 ZOBELLIA_2998 3484341 3485189 - Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains one N-terminal copy of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene2998 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2998 ZOBELLIA_2999 ZOBELLIA_2999 ZOBELLIA_2999 3485219 3485344 + Putative protein Hypothetical protein gene gene2999 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_2999 ZOBELLIA_3 ZOBELLIA_3 ZOBELLIA_3 2917 3462 + Conserved hypothetical protein Localized in the cytoplasm gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3 ZOBELLIA_30 ZOBELLIA_30 ZOBELLIA_30 31034 31474 - Conserved hypothetical protein Conserved hypothetical protein. Features a signal peptide cleaved between the residues 27 and 28. Localized in the periplasm. gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_30 ZOBELLIA_300 ZOBELLIA_300 tdoA1 tdoA1 387799 388713 - Tryptophan 2%2C3-dioxygenase Tryptophan 2%2C3-dioxygenase is Involved in L-kynurenine metabolism from L-tryptophan%2Cincorporating oxygen into the indole moiety of tryptophan. It has a broad specificity towards tryptamine and derivatives including D-and L-tryptophan%2C 5-hydroxytryptophan and serotonin%3B This enzyme forms a tetramer and binds 2 hemes per subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_300 ZOBELLIA_3000 ZOBELLIA_3000 ZOBELLIA_3000 3485341 3485733 - Conserved hypothetical protein Localized in the cytoplasm gene gene3000 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3000 ZOBELLIA_3001 ZOBELLIA_3001 ZOBELLIA_3001 3486227 3486370 - Putative protein Hypothetical protein gene gene3001 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3001 ZOBELLIA_3002 ZOBELLIA_3002 cda2 cda2 3486411 3488039 - Calcium-dependent ATPase Cda is a calcium-dependent ATPase. Vanadate strongly inhibits its activity%3B Belongs to the alkaline phosphatase clan%2C type I phosphodiesterase family%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3002 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3002 ZOBELLIA_3003 ZOBELLIA_3003 ZOBELLIA_3003 3488376 3489326 - Glycerophosphodiester phosphodiesterase protein family Protein that contains a N-terminal Phosphatidylinositol-specific phospholipase X-box domain%3B Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Signal peptide of lipoprotein cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Family membership gene gene3003 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3003 ZOBELLIA_3004 ZOBELLIA_3004 ZOBELLIA_3004 3489393 3490781 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Probably localized in the outer membrane%3B~Family membership gene gene3004 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3004 ZOBELLIA_3005 ZOBELLIA_3005 ZOBELLIA_3005 3490800 3494243 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a N-terminal carboxypeptidase regulatory domain (117-190)%2C a Plug module (206-316) acting as the channel gate%3B The signal peptide is cleaved between the residue 22 and 23%3B~Family membership gene gene3005 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3005 ZOBELLIA_3006 ZOBELLIA_3006 ZOBELLIA_3006 3494422 3495669 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3006 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3006 ZOBELLIA_3007 ZOBELLIA_3007 ZOBELLIA_3007 3495760 3496389 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3007 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3007 ZOBELLIA_3008 ZOBELLIA_3008 kblA1 kblA1 3496952 3498151 - Glycine C-acetyltransferase Enzyme involved in the Glycine%2C serine and threonine metabolism%2C and in particular%2C in the glycine catabolism%3B Also called 2-amino-3-ketobutyrate coenzyme A ligase%3B Uses the Pyridoxal phosphate as cofactor%3B Belongs to the class II of the pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3008 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3008 ZOBELLIA_3009 ZOBELLIA_3009 ZOBELLIA_3009 3498136 3499110 - NAD-dependent epimerase/dehydratase This enzyme belongs to the NAD-dependent epimerase/dehydratase family%2C which is included in the Rossmann fold Superfamily. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions%3B Localized in the cytoplasm%3B~Family membership gene gene3009 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3009 ZOBELLIA_301 ZOBELLIA_301 ZOBELLIA_301 388717 389154 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_301 ZOBELLIA_3010 ZOBELLIA_3010 ZOBELLIA_3010 3499276 3499737 + AsnC/Lrp-type transcriptional regulator The AsnC/Lrp-type transcriptional regulator family appears to be an important regulatory system of the amino acid metabolism and related processes%3B Contains a N-terminal DNA binding AsnC/Lrp-type HTH domain. The C-terminal part contains an effector-binding domain and/or an oligomerization domain%3B Localized in the cytoplasm%3B~Family membership gene gene3010 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3010 ZOBELLIA_3013 ZOBELLIA_3013 aroK aroK 3500325 3500816 + shikimate kinase Shikimate kinase catalyzes the fifth step in the biosynthesis of aromatic amino acids from chorismate (the shikimate pathway). The enzyme catalyzes the reaction: ATP + shikimate %3D ADP + shikimate-3-phosphate. Shikimate kinaseis found in bacteria%2C plants and fungi%2C but not in metazoans. AroK adopts an alpha/beta fold%2C consisting of a central sheet of five parallel beta-strands flanked by alpha-helices. It binds one magnesium ion. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3013 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3013 ZOBELLIA_3014 ZOBELLIA_3014 pyrR2 pyrR2 3500808 3501305 - Bifunctional protein PyrR PyrR regulates transcriptional attenuation of the pyrimidine nucleotide operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator%2C leading to a reduced expression of downstream genes. Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. Forms momodimer and homohexamer in equilibrium. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3014 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3014 ZOBELLIA_3015 ZOBELLIA_3015 hslR hslR 3501359 3501760 - Heat shock protein 15 HSP15 is involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome%3B Induced by heat shock%3B Contains a S4 RNA-binding domain%3B Belongs to the HSP15 family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3015 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3015 ZOBELLIA_3016 ZOBELLIA_3016 fklA fklA 3501838 3502755 + FKBP-type peptidyl-prolyl cis-trans isomerase Peptidyl-prolyl cis-trans isomerase%2C or PPIase or rotamase%2C accelerates the folding of proteins. It catalyzes the peptidyl-prolyl isomerisation during which the peptide bond preceding proline is stabilised in the cis conformation in oligopeptides%3B Contains a C-terminal calcium binding EF-hand type domain%3B Lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene3016 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3016 ZOBELLIA_3017 ZOBELLIA_3017 ZOBELLIA_3017 3502847 3503440 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3017 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3017 ZOBELLIA_3018 ZOBELLIA_3018 tktB tktB 3503488 3504441 - Transketolase subunit B Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5- phosphate to an aldose receptor%2C such as ribose 5- phosphate%2C to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. TK provides a link between the Embden-Meyerhof and pentose-phosphate (Non-oxidative phase) pathways%3B Uses calcium ion as a cofactor and thiamine diphosphate as prosthetic group%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3018 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3018 ZOBELLIA_3019 ZOBELLIA_3019 tktA tktA 3504503 3505348 - Transketolase subunit A Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5- phosphate to an aldose receptor%2C such as ribose 5- phosphate%2C to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. TK provides a link between the Embden-Meyerhof and pentose-phosphate (Non-oxidative phase) pathways%3B Uses calcium ion as a cofactor and thiamine diphosphate as prosthetic group%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3019 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3019 ZOBELLIA_302 ZOBELLIA_302 ZOBELLIA_302 389151 389540 - Globin-like protein Truncated hemoglobin%3B Localized in the cytoplasm%3B~Family membership gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_302 ZOBELLIA_3020 ZOBELLIA_3020 tgt tgt 3505610 3506770 + Queuine tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr). After this exchange%2C a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine%2C resulting in the hypermodified nucleoside queuosine (Q) (7-(((4%2C5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Binds one Zinc ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3020 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3020 ZOBELLIA_3021 ZOBELLIA_3021 ZOBELLIA_3021 3506770 3507852 + Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3021 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3021 ZOBELLIA_3022 ZOBELLIA_3022 ZOBELLIA_3022 3507873 3508766 + DUF6 family protein Integral membrane protein belonging to the DUF6 family. Features ten transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene3022 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3022 ZOBELLIA_3023 ZOBELLIA_3023 accA accA 3508815 3509768 + Acetyl-coenzyme A carboxylase%2C carboxyl transferase subunit alpha The carboxyl transferase subunit alpha is a part of the Acetyl-coenzyme A carboxylase complex that catalyzes the first step in long-chain fatty acid biosynthesis. the complex is a heterohexamer of biotin carboxyl carrier protein (accB)%2C biotin carboxylase (accC) and two subunits each of carboxyl transferase subunit alpha and subunit beta (accD). First%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3023 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3023 ZOBELLIA_3024 ZOBELLIA_3024 dnaB dnaB 3509924 3511471 + Replicative DNA helicase DnaB is a helicase that interacts with the DnaG primase and other factors to form the replisome. DnaB participates in initiation and elongation during chromosome replication unwinding the DNA duplex at the chromosome replication fork. It exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding%2C DNA binding%2C and interaction with DnaC protein%2C primase%2C and other prepriming proteins%3B Forms a homohexamer%3B Contains a SF4 helicase domain%3B Belongs to the helicase family%2C DnaB subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3024 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3024 ZOBELLIA_3025 ZOBELLIA_3025 ZOBELLIA_3025 3511580 3512845 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3025 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3025 ZOBELLIA_3026 ZOBELLIA_3026 ZOBELLIA_3026 3512889 3515084 - NADPH oxidoreductase Oxidoreductase that contains in its C-terminal%2C a flavodoxin-like domain with a flavin mononucleotide (FMN)-binding site and a NAD-binding domain. In its N-terminal part there are four transmembrane segemnts%3B Belongs to the Flavoprotein pyridine nucleotide cytochrome reductase family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3026 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3026 ZOBELLIA_3027 ZOBELLIA_3027 ZOBELLIA_3027 3515090 3515587 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3027 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3027 ZOBELLIA_3028 ZOBELLIA_3028 ZOBELLIA_3028 3515594 3517099 - Ankyrin repeats protein The ankyrin repeat is involved in protein-protein interaction. The repeats stack together to form an L-shaped structure%3B Contains eleven ankyrin repeats%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Function unclear gene gene3028 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3028 ZOBELLIA_3029 ZOBELLIA_3029 ZOBELLIA_3029 3517188 3518567 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3029 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3029 ZOBELLIA_303 ZOBELLIA_303 ZOBELLIA_303 389628 390170 - Rrf2-type transcriptional regulator The transcriptional regulators with the Rrf2-type HTH domain control a variety of operons that encode iron-sulfur-containing proteins as well as other proteins involved in electron transport. Other rrf2-type HTH proteins are repressors of genes involved in nitrite or iron metabolism. The C-terminal part of the rrf2-type HTH domain contains 3 conserved cysteine residues that may bind an Fe-S cluster. Contains a DNA-binding%2C winged helix-turn-helix (wHTH) domain. Localized in the cytoplasm.%3B~Family membership gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_303 ZOBELLIA_3030 ZOBELLIA_3030 ZOBELLIA_3030 3518588 3521002 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (23-103) and the Plug module (120-225) acting as a channel gate. The signal peptide is cleaved between the residues 17 and 18.%3B~Family membership gene gene3030 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3030 ZOBELLIA_3031 ZOBELLIA_3031 ZOBELLIA_3031 3521128 3522108 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3031 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3031 ZOBELLIA_3032 ZOBELLIA_3032 ZOBELLIA_3032 3522232 3524178 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3032 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3032 ZOBELLIA_3033 ZOBELLIA_3033 ZOBELLIA_3033 3524175 3524579 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3033 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3033 ZOBELLIA_3034 ZOBELLIA_3034 supH supH 3524595 3525401 - Sugar phosphatase SupH Catalyzes%2C in presence of Magnesium%2C the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of fructose-1-P most efficiently%2C but it remains uncertain if this is the real substrate in vivo%3B Belongs to the HAD (Haloacid dehalogenase)-like hydrolase superfamily%2C class II family%2C class IIB subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3034 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3034 ZOBELLIA_3035 ZOBELLIA_3035 yjbQ yjbQ 3525489 3525911 + Conserved hypothetical protein Protein of unknown function%3B Belong to the UPF0047 family%3B Localized in the cytoplasm gene gene3035 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3035 ZOBELLIA_3036 ZOBELLIA_3036 rplT rplT 3525965 3526309 - Ribosomal protein L20 Ribosomal protein L20 is one of the proteins from the large ribosomal subunit (50S). L20 is known to bind directly to the 23S rRNA and is required for ribosome assembly%2C but does not take part in protein synthesis%3B Belongs to the ribosomal protein L20p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3036 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3036 ZOBELLIA_3037 ZOBELLIA_3037 rpmI rpmI 3526398 3526595 - Ribosomal protein L35 L35 is a basic protein from the large subunit (50S) of the ribosome%3B Like many basic polypeptides%2C L35 completely inhibits ornithine decarboxylase when present unbound in the cell%2C but the inhibitory function is abolished upon its incorporation into ribosomes%3B Belongs to the ribosomal protein L35p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3037 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3037 ZOBELLIA_3038 ZOBELLIA_3038 infC infC 3526700 3527161 - Translation initiation factor IF-3 IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit%2C the initiator tRNA and the messenger RNA. IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits%2C thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. IF- 3 is also a translational repressor protein%2C it controls the translation of its own gene by binding to its mRNA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3038 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3038 ZOBELLIA_3039 ZOBELLIA_3039 thrS thrS 3527287 3529233 - Threonyl-tRNA synthetase ThrRS is a homodimeric tRNA synthetase that couples threonine to the 3'OH group of ribose of its cognate tRNA%3B ThrRS controls also the translation of its own gene by binding to its mRNA%3B Contains a C-terminal domain that recognizes the anticodon bases%2C and an N- terminal TGS domain that contributes also to the precise recognition of tRNA(Thr) by interaction with the tRNA acceptor arm along with an adjacent N-terminal domain%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3039 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3039 ZOBELLIA_304 ZOBELLIA_304 cysI cysI 390182 391882 - Sulfite reductase [NADPH] hemoprotein beta-component Sulfite reductase catalyses the six-electron reduction reactions of sulfite to sulfide%3B This is one of several activities required for the biosynthesis of L-cysteine from sulfate%3B The enzyme is a complex composed of two subunits%2C a flavoprotein alpha-component (SiR-FP) and a hemoprotein beta-component (SiR-HP). The quaternary strucure is alpha(8)-beta(4). SiR-HP contains a Fe(4)S(4) cluster coupled to a siroheme through a cysteine bridge%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_304 ZOBELLIA_3040 ZOBELLIA_3040 ZOBELLIA_3040 3529600 3529854 + Hypothetical protein Possibly localized in the cytoplasm gene gene3040 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3040 ZOBELLIA_3046 ZOBELLIA_3046 ZOBELLIA_3046 3535519 3537405 + Hypothetical lipoprotein Contains an N-terminal domain of unknown function DUF 1080%3B Lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3046 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3046 ZOBELLIA_3047 ZOBELLIA_3047 ZOBELLIA_3047 3537418 3539367 + Conserved azurin-containing protein Large conserved protein that Seems to contain an N-terminal transmembrane segment and a C-terminal Blue (type 1) copper domain from the plastocyanin/azurin family%3B Putatively localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3047 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3047 ZOBELLIA_3048 ZOBELLIA_3048 ZOBELLIA_3048 3539403 3540035 + Hemolysin III Hemolysin that could to function as a membrane channel%3B Contains seven transmembrane segments%3B Belongs to the Hly-III family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3048 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3048 ZOBELLIA_3049 ZOBELLIA_3049 ZOBELLIA_3049 3540079 3542310 + Conserved cytochrome c-containing protein Large protein containing a C-terminal cytochrome C domain. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Contains a putative lipoprotein signal peptide cleaved between the residues 19 and 20%3B Possibly localized in the outer membrane%3B~Family membership gene gene3049 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3049 ZOBELLIA_305 ZOBELLIA_305 cysJ cysJ 391924 393744 - Sulfite reductase [NADPH] flavoprotein alpha-component Sulfite reductase catalyses the six-electron reduction reactions of sulfite to sulfide%3B This is one of several activities required for the biosynthesis of L-cysteine from sulfate%3B The enzyme is a complex composed of two subunits%2C a flavoprotein alpha-component (SiR-FP) and a hemoprotein beta-component (SiR-HP). The quaternary strucure is alpha(8)-beta(4)%3B The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component%3B Binds one FAD and ond FMN per subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_305 ZOBELLIA_3050 ZOBELLIA_3050 ZOBELLIA_3050 3542315 3543130 - Hypothetical protein It is not clear if this protein of unknown function is a lipoprotein localized in the outer membrane or protein exported in the pepriplasmic space gene gene3050 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3050 ZOBELLIA_3051 ZOBELLIA_3051 ZOBELLIA_3051 3543165 3543515 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene3051 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3051 ZOBELLIA_3052 ZOBELLIA_3052 ZOBELLIA_3052 3543612 3544001 + Conserved hypothetical protein Sequence that is found in the conserved part of the barrel structure of a TonB-dependent receptor%3B Putatively localized in the cytoplasm gene gene3052 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3052 ZOBELLIA_3053 ZOBELLIA_3053 ZOBELLIA_3053 3544335 3545720 - Hypothetical protein Probably localized in the cytoplasm gene gene3053 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3053 ZOBELLIA_3054 ZOBELLIA_3054 ZOBELLIA_3054 3546111 3546356 + Putative membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3054 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3054 ZOBELLIA_3055 ZOBELLIA_3055 ZOBELLIA_3055 3546808 3547320 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3055 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3055 ZOBELLIA_3056 ZOBELLIA_3056 ZOBELLIA_3056 3547856 3548536 + Hypothetical protein Probably localized in the cytoplasm gene gene3056 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3056 ZOBELLIA_3057 ZOBELLIA_3057 ZOBELLIA_3057 3548598 3550499 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains seven N-terminal tetratrico peptide repeats (TPR) and two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3057 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3057 ZOBELLIA_3058 ZOBELLIA_3058 ZOBELLIA_3058 3550496 3550933 - Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene3058 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3058 ZOBELLIA_3059 ZOBELLIA_3059 ZOBELLIA_3059 3551164 3551826 - Two-component system-Response regulator Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA- binding activity (here%2C a LuxR-type HTH domain) that acts as transcriptional regulator%3B~Family membership gene gene3059 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3059 ZOBELLIA_306 ZOBELLIA_306 ZOBELLIA_306 393764 394399 - Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~Specificity unclear gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_306 ZOBELLIA_3060 ZOBELLIA_3060 ZOBELLIA_3060 3551918 3552127 - Transposase (pseudogene)%2C family 8 Sequence representing the C-terminal part of transposase that could be an insertion sequence (IS). The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Contains a integrase catalytic domain%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3060 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3060 ZOBELLIA_3061 ZOBELLIA_3061 ZOBELLIA_3061 3552088 3552339 - Transposase (pseudogene)%2C family 8 Sequence representing the central part of transposase. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site- specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3061 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3061 ZOBELLIA_3062 ZOBELLIA_3062 ZOBELLIA_3062 3552341 3552493 - Transposase (pseudogene)%2C family 8 Sequence representing the central part of transposase. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site- specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3062 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3062 ZOBELLIA_3063 ZOBELLIA_3063 ZOBELLIA_3063 3552763 3553059 - Transposase (pseudogene)%2C family 8 Sequence representing the N-terminal part of transposase that could be an insertion sequence (IS). The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Contains a integrase catalytic domain%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3063 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3063 ZOBELLIA_3064 ZOBELLIA_3064 ZOBELLIA_3064 3553451 3556945 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (50-101)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (106-180) and a Plug module (197-327) acting as the channel gate%3B The signal peptide is cleaved between the residue 22 and 23%3B~Family membership gene gene3064 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3064 ZOBELLIA_3065 ZOBELLIA_3065 ZOBELLIA_3065 3556950 3558446 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Probably localized in the outer membrane%3B~Family membership gene gene3065 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3065 ZOBELLIA_3066 ZOBELLIA_3066 ZOBELLIA_3066 3558508 3559830 + Chitin-binding lectin%2C family GH18 This protein is homologous to chitinases but the catalytic acidic residues are replaced by polar residues. It likely binds chitin or chitin-derived oligosaccharides%3B Belongs to the family 18 of the glycoside hydrolases (GH18)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Function unclear gene gene3066 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3066 ZOBELLIA_3067 ZOBELLIA_3067 ZOBELLIA_3067 3560113 3560433 + Hypothetical protein Protein that corresponds to a fragment of receveir domains present in the response regulators of the LytR/AlgR family%3B Putatively localized in the cytoplasm gene gene3067 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3067 ZOBELLIA_3068 ZOBELLIA_3068 ZOBELLIA_3068 3561435 3562847 + Hypothetical protein Contains a N-terminal J domain present in the DnaJ protein%3B Localized in the cytoplasm gene gene3068 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3068 ZOBELLIA_3069 ZOBELLIA_3069 ZOBELLIA_3069 3563264 3563380 - Transposase (fragment) The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Localized in the cytoplasm%3B~Hypothetical protein gene gene3069 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3069 ZOBELLIA_307 ZOBELLIA_307 ZOBELLIA_307 394632 395525 - LysR-type transcriptional regulator Transcriptional regulator belonging to the LysR family. Features a N-terminal helix-turn-helix DNA binding domain and a C-terminal LysR-like substrate binding domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_307 ZOBELLIA_3070 ZOBELLIA_3070 ZOBELLIA_3070 3563400 3563609 + Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3070 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3070 ZOBELLIA_3071 ZOBELLIA_3071 ZOBELLIA_3071 3563647 3564486 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene3071 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3071 ZOBELLIA_3072 ZOBELLIA_3072 ZOBELLIA_3072 3564850 3564957 + Putative protein Hypothetical protein gene gene3072 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3072 ZOBELLIA_3073 ZOBELLIA_3073 ZOBELLIA_3073 3565010 3565423 - Hypothetical protein Localized in the cytoplasm gene gene3073 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3073 ZOBELLIA_3074 ZOBELLIA_3074 ZOBELLIA_3074 3565735 3567234 + Hypothetical protein Localized in the cytoplasm gene gene3074 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3074 ZOBELLIA_3075 ZOBELLIA_3075 ZOBELLIA_3075 3567517 3567657 + Putative protein Hypothetical protein gene gene3075 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3075 ZOBELLIA_3076 ZOBELLIA_3076 ZOBELLIA_3076 3567738 3568199 - Transposase (pseudogene)%2C family 8 Protein that is the C-terminal part of a transposases that consists to an integrase domain. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3076 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3076 ZOBELLIA_3077 ZOBELLIA_3077 ZOBELLIA_3077 3568531 3568656 - Transposase (pseudogene)%2C family 8 Protein that is the N-terminal part of a transposases. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3077 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3077 ZOBELLIA_3078 ZOBELLIA_3078 ZOBELLIA_3078 3568758 3569387 - Hypothetical protein Probably localized in the cytoplasm gene gene3078 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3078 ZOBELLIA_3079 ZOBELLIA_3079 ZOBELLIA_3079 3569728 3569985 - ATPase (pseudogene) Probable fragment of protein that binds ATP%3B Seems to belong to the ATPase P-loop family%3B~Hypothetical protein gene gene3079 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3079 ZOBELLIA_308 ZOBELLIA_308 scdA scdA 396109 396843 + Cell wall-related protein ScdA Involved in peptidoglycan cross-linking. Required for normal cell growth and development. Contains two Hemerythrin HHE cation binding domains.%3B~Family membership gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_308 ZOBELLIA_3080 ZOBELLIA_3080 ZOBELLIA_3080 3570257 3570679 - Conserved hypothetical protein Putatively localized in the cytoplasmic membrane via a transmembrane segment gene gene3080 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3080 ZOBELLIA_3081 ZOBELLIA_3081 ZOBELLIA_3081 3572175 3572420 - Putative protein Hypothetical protein gene gene3081 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3081 ZOBELLIA_3082 ZOBELLIA_3082 ZOBELLIA_3082 3572626 3574554 + OmpA-like periplasmic protein This protein has a modular architecture composed of a N-terminal TPR motif%2C a central beta-propeller domain%2C encompassing four WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan. The tetratrico peptide repeat (TPR) is a structural motif%2C which mediates proteinprotein interactions%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space and/or in the outer membrane%3B~Family membership gene gene3082 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3082 ZOBELLIA_3083 ZOBELLIA_3083 ZOBELLIA_3083 3574771 3575583 + Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3083 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3083 ZOBELLIA_3084 ZOBELLIA_3084 ZOBELLIA_3084 3575749 3576039 + Hypothetical protein Probably localized in the cytoplasm gene gene3084 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3084 ZOBELLIA_3085 ZOBELLIA_3085 ZOBELLIA_3085 3576185 3577090 + Hypothetical protein Putatively localized in the cytoplasm. gene gene3085 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3085 ZOBELLIA_3086 ZOBELLIA_3086 ZOBELLIA_3086 3577578 3579212 + FMN / Fe-S cluster binding protein Protein containing a N-terminal Rieske [2Fe-2S] domain and a C-terminal domain Localized in the cytoplasm.%3B~Function unclear gene gene3086 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3086 ZOBELLIA_3087 ZOBELLIA_3087 ZOBELLIA_3087 3579307 3580005 - Transposase (pseudogene)%2C Mutator family This protein corresponds to the C-terminal region of a transposase and is likely inactive%3B The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the transposase mutator family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3087 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3087 ZOBELLIA_3088 ZOBELLIA_3088 ZOBELLIA_3088 3580094 3580492 - Transposase (pseudogene)%2C Mutator family Protein that corresponds to the N-terminal region of a transposase%3B The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the transposase mutator family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3088 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3088 ZOBELLIA_3089 ZOBELLIA_3089 ZOBELLIA_3089 3580591 3582663 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3089 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3089 ZOBELLIA_309 ZOBELLIA_309 ZOBELLIA_309 396833 397393 + Hypothetical protein Putatively localized in the cytoplasm. gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_309 ZOBELLIA_3090 ZOBELLIA_3090 ZOBELLIA_3090 3582691 3582906 - Conserved hypothetical protein Protein fragment found in various UDP-N-acetylmuramyl pentapeptide synthases%3B Contains an N-terminal UDP-N-acetylmuramyl pentapeptide synthases domain%3B Putatively localized in the cytoplasm gene gene3090 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3090 ZOBELLIA_3091 ZOBELLIA_3091 murF2 murF2 3582888 3583409 - UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase%2C catalytic domain UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF) is an enzyme involved in the final step of the biosynthesis of peptidoglycan which catalyzes the addition of D-alanyl-D-alanine to the nucleotide precursor UDP-N- acetylmuramoyl-L-alanyl-D-glutamyl-meso-2%2C6-diaminoheptanedioate%3B Belongs to the MurCDEF family%3B This sequence is the N-terminal catalytic domain of MurF only%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3091 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3091 ZOBELLIA_3092 ZOBELLIA_3092 ZOBELLIA_3092 3583387 3583482 - Putative protein Hypothetical protein gene gene3092 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3092 ZOBELLIA_3093 ZOBELLIA_3093 traK traK 3583466 3584074 - Conjugative transposon protein TraK TraK is part of a conjugative transposon and is predicted to be involved in its transfer%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane.%3B~Function unclear gene gene3093 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3093 ZOBELLIA_3094 ZOBELLIA_3094 ZOBELLIA_3094 3584136 3584384 - Putative protein Hypothetical protein gene gene3094 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3094 ZOBELLIA_3095 ZOBELLIA_3095 ZOBELLIA_3095 3584403 3584696 - Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3095 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3095 ZOBELLIA_3096 ZOBELLIA_3096 ZOBELLIA_3096 3584708 3584986 - Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3096 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3096 ZOBELLIA_3097 ZOBELLIA_3097 ZOBELLIA_3097 3585304 3585651 - Transposase (fragment)%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Putatively localized in the cytoplasm%3B~Hypothetical protein gene gene3097 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3097 ZOBELLIA_3098 ZOBELLIA_3098 mobC mobC 3586009 3588015 + Putative mobilization protein MobC MobC is part of the conjugative transposon CTn341%2C first identified in Bacteroides strains. It is involved in the transfer and mobilization of CTn341%3B Belongs to the TraG/TraD family%3B Contain a P-loop and walker-B site for nucleotide binding and five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3098 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3098 ZOBELLIA_3099 ZOBELLIA_3099 ZOBELLIA_3099 3588151 3588705 + Metallopeptidase%2C family M23 Peptidase family M23 mainly contains endopeptidases that hydrolyze bacterial cell wall peptidoglycans. One catalytic zinc ion is bound per peptidase molecule. The cation ligands occur in the conserved motifs HXXXD and HXH. The first histidine of the second motif is also involved in the catalysis%3B Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3099 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3099 ZOBELLIA_31 ZOBELLIA_31 rbnA rbnA 31471 32439 - Ribonuclease BN The ribonuclease BN is a 3' to 5' exoribonuclease necessary for 3' maturation of some tRNA molecules%3B The substrate specificity of RNase BN appears to be very narrow and its biological role is uncertain. Contains six transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_31 ZOBELLIA_310 ZOBELLIA_310 ZOBELLIA_310 397491 398009 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_310 ZOBELLIA_3100 ZOBELLIA_3100 ZOBELLIA_3100 3588732 3588938 + Putative protein Hypothetical protein gene gene3100 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3100 ZOBELLIA_3101 ZOBELLIA_3101 traM traM 3588942 3589964 + Conjugative transposon protein TraM TraM is part of a conjugative transposon and is predicted to be involved in its transfer%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3101 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3101 ZOBELLIA_3102 ZOBELLIA_3102 traG traG 3589954 3592293 + Conjugative transposon protein TraG TraG is part of the conjugative transposon and likely involved in its transfer%3B Localized in the cytoplasm%3B~Function unclear gene gene3102 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3102 ZOBELLIA_3103 ZOBELLIA_3103 traN traN 3592302 3593135 + Conjugative transposon protein TraN TraN is part of the conjugative transposon and likely involved in its transfer%3B Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Function unclear gene gene3103 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3103 ZOBELLIA_3104 ZOBELLIA_3104 ZOBELLIA_3104 3593241 3593735 + Hypothetical protein Localized in the cytoplasm gene gene3104 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3104 ZOBELLIA_3105 ZOBELLIA_3105 ZOBELLIA_3105 3593766 3594077 + Hypothetical protein Localized in the cytoplasm gene gene3105 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3105 ZOBELLIA_3106 ZOBELLIA_3106 ZOBELLIA_3106 3594084 3594590 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3106 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3106 ZOBELLIA_3107 ZOBELLIA_3107 ZOBELLIA_3107 3594838 3595446 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3107 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3107 ZOBELLIA_3108 ZOBELLIA_3108 ZOBELLIA_3108 3595514 3596071 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3108 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3108 ZOBELLIA_3109 ZOBELLIA_3109 ZOBELLIA_3109 3596095 3596622 + Hypothetical protein Localized in the cytoplasm gene gene3109 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3109 ZOBELLIA_311 ZOBELLIA_311 ZOBELLIA_311 398070 399887 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasm%3B~Hypothetical protein gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_311 ZOBELLIA_3110 ZOBELLIA_3110 ZOBELLIA_3110 3596633 3597184 + Hypothetical protein Localized in the cytoplasm gene gene3110 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3110 ZOBELLIA_3111 ZOBELLIA_3111 traJ traJ 3597190 3598065 + Conjugative transposon proteinTraJ TraJ is part of a conjugative transposon and is predicted to be involved in its transfer. Contains six transmembrane helices. Localized in the cytoplasmic membrane.%3B~Function unclear gene gene3111 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3111 ZOBELLIA_3112 ZOBELLIA_3112 ZOBELLIA_3112 3598600 3600138 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Contains one transmembrane segment%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3112 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3112 ZOBELLIA_3113 ZOBELLIA_3113 ZOBELLIA_3113 3600351 3601139 - Transposase (pseudogene)%2C family 8 Protein representing the C-terminal part of transposase that could be an insertion sequence (IS). The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Contains a integrase catalytic domain%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3113 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3113 ZOBELLIA_3114 ZOBELLIA_3114 ZOBELLIA_3114 3601201 3601479 - Transposase (pseudogene)%2C family 8 Protein representing the N-terminal part of transposase that could be an insertion sequence (IS). The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3114 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3114 ZOBELLIA_3115 ZOBELLIA_3115 ZOBELLIA_3115 3601930 3602022 + Putative protein Hypothetical protein gene gene3115 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3115 ZOBELLIA_3116 ZOBELLIA_3116 ZOBELLIA_3116 3602230 3602331 + Putative protein Hypothetical protein gene gene3116 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3116 ZOBELLIA_3117 ZOBELLIA_3117 ZOBELLIA_3117 3602613 3603527 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3117 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3117 ZOBELLIA_3118 ZOBELLIA_3118 ZOBELLIA_3118 3603543 3604559 - LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene3118 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3118 ZOBELLIA_3119 ZOBELLIA_3119 ZOBELLIA_3119 3604808 3607939 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (34-108) and the Plug module (124-231) acting as a channel gate%3B The signal peptide is cleaved between the residues 30 and 31%3B~Family membership gene gene3119 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3119 ZOBELLIA_312 ZOBELLIA_312 ZOBELLIA_312 399989 401641 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_312 ZOBELLIA_3120 ZOBELLIA_3120 ZOBELLIA_3120 3607959 3609815 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 25 and 26%3B Putatively localized in the outer membrane%3B~Family membership gene gene3120 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3120 ZOBELLIA_3121 ZOBELLIA_3121 ZOBELLIA_3121 3609935 3611128 + Hypothetical protein Probably localized in the cytoplasm gene gene3121 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3121 ZOBELLIA_3122 ZOBELLIA_3122 ZOBELLIA_3122 3611146 3612522 + NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase that belongs to the Rossmann fold family%3B Contains a twin-arginine translocation signal peptide%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3122 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3122 ZOBELLIA_3123 ZOBELLIA_3123 ZOBELLIA_3123 3612644 3614023 + Conserved hypothetical lipoprotein Contains a signal peptide of lipoprotein cleaved between the residues 15 and 16%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene3123 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3123 ZOBELLIA_3124 ZOBELLIA_3124 ZOBELLIA_3124 3614026 3614844 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B Localized in the cytoplasm%3B~Family membership gene gene3124 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3124 ZOBELLIA_3125 ZOBELLIA_3125 uxuA1 uxuA1 3614846 3616045 + Mannonate dehydratase Mannonate dehydratase%2C induced By fructuronate%2C is a Fe2+-requiring enzyme that plays a role in D-glucuronate catabolism%3B Mannonate dehydratase converts D-mannonate to 2-dehydro-3-deoxy-D-gluconate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3125 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3125 ZOBELLIA_3126 ZOBELLIA_3126 ZOBELLIA_3126 3616048 3616476 - Conserved hypothetical protein Localized in the cytoplasm gene gene3126 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3126 ZOBELLIA_3127 ZOBELLIA_3127 ZOBELLIA_3127 3616478 3617149 - Metal ion transporter This protein is a permease possibly responsible for zinc uptake%3B Belongs to the ZIP (zinc transporter proteins) family%3B Contains seven transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3127 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3127 ZOBELLIA_3128 ZOBELLIA_3128 ZOBELLIA_3128 3617373 3618527 + Possible RNA methylase Protein of unknown function that contains a N-terminal THUMP (thiouridine synthases%2C RNA methylases and pseudouridine) domain involved in RNA metabolism with a predicted RNA-binding capacity. Also contains a C-terminal Methylase domain%3B Belongs to the UPF0020 family%3B Localized in the cytoplasm%3B~Function unclear gene gene3128 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3128 ZOBELLIA_3129 ZOBELLIA_3129 ZOBELLIA_3129 3618555 3619382 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3129 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3129 ZOBELLIA_313 ZOBELLIA_313 ZOBELLIA_313 401653 404790 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (85-159)%2C and a Plug module (175-281) acting as the channel gate%3B The signal peptide is cleaved between the residue 32 and 33%3B~Family membership gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_313 ZOBELLIA_3130 ZOBELLIA_3130 ZOBELLIA_3130 3619363 3619851 - Conserved hypothetical lipoprotein Could be a lipoprotein with a signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Conserved hypothetical protein gene gene3130 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3130 ZOBELLIA_3131 ZOBELLIA_3131 rumA rumA 3619856 3621292 - 23S rRNA (uracil-5-)-methyltransferase RumA The RumA protein catalyzes the formation of 5-methyl-uridine at position 1939 (M-5-U1939) in 23S rRNA%3B Contains two structural domains: an N-terminal TRAM domain predicted to bind RNA and deliver the RNA-modifying enzymatic domain to their targets%2C and a C-terminal tRNA (Uracil-5-)-methyltransferase domain that displays the typical SAM-dependent methyltransferase fold%3B Belongs to the RNA M5U methyltransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3131 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3131 ZOBELLIA_3132 ZOBELLIA_3132 rocD rocD 3621604 3622848 + Ornithine aminotransferase Ornithine aminotransferase is involved in the Urea cycle and it is responsible for the fourth step in arginine biosynthesis. It catalyzes the transfer of an amino group from ornithine to a 2-oxo acid%2C yielding glutamic-5-semi-aldehyde and an L-amino acid%3B Uses the Pyridoxal phosphate as cofactor linked to a conserved lysine residue%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3132 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3132 ZOBELLIA_3133 ZOBELLIA_3133 ZOBELLIA_3133 3622902 3623213 - Conserved hypothetical membrane protein Contains an N-terminal and a C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3133 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3133 ZOBELLIA_3134 ZOBELLIA_3134 ZOBELLIA_3134 3623217 3623546 - Conserved hypothetical membrane protein Contains an N-terminal and a C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3134 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3134 ZOBELLIA_3135 ZOBELLIA_3135 ZOBELLIA_3135 3623550 3623861 - Conserved hypothetical membrane protein Contains two C-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3135 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3135 ZOBELLIA_3136 ZOBELLIA_3136 ZOBELLIA_3136 3623924 3624469 + Smr protein Small protein that contain a C-terminal Smr (Small MutS Related) domain%3B The Smr domain would act as a nicking endonuclease and would interact with the MutS-1 protein%3B Belongs to the DNA mismatch repair mutS family%3B Localized in the cytoplasm%3B~Function unclear gene gene3136 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3136 ZOBELLIA_3137 ZOBELLIA_3137 ZOBELLIA_3137 3624466 3625479 - Conserved hypothetical lipoprotein Liporptein with a signal peptide cleaved between the residues 15 and 16%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3137 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3137 ZOBELLIA_3138 ZOBELLIA_3138 iscS iscS 3625582 3626730 + Cysteine desulfurase Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine%2C an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules as thio-nucleosides in tRNA%2C thiamine%2C biotin%2C lipoate%2C molybdopterin and Fe-S cluster%3B Uses the Pyridoxal phosphate as prosthetic group linked to a lysine residue%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3138 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3138 ZOBELLIA_3139 ZOBELLIA_3139 ZOBELLIA_3139 3626762 3627415 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3139 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3139 ZOBELLIA_314 ZOBELLIA_314 ZOBELLIA_314 405203 407101 - Alpha-glucosidase%2C family GH97 Alpha-glucosidases catalyse the hydrolysis of terminal%2C non-reducing 1%2C4-linked alpha-D-glucose residues with release of alpha-D-glucose. Involved in carbohydrate metabolism%2C notably in starch degradation%3B Belongs to the family 97 of glycoside hydrolases (GH97)%3B Lipoprotein signal peptide cleaved between the residues 20 and 21%3B localized in the outer membrane%3B~High confidence in function and specificity gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_314 ZOBELLIA_3140 ZOBELLIA_3140 ZOBELLIA_3140 3627427 3629895 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (24-102) and the Plug module (143-223) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~High confidence in function and specificity gene gene3140 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3140 ZOBELLIA_3141 ZOBELLIA_3141 ZOBELLIA_3141 3629903 3631594 - Metallopeptidase%2C family M23 Peptidase family M23 mainly contains endopeptidases that lyze bacterial cell wall peptidoglycans. One catalytic zinc ion is bound per peptidase molecule. The cation ligands occur in the conserved motifs HXXXD and HXH. The first histidine of the second motif is also involved in the catalysis. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm.%3B~Specificity unclear gene gene3141 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3141 ZOBELLIA_3142 ZOBELLIA_3142 ZOBELLIA_3142 3631788 3632078 + Conserved hypothetical protein Localized in cytoplasm gene gene3142 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3142 ZOBELLIA_3143 ZOBELLIA_3143 ZOBELLIA_3143 3632094 3632390 + Conserved hypothetical protein Localized in the cytoplasm gene gene3143 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3143 ZOBELLIA_3144 ZOBELLIA_3144 ZOBELLIA_3144 3632682 3634250 + Metal-dependent phosphohydrolase Possible metal-dependent phosphohydrolase that could act to RNA molecules%3B Contains an N-terminal transmembrane segment and%2C in the C-terminal part%2C one KH domain and an HD domain%3B The KH domain binds RNA%2C and can function in RNA recognition%3B Belongs to the UPF0144 family%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3144 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3144 ZOBELLIA_3145 ZOBELLIA_3145 ZOBELLIA_3145 3634325 3635860 - Sulfatase%2C family S1-19 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 19%3B Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3145 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3145 ZOBELLIA_3146 ZOBELLIA_3146 idsA3 idsA3 3635860 3637494 - Iduronate-2-sulfatase%2C family S1-7 Iduronate-2-sulfatase%2C called also chondroitinsulfatase is involved in the glycosaminoglycan degradation. It hydrolyzes the 2-sulfate groups from non-reducing-terminal iduronic acid residues in dermatan sulfate%2C heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 7%3B Lipoprotein with a signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene3146 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3146 ZOBELLIA_3147 ZOBELLIA_3147 ZOBELLIA_3147 3637536 3639581 - Conserved hypothetical periplasmic protein Conserved protein belonging to the DUF1680 family protein%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3147 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3147 ZOBELLIA_3148 ZOBELLIA_3148 ZOBELLIA_3148 3639763 3641733 - Conserved hypothetical protein Conserved protein belonging to the DUF1680 family protein%3B Localized in the cytoplasm gene gene3148 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3148 ZOBELLIA_3149 ZOBELLIA_3149 ZOBELLIA_3149 3641770 3643350 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3149 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3149 ZOBELLIA_315 ZOBELLIA_315 ZOBELLIA_315 407167 407721 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_315 ZOBELLIA_3150 ZOBELLIA_3150 ZOBELLIA_3150 3643390 3645474 - Conserved hypothetical membrane protein Protein containing a domain of unknown function DUF1680 predicted to be a possible new family of glycoside hydrolases of unknown specificity%3B Putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Family membership gene gene3150 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3150 ZOBELLIA_3151 ZOBELLIA_3151 ZOBELLIA_3151 3645790 3647580 - Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3151 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3151 ZOBELLIA_3152 ZOBELLIA_3152 ZOBELLIA_3152 3647622 3649703 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3152 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3152 ZOBELLIA_3153 ZOBELLIA_3153 dgoA dgoA 3649765 3650412 - 2-Dehydro-3-deoxy-6-phosphogalactonate aldolase 2-Dehydro-3-deoxy-6-phosphogalactonate aldolase catalyzes the third step of the D-galactonate catabolism: 2-dehydro-3-deoxy-D-galactonate 6-phosphate %3D pyruvate + D-glyceraldehyde 3-phosphate. Belongs to the class I aldolase whose catalytic mechanism involves the formation of a Schiff-base intermediate between the substrate and the epsilon-amino group of a lysine residue. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3153 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3153 ZOBELLIA_3154 ZOBELLIA_3154 dgoK dgoK 3650402 3651355 - 2-Dehydro-3-deoxygalactonokinase 2-Dehydro-3-deoxygalactonokinase catalyzes the second step in D-galactonate degradation: ATP + 2-dehydro-3-deoxy-D-galactonate %3D ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3154 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3154 ZOBELLIA_3155 ZOBELLIA_3155 aldA aldA 3651352 3652803 - Lactaldehyde dehydrogenase Lactaldehyde dehydrogenase catalyze the NAD-dependent oxidation of lactaldehyde into lactate. This protein is a tetramer. AldA is involved in the catabolism of L-fucose and L-rhamnose and is induced by these sugars. In aerobic condition%2C the lactaldehyde is produced by the cleavage of L-fucose or L-rhamnose%3B Belongs to the aldehyde dehydrogenase fold family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3155 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3155 ZOBELLIA_3156 ZOBELLIA_3156 dgoD dgoD 3652778 3653944 - Galactonate dehydratase Galactonate dehydratase catalyzes the first step of the D-galactonate catabolism converting the D-galactonate to 2-dehydro-3-deoxy-D-galactonate%3B Contains a N-terminal Enolase-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase/muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3156 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3156 ZOBELLIA_3157 ZOBELLIA_3157 rhaT1 rhaT1 3653980 3654987 - L-rhamnose/proton symporter L-rhamnose/proton symporter is involved in the uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell. Can also transport L-mannose and L-xylose%2C but at reduced rates. Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3157 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3157 ZOBELLIA_3158 ZOBELLIA_3158 gntT3 gntT3 3655123 3656424 - High-affinity gluconate transporter GntT is part of the gluconate utilization system Gnt-I. It is a permease responsible for high-affinity intake of gluconate%3B Contains twelve transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3158 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3158 ZOBELLIA_3159 ZOBELLIA_3159 ZOBELLIA_3159 3656545 3657429 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3159 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3159 ZOBELLIA_316 ZOBELLIA_316 ZOBELLIA_316 407766 409649 - Alpha-glucosidase%2C family GH97 Alpha-glucosidases catalyse the hydrolysis of terminal%2C non-reducing 1%2C4-linked alpha-D-glucose residues with release of alpha-D-glucose. Involved in carbohydrate metabolism%2C notably in starch degradation%3B Belongs to the family 97 of glycoside hydrolases (GH97)%3B Lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the cytoplasmic or outer membrane or both%3B~High confidence in function and specificity gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_316 ZOBELLIA_3160 ZOBELLIA_3160 lldD1 lldD1 3657707 3658861 - L-lactate dehydrogenase [cytochrome] L-lactate dehydrogenase is involved in L-lactate degradation converting the L-lactate to pyruvate%3B Uses flavin mononucleotide (FMN) as prosthetic group%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3160 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3160 ZOBELLIA_3161 ZOBELLIA_3161 ZOBELLIA_3161 3658871 3660298 - Carbohydrate kinase Carbohydrate kinase belonging to the FGGY family. Its exact specificity is unknown%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3161 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3161 ZOBELLIA_3162 ZOBELLIA_3162 ZOBELLIA_3162 3660282 3662387 - Conserved hypothetical oxydoreductase Contains an hypothetical N-terminal aldolase II domain and a C-terminal domain belonging to the short chain dehydrogenase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3162 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3162 ZOBELLIA_3163 ZOBELLIA_3163 ZOBELLIA_3163 3662580 3663626 + GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA. At the C-terminus there is an effector- binding/oligomerisation domain%3B Localized in the cytoplasm%3B~Family membership gene gene3163 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3163 ZOBELLIA_3164 ZOBELLIA_3164 ZOBELLIA_3164 3663846 3666536 + Cytochrome c-containing lipoprotein Large conserved protein containing a C-terminal cytochrome C. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3164 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3164 ZOBELLIA_3165 ZOBELLIA_3165 ZOBELLIA_3165 3666578 3667444 + Conserved hypothetical membrane protein Conserved protein belonging to the DUF1080 family%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3165 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3165 ZOBELLIA_3166 ZOBELLIA_3166 ZOBELLIA_3166 3667471 3668541 + Conserved hypothetical protein Localized in the cytoplasm gene gene3166 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3166 ZOBELLIA_3167 ZOBELLIA_3167 ZOBELLIA_3167 3668559 3669770 + Conserved hypothetical protein Localized in the cytoplasm gene gene3167 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3167 ZOBELLIA_3168 ZOBELLIA_3168 ZOBELLIA_3168 3669865 3670893 + Conserved hypothetical protein Localized in the cytoplasm gene gene3168 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3168 ZOBELLIA_3169 ZOBELLIA_3169 ZOBELLIA_3169 3670914 3671723 + Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene3169 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3169 ZOBELLIA_317 ZOBELLIA_317 ZOBELLIA_317 409698 410486 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_317 ZOBELLIA_3170 ZOBELLIA_3170 ZOBELLIA_3170 3671809 3672621 + Xylose isomerase-like TIM barrel protein Conserved protein belonging to the Xylose isomerase-like TIM barrel family%3B Localized in the cytoplasm%3B~Family membership gene gene3170 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3170 ZOBELLIA_3171 ZOBELLIA_3171 ZOBELLIA_3171 3672656 3673807 + NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family%3B Adopts a Rossmann fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3171 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3171 ZOBELLIA_3172 ZOBELLIA_3172 fclA fclA 3673904 3674989 - GDP-L-fucose synthetase GDP-L-fucose synthetase is involved in EPS biosynthesis. It catalyzes the two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose%2C involving an epimerase and a reductase reaction%3B Forms a homodimer%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3172 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3172 ZOBELLIA_3173 ZOBELLIA_3173 gmdA gmdA 3674991 3676103 - GDP-mannose 4%2C6-dehydratase GDP-mannose 4%2C6-dehydratase converts GDP-mannose to GDP-4-dehydro-6-deoxy-D-mannose%2C the first of three steps for the conversion of GDP-mannose to GDP-fucose. GDP-L-fucose acts as a precursor of surface polysaccharidic antigens%3B Belongs to the Rossmann fold Superfamily%2C NAD-dependent epimerase/dehydratase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3173 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3173 ZOBELLIA_3174 ZOBELLIA_3174 ZOBELLIA_3174 3676312 3677688 - NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase belonging to the Rossmann fold family%3B Contains a twin-arginine translocation signal peptide cleaved between the residues 30 and 31%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3174 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3174 ZOBELLIA_3175 ZOBELLIA_3175 siaE1 siaE1 3677809 3679197 + Sialate O-acetylesterase Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid%2C N-acetylneuraminic acid%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3175 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3175 ZOBELLIA_3176 ZOBELLIA_3176 ZOBELLIA_3176 3679269 3681380 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 22 and 23%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3176 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3176 ZOBELLIA_3177 ZOBELLIA_3177 ZOBELLIA_3177 3681480 3683198 + FAD-dependent oxidoreductase Oxidoreductase that binds the FAD as prosthetic group to the FAD ADP-binding domain located in the N-terminal section of the protein%3B Belongs to the GMC (glucose-methanol-choline) oxidoreductase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3177 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3177 ZOBELLIA_3178 ZOBELLIA_3178 ZOBELLIA_3178 3683205 3683924 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 22 and 23%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3178 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3178 ZOBELLIA_3179 ZOBELLIA_3179 ZOBELLIA_3179 3684003 3684824 + Xylose isomerase-like TIM barrel protein Conserved protein belonging to the Xylose isomerase-like TIM barrel family%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Family membership gene gene3179 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3179 ZOBELLIA_318 ZOBELLIA_318 ZOBELLIA_318 410499 411386 - Gluconolactonase Gluconolactonase or Aldonolactonase hydrolyzes the glyconolactones formed by oxidoreductases acting on various aldohexosaccharides. It hydrolyzes the D-glucono-1%2C5-lactone to gluconic acid and can act on a wide range of hexono-1%2C5-lactones%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_318 ZOBELLIA_3180 ZOBELLIA_3180 ZOBELLIA_3180 3685021 3686877 + Conserved hypothetical lipoprotein Protein that could be involved in the carbohydrates metabolism%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3180 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3180 ZOBELLIA_3181 ZOBELLIA_3181 ddpX ddpX 3686964 3687692 + D-Ala-D-Ala dipeptidase%2C family M15 D-Ala-D-Ala dipeptidase hydrolyzes the D-Ala-D-Ala dipeptide%2C reducing its cellular pool so that only the resistant D-Ala-D-lactate dipeptide is incorporated into the peptidoglycan. Belongs to the family 15 of the metallopeptidases. The catalytic zinc is bound by conserved His%2C Asp and His residues. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm.%3B~High confidence in function and specificity gene gene3181 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3181 ZOBELLIA_3182 ZOBELLIA_3182 paeX paeX 3687707 3688621 + Pectin acetylesterase%2C family CE10 Pectin acetylesterase hydrolyzes acetyl groups in pectins%2C releasing acetates. This enzyme belongs to the family 10 of the carbohydrate esterases. Features a signal peptide cleaved between residues 18 and 19. Localized in the periplasm.%3B~High confidence in function and specificity gene gene3182 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3182 ZOBELLIA_3183 ZOBELLIA_3183 dssA dssA 3688679 3690256 - Sheath polysaccharide lyase Sheath polysaccharide lyase catalyzes the eliminative cleavage of bacterial polysaccharides containing uronic acids. Probably adopts a parallel beta-helix fold%3B Signal peptide cleaved between residues 21 and 22%3B Likely localized in the outer membrane%3B~High confidence in function and specificity gene gene3183 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3183 ZOBELLIA_3185 ZOBELLIA_3185 ZOBELLIA_3185 3690680 3690916 + Putative protein Hypothetical protein gene gene3185 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3185 ZOBELLIA_3186 ZOBELLIA_3186 ZOBELLIA_3186 3690898 3691101 + Putative protein Hypothetical protein gene gene3186 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3186 ZOBELLIA_3187 ZOBELLIA_3187 ZOBELLIA_3187 3691422 3692534 + Integron-related Integrase Integrase are site-specific tyrosine recombinases that act by catalyzing the cutting and rejoining of the recombining DNA molecules utilizing a catalytic tyrosine for the strand cleavage. These integrases includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and a secondary target%2C attC%2C present on various mobile gene cassettes%3B Contains a C-terminal Phage integrase domain%3B Belongs to the \\phage\\ integrase family%2C integron-related integrase subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene3187 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3187 ZOBELLIA_3188 ZOBELLIA_3188 ZOBELLIA_3188 3692877 3693194 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3188 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3188 ZOBELLIA_3189 ZOBELLIA_3189 ZOBELLIA_3189 3693247 3695433 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-99) and the Plug module (124-228) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene3189 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3189 ZOBELLIA_319 ZOBELLIA_319 ZOBELLIA_319 411405 412565 - Galactonate dehydratase Galactonate dehydratase converts the D-galactonate to 2-dehydro-3-deoxy-D-galactonate%3B Contains a N-terminal domain with a Enolase N-terminal domain-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase/muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_319 ZOBELLIA_3190 ZOBELLIA_3190 ZOBELLIA_3190 3695436 3695852 + Fur-type transcriptional regulator Transcriptional regulator featuring a helix-turn-helix DNA binding motif belonging to the Fur family. This family includes metal ion uptake regulator%2C that bind to the operator DNA and controls transcription of metal ion-responsive genes. Localized in the cytoplasm.%3B~Specificity unclear gene gene3190 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3190 ZOBELLIA_3191 ZOBELLIA_3191 ZOBELLIA_3191 3695906 3696490 + Conserved hypothetical membrane protein Could belong to the isoprenylcysteine carboxyl methyltransferase (ICMT) family%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3191 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3191 ZOBELLIA_3192 ZOBELLIA_3192 ZOBELLIA_3192 3696863 3697354 + Hypothetical membrane protein Contains three transmembrane helices. Localized in the cytoplasmic membrane.%3B~Hypothetical protein gene gene3192 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3192 ZOBELLIA_3193 ZOBELLIA_3193 ZOBELLIA_3193 3697547 3698398 + Hypothetical protein Putatively localized in the cytoplasm. gene gene3193 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3193 ZOBELLIA_3194 ZOBELLIA_3194 ZOBELLIA_3194 3698526 3699497 - Transposase%2C family 20 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 20 of transposases%3B Localized in the cytoplasm.%3B~Family membership gene gene3194 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3194 ZOBELLIA_3195 ZOBELLIA_3195 ZOBELLIA_3195 3699784 3701364 - Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene3195 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3195 ZOBELLIA_3196 ZOBELLIA_3196 ZOBELLIA_3196 3701572 3702219 + Hypothetical protein Putatively localized in the cytoplasm. gene gene3196 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3196 ZOBELLIA_3197 ZOBELLIA_3197 ZOBELLIA_3197 3702235 3702834 + Hypothetical protein Putatively localized in the cytoplasm. gene gene3197 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3197 ZOBELLIA_3198 ZOBELLIA_3198 ZOBELLIA_3198 3702966 3703187 - Putative protein Hypothetical protein gene gene3198 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3198 ZOBELLIA_3199 ZOBELLIA_3199 ZOBELLIA_3199 3703201 3703593 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3199 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3199 ZOBELLIA_32 ZOBELLIA_32 nadC nadC 32440 33297 - Quinolinate phosphoribosyl transferase [decarboxylating] Quinolinic acid phosphoribosyl transferase (QPRTase or QAPRTase) or nicotinate-nucleotide pyrophosphorylase catalyses the conversion of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP)%2C in the presence of Mg2+%2C to nicotinic acid mononucleotide (NAMN)%2C pyrophosphate and carbon dioxide. This enzyme provides the de novo source of NAMN for NAD biosynthesis%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_32 ZOBELLIA_320 ZOBELLIA_320 rraA2 rraA2 412611 413306 - Dimethylmenaquinone methyltransferase Regulator of ribonuclease activity is a general modulator of RNA abundance which inhibits the endonuclease activity of the RNase E and thereby leads to increase the half-life of RNAs%3B Contains a Demethylmenaquinone methyltransferase domain%3B Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_320 ZOBELLIA_3200 ZOBELLIA_3200 ZOBELLIA_3200 3703765 3704109 + Conserved hypothetical protein Conserved protein containing a tetratrico peptide repeat (TPR). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Localized in the cytoplasm gene gene3200 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3200 ZOBELLIA_3201 ZOBELLIA_3201 ZOBELLIA_3201 3704366 3704923 + Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene3201 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3201 ZOBELLIA_3202 ZOBELLIA_3202 ZOBELLIA_3202 3705006 3705815 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B~Family membership gene gene3202 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3202 ZOBELLIA_3203 ZOBELLIA_3203 ZOBELLIA_3203 3706031 3706378 + Hypothetical protein Putatively localized in the cytoplasm gene gene3203 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3203 ZOBELLIA_3204 ZOBELLIA_3204 ZOBELLIA_3204 3706618 3708192 - Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene3204 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3204 ZOBELLIA_3205 ZOBELLIA_3205 ZOBELLIA_3205 3708296 3708955 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3205 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3205 ZOBELLIA_3206 ZOBELLIA_3206 ZOBELLIA_3206 3709271 3710176 + Hypothetical protein Protein containing C-terminal leucine-rich repeats. Leucine-rich repeats consist of 2-45 motifs of 20-30 amino acids in length that generally folds into a horseshoe shape%3B Localized in the cytoplasm gene gene3206 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3206 ZOBELLIA_3207 ZOBELLIA_3207 ZOBELLIA_3207 3710532 3710963 + Glyoxalase family protein Protein of unknown function belonging to the glyocylase I family%3B Localized in the cytoplasm%3B~Family membership gene gene3207 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3207 ZOBELLIA_3208 ZOBELLIA_3208 ZOBELLIA_3208 3711225 3712451 - Oxidoreductase complex%2C membrane subunit This protein is the membrane subunit of a oxidoreductase complex of unknown specificity%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3208 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3208 ZOBELLIA_3209 ZOBELLIA_3209 ZOBELLIA_3209 3712533 3713663 - Oxidoreductase complex%2C iron-sulfur subunit This protein is the iron-sulfur subunit of a oxidoreductase of unknown specificity. It binds a 4Fe-4S cluster. This subunit interact with a membrane subunit%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3209 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3209 ZOBELLIA_321 ZOBELLIA_321 ZOBELLIA_321 413447 414322 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_321 ZOBELLIA_3210 ZOBELLIA_3210 ZOBELLIA_3210 3713674 3714303 - Diheme cytochrome c Protein that contains four consensus sequence Cys-x-x-Cys-His%2C where the histidine residue is one of the two axial ligands of the heme iron%3B Belongs to the Multiheme C-type cytochrome family%3B Putative lipoprotein signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~Function unclear gene gene3210 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3210 ZOBELLIA_3211 ZOBELLIA_3211 napB napB 3714293 3715015 - Diheme cytochrome c NapB The diheme cytochrome c napB is the small subunit of the periplasmic nitrate reductase (NAP). NapAB complex receives electrons from the membrane-anchored tetraheme napC protein%2C thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism. Features four consensus sequence Cys-x-x-Cys-His%2C where the histidine residue is one of the two axial ligands of the heme iron. Binds two hemes. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3211 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3211 ZOBELLIA_3212 ZOBELLIA_3212 napA napA 3715019 3717346 - Periplasmic nitrate reductase%2C catalytic subunit Catalytic subunit of the periplasmic nitrate reductase involved in the denitrification processes (nitrate assimilation by anaerobic respiration) reducing nitrate to nitrite. Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein napC%2C thus allowing electron flow between membrane and periplasm%3B Uses two molybdopterin guanine dinucleotide groups per subunit and 1 4Fe-4S cluster as cofactors%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Signal peptide cleaved between the residues 34 and 35%3B Exported by the twin arginine translocation pathway%3B~High confidence in function and specificity gene gene3212 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3212 ZOBELLIA_3213 ZOBELLIA_3213 ZOBELLIA_3213 3717358 3717591 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3213 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3213 ZOBELLIA_3214 ZOBELLIA_3214 moeA1 moeA1 3717908 3719089 + Molybdopterin biosynthesis protein Enzyme Involved in the biosynthesis of molybdopterin%2C necessary for molybdo-enzymes. MoeA%2C together with MoaB%2C is responsible for the metal incorporation into molybdopterin%2C the third step in molybdenum cofactor biosynthesis%3B Binds one magnesium ion%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3214 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3214 ZOBELLIA_3215 ZOBELLIA_3215 modE modE 3719099 3719440 + LysR-type transcriptional regulator The ModE-Mo complex acts as a repressor of genes involved in the transport of molybdate into the cell. Upon binding molybdate%2C the conformation of the protein changes%2C promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region%3B This protein consists of a LysR-type HTH domain only (the C-terminal domain is absent)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3215 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3215 ZOBELLIA_3216 ZOBELLIA_3216 moaE2 moaE2 3719535 3719975 + Molybdopterin synthase%2C large subunit Molybdopterin synthase converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group responsible for molybdenum ligation%3B The enzyme is a heterodimer of 2 small (moaD) subunits and 2 large (moaE) subunits%3B Localized in the cytoplasm%3B~Hypothetical protein gene gene3216 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3216 ZOBELLIA_3217 ZOBELLIA_3217 ZOBELLIA_3217 3720254 3721546 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3217 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3217 ZOBELLIA_3218 ZOBELLIA_3218 ZOBELLIA_3218 3721632 3722081 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3218 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3218 ZOBELLIA_3219 ZOBELLIA_3219 topB topB 3722580 3724880 + DNA topoisomerase III Topoisomerase III can be purified as a potent concatenase%2C but its role in DNA metabolism is still unclear%3B Belongs to the prokaryotic type I topoisomerase family%3B The type I topoisomerases catalyze the interconversion of DNA topoisomers by transient ATP-independent breakage of single-stranded DNA and the subsequent rejoining of the strands via a protein-DNA link where the hydroxyl group of a tyrosine residue is joined to a 5'-phosphate on DNA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3219 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3219 ZOBELLIA_322 ZOBELLIA_322 mroA1 mroA1 414390 415325 - Aldose 1-epimerase Aldose 1-epimerase or Mutarotase is responsible for the anomeric interconversion of aldoses between their alpha- and beta-forms%3B It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_322 ZOBELLIA_3220 ZOBELLIA_3220 ZOBELLIA_3220 3725129 3725887 - LuxR-type transcriptional regulator Transcriptional regulator belonging to the LuxR family. Features a C-terminal helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Specificity unclear gene gene3220 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3220 ZOBELLIA_3221 ZOBELLIA_3221 ZOBELLIA_3221 3726189 3728561 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (22-108) and the Plug module (122-217) acting as a channel gate%3B The signal peptide is putatively cleaved between the residues 25 and 26%3B~Family membership gene gene3221 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3221 ZOBELLIA_3222 ZOBELLIA_3222 ZOBELLIA_3222 3728686 3730317 - Fibronectin type-III repeats protein Conserved protein containing a N-terminal type-III fibronectin (FN3) domains. Structures of individual FN3 domains have revealed a conserved beta sandwich fold also found in bacterial glycosyde hydrolases and other proteins%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3222 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3222 ZOBELLIA_3223 ZOBELLIA_3223 ZOBELLIA_3223 3730380 3730559 + Putative protein Hypothetical protein gene gene3223 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3223 ZOBELLIA_3224 ZOBELLIA_3224 ZOBELLIA_3224 3730543 3731214 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3224 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3224 ZOBELLIA_3225 ZOBELLIA_3225 ZOBELLIA_3225 3731253 3731987 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3225 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3225 ZOBELLIA_3226 ZOBELLIA_3226 ZOBELLIA_3226 3732038 3732841 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3226 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3226 ZOBELLIA_3227 ZOBELLIA_3227 tyrDC tyrDC 3733156 3734655 - Tyrosine decarboxylase Tyrosine decarboxylase catalyzes the reaction : L-tyrosine %3D tyramine + CO2. This enzyme covalently binds the cofactor pyridoxal-phosphate (PLP) on a conserved lysine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3227 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3227 ZOBELLIA_3228 ZOBELLIA_3228 ZOBELLIA_3228 3734870 3735418 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3228 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3228 ZOBELLIA_3229 ZOBELLIA_3229 ZOBELLIA_3229 3735455 3736150 - Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3229 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3229 ZOBELLIA_323 ZOBELLIA_323 ZOBELLIA_323 415482 416870 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_323 ZOBELLIA_3230 ZOBELLIA_3230 ZOBELLIA_3230 3736205 3736780 - Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3230 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3230 ZOBELLIA_3231 ZOBELLIA_3231 ZOBELLIA_3231 3736777 3736878 - Putative protein Hypothetical protein gene gene3231 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3231 ZOBELLIA_3232 ZOBELLIA_3232 ZOBELLIA_3232 3737135 3737755 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3232 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3232 ZOBELLIA_3233 ZOBELLIA_3233 ZOBELLIA_3233 3737805 3738086 + Putative protein Hypothetical protein gene gene3233 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3233 ZOBELLIA_3234 ZOBELLIA_3234 ZOBELLIA_3234 3738604 3739068 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3234 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3234 ZOBELLIA_3235 ZOBELLIA_3235 ZOBELLIA_3235 3739117 3739323 + Putative protein Hypothetical protein gene gene3235 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3235 ZOBELLIA_3236 ZOBELLIA_3236 ZOBELLIA_3236 3739891 3740301 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3236 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3236 ZOBELLIA_3237 ZOBELLIA_3237 ZOBELLIA_3237 3740319 3741722 - PLP-dependent decarboxylase PLP-dependent decarboxylase catalyzes the decarboxylation of various substrates. Its exact specificity is not known. Uses pyridoxal-phosphate (PLP) as prosthetic group%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3237 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3237 ZOBELLIA_3238 ZOBELLIA_3238 ZOBELLIA_3238 3741850 3741987 + Putative protein Hypothetical protein gene gene3238 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3238 ZOBELLIA_3239 ZOBELLIA_3239 ZOBELLIA_3239 3742100 3742555 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3239 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3239 ZOBELLIA_324 ZOBELLIA_324 ZOBELLIA_324 416898 417581 - Creatinase family protein Conserved protein belonging to the creatine amidohydrolase family%3B Localized in the cytoplasm%3B~Family membership gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_324 ZOBELLIA_3240 ZOBELLIA_3240 ZOBELLIA_3240 3742545 3743108 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3240 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3240 ZOBELLIA_3241 ZOBELLIA_3241 ZOBELLIA_3241 3743243 3744067 - Conserved hypothetical membrane protein Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3241 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3241 ZOBELLIA_3242 ZOBELLIA_3242 ZOBELLIA_3242 3744170 3744376 - Putative protein Hypothetical protein gene gene3242 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3242 ZOBELLIA_3243 ZOBELLIA_3243 ZOBELLIA_3243 3744422 3746848 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (24-111) and the Plug module (125-224) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene3243 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3243 ZOBELLIA_3244 ZOBELLIA_3244 ZOBELLIA_3244 3746866 3746991 + Putative protein Hypothetical protein gene gene3244 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3244 ZOBELLIA_3245 ZOBELLIA_3245 ZOBELLIA_3245 3747045 3748208 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains four N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3245 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3245 ZOBELLIA_3246 ZOBELLIA_3246 ZOBELLIA_3246 3748189 3748959 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene3246 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3246 ZOBELLIA_3247 ZOBELLIA_3247 ZOBELLIA_3247 3748992 3749855 - GCN5-related N-acetyltransferase Contains two acetyltransferase domains%3B The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene3247 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3247 ZOBELLIA_3248 ZOBELLIA_3248 ZOBELLIA_3248 3749857 3750072 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3248 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3248 ZOBELLIA_3249 ZOBELLIA_3249 ZOBELLIA_3249 3750171 3751925 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3249 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3249 ZOBELLIA_325 ZOBELLIA_325 ZOBELLIA_325 417820 418806 - Sugar kinase Enzymes that catalyzes the phosphorylation of sugars from ATP%3B Contains a transmembrane segment in the middle part of protein%3B Belongs to the ROK family%3B Seems localized in the cytoplasmic membrane%3B~Family membership gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_325 ZOBELLIA_3250 ZOBELLIA_3250 nadR nadR 3752457 3753452 - Nicotinamide-nucleotide adenylyltransferase / Ribosylnicotinamide kinase Bifunctional enzyme involved in the nicotinate and nicotinamide metabolism possessing both NMN (nicotinamide mononucleotide) adenylytransferase (NMNAT) and Ribosylnicotinamide kinase (RNK) activities. NMNAT is an indispensable activity in the biosynthesis of NAD(+) and NADP(+) synthesizing NAD via the salvage pathway. RNK converts the N-ribosylnicotinamide to nicotinamide ribonucleotide%3B Localized in the cytoplasm. However%2C this bifunctional enzyme would loosely associate with the membrane through its interaction with the membrane-bound PnuC%3B~High confidence in function and specificity gene gene3250 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3250 ZOBELLIA_3251 ZOBELLIA_3251 pnuC2 pnuC2 3753445 3754074 - Nicotinamide mononucleotide transporter PnuC is the membrane protein responsible for nicotinamide mononucleotide transport%3B Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3251 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3251 ZOBELLIA_3252 ZOBELLIA_3252 ZOBELLIA_3252 3754074 3756071 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Does not contain of carboxypeptidase regulatory domain. The Plug module (41-152) acts as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene3252 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3252 ZOBELLIA_3253 ZOBELLIA_3253 ZOBELLIA_3253 3756094 3756663 - Conserved hypothetical protein Conserved protein containing two tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Localized in the cytoplasm gene gene3253 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3253 ZOBELLIA_3254 ZOBELLIA_3254 ZOBELLIA_3254 3756772 3757263 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene3254 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3254 ZOBELLIA_3255 ZOBELLIA_3255 ZOBELLIA_3255 3757569 3758231 - Conserved hypothetical lipoprotein Conserved lipoprotein that consists of a SCO1/SenC domain%3B Belongs to the SCO2/SenC family%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene3255 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3255 ZOBELLIA_3256 ZOBELLIA_3256 ZOBELLIA_3256 3758218 3758778 - Conserved hypothetical lipoprotein Conserved lipoprotein that contains three repeats of twenty aminoacids putatively The MORN (membrane occupation and recognition nexus) repeats would contribute to the plasma membrane binding%2C possibly by interacting with phospholipids%3B Signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3256 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3256 ZOBELLIA_3257 ZOBELLIA_3257 ZOBELLIA_3257 3758783 3759466 - Conserved hypothetical protein Localized in the cytoplasm gene gene3257 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3257 ZOBELLIA_3258 ZOBELLIA_3258 ZOBELLIA_3258 3759585 3760928 - Sulfatase%2C family S1-29 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 29%3B Lipoprotein with a signal peptide cleaved between the residues 18 and 19%3B localized in the outer membrane%3B~Family membership gene gene3258 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3258 ZOBELLIA_3259 ZOBELLIA_3259 ZOBELLIA_3259 3761473 3761931 - Hypothetical protein Putatively localized in the cytoplasm gene gene3259 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3259 ZOBELLIA_326 ZOBELLIA_326 ZOBELLIA_326 418818 420152 - FAD dependent oxidoreductase Flavoprotein that contains a N-terminal FAD binding domain%3B Belongs to the FAD/NAD(P)-binding Rossmann fold Superfamily%2C pyridine nucleotide-disulfide oxidoreductase family%3B Possible lipoprotein with a signal peptide cleaved between the residues 25 and 26%3B localized in the cytoplasmic membrane%3B~Function unclear gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_326 ZOBELLIA_3260 ZOBELLIA_3260 ZOBELLIA_3260 3762323 3762565 + Putative protein Hypothetical protein gene gene3260 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3260 ZOBELLIA_3261 ZOBELLIA_3261 ZOBELLIA_3261 3762686 3762835 - Putative protein Hypothetical protein gene gene3261 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3261 ZOBELLIA_3262 ZOBELLIA_3262 ZOBELLIA_3262 3763574 3764242 - Conserved hypothetical protein Localized in the cytoplasm gene gene3262 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3262 ZOBELLIA_3263 ZOBELLIA_3263 ZOBELLIA_3263 3764416 3765246 - Carbohydrate esterase%2C family CE1 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 1 of the carbohydrate esterases (CE1)%3B Signal peptide cleaved between residues 21 and 22%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3263 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3263 ZOBELLIA_3264 ZOBELLIA_3264 ZOBELLIA_3264 3765405 3765557 + Putative protein Hypothetical protein gene gene3264 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3264 ZOBELLIA_3265 ZOBELLIA_3265 ZOBELLIA_3265 3765549 3766325 - Conserved hypothetical protein Conserved hypothetical protein. This protein has likely a modular architecture%3B Localized in the cytoplasm gene gene3265 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3265 ZOBELLIA_3266 ZOBELLIA_3266 ZOBELLIA_3266 3766703 3767428 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene3266 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3266 ZOBELLIA_3267 ZOBELLIA_3267 ZOBELLIA_3267 3767590 3768474 + LysR-type transcriptional regulator Transcriptional regulator belonging to the LysR family. Features a N-terminal helix-turn-helix DNA binding domain and a C-terminal LysR-like substrate binding domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene3267 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3267 ZOBELLIA_3268 ZOBELLIA_3268 ZOBELLIA_3268 3768627 3769223 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3268 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3268 ZOBELLIA_3269 ZOBELLIA_3269 ZOBELLIA_3269 3769207 3770001 - Carbohydrate esterase%2C family CE1 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 1 of the carbohydrate esterases (CE1)%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3269 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3269 ZOBELLIA_327 ZOBELLIA_327 ZOBELLIA_327 420175 420969 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_327 ZOBELLIA_3270 ZOBELLIA_3270 ZOBELLIA_3270 3770074 3770682 - Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene3270 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3270 ZOBELLIA_3271 ZOBELLIA_3271 ZOBELLIA_3271 3770682 3770951 + Putative protein Hypothetical protein gene gene3271 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3271 ZOBELLIA_3272 ZOBELLIA_3272 nsrA nsrA 3771093 3772028 - Nisin-resistance protein%2C family S41 The protein NsrA is involved in nisin-resistance. It is a non-peptidase homologuous to peptidases S41. Although the catalytic serine is conserved%2C the catalytic lysine is replaced by a leucine%3B Belongs to the family S41 of the peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Function unclear gene gene3272 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3272 ZOBELLIA_3273 ZOBELLIA_3273 ZOBELLIA_3273 3772078 3772212 - Putative protein Hypothetical protein gene gene3273 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3273 ZOBELLIA_3274 ZOBELLIA_3274 ZOBELLIA_3274 3772289 3773866 + Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene3274 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3274 ZOBELLIA_3275 ZOBELLIA_3275 ZOBELLIA_3275 3774020 3774745 - Hypothetical membrane protein Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3275 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3275 ZOBELLIA_3276 ZOBELLIA_3276 ZOBELLIA_3276 3774768 3775289 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3276 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3276 ZOBELLIA_3277 ZOBELLIA_3277 ZOBELLIA_3277 3775456 3776952 - Amidohydrolase family protein The exact function of this protein is unknown%3B Belongs to the Amidohydrolase family%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Family membership gene gene3277 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3277 ZOBELLIA_3278 ZOBELLIA_3278 ZOBELLIA_3278 3776986 3777186 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3278 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3278 ZOBELLIA_3279 ZOBELLIA_3279 ZOBELLIA_3279 3777512 3777718 - Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3279 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3279 ZOBELLIA_328 ZOBELLIA_328 ZOBELLIA_328 421026 421832 - Conserved hypothetical protein Localized in the cytoplasm. gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_328 ZOBELLIA_3280 ZOBELLIA_3280 ZOBELLIA_3280 3777868 3778065 - Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3280 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3280 ZOBELLIA_3281 ZOBELLIA_3281 ZOBELLIA_3281 3778077 3778730 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3281 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3281 ZOBELLIA_3282 ZOBELLIA_3282 ZOBELLIA_3282 3779085 3779480 - Hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3282 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3282 ZOBELLIA_3283 ZOBELLIA_3283 ZOBELLIA_3283 3780578 3780988 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3283 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3283 ZOBELLIA_3284 ZOBELLIA_3284 ZOBELLIA_3284 3781254 3782831 + Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene3284 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3284 ZOBELLIA_3285 ZOBELLIA_3285 ZOBELLIA_3285 3782924 3785260 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3285 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3285 ZOBELLIA_3286 ZOBELLIA_3286 ZOBELLIA_3286 3785594 3786835 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene3286 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3286 ZOBELLIA_3287 ZOBELLIA_3287 ZOBELLIA_3287 3786861 3787961 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3287 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3287 ZOBELLIA_3288 ZOBELLIA_3288 ZOBELLIA_3288 3788177 3790312 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3288 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3288 ZOBELLIA_3289 ZOBELLIA_3289 ZOBELLIA_3289 3790635 3790988 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3289 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3289 ZOBELLIA_329 ZOBELLIA_329 ZOBELLIA_329 421840 422592 - GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B Contains an N-terminal HTH domain of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA and a C-terminal UTRA domain that modulates activity of transcription regulator in response to binding small molecules%3B Localized in the cytoplasm%3B~Family membership gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_329 ZOBELLIA_3290 ZOBELLIA_3290 ZOBELLIA_3290 3790989 3791654 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3290 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3290 ZOBELLIA_3291 ZOBELLIA_3291 ereA ereA 3792068 3793798 - Erythromycin esterase Erythromycin esterase confers resistance to erythromycin through inactivation by hydrolyzing the lactone ring of the antibiotic. Also contains a N-terminal domain of unknown function. Localized in the cytoplasm.%3B~Hypothetical protein gene gene3291 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3291 ZOBELLIA_3292 ZOBELLIA_3292 ZOBELLIA_3292 3794223 3794801 - Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3292 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3292 ZOBELLIA_3293 ZOBELLIA_3293 ZOBELLIA_3293 3795053 3795580 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3293 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3293 ZOBELLIA_3294 ZOBELLIA_3294 ZOBELLIA_3294 3795635 3796297 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3294 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3294 ZOBELLIA_3295 ZOBELLIA_3295 ZOBELLIA_3295 3796334 3796951 - Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3295 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3295 ZOBELLIA_3296 ZOBELLIA_3296 ZOBELLIA_3296 3797170 3797751 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 16 and 17%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3296 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3296 ZOBELLIA_3297 ZOBELLIA_3297 ZOBELLIA_3297 3798152 3800008 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Lipoprotein signal peptide cleaved between the residues 23 and 24%3B Contains four N-terminal tetratrico peptide repeats (TPR) and one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3297 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3297 ZOBELLIA_3298 ZOBELLIA_3298 ZOBELLIA_3298 3800001 3800738 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene3298 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3298 ZOBELLIA_3299 ZOBELLIA_3299 ZOBELLIA_3299 3800846 3801256 + Conserved hypothetical protein Probably a cytoplasmic protein gene gene3299 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3299 ZOBELLIA_33 ZOBELLIA_33 ZOBELLIA_33 33427 33900 + Conserved hypothetical protein Conserved hypothetical protein belonging to the family DUF163. Localized in the cytoplasm. gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_33 ZOBELLIA_330 ZOBELLIA_330 ZOBELLIA_330 422589 422690 - Putative protein Hypothetical protein gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_330 ZOBELLIA_3300 ZOBELLIA_3300 ZOBELLIA_3300 3801314 3801967 + Hypothetical protein Probably a cytoplasmic protein gene gene3300 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3300 ZOBELLIA_3301 ZOBELLIA_3301 ZOBELLIA_3301 3801979 3803259 + Hypothetical protein Probably a cytoplasmic protein gene gene3301 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3301 ZOBELLIA_3302 ZOBELLIA_3302 ZOBELLIA_3302 3803271 3804761 + Metalloendopeptidase%2C family M48 Peptidase family M48 contains metalloendopeptidases. This peptidase contains a single catalytic zinc ion tetrahedrally co-ordinated by two histidines within an HEXXH motif%2C an as yet undetermined third residue and water. The glutamate within the HEXXH motif is assumed to be a catalytic residue. Localized in the cytoplasm.%3B~Specificity unclear gene gene3302 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3302 ZOBELLIA_3303 ZOBELLIA_3303 ZOBELLIA_3303 3804776 3804982 - Putative protein Hypothetical protein gene gene3303 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3303 ZOBELLIA_3304 ZOBELLIA_3304 ZOBELLIA_3304 3805130 3807757 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (21-107) and the Plug module (120-210) acting as a channel gate. The signal peptide is cleaved between the residues 16 and 17.%3B~Family membership gene gene3304 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3304 ZOBELLIA_3305 ZOBELLIA_3305 ZOBELLIA_3305 3807758 3808543 - Conserved hypothetical protein Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space gene gene3305 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3305 ZOBELLIA_3306 ZOBELLIA_3306 ZOBELLIA_3306 3808688 3808936 + Putative protein Hypothetical protein gene gene3306 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3306 ZOBELLIA_3307 ZOBELLIA_3307 ZOBELLIA_3307 3809163 3809633 - Hypothetical protein Putatively localized in the cytoplasm gene gene3307 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3307 ZOBELLIA_3308 ZOBELLIA_3308 ZOBELLIA_3308 3809727 3810134 - Hypothetical protein Putatively localized in the cytoplasm gene gene3308 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3308 ZOBELLIA_3309 ZOBELLIA_3309 ZOBELLIA_3309 3810365 3811132 - Conserved hypothetical protein Localized in the cytoplasm gene gene3309 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3309 ZOBELLIA_331 ZOBELLIA_331 ZOBELLIA_331 422690 423346 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_331 ZOBELLIA_3310 ZOBELLIA_3310 cutF cutF 3811204 3811983 - Copper homeostasis protein CutF CutF is involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes%3B Contains a C-terminal domain of unknown function DUF306%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the cytoplasmic and/or outer membrane%3B~High confidence in function and specificity gene gene3310 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3310 ZOBELLIA_3311 ZOBELLIA_3311 ZOBELLIA_3311 3812210 3812842 - Hypothetical membrane protein Contains an uncleaved signal sequence%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3311 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3311 ZOBELLIA_3312 ZOBELLIA_3312 ZOBELLIA_3312 3812861 3812998 - Putative protein Hypothetical protein gene gene3312 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3312 ZOBELLIA_3313 ZOBELLIA_3313 ZOBELLIA_3313 3813050 3814033 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3313 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3313 ZOBELLIA_3314 ZOBELLIA_3314 ZOBELLIA_3314 3814126 3814785 - Hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene3314 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3314 ZOBELLIA_3315 ZOBELLIA_3315 ZOBELLIA_3315 3814816 3815073 - Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3315 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3315 ZOBELLIA_3316 ZOBELLIA_3316 ZOBELLIA_3316 3815245 3815484 + Putative protein Hypothetical protein gene gene3316 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3316 ZOBELLIA_3317 ZOBELLIA_3317 ZOBELLIA_3317 3815446 3816021 - Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene3317 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3317 ZOBELLIA_3318 ZOBELLIA_3318 ribB ribB 3816022 3816684 - 3%2C4-Dihydroxy-2-butanone 4-phosphate synthase 3%2C4-Dihydroxy-2-butanone 4-phosphate (DHBP) synthase catalyzes the formation of DHBP from ribulose 5- phosphate. DHBP serves as the biosynthetic precursor for the xylene ring of riboflavin. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3318 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3318 ZOBELLIA_3319 ZOBELLIA_3319 ZOBELLIA_3319 3818240 3818455 + Putative protein Hypothetical protein gene gene3320 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3319 ZOBELLIA_332 ZOBELLIA_332 mdsA1 mdsA1 423644 425263 - Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Specificity unclear gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_332 ZOBELLIA_3320 ZOBELLIA_3320 ZOBELLIA_3320 3817061 3818251 - Metallophosphoesterase Modular enzyme containing a N-terminal Fibronectin type III domain and a C-terminal metallophosphoesterase domain. The most conserved regions in the metallophosphoesterase family centre around the metal chelating residues%3B Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasm%3B~Specificity unclear gene gene3319 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3320 ZOBELLIA_3321 ZOBELLIA_3321 ZOBELLIA_3321 3818573 3818773 + Putative protein Hypothetical protein gene gene3321 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3321 ZOBELLIA_3322 ZOBELLIA_3322 ZOBELLIA_3322 3818869 3819642 - Alpha-L-fucosidase%2C family GH29%2C C-terminal fragment Consists of a C-terminal alpha-L-fucosidase domain%3B The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B~High confidence in function and specificity gene gene3322 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3322 ZOBELLIA_3323 ZOBELLIA_3323 ZOBELLIA_3323 3819763 3820674 - Alpha-L-fucosidase%2C family GH29%2C N-terminal fragment Consists of an N-terminal alpha-L-fucosidase domain%3B The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha- L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Contains a transmembrane segment%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3323 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3323 ZOBELLIA_3324 ZOBELLIA_3324 ZOBELLIA_3324 3821035 3821703 - RNA pseudouridine synthase Enzyme responsible for synthesis of pseudouridine from uracil in tRNA or rRNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Belongs to the pseudouridine synthase RluA family%3B localized in the cytoplasm%3B~Specificity unclear gene gene3324 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3324 ZOBELLIA_3325 ZOBELLIA_3325 ZOBELLIA_3325 3821747 3823699 - Radical SAM superfamily protein Radical SAM proteins catalyze diverse reactions%2C including unusual methylations%2C isomerization%2C sulphur insertion%2C ring formation%2C anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S center. The exact function of this protein is unclear. Localized in the cytoplasm.%3B~Family membership gene gene3325 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3325 ZOBELLIA_3326 ZOBELLIA_3326 doxDA doxDA 3824286 3825302 - Thiosulphate:quinone oxidoreductase Thiosulfate:quinone oxidoreductase (TQO)%2C also known as thiosulfate dehydrogenase (quinone)%2C is involved in sulfur oxidation pathway. TQO oxidized thiosulphate with tetrathionate as product and ferricyanide or decyl ubiquinone (DQ) as electron acceptors. In the archaeon Acidianus ambivalens%2C TQO is constituted by a large subunit%2C DoxD%2C and a small subunit%2C DoxA. Here%2C DoxD and DoxA are fused and constitute the N- and C-terminal domains of this enzyme%2C respectively. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3326 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3326 ZOBELLIA_3327 ZOBELLIA_3327 ZOBELLIA_3327 3825472 3825849 - Hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 27 and 28%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene3327 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3327 ZOBELLIA_3328 ZOBELLIA_3328 ZOBELLIA_3328 3826174 3826671 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3328 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3328 ZOBELLIA_3329 ZOBELLIA_3329 ZOBELLIA_3329 3826983 3828161 - Conserved hypothetical membrane protein Protein that displays two parts: a N-terminal part that cooperatively binds calcium ions by two EF-hand domains and a conserved C-terminal part of unknown function%3B Putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3329 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3329 ZOBELLIA_333 ZOBELLIA_333 ZOBELLIA_333 425282 427549 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Hypothetical protein gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_333 ZOBELLIA_3330 ZOBELLIA_3330 ZOBELLIA_3330 3828270 3828704 + Transposase (fragment)%2C family 11 Possible inactive fragment of transposase. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Could belong to the family 11 of transposases%3B Putatively localized in the cytoplasm%3B~Conserved hypothetical protein gene gene3330 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3330 ZOBELLIA_3331 ZOBELLIA_3331 ZOBELLIA_3331 3828771 3829184 - Conserved hypothetical protein Localized in the cytoplasm gene gene3331 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3331 ZOBELLIA_3332 ZOBELLIA_3332 ZOBELLIA_3332 3829490 3830257 - Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3332 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3332 ZOBELLIA_3333 ZOBELLIA_3333 ZOBELLIA_3333 3830889 3832166 - Voltage-gated chloride channel Chloride channels constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. Features nine transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3333 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3333 ZOBELLIA_3334 ZOBELLIA_3334 ZOBELLIA_3334 3832508 3834031 - PKD-containing protein Protein that shares one central PKD module (146-230). The presence of this domain would suggest that the protein possess an extracellular segment%3B Probably the PKD module functions as a ligand binding site in protein-protein or protein-carbohydrate interactions%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Family membership gene gene3334 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3334 ZOBELLIA_3335 ZOBELLIA_3335 ZOBELLIA_3335 3834056 3834988 - Hypothetical lipoprotein Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic and/or outer membrane%3B~Hypothetical protein gene gene3335 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3335 ZOBELLIA_3336 ZOBELLIA_3336 ZOBELLIA_3336 3834975 3836819 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 29 and 30%3B Probably localized in the outer membrane%3B~Family membership gene gene3336 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3336 ZOBELLIA_3337 ZOBELLIA_3337 ZOBELLIA_3337 3836820 3839645 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Usually%3B Contains a Plug module (43-138) acting as a channel gate%3B The signal peptide is cleaved between the residues 23 and 24%3B~Family membership gene gene3337 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3337 ZOBELLIA_3338 ZOBELLIA_3338 ZOBELLIA_3338 3839665 3841581 - SusD/RagB family protein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Probably localized in the outer membrane%3B~Family membership gene gene3338 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3338 ZOBELLIA_3339 ZOBELLIA_3339 ZOBELLIA_3339 3841584 3844739 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (33-108) and the Plug module (124-231) acting as a channel gate%3B The signal peptide is cleaved between the residues 30 and 31%3B~Family membership gene gene3339 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3339 ZOBELLIA_334 ZOBELLIA_334 ZOBELLIA_334 427645 429750 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_334 ZOBELLIA_3340 ZOBELLIA_3340 ZOBELLIA_3340 3845347 3847206 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3340 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3340 ZOBELLIA_3341 ZOBELLIA_3341 ZOBELLIA_3341 3847234 3847452 - Putative protein Hypothetical protein gene gene3341 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3341 ZOBELLIA_3342 ZOBELLIA_3342 ZOBELLIA_3342 3847669 3848841 + Conserved hypothetical protein Contains a central transmembrane helix%3B Localized in the cytoplasmic membrane. gene gene3342 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3342 ZOBELLIA_3343 ZOBELLIA_3343 ZOBELLIA_3343 3849117 3850160 - LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene3343 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3343 ZOBELLIA_3344 ZOBELLIA_3344 ZOBELLIA_3344 3850413 3853511 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (40-114) and the Plug module (131-254) acting as a channel gate%3B The signal peptide is cleaved between the residues 35 and 36%3B~Family membership gene gene3344 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3344 ZOBELLIA_3345 ZOBELLIA_3345 ZOBELLIA_3345 3853523 3854887 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3BContains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Probably localized in the outer membrane%3B~Family membership gene gene3345 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3345 ZOBELLIA_3346 ZOBELLIA_3346 ZOBELLIA_3346 3854926 3856368 + Fasciclin family protein Protein containing an N-terminal FAS1 (or BIgH3) module. In eucariotic cells%2C this module is involved in the process of cell adhesion. Contains a signal peptide cleaved between the residues 24 and 25. Localized in the outer membrane.%3B~Hypothetical protein gene gene3346 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3346 ZOBELLIA_3347 ZOBELLIA_3347 ZOBELLIA_3347 3856386 3857162 + Glycoside hydrolase%2C family GH16 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. Belongs to the family 16 of the glycoside hydrolases. Contains a signal peptide of lipoprotein cleaved between the residues 30 and 31. Localized in the outer membrane.%3B~Specificity unclear gene gene3347 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3347 ZOBELLIA_3348 ZOBELLIA_3348 nagB1 nagB1 3857209 3857970 + Glucosamine-6-phosphate deaminase Glucosamine-6-phosphate deaminase or Glucosamine-6-phosphate isomerase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion in the N-acetylglucosamine (GlcNAC) utilization pathway%3B Belongs to the glucosamine/galactosamine-6-phosphate isomerase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3348 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3348 ZOBELLIA_3349 ZOBELLIA_3349 ZOBELLIA_3349 3857999 3859561 + Glycoside hydrolase%2C family GH20 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety. Belongs to the family 20 of the glycoside hydrolases. Carbonyl oxygen of the C-2 acetamido group of the substrate acts as the catalytic nucleophile/base in the family GH20. Features a signal peptide cleaved between residues 27 and 28. Localized in the periplasm.%3B~Specificity unclear gene gene3349 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3349 ZOBELLIA_335 ZOBELLIA_335 ZOBELLIA_335 429957 432275 - Beta-helix fold protein This conserved protein likely adopts a right handed parallel beta-helix fold. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_335 ZOBELLIA_3350 ZOBELLIA_3350 ZOBELLIA_3350 3859621 3861099 + Sodium/solute symporter Sodium/substrate symport is a mechanism of solute transport across cytoplasmic membranes cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains 13 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3350 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3350 ZOBELLIA_3351 ZOBELLIA_3351 nagA nagA 3861104 3862252 + N-acetylglucosamine-6-phosphate deacetylase N-acetylglucosamine-6-phosphate deacetylase%2C induced by N-acetylglucosamine%2C hydrolyses the N-acetyl-D-glucosamine 6-phosphate to D-glucosamine 6-phosphate in the N-acetylglucosamine utilization pathway%3B Belongs to the Amidohydrolase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3351 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3351 ZOBELLIA_3352 ZOBELLIA_3352 nahA3 nahA3 3862308 3863900 + Beta-N-acetylhexosaminidase%2C family GH20 Beta-N-acetylhexosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. Carbonyl oxygen of the C-2 acetamido group of the substrate acts as the catalytic nucleophile/base%3B Belongs to the family 20 of the glycoside hydrolases (GH20)%3B Signal peptide cleaved between residues 22 and 23%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3352 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3352 ZOBELLIA_3353 ZOBELLIA_3353 ZOBELLIA_3353 3863970 3865034 - Serine peptidase%2C family S12 Serine peptidase belonging to the family S12. The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa-Thr-Lys%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%2C Localized in the outer membrane%3B~Function unclear gene gene3353 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3353 ZOBELLIA_3354 ZOBELLIA_3354 ZOBELLIA_3354 3865319 3865948 + Conserved hypothetical lipoprotein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG). Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3354 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3354 ZOBELLIA_3355 ZOBELLIA_3355 pfpI pfpI 3866163 3866738 - Intracellular peptidase%2C family C56 This peptidase belongs to the family 56 of the cysteine peptidases (C56). The catalytic diad is constituted by two consecutive residues%2C Cys and His. The enzyme forms a hexameric ring structure%2C and the active sites are proposed to be formed at the interfaces between three pairs of monomers. Localized in the cytoplasm.%3B~Specificity unclear gene gene3355 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3355 ZOBELLIA_3356 ZOBELLIA_3356 ZOBELLIA_3356 3867296 3870418 + TonB-dependent receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-98) and the Plug module (114-221) acting as a channel gate%3B The signal peptide is cleaved between the residues 22 and 23%3B~Family membership gene gene3356 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3356 ZOBELLIA_3357 ZOBELLIA_3357 ZOBELLIA_3357 3870430 3872094 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3357 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3357 ZOBELLIA_3358 ZOBELLIA_3358 ZOBELLIA_3358 3872357 3873103 - Conserved hypothetical protein This conserved protein belongs to the DUF71 family%2C which is predicted to bind ATP. It features a strongly conserved motif SGGKD at the N terminus. It is a two-domain protein with a N-terminal Rossmann fold domain and a C-terminal alpha/beta domain. Localized in the cytoplasm.%3B~Family membership gene gene3358 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3358 ZOBELLIA_3359 ZOBELLIA_3359 ZOBELLIA_3359 3873142 3873255 - Putative protein Hypothetical protein gene gene3359 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3359 ZOBELLIA_336 ZOBELLIA_336 ZOBELLIA_336 432298 433767 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Putative lipoprotein with a signal peptide cleaved between the residues 18 and 19. Possibly localized in the outer membrane%3B~Family membership gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_336 ZOBELLIA_3360 ZOBELLIA_3360 ZOBELLIA_3360 3873330 3874583 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3360 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3360 ZOBELLIA_3361 ZOBELLIA_3361 ZOBELLIA_3361 3874835 3875092 + Putative protein Hypothetical protein gene gene3361 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3361 ZOBELLIA_3362 ZOBELLIA_3362 ZOBELLIA_3362 3876138 3877271 - Hypothetical protein Putatively localized in the cytoplasm. gene gene3362 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3362 ZOBELLIA_3363 ZOBELLIA_3363 ZOBELLIA_3363 3877625 3878758 - Conserved hypothetical membrane protein Contains four N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3363 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3363 ZOBELLIA_3364 ZOBELLIA_3364 ZOBELLIA_3364 3878842 3879081 - Putative protein Hypothetical protein gene gene3364 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3364 ZOBELLIA_3365 ZOBELLIA_3365 ZOBELLIA_3365 3879171 3879485 + Hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3365 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3365 ZOBELLIA_3366 ZOBELLIA_3366 ZOBELLIA_3366 3879584 3881179 + Sulfate transporter Protein containing a C-terminal STAS domain (Sulphate Transporter and AntiSigma factor antagonist)%2C which has been suggested to have have a general NTP binding function%3B belongs to the sulfate transporter family%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3366 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3366 ZOBELLIA_3367 ZOBELLIA_3367 canA3 canA3 3881199 3881840 + Carbonate dehydratase Carbonate dehydratase (or carbonic anhydrases) is a zinc metalloenzyme which catalyzes the reversible hydration of carbon dioxide . It belongs to the beta class of carbonic anhydrases. It forms a homodimer and binds one zinc ion by subunit. In bacteria%2C this enzyme is usually involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase. By this action%2C it prevents the depletion of cellular bicarbonate Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3367 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3367 ZOBELLIA_3368 ZOBELLIA_3368 ZOBELLIA_3368 3882026 3882172 - Putative protein Hypothetical protein gene gene3368 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3368 ZOBELLIA_3369 ZOBELLIA_3369 ZOBELLIA_3369 3882267 3882371 + Putative protein Hypothetical protein gene gene3369 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3369 ZOBELLIA_337 ZOBELLIA_337 ZOBELLIA_337 433779 436157 - Beta-helix fold protein containing CBM16 Modular protein containing a N-terminal domain adopting a parallel beta-helix fold and a C-terminal carbohydrate binding module of the family 16 (CBM16). The N-terminal domain is distantly related to the polysaccharide lyases of the family 9 (PL9). Features a signal peptide cleaved between residues 29 and 30. Localized in the periplasm.%3B~Specificity unclear gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_337 ZOBELLIA_3370 ZOBELLIA_3370 ZOBELLIA_3370 3882514 3883194 + Metal-dependent hydrolase This protein belongs to the zinc-dependent beta-lactamase superfamily and is likely a metal-dependent hydrolase%3B Localized in the cytoplasm%3B~Family membership gene gene3370 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3370 ZOBELLIA_3371 ZOBELLIA_3371 ZOBELLIA_3371 3883291 3883686 - Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3371 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3371 ZOBELLIA_3372 ZOBELLIA_3372 ZOBELLIA_3372 3883816 3884298 - Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3372 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3372 ZOBELLIA_3373 ZOBELLIA_3373 ZOBELLIA_3373 3884299 3884655 - Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3373 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3373 ZOBELLIA_3374 ZOBELLIA_3374 ZOBELLIA_3374 3885056 3885265 - Putative protein Hypothetical protein gene gene3374 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3374 ZOBELLIA_3375 ZOBELLIA_3375 ZOBELLIA_3375 3885517 3885651 + Putative protein Hypothetical protein gene gene3375 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3375 ZOBELLIA_3376 ZOBELLIA_3376 porC porC 3885700 3886767 + Beta-porphyranase C%2C family GH16 The beta-porphyranases hydrolyse the 1%2C4-beta-D-galactosidic linkages in porphyrans%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide of lipoprotein cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene3376 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3376 ZOBELLIA_3377 ZOBELLIA_3377 ZOBELLIA_3377 3886868 3887275 - Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3377 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3377 ZOBELLIA_3378 ZOBELLIA_3378 ZOBELLIA_3378 3887315 3887527 - Putative protein Hypothetical protein gene gene3378 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3378 ZOBELLIA_3379 ZOBELLIA_3379 ZOBELLIA_3379 3887518 3887625 - Putative protein Hypothetical protein gene gene3379 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3379 ZOBELLIA_338 ZOBELLIA_338 alfA3 alfA3 436290 437732 - Alpha-L-fucosidase%2C family GH29 Modular protein that consists of an N-terminal alpha-L-fucosidase module belonging to the family 29 of glycoside hydrolases (GH29)%2C responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside and a C-terminal domain that could be involved in the binding to specific ligands such as carbohydrate or lipids substrates%3B Signal peptide cleaved between the residue 18 and 19%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_338 ZOBELLIA_3380 ZOBELLIA_3380 ZOBELLIA_3380 3887648 3888205 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3380 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3380 ZOBELLIA_3381 ZOBELLIA_3381 ZOBELLIA_3381 3888324 3888752 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3381 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3381 ZOBELLIA_3382 ZOBELLIA_3382 ZOBELLIA_3382 3888765 3889223 - Conserved hypothetical protein Protein fragment found in the C-terminal of the Rhs family proteins%3B Possibly localized in the cytoplasm gene gene3382 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3382 ZOBELLIA_3383 ZOBELLIA_3383 ZOBELLIA_3383 3889635 3889877 - Putative protein Hypothetical protein gene gene3383 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3383 ZOBELLIA_3384 ZOBELLIA_3384 ZOBELLIA_3384 3889868 3890071 - Putative protein Hypothetical protein gene gene3384 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3384 ZOBELLIA_3385 ZOBELLIA_3385 ZOBELLIA_3385 3890314 3890859 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3385 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3385 ZOBELLIA_3386 ZOBELLIA_3386 ZOBELLIA_3386 3890990 3891418 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3386 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3386 ZOBELLIA_3387 ZOBELLIA_3387 ZOBELLIA_3387 3891431 3895492 - Rhs family protein This conserved protein belongs to the Rhs family. It contains numerous repeats featuring a YD dipeptide%2C the most strongly conserved motif of the repeat. In Escherichia coli%2C a rhsA mutation reduces K5 biosynthesis suggesting a role for RhsA in coupling biosynthesis and export of capsular polysaccharides. Localized in the cytoplasm.%3B~Family membership gene gene3387 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3387 ZOBELLIA_3388 ZOBELLIA_3388 ZOBELLIA_3388 3895505 3896842 - Conserved hypothetical protein Localized in the cytoplasm gene gene3388 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3388 ZOBELLIA_3389 ZOBELLIA_3389 ZOBELLIA_3389 3896848 3898629 - Vgr family protein Conserved protein belonging to the Vgr family. The Vgr family proteins are associated with some classes of Rhs elements%3B Localized in the cytoplasm%3B~Family membership gene gene3389 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3389 ZOBELLIA_339 ZOBELLIA_339 alfaA2 alfaA2 437735 439222 - Alpha-L-fucosidase%2C family GH29 Modular protein that consists of an N-terminal alpha-L-fucosidase module belonging to the family 29 of glycoside hydrolases (GH29)%2C responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside and a C-terminal domain of two hundred residues that could be involved in the binding to specific ligands such as carbohydrate or lipids substrates%3B Signal peptide cleaved between the residue 19 and 20%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_339 ZOBELLIA_3390 ZOBELLIA_3390 ZOBELLIA_3390 3898792 3898920 - Putative protein Hypothetical protein gene gene3390 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3390 ZOBELLIA_3391 ZOBELLIA_3391 ZOBELLIA_3391 3899676 3900314 - Hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3391 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3391 ZOBELLIA_3392 ZOBELLIA_3392 ZOBELLIA_3392 3900416 3900571 - Putative protein Hypothetical protein gene gene3392 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3392 ZOBELLIA_3393 ZOBELLIA_3393 ZOBELLIA_3393 3901025 3901939 - Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3393 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3393 ZOBELLIA_3394 ZOBELLIA_3394 ZOBELLIA_3394 3902304 3902888 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3394 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3394 ZOBELLIA_3395 ZOBELLIA_3395 ZOBELLIA_3395 3902956 3903393 - Conserved hypothetical protein Localized in the cytoplasm gene gene3395 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3395 ZOBELLIA_3396 ZOBELLIA_3396 ZOBELLIA_3396 3903557 3903892 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3396 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3396 ZOBELLIA_3397 ZOBELLIA_3397 ZOBELLIA_3397 3904047 3904742 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3397 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3397 ZOBELLIA_3398 ZOBELLIA_3398 ZOBELLIA_3398 3905344 3906432 - Conserved hypothetical protein Localized in the cytoplasm gene gene3398 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3398 ZOBELLIA_3399 ZOBELLIA_3399 ZOBELLIA_3399 3906774 3907025 + Putative protein Hypothetical protein gene gene3399 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3399 ZOBELLIA_34 ZOBELLIA_34 serB/serA1 serB/serA1 33966 35858 - Phosphoserine phosphatase / D-3-phosphoglycerate dehydrogenase Bifunctional enzyme with a N-terminal phosphoserine phosphatase (SerB) and a C-terminal D-3-phosphoglycerate dehydrogenase (SerA) involved in the third and first step of the serine biosynthesis pathway respectively%3B SerA converts the 3-phosphonooxypyruvate to 3-phosphoglycerate. It is composed of a substrate-binding domain belonging to the D-isomer specific 2-hydroxyacid dehydrogenase family and a NAD-binding domain (Rossman fold). SerA features also a C-terminal ACT domain that adopts a ferredoxin-like fold. confering to SerA a feedback inhibition by L-serine%3B SerB converts the L(or D)-3-phospho-serine to L-serine. It requires magnesium as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_34 ZOBELLIA_340 ZOBELLIA_340 ZOBELLIA_340 439278 441716 - Beta-helix fold protein This conserved protein likely adopts a right handed parallel beta-helix fold. Features a signal peptide cleaved between the residues 32 and 33. Localized in the periplasm.%3B~Conserved hypothetical protein gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_340 ZOBELLIA_3400 ZOBELLIA_3400 ZOBELLIA_3400 3907302 3907937 - Hypothetical protein Localized in the cytoplasm gene gene3400 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3400 ZOBELLIA_3401 ZOBELLIA_3401 ZOBELLIA_3401 3908056 3908274 + Putative protein Hypothetical protein gene gene3401 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3401 ZOBELLIA_3402 ZOBELLIA_3402 ZOBELLIA_3402 3908237 3909055 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3402 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3402 ZOBELLIA_3403 ZOBELLIA_3403 ZOBELLIA_3403 3909302 3910057 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3403 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3403 ZOBELLIA_3404 ZOBELLIA_3404 ZOBELLIA_3404 3910285 3910872 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3404 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3404 ZOBELLIA_3405 ZOBELLIA_3405 ZOBELLIA_3405 3911131 3911679 - Hypothetical protein gene gene3405 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3405 ZOBELLIA_3406 ZOBELLIA_3406 ZOBELLIA_3406 3911782 3911910 - Putative protein Hypothetical protein gene gene3406 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3406 ZOBELLIA_3407 ZOBELLIA_3407 ZOBELLIA_3407 3911925 3912116 + Putative protein Hypothetical protein gene gene3407 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3407 ZOBELLIA_3408 ZOBELLIA_3408 ZOBELLIA_3408 3912211 3912336 - Putative protein Hypothetical protein gene gene3408 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3408 ZOBELLIA_3409 ZOBELLIA_3409 ZOBELLIA_3409 3912461 3913291 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3409 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3409 ZOBELLIA_341 ZOBELLIA_341 fucA2 fucA2 441724 442842 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 24 and 25%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_341 ZOBELLIA_3410 ZOBELLIA_3410 ZOBELLIA_3410 3913495 3914115 + Conserved hypothetical lipoprotein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG). Contains a prokaryotic lipoprotein signal peptide cleaved between tyhe residues 22 and 23%3B Localized in the outer membrane%3B~Function unclear gene gene3410 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3410 ZOBELLIA_3411 ZOBELLIA_3411 ZOBELLIA_3411 3914193 3914447 + Putative protein Hypothetical protein gene gene3411 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3411 ZOBELLIA_3412 ZOBELLIA_3412 ZOBELLIA_3412 3914786 3915766 + Kelch repeats protein Protein containing six Kelch repeats. The kelch motif forms a beta sheet and several of these sheets associate to form a beta propeller structure%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Family membership gene gene3412 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3412 ZOBELLIA_3413 ZOBELLIA_3413 ZOBELLIA_3413 3915763 3915900 - Putative protein Hypothetical protein gene gene3413 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3413 ZOBELLIA_3414 ZOBELLIA_3414 ZOBELLIA_3414 3915915 3916040 + Putative protein Hypothetical protein gene gene3414 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3414 ZOBELLIA_3415 ZOBELLIA_3415 ZOBELLIA_3415 3916037 3916963 + Conserved hypothetical lipoprotein lipoprotein containing five tandem peptide repeats of 25 or 26 residues in the C-terminal part of the protein suggesting that this protein is a surface protein%3B Belongs to the DUF285 family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3415 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3415 ZOBELLIA_3416 ZOBELLIA_3416 ZOBELLIA_3416 3917266 3918324 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3416 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3416 ZOBELLIA_3417 ZOBELLIA_3417 ZOBELLIA_3417 3918417 3919391 - Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3417 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3417 ZOBELLIA_3418 ZOBELLIA_3418 ZOBELLIA_3418 3919611 3920198 + Conserved hypothetical protein Localized in the cytoplasm gene gene3418 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3418 ZOBELLIA_3419 ZOBELLIA_3419 ZOBELLIA_3419 3920183 3920281 + Putative protein Hypothetical protein gene gene3419 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3419 ZOBELLIA_342 ZOBELLIA_342 fucA1 fucA1 442842 444326 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 25 and 26%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_342 ZOBELLIA_3420 ZOBELLIA_3420 ZOBELLIA_3420 3920290 3921312 - Conserved hypothetical protein Localized in the cytoplasm gene gene3420 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3420 ZOBELLIA_3421 ZOBELLIA_3421 ZOBELLIA_3421 3921294 3922853 - Conserved hypothetical protein Localized in the cytoplasm gene gene3421 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3421 ZOBELLIA_3422 ZOBELLIA_3422 ZOBELLIA_3422 3923147 3924727 + Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Localized in the cytoplasm%3B~Family membership gene gene3422 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3422 ZOBELLIA_3423 ZOBELLIA_3423 ZOBELLIA_3423 3924712 3924822 + Putative protein Hypothetical protein gene gene3423 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3423 ZOBELLIA_3424 ZOBELLIA_3424 ZOBELLIA_3424 3924819 3925868 - Conserved hypothetical protein Localized in the cytoplasm gene gene3424 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3424 ZOBELLIA_3425 ZOBELLIA_3425 ZOBELLIA_3425 3926031 3927143 - Conserved hypothetical protein Localized in the cytoplasm gene gene3425 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3425 ZOBELLIA_3426 ZOBELLIA_3426 ZOBELLIA_3426 3927259 3927399 - Putative protein Hypothetical protein gene gene3426 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3426 ZOBELLIA_3427 ZOBELLIA_3427 ZOBELLIA_3427 3927393 3927563 - Putative protein Hypothetical protein gene gene3427 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3427 ZOBELLIA_3428 ZOBELLIA_3428 ZOBELLIA_3428 3927733 3927903 + Putative protein Hypothetical protein gene gene3428 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3428 ZOBELLIA_3429 ZOBELLIA_3429 ZOBELLIA_3429 3927916 3929370 + FAD-dependent pyridine nucleotide-disulphide oxidoreductase Oxidoreductase that uses the FAD and NADH as coenzyme%3B Belongs to the pyridine nucleotide-disulphide oxidoreductase superfamily%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3429 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3429 ZOBELLIA_343 ZOBELLIA_343 afcA2 afcA2 444330 446705 - Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Features a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_343 ZOBELLIA_3430 ZOBELLIA_3430 ZOBELLIA_3430 3929449 3929550 + Conserved hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3430 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3430 ZOBELLIA_3431 ZOBELLIA_3431 ZOBELLIA_3431 3929547 3929747 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3431 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3431 ZOBELLIA_3432 ZOBELLIA_3432 ZOBELLIA_3432 3929905 3931206 + Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Family membership gene gene3432 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3432 ZOBELLIA_3433 ZOBELLIA_3433 ZOBELLIA_3433 3931311 3932423 + Membrane fusion protein These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region%3B~Family membership gene gene3433 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3433 ZOBELLIA_3434 ZOBELLIA_3434 ZOBELLIA_3434 3932562 3935795 + Multidrug efflux transporter Integral membrane protein involved in drug resistance that belongs to the acrB/acrD/acrF family%3B Contains 12 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2%2C and helices 7 and 8. The three transmembrane domains form a large%2C 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3434 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3434 ZOBELLIA_3435 ZOBELLIA_3435 ZOBELLIA_3435 3935776 3936117 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3435 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3435 ZOBELLIA_3436 ZOBELLIA_3436 ZOBELLIA_3436 3936172 3936342 + Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3436 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3436 ZOBELLIA_3437 ZOBELLIA_3437 ZOBELLIA_3437 3936441 3938738 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-95) and the Plug module (109-215) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene3437 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3437 ZOBELLIA_3438 ZOBELLIA_3438 ZOBELLIA_3438 3938816 3939154 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3438 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3438 ZOBELLIA_3439 ZOBELLIA_3439 ZOBELLIA_3439 3939479 3943651 + One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one trans membrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3439 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3439 ZOBELLIA_344 ZOBELLIA_344 xarB1 xarB1 446715 448931 - Xylosidase/arabinosidase%2C family GH3 XarB catalyzes the hydrolysis of terminal%2C non-reducing beta-D-xylose residues (or L-arabinose residues) with release of beta-D-xylose (or alpha-L-arabinose). This bifunctional enzyme belongs to the family 3 of the glycoside hydrolases (GH3)%3B Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasm.%3B~High confidence in function and specificity gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_344 ZOBELLIA_3440 ZOBELLIA_3440 ZOBELLIA_3440 3943767 3945668 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 24 and 25%3B Possibly localized in the outer membrane%3B~Family membership gene gene3440 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3440 ZOBELLIA_3441 ZOBELLIA_3441 ZOBELLIA_3441 3945690 3949004 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (50-125) and the Plug module (141-250) acting as a channel gate%3B The signal peptide is cleaved between the residues 34 and 35%3B~Family membership gene gene3441 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3441 ZOBELLIA_3442 ZOBELLIA_3442 ZOBELLIA_3442 3949088 3949189 + Putative protein Hypothetical protein gene gene3442 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3442 ZOBELLIA_3443 ZOBELLIA_3443 ZOBELLIA_3443 3949241 3949348 - Putative protein Hypothetical protein gene gene3443 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3443 ZOBELLIA_3444 ZOBELLIA_3444 ZOBELLIA_3444 3949369 3949578 + Putative protein Hypothetical protein gene gene3444 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3444 ZOBELLIA_3445 ZOBELLIA_3445 uglA1 uglA1 3949760 3950959 + Unsaturated glucuronyl hydrolase%2C family GH88 Unsaturated glucuronyl hydrolase is involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. UglA catalyzes the hydrolysis of oligosaccharides with unsaturated uronic acids at the nonreducing terminal%2C to a sugar or an amino sugar%2C and an unsaturated uronic acid%2C which is nonenzymatically converted immediately to alpha-keto acid%3B Belongs to the family 88 of the glycoside hydrolases (GH88)%3B Signal peptide cleaved between residues 22 and 23. Localized in the periplasmic space%3B~Specificity unclear gene gene3445 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3445 ZOBELLIA_3446 ZOBELLIA_3446 ZOBELLIA_3446 3951070 3951933 + Carbohydrate esterase%2C family CE10 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 10 of the carbohydrate esterases (CE10)%3B Signal peptide cleaved between residues 19 and 20%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3446 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3446 ZOBELLIA_3447 ZOBELLIA_3447 ZOBELLIA_3447 3951938 3953416 + Sulfatase%2C family S1-23 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 23%3B Possible signal peptide of lipoprotein cleaved between the residues 23 and 24%3B Putatively localized in the outer membrane%3B~Family membership gene gene3447 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3447 ZOBELLIA_3448 ZOBELLIA_3448 mdsA3 mdsA3 3953506 3955023 + Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Signal peptide cleaved between the residues 22 and 23%3B Seems localized in the periplasmic space%3B~Specificity unclear gene gene3448 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3448 ZOBELLIA_3449 ZOBELLIA_3449 ZOBELLIA_3449 3955065 3957890 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 32 and 33%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3449 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3449 ZOBELLIA_345 ZOBELLIA_345 fucA3 fucA3 448955 450451 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_345 ZOBELLIA_3450 ZOBELLIA_3450 ZOBELLIA_3450 3957906 3960278 + Beta-helix fold protein Protein that likely adopts a right handed parallel beta-helix fold%3B Contains a C-terminal PDZ domain responsible of protein-protein interaction by binding either the carboxyl-terminal sequences of proteins or internal peptide sequences suggesting that it could be a signaling protein%3B Prokaryotic lipoprotein signal peptide cleaved between 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3450 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3450 ZOBELLIA_3451 ZOBELLIA_3451 alfA5 alfA5 3960295 3962274 + Alpha-L-fucosidase%2C family GH29 / Acetylesterase Modular protein with a N-terminal alpha-L-fucosidase module belonging to the family 29 of the glycoside hydrolases (GH29) and a C-terminal acetyl esterase domain belonging to the lipase-GDSL family which includes families 3 and 12 of the carbohydrate esterases (CE3/CE12)%3B Catalytic activities: an alpha-L-fucoside + H2O %3D L-fucose + an alcohol and an acetic ester + H2O %3D an alcohol + acetate%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3451 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3451 ZOBELLIA_3452 ZOBELLIA_3452 ZOBELLIA_3452 3962566 3964872 + Polysaccharide lyase%2C family PL15 Polysaccharide lyase catalyses the eliminative cleavage of polysaccharides containing uronic acids. Belongs to the family 15 of the polysaccharide lyases. Up to now%2C the only known activity in family PL15 is oligo-alginate lyase (EC 4.2.2.-). Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene3452 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3452 ZOBELLIA_3453 ZOBELLIA_3453 ZOBELLIA_3453 3964874 3966544 + Possible pyridine nucleotide-disulphide oxidoreductase Possible flavoproteins belonging to the family of pyridine nucleotide-disulphide oxidoreductases%3B Contains a signal peptide of lipoprotein cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene3453 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3453 ZOBELLIA_3454 ZOBELLIA_3454 ZOBELLIA_3454 3966546 3967271 + Acetylesterase%2C lipase-GDSL family Acetylesterase that belongs to the lipase-GDSL Pfam family%2C which includes families 3 and 12 of the carbohydrate esterases (CE3 and CE12)%3B The conserved catalytic residues are Ser31%2C Asp172 and His175%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3454 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3454 ZOBELLIA_3455 ZOBELLIA_3455 ZOBELLIA_3455 3967278 3969110 + Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Contains a N-terminal transmembrane helix%3B Possibly localized in the cytoplasmic membrane%3B~Family membership gene gene3455 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3455 ZOBELLIA_3456 ZOBELLIA_3456 ZOBELLIA_3456 3969205 3969984 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 32 and 33%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3456 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3456 ZOBELLIA_3457 ZOBELLIA_3457 ZOBELLIA_3457 3969981 3971189 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3457 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3457 ZOBELLIA_3458 ZOBELLIA_3458 ZOBELLIA_3458 3971195 3972508 + Sugars permease The Sugars permeases belong to the major facilitator superfamily (MFS) transporters that are single- polypeptide secondary carriers capable only of transporting small solutes (probably sugars in this case) in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3458 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3458 ZOBELLIA_3459 ZOBELLIA_3459 kduI3 kduI3 3972528 3973358 + 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase The 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase or 5-keto-4-deoxyuronate isomerase (DKI isomerase) is involved in the pectin degradation in the pectinolytic microorganisms%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3459 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3459 ZOBELLIA_346 ZOBELLIA_346 alfA1 alfA1 450465 452453 - Alpha-L-fucosidase%2C family GH29 Modular protein that consists of an N-terminal alpha-L-fucosidase module belonging to the family 29 of glycoside hydrolases (GH29)%2C responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside and a C-terminal domain that could be involved in the binding to specific ligands such as carbohydrate or lipids substrates%3B Signal peptide cleaved between the residue 22 and 23%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_346 ZOBELLIA_3460 ZOBELLIA_3460 kduD2 kduD2 3973388 3974155 + 2-keto-3-deoxygluconate oxidoreductase The 2-keto-3-deoxygluconate oxidoreductase or 2-deoxy-D-gluconate 3-dehydrogenase is involved in the pectin degradation in the pectinolytic microorganisms%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3460 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3460 ZOBELLIA_3461 ZOBELLIA_3461 ZOBELLIA_3461 3974189 3975670 + Sulfatase%2C family S1-28 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 28%3B Putative lipoprotein with a signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~Family membership gene gene3461 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3461 ZOBELLIA_3462 ZOBELLIA_3462 ZOBELLIA_3462 3975686 3977350 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3462 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3462 ZOBELLIA_3463 ZOBELLIA_3463 ZOBELLIA_3463 3977512 3978381 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3463 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3463 ZOBELLIA_3464 ZOBELLIA_3464 alfA4 alfA4 3978903 3980711 + Alpha-L-fucosidase%2C family GH29 Modular protein that consists of an N-terminal alpha-L-fucosidase module belonging to the family 29 of glycoside hydrolases (GH29)%2C responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside and a C-terminal domain that could be involved in the binding to specific ligands such as carbohydrate or lipids substrates%3B Signal peptide cleaved between the residue 27 and 28%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3464 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3464 ZOBELLIA_3465 ZOBELLIA_3465 ZOBELLIA_3465 3980785 3982395 + Sulfatase%2C family S1-15 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 15%3B Signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Family membership gene gene3465 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3465 ZOBELLIA_3466 ZOBELLIA_3466 ZOBELLIA_3466 3982434 3983843 + Sulfatase%2C family S1-22 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 22%3B Signal peptide of lipoprotein cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane and/or in the cytoplasmic membranes%3B~Family membership gene gene3466 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3466 ZOBELLIA_3467 ZOBELLIA_3467 ZOBELLIA_3467 3984212 3987355 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly sulphated sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (53-126) and the Plug module (142-258) acting as a channel gate%3B The signal peptide is cleaved between the residues 37 and 38%3B~Family membership gene gene3467 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3467 ZOBELLIA_3468 ZOBELLIA_3468 ZOBELLIA_3468 3987372 3988877 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B~Family membership gene gene3468 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3468 ZOBELLIA_3469 ZOBELLIA_3469 ZOBELLIA_3469 3988949 3990796 + Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Contains a N-terminal transmembrane helix%3B Seems localized in the cytoplasmic membrane%3B~Family membership gene gene3469 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3469 ZOBELLIA_347 ZOBELLIA_347 xarB2 xarB2 452462 454867 - Xylosidase/arabinosidase%2C family GH3 XarB catalyzes the hydrolysis of terminal%2C non-reducing beta-D-xylose residues (or L-arabinose residues) with release of beta-D-xylose (or alpha-L-arabinose). This bifunctional enzyme belongs to the family 3 of the glycoside hydrolases. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_347 ZOBELLIA_3470 ZOBELLIA_3470 ZOBELLIA_3470 3990905 3992419 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 34 and 35%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3470 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3470 ZOBELLIA_3471 ZOBELLIA_3471 ZOBELLIA_3471 3992707 3994032 + Galactonate dehydratase Galactonate dehydratase converts the D-galactonate to 2-dehydro-3-deoxy-D-galactonate. It is Involved in the galactose metabolism. These enzymes feature a N-terminal domain with a Enolase N-terminal domain-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase/muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3471 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3471 ZOBELLIA_3472 ZOBELLIA_3472 ZOBELLIA_3472 3994040 3994816 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene3472 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3472 ZOBELLIA_3473 ZOBELLIA_3473 ZOBELLIA_3473 3994871 3995725 + Fumarylacetoacetate hydrolase family protein Conserved protein belonging to the Fumarylacetoacetate hydrolase family%2C but its exact function is not known%3B Localized in the cytoplasm.%3B~Family membership gene gene3473 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3473 ZOBELLIA_3474 ZOBELLIA_3474 ZOBELLIA_3474 3995733 3996518 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene3474 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3474 ZOBELLIA_3475 ZOBELLIA_3475 fucP1 fucP1 3996527 3997846 + L-fucose-proton symporter FucP mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose%2C but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3475 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3475 ZOBELLIA_3476 ZOBELLIA_3476 lldD2 lldD2 3997916 3999085 + L-lactate dehydrogenase [cytochrome] L-lactate dehydrogenase is involved in L-lactate degradation converting the L-lactate to pyruvate%3B Uses flavin mononucleotide (FMN) as prosthetic group%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3476 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3476 ZOBELLIA_3477 ZOBELLIA_3477 ZOBELLIA_3477 3999103 3999738 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 14 and 15%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3477 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3477 ZOBELLIA_3478 ZOBELLIA_3478 ZOBELLIA_3478 3999888 4000328 - Conserved hypothetical protein Localized in the cytoplasm gene gene3478 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3478 ZOBELLIA_3479 ZOBELLIA_3479 ZOBELLIA_3479 4000388 4001758 - Metallo-beta-lactamase superfamily protein Conserved protein belonging to the zinc-dependent beta-lactamase superfamily. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions%3B Localized in the cytoplasm%3B~Function unclear gene gene3479 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3479 ZOBELLIA_348 ZOBELLIA_348 ZOBELLIA_348 455478 459566 + One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_348 ZOBELLIA_3480 ZOBELLIA_3480 ZOBELLIA_3480 4001762 4002607 - Conserved hypothetical protein Localized in the cytoplasm gene gene3480 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3480 ZOBELLIA_3481 ZOBELLIA_3481 ZOBELLIA_3481 4002634 4003539 - Small-conductance mechanosensitive channel Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains three transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3481 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3481 ZOBELLIA_3482 ZOBELLIA_3482 ZOBELLIA_3482 4003546 4003653 + Putative protein Hypothetical protein gene gene3482 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3482 ZOBELLIA_3483 ZOBELLIA_3483 ZOBELLIA_3483 4003650 4004489 - Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains two copies of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS- box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene3483 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3483 ZOBELLIA_3484 ZOBELLIA_3484 ZOBELLIA_3484 4004554 4005405 - Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains one N-terminal copy of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS-box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene3484 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3484 ZOBELLIA_3485 ZOBELLIA_3485 trxA trxA 4005546 4005845 + Thioredoxin Thioredoxin is a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3485 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3485 ZOBELLIA_3486 ZOBELLIA_3486 ZOBELLIA_3486 4005954 4006952 + Conserved hypothetical protein Localized in the cytoplasm gene gene3486 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3486 ZOBELLIA_3487 ZOBELLIA_3487 uppA uppA 4007258 4007911 + Uracil phosphoribosyltransferase Uracil phosphoribosyltransferase is involved in pyrimidine metabolism. In presence of diphosphate%2C it converts UMP to uracyl and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP)%3B Uses magnesium ion as a cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3487 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3487 ZOBELLIA_3488 ZOBELLIA_3488 pmr1 pmr1 4007949 4010456 - Calcium-transporting P-type ATPase Pmr1 is Aa P-type ATPase responsible for calcium efflux using ATP hydrolysis for energy. Pmr1 controls calcium homeostasis. Belongs to the cation transport P-type ATPase family. Features nine transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3488 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3488 ZOBELLIA_3489 ZOBELLIA_3489 ZOBELLIA_3489 4010664 4011746 + Membrane fusion protein These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region%3B~Family membership gene gene3489 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3489 ZOBELLIA_349 ZOBELLIA_349 ZOBELLIA_349 459907 460818 - Hypothetical lipoprotein Contains a lipoprotein signal peptide claeved between the residues 17 and 18%3B Putatively localized in the outer membrane%3B~Hypothetical protein gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_349 ZOBELLIA_3490 ZOBELLIA_3490 lolC lolC 4011743 4013005 + Lipoprotein releasing system%2C permease component Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the cytoplasmic membrane. Such a release is dependent of lolA and of the sorting-signal of the mature lipoprotein (absence of an Asp at position 2)%3B Contains four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3490 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3490 ZOBELLIA_3491 ZOBELLIA_3491 lolD lolD 4013016 4013690 + Lipoprotein releasing system%2C ATPase component This protein is the nucleotide-binding domain of the Lipoprotein releasing system%3B Part of the ABC transporter complex lolC (Transmembrane protein)%2C lolD (ATP-binding protein)%2C lolE (Transmembrane protein) involved in the translocation of mature outer membrane- directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C lolA. Responsible for the formation of the lolA-lipoprotein complex in an ATP-dependent manner%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~High confidence in function and specificity gene gene3491 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3491 ZOBELLIA_3492 ZOBELLIA_3492 ZOBELLIA_3492 4013797 4014183 + Conserved hypothetical protein Localized in the cytoplasm gene gene3492 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3492 ZOBELLIA_3493 ZOBELLIA_3493 ZOBELLIA_3493 4014198 4015172 + Conserved hypothetical protein Localized in the cytoplasm gene gene3493 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3493 ZOBELLIA_3494 ZOBELLIA_3494 ZOBELLIA_3494 4015189 4015653 - Conserved hypothetical protein Localized in the cytoplasm gene gene3494 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3494 ZOBELLIA_3495 ZOBELLIA_3495 ZOBELLIA_3495 4015631 4015771 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3495 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3495 ZOBELLIA_3496 ZOBELLIA_3496 ZOBELLIA_3496 4015800 4016006 + Putative membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3496 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3496 ZOBELLIA_3497 ZOBELLIA_3497 ZOBELLIA_3497 4016009 4016437 - Conserved hypothetical protein Localized in the cytoplasm gene gene3497 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3497 ZOBELLIA_3498 ZOBELLIA_3498 ZOBELLIA_3498 4016608 4017123 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3498 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3498 ZOBELLIA_3499 ZOBELLIA_3499 ZOBELLIA_3499 4017322 4018200 - Conserved hypothetical membrane protein Conserved protein belonging to the DUF808 family%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3499 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3499 ZOBELLIA_35 ZOBELLIA_35 ZOBELLIA_35 36022 36822 - Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Signal peptide of lipoprotein cleaved between the residues 24 and 25%3B Possibly localized in the outer membrane%3B~Function unclear gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_35 ZOBELLIA_350 ZOBELLIA_350 ZOBELLIA_350 460847 462541 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Probably localized in the outer membrane%3B~Family membership gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_350 ZOBELLIA_3500 ZOBELLIA_3500 ZOBELLIA_3500 4018905 4019222 - Hypothetical protein Localized in the cytoplasm gene gene3500 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3500 ZOBELLIA_3501 ZOBELLIA_3501 ZOBELLIA_3501 4019270 4020505 + ROK-type transcriptional repressor ROK-type transcriptional repressors are involved in the repression of genes encoding for sugars-utilizing enzymes and are important in the coordination of catabolic and transport operons%3B Contains a N-terminal helix-turn-helix (HTH) DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA%3B Belongs to the ROK (nagC/xylR) family%3B Localized in the cytoplasm%3B~Family membership gene gene3501 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3501 ZOBELLIA_3502 ZOBELLIA_3502 ZOBELLIA_3502 4020561 4022417 + Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Putative lipoprotein signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~Family membership gene gene3502 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3502 ZOBELLIA_3503 ZOBELLIA_3503 ZOBELLIA_3503 4022450 4023859 + Sulfatase%2C family S1-25 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 25%3B Lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Family membership gene gene3503 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3503 ZOBELLIA_3504 ZOBELLIA_3504 ZOBELLIA_3504 4024072 4027116 + CBM35-containing protein Large protein containing a central carbohydrate binding module of the family 35 (CBM35) and at least two other domains of unknown function%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3504 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3504 ZOBELLIA_3505 ZOBELLIA_3505 mdsA4 mdsA4 4027164 4028735 + Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Putative lipoprotein with a signal peptide cleaved between the residues 23 and 24%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene3505 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3505 ZOBELLIA_3506 ZOBELLIA_3506 ZOBELLIA_3506 4028748 4029557 + Carbohydrate esterase%2C family CE6 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides. The catalytic machinery is a Ser-His-Asp triad%3B Belongs to the family 6 of the carbohydrate esterases CE6)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3506 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3506 ZOBELLIA_3507 ZOBELLIA_3507 ZOBELLIA_3507 4029751 4032924 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (30-103) and the Plug module (119-227) acting as a channel gate%3B The signal peptide is cleaved between the residues 29 and 30%3B~Family membership gene gene3507 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3507 ZOBELLIA_3508 ZOBELLIA_3508 ZOBELLIA_3508 4032935 4034653 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B~Family membership gene gene3508 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3508 ZOBELLIA_3509 ZOBELLIA_3509 ZOBELLIA_3509 4034723 4036156 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Putative lipoprotein signal peptide cleaved between the residues 21 and 22%3B Possibly localized in the outer membrane%3B~Family membership gene gene3509 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3509 ZOBELLIA_351 ZOBELLIA_351 ZOBELLIA_351 462558 465536 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (31-94) and the Plug module (123-217) acting as a channel gate%3B The signal peptide is cleaved between the residues 24 and 25%3B~Family membership gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_351 ZOBELLIA_3510 ZOBELLIA_3510 ZOBELLIA_3510 4036299 4040423 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3510 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3510 ZOBELLIA_3511 ZOBELLIA_3511 ZOBELLIA_3511 4040752 4043799 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly sulphated sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B This sequence does not contain of carboxypeptidase regulatory domain. The Plug module (111- 221) acts as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene3511 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3511 ZOBELLIA_3512 ZOBELLIA_3512 ZOBELLIA_3512 4043810 4045369 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 21 and 22%3B Probably localized in the outer membrane%3B~Family membership gene gene3512 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3512 ZOBELLIA_3513 ZOBELLIA_3513 ZOBELLIA_3513 4045438 4046904 + Sulfatase%2C family S1-20 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Family membership gene gene3513 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3513 ZOBELLIA_3514 ZOBELLIA_3514 ZOBELLIA_3514 4047084 4047737 + GDSL-like Lipase/Acylhydrolase family Protein that consists of a GDSL-like Lipase/Acylhydrolase domain%3B Seems to have an uncleavable N-terminal signal sequence%3B Possibly localized in the cytoplasmic membrane%3B~Family membership gene gene3514 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3514 ZOBELLIA_3515 ZOBELLIA_3515 ZOBELLIA_3515 4047828 4049456 + Sulfatase%2C family S1-20 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~Family membership gene gene3515 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3515 ZOBELLIA_3516 ZOBELLIA_3516 ZOBELLIA_3516 4049499 4051037 + Endo-1%2C4-beta-xylanase%2C family GH5 Endo-1%2C4-beta-xylanase catalyzes the endohydrolysis of 1%2C4-beta-D-xylosidic linkages in xylans. This enzyme belongs to the family 5 of the glycoside hydrolases. Features a signal peptide cleaved between residues 19 and 20. Localized in the periplasm.%3B~High confidence in function and specificity gene gene3516 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3516 ZOBELLIA_3517 ZOBELLIA_3517 ZOBELLIA_3517 4051065 4053164 + Sulfatase%2C family S1-20 Modular protein consisting of a N-terminal domain belonging to the family 1 of sulfatases and a C-terminal PA14 domain putatively involved in the protein or carbohydrate binding%3B The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Contains a lipoprotein signal peptide cleaved between the residues 21 and 22%3B localized in the outer membrane%3B~Family membership gene gene3517 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3517 ZOBELLIA_3518 ZOBELLIA_3518 ZOBELLIA_3518 4053192 4054952 - Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3518 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3518 ZOBELLIA_3519 ZOBELLIA_3519 ZOBELLIA_3519 4055030 4056502 - Sulfatase%2C family S1-27 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 27%3B Possible lipoprotein signal peptide cleaved between the residues 27 and 28%3B Putatively localized in the outer membrane%3B~Family membership gene gene3519 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3519 ZOBELLIA_352 ZOBELLIA_352 ZOBELLIA_352 465562 467346 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Probably localized in the outer membrane%3B~Family membership gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_352 ZOBELLIA_3520 ZOBELLIA_3520 siaE2 siaE2 4056566 4057987 - Sialate O-acetylesterase Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid%2C N-acetylneuraminic acid. Features a signal peptide cleaved between the residues 24 and 25. Localized in the periplasm.%3B~High confidence in function and specificity gene gene3520 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3520 ZOBELLIA_3521 ZOBELLIA_3521 ZOBELLIA_3521 4058019 4060367 - Hypothetical protein Putatively localized in the cytoplasm. gene gene3521 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3521 ZOBELLIA_3522 ZOBELLIA_3522 rhaA rhaA 4060483 4063023 - Alpha-L-rhamnosidase%2C family GH78 Alpha-L-rhamnosidase catalyzes the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. It belongs to the family 78 of the glycoside hydrolases. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3522 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3522 ZOBELLIA_3523 ZOBELLIA_3523 ZOBELLIA_3523 4063091 4065691 - Carbohydrate esterase%2C family CE6 / Alpha-galactosidase%2C family GH27 This enzyme is a modular protein consisting of a N-terminal module belonging to the family 6 of the carbohydrate esterases (CE6%3B 26-342)%2C a central alpha-galactosidase domain belonging to family 27 of the glycoside hydrolases (GH27%3B 343-733) and a C-terminal domain of unknown function (734-866). Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides. The catalytic machinery is a Ser-His-Asp triad. Alpha-galactosidase catalyzes the hydrolysis of terminal%2C non-reducing alpha-D-galactose residues in alpha-D-galactosides%2C including galactose oligosaccharides%3B Signal peptide cleaved between residues 25 and 26%3B Localized in the periplasm%3B~Specificity unclear gene gene3523 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3523 ZOBELLIA_3524 ZOBELLIA_3524 ZOBELLIA_3524 4065716 4068283 - Acetylesterase%2C lipase-GDSL family Modular protein with a N-terminal acetylesterase (lipase-GDSL family)%2C which includes families 3 and 12 of the carbohydrate esterases (CE3 and CE12)%2C a central alpha/beta hydrolase fold domain and a C-terminal GDSL_hydrolase fold domain%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3524 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3524 ZOBELLIA_3525 ZOBELLIA_3525 ZOBELLIA_3525 4068322 4069773 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Family membership gene gene3525 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3525 ZOBELLIA_3526 ZOBELLIA_3526 idsA4 idsA4 4069879 4071426 - Iduronate-2-sulfatase%2C family S1-7 Iduronate-2-sulfatase%2C called also chondroitinsulfatase is involved in the glycosaminoglycan degradation. It hydrolyzes the 2-sulfate groups from non-reducing-terminal iduronic acid residues in dermatan sulfate%2C heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 7%3B Lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane or/and cytoplasmic membrane%3B~High confidence in function and specificity gene gene3526 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3526 ZOBELLIA_3527 ZOBELLIA_3527 ZOBELLIA_3527 4071820 4073427 + Sulfatase%2C family S1-20 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 20%3B Contains a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane%3B~Family membership gene gene3527 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3527 ZOBELLIA_3528 ZOBELLIA_3528 ZOBELLIA_3528 4073672 4074241 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3528 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3528 ZOBELLIA_3529 ZOBELLIA_3529 ZOBELLIA_3529 4074445 4075506 + anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3530 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3529 ZOBELLIA_353 ZOBELLIA_353 ZOBELLIA_353 467356 470490 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (24-97) and the Plug module (113-222) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_353 ZOBELLIA_3530 ZOBELLIA_3530 ZOBELLIA_3530 4074245 4074445 - Putative protein Hypothetical protein gene gene3529 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3530 ZOBELLIA_3531 ZOBELLIA_3531 ZOBELLIA_3531 4075722 4079027 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (49-100)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (111-183)%2C and a Plug module (199-309) acting as the channel gate%3B The signal peptide is cleaved between the residue 22 and 23%3B~Family membership gene gene3531 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3531 ZOBELLIA_3532 ZOBELLIA_3532 ZOBELLIA_3532 4079038 4080711 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Family membership gene gene3532 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3532 ZOBELLIA_3533 ZOBELLIA_3533 bgaC bgaC 4080886 4083378 + Beta-galactosidase%2C family GH2 Enzyme belonging to the family 2 of glycoside hydrolases (GH2) which catalyzes the hydrolysis of the beta-1%2C4 linkage at the terminal non-reducing%2C releasing a beta-D-galactose residue from beta-D-galactosides%3B Putative signal peptide cleaved between residues 19 and 20%3B Possibly localized in the periplasmic space%3B~High confidence in function and specificity gene gene3533 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3533 ZOBELLIA_3534 ZOBELLIA_3534 afcA4 afcA4 4083428 4085806 + Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Signal peptide cleaved between residues the residues 25 and 26%3B Localized in the periplsamic space%3B~High confidence in function and specificity gene gene3534 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3534 ZOBELLIA_3535 ZOBELLIA_3535 afcA5 afcA5 4085806 4088235 + Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%2C Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Signal peptide cleaved between residues 25 and 26%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3535 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3535 ZOBELLIA_3536 ZOBELLIA_3536 phoD1 phoD1 4088370 4089881 - Alkaline phosphatase Alkaline phosphatase is a zinc and magnesium-containing metalloenzyme which hydrolyzes phosphate esters%2C optimally at high pH%3B Alkaline phosphatase exists as a dimer%2C each monomer binding 2 zinc atoms and one magnesium atom%2C which are essential for enzymic activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3536 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3536 ZOBELLIA_3537 ZOBELLIA_3537 ZOBELLIA_3537 4089928 4091496 - Sulfatases%2C family S1-23 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 23%3B Signal peptide of lipoprotein cleaved between the residues 22 and 23%2C Localized in the outer membrane%3B~Family membership gene gene3537 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3537 ZOBELLIA_3538 ZOBELLIA_3538 ZOBELLIA_3538 4091507 4093120 - Sodium/glucose symporter Sodium/substrate symporter actively transports glucose into cells by Na+ cotransport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3538 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3538 ZOBELLIA_3539 ZOBELLIA_3539 ZOBELLIA_3539 4093122 4094084 - Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene3539 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3539 ZOBELLIA_354 ZOBELLIA_354 ZOBELLIA_354 470531 472396 - Fibronectin type-III repeats protein This conserved protein contains four type-III fibronectin (FN3) domains. Contains also a C-terminal domain of unknown function found in Fibrobacter succinogenes%2C Chlorobium tepidum and Bacteroides thetaiotaomicron. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_354 ZOBELLIA_3540 ZOBELLIA_3540 afcA6 afcA6 4094157 4096610 - Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Signal peptide cleaved between residues 25 and 26%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3540 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3540 ZOBELLIA_3541 ZOBELLIA_3541 ZOBELLIA_3541 4096849 4098300 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Probably localized in the outer membrane%3B~Family membership gene gene3541 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3541 ZOBELLIA_3542 ZOBELLIA_3542 ZOBELLIA_3542 4098343 4101585 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (32-105) and the Plug module (122-247) acting as a channel gate%3B The signal peptide is cleaved between the residues 26 and 27%3B~Family membership gene gene3542 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3542 ZOBELLIA_3543 ZOBELLIA_3543 ZOBELLIA_3543 4103359 4103463 + Putative protein Hypothetical protein gene gene3544 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3543 ZOBELLIA_3544 ZOBELLIA_3544 sdaA1 sdaA1 4101801 4103384 - L-serine dehydratase L-serine dehydratase is involved in the gluconeogenesis pathway. It catalyzes the deamination of serine to form pyruvate. It is activated by a post-translational modification via a system involving at least three gene products. There is considerable evidence for a free-radical activation mechanism%3B Binds a 4Fe-4S cluster as a cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3543 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3544 ZOBELLIA_3545 ZOBELLIA_3545 ZOBELLIA_3545 4103594 4104466 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3545 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3545 ZOBELLIA_3546 ZOBELLIA_3546 ZOBELLIA_3546 4104532 4105395 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3546 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3546 ZOBELLIA_3547 ZOBELLIA_3547 dppA2 dppA2 4105640 4107877 + Dipeptidyl-peptidase IV%2C family S9 Dipeptidyl-peptidase IV releases an N-terminal dipeptide%2C Xaa-Yaa-|-Zaa-%2C from a polypeptide%2C preferentially when Yaa is Pro%2C provided Zaa is neither Pro nor hydroxyproline. Belongs to the family S9 of the serine peptidases. The active site residues are in the order Ser%2C Asp%2C His in the sequence. The motif around the active site serine is G W S (Y/F) G G. DppA displays a two domain architecture%2C with a N-terminal eight-bladed beta-propeller and a C-terminal S9 peptidase domain. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm.%3B~High confidence in function and specificity gene gene3547 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3547 ZOBELLIA_3548 ZOBELLIA_3548 ZOBELLIA_3548 4108033 4109616 + Sulfatase%2C family S1-25 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 25%3B Contains an N-terminal transmembrane segment%3B Contains a N- terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3548 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3548 ZOBELLIA_3549 ZOBELLIA_3549 ZOBELLIA_3549 4109746 4111149 + Aminopeptidase%2C family M24 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. Belongs to the family M24 of the metallopeptidases. Requires two co-catalytic ions of manganese. Localized in the cytoplasm.%3B~Specificity unclear gene gene3549 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3549 ZOBELLIA_355 ZOBELLIA_355 ZOBELLIA_355 473111 475036 - Alpha-glucosidase%2C family GH97 Alpha-glucosidases catalyse the hydrolysis of terminal%2C non-reducing 1%2C4-linked alpha-D-glucose residues with release of alpha-D-glucose. Involved in carbohydrate metabolism%2C notably in starch degradation%3B Belongs to the family 97 of glycoside hydrolases (GH97)%3B Lipoprotein signal peptide cleaved between the residues 28 and 29%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_355 ZOBELLIA_3550 ZOBELLIA_3550 ZOBELLIA_3550 4111162 4111311 - Putative protein Hypothetical protein gene gene3550 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3550 ZOBELLIA_3551 ZOBELLIA_3551 ZOBELLIA_3551 4111379 4111927 - Conserved hypothetical periplasmic protein Protein conserved in the bacteria of the chlorobiaceae family%3B Signal peptide cleaved between the residues 21 and 22%3B Probably localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3551 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3551 ZOBELLIA_3552 ZOBELLIA_3552 ZOBELLIA_3552 4112110 4112547 - Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene3552 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3552 ZOBELLIA_3553 ZOBELLIA_3553 ZOBELLIA_3553 4113178 4114581 + Conserved hypothetical lipoprotein Protein that consists of two domains of unknown function DUF1080%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 28 and 29%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3553 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3553 ZOBELLIA_3554 ZOBELLIA_3554 ZOBELLIA_3554 4114584 4115912 + NAD(P)-dependent dehydrogenase%2C exported NAD(P)-dependent dehydrogenase. Belongs to the Rossmann fold family. Features a twin-arginine translocation signal peptide.%3B~Specificity unclear gene gene3554 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3554 ZOBELLIA_3555 ZOBELLIA_3555 ZOBELLIA_3555 4115958 4116149 + Putative protein Hypothetical protein gene gene3555 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3555 ZOBELLIA_3556 ZOBELLIA_3556 ZOBELLIA_3556 4116146 4117213 - LacI-type transcriptional regulator LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of catabolic%2C metabolic and transport operons%3B Contains a N-terminal LacI-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a C-terminal domain involved in the binding of inducers%3B Localized in the cytoplasm%3B~Family membership gene gene3556 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3556 ZOBELLIA_3557 ZOBELLIA_3557 ZOBELLIA_3557 4117444 4117905 - Hypothetical membrane protein Possible presence of an N-terminal transmembrane segment that would localize the protein in the cytoplasmic membrane%3B~Hypothetical protein gene gene3557 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3557 ZOBELLIA_3558 ZOBELLIA_3558 ZOBELLIA_3558 4118058 4118402 - Conserved hypothetical protein Probably localized in the cytoplasm gene gene3558 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3558 ZOBELLIA_3559 ZOBELLIA_3559 katA2 katA2 4118428 4120569 - Catalase This enzyme is a mono-functional haem-containing catalase that acts as an antioxidant enzyme catalyzing the conversion of hydrogen peroxide to water and molecular oxygen%2C serving to protect cells from its toxic effects. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3559 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3559 ZOBELLIA_356 ZOBELLIA_356 ZOBELLIA_356 475126 476721 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a Lipocalin signature involved in the transport of small hydrophobic molecules such as steroids%2C bilins%2C retinoids%2C and lipids%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~Family membership gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_356 ZOBELLIA_3560 ZOBELLIA_3560 ZOBELLIA_3560 4120627 4121040 - Hypothetical protein Probably localized in the cytoplasm gene gene3560 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3560 ZOBELLIA_3561 ZOBELLIA_3561 ZOBELLIA_3561 4121121 4121243 + Putative protein Hypothetical protein gene gene3561 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3561 ZOBELLIA_3562 ZOBELLIA_3562 ZOBELLIA_3562 4121343 4121747 + Conserved hypothetical protein Protein that consists of a glyoxalase/bleomycin resistance protein/dioxygenase domain. It also consists of a demethylubiquinone-9 3-methyltransferase domain that is superimposed on the precedent domain%3B localized in the cytoplasm gene gene3562 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3562 ZOBELLIA_3563 ZOBELLIA_3563 ZOBELLIA_3563 4121780 4122301 + Conserved hypothetical membrane protein Contains three N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3563 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3563 ZOBELLIA_3564 ZOBELLIA_3564 ZOBELLIA_3564 4122523 4122744 + Putative protein Hypothetical protein gene gene3564 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3564 ZOBELLIA_3565 ZOBELLIA_3565 ZOBELLIA_3565 4122865 4123314 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene3565 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3565 ZOBELLIA_3566 ZOBELLIA_3566 pldA pldA 4123376 4124224 - Phospholipase A1 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels. The active site His and Ser residues are located at the exterior of the beta-barrel%2C at the outer leaflet side of the membrane%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene3566 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3566 ZOBELLIA_3567 ZOBELLIA_3567 ZOBELLIA_3567 4124370 4125998 - Conserved hypothetical membrane protein Contains four N-terminal tetratricopeptide repeats (TPR) involved in protein-protein interactions and the assembly of multiprotein complexes%2C and a C-terminal LuxR-type HTH domain. These two domains are separated by a transmembrane segement%3B This Protein could interact with the DNA (transcriptional control or transcription factor)%3B localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3567 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3567 ZOBELLIA_3568 ZOBELLIA_3568 fucA4 fucA4 4126495 4128018 + Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 19 and 20%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3568 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3568 ZOBELLIA_3569 ZOBELLIA_3569 ZOBELLIA_3569 4128398 4128586 - Putative protein Hypothetical protein gene gene3569 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3569 ZOBELLIA_357 ZOBELLIA_357 ZOBELLIA_357 476734 480243 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension that probably interacts with an anti-sigma factor (Secretin/TonB (STN) domain)%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (146-220) and a Plug module (236-371) acting as the channel gate%3B The signal peptide is cleaved between the residue 27 and 28%3B~Family membership gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_357 ZOBELLIA_3570 ZOBELLIA_3570 ZOBELLIA_3570 4128951 4132034 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly oligoagaroses) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (32-104) and the Plug module (120-227) acting as a channel gate%3B The signal peptide is cleaved between the residues 28 and 29%3B~Family membership gene gene3570 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3570 ZOBELLIA_3571 ZOBELLIA_3571 ZOBELLIA_3571 4132091 4133857 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 21 and 22%3B Putatively localized in the outer membrane%3B~Family membership gene gene3571 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3571 ZOBELLIA_3572 ZOBELLIA_3572 ZOBELLIA_3572 4133892 4135535 + Conserved lipoprotein containing CBM22 Conserved lipoprotein containing a N-terminal domain of unknown function and a C-terminal Carbohydrate Binding Module of family 22 (CBM22)%3B Signal peptide cleaved between the residues 28 and 29%3B localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3572 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3572 ZOBELLIA_3573 ZOBELLIA_3573 agaB agaB 4135622 4136683 + Beta-agarase B%2C family GH16 The beta-agarase B hydrolyses the 1%2C4-beta-D-galactosidic linkages in agarose%2C giving the tetramer and the dimer as the predominant products%3B Acts on agarose as a homodimer%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide of lipoprotein cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene3573 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3573 ZOBELLIA_3574 ZOBELLIA_3574 cbpA cbpA 4136952 4137857 + Co-chaperone protein CbpA CbpA is a DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of dnaJ%3B displays overlapping activities with dnaJ%2C but functions under different conditions%2C probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity%3B binds native substrates and targets them for recognition by dnaK%3B Contains an N-terminal J domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3574 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3574 ZOBELLIA_3575 ZOBELLIA_3575 ZOBELLIA_3575 4137862 4138152 + Conserved hypothetical protein Possibly localized in the cytoplasm gene gene3575 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3575 ZOBELLIA_3576 ZOBELLIA_3576 ZOBELLIA_3576 4138189 4138581 - AraC-type HTH domain The AraC-type HTH domain found in the sequence%2C encompasses more than 75%25 of the length sequence%3B~Family membership gene gene3576 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3576 ZOBELLIA_3577 ZOBELLIA_3577 sgsA7 sgsA7 4138933 4140801 + N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3577 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3577 ZOBELLIA_3578 ZOBELLIA_3578 ZOBELLIA_3578 4141037 4142881 + Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Family membership gene gene3578 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3578 ZOBELLIA_3579 ZOBELLIA_3579 ZOBELLIA_3579 4143075 4143194 - Conserved hypothetical protein Peptide Putatively localized in the cytoplasm gene gene3579 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3579 ZOBELLIA_358 ZOBELLIA_358 ZOBELLIA_358 480420 481460 - anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_358 ZOBELLIA_3580 ZOBELLIA_3580 ZOBELLIA_3580 4143222 4144973 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 24 and 25%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B~Family membership gene gene3580 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3580 ZOBELLIA_3581 ZOBELLIA_3581 ZOBELLIA_3581 4144984 4148214 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (58-131) and the Plug module (147-263) acting as a channel gate%3B The signal peptide is cleaved between the residues 38 and 39%3B~Family membership gene gene3581 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3581 ZOBELLIA_3582 ZOBELLIA_3582 ZOBELLIA_3582 4148507 4148599 + Putative protein Hypothetical protein gene gene3582 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3582 ZOBELLIA_3583 ZOBELLIA_3583 ZOBELLIA_3583 4148740 4149147 - Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene3583 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3583 ZOBELLIA_3584 ZOBELLIA_3584 ZOBELLIA_3584 4149157 4151742 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene3584 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3584 ZOBELLIA_3585 ZOBELLIA_3585 ZOBELLIA_3585 4151860 4151955 - Putative protein Hypothetical protein gene gene3585 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3585 ZOBELLIA_3586 ZOBELLIA_3586 ZOBELLIA_3586 4151994 4152116 - Helix-turn-helix%2C AraC type Protein that consists of an Helix-turn-helix%2C AraC type%3B This motif is found in various transcriptional regulators and situated towards the C-terminus in the third quarter of most of the sequences%3B~Function unclear gene gene3586 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3586 ZOBELLIA_3587 ZOBELLIA_3587 ZOBELLIA_3587 4152400 4153488 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Possibly localized in the cytoplasm%3B~Family membership gene gene3587 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3587 ZOBELLIA_3588 ZOBELLIA_3588 ZOBELLIA_3588 4153491 4154819 + Sigma-54 dependent two-component system-Response regulator These response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes%2C activating the expression of genes from promoters recognized by core RNA polymerase associated with the alternative sigma-54 factor. These proteins consist of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C a motif that interacts with the sigma 54 factor and a C-terminal Fis-type HTH motif%3B~Family membership gene gene3588 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3588 ZOBELLIA_3589 ZOBELLIA_3589 ZOBELLIA_3589 4154959 4155447 + GreA-like transcription elongation factor Conserved protein belonging to the GreA family of the transcription elongation factors. Localized in the cytoplasm.%3B~Specificity unclear gene gene3589 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3589 ZOBELLIA_359 ZOBELLIA_359 ZOBELLIA_359 481788 482366 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_359 ZOBELLIA_3590 ZOBELLIA_3590 ZOBELLIA_3590 4155482 4155844 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 17 and 18%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3590 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3590 ZOBELLIA_3591 ZOBELLIA_3591 gdhA2 gdhA2 4156163 4157455 + Glutamate dehydrogenase Glutamate dehydrogenase catalyzes the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate. It is involved with either ammonia assimilation or glutamate catabolism. Forms a homohexamer and binds one NAD(P) cofactor by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3591 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3591 ZOBELLIA_3592 ZOBELLIA_3592 rnkA rnkA 4157467 4157883 + Regulator of nucleoside diphosphate kinase Rnk regulates the level of nucleoside diphosphate kinase. It belongs to the GreA family of elongation transcription factor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3592 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3592 ZOBELLIA_3593 ZOBELLIA_3593 ZOBELLIA_3593 4158067 4159218 - 3-carboxymuconate cyclase-like protein Possible 3-carboxymuconate cyclase%2C which converts by isomerisation the 3-carboxy-2%2C5-dihydro-5-oxofuran-2-acetate to 3-carboxy-cis%2Ccis-muconate%3B Contains a signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Belongs to the cycloisomerase 2 family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3593 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3593 ZOBELLIA_3594 ZOBELLIA_3594 ZOBELLIA_3594 4159237 4161180 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3594 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3594 ZOBELLIA_3595 ZOBELLIA_3595 mdsA5 mdsA5 4161211 4162698 - Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3595 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3595 ZOBELLIA_3596 ZOBELLIA_3596 ZOBELLIA_3596 4162747 4164198 - Sulfatase%2C family S1-14 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 14%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Family membership gene gene3596 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3596 ZOBELLIA_3597 ZOBELLIA_3597 ZOBELLIA_3597 4164380 4165681 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3597 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3597 ZOBELLIA_3598 ZOBELLIA_3598 ZOBELLIA_3598 4165727 4166881 - Conserved hypothetical lipoprotein Contains a putative lipoprotein signal peptide cleaved betweenthe residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3598 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3598 ZOBELLIA_3599 ZOBELLIA_3599 ZOBELLIA_3599 4166957 4170016 - Glycoside hydrolase%2C family GH2 Modular enzyme with a N-terminal beta-galactosidase domain (belongs to the family 2 of glycoside hydrolases%2C TIM alpha/beta barrel fold) and two C-terminal fibronectin type III domain (FN3)%3B Seems to have a signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the periplasmic space%3B~Family membership gene gene3599 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3599 ZOBELLIA_36 ZOBELLIA_36 ZOBELLIA_36 36809 37507 - Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_36 ZOBELLIA_360 ZOBELLIA_360 ZOBELLIA_360 482372 485698 - Conserved hypothetical protein Contains four tetratrico peptide repeats (TPRs). The TPR motif consists of 316 tandem-repeats of 34 amino acids residues. It adopts a helixturnhelix arrangement%2C with adjacent TPR motifs packing in a parallel fashion%2C resulting in a spiral of repeating anti-parallel alpha-helices. TPRs mediate proteinprotein interactions%3B Localized in the cytoplasm. gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_360 ZOBELLIA_3600 ZOBELLIA_3600 sgsA8 sgsA8 4170028 4171467 - N-sulfoglucosamine sulfohydrolase%2C family S1-8 The N-sulfoglucosamine sulfohydrolase%2C called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 8%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3600 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3600 ZOBELLIA_3601 ZOBELLIA_3601 ZOBELLIA_3601 4171506 4173797 - Glycoside hydrolase%2C family GH2 The family 2 of glycoside Hydrolase (GH2%2C TIM alpha/beta barrel fold) contains the activities beta-galactosidase%2C beta-mannosidase%2C beta-glucuronidase and exo-beta-glucosaminidase%3B Signal peptide of lipoprotein cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Family membership gene gene3601 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3601 ZOBELLIA_3602 ZOBELLIA_3602 ZOBELLIA_3602 4173807 4175759 - Alpha-glucosidase%2C family GH97 Alpha-glucosidases catalyse the hydrolysis of terminal%2C non-reducing 1%2C4-linked alpha-D-glucose residues with release of alpha-D-glucose. Involved in carbohydrate metabolism%2C notably in starch degradation%3B Belongs to the family 97 of glycoside hydrolases (GH97)%3B Lipoprotein signal peptide cleaved between the residues 20 and 21%3B Probably localized in the outer membrane%3B~High confidence in function and specificity gene gene3602 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3602 ZOBELLIA_3603 ZOBELLIA_3603 ZOBELLIA_3603 4175776 4176660 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3603 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3603 ZOBELLIA_3604 ZOBELLIA_3604 ZOBELLIA_3604 4176677 4178968 - Possible FAD dependent oxidoreductase Contains a N-terminal flavoprotein domain (20 to 426)%3B Belongs to the FAD/NAD(P)-binding Rossmann fold Superfamily%2C pyridine nucleotide-disulfide oxidoreductase family%3B Localized in the cytoplasm%3B~Family membership gene gene3604 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3604 ZOBELLIA_3605 ZOBELLIA_3605 ZOBELLIA_3605 4179034 4180692 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains 15 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3605 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3605 ZOBELLIA_3606 ZOBELLIA_3606 ZOBELLIA_3606 4180803 4182611 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Family membership gene gene3606 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3606 ZOBELLIA_3607 ZOBELLIA_3607 ZOBELLIA_3607 4182630 4185737 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (22-95) and the Plug module (111-220) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene3607 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3607 ZOBELLIA_3608 ZOBELLIA_3608 ZOBELLIA_3608 4186000 4186110 - Putative protein Hypothetical protein gene gene3608 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3608 ZOBELLIA_3609 ZOBELLIA_3609 ZOBELLIA_3609 4186124 4187140 + GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA. At the C-terminus there is an effector- binding/oligomerisation domain%3B Localized in the cytoplasm%3B~Family membership gene gene3609 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3609 ZOBELLIA_361 ZOBELLIA_361 ZOBELLIA_361 485733 485828 - Putative protein Hypothetical protein gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_361 ZOBELLIA_3610 ZOBELLIA_3610 cstA cstA 4187149 4188591 - Carbon starvation protein A CstA is induced during carbon starvation and is positively regulated by the cyclic AMP (cAMP) and cAMP receptor protein complex. It is involved in peptide utilization%3B Contains 13 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3610 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3610 ZOBELLIA_3611 ZOBELLIA_3611 ZOBELLIA_3611 4188615 4189733 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3611 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3611 ZOBELLIA_3612 ZOBELLIA_3612 ZOBELLIA_3612 4189730 4191523 - Possible FAD dependent oxidoreductase Contains a C-terminal flavoprotein domain (206 to 593)%3B Belongs to the FAD/NAD(P)-binding Rossmann fold Superfamily%2C pyridine nucleotide-disulfide oxidoreductase family%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Family membership gene gene3612 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3612 ZOBELLIA_3613 ZOBELLIA_3613 bgaA bgaA 4191767 4194682 - Beta-galactosidase%2C family GH2 Enzyme belonging to the family 2 of glycoside hydrolases (GH2) which catalyzes the hydrolysis of the beta-1%2C4 linkage at the terminal non-reducing of beta-D-galactosides%2C releasing a beta-D-galactose residue%3B Possesses a putative C-terminal carbohydrate module (CBM6)%3B Signal peptide cleaved between residues 19 and 20%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3613 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3613 ZOBELLIA_3614 ZOBELLIA_3614 ZOBELLIA_3614 4194718 4196979 - Cytochrome c-containing protein Large conserved protein containing a C-terminal cytochrome c. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B Contains a putative lipoprotein signal peptide cleaved between the residues 31 and 32%3B Possibly localized in the outer membrane%3B~Family membership gene gene3614 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3614 ZOBELLIA_3615 ZOBELLIA_3615 ZOBELLIA_3615 4197022 4198266 - conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3615 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3615 ZOBELLIA_3616 ZOBELLIA_3616 alfA6 alfA6 4198287 4199708 - Alpha-L-fucosidase%2C family GH29 Modular protein that consists of an N-terminal alpha-L-fucosidase module belonging to the family 29 of glycoside hydrolases (GH29)%2C responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside and a C-terminal domain that could be involved in the binding to specific ligands such as carbohydrate or lipids substrates%3B Signal peptide cleaved between the residue 19 and 20%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3616 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3616 ZOBELLIA_3617 ZOBELLIA_3617 fucA5 fucA5 4199717 4201096 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 23 and 24%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3617 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3617 ZOBELLIA_3618 ZOBELLIA_3618 ZOBELLIA_3618 4201140 4202627 - Sulfatase%2C family S1-15 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 15%3B Signal petide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Family membership gene gene3618 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3618 ZOBELLIA_3619 ZOBELLIA_3619 ZOBELLIA_3619 4202686 4202784 - Putative protein Hypothetical protein gene gene3619 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3619 ZOBELLIA_362 ZOBELLIA_362 ZOBELLIA_362 485942 486784 + AraC-type transcriptional regulators The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_362 ZOBELLIA_3620 ZOBELLIA_3620 ZOBELLIA_3620 4202848 4204521 - Hypothetical protein This protein likely adopts a right handed parallel beta-helix fold%3B Signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space gene gene3620 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3620 ZOBELLIA_3621 ZOBELLIA_3621 ZOBELLIA_3621 4204702 4207182 - Fibronectin type-III repeats protein This conserved protein contains two N-terminal type-III fibronectin domains and a C-terminal domain of unknown function%3B Signal peptide cleaved between the residues 33 and 34%3B Localized in the periplasmic space%3B~Family membership gene gene3621 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3621 ZOBELLIA_3622 ZOBELLIA_3622 fucA6 fucA6 4207229 4208761 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 27 and 28%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3622 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3622 ZOBELLIA_3623 ZOBELLIA_3623 ZOBELLIA_3623 4208758 4210416 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3623 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3623 ZOBELLIA_3624 ZOBELLIA_3624 ZOBELLIA_3624 4210437 4213091 - Conserved hypothetical protein This protein displays distant similarity with glycoside hydrolases of the family 74 (GH74). These proteins consist of a tandem repeat of two similar domains%2C which are both folded into seven-bladed beta- propeller structures. But the two conserved catalytic aspartatic residues are substituted here by two asparagine residues. Features a signal peptide cleaved between the residues 19 and 20. gene gene3624 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3624 ZOBELLIA_3625 ZOBELLIA_3625 ZOBELLIA_3625 4213092 4213916 - Carbohydrate esterase%2C family CE4 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 4 of carbohydrate esterases (CE4). These proteins fold into a 7-stranded beta/alpha barrel%3B Signal peptide cleaved between residues 20 and 21%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3625 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3625 ZOBELLIA_3626 ZOBELLIA_3626 ZOBELLIA_3626 4213920 4214918 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3626 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3626 ZOBELLIA_3627 ZOBELLIA_3627 ZOBELLIA_3627 4214937 4217567 - Glycoside hydrolase%2C family GH74 This enzyme belongs to the family 74 of the glycoside hydrolases. These proteins consist of a tandem repeat of two similar domains%2C which are both folded into seven-bladed beta-propeller structures. The conserved catalytic residues are Asp70 and Asp 549. Features a signal peptide cleaved between the residues 24 and 25.%3B~Specificity unclear gene gene3627 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3627 ZOBELLIA_3628 ZOBELLIA_3628 porD porD 4217601 4218884 - Beta-porphyranase D%2C family GH16 The beta-porphyranases hydrolyse the 1%2C4-beta-D-galactosidic linkages in porphyrans%3B Contains a C-terminal domain of unknown function%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3628 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3628 ZOBELLIA_3629 ZOBELLIA_3629 ZOBELLIA_3629 4218897 4220513 - Sulfatase%2C family S1-30 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 30%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Family membership gene gene3629 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3629 ZOBELLIA_363 ZOBELLIA_363 ZOBELLIA_363 487749 490580 + Ligand-binding sensor protein Protein that consists of an N-terminal periplasmic beta-propeller followed by a C-terminal cytoplasmic domain containing a LuxR-type HTH domain acting as transcrptionnal regulator. A transmembrane segment is present between these two domains. Signal peptide cleaved between the residues 28 and 29%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_363 ZOBELLIA_3630 ZOBELLIA_3630 ZOBELLIA_3630 4220551 4222119 - Sulfatase%2C family S1-28 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 28%3B Signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Family membership gene gene3630 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3630 ZOBELLIA_3631 ZOBELLIA_3631 ZOBELLIA_3631 4222124 4223512 - Polygalacturonase%2C family GH28 The polygalacturonases catalyze the random hydrolysis of 1%2C4-alpha-D-galactosiduronic linkages in pectate and other galacturonans%3B The tertiary structures show a stack of parallel beta strands that are coiled into a large helix%3B Belongs to the family 28 of glycoside hydrolases (GH28)%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Specificity unclear gene gene3631 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3631 ZOBELLIA_3632 ZOBELLIA_3632 ZOBELLIA_3632 4223514 4224917 - Polygalacturonase%2C family GH28 The polygalacturonases catalyze the random hydrolysis of 1%2C4-alpha-D-galactosiduronic linkages in pectate and other galacturonans%3B The tertiary structures show a stack of parallel beta strands that are coiled into a large helix%3B Belongs to the family 28 of glycoside hydrolases (GH28)%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane and possibly secreted%3B~Specificity unclear gene gene3632 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3632 ZOBELLIA_3633 ZOBELLIA_3633 bgaB bgaB 4224923 4227400 - Beta-galactosidase%2C family GH2 Enzyme belonging to the family 2 of glycoside hydrolases (GH2) which catalyzes the hydrolysis of the beta-1%2C4 linkage at the terminal non-reducing of beta-D-galactosides%2C releasing a beta-D-galactose residue%3B Signal peptide cleaved between residues 20 and 21%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3633 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3633 ZOBELLIA_3634 ZOBELLIA_3634 fucA7 fucA7 4227761 4229317 + Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide of lipoprotein cleaved between the residue 18 and 19%3B Localized in outer membrane%3B~High confidence in function and specificity gene gene3634 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3634 ZOBELLIA_3635 ZOBELLIA_3635 ZOBELLIA_3635 4229527 4231044 - Sulfatase%2C family S1-28 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 28%3B Putative lipoprotein with a signal peptide cleaved between the residues 15 and 16%3B Possibly localized in the outer membrane%3B~Family membership gene gene3635 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3635 ZOBELLIA_3636 ZOBELLIA_3636 ZOBELLIA_3636 4231212 4235453 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3636 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3636 ZOBELLIA_3637 ZOBELLIA_3637 ZOBELLIA_3637 4235954 4239133 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here%2C possibly oligoagarose) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (32-104) and the Plug module (120-228) acting as a channel gate%3B The signal peptide is cleaved between the residues 29 and 30%3B~Family membership gene gene3637 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3637 ZOBELLIA_3638 ZOBELLIA_3638 ZOBELLIA_3638 4239145 4241055 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 31 and 32%3B Putatively localized in the outer membrane but the determination of the membrane identity for the protein localization is not clear%3B~Family membership gene gene3638 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3638 ZOBELLIA_3639 ZOBELLIA_3639 ZOBELLIA_3639 4241076 4243079 + Conserved lipoprotein containing CBM22 Conserved protein containing a N-terminal domain of unknown function and a C-terminal Carbohydrate Binding Module of family 22. lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Specificity unclear gene gene3639 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3639 ZOBELLIA_364 ZOBELLIA_364 ZOBELLIA_364 490884 493958 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (31-104) and the Plug module (120-230) acting as a channel gate%3B The signal peptide is cleaved between the residues 27 and 28%3B~Family membership gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_364 ZOBELLIA_3640 ZOBELLIA_3640 porE porE 4243182 4244021 + Beta-porphyranase E%2C family GH16 The beta-porphyranases hydrolyse the 1%2C4-beta-D-galactosidic linkages in porphyrans%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3640 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3640 ZOBELLIA_3641 ZOBELLIA_3641 mroA3 mroA3 4244029 4245132 - Aldose 1-epimerase Aldose 1-epimerase or Mutarotase is responsible for the anomeric interconversion of aldoses between their alpha- and beta-forms%3B It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose%3B Signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~High confidence in function and specificity gene gene3641 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3641 ZOBELLIA_3642 ZOBELLIA_3642 ZOBELLIA_3642 4245194 4246885 - Sulfatase%2C family S1-25 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 25%3B Signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space%3B~Family membership gene gene3642 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3642 ZOBELLIA_3643 ZOBELLIA_3643 ZOBELLIA_3643 4246919 4248310 - Sulfatase%2C family S1-19 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 19%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Family membership gene gene3643 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3643 ZOBELLIA_3644 ZOBELLIA_3644 fucA8 fucA8 4248325 4249833 - Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide cleaved between the residue 18 and 19%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3644 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3644 ZOBELLIA_3645 ZOBELLIA_3645 ZOBELLIA_3645 4249862 4250611 - Conserved hypothetical protein Conserved protein belonging to the DUF1080 family. Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space gene gene3645 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3645 ZOBELLIA_3646 ZOBELLIA_3646 thiD thiD 4250918 4251715 - Phosphomethylpyrimidine kinase Phosphomethylpyrimidine kinase also known as HMP(Hydroxymethylpyrimidine)-phosphate kinase catalyzes the phosphorylation of HMP-P to HMP-PP during the biosynthesis of thiamine%3B It is part of the Thiamine pyrophosphate (TPP) synthesis pathway%2C TPP is an essential cofactor for many enzymes%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3646 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3646 ZOBELLIA_3647 ZOBELLIA_3647 ZOBELLIA_3647 4252193 4263760 + Hypothetical protein Would contain ten type-3 Thrombospondin repeats%3B Signal peptide cleaved between the residues 24 and 25%3B Putatively localized in the outer membrane gene gene3647 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3647 ZOBELLIA_3648 ZOBELLIA_3648 ZOBELLIA_3648 4263786 4264718 + Conserved hypothetical protein Conserved hypothetical protein%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space gene gene3648 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3648 ZOBELLIA_3649 ZOBELLIA_3649 ZOBELLIA_3649 4264728 4266668 + OmpA-like periplasmic protein This protein has a modular architecture with a N-terminal TPR motif%2C a central beta-propeller domain%2C encompassing three WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 20 and 21%3B localized in the periplasmic space and/or in the outer membrane%3B~Family membership gene gene3649 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3649 ZOBELLIA_365 ZOBELLIA_365 ZOBELLIA_365 493972 495576 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding. This sequence corresponds to the N-terminal domain found in the proteins belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 25 and 26%3B Probably localized in the outer membrane%3B~Family membership gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_365 ZOBELLIA_3650 ZOBELLIA_3650 ZOBELLIA_3650 4267518 4281656 + Conserved hypothetical protein Contains a N-terminal DUF 11 domain. Protein that would bind calcium ions by several EF-hand calcium-binding domains or/and by trombospondin type III domains%3B Signal peptide cleaved between the residues 27 and 28%3B Putatively localized in the outer membrane gene gene3650 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3650 ZOBELLIA_3651 ZOBELLIA_3651 ZOBELLIA_3651 4281683 4282615 + Conserved hypothetical membrane protein Contains an uncleavable signal peptide. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene3651 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3651 ZOBELLIA_3652 ZOBELLIA_3652 ZOBELLIA_3652 4282626 4284563 + OmpA-like periplasmic protein This protein has a modular architecture with a N-terminal TPR motif%2C a central beta-propeller domain%2C encompassing three WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan. The tetratrico peptide repeat (TPR) is a structural motif%2C which mediates proteinprotein interactions%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane and/or periplasmic space%3B~Family membership gene gene3652 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3652 ZOBELLIA_3653 ZOBELLIA_3653 thiS thiS 4284964 4285167 + Sulfur transfer protein ThiS ThiS is involved in sulphur transfer during the thiamine biosynthesis pathway. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS%3B Contains two conserved glycines at the C-terminus%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3653 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3653 ZOBELLIA_3654 ZOBELLIA_3654 thiC thiC 4285275 4287134 + Thiamine biosynthesis protein ThiC ThiC is involved in thiamine biosynthesis%2C but its precise catalytic function is still unknown. It is required for the synthesis of the hydromethylpyrimidine moiety of thiamine (4-amino-2-methyl-5- hydroxymethylpyrimidine). Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3654 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3654 ZOBELLIA_3655 ZOBELLIA_3655 ZOBELLIA_3655 4287145 4287777 + Thiamine-phosphate synthase-like protein Conserved protein distantly related to Thiamine-phosphate synthase (ThiE)%3B Localized in the cytoplasm%3B~Function unclear gene gene3655 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3655 ZOBELLIA_3656 ZOBELLIA_3656 thiE thiE 4287783 4288436 + Thiamine-phosphate pyrophosphorylase Thiamine-phosphate pyrophosphorylase (or Thiamine monophosphate synthase) is involved in thiamine biosynthesis. It catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5-hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate. It binds one magnesium ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3656 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3656 ZOBELLIA_3657 ZOBELLIA_3657 thiG thiG 4288439 4289209 + Thiazole biosynthesis protein ThiG The protein ThiG is required for the synthesis of the thiazole moiety of thiamine (vitamin B1)%3B Binds FMN as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3657 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3657 ZOBELLIA_3658 ZOBELLIA_3658 thiH thiH 4289220 4290326 + Thiamine biosynthesis protein ThiH The protein ThiH is required for the synthesis of the thiazole moiety of thiamine (vitamin B1)%3B Binds one 4Fe-4S cluster%2C which is coordinated with three cysteines and an exchangeable S-adenosyl-L-methionine%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3658 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3658 ZOBELLIA_3659 ZOBELLIA_3659 rluC rluC 4290347 4291159 - Ribosomal large subunit pseudouridine synthase C Enzyme responsible for synthesis of pseudouridine from uracil at positions 955%2C 2504 and 2580 in 23S ribosomal RNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Contains a N-terminal S4 RNA- binding domain that probably mediates binding to RNA%3B Belongs to the pseudouridine synthase RluA family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene3659 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3659 ZOBELLIA_366 ZOBELLIA_366 ZOBELLIA_366 495668 496450 + Glycerophosphoryl diester phosphodiesterase Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols%3B Signal peptide of lipoprotein cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_366 ZOBELLIA_3660 ZOBELLIA_3660 ZOBELLIA_3660 4291299 4292063 - Conserved hypothetical membrane protein Conserved protein belonging to the DUF1275 family%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3660 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3660 ZOBELLIA_3661 ZOBELLIA_3661 ZOBELLIA_3661 4292215 4292307 + Putative protein Hypothetical protein gene gene3661 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3661 ZOBELLIA_3662 ZOBELLIA_3662 ZOBELLIA_3662 4292539 4292958 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene3662 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3662 ZOBELLIA_3663 ZOBELLIA_3663 ZOBELLIA_3663 4292992 4293519 - Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3663 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3663 ZOBELLIA_3664 ZOBELLIA_3664 ZOBELLIA_3664 4293739 4294968 + TPR repeats protein Conserved protein containing a N-terminal domain of unknown function and six C-terminal tetratrico peptide repeats. TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Function unclear gene gene3664 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3664 ZOBELLIA_3665 ZOBELLIA_3665 ZOBELLIA_3665 4295074 4295700 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3665 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3665 ZOBELLIA_3666 ZOBELLIA_3666 ZOBELLIA_3666 4295703 4296437 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C which acts as transcriptional regulator. Localized in the cytoplasm.%3B~Specificity unclear gene gene3666 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3666 ZOBELLIA_3667 ZOBELLIA_3667 ZOBELLIA_3667 4296655 4298787 - Conserved hypothetical protein Localized in the cytoplasm gene gene3667 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3667 ZOBELLIA_3668 ZOBELLIA_3668 aroE aroE 4298978 4299718 - Shikimate dehydrogenase Shikimate dehydrogenase catalyzes the fourth step of The shikimate pathway. In a NADP+-dependent reaction%2C AroE converts the shikimate to 3-dehydroshikimate. The N-terminal domain is the shikimate-binding domain and consists of a mainly parallel six-stranded beta-sheet and six alpha-helices. The C-terminal NADP-binding domain adopts a nearly canonical Rossmann fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3668 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3668 ZOBELLIA_3669 ZOBELLIA_3669 ZOBELLIA_3669 4299750 4300778 - Conserved hypothetical membrane protein Conserved protein belonging to the DUF368 family%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3669 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3669 ZOBELLIA_367 ZOBELLIA_367 lamB lamB 496534 497424 + Endo-1%2C3-beta-glucanase%2C family GH16 Endo-1%2C3-beta-glucanase (Laminarinase) hydrolyzes the 1%2C3-beta-D-glucosidic linkages in 1%2C3-beta-D-glucans. Belongs to the family 16 of glycoside hydrolases (GH16). Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_367 ZOBELLIA_3670 ZOBELLIA_3670 ZOBELLIA_3670 4300789 4301703 - Conserved hypothetical membrane protein Conserved protein belonging to the DUF368 family%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene3670 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3670 ZOBELLIA_3671 ZOBELLIA_3671 ZOBELLIA_3671 4301819 4303219 - TPR repeats protein Conserved protein containing ten tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Localized in the cytoplasm%3B~Function unclear gene gene3671 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3671 ZOBELLIA_3672 ZOBELLIA_3672 ZOBELLIA_3672 4303317 4304498 - Acetylornithine aminotransferase Acetylornithine aminotransferase is involved in the Urea cycle and metabolism of amino groups. It catalyzes the transfer of an amino group from acetylornithine to alpha-ketoglutarate%2C yielding N-acetyl-glutamic-5-semi-aldehyde and glutamic acid%3B Uses the Pyridoxal phosphate as cofactor linked to a conserved lysine residue%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3672 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3672 ZOBELLIA_3673 ZOBELLIA_3673 ZOBELLIA_3673 4304495 4306237 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3673 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3673 ZOBELLIA_3674 ZOBELLIA_3674 purA purA 4306403 4307674 - Adenylosuccinate synthase Adenylosuccinate synthetase plays an important role in purine biosynthesis%2C by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. It forms a homodimer and binds one magnesium ion per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3674 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3674 ZOBELLIA_3675 ZOBELLIA_3675 furA1 furA1 4307687 4308142 - Ferric uptake regulation protein Ferric uptake regulation protein is a transcriptional regulator that acts as a global negative controlling element%2C employing Fe(2+) as a cofactor to bind the operator of the repressed metal ion-responsive genes. It regulates the expression of several outer- membrane proteins including the iron transport operon%3B Contains a N-terminal Fur-type HTH DNA-binding domain%3B Belongs to the Fur family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3675 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3675 ZOBELLIA_3676 ZOBELLIA_3676 relA relA 4308197 4310401 - GTP pyrophosphokinase GTP pyrophosphokinase catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. The ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance%3B Contains a HD domain involved in the coordination of divalent cations%2C a TGS domain that could play a nucleotide-binding and regulatory role and a C-terminal ACT domain%3B Belongs to the relA/spoT family%3B Localized in the cytoplasm%3B%2C Contains .%2C%3B~High confidence in function and specificity gene gene3676 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3676 ZOBELLIA_3677 ZOBELLIA_3677 ZOBELLIA_3677 4310506 4311732 - CAAX prenyl protease 1 CAAX prenyl protease 1 proteolytically removes the C-terminal three residues of farnesylated proteins%2C Subsequently%2C the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane-anchor%3B Binds 1 zinc ion per subunit%3B Contains seven transmembrane segments%3B Belongs to the peptidase M48A family (Ste24 endopeptidase family)%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3677 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3677 ZOBELLIA_3678 ZOBELLIA_3678 ZOBELLIA_3678 4311787 4312599 - tRNA/rRNA methyltransferase Catalyzes the site-specific methylation of the 2' hydroxy group of the ribose in rRNA or tRNA%2C using the S-AdoMet%3B Contains a N-terminal RNA 2'-O ribose methyltransferase substrate binding domain and a C-terminal catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold%3B Belongs to the RNA methyltransferase TrmH family%3B Localized in the cytoplasm%3B~Family membership gene gene3678 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3678 ZOBELLIA_3679 ZOBELLIA_3679 ZOBELLIA_3679 4312661 4313461 + Conserved hypothetical lipoprotein Contains a lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3679 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3679 ZOBELLIA_368 ZOBELLIA_368 susB susB 497815 499938 - Alpha-glucosidase%2C family GH97 The Sus (starch utilization system) proteins are involved in the starch catabolism%3B The SusB protein is an alpha-glucosidase that hydrolyzes the alpha-1%2C4 linkages of maltose and maltotriose and the alpha-1%2C4 and alpha-1%2C6 linkages of the panose%3B It belongs to the family 97 of glycoside hydrolases%3B Signal peptide cleaved between the residue 24 and 25%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene368 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_368 ZOBELLIA_3680 ZOBELLIA_3680 moaE1 moaE1 4313763 4314173 + Molybdopterin synthase%2C large subunit Molybdopterin synthase converts molybdopterin precursor Z into molybdopterin in the second major step of the molybdenum cofactor biosynthesis. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group responsible for molybdenum ligation%3B The enzyme is a heterodimer of 2 small (moaD) subunits and 2 large (moaE) subunits%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3680 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3680 ZOBELLIA_3681 ZOBELLIA_3681 moaA moaA 4314252 4315235 + Molybdenum cofactor biosynthesis protein A Together with moaC%2C is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z%3B Binds 2 4Fe-4S clusters: 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate%3B Contains an N-terminal SAM domain%3B Belongs to the radical SAM superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3681 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3681 ZOBELLIA_3682 ZOBELLIA_3682 moaC moaC 4315240 4315713 + Molybdenum cofactor biosynthesis protein C Involved in molybdenum cofactor biosynthesis%2C MoaC%2C a small hexameric protein%2C converts%2C together with MoaA%2C a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms%2C which is the first of three phases of molybdenum cofactor biosynthesis%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3682 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3682 ZOBELLIA_3683 ZOBELLIA_3683 mobA mobA 4315697 4316293 + Molybdopterin-guanine dinucleotide biosynthesis protein A Links a guanosine 5'-phosphate to molydopterin forming molybdopterin guanine dinucleotide (MGD)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3683 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3683 ZOBELLIA_3684 ZOBELLIA_3684 moeB moeB 4316290 4317363 + Molybdopterin synthase activating protein Enzyme involved in the biosynthesis of molybdopterin cofactor%2C necessary for molybdoenzymes. Plays a role in the activation of the small subunit of the molybdopterin converting factor (moaD)%3B Contains a N- terminal transmembrane segment and a C-terminal rhodanese domain%3B Belongs to the hesA/moeB/thiF family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3684 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3684 ZOBELLIA_3685 ZOBELLIA_3685 ZOBELLIA_3685 4317347 4318123 + Permease Permease without known function%3B Contains seven transmembranne segments%3B Belongs to the DUF81 family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3685 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3685 ZOBELLIA_3686 ZOBELLIA_3686 ZOBELLIA_3686 4318151 4318783 + Conserved hypothetical protein Protein that consists of a WbqC-like domain functionally uncharacterised%3B Could belong to the WbqC-like protein family%3B Localized in the cytoplasm gene gene3686 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3686 ZOBELLIA_3687 ZOBELLIA_3687 ZOBELLIA_3687 4318776 4319096 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3687 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3687 ZOBELLIA_3688 ZOBELLIA_3688 ZOBELLIA_3688 4319076 4320101 - Endonuclease/exonuclease/phosphatase family The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling%3B Contains two N-terminal transmembrane segments%3B Belongs to the Endonuclease/Exonuclease/ phosphatase family%3B Possible signal peptide of lipoprotein cleaved between the residues 25 and 26%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3688 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3688 ZOBELLIA_3689 ZOBELLIA_3689 ZOBELLIA_3689 4320105 4320974 - Serine endopeptidase%2C family S54 Serine endopeptidase belonging to the family S54. This family includes the protein Rhomboid which is a peptidase important for embryo development in Drosophila melanogaster. The active site is a catalytic diad Ser%2C His. Features seven transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene3689 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3689 ZOBELLIA_369 ZOBELLIA_369 susA susA 500010 501443 - Alpha-amylase%2C family GH13 SusA is a monomeric enzyme that endohydrolyses the 1%2C4-alpha-D-glucosidic linkages in starch%2C glycogen and related polysaccharides and oligosaccharides in a random manner. Reducing groups are liberated in the alpha-configuration%3B Belongs to the glycosyde hydrolase 13 family (GH13)%3B Binds one calcium ion per subunit%3B Signal peptide of lipoprotein cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene369 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_369 ZOBELLIA_3690 ZOBELLIA_3690 ZOBELLIA_3690 4320976 4321719 - Serine endopeptidase%2C family S54 Serine endopeptidase belonging to the family S54. This family includes the protein Rhomboid which is a peptidase important for embryo development in Drosophila melanogaster. The active site is a catalytic diad Ser%2C His. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene3690 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3690 ZOBELLIA_3691 ZOBELLIA_3691 mutL mutL 4321720 4323576 - DNA mismatch repair protein MutL MutL is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a \\molecular matchmaker\\%2C a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3691 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3691 ZOBELLIA_3692 ZOBELLIA_3692 ZOBELLIA_3692 4323576 4323875 - Conserved hypothetical membrane protein Contains a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3692 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3692 ZOBELLIA_3693 ZOBELLIA_3693 ribH ribH 4324108 4324590 - Riboflavin synthase beta chain Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2%2C4(1H%2C3H)-pyrimidinedione and L-3%2C4-dihydrohy-2-butanone-4-phosphate via 6%2C7-dimethyl-8-lumazine. It consists of 3 alpha subunits and 60 beta subunits. The beta subunits are arranged in twelve pentamers that give rise to a capsid. The capsid encloses the trimer of alpha subunits. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino- 2%2C4(1H%2C 3H)-pyrimidinedione with L-3%2C4-dihydrohy-2-butanone-4-phosphate yielding 6%2C7-dimethyl-8-lumazine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3693 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3693 ZOBELLIA_3694 ZOBELLIA_3694 ZOBELLIA_3694 4324590 4325357 - TPR repeats protein Conserved protein containing three C-terminal tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Contains a transmembrane helix in the N-terminal region%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3694 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3694 ZOBELLIA_3695 ZOBELLIA_3695 recF recF 4325472 4326557 + DNA replication and repair protein RecF The recF protein is involved in DNA metabolism%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3695 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3695 ZOBELLIA_3696 ZOBELLIA_3696 ZOBELLIA_3696 4326600 4327016 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3696 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3696 ZOBELLIA_3697 ZOBELLIA_3697 ZOBELLIA_3697 4327020 4327316 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3697 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3697 ZOBELLIA_3698 ZOBELLIA_3698 ndkA ndkA 4327381 4327800 - Nucleoside diphosphate kinase Nucleoside diphosphate kinase (NDK) is an important housekeeping enzyme involved in the production of the NTPs and dNTPs (other than ATP) vital for DNA and RNA synthesis and macromolecular metabolism%3B NDKs are proteins that act via a ping-pong mechanism in which a histidine residue is phosphorylated%2C by transfer of the gamma phosphate group from ATP. In the presence of magnesium%2C the phosphoenzyme can transfer its phosphate group to any beta phosphate group of the NDP%2C to produce an NTP%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3698 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3698 ZOBELLIA_3699 ZOBELLIA_3699 phoD3 phoD3 4327849 4328898 - Alkaline phosphatase Alkaline phosphatase is a zinc and magnesium-containing metalloenzyme which hydrolyzes phosphate esters%2C optimally at high pH%3B Alkaline phosphatase exists as a dimer%2C each monomer binding 2 zinc atoms and one magnesium atom%2C which are essential for enzymic activity%3B Signal peptide of lipoprotein cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene3699 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3699 ZOBELLIA_37 ZOBELLIA_37 ZOBELLIA_37 37508 38116 - Conserved protein containing a HTH motif Conserved hypothetical protein featuring a C-terminal helix-turn-helix DNA-binding motif. Localized in the cytoplasm.%3B~Conserved hypothetical protein gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_37 ZOBELLIA_370 ZOBELLIA_370 susE susE 501524 502672 - Starch utilization lipoprotein The Sus (starch utilization system) proteins probably are involved in the starch catabolism%3B Contains a putatif starch binding domain (CBM20)%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Function unclear gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_370 ZOBELLIA_3700 ZOBELLIA_3700 ZOBELLIA_3700 4328977 4329993 + Phosphoesterase Contains a N-terminal DHH domain predicted as phosphoesterase and a C-terminal DHHA1 domain%3B It is predicted that this family of proteins all perform a phosphoesterase function%3B Belongs to the DHH family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3700 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3700 ZOBELLIA_3701 ZOBELLIA_3701 gldI gldI 4329990 4330541 + Gliding motility FKBP-type peptidyl-prolyl cis-trans isomerase GldI%2C lipoprotein required for gliding motility%2C contains a Peptidyl-prolyl cis-trans isomerase (PPIase) domain%3B PPIases catalyze the peptidyl-prolyl isomerisation of the peptide bond preceding proline that is stabilised in the cis conformation in oligopeptides%3B GldI may be involved in folding cell envelope protein components of the motility machinery%3B Signal peptide cleaved between the residues 14 and 15%3B Localized in the outer membrane or/and cytoplasmic membrane%3B~High confidence in function and specificity gene gene3701 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3701 ZOBELLIA_3702 ZOBELLIA_3702 ppiA ppiA 4330592 4331704 + peptidyl-prolyl cis-trans isomerase Peptidyl-prolyl cis-trans isomerase%2C or PPIase or rotamase%2C accelerates the folding of proteins. It catalyzes the peptidyl-prolyl isomerisation during which the peptide bond preceding proline is stabilised in the cis conformation in oligopeptides%3B Contains a N-terminal Cyclophilin type PPIase/CLD domain and a C-terminal FKBP-type peptidyl-prolyl cis-trans isomerase domain%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3702 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3702 ZOBELLIA_3703 ZOBELLIA_3703 bglC bglC 4331877 4332953 + Endo-beta-1%2C4-glucanase%2C family GH5 BglC hydrolyzes the beta-1%2C4 linkages of carboxylmethylcellulose%3B Belongs to the family 5 of the glycoside hydrolases (GH5)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3703 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3703 ZOBELLIA_3704 ZOBELLIA_3704 ZOBELLIA_3704 4333220 4333576 + DUF805 family protein Conserved protein belonging to the DUF805 family. Features two transmembrane helices. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene3704 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3704 ZOBELLIA_3705 ZOBELLIA_3705 pepD2 pepD2 4333633 4335093 - Xaa-His dipeptidase%2C family M20 Xaa-His dipeptidase%2C also known as aminoacyl-histidine dipeptidase%2C catalyzes the hydrolysis of Xaa-|-His dipeptides. This dipeptidase has specificity for the unusual dipeptide beta-alanyl-L-histidine. Belongs to the family M20 of the metallopeptidase. PepD binds two co-catalytic zinc ions%2C which are coordinated by five conserved residues (His/Asp%2C Asp%2C Glu%2C Glu/Asp%2C His). The zinc ions stabilize the tetrahedral intermediate and activate the catalytic water molecule. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3705 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3705 ZOBELLIA_3706 ZOBELLIA_3706 ZOBELLIA_3706 4335249 4336316 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3706 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3706 ZOBELLIA_3707 ZOBELLIA_3707 moeA2 moeA2 4336366 4337556 - Molybdopterin biosynthesis protein Enzyme Involved in the biosynthesis of molybdopterin%2C necessary for molybdo-enzymes. MoeA%2C together with MoaB%2C is responsible for the metal incorporation into molybdopterin%2C the third step in molybdenum cofactor biosynthesis%3B Binds one magnesium ion%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3707 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3707 ZOBELLIA_3708 ZOBELLIA_3708 lepB lepB 4337590 4339290 - Signal peptidase I%2C family S26 The type-1 signal peptidase (SPase I%3B also known as leader peptidase I) is a serine protease that removes the signal peptides from the majority of exported pre-proteins. SPase I is an integral membrane protein that is anchored in the cytoplasmic membrane by four N-terminal transmembrane segments with the main part of the protein protuding in the periplasmic space%3B Contains an additional C-terminal transmembrane segments%3B Belongs to family 26 (clan SF) of serine peptidases (S26)%2C S26A subfamily%3B~High confidence in function and specificity gene gene3708 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3708 ZOBELLIA_3709 ZOBELLIA_3709 dapB dapB 4339396 4340097 - Dihydrodipicolinate reductase Dihydrodipicolinate reductase reduces the alpha%2C beta-unsaturated cyclic imine%2C dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso- diaminopimelate%2C which are critical for both protein and cell wall biosynthesis. DapB activity is repressed by lysine. It forms a homotetramer and binds one NAD(P) per subunit as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3709 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3709 ZOBELLIA_371 ZOBELLIA_371 susD susD 502685 504310 - Starch utilization lipoprotein The Sus (starch utilization system) proteins are involved in the starch catabolism%3B The SusD protein seems involved in starch binding and belongs to the SusD/RagB family%3B The Genes of this family are very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Family membership gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_371 ZOBELLIA_3710 ZOBELLIA_3710 ZOBELLIA_3710 4340148 4340789 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3710 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3710 ZOBELLIA_3711 ZOBELLIA_3711 parB parB 4340782 4341684 - Chromosome-partitioning protein parB ParB is involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3711 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3711 ZOBELLIA_3712 ZOBELLIA_3712 parA parA 4341684 4342457 - Chromosome partitioning protein ParA ParA is cnvolved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3712 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3712 ZOBELLIA_3713 ZOBELLIA_3713 divIC divIC 4342871 4343203 - Cell division protein DivIC DivIC is required for septum formation. Required for the activation of genes expressed under the control of the sporulation transcription factors sigma F and sigma E. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3713 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3713 ZOBELLIA_3714 ZOBELLIA_3714 udk udk 4343206 4343814 - Uridine kinase Uridine kinase (pyrimidine ribonucleoside kinase) is the rate-limiting enzyme in the pyrimidine salvage pathway. It catalyzes the reactions: ATP + uridine %3D ADP + UMP and ATP + cytidine %3D ADP + CMP. It forms a homotetramer and binds a ATP per subunit as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3714 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3714 ZOBELLIA_3715 ZOBELLIA_3715 ZOBELLIA_3715 4343924 4345132 + Drug resistance transporter The Drug resistance transporter%2C Bcr/CflA family belongs to the major facilitator superfamily (MFS) transporters. They are single-polypeptide secondary carriers capable only of transporting small solutes (probably antibiotics in this case) in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3715 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3715 ZOBELLIA_3716 ZOBELLIA_3716 acs acs 4345222 4347129 - Acetyl-coenzyme A synthetase Acetyl-coenzyme A synthetase%2C also known as Acetate-CoA ligase%2C enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle%2C and biosynthetic compounds via the glyoxylate shunt. It catalyzes the reaction: ATP + acetate + CoA %3D AMP + diphosphate + acetyl-CoA. Belongs to the ATP-dependent AMP-binding enzyme family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3716 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3716 ZOBELLIA_3717 ZOBELLIA_3717 ZOBELLIA_3717 4347226 4348938 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains thirteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3717 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3717 ZOBELLIA_3718 ZOBELLIA_3718 ZOBELLIA_3718 4348960 4349220 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3718 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3718 ZOBELLIA_3719 ZOBELLIA_3719 ZOBELLIA_3719 4349278 4350357 - UPF0075 family protein Conserved protein belonging to the UPF0075 family. Localized in the cytoplasm.%3B~Family membership gene gene3719 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3719 ZOBELLIA_372 ZOBELLIA_372 susC susC 504321 507227 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Possibly involved in the uptake of starch%3B Contains a carboxypeptidase regulatory domain (22-95) and the Plug module (111-227) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_372 ZOBELLIA_3720 ZOBELLIA_3720 ZOBELLIA_3720 4350354 4351934 - Beta-N-acetylglucosaminidase%2C family GH3 Beta-N-acetylglucosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. It belongs to the family 3 of the glycoside hydrolases.%3B~High confidence in function and specificity gene gene3720 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3720 ZOBELLIA_3721 ZOBELLIA_3721 ampG ampG 4351927 4353201 - Protein AmpG Protein AmpG is a signal transducer in beta-lactamase induction. It probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling. Belongs to the major facilitator superfamily. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3721 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3721 ZOBELLIA_3722 ZOBELLIA_3722 nagB2 nagB2 4353473 4355404 - Glucosamine-6-phosphate deaminase / PIG-L family deacetylase Bifunctional enzyme with a N-terminal glucosamine-6-phosphate (GlcN6P) deaminase domain and a C-terminal deacetylase domain. GlcN6P deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate to form fructose 6-phosphate and ammonium ion in the N-acetylglucosamine utilization pathway. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. The C-terminal domain belongs to the PIG-L family%2C which includes various deacetylases%2C such as the mammalian and yeast N-acetylglucosaminylphosphatidylinositol de-N-acetylase and the diacetylchitobiose deacetylase from Pyrococcus kodakaraensis. The specificity of this C-terminal deacetylase is unclear. Localized in the cytoplasm.%3B~Specificity unclear gene gene3722 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3722 ZOBELLIA_3723 ZOBELLIA_3723 ZOBELLIA_3723 4355596 4356345 + DeoR-type transcriptional regulator DeoR-type transcription regulator are repressors of sugar and nucleoside metabolic systems. The effector molecules are generally phosphorylated intermediates of the relevant metabolic pathway. Contains a N-terminal DNA-binding DeoR-type HTH domain. The C-terminal part can contain an effector-binding domain and/or an oligomerization domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene3723 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3723 ZOBELLIA_3724 ZOBELLIA_3724 murQ murQ 4356351 4357160 + N-acetylmuramic acid 6-phosphate etherase MurQ specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6-phosphate and D-lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with anmK%2C is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3724 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3724 ZOBELLIA_3725 ZOBELLIA_3725 ZOBELLIA_3725 4357162 4357575 - Cytochrome c Cytochromes c typically function in electron transfer. The heme group is covalently attached by thioether bonds to two conserved cysteine residues (Cys-x-x-Cys-His motif). The conserved histidine residue is one of the two axial ligands of the heme iron. Features a signal peptide cleaved between the residues 24 and 25. Localized in the periplasm.%3B~Specificity unclear gene gene3725 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3725 ZOBELLIA_3726 ZOBELLIA_3726 gdhB3 gdhB3 4357599 4358720 - Quinoprotein glucose dehydrogenase Lipoprotein putatively localized in the outer membrane is a soluble glucose dehydrogenase (s-GDH) that oxidizes glucose to gluconolactone using a quinone as cofactor%3B Signale peptide cleaved between the residues 18 and 19%3B~Family membership gene gene3726 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3726 ZOBELLIA_3727 ZOBELLIA_3727 ZOBELLIA_3727 4358859 4367642 + Conserved hypothetical protein Signal peptide cleaved between the residues 27 and 28%3B Putatively localized in the outer membrane (PSORT result) gene gene3727 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3727 ZOBELLIA_3728 ZOBELLIA_3728 ZOBELLIA_3728 4367769 4368488 + Carbohydrate esterase%2C family CE1 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted carbohydrates%3B Belongs to the family 1 of the carbohydrate esterases (CE1)%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Specificity unclear gene gene3728 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3728 ZOBELLIA_3729 ZOBELLIA_3729 ZOBELLIA_3729 4368673 4369785 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3729 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3729 ZOBELLIA_373 ZOBELLIA_373 ZOBELLIA_373 507906 510407 - Conserved hypothetical protein Conserved protein containing a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_373 ZOBELLIA_3730 ZOBELLIA_3730 ZOBELLIA_3730 4369859 4370959 - Conserved hypothetical membrane protein Conserved protein belonging to the DUF20 family proteins predicted to be permeases%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3730 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3730 ZOBELLIA_3731 ZOBELLIA_3731 ZOBELLIA_3731 4370988 4371638 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3731 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3731 ZOBELLIA_3732 ZOBELLIA_3732 rsmE rsmE 4371862 4372569 - m3U1498 16S rRNA methyltransferase RsmE%2C previously known as YggJ%2C is a SAM-dependent methyltransferase which specifically methylates U1498 in 16S ribosomal RNA. Belongs to the alpha/beta knot methyltransferase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3732 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3732 ZOBELLIA_3733 ZOBELLIA_3733 camP camP 4372645 4373682 - O-Sialoglycoprotein endopeptidase%2C family M22 The cohemolysin CamP is a O-sialoglycoprotein endopeptidase. In glycophorin A%2C this enzyme cleaves the Arg31-Asp32 bond. Does not cleave unglycosylated proteins%2C desialylated glycoproteins or glycoproteins that are only N-glycosylated. Belongs to the family 22 of the metallopeptidases. The catalytic motif encompasses two conserved histidines which bind a zinc ion. Secreted in the extracellular medium.%3B~High confidence in function and specificity gene gene3733 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3733 ZOBELLIA_3734 ZOBELLIA_3734 ZOBELLIA_3734 4373764 4378194 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3734 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3734 ZOBELLIA_3735 ZOBELLIA_3735 pfkA pfkA 4378467 4379453 + 6-Phosphofructokinase%2C isoenzyme 1 6-Phosphofructokinase catalyzes the thirth step of glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-fructose 6-phosphate to D-fructose 1%2C6-bisphosphate. It is an allosteric homotetramer enzyme. Because the reaction catalyzed by Phosphofructokinase is energetically very favorable%2C it is essentially irreversible%3B Belongs to the carbohydrate kinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3735 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3735 ZOBELLIA_3736 ZOBELLIA_3736 gapA gapA 4379476 4380477 + Glyceraldehyde 3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1%2C3-diphospho-glycerate. Also it plays an important role in gluconeogenesis%3B Acts as an homotetramer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3736 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3736 ZOBELLIA_3737 ZOBELLIA_3737 ZOBELLIA_3737 4380560 4381411 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3737 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3737 ZOBELLIA_3738 ZOBELLIA_3738 ZOBELLIA_3738 4381472 4381852 - Endoribonuclease Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Belongs to the ribonuclease L-PSP family. This family includes the rat liver perchloric acid-soluble protein (L-PSP)%2C which has been shown to be a ribonuclease%2C and the protein yabJ from Bacillus subtilis involved in the regulation of the purine biosynthetic gene purA. Localized in the cytoplasm.%3B~Family membership gene gene3738 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3738 ZOBELLIA_3739 ZOBELLIA_3739 ZOBELLIA_3739 4381920 4384661 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3739 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3739 ZOBELLIA_374 ZOBELLIA_374 ZOBELLIA_374 510505 513480 - Conserved hypothetical protein Conserved lipoprotein that seems to contain%2C in its central part%2C three BON (bacterial OsmY and nodulation) domains that are likely to be a phospholipid-binding domain that is involved in osmotic-shock protection and other cell-membrane-localized processes%3B Signal peptide cleaved between the residues 20 and 21%3B localized in the outer membrane gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_374 ZOBELLIA_3740 ZOBELLIA_3740 amiA amiA 4384766 4386145 + N-acetylmuramoyl-L-alanine amidase The protein contains two domains. A N-terminal N-acetylmuramoyl-L-alanine amidase domain (230 residues) that hydrolyzes the amide bond between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell walls and a C-terminal domain (200 residues) of unknown function%3B Contains one N-terminal transmembrane segment%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3740 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3740 ZOBELLIA_3741 ZOBELLIA_3741 ZOBELLIA_3741 4386246 4387226 + Possible ABC importer%2C periplasmic component Protein of unknown function that could be the periplasmic component of a ABC transporter (importer)%3B Contains a Mce (mammalian cell entry) domain and one N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3741 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3741 ZOBELLIA_3742 ZOBELLIA_3742 ZOBELLIA_3742 4387227 4388555 + Possible ABC importer%2C permease component Membrane protein that could be the permease component of an ABC transporter (importer)%3B Contains six N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3742 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3742 ZOBELLIA_3743 ZOBELLIA_3743 ZOBELLIA_3743 4388605 4389396 + Possible oxidoreductase Protein that could be an oxidoreductase%3B Contains two cysteine-rich regions (CCG domains)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3743 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3743 ZOBELLIA_3744 ZOBELLIA_3744 ZOBELLIA_3744 4389436 4389918 + Possible ABC importer%2C ATPase component Conserved hypothetical protein that could be an ATP-binding protein%3B Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene3744 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3744 ZOBELLIA_3745 ZOBELLIA_3745 ZOBELLIA_3745 4390026 4392935 + Beta-N-acetylglucosaminidase%2C family GH3 / Serine peptidase%2C family S12 This is a modular protein with a N-terminal beta-N-acetylglucosaminidase domain and a C-terminal serine peptidase domain. The beta-N-acetylglucosaminidase module belongs to the family 3 of the glycoside hydrolases. It catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. The C-terminal domain belongs to the family 12 of the serine peptidases D-Ala-D-Ala carboxypeptidase B and aminopeptidase DmpB. Features a signal peptide cleaved between residues 19 and 20.%3B~Specificity unclear gene gene3745 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3745 ZOBELLIA_3746 ZOBELLIA_3746 ZOBELLIA_3746 4393090 4394235 + Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 4 of the glycosyltransferases (GT4)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3746 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3746 ZOBELLIA_3747 ZOBELLIA_3747 ZOBELLIA_3747 4394237 4394680 + Conserved hypothetical protein Signal peptide of lipoprotein possibly cleaved between the residues 14 and 15%3B Localized in the cytoplasmic membrane gene gene3747 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3747 ZOBELLIA_3748 ZOBELLIA_3748 ZOBELLIA_3748 4394800 4395978 + OmpA-like periplasmic protein This conserved protein belongs to the OmpA-like family. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space and/or in the outer membrane%3B~Family membership gene gene3748 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3748 ZOBELLIA_3749 ZOBELLIA_3749 ZOBELLIA_3749 4395979 4398030 - Conserved hypothetical protein Contains an N-terminal haloacid dehalogenase (HAD) domain%3B Localized in the cytoplasm gene gene3749 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3749 ZOBELLIA_375 ZOBELLIA_375 traO traO 513501 513992 - Conjugative transposon protein TraO TraO is part of a conjugative transposon and is predicted to be involved in its transfer. Contains a signal peptide cleaved between the residues 24 and 25. Localized in the periplasmic space.%3B~Function unclear gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_375 ZOBELLIA_3750 ZOBELLIA_3750 ZOBELLIA_3750 4398331 4399512 - Conserved hypothetical protein Localized in the cytoplasm gene gene3750 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3750 ZOBELLIA_3751 ZOBELLIA_3751 ZOBELLIA_3751 4399548 4400519 - Hypothetical membrane protein Contains one N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3751 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3751 ZOBELLIA_3752 ZOBELLIA_3752 algI1 algI1 4400526 4401980 - Poly(beta-D-mannuronate) O-acetylase Poly(beta-D-mannuronate) O-acetylase%2C involved in glycan biosynthesis%2C forms an cytoplasmic membrane complex which probably interacts with a beta-D-mannuronate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid%3B Contains ten transmembrane segments%3B Belongs to the MBOAT (membrane-bound acyltransferase) family%3B~Specificity unclear gene gene3752 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3752 ZOBELLIA_3753 ZOBELLIA_3753 ZOBELLIA_3753 4402041 4403285 - Conserved hypothetical protein Localized in the cytoplasm gene gene3753 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3753 ZOBELLIA_3754 ZOBELLIA_3754 ZOBELLIA_3754 4403298 4404347 - Conserved hypothetical protein Localized in the cytoplasm gene gene3754 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3754 ZOBELLIA_3755 ZOBELLIA_3755 ZOBELLIA_3755 4404675 4405331 - Hydrolase HAD superfamily The hydrolases of the superfamily HAD (Haloacid dehalogenase) catalyse a nucleophilic displacement reaction%2C with water as the sole co-substrate. They are structurally different from the alpha/beta hydrolase family (abhydrolase)%3B Belongs to the haloacid dehalogenase- like hydrolase superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene3755 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3755 ZOBELLIA_3756 ZOBELLIA_3756 ZOBELLIA_3756 4405315 4406283 - ATP-grasp protein The ATP-grasp proteins catalyze the Magnesium- and ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule. They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate%3B Binds 3 manganese ions%3B Localized in the cytoplasm%3B~Function unclear gene gene3756 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3756 ZOBELLIA_3757 ZOBELLIA_3757 ZOBELLIA_3757 4406280 4407305 - Beta-(1%2C4)-galactosyltransferase%2C Family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. It is closely related to the beta-(1%2C4)-galactosyltransferase EspJ which is involved in the biosynthesis of exopolysaccharides in Lactobacillus delbrueckii.%3B~High confidence in function and specificity gene gene3757 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3757 ZOBELLIA_3758 ZOBELLIA_3758 ZOBELLIA_3758 4407296 4407874 - Exopolysaccharide production protein Conserved protein involved in exopolysaccharide biosynthesis. Its exact function is unknown. Contains a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~Function unclear gene gene3758 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3758 ZOBELLIA_3759 ZOBELLIA_3759 capM capM 4408188 4409333 - Capsular polysaccharide biosynthesis glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. This enzyme is likely involved in the biosynthesis of exopolysaccharides. Localized in the cytoplasm.%3B~Specificity unclear gene gene3759 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3759 ZOBELLIA_376 ZOBELLIA_376 ZOBELLIA_376 514040 515062 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 32 and 33%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_376 ZOBELLIA_3760 ZOBELLIA_3760 ZOBELLIA_3760 4409383 4410522 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene3760 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3760 ZOBELLIA_3761 ZOBELLIA_3761 asnB2 asnB2 4410545 4412395 - Asparagine synthase B Asparagine synthase (glutamine-hdrolysing) catalyses the conversion of aspartate to asparagine from glutamine as amido-N-donor. Contains a N-terminal class-2 glutamine amidotransferase domain (GATase domain). Forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3761 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3761 ZOBELLIA_3762 ZOBELLIA_3762 ZOBELLIA_3762 4412566 4413639 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene3762 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3762 ZOBELLIA_3763 ZOBELLIA_3763 asnB3 asnB3 4413731 4415587 - Asparagine synthase B Asparagine synthase (glutamine-hydrolyzing) catalyses the conversion of aspartate to asparagine from glutamine as amido-N-donor. Contains a N-terminal class-2 glutamine amidotransferase domain and a helix-turn-hlix motive. Forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3763 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3763 ZOBELLIA_3764 ZOBELLIA_3764 ZOBELLIA_3764 4415684 4417411 - Conserved hypothetical protein Protein that could contain an Asparagine synthase domain. However%2C the N-terminal class-II Glutamine amidotransferase domain is absent%3B Localized in the cytoplasm gene gene3764 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3764 ZOBELLIA_3765 ZOBELLIA_3765 ZOBELLIA_3765 4417524 4418705 - Conserved hypothetical membrane protein Proteins possibly involved in the synthesis of lipopolysaccharide (LPS)%3B Contains ten transmembrane segments and a C-terminal O-Antigen Polymerase domain%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3765 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3765 ZOBELLIA_3766 ZOBELLIA_3766 ZOBELLIA_3766 4418710 4419807 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm%3B~Specificity unclear gene gene3766 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3766 ZOBELLIA_3767 ZOBELLIA_3767 ZOBELLIA_3767 4419885 4420778 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene3767 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3767 ZOBELLIA_3768 ZOBELLIA_3768 ZOBELLIA_3768 4420949 4422487 - Conserved hypothetical membrane protein Membrane protein possibly involved in the export of O-antigen%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3768 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3768 ZOBELLIA_3769 ZOBELLIA_3769 ZOBELLIA_3769 4422487 4423494 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. Closely related to genes involved in the biosynthesis of capsular exopolysaccharides in Firmicutes. Features a C-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~Family membership gene gene3769 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3769 ZOBELLIA_377 ZOBELLIA_377 ZOBELLIA_377 515353 515616 + Hypothetical protein Probably localized in the cytoplasm gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_377 ZOBELLIA_3770 ZOBELLIA_3770 pelA1 pelA1 4423665 4425422 - Pectate lyase%2C family PL1 Pectate lyase catalyzes the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends%3B Contains a N-terminal domain of unknown function%3B Belongs to the family 1 of the polysaccharide lyases (PL1)%3B Lipoprotein signal peptide cleaved between the residues 23 and 24%2C Localized in the outer membrane%3B~High confidence in function and specificity gene gene3770 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3770 ZOBELLIA_3771 ZOBELLIA_3771 vipA vipA 4425849 4427129 - Vi polysaccharide biosynthesis protein vipA VipA is involved in the biosynthesis of an exopolysaccharide. In Salmonella typhi%2C this EPS is the Vi antigen. VipA belongs to the UDP-glucose/GDP-mannose dehydrogenase family%2C a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3771 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3771 ZOBELLIA_3772 ZOBELLIA_3772 wbpP wbpP 4427136 4428134 - UDP-N-acetylglucosamine 4-epimerase UDP-N-acetylglucosamine 4-epimerase converts the UDP-N-acetyl-D-glucosamine to UDP-N-acetyl-D-galactosamine. WbpP is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis%3B Belongs to the NAD dependent epimerase/dehydratase family%2C Rossmann fold Superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3772 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3772 ZOBELLIA_3773 ZOBELLIA_3773 ZOBELLIA_3773 4428380 4429489 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3773 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3773 ZOBELLIA_3774 ZOBELLIA_3774 pelA2 pelA2 4429750 4431837 - Pectate lyase%2C family PL1 Modular protein with a N-terminal TolA-like domain and a C-terminal pectate lyase domain. Pectate lyase catalyzes the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. The catalytic domain belongs to the family 1 of the polysaccharide lyases (PL1). Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3774 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3774 ZOBELLIA_3775 ZOBELLIA_3775 ZOBELLIA_3775 4432302 4433786 + Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3775 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3775 ZOBELLIA_3776 ZOBELLIA_3776 ZOBELLIA_3776 4433827 4434729 - Hypothetical membrane protein Contains one N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3776 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3776 ZOBELLIA_3777 ZOBELLIA_3777 algI2 algI2 4434733 4436175 - Poly(beta-D-mannuronate) O-acetylase Poly(beta-D-mannuronate) O-acetylase%2C involved in glycan biosynthesis%2C forms an cytoplasmic membrane complex which probably interacts with a beta-D-mannuronate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid%3B Contains 8 transmembrane segments%3B Belongs to the MBOAT (membrane-bound acyltransferase) family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3777 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3777 ZOBELLIA_3778 ZOBELLIA_3778 lpsL lpsL 4436292 4437308 - UDP-glucuronate 4-epimerase UDP-glucuronate 4-epimerase converts the UDP-glucuronate to UDP-D-galacturonate. LpsL is involved in lipopolysaccharide biosynthesis%3B Belongs to the NAD dependent epimerase/dehydratase family%2C Rossmann fold Superfamily%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3778 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3778 ZOBELLIA_3779 ZOBELLIA_3779 ugdH ugdH 4437305 4438714 - UDP-glucose 6-dehydrogenase UDP-glucose 6-dehydrogenase catalyzes the oxidation of UDP-glucose to UDP-glucuronate . Likely involves in EPS biosynthesis. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family%2C a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3779 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3779 ZOBELLIA_378 ZOBELLIA_378 ZOBELLIA_378 515595 516788 - Hypothetical protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_378 ZOBELLIA_3780 ZOBELLIA_3780 ZOBELLIA_3780 4439096 4440091 + UDP-glucuronic acid decarboxylase UDP-glucuronic acid decarboxylase converts the UDP-D-glucuronic acid to UDP-D-xylose and CO2. This enzyme is involved in the nucleotide sugar metabolism%3B Belongs to the NAD dependent epimerase/dehydratase family%2C Rossmann fold Superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3780 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3780 ZOBELLIA_3781 ZOBELLIA_3781 ZOBELLIA_3781 4440365 4440568 - Putative protein Hypothetical protein gene gene3781 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3781 ZOBELLIA_3782 ZOBELLIA_3782 ZOBELLIA_3782 4440656 4441624 + PLP-dependent aminotransferase This enzyme belongs to pyridoxal-phosphate (PLP)-dependent aminotransferase superfamily%2C DegT/DnrJ/EryC1/StrS aminotransferase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene3782 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3782 ZOBELLIA_3783 ZOBELLIA_3783 capD capD 4441629 4443560 + Polysaccharide biosynthesis protein CapD CapD is involved in EPS/LPS biosynthesis. Its exact function is unknown%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3783 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3783 ZOBELLIA_3784 ZOBELLIA_3784 ZOBELLIA_3784 4443601 4444401 + Polysaccharide export protein This membrane protein is likely involved in the export of expolysaccharide repeating units from the cytoplasm into the periplasm in a process analogous to O-unit export%3B Contains a C-terminal transmembrane helix%3B lipoprotein signal peptide cleaved between the residues 31 and 32%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3784 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3784 ZOBELLIA_3785 ZOBELLIA_3785 ptkA ptkA 4444435 4446816 + Tyrosine-protein kinase May be involved in the production and the transport of exopolysaccharides%3B Contains a N-terminal and a central transmembrane segment%3B Putatively autophosphorylated on several Tyr residues%3B Belongs to the etk/wzc family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3785 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3785 ZOBELLIA_3786 ZOBELLIA_3786 gdhB2 gdhB2 4447193 4453312 + Quinoprotein glucose dehydrogenase The mature protein is a multidomain protein: The first 430 residues would be The signal peptide is cleaved between the residues 26 and 27%3B Protein probably localized in the outer membrane%3B~Hypothetical protein gene gene3786 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3786 ZOBELLIA_3787 ZOBELLIA_3787 capC capC 4453402 4454142 - Tyrosine-protein phosphatase Dephosphorylates the phosphotyrosine-containing proteins required for the biosynthesis of type 1 capsular polysaccharide%3B Involved in the capsular polysaccharide (CPS) biosynthesis%3B Uses the mamganese as cofactor%3B Contains a polymerase and histidinol Phosphatase domain (PHP domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3787 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3787 ZOBELLIA_3788 ZOBELLIA_3788 ZOBELLIA_3788 4454339 4456570 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-97) and the Plug module (109-219) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene3788 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3788 ZOBELLIA_3789 ZOBELLIA_3789 ZOBELLIA_3789 4456675 4457151 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3789 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3789 ZOBELLIA_379 ZOBELLIA_379 ZOBELLIA_379 516882 517064 - Putative protein Hypothetical protein gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_379 ZOBELLIA_3790 ZOBELLIA_3790 ZOBELLIA_3790 4457236 4457376 - Putative protein Hypothetical protein gene gene3790 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3790 ZOBELLIA_3791 ZOBELLIA_3791 ZOBELLIA_3791 4457692 4459047 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3791 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3791 ZOBELLIA_3792 ZOBELLIA_3792 ZOBELLIA_3792 4459010 4459222 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3792 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3792 ZOBELLIA_3793 ZOBELLIA_3793 apbE3 apbE3 4459219 4460115 - Thiamine biosynthesis protein apbE ApbE is involved in the conversion of aminoimidazole ribotide (AIR)%2C a purine intermediate%2C to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3793 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3793 ZOBELLIA_3794 ZOBELLIA_3794 ZOBELLIA_3794 4460309 4461337 - NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family. Adopts a Rossmann fold. Localized in the cytoplasm.%3B~Specificity unclear gene gene3794 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3794 ZOBELLIA_3795 ZOBELLIA_3795 ZOBELLIA_3795 4461339 4462607 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3795 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3795 ZOBELLIA_3796 ZOBELLIA_3796 ZOBELLIA_3796 4462617 4464002 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3796 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3796 ZOBELLIA_3797 ZOBELLIA_3797 ZOBELLIA_3797 4464002 4464646 - Conserved hypothetical protein Conserved protein belonging to a family of putative cyclases. These proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site. Localized in the cytoplasm. gene gene3797 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3797 ZOBELLIA_3798 ZOBELLIA_3798 ttuC ttuC 4464661 4465725 - Tartrate dehydrogenase/decarboxylase Tartrate dehydrogenase/decarboxylase has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate%2C also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate. It uses NAD+ as a cofactor. Belongs to the Isocitrate dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3798 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3798 ZOBELLIA_3799 ZOBELLIA_3799 ZOBELLIA_3799 4465825 4466937 + LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene3799 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3799 ZOBELLIA_38 ZOBELLIA_38 ZOBELLIA_38 38200 38706 - Conserved hypothetical membrane protein Could belong to the Isoprenylcysteine carboxyl methyltransferase (ICMT) family%3B Contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_38 ZOBELLIA_380 ZOBELLIA_380 ZOBELLIA_380 517039 517449 - Hypothetical protein Putatively localized in the cytoplasm. gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_380 ZOBELLIA_3800 ZOBELLIA_3800 ZOBELLIA_3800 4466990 4469950 + Conserved hypothetical periplasmic protein Could be a possible enzyme acting with carbohydrates%3B Contains a signal peptide cleaved between the residues 30 and 31%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3800 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3800 ZOBELLIA_3801 ZOBELLIA_3801 ZOBELLIA_3801 4469958 4470803 + Conserved hypothetical membrane protein Protein that contains a domain of unknown function DUF1080%3B Putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3801 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3801 ZOBELLIA_3802 ZOBELLIA_3802 ZOBELLIA_3802 4470855 4472420 - Sulfatase%2C family S1-27 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 27%3B Lipoprotein with a signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Family membership gene gene3802 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3802 ZOBELLIA_3803 ZOBELLIA_3803 ZOBELLIA_3803 4472436 4474004 - Beta-helix fold protein This conserved protein likely adopts a right handed parallel beta-helix fold%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Function unclear gene gene3803 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3803 ZOBELLIA_3804 ZOBELLIA_3804 uglA2 uglA2 4473994 4475217 - Unsaturated glucuronyl hydrolase%2C family GH88 Unsaturated glucuronyl hydrolase is involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. UglA catalyzes the hydrolysis of oligosaccharides with unsaturated uronic acids at the nonreducing terminal%2C to a sugar or an amino sugar%2C and an unsaturated uronic acid%2C which is nonenzymatically converted immediately to alpha-keto acid%3B Belongs to the family 88 of the glycoside hydrolases (GH88)%3B Signal peptide cleaved between residues 22 and 23%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3804 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3804 ZOBELLIA_3805 ZOBELLIA_3805 ZOBELLIA_3805 4479440 4479640 + Putative protein Hypothetical protein gene gene3806 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3805 ZOBELLIA_3806 ZOBELLIA_3806 ZOBELLIA_3806 4475357 4479451 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3805 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3806 ZOBELLIA_3807 ZOBELLIA_3807 kduI4 kduI4 4479647 4480486 + 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase catalyzes the reaction is involved in pectin degradation in pectinolytic microorganism%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3807 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3807 ZOBELLIA_3808 ZOBELLIA_3808 idnO2 idnO2 4480489 4481283 + Gluconate-5-dehydrogenase Also called 5-keto-D-gluconate 5-reductase. Catalyzes the nonphosphorylative%2C ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate using NADP as a coenzyme. Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3808 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3808 ZOBELLIA_3809 ZOBELLIA_3809 ZOBELLIA_3809 4481288 4482484 + Conserved hypothetical protein Localized in the cytoplasm gene gene3809 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3809 ZOBELLIA_381 ZOBELLIA_381 ZOBELLIA_381 517659 518216 + Conserved hypothetical protein Localized in the cytoplasm. gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_381 ZOBELLIA_3810 ZOBELLIA_3810 maaA2 maaA2 4482539 4483111 - Maltose O-acetyltransferase Maltose O-acetyltransferase converts the maltose to acetyl-maltose from acetyl-CoA. Maltose O-acetyltransferase is a homodimer%2C responsible for exit of maltose and glucose in their acetylated forms%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3810 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3810 ZOBELLIA_3811 ZOBELLIA_3811 guaD guaD 4483180 4483662 - Guanine deaminase Guanine deaminase catalyzes the hydrolytic deamination of guanine%2C producing xanthine and ammonia . Expressed only during limited or partially limited nitrogen conditions. Can be induced to high levels in the presence of purines or intermediates of the purine catabolic pathway. GuaD adopts an alpha/beta/alpha three- layered fold and forms a homodimer. The essential zinc ion is ligated by a water molecule together with conserved residues%2C one histidine and two cysteine. Belongs to the cytidine and deoxycytidylate deaminase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3811 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3811 ZOBELLIA_3812 ZOBELLIA_3812 ZOBELLIA_3812 4484050 4486812 + Ligand-binding sensor protein Protein that consists of an N-terminal periplasmic beta-propeller followed by a C-terminal cytoplasmic domain containing a LuxR-type HTH domain acting as transcrptionnal regulator. A transmembrane segment is present between these two domains. Signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3812 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3812 ZOBELLIA_3813 ZOBELLIA_3813 ZOBELLIA_3813 4487077 4490115 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (25-99) and the Plug module (115-222) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene3813 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3813 ZOBELLIA_3814 ZOBELLIA_3814 ZOBELLIA_3814 4490128 4491666 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Probably localized in the outer membrane%3B~Family membership gene gene3814 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3814 ZOBELLIA_3815 ZOBELLIA_3815 ZOBELLIA_3815 4491692 4493488 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3815 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3815 ZOBELLIA_3816 ZOBELLIA_3816 ZOBELLIA_3816 4493530 4494888 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene3816 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3816 ZOBELLIA_3817 ZOBELLIA_3817 ZOBELLIA_3817 4494878 4496266 + Conserved membrane lipoprotein Contains a signal peptide cleaved between the residiues 17 and 18%3B Probably localized in the outer membrane%3B~Conserved hypothetical protein gene gene3817 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3817 ZOBELLIA_3818 ZOBELLIA_3818 bglX bglX 4496377 4498650 + Beta-glucosidase%2C family GH3 BglX catalyzes the hydrolysis of terminal%2C non-reducing beta-D-glucose residues with release of beta-D-glucose. Belongs to the family 3 of the glycoside hydrolases (GH3)%3B Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene3818 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3818 ZOBELLIA_3819 ZOBELLIA_3819 mdsA6 mdsA6 4498667 4500301 + Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Putative lipoprotein with a signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene3819 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3819 ZOBELLIA_382 ZOBELLIA_382 ZOBELLIA_382 518365 518487 + Conserved hypothetical protein Protein fragment found in proteins annotated as transposases%3B Localized in the cytoplasm gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_382 ZOBELLIA_3820 ZOBELLIA_3820 ZOBELLIA_3820 4500419 4503925 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3820 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3820 ZOBELLIA_3821 ZOBELLIA_3821 ZOBELLIA_3821 4503944 4505557 + FMN / Fe-S cluster binding protein Conserved protein containing a N-terminal Rieske [2Fe-2S] domain and a C-terminal domain Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene3821 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3821 ZOBELLIA_3822 ZOBELLIA_3822 ZOBELLIA_3822 4505568 4506302 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3822 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3822 ZOBELLIA_3823 ZOBELLIA_3823 ZOBELLIA_3823 4506305 4506958 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3823 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3823 ZOBELLIA_3824 ZOBELLIA_3824 ZOBELLIA_3824 4506965 4507588 + Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3824 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3824 ZOBELLIA_3825 ZOBELLIA_3825 ZOBELLIA_3825 4507585 4507944 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3825 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3825 ZOBELLIA_3826 ZOBELLIA_3826 ZOBELLIA_3826 4508174 4509619 + Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Putative lipoprotein with a signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Family membership gene gene3826 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3826 ZOBELLIA_3827 ZOBELLIA_3827 ZOBELLIA_3827 4509630 4510298 - Conserved hypothetical membrane protein Protein that consists of a SCO1/SenC domain%3B Contains a N-terminal transmembrane segment%3B Belongs to the SCO2/SenC family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3827 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3827 ZOBELLIA_3828 ZOBELLIA_3828 ZOBELLIA_3828 4510807 4512162 - Conserved hypothetical lipoprotein Lipoprotein with a signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3828 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3828 ZOBELLIA_3829 ZOBELLIA_3829 dnaN dnaN 4512416 4513534 - DNA polymerase III%2C beta chain The beta chain of DNA polymerase III is the processivity factor required for initiation of replication from an RNA primer%2C once it is clamped onto DNA. It slides freely (bidirectional and ATP-independent) along duplex DNA%3B The DNA polymerase III or replicase is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. The DNA polymerase III also exhibits a 3' to 5' exonuclease proofreading activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3829 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3829 ZOBELLIA_383 ZOBELLIA_383 srfAD srfAD 518587 519303 - Surfactin synthetase thioesterase Thioesterase involved in the biosynthesis of the antibiotic surfactin. Thioesterases are required for the addition of the last amino acid to the peptide antibiotic%2C thereby forming a cyclic antibiotic%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_383 ZOBELLIA_3830 ZOBELLIA_3830 gldG gldG 4513665 4515335 - Gliding motility membrane protein Membrane protein involved in the gliding motility%3B Ccontains a C-terminal transmembrane segment%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3830 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3830 ZOBELLIA_3831 ZOBELLIA_3831 gldF gldF 4515335 4516066 - Gliding motility permease%2C ABC-2 type exporter Belongs to Type 2 ABC (ATP-binding cassette) transporter%2C permease domain (ABC membrane)%3B Involved in the gliding motility%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3831 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3831 ZOBELLIA_3832 ZOBELLIA_3832 ZOBELLIA_3832 4516235 4517068 - Conserved hypothetical protein Contains the conserved domain DUF62%3B Probably localized in the cytoplasm gene gene3832 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3832 ZOBELLIA_3833 ZOBELLIA_3833 phoH phoH 4517359 4518312 + Protein PhoH PhoH is induced by phosphate starvation. It has an ATP-binding activity in vitro and is predicted to be a ATPase. Localized in the cytoplasm.%3B~Function unclear gene gene3833 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3833 ZOBELLIA_3834 ZOBELLIA_3834 purC purC 4518351 4519301 + Phosphoribosylaminoimidazole-succinocarboxamide synthase Phosphoribosylaminoimidazole-succinocarboxamide synthase catalyzes the seventh step in the de novo purine biosynthetic pathway: the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR. It forms a homotrimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3834 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3834 ZOBELLIA_3835 ZOBELLIA_3835 dnaQ dnaQ 4519306 4519962 - DNA polymerase III%2C epsilon subunit The epsilon subunit of DNA polymerase III is responsible of the proofreading 3'-5' exonuclease activity%3B The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It exhibits a DNA polymerase activity (alpha chain) and a 3' to 5' exonuclease proofreading activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3835 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3835 ZOBELLIA_3836 ZOBELLIA_3836 ZOBELLIA_3836 4519962 4521887 - Cyclic nucleotide-binding protein Conserved protein containing a N-terminal cyclic nucleotide-binding domain%2C a central CBS domain and a C-terminal DUF294 family domain. The cyclic nucleotide-binding domains are composed of three alpha-helices and a distinctive eight-stranded%2C antiparallel beta-barrel structure. CBS (cystathionine-beta-synthase) domains are small intracellular modules that pair together to form a stable globular domain. They bind ligands with an adenosyl group such as AMP%2C ATP and S-AdoMet and may play a regulatory role making proteins sensitive to adenosyl carrying ligands. DUF294 family proteins are found associated to CBS domains and are predicted as nucleotidyltransferases. Localized in the cytoplasm.%3B~Function unclear gene gene3836 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3836 ZOBELLIA_3837 ZOBELLIA_3837 ZOBELLIA_3837 4522057 4524297 + Conserved hypothetical membrane protein Conserved protein belonging to the DUF893 family%3B Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3838 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3837 ZOBELLIA_3838 ZOBELLIA_3838 ZOBELLIA_3838 4521960 4522058 - Putative protein Hypothetical protein gene gene3837 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3838 ZOBELLIA_3839 ZOBELLIA_3839 ZOBELLIA_3839 4524420 4524854 + Small heat shock protein Heat shock protein acts as chaperone that can protect other proteins against heat-induced denaturation and aggregation%3B Belongs to the HSP20 family. Hsp20 proteins seem to form large heterooligomeric aggregates%3B Localized in the cytoplasm%3B~Family membership gene gene3839 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3839 ZOBELLIA_384 ZOBELLIA_384 ZOBELLIA_384 519308 525586 - Type I polyketide synthase Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS)%2C acyltransferase (AC)%2C dehydratase (DH)%2C enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_384 ZOBELLIA_3840 ZOBELLIA_3840 ZOBELLIA_3840 4524939 4525031 - Putative protein Hypothetical protein gene gene3840 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3840 ZOBELLIA_3841 ZOBELLIA_3841 ZOBELLIA_3841 4525168 4525758 + Conserved hypothetical protein Localized in the cytoplasm gene gene3841 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3841 ZOBELLIA_3842 ZOBELLIA_3842 clsA2 clsA2 4525810 4527246 + Cardiolipin synthetase Cardiolipin synthetase is involved in phospholipids biosynthesis. It catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (diphosphatidylglycerol) and glycerol%3B Contains two N-terminal transmembrane helices%3B Belongs to the phospholipase D family%3B Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3842 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3842 ZOBELLIA_3843 ZOBELLIA_3843 ZOBELLIA_3843 4527318 4528094 + Patatin-like phospholipase Conserved protein belonging to the Patatin-like phospholipase family%3B Localized in the cytoplasm%3B~Family membership gene gene3843 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3843 ZOBELLIA_3844 ZOBELLIA_3844 ZOBELLIA_3844 4528335 4531613 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It autophosphorylates a conserved histidine in its phosphoacceptor domain and phosphorylates the receiver domain of response regulator%3B Contains three N-terminal PAS/PAC domains and a GAF domain is present in the central part of the protein. The Histidine kinase domain is localized in the C-terminal end%3B Seems localized in the cytoplasm%3B~Family membership gene gene3844 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3844 ZOBELLIA_3845 ZOBELLIA_3845 ZOBELLIA_3845 4531591 4532658 + Cyclic nucleotide-binding dependent two-component system-Response regulator The response regulators are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of a N-terminal receiver domain that is substrate for a histidine protein kinase sensor%2C a cyclic nucleotide-binding domain and a C-terminal Crp-type HTH domain (effector domain)%3B The Crp-type HTH domain binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons%3B~Specificity unclear gene gene3845 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3845 ZOBELLIA_3846 ZOBELLIA_3846 ZOBELLIA_3846 4532678 4532908 - Conserved hypothetical protein Localized in the cytoplasm gene gene3846 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3846 ZOBELLIA_3847 ZOBELLIA_3847 ZOBELLIA_3847 4532905 4533255 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3847 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3847 ZOBELLIA_3848 ZOBELLIA_3848 ZOBELLIA_3848 4533262 4533591 - Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3848 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3848 ZOBELLIA_3849 ZOBELLIA_3849 ZOBELLIA_3849 4533753 4534256 + Hypothetical protein Putatively localized in the cytoplasm gene gene3849 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3849 ZOBELLIA_385 ZOBELLIA_385 ZOBELLIA_385 525832 526503 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_385 ZOBELLIA_3850 ZOBELLIA_3850 ZOBELLIA_3850 4534348 4535118 + Conserved hypothetical protein Localized in the cytoplasm gene gene3850 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3850 ZOBELLIA_3851 ZOBELLIA_3851 ZOBELLIA_3851 4535205 4535612 + Conserved hypothetical protein Localized in the cytoplasm gene gene3851 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3851 ZOBELLIA_3852 ZOBELLIA_3852 ZOBELLIA_3852 4535827 4537026 - ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3852 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3852 ZOBELLIA_3853 ZOBELLIA_3853 ZOBELLIA_3853 4537023 4538210 - ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3853 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3853 ZOBELLIA_3854 ZOBELLIA_3854 ZOBELLIA_3854 4538215 4539189 - Membrane fusion protein These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region%3B Belongs to the type I secretion system%3B~Family membership gene gene3854 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3854 ZOBELLIA_3855 ZOBELLIA_3855 ZOBELLIA_3855 4539197 4540675 - Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Signal peptide cleaved between the residues 30 and 31%3B Localized in the outer membrane%3B~Family membership gene gene3855 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3855 ZOBELLIA_3856 ZOBELLIA_3856 ZOBELLIA_3856 4540776 4542047 - Multi-pass membrane transporter Membrane protein of unknown function probably acting as accessory protein to an ABC transporter%3B Contains an N-terminal MgtC domain and 12 transmembrane segments%3B Belongs to the MgtC/SapB family%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3856 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3856 ZOBELLIA_3857 ZOBELLIA_3857 ubiB ubiB 4542077 4543759 - Possible ubiquinone biosynthesis protein UbiB The function of this protein is not clear. The UbiB (or AarF) protein is involved%2C probably indirectly%2C in the first hydoxylation step in respiratory cofactor ubiquinone (coenzyme Q) biosynthesis. Although it is not known if it has protein kinase activity and what substrate it would phosphorylate (Ser%2C Thr or Tyr)%2C UbiB could play a role in ubiquinone biosynthesis-activating proteins necessary for the hydroxylase step(s) via phosphorylation%3B contains a protein kinase domain and two transmembrane segments%3B Belongs to the protein kinase superfamily%2C ADCK (ABC1/AarF domain containing kinase) family%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene3857 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3857 ZOBELLIA_3858 ZOBELLIA_3858 ZOBELLIA_3858 4543774 4544160 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene3858 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3858 ZOBELLIA_3859 ZOBELLIA_3859 rcaA rcaA 4544337 4546334 - Respiratory chain complexes assembly ATP-dependent metalloprotease ATP-dependent metalloprotease mediates degradation of non-assembled cytoplasmic membrane proteins. It is necessary for the assembly of respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides%3B Binds 1 zinc ion%3B Contains two N-terminal transmembrane segments%3B belongs%2C in the N-terminal part%2C to the AAA ATPase family and%2C in the C-terminal part%2C to the peptidase M41 family (clan MA(E))%3B Localized in the cytpolasmic membrane%3B~High confidence in function and specificity gene gene3859 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3859 ZOBELLIA_386 ZOBELLIA_386 ZOBELLIA_386 526988 527818 + Transposase (pseudogene)%2C Mutator family This protein corresponds to the N-terminal region of a transposase%3B The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the transposase mutator family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_386 ZOBELLIA_3860 ZOBELLIA_3860 ZOBELLIA_3860 4546336 4546683 - Carboxymuconolactone decarboxylase family protein Conserved protein belonging to the carboxymuconolactone decarboxylase family. Its exact function is not known. Localized in the cytoplasm.%3B~Family membership gene gene3860 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3860 ZOBELLIA_3861 ZOBELLIA_3861 ZOBELLIA_3861 4546986 4547639 + Conserved hypothetical protein Could contain a an uncleavable N-terminal signal sequence%3B Putatively localized in the cytoplasmic membrane gene gene3861 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3861 ZOBELLIA_3862 ZOBELLIA_3862 ZOBELLIA_3862 4547784 4548569 + Universal stress protein Stress protein probably induced when the cell is exposed to stress agents or when conditions cause growth arrest%3B Contains two copies of the universal stress protein (usp) domain%3B Belongs to the Usp family. Members of the Usp family are predicted to be related to the MADS- box proteins and bind to DNA%3B Localized in the cytoplasm%3B~Family membership gene gene3862 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3862 ZOBELLIA_3863 ZOBELLIA_3863 ZOBELLIA_3863 4548627 4549058 + Conserved hypothetical protein Localized in the cytoplasm gene gene3863 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3863 ZOBELLIA_3864 ZOBELLIA_3864 glkA glkA 4549120 4550193 - Glucokinase Glucokinase is involved in the first step of the glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-glucose to D-glucose 6-phosphate. This reaction consumes ATP%2C but it acts to keep the glucose concentration low%2C promoting continuous transport of glucose into the cell through the cytoplasmic membrane transporters%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3864 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3864 ZOBELLIA_3865 ZOBELLIA_3865 fbaB fbaB 4550211 4551257 - Fructose-bisphosphate aldolase%2C class 1 Fructose-bisphosphate aldolase catalyzes the fourth step of the glycolysis (Embden-Meyerhof pathway). It cleaves the hexose D-fructose 1%2C6-bisphosphate into two trioses sugars: the dihydroxyacetone phosphate (ketone) and the D-glyceraldehyde 3-phosphate (aldehyde)%3B Belongs to the DeoC/LacD aldolase family (Common phosphate binding- site TIM barrel superfamily)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3865 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3865 ZOBELLIA_3866 ZOBELLIA_3866 pfkB pfkB 4551279 4552220 - 6-Phosphofructokinase%2C isozyme 2 6-Phosphofructokinase catalyzes the thirth step of glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-fructose 6-phosphate to D-fructose 1%2C6-bisphosphate. It is an allosteric homodimer enzyme. Because the reaction catalyzed by Phosphofructokinase is energetically very favorable%2C it is essentially irreversible%3B Belongs to the carbohydrate kinase PfkB family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3866 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3866 ZOBELLIA_3867 ZOBELLIA_3867 gpmA gpmA 4552252 4552941 - 2%2C3-bisphosphoglycerate-dependent phosphoglycerate mutase The 2%2C3-bisphosphoglycerate-dependent phosphoglycerate mutase (PGAM) catalyzes the step 8 of the glycolysis (Embden-Meyerhof pathway). PGAM catalyzes the internal transfer of a phosphate group from C-3 to C-2 which results in the conversion of 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG) through a 2%2C3-bisphosphoglycerate intermediate%3B Belongs to the phosphoglycerate mutase family%2C BPG-dependent PGAM subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3867 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3867 ZOBELLIA_3868 ZOBELLIA_3868 ddh ddh 4552949 4553938 - 2-hydroxyacid dehydrogenase homolog NAD-dependent 2-hydroxyacid dehydrogenases are enzymes which seem to be specific for the D-isomer of their substrate. these enzymes are composed of a substrate-binding domain and a NAD-binding domain (Rossman fold)%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3868 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3868 ZOBELLIA_3869 ZOBELLIA_3869 ppsA ppsA 4553986 4556394 - Phosphoenolpyruvate synthase Phosphoenolpyruvate synthase is involved in gluconeogenesis when pyruvate and lactate are used as a carbon source. It generates phosphoenolpyruvate (PEP) from pyruvate%2C hydrolyzing ATP to AMP and releasing inorganic phosphate in the process%3B Uses the magnesium as cofactor%3B Belongs to the PEP-utilizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3869 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3869 ZOBELLIA_387 ZOBELLIA_387 ZOBELLIA_387 527799 528224 + Transposase (pseudogene)%2C Mutator family This protein corresponds to the C-terminal region of a transposase. The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the transposase mutator family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_387 ZOBELLIA_3870 ZOBELLIA_3870 ZOBELLIA_3870 4556397 4556501 - Putative protein Hypothetical protein gene gene3870 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3870 ZOBELLIA_3871 ZOBELLIA_3871 atpD2 atpD2 4556569 4558047 + ATP synthase%2C F1 sector beta subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). There are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex%2C while the remaining F1 subunits (gamma%2C delta%2C epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits%2C those on the beta subunits being catalytic%2C while those on the alpha subunits are regulatory. The alpha and beta subunits form a cylinder that is attached to the central stalk. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP%2C which are induced by the rotation of the gamma subunit%2C itself is driven by the movement of protons through the F0 complex C subunit.%3B~High confidence in function and specificity gene gene3871 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3871 ZOBELLIA_3872 ZOBELLIA_3872 atpC2 atpC2 4558064 4558453 + ATP synthase%2C F1 sector epsilon subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). The interaction site of subunit C of the F0 complex with the epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit).%3B~High confidence in function and specificity gene gene3872 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3872 ZOBELLIA_3873 ZOBELLIA_3873 atpI atpI 4558450 4558782 + ATP synthase gene 1 This protein is highly%3B~High confidence in function and specificity gene gene3873 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3873 ZOBELLIA_3874 ZOBELLIA_3874 ZOBELLIA_3874 4558868 4559077 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3874 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3874 ZOBELLIA_3875 ZOBELLIA_3875 atpB2 atpB2 4559079 4559807 + ATP synthase%2C F0 sector A subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). The A subunit is a key membrane component of the proton channel%2C and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring%2C which in turn is driven by the flux of protons through the membrane via the interface between the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain%2C and is thought to act as a stator to counter the tendency of subunit A and the F1 alpha-beta catalytic portion to rotate with the central rotary element.%3B~High confidence in function and specificity gene gene3875 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3875 ZOBELLIA_3876 ZOBELLIA_3876 atpE2 atpE2 4559870 4560139 + ATP synthase%2C F0 sector C subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). Ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring%2C which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor.%3B~High confidence in function and specificity gene gene3876 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3876 ZOBELLIA_3877 ZOBELLIA_3877 atpF2 atpF2 4560147 4560893 + ATP synthase%2C F0 sector B subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). The B subunits are part of the peripheral stalk that links the F1 and F0 complexes together%2C and which acts as a stator to prevent certain subunits from rotating with the central rotary element.%3B~High confidence in function and specificity gene gene3877 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3877 ZOBELLIA_3878 ZOBELLIA_3878 atpA2 atpA2 4560916 4562445 + ATP synthase%2C F1 sector alpha subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). There are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex%2C while the remaining F1 subunits (gamma%2C delta%2C epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits%2C those on the beta subunits being catalytic%2C while those on the alpha subunits are regulatory. The alpha and beta subunits form a cylinder that is attached to the central stalk. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP%2C which are induced by the rotation of the gamma subunit%2C itself is driven by the movement of protons through the F0 complex C subunit.%3B~High confidence in function and specificity gene gene3878 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3878 ZOBELLIA_3879 ZOBELLIA_3879 atpG2 atpG2 4562464 4563369 + ATP synthase%2C F1 sector gamma subunit ATP synthase produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases (also known as F1F0-ATPase%2C or H(+)-transporting two-sector ATPase) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha%2C beta%2C gamma%2C delta%2C epsilon)%2C while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C). In the F1 complex%2C the central gamma subunit forms the rotor inside the cylinder made of the alpha beta subunits%2C while in the F0 complex%2C the ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions%2C but the F0 rotor is usually stronger%2C using the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis.%3B~High confidence in function and specificity gene gene3879 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3879 ZOBELLIA_388 ZOBELLIA_388 ZOBELLIA_388 528244 528669 - Hypothetical lipoprotein Possible lipoprotein containing a signal peptide cleaved between the residues 16 and 17%3B Putatively localized in the outer membrane%3B~Hypothetical protein gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_388 ZOBELLIA_3880 ZOBELLIA_3880 ZOBELLIA_3880 4563476 4563928 - Conserved hypothetical protein Protein containing a Flavin mononucleotide binding domain%3B Belongs to the Pyridoxamine 5'-phosphate oxidase family%3B Localized in the cytoplasm%3B~Function unclear gene gene3880 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3880 ZOBELLIA_3881 ZOBELLIA_3881 ZOBELLIA_3881 4564208 4565188 - ABC importer%2C periplasmic component Periplasmic protein of unknown function anchored in the cytoplasmic membrane by a N-terminal transmembrane segment%3B could be involved in the uptake of organic solvents%3B Contains a Mce (mammalian cell entry) domain%3B Belongs to the periplasmic substrate-binding ABC transporter superfamily%3B~Specificity unclear gene gene3881 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3881 ZOBELLIA_3882 ZOBELLIA_3882 ZOBELLIA_3882 4565192 4565980 - ABC importer%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~Family membership gene gene3882 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3882 ZOBELLIA_3883 ZOBELLIA_3883 ZOBELLIA_3883 4565977 4566753 - ABC importer%2C permease component ABC (ATP-binding cassette) membrane protein responsible for translocation of a variety of compounds across biological membranes. Possibly involved in uptake of organic solvents such as gamma-Hexachlorocyclohexane or toluene for their utilization as source of carbon%3B Contains five transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3883 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3883 ZOBELLIA_3884 ZOBELLIA_3884 ZOBELLIA_3884 4566801 4566893 - Putative membrane protein Peptide that consists of a putative transmembrane helix possibly localized in the cytoplasmic membrane.%3B~Hypothetical protein gene gene3884 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3884 ZOBELLIA_3885 ZOBELLIA_3885 ZOBELLIA_3885 4566946 4568277 + Voltage-gated chloride channel Chloride channels constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. Features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene3885 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3885 ZOBELLIA_3886 ZOBELLIA_3886 cgaA cgaA 4568344 4570716 - Glucan 1%2C4-alpha-glucosidase%2C family GH15 Glucan 1%2C4-alpha-glucosidase%2C also known as glucoamylase%2C catalyzes the hydrolysis of terminal 1%2C4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. Belongs to the family 15 of the glycoside hydrolases. Involved in starch/glycogen metabolism.%3B~High confidence in function and specificity gene gene3886 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3886 ZOBELLIA_3887 ZOBELLIA_3887 ZOBELLIA_3887 4570995 4571486 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3887 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3887 ZOBELLIA_3888 ZOBELLIA_3888 ZOBELLIA_3888 4571806 4572720 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3888 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3888 ZOBELLIA_3889 ZOBELLIA_3889 ZOBELLIA_3889 4572830 4574956 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a Plug module (45-153) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene3889 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3889 ZOBELLIA_389 ZOBELLIA_389 ZOBELLIA_389 528695 529081 - Hypothetical membrane protein Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_389 ZOBELLIA_3890 ZOBELLIA_3890 ZOBELLIA_3890 4574968 4576392 + conserved hypothetical lipoprotein Signal peptide of prokaryotic lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3890 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3890 ZOBELLIA_3891 ZOBELLIA_3891 ZOBELLIA_3891 4576539 4576877 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3891 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3891 ZOBELLIA_3892 ZOBELLIA_3892 ZOBELLIA_3892 4576941 4578824 - Conserved hypothetical protein Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space gene gene3892 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3892 ZOBELLIA_3893 ZOBELLIA_3893 ZOBELLIA_3893 4579211 4582294 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules (here possibly sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (26-98) and the Plug module (114-224) acting as a channel gate%3B The signal peptide is cleaved between the residues 24 and 25%3B~Family membership gene gene3893 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3893 ZOBELLIA_3894 ZOBELLIA_3894 ZOBELLIA_3894 4582313 4583986 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Probably localized in the cytoplasmic membrane%3B~Family membership gene gene3894 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3894 ZOBELLIA_3895 ZOBELLIA_3895 ZOBELLIA_3895 4584185 4585735 + Sugars permease The Sugars permeases belong to the major facilitator superfamily (MFS) transporters that are single- polypeptide secondary carriers capable only of transporting small solutes (probably sugars in this case) in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3895 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3895 ZOBELLIA_3896 ZOBELLIA_3896 xynB xynB 4585732 4587327 + Beta-xylosidase%2C family GH43 Beta-xylosidase is an intracellular xylan-degrading enzyme. It catalyzes the hydrolysis of 1%2C4-beta-D-xylans%2C to remove successive D-xylose residues from the non-reducing termini. It belongs to the family GH43 of the glycoside hydrolases.%3B~High confidence in function and specificity gene gene3896 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3896 ZOBELLIA_3897 ZOBELLIA_3897 ZOBELLIA_3897 4587483 4588508 + LacI-type transcriptional regulator The LacI-type transcriptional regulators are involved in the repression and/or the positive regulation of genes encoding for catabolic enzymes and are important in the coordination of operons%3B They contain a N-terminal lacI-type HTH domain involved in the binding of the protein to the operator sequences in the DNA and a C- terminal periplasmic binding protein domain that are the primary receptors for chemotaxis and transport of many sugar based solutes that act as inducers%3B Localized in the cytoplasm%3B~Family membership gene gene3897 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3897 ZOBELLIA_3898 ZOBELLIA_3898 ZOBELLIA_3898 4588876 4591371 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene3898 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3898 ZOBELLIA_3899 ZOBELLIA_3899 ZOBELLIA_3899 4591425 4591562 + Putative protein Hypothetical protein gene gene3899 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3899 ZOBELLIA_39 ZOBELLIA_39 rdgB rdgB 38740 39309 + Nucleoside-triphosphate diphosphatase. Hydrolyzes%2C in presence of divalent cations%2C O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non-standard purines from DNA precursor pool%2C preventing thus incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the HAM1 NTPase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_39 ZOBELLIA_390 ZOBELLIA_390 ZOBELLIA_390 529339 529500 - Putative protein Hypothetical protein gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_390 ZOBELLIA_3900 ZOBELLIA_3900 ZOBELLIA_3900 4591584 4591979 - Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator. In this sequence%2C the effector domain is absent%3B~Family membership gene gene3900 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3900 ZOBELLIA_3901 ZOBELLIA_3901 ZOBELLIA_3901 4591991 4595971 - Two-component system hybrid-Sensor histidine kinase/Chemotaxis proteins The sensor histidine kinase belongs to two-component signal transduction systems. It autophosphorylates an histidine in its phosphoacceptor domain and phosphorylates an aspartic acid present in the response regulator receiver domain%3B Contains a CheB-type methylesterase catalytic domain and a CheR-type methyltransferase domain%2C both involved in the bacterial chemotaxis system%3B Contains a PAS/PAC domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene3901 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3901 ZOBELLIA_3902 ZOBELLIA_3902 ZOBELLIA_3902 4596170 4596805 - Two-component system-Response regulator Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA- binding activity (here%2C a LuxR-type HTH domain) that acts as transcriptional regulator%3B~Family membership gene gene3902 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3902 ZOBELLIA_3903 ZOBELLIA_3903 ZOBELLIA_3903 4596795 4598798 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Signal peptide cleaved between the residues 20 and 21%3B Contains four N- terminal tetratrico peptide repeats (TPR)%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3903 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3903 ZOBELLIA_3904 ZOBELLIA_3904 ZOBELLIA_3904 4598815 4599006 - Putative protein Hypothetical protein gene gene3904 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3904 ZOBELLIA_3905 ZOBELLIA_3905 ZOBELLIA_3905 4599052 4599474 + Hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene3905 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3905 ZOBELLIA_3906 ZOBELLIA_3906 ZOBELLIA_3906 4599481 4603404 + Extracellular metallopeptidase%2C family M4 This peptidase belongs to the family 4 of the metallopeptidases%2C which also contains thermolysin and related neutral peptidases. The conserved catalytic motif is HEXXE%2C in which the histidines are zinc ligands and the glutamate is a catalytic residue. The zinc ion is also bound by a second glutamate%2C 20-33 residues C-terminal to the HEXXH motif%2C and by an activated water molecule which forms the nucleophile in catalysis. Features a large C-terminal region of unknown function (621-1307)%2C which includes a TSP3 calcium-binding domain. Features a signal peptide cleaved between the residues 22 and 23. Most members of the family M4 are secreted enzymes that degrade extracellular proteins and peptides for bacterial nutrition.%3B~Specificity unclear gene gene3906 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3906 ZOBELLIA_3907 ZOBELLIA_3907 ZOBELLIA_3907 4603401 4604102 + Fibronectin type-III repeats protein Protein that contains two type-III fibronectin (FN3) domains. Structures of individual FN3 domains have revealed a conserved beta sandwich fold found in glycoside hydrolases and other proteins%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplamic membrane%3B~Family membership gene gene3907 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3907 ZOBELLIA_3908 ZOBELLIA_3908 ZOBELLIA_3908 4604103 4605395 + Conserved hypothetical lipoprotein This Protein likely adopts a beta-propeller fold%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3908 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3908 ZOBELLIA_3909 ZOBELLIA_3909 ZOBELLIA_3909 4605768 4607060 + Conserved hypothetical lipoprotein Protein that likely adopts a beta-propeller fold%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3909 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3909 ZOBELLIA_391 ZOBELLIA_391 ZOBELLIA_391 529610 530263 - Hypothetical protein Localized in the cytoplasm gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_391 ZOBELLIA_3910 ZOBELLIA_3910 ZOBELLIA_3910 4607267 4607848 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3910 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3910 ZOBELLIA_3911 ZOBELLIA_3911 ZOBELLIA_3911 4608173 4608601 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene3911 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3911 ZOBELLIA_3912 ZOBELLIA_3912 ZOBELLIA_3912 4608771 4609259 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Hypothetical protein gene gene3912 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3912 ZOBELLIA_3913 ZOBELLIA_3913 ZOBELLIA_3913 4609391 4609597 + Putative protein Hypothetical protein gene gene3913 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3913 ZOBELLIA_3914 ZOBELLIA_3914 ZOBELLIA_3914 4609719 4609817 + Putative protein Hypothetical protein gene gene3914 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3914 ZOBELLIA_3915 ZOBELLIA_3915 ZOBELLIA_3915 4609944 4610285 + Conserved hypothetical protein Localized in the cytoplasm gene gene3915 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3915 ZOBELLIA_3916 ZOBELLIA_3916 ZOBELLIA_3916 4610248 4610751 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule. Belongs to GNAT actyltransferase family. Localized in the cytoplasm.%3B~Family membership gene gene3916 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3916 ZOBELLIA_3917 ZOBELLIA_3917 ZOBELLIA_3917 4610816 4611367 + Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene3917 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3917 ZOBELLIA_3918 ZOBELLIA_3918 ZOBELLIA_3918 4611421 4611630 - Putative protein Hypothetical protein gene gene3918 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3918 ZOBELLIA_3919 ZOBELLIA_3919 ZOBELLIA_3919 4611702 4613675 + Conserved hypothetical protein The N-terminal region of this protein (~~200 residues) is conserved. The C-terminal region (~~400 residues) displays no similarity with known proteins%3B Localized in the cytoplasm gene gene3919 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3919 ZOBELLIA_392 ZOBELLIA_392 ZOBELLIA_392 530438 530614 - Putative protein Hypothetical protein gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_392 ZOBELLIA_3920 ZOBELLIA_3920 ZOBELLIA_3920 4613680 4614300 + Hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene3920 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3920 ZOBELLIA_3921 ZOBELLIA_3921 ZOBELLIA_3921 4614786 4615028 + Addiction module antidote protein Protein almost always found adjacent to a plasmid stabilization protein%2C which is the killing partner of an addiction module for plasmid stabilization. This Protein%2C therefore%2C would be the putative addiction module antidote protein%3B Contains a conserved GRY motif%3B Belongs to the uncharacterised protein family UPF0156%3B Localized in the cytoplasm%3B~Function unclear gene gene3921 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3921 ZOBELLIA_3922 ZOBELLIA_3922 ZOBELLIA_3922 4615025 4615327 + Plasmid stabilisation system protein Protein involved in plasmid stabilization. The exact molecular function of this protein is not known%3B Localized in the cytoplasm%3B~Function unclear gene gene3922 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3922 ZOBELLIA_3923 ZOBELLIA_3923 ZOBELLIA_3923 4615625 4615825 - Putative protein Hypothetical protein gene gene3923 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3923 ZOBELLIA_3924 ZOBELLIA_3924 ZOBELLIA_3924 4615943 4616548 + Conserved hypothetical lipoprotein Protein that contains three KWG repeats of unknown function%3B%2C Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3924 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3924 ZOBELLIA_3925 ZOBELLIA_3925 ZOBELLIA_3925 4616651 4617121 + Stress-induced protein This protein belongs to a family of stress-induced proteins encompassing OsmC from Escherichia coli and OhrB from Bacillus subtilis. Localized in the cytoplasm.%3B~Family membership gene gene3925 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3925 ZOBELLIA_3926 ZOBELLIA_3926 ZOBELLIA_3926 4617327 4617425 + Putative protein Hypothetical protein gene gene3926 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3926 ZOBELLIA_3927 ZOBELLIA_3927 ZOBELLIA_3927 4617453 4617566 + Putative protein Hypothetical protein gene gene3927 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3927 ZOBELLIA_3928 ZOBELLIA_3928 ZOBELLIA_3928 4617616 4618122 + Conserved hypothetical membrane protein Contains one C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene3928 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3928 ZOBELLIA_3929 ZOBELLIA_3929 ZOBELLIA_3929 4618186 4619019 + Conserved hypothetical protein Localized in the cytoplasm gene gene3929 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3929 ZOBELLIA_393 ZOBELLIA_393 ZOBELLIA_393 530710 531081 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_393 ZOBELLIA_3930 ZOBELLIA_3930 ZOBELLIA_3930 4619219 4619548 + Conserved hypothetical protein Localized in the cytoplasm gene gene3930 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3930 ZOBELLIA_3931 ZOBELLIA_3931 ZOBELLIA_3931 4619567 4619920 + Conserved hypothetical protein Localized in the cytoplasm gene gene3931 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3931 ZOBELLIA_3932 ZOBELLIA_3932 ZOBELLIA_3932 4620396 4620959 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3932 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3932 ZOBELLIA_3933 ZOBELLIA_3933 ZOBELLIA_3933 4621065 4622234 + Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3933 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3933 ZOBELLIA_3934 ZOBELLIA_3934 ZOBELLIA_3934 4622460 4625882 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (48-96)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (121-195) and a Plug module (211-316) acting as the channel gate%3B The signal peptide is cleaved between the residue 19 and 20%3B~Family membership gene gene3934 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3934 ZOBELLIA_3935 ZOBELLIA_3935 ZOBELLIA_3935 4625901 4627580 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Family membership gene gene3935 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3935 ZOBELLIA_3936 ZOBELLIA_3936 afcA7 afcA7 4627710 4630148 + Alpha-L-fucosidase%2C family GH95 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 95 of the glycoside hydrolases (GH95)%3B Features a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3936 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3936 ZOBELLIA_3937 ZOBELLIA_3937 ZOBELLIA_3937 4630202 4632091 + Conserved hypothetical periplasmic protein Conserved protein belonging to the DUF1680 family protein. Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Family membership gene gene3937 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3937 ZOBELLIA_3938 ZOBELLIA_3938 ZOBELLIA_3938 4632112 4634730 + Conserved hyypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3938 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3938 ZOBELLIA_3939 ZOBELLIA_3939 ZOBELLIA_3939 4634892 4636430 - Serine endopeptidase%2C family S54 Serine endopeptidase belonging to the family S54. This family includes the protein Rhomboid which is a peptidase important for embryo development in Drosophila melanogaster. The active site is a catalytic diad Ser%2C His. Features ten transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene3939 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3939 ZOBELLIA_394 ZOBELLIA_394 ZOBELLIA_394 531078 532109 - Hypothetical protein Localized in the cytoplasm gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_394 ZOBELLIA_3940 ZOBELLIA_3940 ZOBELLIA_3940 4636721 4637563 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene3940 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3940 ZOBELLIA_3941 ZOBELLIA_3941 hxlB hxlB 4637771 4638355 + 3-Hexulose-6-phosphate isomerase 3-Hexulose-6-phosphate isomerase catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate. Together with HxlA%2C may act as a formaldehyde detoxification system. It forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3941 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3941 ZOBELLIA_3942 ZOBELLIA_3942 hxlA hxlA 4638408 4639037 + 3-Hexulose-6-phosphate synthase 3-Hexulose-6-phosphate synthase catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with HxlB%2C may act as a formaldehyde detoxification system. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3942 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3942 ZOBELLIA_3943 ZOBELLIA_3943 ZOBELLIA_3943 4639082 4639360 + Putative protein Hypothetical protein gene gene3943 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3943 ZOBELLIA_3944 ZOBELLIA_3944 ZOBELLIA_3944 4639393 4640349 + anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3944 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3944 ZOBELLIA_3945 ZOBELLIA_3945 ZOBELLIA_3945 4640442 4643948 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules (here%2C Possibly sugars) that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (120-190)%2C and a Plug module (210-315) acting as the channel gate%3B The signal peptide is cleaved between the residue 28 and 29%3B~Family membership gene gene3945 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3945 ZOBELLIA_3946 ZOBELLIA_3946 ZOBELLIA_3946 4643961 4645694 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 16 and 17%3B Probably localized in the outer membrane%3B~Family membership gene gene3946 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3946 ZOBELLIA_3947 ZOBELLIA_3947 ZOBELLIA_3947 4645705 4646571 + Endonuclease/exonuclease/phosphatase family The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling%3B Belongs to the Endonuclease/Exonuclease/ phosphatase family%3B Signal peptide cleaved between the residues 22 and 23%3B Could be in the periplasmic space%3B~Family membership gene gene3947 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3947 ZOBELLIA_3948 ZOBELLIA_3948 ZOBELLIA_3948 4646718 4647242 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3948 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3948 ZOBELLIA_3949 ZOBELLIA_3949 ZOBELLIA_3949 4647373 4648158 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3949 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3949 ZOBELLIA_395 ZOBELLIA_395 ZOBELLIA_395 532117 532506 - Conserved hypothetical protein Localized in the cytoplasm. gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_395 ZOBELLIA_3950 ZOBELLIA_3950 ZOBELLIA_3950 4648192 4649496 - Xylose isomerase-like TIM barrel protein Conserved protein containing a N-terminal domain of unknown function and a C-terminal Xylose isomerase-like TIM barrel protein%3B Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Family membership gene gene3950 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3950 ZOBELLIA_3951 ZOBELLIA_3951 xynA xynA 4649779 4651209 + Endo-beta-1%2C4-xylanase%2C family GH10 Enzyme that Endohydrolyzes the beta-1%2C4-D-xylosidic linkages in xylans%3B Belongs to the family 10 of the glycoside hydrolases (GH10)%3B This protein is a lipoprotein with a signal peptide cleaved between the residues 18 and 19 and probably localized in the outer membrane%3B Contains a PKD-like domain in its N-treminal region%2C probably involved in protein-carbohydrate interactions%3B~High confidence in function and specificity gene gene3951 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3951 ZOBELLIA_3952 ZOBELLIA_3952 xynB xynB 4651240 4652436 + Endo-beta-1%2C4-xylanase%2C family GH10 Enzyme that Endohydrolyzes the beta-1%2C4-D-xylosidic linkages in xylans%3B Belongs to the family 10 of the glycoside hydrolases (GH10)%3B This protein is a lipoprotein with a signal peptide cleaved between the residues 24 and 25%2C and probably localized in the outer membrane%3B~High confidence in function and specificity gene gene3952 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3952 ZOBELLIA_3953 ZOBELLIA_3953 ZOBELLIA_3953 4652476 4652877 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3953 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3953 ZOBELLIA_3954 ZOBELLIA_3954 ZOBELLIA_3954 4653022 4653918 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3954 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3954 ZOBELLIA_3955 ZOBELLIA_3955 trpB2 trpB2 4654216 4655415 - Tryptophan synthase beta subunit The tryptophan synthase catalyzes the fifth and the last step in the biosynthesis of tryptophan. It is a tetramer of two alpha and two beta chains. The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine%3B Uses the pyridoxal phosphate (vitamin B6) as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3955 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3955 ZOBELLIA_3956 ZOBELLIA_3956 ZOBELLIA_3956 4656161 4657594 + DNA/RNA non-specific endonuclease Protein containing a N-terminal domain of unknown function and a C-terminal endonuclease domain. This endonuclease acts on both DNA and RNA%2C cleaves double-stranded and single-stranded nucleic acids and requires a divalent ion such as magnesium for its activity. A catalytic site is located in a conserved region which also contains an aspartate that could be implicated in the binding of the divalent ion%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B LOcalized in the outer membrane%3B~Function unclear gene gene3956 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3956 ZOBELLIA_3958 ZOBELLIA_3958 ZOBELLIA_3958 4658292 4658675 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3958 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3958 ZOBELLIA_3959 ZOBELLIA_3959 datA datA 4658733 4659578 + D-Amino-acid transaminase D-Amino-acid transaminase acts on the D-isomers of alanine%2C leucine%2C aspartate%2C glutamate%2C aminobutyrate%2C norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate prosthetic group to form pyridoxamine and an alpha-keto acid in the first half-reaction. the second half-reaction transferes the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate%2C which are essential bacterial cell wall components%3B Forms a homodimer and binds one pyridoxal phosphate as cofactor per subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3959 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3959 ZOBELLIA_396 ZOBELLIA_396 ZOBELLIA_396 532550 533899 - Conserved hypothetical protein Localized in the cytoplasm. gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_396 ZOBELLIA_3960 ZOBELLIA_3960 ZOBELLIA_3960 4659585 4660145 - Conserved hypothetical protein Conserved protein belonging to the DUF179 family. Localized in the cytoplasm.%3B~Family membership gene gene3960 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3960 ZOBELLIA_3961 ZOBELLIA_3961 hupB hupB 4660263 4660535 - DNA-binding protein HU%2C beta chain Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions. It forms a heterodimer of an alpha and a beta chain%3B Belongs to the bacterial histone-like protein family%3B localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3961 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3961 ZOBELLIA_3962 ZOBELLIA_3962 fmt fmt 4660710 4661657 - Methionyl-tRNA formyltransferase Methionyl-tRNA formyltransferase modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP. Its N-terminal domain carries the tetrahydrofolate (THF)-binding site and its C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3962 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3962 ZOBELLIA_3963 ZOBELLIA_3963 ZOBELLIA_3963 4661707 4663605 - ATP-dependent DNA helicase The ATP-dependent DNA helicases are involved in unwinding of DNA%3B Contains a DEAD/H dopmain involved in the ATP binding and a Helicase conserved C-terminal domain%3B Belongs to superfamily II of helicases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3963 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3963 ZOBELLIA_3964 ZOBELLIA_3964 ZOBELLIA_3964 4663605 4664168 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3964 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3964 ZOBELLIA_3965 ZOBELLIA_3965 ZOBELLIA_3965 4664256 4664543 + YbeD-like Protein YbeD adopts a alpha/beta fold with two alpha-helices on one side of a four-strand antiparallel beta-sheet. The beta-sheet surface contains a patch of conserved hydrophobic residues%2C suggesting a role in protein-protein interactions. YbeD shows striking structural homology to the regulatory domain from D-3- phosphoglycerate dehydrogenase%2C hinting at a role in the allosteric regulation of lipoic acid biosynthesis or the glycine cleavage system. Localized in the cytoplasm.%3B~Conserved hypothetical protein gene gene3965 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3965 ZOBELLIA_3966 ZOBELLIA_3966 ZOBELLIA_3966 4664623 4665279 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3966 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3966 ZOBELLIA_3967 ZOBELLIA_3967 murA murA 4665296 4666603 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase UDP-N-acetylglucosamine 1-carboxyvinyltransferase is involved in peptidoglycan biosynthesis. It adds enolpyruvyl to UDP-N-acetylglucosamine. Target for the antibiotic phosphomycin. It is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3967 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3967 ZOBELLIA_3968 ZOBELLIA_3968 ZOBELLIA_3968 4666619 4666939 + Conserved hypothetical protein Localized in the cytoplasm. gene gene3968 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3968 ZOBELLIA_3969 ZOBELLIA_3969 ZOBELLIA_3969 4666998 4667447 - Glyoxalase superfamily protein Contains a signal peptide cleaved between the residues 20 and 21%3B Belongs to the Glyoxalase superfamily%3B Localized in the periplasmic space%3B~Family membership gene gene3969 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3969 ZOBELLIA_397 ZOBELLIA_397 ZOBELLIA_397 533918 534370 - Conserved hypothetical protein Localized in the cytoplasm. gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_397 ZOBELLIA_3970 ZOBELLIA_3970 ZOBELLIA_3970 4667747 4668796 + conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene3970 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3970 ZOBELLIA_3971 ZOBELLIA_3971 phrA phrA 4668817 4670127 - Deoxyribodipyrimidine photo-lyase Deoxyribodipyrimidine photo-lyase is involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration)%2C which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. It binds a reduced FAD moiety as prosthetic group%2C and%2C in addition%2C either a reduced pterin or 8-hydroxy-5-diazaflavin as a second chromophore%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene3971 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3971 ZOBELLIA_3972 ZOBELLIA_3972 ZOBELLIA_3972 4670132 4670824 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene3972 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3972 ZOBELLIA_3973 ZOBELLIA_3973 ZOBELLIA_3973 4670838 4671476 - Conserved hypothetical protein Localized in the cytoplasm gene gene3973 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3973 ZOBELLIA_3974 ZOBELLIA_3974 ZOBELLIA_3974 4671495 4672766 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3974 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3974 ZOBELLIA_3975 ZOBELLIA_3975 ZOBELLIA_3975 4672847 4673692 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3975 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3975 ZOBELLIA_3976 ZOBELLIA_3976 ZOBELLIA_3976 4673796 4675538 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains thirteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene3976 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3976 ZOBELLIA_3977 ZOBELLIA_3977 ZOBELLIA_3977 4675539 4675640 - Putative protein Hypothetical protein gene gene3977 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3977 ZOBELLIA_3978 ZOBELLIA_3978 ZOBELLIA_3978 4675646 4678171 - Carbohydrate esterase%2C family CE14 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 14 of the carbohydrate esterases (CE14)%3B Signal peptide cleaved between residues 20and 21%3B Localized in the periplasmic space%3B~Specificity unclear gene gene3978 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3978 ZOBELLIA_3979 ZOBELLIA_3979 ZOBELLIA_3979 4678320 4678865 - Small-conductance mechanosensitive channel Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains three transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3979 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3979 ZOBELLIA_398 ZOBELLIA_398 ZOBELLIA_398 534492 534878 - Conserved hypothetical protein Localized in the cytoplasm. gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_398 ZOBELLIA_3980 ZOBELLIA_3980 ZOBELLIA_3980 4678874 4679821 - Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 23 and 24%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene3980 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3980 ZOBELLIA_3981 ZOBELLIA_3981 ZOBELLIA_3981 4679858 4680439 - Maf-like protein Maf is a putative inhibitor of septum formation in eukaryotes%2C bacteria%2C and archaea%3B belongs to the Maf family%3B Localized in the cytoplasm.%3B~Family membership gene gene3981 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3981 ZOBELLIA_3982 ZOBELLIA_3982 kdsC kdsC 4680442 4680969 - 3-Deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC is involved in lipolysaccharides (LPS) biosynthesis. It catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate%3B Binds one magnesium as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene3982 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3982 ZOBELLIA_3983 ZOBELLIA_3983 ZOBELLIA_3983 4680953 4681717 - Conserved hypothetical protein Localized in the cytoplasm. gene gene3983 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3983 ZOBELLIA_3984 ZOBELLIA_3984 nrfI nrfI 4682015 4685218 + Protein NrfI NrfI may play a role in cytochrome c biogenesis and may be required for maturation of the NrfA protein%2C involved in nitrite reduction%3B Contains 12 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene3984 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3984 ZOBELLIA_3985 ZOBELLIA_3985 ZOBELLIA_3985 4685230 4685814 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3985 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3985 ZOBELLIA_3986 ZOBELLIA_3986 ZOBELLIA_3986 4685934 4687085 + Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3986 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3986 ZOBELLIA_3987 ZOBELLIA_3987 ZOBELLIA_3987 4687248 4690628 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (50-101)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (134-198) and a Plug module (214-320) acting as the channel gate%3B The signal peptide is cleaved between the residue 19 and 20%3B~Family membership gene gene3987 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3987 ZOBELLIA_3988 ZOBELLIA_3988 ZOBELLIA_3988 4690633 4692414 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Probably localized in the cytoplasmic membrane%3B~Family membership gene gene3988 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3988 ZOBELLIA_3989 ZOBELLIA_3989 ZOBELLIA_3989 4692734 4693297 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene3989 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3989 ZOBELLIA_399 ZOBELLIA_399 ZOBELLIA_399 535250 536284 - PKD repeats protein Conserved protein containing two PKD domains. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~Family membership gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_399 ZOBELLIA_3990 ZOBELLIA_3990 ZOBELLIA_3990 4693489 4694616 + anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene3990 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3990 ZOBELLIA_3991 ZOBELLIA_3991 ZOBELLIA_3991 4694751 4698161 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (58-108)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (128-202)%2C and a Plug module (218-325) acting as the channel gate%3B The signal peptide is cleaved between the residue 27 and 28%3B~Family membership gene gene3992 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3991 ZOBELLIA_3992 ZOBELLIA_3992 ZOBELLIA_3992 4694636 4694746 - Putative protein Hypothetical protein gene gene3991 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3992 ZOBELLIA_3993 ZOBELLIA_3993 ZOBELLIA_3993 4698165 4699835 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 30 and 31%3B Putatively localized in the cytoplasmic membrane%3B~Family membership gene gene3993 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3993 ZOBELLIA_3994 ZOBELLIA_3994 ZOBELLIA_3994 4699838 4702366 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene3994 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3994 ZOBELLIA_3995 ZOBELLIA_3995 ZOBELLIA_3995 4702419 4703981 + Sulfatase%2C family S1-15 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 15%3B Putative lipoprotein with a signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~Family membership gene gene3995 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3995 ZOBELLIA_3996 ZOBELLIA_3996 ZOBELLIA_3996 4704350 4705030 + Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Contains a C-terminal transmembrane segment%3B Belongs to family 11 of transposases%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3996 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3996 ZOBELLIA_3997 ZOBELLIA_3997 ZOBELLIA_3997 4705119 4706738 - FAD-binding protein Conserved protein containing a putative FAD-binding domain in the N-terminal region. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene3997 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3997 ZOBELLIA_3998 ZOBELLIA_3998 ZOBELLIA_3998 4706716 4707318 - Endoribonuclease Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Belongs to the ribonuclease L-PSP family. This family includes the rat liver perchloric acid-soluble protein (L-PSP)%2C which has been shown to be a ribonuclease%2C and the protein yabJ from Bacillus subtilis involved in the regulation of the purine biosynthetic gene purA. Localized in the cytoplasm.%3B~Family membership gene gene3998 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3998 ZOBELLIA_3999 ZOBELLIA_3999 ZOBELLIA_3999 4707918 4708667 + Transposase%2C family 11 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to family 11 of transposases%3B Contains two transmembrane helices%2C the first in N-terminus%2C the second in C-terminus%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene3999 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_3999 ZOBELLIA_4 ZOBELLIA_4 ZOBELLIA_4 3642 4271 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplamic space%3B~Conserved hypothetical protein gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4 ZOBELLIA_40 ZOBELLIA_40 csdA csdA 39451 41241 + RNA helicase CsdA The ATP-dependent RNA helicase CsdA%2C originally named DeaD because of its homology with other DEAD box proteins%2C has a helix-destabilizing activity. It is known to be a cold shock protein%3B After induction by cold shock%2C CsdA is ribosome associated%3B Plays a key role in optimal cell growth at low temperature%3B Suppressor of a mutant defective in rpsB gene for ribosomal protein S2%3B interacts with the Poly(A) polymerase%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%2C DEAD box subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_40 ZOBELLIA_400 ZOBELLIA_400 ZOBELLIA_400 536307 536978 + Peptidase%2C family C40 Cysteine peptidase belonging to the family C40. Its exact function is not known. C40 peptidases contain single conserved cysteine and histidine residues that form a catalytic dyad in the order Cys%2C His. Features a prokaryotic lipoprotein signal peptide cleaved between the residues 27 and 28%3B Localized in the outer membrane%3B~Specificity unclear gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_400 ZOBELLIA_4000 ZOBELLIA_4000 norM2 norM2 4708925 4710334 + Multidrug resistance protein Multidrug efflux pump that functions probably as a Na(+)/drug antiporter%3B Contains 12 transmembrane segments%3B Belongs to the multi antimicrobial extrusion (MATE) family%2C MdtK subfamily%3B Localize in the cytoplasmic membrane%3B~Specificity unclear gene gene4000 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4000 ZOBELLIA_4001 ZOBELLIA_4001 metC metC 4710375 4711550 + Cystathionine beta-lyase Cystathionine beta-lyase (CBL) is found in the Selenoamino acids metabolism pathway and in methionine and cysteine biosynthesis pathways. It converts (seleno)cystathionine to (seleno)homocysteine but is also able to catalyze an alpha%2C gamma elimination%3B Uses a pyridoxal phosphate group as cofactor%2C attached to a lysine residue located in the central section of the enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4001 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4001 ZOBELLIA_4002 ZOBELLIA_4002 ZOBELLIA_4002 4711592 4712314 + Carbohydrate esterase%2C family CE14 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 14 of the carbohydrate esterases (CE14)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4002 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4002 ZOBELLIA_4003 ZOBELLIA_4003 ZOBELLIA_4003 4712311 4714401 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains five N-terminal tetratrico peptide repeats (TPR) and two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4003 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4003 ZOBELLIA_4005 ZOBELLIA_4005 ZOBELLIA_4005 4714827 4715813 - Transposase%2C family 12 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 12 of transposases family%3B Localized in the cytoplasm%3B~Family membership gene gene4005 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4005 ZOBELLIA_4006 ZOBELLIA_4006 ZOBELLIA_4006 4715800 4716153 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4006 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4006 ZOBELLIA_4007 ZOBELLIA_4007 ZOBELLIA_4007 4716270 4717838 - Metallopeptidase%2C family M28 Family M28 contains aminopeptidases and carboxypeptidases with two co-catalytic zinc ions. Each zinc ion is tetrahedrally co-ordinated%2C with three amino acid ligands plus activated water%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Specificity unclear gene gene4007 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4007 ZOBELLIA_4008 ZOBELLIA_4008 mroA4 mroA4 4717990 4719177 + Aldose 1-epimerase Aldose 1-epimerase or Mutarotase is responsible for the anomeric interconversion of aldoses between their alpha- and beta-forms%3B It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B localized in the outer membrane%3B~High confidence in function and specificity gene gene4008 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4008 ZOBELLIA_4009 ZOBELLIA_4009 ZOBELLIA_4009 4719174 4720046 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons. Contains a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization and two C-terminal AraC- type HTH DNA-binding domains involved in the binding of the protein to the operator sequences in the DNA. Localized in the cytoplasm.%3B~Family membership gene gene4009 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4009 ZOBELLIA_401 ZOBELLIA_401 ZOBELLIA_401 536979 537884 + Conserved hypothetical protein Localized in the cytoplasm. gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_401 ZOBELLIA_4010 ZOBELLIA_4010 dapA1 dapA1 4720189 4721127 + Dihydrodipicolinate synthetase Dihydropicolinate synthase (DHDPS) is the key enzyme in lysine biosynthesis via the diaminopimelate pathway of prokaryotes%2C some phycomycetes and higher plants. The enzyme catalyses the condensation of L- aspartate-beta-semialdehyde and pyruvate to dihydropicolinic acid via a ping-pong mechanism in which pyruvate binds to the enzyme by forming a Schiff-base with a lysine residue%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene4010 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4010 ZOBELLIA_4011 ZOBELLIA_4011 aldH aldH 4721294 4722880 + NADP-dependent fatty aldehyde dehydrogenase Catalyzes the oxidation of long-chain aliphatic aldehydes to acids.%2C Aldehyde dehydrogenases are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor%3B located in the cytoplasm%3B~High confidence in function and specificity gene gene4011 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4011 ZOBELLIA_4012 ZOBELLIA_4012 ZOBELLIA_4012 4722911 4723918 + Proline racemase Proline racemase catalyzes the interconversion of L-and D-proline. It forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4012 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4012 ZOBELLIA_4013 ZOBELLIA_4013 dadA dadA 4723932 4725182 + D-amino acid dehydrogenase D-amino acid dehydrogenase is involved in D-amino acids degradation. It converts a D-amino acid to a 2-oxo acid and ammoniac%3B Binds a FAD as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4013 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4013 ZOBELLIA_4014 ZOBELLIA_4014 cydA cydA 4725295 4726674 + Cytochrome d ubiquinol oxidase subunit I Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at low aeration. It catalyzes the reaction: Ubiquinol-8 + O2 %3D Ubiquinone-8 + H2O. It is a heterodimer of subunits I and II. Binds 3 heme groups per dimer. Contains the protoheme IX center b595 and one iron-chlorin (heme D). Features nine transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4014 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4014 ZOBELLIA_4015 ZOBELLIA_4015 cydB cydB 4726681 4727718 + Cytochrome d ubiquinol oxidase subunit II Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at low aeration. It catalyzes the reaction: Ubiquinol-8 + O2 %3D Ubiquinone-8 + H2O. It is a heterodimer of subunits I and II. Binds 3 heme groups per dimer. Contains the protoheme IX center b595 and one iron-chlorin (heme D). Features nine transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4015 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4015 ZOBELLIA_4016 ZOBELLIA_4016 ZOBELLIA_4016 4727726 4728115 - Glyoxalase superfamily protein Conserved protein belonging to the Glyoxalase superfamily%2C which includes Glyoxalase I (lactoylglutathione lyase)%2C but also Bleomycin resistance protein and various dioxygenases. Localized in the cytoplasm.%3B~Family membership gene gene4016 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4016 ZOBELLIA_4017 ZOBELLIA_4017 ZOBELLIA_4017 4728112 4728690 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4017 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4017 ZOBELLIA_4018 ZOBELLIA_4018 ZOBELLIA_4018 4728687 4729334 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4018 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4018 ZOBELLIA_4019 ZOBELLIA_4019 ZOBELLIA_4019 4729390 4729833 + Esterase Conserved esterase belonging to the thioesterase superfamily. Its specificity is unknown. Localized in the cytoplasm.%3B~Specificity unclear gene gene4019 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4019 ZOBELLIA_402 ZOBELLIA_402 ZOBELLIA_402 537891 538757 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_402 ZOBELLIA_4020 ZOBELLIA_4020 menF menF 4729833 4730948 + Menaquinone-specific isochorismate synthase The isochorismate synthase%2C called also isochorismate mutase catalyses the conversion of chorismate to isochorismate%2C the first step in the biosynthesis of both respiratory chain components: menaquinone (MK%2C vitamin K2) and phylloquinone (vitamin K1)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4020 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4020 ZOBELLIA_4021 ZOBELLIA_4021 menD menD 4730989 4732767 + 2-oxoglutarate decarboxylase/SHCHC synthase The 2-oxoglutarate decarboxylase/SHCHC synthase is a thiamine pyrophosphate bifunctional enzyme involved in the second step of the menaquinone biosynthesis pathway from chorismate. It displays a 2-oxoglutarate decarboxylase activity (alpha-ketoglutarate decarboxylase%3B KDC) and a 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1- carboxylate synthase (SHCHC) activity%3B Uses the thiamine pyrophosphate (vitamin B1) and the magnesium ion as cofactors%3B Belongs to the Thiamine Pyrophosphte enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4021 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4021 ZOBELLIA_4022 ZOBELLIA_4022 ZOBELLIA_4022 4732797 4733135 + Conserved hypothetical protein Localized in the cytoplasm gene gene4022 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4022 ZOBELLIA_4023 ZOBELLIA_4023 ZOBELLIA_4023 4733218 4734048 + Conserved hypothetical protein Seems to contains a C-terminal OB motif involved in the oligonucleotide/oligosaccharide binding%3B Localized in the cytoplasm gene gene4023 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4023 ZOBELLIA_4024 ZOBELLIA_4024 ZOBELLIA_4024 4734235 4734834 + Conserved hypothetical protein Protein with a simple bitopic topology: a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain that could be involved in the cell division%3B Contains a central transmembrane segments%3B Localized in the cytoplasmic membrane gene gene4024 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4024 ZOBELLIA_4025 ZOBELLIA_4025 menA menA 4734837 4735745 + 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase Converts the 1%2C4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK)%2C the seventh step in the menaquinone (vitamin K2) biosynthesis pathway from chorismate%3B The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2)%2C the attachment of the isoprenoid side chain%2C and a quinol-to-quinone oxidation%2C which is thought to be spontaneous. Attaches octaprenylpyrophosphate%2C a membrane-bound 40-carbon side chain to DHNA%3B Contains eight transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4025 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4025 ZOBELLIA_4026 ZOBELLIA_4026 ZOBELLIA_4026 4735780 4736532 + two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C which acts as transcriptional regulator%3B Localized in the cytoplasm%3B~Family membership gene gene4026 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4026 ZOBELLIA_4027 ZOBELLIA_4027 ZOBELLIA_4027 4737110 4739107 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments and three N-terminal tetratrico peptide repeats (TPR)%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4027 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4027 ZOBELLIA_4028 ZOBELLIA_4028 ZOBELLIA_4028 4739094 4739270 - Conserved hypothetical protein Possible fragment of 3-oxoacyl-[acyl-carrier protein] reductase%3B Putatively localized in the cytoplasm gene gene4028 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4028 ZOBELLIA_4029 ZOBELLIA_4029 menC menC 4739402 4740454 + O-succinylbenzoate synthase Enzyme involved in the third step of the menaquinone biosynthesis pathway from the chorismate. It converts the 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1- carboxylate (SHCHC) to O-succinylbenzoate (OSB)%3B Uses the magnesium ion as cofactor%3B Belongs to the mandelate racemase/muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4029 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4029 ZOBELLIA_403 ZOBELLIA_403 ZOBELLIA_403 538768 539910 + Conserved hypothetical protein Localized in the cytoplasm gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_403 ZOBELLIA_4030 ZOBELLIA_4030 ZOBELLIA_4030 4740445 4741428 + Peptidase%2C family U48 Conserved peptidase belonging to the family U48%2C which includes prenyl peptidases. Its exact specificity is unknown. Features eight transmembrane helices. Localized in the cytoplasmic membrane.%3B~Function unclear gene gene4030 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4030 ZOBELLIA_4031 ZOBELLIA_4031 menE menE 4741394 4742485 + O-succinylbenzoic acid-CoA ligase the O-succinylbenzoic acid-CoA ligase converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA) in the fourth step of the menaquinone (vitamin K2) biosynthesis pathway from chorismate%3B Contains an AMP-binding domain%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4031 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4031 ZOBELLIA_4032 ZOBELLIA_4032 mccB mccB 4742508 4744136 - Methylcrotonoyl-CoA carboxylase beta chain Methylcrotonoyl-CoA carboxylase is involved in leucine catabolism. It catalyzes the reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- %3D ADP + phosphate + 3-methylglutaconyl-CoA. It forms a dodecamer composed of six biotin-containing alpha subunits and six beta subunits. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4032 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4032 ZOBELLIA_4033 ZOBELLIA_4033 ZOBELLIA_4033 4744210 4745208 + NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family%3B Adopts a Rossmann fold%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4033 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4033 ZOBELLIA_4034 ZOBELLIA_4034 ZOBELLIA_4034 4745268 4745450 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4034 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4034 ZOBELLIA_4035 ZOBELLIA_4035 ZOBELLIA_4035 4745493 4747184 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Contains a duplicated ATPase domain%3B Belongs to the ABC transporter family%2C EF3 subfamily%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with a membrane permease component%3B~Family membership gene gene4035 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4035 ZOBELLIA_4036 ZOBELLIA_4036 ZOBELLIA_4036 4747257 4748075 - Metallo-beta-lactamase superfamily protein Protein belonging to the zinc-dependent beta-lactamase superfamily. This superfamily contains various metallo-hydrolases including beta-lactamases%2C but also glyoxylases and arylsulfatases. The active site is characterized by several conserved histidines binding one or two catalytic zinc ions%3B Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Family membership gene gene4036 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4036 ZOBELLIA_4037 ZOBELLIA_4037 ZOBELLIA_4037 4748088 4748543 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4037 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4037 ZOBELLIA_4038 ZOBELLIA_4038 ZOBELLIA_4038 4748712 4749599 + Conserved hypothetical membrane protein Contains an uncleaved signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4038 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4038 ZOBELLIA_4039 ZOBELLIA_4039 fumC fumC 4749680 4751113 - Fumarate hydratase%2C class II The fumarate hydratase FumC is involved in the tricarboxylic acid cycle. It catalyzes the reaction: (S)-malate %3D fumarate + H2O. FumC forms a homotetramer. There are 2 substrate binding sites: the catalytic A site%2C and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively%2C the B site may bind allosteric effectors. FumC belongs to the class II of the fumarase/aspartase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4039 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4039 ZOBELLIA_404 ZOBELLIA_404 ZOBELLIA_404 539921 540430 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_404 ZOBELLIA_4040 ZOBELLIA_4040 ZOBELLIA_4040 4751239 4751409 + Conserved hypothetical protein Putatively localized in the cytoplasm. gene gene4040 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4040 ZOBELLIA_4041 ZOBELLIA_4041 ZOBELLIA_4041 4751539 4754037 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (32-116) and the Plug module (132-229) acting as a channel gate%3B The signal peptide is cleaved between the residues 18 and 19%3B~Family membership gene gene4041 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4041 ZOBELLIA_4042 ZOBELLIA_4042 ZOBELLIA_4042 4754039 4754542 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4042 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4042 ZOBELLIA_4043 ZOBELLIA_4043 arsC arsC 4754735 4755076 - Arsenate reductase ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]. Glutaredoxin functions as the electron donor for arsenate reduction. ArsC also uses molybdenum as a cofactor. ArsC expands the substrate specificity of arsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4043 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4043 ZOBELLIA_4044 ZOBELLIA_4044 prfB prfB 4755112 4756098 - Peptide chain release factor 2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. It possess a peptidyl-tRNA hydrolase activity. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4044 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4044 ZOBELLIA_4045 ZOBELLIA_4045 ZOBELLIA_4045 4756351 4757208 - Transglutaminase-like protein Protein belonging to the transglutaminase-like superfamily. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine%2C histidine%2C and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase%3B Localized in the cytoplasm%3B~Family membership gene gene4045 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4045 ZOBELLIA_4046 ZOBELLIA_4046 ZOBELLIA_4046 4757280 4758227 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF403 family%3B Localized in the cytoplasm gene gene4046 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4046 ZOBELLIA_4047 ZOBELLIA_4047 ZOBELLIA_4047 4758302 4759765 - Conserved hypothetical protein Conserved hypothetical protein with two domains of unknown function belonging to the families DUF404 and DUF407%2C respectively%3B Localized in the cytoplasm gene gene4047 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4047 ZOBELLIA_4048 ZOBELLIA_4048 ltaA ltaA 4760011 4761033 + L-allo-threonine aldolase The L-allo-threonine aldolase is an enzyme involved in the Glycine metabolism. It converts the L-allo-Threonine and the threonine to glycine%3B Uses a pyridoxal phosphate group as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4048 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4048 ZOBELLIA_4049 ZOBELLIA_4049 ZOBELLIA_4049 4761035 4761367 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF1508 family%3B Localized in the cytoplasm gene gene4049 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4049 ZOBELLIA_405 ZOBELLIA_405 clpB2 clpB2 540438 542903 + Chaperone ClpB ClpB is a homohexamer that is a part of a stress-induced multi-chaperone system involved in the recovery of the cell from heat-induced damage%2C in cooperation with dnaK%2C dnaJ and grpE. Protein binding stimulates the ATPase activity%3B ATP hydrolysis unfolds the denatured protein aggregates contributing to the solubilization and refolding of denatured protein aggregates by dnaK%3B Contains 2 AAA ATPase domains%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_405 ZOBELLIA_4050 ZOBELLIA_4050 ZOBELLIA_4050 4761562 4762662 + OmpA-like periplasmic protein This conserved protein belongs to the OmpA-like family. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space and/or in the outer membrane%3B~Family membership gene gene4050 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4050 ZOBELLIA_4051 ZOBELLIA_4051 ZOBELLIA_4051 4762712 4763158 - Thioredoxin family protein Conserved protein belonging to the thioredoxin family. Thioredoxins are small proteins of approximately one hundred amino-acid residues which participate in various redox reactions via the reversible oxidation of an active center disulfide bond%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Family membership gene gene4051 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4051 ZOBELLIA_4052 ZOBELLIA_4052 ZOBELLIA_4052 4763200 4763526 - Conserved hypothetical protein Protein of unknown function belonging to the YbaB family (DUF 149)%3B Localized in the cytoplasm%3B~Family membership gene gene4052 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4052 ZOBELLIA_4053 ZOBELLIA_4053 ptrB ptrB 4763592 4765733 + Oligopeptidase B%2C family S9 Oligopeptidase B Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues. The active site residues are in the order Ser%2C Asp%2C His in the sequence%3B Belongs to the family 9 of the serine peptidases (S9)%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene4053 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4053 ZOBELLIA_4054 ZOBELLIA_4054 cysK1 cysK1 4765996 4767039 + Cysteine synthase A The cysteine synthase is the enzyme responsible for the formation of cysteine from O-acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid%3B Uses the pyridoxal phosphate as cofactor (vitamin B6) attached to a conserved lysine residue%3B Belongs to the cysteine synthase/cystathionine beta-synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4054 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4054 ZOBELLIA_4055 ZOBELLIA_4055 kblA3 kblA3 4767164 4768423 + Glycine C-acetyltransferase Enzyme involved in the Glycine%2C serine and threonine metabolism%2C and in particular%2C in the glycine catabolism%3B Also called 2-amino-3-ketobutyrate coenzyme A ligase%3B Uses the Pyridoxal phosphate as cofactor%3B Belongs to the class II of the pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4055 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4055 ZOBELLIA_4056 ZOBELLIA_4056 ZOBELLIA_4056 4768523 4769641 - Conserved hypothetical protein Localized in the cytoplasm gene gene4056 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4056 ZOBELLIA_4057 ZOBELLIA_4057 ZOBELLIA_4057 4769735 4770820 - Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4057 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4057 ZOBELLIA_4058 ZOBELLIA_4058 ZOBELLIA_4058 4771047 4771310 + Conserved hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4058 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4058 ZOBELLIA_4059 ZOBELLIA_4059 ZOBELLIA_4059 4771489 4773945 + Conserved hypothetical membrane protein Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4059 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4059 ZOBELLIA_406 ZOBELLIA_406 ZOBELLIA_406 543087 543521 + Conserved hypothetical protein Localized in the cytoplasm. gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_406 ZOBELLIA_4060 ZOBELLIA_4060 ZOBELLIA_4060 4773984 4775255 + Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm.%3B~Specificity unclear gene gene4060 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4060 ZOBELLIA_4061 ZOBELLIA_4061 ZOBELLIA_4061 4775255 4776718 + Polysaccharide biosynthesis protein Protein involved in the biosynthesis of an unknown exopolysaccharide%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene4061 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4061 ZOBELLIA_4062 ZOBELLIA_4062 ZOBELLIA_4062 4776836 4777618 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4062 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4062 ZOBELLIA_4063 ZOBELLIA_4063 ZOBELLIA_4063 4777672 4778037 + Conserved hypothetical protein Localized in the cytoplasm gene gene4063 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4063 ZOBELLIA_4064 ZOBELLIA_4064 ZOBELLIA_4064 4778053 4780356 + Molybdopterin-containing oxidoreductase%2C alpha subunit Oxydoreductase which consists of a molybdopterin oxydoreductase domain%3B Binds 1 4Fe-4S cluster and uses molybdenum (molybdopterin) as cofactors%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Localized in the cytoplasm%3B~Family membership gene gene4064 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4064 ZOBELLIA_4065 ZOBELLIA_4065 ZOBELLIA_4065 4780611 4780844 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4065 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4065 ZOBELLIA_4066 ZOBELLIA_4066 ZOBELLIA_4066 4780930 4781151 - Putative protein Hypothetical protein gene gene4066 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4066 ZOBELLIA_4067 ZOBELLIA_4067 ZOBELLIA_4067 4781204 4781494 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4067 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4067 ZOBELLIA_4068 ZOBELLIA_4068 uvrA1 uvrA1 4781856 4784633 - Excinuclease ABC%2C subunit A The UvrA protein belongs to the UvrABC repair system responsible of the recognition and processing of DNA lesions%3B UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Contains 2 ABC transporter domains%3B Belongs to the ABC transporter family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4068 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4068 ZOBELLIA_4069 ZOBELLIA_4069 ZOBELLIA_4069 4784879 4785460 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene4069 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4069 ZOBELLIA_407 ZOBELLIA_407 ZOBELLIA_407 543553 545421 + Conserved hypothetical protein Localized in the cytoplasm. gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_407 ZOBELLIA_4070 ZOBELLIA_4070 ZOBELLIA_4070 4785634 4785867 - Putative protein Hypothetical protein gene gene4070 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4070 ZOBELLIA_4071 ZOBELLIA_4071 ZOBELLIA_4071 4786082 4786663 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene4071 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4071 ZOBELLIA_4072 ZOBELLIA_4072 nth nth 4786893 4787555 - Endonuclease III Endonuclease III has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines%2C thymines and guanines. Acts on a damaged strand%2C 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction%2C leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity%2C but which is probably involved in the proper positioning of the enzyme along the DNA strand. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4072 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4072 ZOBELLIA_4073 ZOBELLIA_4073 ZOBELLIA_4073 4787598 4788050 + Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4073 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4073 ZOBELLIA_4074 ZOBELLIA_4074 ZOBELLIA_4074 4788105 4789571 - Conserved hypothetical protein Localized in the cytoplasm gene gene4074 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4074 ZOBELLIA_4075 ZOBELLIA_4075 ZOBELLIA_4075 4789650 4790426 + Metallo-beta-lactamase superfamily protein Conserved protein with a N-terminal domain belonging to the metallo-beta-lactamase superfamily and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue. contains various metallo-hydrolases including beta-lactamases%2C but also glyoxylases and arylsulfatases. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions. Localized in the cytoplasm.%3B~Family membership gene gene4075 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4075 ZOBELLIA_4076 ZOBELLIA_4076 ZOBELLIA_4076 4790449 4790943 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 30 and 31%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4076 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4076 ZOBELLIA_4077 ZOBELLIA_4077 estB estB 4790944 4791603 - Carboxylesterase This carboxylesterase hydrolyzes carboxylic ester bonds with relatively broad substrate specificity. It forms a homodimer. Each subunit consists of a central seven-stranded beta sheet flanked by six alpha helices (alpha/beta hydrolase fold). The structure reveals the catalytic triad Ser-His-Asp. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4077 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4077 ZOBELLIA_4078 ZOBELLIA_4078 ZOBELLIA_4078 4791600 4791923 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4078 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4078 ZOBELLIA_4079 ZOBELLIA_4079 ZOBELLIA_4079 4792013 4792327 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4079 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4079 ZOBELLIA_408 ZOBELLIA_408 ZOBELLIA_408 545524 547359 + Vgr family protein Conserved protein belonging to the Vgr family. The Vgr family proteins are associated with some classes of Rhs elements. Localized in the cytoplasm.%3B~Family membership gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_408 ZOBELLIA_4080 ZOBELLIA_4080 pyrC pyrC 4792353 4793615 - Dihydroorotase Dihydroorotase is involved in Pyrimidine biosynthesis. It catalyzes the reaction: (S)-dihydroorotate + H2O %3D N-carbamoyl-L-aspartate. It forms a homodimer and binds 2 zinc ions per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4080 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4080 ZOBELLIA_4081 ZOBELLIA_4081 ZOBELLIA_4081 4793612 4795561 - Conserved hypothetical membrane protein Membrane protein displaying a domain of unknown function DUF1550%3B Contains two N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4081 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4081 ZOBELLIA_4082 ZOBELLIA_4082 ZOBELLIA_4082 4795642 4796649 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases.%3B~Specificity unclear gene gene4082 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4082 ZOBELLIA_4084 ZOBELLIA_4084 ZOBELLIA_4084 4796992 4797171 - Putative protein Hypothetical protein gene gene4084 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4084 ZOBELLIA_4085 ZOBELLIA_4085 ZOBELLIA_4085 4797244 4798425 + Conserved hypothetical lipoprotein Protein putatively involved in the coordinating multi-protein complex assemblies%3B Contains five WD40 repeats involved in the formation of circularised beta-propeller structure%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4085 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4085 ZOBELLIA_4086 ZOBELLIA_4086 ZOBELLIA_4086 4798464 4799045 + Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Binds 1 4Fe-4S cluster per subunit%3B Localized in the cytoplasm%3B~Family membership gene gene4086 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4086 ZOBELLIA_4087 ZOBELLIA_4087 glcG glcG 4799127 4799624 + Protein glcG The protein GlcG is a conserved protein iniatilly found in the glycolate utilization operon. Its exact function is unknown. Signal peptide cleaved between the residues 25 and 26. Localized in the periplasmic space.%3B~Function unclear gene gene4087 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4087 ZOBELLIA_4088 ZOBELLIA_4088 ZOBELLIA_4088 4799639 4801159 + Hypothetical periplasmic protein Contains a C-terminal stress responsive alpha-beta barrel domain%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4088 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4088 ZOBELLIA_4089 ZOBELLIA_4089 ZOBELLIA_4089 4801253 4801717 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4089 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4089 ZOBELLIA_409 ZOBELLIA_409 ZOBELLIA_409 547372 548232 + Hypothetical protein Putatively localized in the cytoplasm. gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_409 ZOBELLIA_4090 ZOBELLIA_4090 ZOBELLIA_4090 4801909 4802307 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4090 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4090 ZOBELLIA_4091 ZOBELLIA_4091 czcA czcA 4802387 4806718 + Cation efflux transporter Integral membrane protein possibly involved in cobalt%2C zinc and cadmium resistance that belongs to the acrB/acrD/acrF family%3B Contains 13 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2%2C and helices 7 and 8%3B Contains a C-terminal extension of 430 residues after the last transmembrane segment. The three transmembrane domains form a large%2C 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4091 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4091 ZOBELLIA_4092 ZOBELLIA_4092 czcB czcB 4806729 4807877 + cation efflux system protein Possibly involved in the cobalt%2C zinc and cadmium resistance%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters or a multidrug efflux transporter%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Anchored in the cytoplasmic membrane by a N- terminal lipidic residue%3B~Family membership gene gene4092 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4092 ZOBELLIA_4093 ZOBELLIA_4093 ZOBELLIA_4093 4807925 4808800 - Conserved hypothetical protein Localized in the cytoplasm gene gene4093 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4093 ZOBELLIA_4094 ZOBELLIA_4094 ZOBELLIA_4094 4808871 4809269 - Conserved hypothetical protein protein of unknown function Localized in the cytoplasm gene gene4094 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4094 ZOBELLIA_4095 ZOBELLIA_4095 ZOBELLIA_4095 4809446 4810303 + Xylose isomerase-like TIM barrel protein Conserved protein belonging to the Xylose isomerase-like TIM barrel family%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Family membership gene gene4095 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4095 ZOBELLIA_4096 ZOBELLIA_4096 ZOBELLIA_4096 4810534 4812918 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-92) and the Plug module (129-231) acting as a channel gate%3B The signal peptide is cleaved between the residues 18 and 19%3B~Family membership gene gene4096 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4096 ZOBELLIA_4097 ZOBELLIA_4097 ZOBELLIA_4097 4812956 4814110 + Conserved hypothetical membrane protein Contains four PepSY-associated transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4097 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4097 ZOBELLIA_4098 ZOBELLIA_4098 ZOBELLIA_4098 4814307 4814666 + Conserved hypothetical protein Localized in the cytoplasm gene gene4098 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4098 ZOBELLIA_4099 ZOBELLIA_4099 ZOBELLIA_4099 4814768 4815334 + Thiol-disulfide oxidoreductase Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Contains a N-terminal transmembrane helix%3B Belongs to the thioredoxin family%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene4099 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4099 ZOBELLIA_41 ZOBELLIA_41 ZOBELLIA_41 41329 42117 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_41 ZOBELLIA_410 ZOBELLIA_410 ZOBELLIA_410 548250 548738 + Conserved hypothetical protein Localized in the cytoplasm. gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_410 ZOBELLIA_4100 ZOBELLIA_4100 ZOBELLIA_4100 4815356 4815751 - Conserved membrane protein Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4100 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4100 ZOBELLIA_4101 ZOBELLIA_4101 ZOBELLIA_4101 4815848 4816825 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4101 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4101 ZOBELLIA_4102 ZOBELLIA_4102 ZOBELLIA_4102 4816842 4817606 - Conserved hypothetical protein Localized in the cytoplasm gene gene4102 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4102 ZOBELLIA_4103 ZOBELLIA_4103 ZOBELLIA_4103 4817639 4818331 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B~Family membership gene gene4103 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4103 ZOBELLIA_4104 ZOBELLIA_4104 ZOBELLIA_4104 4818404 4818553 + Putative protein Hypothetical protein gene gene4104 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4104 ZOBELLIA_4105 ZOBELLIA_4105 folE2 folE2 4818540 4819139 + GTP cyclohydrolase I GTP cyclohydrolase I catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate. FolE is a homodecamer%2C composed of a dimer of pentamers. It is an allosteric enzyme%2C whose activity is modulated by K(+)%2C divalent cations%2C UTP%2C and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4105 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4105 ZOBELLIA_4106 ZOBELLIA_4106 ZOBELLIA_4106 4819219 4819524 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4106 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4106 ZOBELLIA_4107 ZOBELLIA_4107 suoX suoX 4819808 4821028 + Sulfite oxidase Sulfite oxidase catalyzes oxidation of sulphite to sulphate%2C using cytochrome c as the physiological electron acceptor. It forms a homodimer and the monomer consists of an N-terminal heme domain%2C Contains a twin arginine translocation pathway signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasm%3B~High confidence in function and specificity gene gene4107 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4107 ZOBELLIA_4108 ZOBELLIA_4108 ZOBELLIA_4108 4821029 4821517 + Conserved hypothetical protein Localized in the cytoplasm gene gene4108 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4108 ZOBELLIA_4109 ZOBELLIA_4109 ZOBELLIA_4109 4821563 4822459 + Fatty acid hydroxylase family protein Conserved protein belonging to the Fatty acid hydroxylase family. Members of this family are involved in cholesterol biosynthesis%3B Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4109 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4109 ZOBELLIA_411 ZOBELLIA_411 ZOBELLIA_411 548739 550994 + Hypothetical protein Putatively localized in the cytoplasm. gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_411 ZOBELLIA_4110 ZOBELLIA_4110 ZOBELLIA_4110 4822504 4824723 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-101) and the Plug module (116-221) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene4110 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4110 ZOBELLIA_4111 ZOBELLIA_4111 ZOBELLIA_4111 4824777 4825106 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4111 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4111 ZOBELLIA_4112 ZOBELLIA_4112 ZOBELLIA_4112 4825159 4825461 - Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4112 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4112 ZOBELLIA_4113 ZOBELLIA_4113 ZOBELLIA_4113 4825489 4825944 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4113 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4113 ZOBELLIA_4114 ZOBELLIA_4114 ZOBELLIA_4114 4826049 4826681 - Conserved hypothetical protein Localized in the cytoplasm gene gene4114 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4114 ZOBELLIA_4115 ZOBELLIA_4115 serA2 serA2 4826961 4827911 - D-3-phosphoglycerate dehydrogenase SerA catalyzes the conversion of 3-phosphoglycerate to 3-phosphonooxypyruvate%2C which is the first step of the serine biosynthesis pathway. SerA2 is composed of a substrate-binding domain (D-isomer specific 2-hydroxyacid dehydrogenase family) and a NAD-binding domain (Rossman fold). Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4115 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4115 ZOBELLIA_4116 ZOBELLIA_4116 serC serC 4828018 4829082 - Phosphoserine aminotransferase Phosphoserine aminotransferase catalyzes the conversion of O-phospho-L-serine and oxoglutarate to 3-phosphonooxypyruvate and L-glutamate in the the major phosphorylated L-serine biosynthesis pathway%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4116 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4116 ZOBELLIA_4117 ZOBELLIA_4117 ZOBELLIA_4117 4829159 4830199 - Conserved hypothetical protein Localized in the cytoplasm gene gene4117 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4117 ZOBELLIA_4118 ZOBELLIA_4118 fdx fdx 4830330 4830683 + Ferredoxin Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. It binds two 4Fe-4S clusters%3B Localized in the cytoplasm%3B~Function unclear gene gene4118 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4118 ZOBELLIA_4119 ZOBELLIA_4119 ZOBELLIA_4119 4830836 4834108 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (131-204)%2C and a Plug module (221-343) acting as the channel gate%3B The signal peptide is cleaved between the residue 23 and 24%3B~Family membership gene gene4119 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4119 ZOBELLIA_412 ZOBELLIA_412 ZOBELLIA_412 550998 551618 + Conserved hypothetical protein Localized in the cytoplasm. gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_412 ZOBELLIA_4120 ZOBELLIA_4120 ZOBELLIA_4120 4834129 4835124 - anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene4120 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4120 ZOBELLIA_4121 ZOBELLIA_4121 ZOBELLIA_4121 4835181 4835759 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene4121 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4121 ZOBELLIA_4122 ZOBELLIA_4122 engD engD 4836041 4837135 + GTP-dependent nucleic acid-binding protein EngD GTP-dependent nucleic acid-binding protein which may act as a translation factor%3B Uses magnesium ions as cofactor%3B Contains an N-terminal GTPase domain and a C-terminal TGS domain possibly involved in the nucleic acid binding%3B Belongs to the GTP1/OBG family%2C EngD subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4122 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4122 ZOBELLIA_4123 ZOBELLIA_4123 uvrD uvrD 4837346 4839673 + ATP-dependent DNA helicase DNA helicase unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair%3B Contains a uvrD-like helicase ATP-binding domain and a uvrD-like helicase C-terminal domain%3B Belongs to the helicase family%2C UvrD subfamily Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4123 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4123 ZOBELLIA_4124 ZOBELLIA_4124 ZOBELLIA_4124 4839872 4840492 + YrdC family protein Conserved protein belonging to the YrdC family . The YrdC protein from E. coli forms an alpha/beta twisted open-sheet structure composed of seven alpha helices and seven beta strands. YrdC was shown to binds double-stranded RNA. Its exact function is unclear. Localized in the cytoplasm.%3B~Function unclear gene gene4124 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4124 ZOBELLIA_4125 ZOBELLIA_4125 ZOBELLIA_4125 4840517 4841323 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4125 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4125 ZOBELLIA_4126 ZOBELLIA_4126 nagA nagA 4841477 4842874 + Alpha-N-acetylgalactosaminidase%2C family GH109 Alpha-N-acetylgalactosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. This enzyme belongs to the family 109 of the glycoside hydrolases. This hydrolase has an unusual catalytic mechanism involving NAD+ and Mn2+. The protein consists of two closely-associated domains. The N-terminal domain forms a NAD-binding Rossman fold. The C-terminal domain is the substrate-binding domain and adopts a alpha/beta fold. Features a twin-arginine signal peptide cleaved between the residues 28 and 29. Localized in the periplasm.%3B~High confidence in function and specificity gene gene4126 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4126 ZOBELLIA_4127 ZOBELLIA_4127 ZOBELLIA_4127 4842993 4844150 + von Willebrand factor type A protein Conserved protein containing a von Willebrand factor type A (vWF) domain. vWF domains adopt a classic alpha/beta Rossmann fold and usually contains an unusual metal ion coordination site at its surface. Its exact function is unknown. Localized in the cytoplasm.%3B~Family membership gene gene4127 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4127 ZOBELLIA_4128 ZOBELLIA_4128 ZOBELLIA_4128 4844221 4845690 + Conserved hypothetical protein Conserved protein belonging to the Magnesium chelatase%2C subunit ChlI family. Its function is unknown. Localized in the cytoplasm. gene gene4128 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4128 ZOBELLIA_4129 ZOBELLIA_4129 ZOBELLIA_4129 4845762 4847126 - Kelch repeats protein This conserved protein displays a N-terminal fibronectin type III domain followed by five Kelch repeats. The kelch motif forms a beta sheet and several of these sheets associate to form a beta propeller structure%3B Prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4129 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4129 ZOBELLIA_413 ZOBELLIA_413 ZOBELLIA_413 551626 552399 + Conserved hypothetical protein Localized in the cytoplasm. gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_413 ZOBELLIA_4130 ZOBELLIA_4130 alyA4 alyA4 4847515 4849866 + Alginate lyase%2C family PL6 Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. It belongs to the family 6 of the polysaccharide lyases. Features an uncleaved signal peptide.%3B~High confidence in function and specificity gene gene4130 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4130 ZOBELLIA_4131 ZOBELLIA_4131 alyA5 alyA5 4849883 4850941 + Alginate lyase%2C family PL7 Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends%3B Belongs to the family 7 of the polysaccharide lyases (PL7)%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene4131 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4131 ZOBELLIA_4132 ZOBELLIA_4132 alyA6 alyA6 4851091 4853424 + Alginate lyase%2C family PL6 Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. It belongs to the family 6 of the polysaccharide lyases. Features a signal peptide cleaved between residues 22 and 23. Localized in the periplasm.%3B~High confidence in function and specificity gene gene4132 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4132 ZOBELLIA_4133 ZOBELLIA_4133 ZOBELLIA_4133 4853488 4854981 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments and a HAMP domain%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4133 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4133 ZOBELLIA_4134 ZOBELLIA_4134 ZOBELLIA_4134 4854978 4855679 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity (here a winged-helix DNA-binding domain) that acts as transcriptional regulator%3B~Family membership gene gene4134 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4134 ZOBELLIA_4135 ZOBELLIA_4135 ZOBELLIA_4135 4856065 4856955 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4135 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4135 ZOBELLIA_4136 ZOBELLIA_4136 ZOBELLIA_4136 4857021 4857503 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4136 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4136 ZOBELLIA_4137 ZOBELLIA_4137 truA2 truA2 4858212 4859009 + tRNA pseudouridine synthase A tRNA pseudouridine synthase is responsible for the formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer-RNAs. Pseudouridine is an isomer of uridine (5-(beta-D- ribofuranosyl) uracil%2C and id the most abundant modified nucleoside found in all cellular RNAs. TruA contains one atom of zinc essential for its native conformation and tRNA recognition and has a strictly conserved aspartic acid that is likely to be involved in catalysis. It forms a dimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4138 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4137 ZOBELLIA_4138 ZOBELLIA_4138 ZOBELLIA_4138 4857701 4858213 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4137 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4138 ZOBELLIA_4139 ZOBELLIA_4139 corA corA 4859050 4860141 + Magnesium transport protein CorA CorA is a membrane protein which mediates influx of magnesium ions. It forms a homotetramer. Features two C-terminal transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4139 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4139 ZOBELLIA_414 ZOBELLIA_414 ZOBELLIA_414 552570 553586 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_414 ZOBELLIA_4140 ZOBELLIA_4140 ZOBELLIA_4140 4860215 4861012 + Serine peptidase%2C family S9 Conserved protein belonging to the family S9 of the serine peptidases. The active site residues are in the order Ser%2C Asp%2C His in the sequence. Its exact specificity is unknown. Features a signal peptide cleaved between the residues 22 and 23. Localized in the periplasm.%3B~Specificity unclear gene gene4140 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4140 ZOBELLIA_4141 ZOBELLIA_4141 cysM cysM 4861018 4861902 - Cysteine synthase B The cysteine synthase is the enzyme responsible for the formation of cysteine from O-acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid. Uses the pyridoxal phosphate as cofactor (vitamin B6) attached to a conserved lysine residue. Belongs to the cysteine synthase/cystathionine beta-synthase family%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4141 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4141 ZOBELLIA_4142 ZOBELLIA_4142 cysE cysE 4861892 4862686 - Serine O-acetyltransferase Serine O-acetyltransferase is involved in L-cyteine biosynthesis. It catalyzes the reaction: Acetyl-CoA + L-serine %3D CoA + O-acetyl-L-serine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4142 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4142 ZOBELLIA_4143 ZOBELLIA_4143 ZOBELLIA_4143 4862780 4863460 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4143 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4143 ZOBELLIA_4144 ZOBELLIA_4144 ZOBELLIA_4144 4863449 4863886 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4144 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4144 ZOBELLIA_4145 ZOBELLIA_4145 gabD gabD 4864010 4865365 + Succinate-semialdehyde dehydrogenase Aldehyde dehydrogenases are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor.A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this family.Located in the cytoplasm.%3B~Family membership gene gene4145 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4145 ZOBELLIA_4146 ZOBELLIA_4146 ZOBELLIA_4146 4865606 4866205 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4146 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4146 ZOBELLIA_4147 ZOBELLIA_4147 ZOBELLIA_4147 4866229 4866324 - Putative protein Hypothetical protein gene gene4147 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4147 ZOBELLIA_4148 ZOBELLIA_4148 ZOBELLIA_4148 4866347 4867243 + DUF72 family protein Conserved protein belonging to the DUF72 family. Localized in the cytoplasm.%3B~Family membership gene gene4148 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4148 ZOBELLIA_4149 ZOBELLIA_4149 yciA yciA 4867301 4867696 + Acyl-CoA thioester hydrolase yciA Acyl-CoA thioester hydrolase yciA catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4149 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4149 ZOBELLIA_415 ZOBELLIA_415 ZOBELLIA_415 553635 553865 + LemA family protein%2C N-terminal fragment Hypothetical protein%3B~Family membership gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_415 ZOBELLIA_4150 ZOBELLIA_4150 ZOBELLIA_4150 4867693 4869024 - Dipeptidase%2C family M19 Dipeptidase hydrolyzes a wide range of dipeptides. Binds two catalytic zinc ions%3B Belongs to the family M19 of the peptidases%3B Contains a putative lipoprotein signal peptide cleaved between the residues 29 and 30%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene4150 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4150 ZOBELLIA_4151 ZOBELLIA_4151 ZOBELLIA_4151 4869176 4869907 + Histidine-containing phosphotransfer protein Histidine-containing phosphotransfer (HPt)protein mediates phosphotransfer reactions in the two-component signaling systems. Such a protein consists of six alpha helices containing a four-helix bundle-folding. Localized in the cytoplasm.%3B~Specificity unclear gene gene4151 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4151 ZOBELLIA_4152 ZOBELLIA_4152 ZOBELLIA_4152 4869916 4870287 + Response regulator receiver This protein is a isolated response regulator receiver which is phosphorytaled by an histidine protein kinase environmental sensor. Belongs to the CheY family. Localized in the cytoplasm.%3B~Specificity unclear gene gene4152 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4152 ZOBELLIA_4153 ZOBELLIA_4153 ZOBELLIA_4153 4870289 4873087 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4153 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4153 ZOBELLIA_4154 ZOBELLIA_4154 ZOBELLIA_4154 4873080 4874510 + Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. It is closely related to PgaC (Biofilm PGA synthesis N-glycosyltransferase) which is involved in E. coli in the biosynthesis of an exopolysaccharide constituted of N-acetyl-D-glucosamines linked by beta-(1%2C6) glycosidic bonds. Integral membrane protein with five transmembrane helices.%3B~Specificity unclear gene gene4154 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4154 ZOBELLIA_4155 ZOBELLIA_4155 ZOBELLIA_4155 4874519 4876876 + Hypothetical membrane protein Protein that could belong to the akaline phosphatase superfamily%3B Contains five N-terminal transmembrane segments and three C-terminal TPR repeats involved in proteinprotein interactions and the assembly of multiprotein complexes%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4155 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4155 ZOBELLIA_4156 ZOBELLIA_4156 ZOBELLIA_4156 4876903 4878180 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4156 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4156 ZOBELLIA_4157 ZOBELLIA_4157 ZOBELLIA_4157 4878599 4878697 + Conserved hypothetical protein Localized in the cytoplasm. gene gene4157 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4157 ZOBELLIA_4158 ZOBELLIA_4158 rpoD2 rpoD2 4878919 4879782 - RNA polymerase sigma factor rpoD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. RpoD is usually the primary sigma factor in bacteria. Belongs to the sigma-70 factor family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4158 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4158 ZOBELLIA_4159 ZOBELLIA_4159 ZOBELLIA_4159 4879954 4880463 + Conserved hypothetical protein Localized in the cytoplasm gene gene4159 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4159 ZOBELLIA_416 ZOBELLIA_416 ZOBELLIA_416 553823 554194 + LemA family protein%2C C-terminal fragment Conserved hypothetical protein%3B~Family membership gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_416 ZOBELLIA_4160 ZOBELLIA_4160 ghrA ghrA 4880466 4881395 + Glyoxylate/hydroxypyruvate reductase A Glyoxylate/hydroxypyruvate reductase A catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate%2C respectively%3B Contains a glycine-rich region located in the central section corresponding to the NAD-binding domain%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4160 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4160 ZOBELLIA_4161 ZOBELLIA_4161 ZOBELLIA_4161 4881595 4883106 + ATP-dependent helicase Helicases are involved in unwinding nucleic acids%3B Contains a N-terminal ResIII domain or a DEAD domain and a C-terminal helicase domain%3B Belongs to the superfamily II of helicases%3B Localized in the cytoplasm%3B~Family membership gene gene4161 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4161 ZOBELLIA_4162 ZOBELLIA_4162 ZOBELLIA_4162 4883151 4884395 + Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds%3B Belongs to the family 4 of the glycosyltransferases (GT4)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4162 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4162 ZOBELLIA_4163 ZOBELLIA_4163 ZOBELLIA_4163 4884428 4884826 - Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene4163 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4163 ZOBELLIA_4164 ZOBELLIA_4164 ZOBELLIA_4164 4884841 4887081 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene4164 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4164 ZOBELLIA_4165 ZOBELLIA_4165 ZOBELLIA_4165 4887203 4887601 - Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene4165 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4165 ZOBELLIA_4166 ZOBELLIA_4166 ZOBELLIA_4166 4887608 4890229 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains three N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene4166 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4166 ZOBELLIA_4167 ZOBELLIA_4167 menB menB 4890577 4891425 + Naphthoate synthase Also called dihydroxynaphthoic acid synthetase (DHNA)%2C this enzyme converts the O-succinylbenzoyl-CoA (OSB-CoA) to 1%2C4-dihydroxy-2-naphthoic acid (DHNA) in the fifth step of the menaquinone (vitamin K2) biosynthesis pathway from chorismate%3B Belongs to the enoyl-CoA hydratase/isomerase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4167 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4167 ZOBELLIA_4168 ZOBELLIA_4168 ZOBELLIA_4168 4891707 4893035 - Serine peptidase%2C family S12 Protein belonging to the family 12 of Serine peptidases (S12). Could be a beta-lactamase classified as S12 non-peptidase homologues. However%2C the active site residues Ser and Lys that form the catalytic dyad are found in the motif Ser-Xaa-Thr-Lys%3B Contains a N-terminal transmembrane segment and a C-terminal beta-lactamase domain%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene4168 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4168 ZOBELLIA_4169 ZOBELLIA_4169 gyaR gyaR 4893133 4894092 + Glyoxylate reductase Glyoxylate reductase converts%2C in presence of NAD+%2C the Glycolate into glyoxylate. GyaR is involved in the glyoxylate metabolism (conversion of lipids into glucids)%3B Contains a glycine-rich region located in the central section corresponding to the NAD-binding domain%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4169 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4169 ZOBELLIA_417 ZOBELLIA_417 ZOBELLIA_417 554130 554540 + Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_417 ZOBELLIA_4170 ZOBELLIA_4170 ZOBELLIA_4170 4894126 4894554 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4170 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4170 ZOBELLIA_4171 ZOBELLIA_4171 ZOBELLIA_4171 4894551 4895249 + Amidase Amidase catalyzes the reaction: a monocarboxylic acid amide + H2O %3D a monocarboxylate + NH3. The specificity of this enzyme is unknown. Belongs to a protein family including N-acetylmuramoyl-L-alanine amidase. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene4171 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4171 ZOBELLIA_4172 ZOBELLIA_4172 ZOBELLIA_4172 4895246 4896712 + Metallopeptidase%2C family M14 Peptidase family M14 contains mainly metallocarboxypeptidases. The single catalytic zinc ion is tetrahedrally coordinated by two histidines and a glutamate%2C as well as a water molecule. One of the histidines and the glutamate occur in the motif His-Xaa-Xaa-Glu. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm.%3B~Specificity unclear gene gene4172 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4172 ZOBELLIA_4173 ZOBELLIA_4173 ZOBELLIA_4173 4896726 4896929 - Putative membrane protein Contains a transmembrane helix%3B Putatively localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4173 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4173 ZOBELLIA_4174 ZOBELLIA_4174 ZOBELLIA_4174 4897126 4897953 - OmpA-like lipoprotein Protein containing a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Family membership gene gene4174 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4174 ZOBELLIA_4175 ZOBELLIA_4175 ZOBELLIA_4175 4898179 4899264 - von Willebrand factor type A protein Conserved protein containing a von Willebrand factor type A (vWF) domain. vWF domains adopt a classic alpha/beta Rossmann fold and usually contains an unusual metal ion coordination site at its surface. Its exact function is unknown. Features a signal peptide cleaved between the residues 23 and 24. Localized in the periplasm.%3B~Family membership gene gene4175 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4175 ZOBELLIA_4176 ZOBELLIA_4176 iorA iorA 4899556 4900017 + Isoquinoline 1-oxidoreductase alpha subunit Isoquinoline 1-oxidoreductase catalyzes the hydroxylation of isoquinoline to 1-oxo-1%2C2-dihydroisoquinoline with subsequent reduction of a suitable electron acceptor utilizing H2O as the source of the oxygen atom incorporated into substrate. It is a heterodimeric molybdo-iron-sulfur protein%2C composed of a small subunit and a large subunit (IorB). IorA binds a [2Fe-2S] cluster as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4176 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4176 ZOBELLIA_4177 ZOBELLIA_4177 iorB iorB 4900078 4902306 + Isoquinoline 1-oxidoreductase beta subunit Isoquinoline 1-oxidoreductase catalyzes the hydroxylation of isoquinoline to 1-oxo-1%2C2-dihydroisoquinoline with subsequent reduction of a suitable electron acceptor utilizing H2O as the source of the oxygen atom incorporated into substrate. It is a heterodimeric molybdo-iron-sulfur protein%2C composed of a small subunit (IorA) and a large subunit . IorB contains a molybdopterin binding domain and an alpha/beta hammerhead domain. Uses molybdopterin as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4177 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4177 ZOBELLIA_4178 ZOBELLIA_4178 ZOBELLIA_4178 4902361 4903371 + XdhC family protein Conserved protein belonging to the XdhC/PucA family. XhdhC in E. coli and PucA in B. subtilis are involved in molybdenum cofactor insertion into xanthine dehydrogenase. Localized in the cytoplasm.%3B~Function unclear gene gene4178 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4178 ZOBELLIA_4179 ZOBELLIA_4179 ZOBELLIA_4179 4903371 4903985 + PucB-like protein Conserved protein%3B~Function unclear gene gene4179 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4179 ZOBELLIA_418 ZOBELLIA_418 ZOBELLIA_418 554548 554652 + Putative protein Hypothetical protein gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_418 ZOBELLIA_4180 ZOBELLIA_4180 ZOBELLIA_4180 4903969 4905054 + Amidohydrolase This protein belongs to the amidohydrolase family. This family is included in the metal-dependent hydrolase superfamily%3B Adopts a TIM-barrel fold%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Family membership gene gene4180 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4180 ZOBELLIA_4181 ZOBELLIA_4181 ZOBELLIA_4181 4905156 4906172 + Metallopeptidase%2C family M4 This peptidase belongs to the family 4 of the metallopeptidases (M4). The conserved catalytic motif is HEXXE%2C in which the histidines are zinc ligands and the glutamate is a catalytic residue. The zinc ion is also bound by a second glutamate%2C 20-33 residues C-terminal to the HEXXH motif%2C and by an activated water molecule which forms the nucleophile in catalysis%3B Possibly localized in the cytoplasm%3B~Specificity unclear gene gene4181 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4181 ZOBELLIA_4182 ZOBELLIA_4182 ZOBELLIA_4182 4906172 4906438 + Putative protein Hypothetical protein gene gene4182 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4182 ZOBELLIA_4183 ZOBELLIA_4183 dhlB dhlB 4906451 4907134 + (S)-2-haloacid dehalogenase Catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isomer of 2- chloropropionic acid with inversion of configuration to produce D-lactate%3B Belongs to the HAD-like hydrolase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4183 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4183 ZOBELLIA_4184 ZOBELLIA_4184 ZOBELLIA_4184 4907141 4907371 - Putative protein Hypothetical protein gene gene4184 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4184 ZOBELLIA_4185 ZOBELLIA_4185 ZOBELLIA_4185 4907556 4908188 - GntR-type transcriptional regulator Transcriptional regulator involved in the repression and/or the positive regulation of genes encoding for enzymes%3B This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcriptional regulators%2C involved in the binding of the protein to the operator sequences in the DNA. At the C-terminus there is an effector- binding/oligomerisation domain%3B Localized in the cytoplasm%3B~Family membership gene gene4185 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4185 ZOBELLIA_4186 ZOBELLIA_4186 ZOBELLIA_4186 4908179 4908334 - Putative protein Hypothetical protein gene gene4186 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4186 ZOBELLIA_4187 ZOBELLIA_4187 ZOBELLIA_4187 4908362 4909189 + Conserved hypothetical protein Localized in the cytoplasm gene gene4187 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4187 ZOBELLIA_4188 ZOBELLIA_4188 cspA4 cspA4 4909644 4910099 + Cold shock protein Cold shock proteins (CSPs) help the cell to survive in temperatures lower than optimum growth temperature. CSPs may act as RNA chaperones by destabilizing RNA secondary structures%2C regulating ribosomal translation%2C rate of mRNA degradation and termination of transcription%3B Contains a 'cold-shock domain' (CSD) involved in the single-strand nucleic-acid binding%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4188 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4188 ZOBELLIA_4189 ZOBELLIA_4189 ZOBELLIA_4189 4910141 4910848 + Conserved hypothetical periplasmic protein Protein belonging to the DUF1080 family%3B Signal peptide cleaved between the residues 30 and 31%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4189 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4189 ZOBELLIA_419 ZOBELLIA_419 ZOBELLIA_419 554789 555691 + Conserved hypothetical protein Conserved protein containing a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_419 ZOBELLIA_4190 ZOBELLIA_4190 rluE rluE 4910854 4911447 - Ribosomal large subunit pseudouridine synthase E Enzyme responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Belongs to the pseudouridine synthase RsuA family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene4190 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4190 ZOBELLIA_4191 ZOBELLIA_4191 ZOBELLIA_4191 4911574 4912203 + NAD dependent epimerase/dehydratase family protein Conserved protein belonging to the NAD dependent epimerase/dehydratase family%3B Localized in the cytoplasm%3B~Family membership gene gene4191 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4191 ZOBELLIA_4192 ZOBELLIA_4192 ZOBELLIA_4192 4912298 4913191 + Xylose isomerase-like TIM barrel protein Conserved protein belonging to the Xylose isomerase-like TIM barrel family%3B Localized in the cytoplasm.%3B~Family membership gene gene4192 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4192 ZOBELLIA_4193 ZOBELLIA_4193 ZOBELLIA_4193 4913202 4914404 + L-sorbosone dehydrogenase L-sorbosone dehydrogenase converts L-sorbosone into 2-keto-L-gulonic acid (2KGA)%3B Uses one of four different quinone as cofactors for the oxidation of sorbosone%3B Belongs to the Quinoprotein dehydrogenases family%3B Lipoprotein with a signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~High confidence in function and specificity gene gene4193 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4193 ZOBELLIA_4194 ZOBELLIA_4194 ZOBELLIA_4194 4914642 4914968 + Putative protein Hypothetical protein gene gene4194 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4194 ZOBELLIA_4195 ZOBELLIA_4195 ZOBELLIA_4195 4915257 4916372 + Conserved hypothetical protein Localized in the cytoplasm gene gene4195 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4195 ZOBELLIA_4196 ZOBELLIA_4196 ZOBELLIA_4196 4916410 4916853 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4196 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4196 ZOBELLIA_4197 ZOBELLIA_4197 ZOBELLIA_4197 4917098 4917799 + Conserved hypothetical protein Localized in the cytoplasm gene gene4197 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4197 ZOBELLIA_4198 ZOBELLIA_4198 ZOBELLIA_4198 4917814 4918683 + Conserved hypothetical protein Localized in the cytoplasm gene gene4198 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4198 ZOBELLIA_4199 ZOBELLIA_4199 ZOBELLIA_4199 4918715 4919317 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4199 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4199 ZOBELLIA_42 ZOBELLIA_42 malS malS 42168 43883 + Alpha-amylase%2C family GH13 Alpha-amylase catalyzes the endohydrolysis of 1%2C4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides. Belongs to the family 13 of the glycoside hydrolases. Involved in starch metabolism. Features an uncleaved signal peptide. Localized into the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_42 ZOBELLIA_420 ZOBELLIA_420 ZOBELLIA_420 555762 555896 + Putative protein Hypothetical protein gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_420 ZOBELLIA_4200 ZOBELLIA_4200 ZOBELLIA_4200 4919547 4919954 + Conserved hypothetical protein Localized in the cytoplasm gene gene4200 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4200 ZOBELLIA_4201 ZOBELLIA_4201 ZOBELLIA_4201 4920036 4921784 + Glycosyde hydrolase%2C family GH9 Possible glycosyde hydrolase belonging to the family 9 of glycoside hydrolases (GH9)%3B Signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Family membership gene gene4201 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4201 ZOBELLIA_4202 ZOBELLIA_4202 ZOBELLIA_4202 4922218 4922568 + Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4202 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4202 ZOBELLIA_4203 ZOBELLIA_4203 agaA agaA 4922793 4924412 - Beta-agarase A%2C family GH16 The beta-agarase A is a modular protein that hydrolyses the 1%2C4-beta-D-galactosidic linkages in agarose%2C giving the tetramer and hexamer as the predominant products%3B Contains a N-terminal catalytic module (20-295) that belongs to the family 16 of glycoside hydrolases (GH16) and two C-terminal domains (296-437 and 438-539) of unknown fuction%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space then secreted in the extracellular medium%3B~High confidence in function and specificity gene gene4203 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4203 ZOBELLIA_4204 ZOBELLIA_4204 ZOBELLIA_4204 4924887 4926974 - MORN repeat protein Conserved protein containing seven MORN repeats%3B Signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Function unclear gene gene4204 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4204 ZOBELLIA_4205 ZOBELLIA_4205 ZOBELLIA_4205 4927255 4927542 + Putative protein Hypothetical protein gene gene4205 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4205 ZOBELLIA_4206 ZOBELLIA_4206 ZOBELLIA_4206 4927646 4930312 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains four N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene4206 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4206 ZOBELLIA_4207 ZOBELLIA_4207 ZOBELLIA_4207 4930389 4930622 + Putative membrane protein contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4207 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4207 ZOBELLIA_4208 ZOBELLIA_4208 ZOBELLIA_4208 4930753 4931106 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4208 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4208 ZOBELLIA_4209 ZOBELLIA_4209 ZOBELLIA_4209 4931246 4931992 + Conserved hypothetical protein Putatively contains a C-terminal Globin-like domain%3B Probably localized in the cytoplasm gene gene4209 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4209 ZOBELLIA_421 ZOBELLIA_421 ZOBELLIA_421 556014 557570 + Conserved hypothetical protein Localized in the cytoplasm. gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_421 ZOBELLIA_4210 ZOBELLIA_4210 ZOBELLIA_4210 4932068 4932643 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Hypothetical protein gene gene4210 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4210 ZOBELLIA_4211 ZOBELLIA_4211 glsA glsA 4932882 4933796 + Glutaminase Glutaminase catalyzes the reaction: L-glutamine + H2O %3D L-glutamate + NH3. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4211 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4211 ZOBELLIA_4212 ZOBELLIA_4212 ZOBELLIA_4212 4934157 4934747 + TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Hypothetical protein gene gene4212 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4212 ZOBELLIA_4213 ZOBELLIA_4213 fabB6 fabB6 4934781 4936046 + 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4213 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4213 ZOBELLIA_4214 ZOBELLIA_4214 ZOBELLIA_4214 4936608 4937249 + Conserved hypothetical protein Localized in the cytoplasm gene gene4214 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4214 ZOBELLIA_4215 ZOBELLIA_4215 ZOBELLIA_4215 4937486 4938097 + Hypothetical protein Putatively localized in the cytoplasm gene gene4215 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4215 ZOBELLIA_4216 ZOBELLIA_4216 ZOBELLIA_4216 4938319 4939371 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Hypothetical protein gene gene4216 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4216 ZOBELLIA_4217 ZOBELLIA_4217 ZOBELLIA_4217 4939620 4940420 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4217 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4217 ZOBELLIA_4218 ZOBELLIA_4218 viuB viuB 4940694 4941419 + Siderophore-interacting protein Siderophore-interacting proteins are involved in intracellular removal of iron from iron-siderophore complex. Induced by iron starvation%3B Contains a N-terminal FAD-binding domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4218 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4218 ZOBELLIA_4219 ZOBELLIA_4219 ZOBELLIA_4219 4941576 4942349 + Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4219 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4219 ZOBELLIA_422 ZOBELLIA_422 ZOBELLIA_422 557570 558640 + Conserved hypothetical protein Localized in the cytoplasm. gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_422 ZOBELLIA_4220 ZOBELLIA_4220 furA2 furA2 4942353 4942727 - Ferric uptake regulation protein Ferric uptake regulation protein is a transcriptional regulator that acts as a global negative controlling element%2C employing Fe(2+) as a cofactor to bind the operator of the repressed metal ion-responsive genes. It regulates the expression of several outer- membrane proteins including the iron transport operon%3B Belongs to the Fur family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4220 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4220 ZOBELLIA_4221 ZOBELLIA_4221 trxB4 trxB4 4942847 4943755 + Thioredoxin reductase The active site of this enzyme is a redox-active disulfide bond. TrxB uses the FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step%2C the reduced disulphide reduces the substrate%3B Acts as an homodimer and binds one FAD molecule per subunit%3B Contains a N-terminal transmembrane segment%3B Belongs to the class 2 of pyridine nucleotide-disulphide reductases (PNDR)%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4221 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4221 ZOBELLIA_4222 ZOBELLIA_4222 ZOBELLIA_4222 4943778 4944023 + Conserved hypothetical protein Localized in the cytoplasm gene gene4222 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4222 ZOBELLIA_4223 ZOBELLIA_4223 ZOBELLIA_4223 4944035 4944637 + SAM-dependent methyltransferase SAM-dependent methyltransferase transfers from the ubiquitous S-adenosyl-L-methionine (SAM) to either nitrogen%2C oxygen or carbon atoms in DNA%2C RNA%2C proteins and small molecules. Its exact specificity is unknown%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4223 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4223 ZOBELLIA_4224 ZOBELLIA_4224 ZOBELLIA_4224 4944799 4945281 + MarR-type transcriptional regulator Transcriptional regulator belonging to the MarR family. Features a helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Family membership gene gene4224 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4224 ZOBELLIA_4225 ZOBELLIA_4225 ZOBELLIA_4225 4945278 4945520 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4225 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4225 ZOBELLIA_4226 ZOBELLIA_4226 ZOBELLIA_4226 4945870 4946433 + Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene4226 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4226 ZOBELLIA_4227 ZOBELLIA_4227 Hrsp12 Hrsp12 4946571 4946990 + Ribonuclease UK114 Ribonuclease UK114 is an endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4227 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4227 ZOBELLIA_4228 ZOBELLIA_4228 ZOBELLIA_4228 4947080 4947757 - Intracellular peptidase%2C family C56 This peptidase belongs to the family 56 of the cysteine peptidases. The catalytic diad is constituted by two consecutive conserved residues%2C Cys His. The enzyme forms a hexameric ring structure%2C and the active sites are proposed to be formed at the interfaces between three pairs of monomers. The peptidase monomer adopts a alpha/beta hydrolase fold. Localized in the cytoplasm.%3B~Specificity unclear gene gene4228 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4228 ZOBELLIA_4229 ZOBELLIA_4229 ZOBELLIA_4229 4947774 4948934 - Iron-containing alcohol dehydrogenase family Contains an Iron-containing alcohol dehydrogenase domain%3B Belongs to the iron-containing alcohol dehydrogenase family%3B Localized in the cytoplasm%3B~Family membership gene gene4229 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4229 ZOBELLIA_423 ZOBELLIA_423 ZOBELLIA_423 558669 558812 + Putative protein Hypothetical protein gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_423 ZOBELLIA_4230 ZOBELLIA_4230 ZOBELLIA_4230 4948964 4949959 - Probable NADP-dependent oxidoreductase Contains an zinc-containing alcohol dehydrogenase superfamily domain%3B Belongs to the NADP-dependent oxidoreductase L4BD family%3B Possibly localized in the cytoplasmic membrane or in the cytoplasm%3B~Family membership gene gene4230 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4230 ZOBELLIA_4231 ZOBELLIA_4231 ZOBELLIA_4231 4949971 4950603 - NAD(P)H-flavin oxidoreductase Belongs to the nitroreductase family. This family include the oxygen-insensitive NAD(P)H nitroreductase (FMN-dependent nitroreductase) (Dihydropteridine reductase) (1.5.1.34) and NADH dehydrogenase (1.6.99.3)%3B Members of this family use FMN as a cofactor%3B Localized in the cytoplasm%3B~Family membership gene gene4231 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4231 ZOBELLIA_4232 ZOBELLIA_4232 ZOBELLIA_4232 4950634 4951212 - TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene4232 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4232 ZOBELLIA_4233 ZOBELLIA_4233 ZOBELLIA_4233 4951412 4951891 + CAZ98368.1 Conserved protein belonging to the GAF family. GAF domains are present in phytochromes and cGMP-specific phosphodiesterases. Localized in the cytoplasm.%3B~Family membership gene gene4233 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4233 ZOBELLIA_4234 ZOBELLIA_4234 ZOBELLIA_4234 4951904 4952665 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4234 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4234 ZOBELLIA_4235 ZOBELLIA_4235 ddc ddc 4952789 4954249 - L-2%2C4-diaminobutyrate decarboxylase L-2%2C4-diaminobutyrate decarboxylase catalyzes the reaction : L-2%2C4-diaminobutanoate %3D propane-1%2C3-diamine + CO2. It is involved in 1%2C3-diaminopropane biosynthesis. This enzyme covalently binds the cofactor pyridoxal-phosphate (PLP) on a conserved lysine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4235 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4235 ZOBELLIA_4236 ZOBELLIA_4236 ZOBELLIA_4236 4954363 4955277 + LysR-type transcriptional regulator Transcriptional regulator belonging to the LysR family. Features a N-terminal helix-turn-helix DNA binding domain and a C-terminal LysR-like substrate binding domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene4236 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4236 ZOBELLIA_4237 ZOBELLIA_4237 ZOBELLIA_4237 4955490 4955975 + Small heat shock protein Heat shock protein belonging to the HSP20 family. Acts as chaperone that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Localized in the cytoplasm.%3B~Family membership gene gene4237 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4237 ZOBELLIA_4238 ZOBELLIA_4238 ZOBELLIA_4238 4956055 4956549 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4238 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4238 ZOBELLIA_4239 ZOBELLIA_4239 ZOBELLIA_4239 4956644 4956787 - Putative protein Hypothetical protein gene gene4239 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4239 ZOBELLIA_424 ZOBELLIA_424 ZOBELLIA_424 558809 559597 - Transposase (pseudogene)%2C family 8 Sequence representing the C-terminal part of transposase that could be an insertion sequence (IS). The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_424 ZOBELLIA_4240 ZOBELLIA_4240 ZOBELLIA_4240 4956917 4957501 + Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~Specificity unclear gene gene4240 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4240 ZOBELLIA_4241 ZOBELLIA_4241 ZOBELLIA_4241 4957517 4958410 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4241 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4241 ZOBELLIA_4242 ZOBELLIA_4242 ZOBELLIA_4242 4958531 4958641 - Putative protein Hypothetical protein gene gene4242 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4242 ZOBELLIA_4243 ZOBELLIA_4243 agaD agaD 4958935 4960368 + Beta-agarase D%2C family GH16 The beta-agarases hydrolyse the 1%2C4-beta-D-galactosidic linkages in agarose%2C giving the tetramer as the predominant product%3B Contains a C-terminal domain of unknown function%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space and possibly secreted in the extracellular medium%3B~High confidence in function and specificity gene gene4243 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4243 ZOBELLIA_4244 ZOBELLIA_4244 ZOBELLIA_4244 4960769 4961068 + Antibiotic biosynthesis monooxygenase family protein Protein Belongs to the antibiotic biosynthesis monooxygenase (ABM) family%3B Localized in the cytoplasm%3B~Family membership gene gene4244 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4244 ZOBELLIA_4245 ZOBELLIA_4245 dpsA3 dpsA3 4961130 4961603 + DNA protection during starvation protein DspA protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions%2C which prevents hydroxyl radical production by the Fenton reaction%3B Forms a homododecamer and the 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4245 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4245 ZOBELLIA_4246 ZOBELLIA_4246 ZOBELLIA_4246 4961626 4962570 + Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene4246 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4246 ZOBELLIA_4247 ZOBELLIA_4247 ZOBELLIA_4247 4962589 4963383 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Possible signal peptide cleaved between the residues 24 and 25%3B Putatively localized in the periplasmic space%3B~Family membership gene gene4247 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4247 ZOBELLIA_4248 ZOBELLIA_4248 alkB2 alkB2 4963465 4964100 + Alpha-ketoglutarate-dependent dioxygenase Alpha-ketoglutarate-dependent dioxygenase repairs alkylated DNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Has a strong preference for single-stranded DNA. May also act on RNA. Requires molecular oxygen%2C alpha-ketoglutarate and iron. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4248 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4248 ZOBELLIA_4249 ZOBELLIA_4249 nfnB2 nfnB2 4964308 4964967 + 6%2C7-dihydropteridine reductase Also called oxygen-insensitive NAD(P)H nitroreductase this enzyme reduces a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents%2C two electrons are transferred. Capable of reducing nitrofurazone%2C quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2%2C4-dinitrobenzamide)%3B Uses the FMN as cofactor%3B Belongs to the nitroreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4249 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4249 ZOBELLIA_425 ZOBELLIA_425 ZOBELLIA_425 559672 559938 - Transposase (pseudogene)%2C family 8 Sequence representing the N-terminal part of transposase that could be an insertion sequence (IS). The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Contains a helix-turn-helix domain%3B Belongs to the family 8 of transposases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_425 ZOBELLIA_4250 ZOBELLIA_4250 qorA2 qorA2 4964992 4965999 + Quinone oxidoreductase The NADP-dependent quinone oxidoreductase catalyzes the one-electron reduction of certain quinones%3B orthoquinones are the best substrates. It is an enzyme found in bacteria%2C in yeast and in mammals where%2C in some species such as rodents%2C it has been recruited as an eye lens protein and is known as zeta-crystallin%3B Belongs to the zinc-containing alcohol dehydrogenase family%2C Quinone oxidoreductase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4250 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4250 ZOBELLIA_4251 ZOBELLIA_4251 ZOBELLIA_4251 4966030 4966497 + Conserved hypothetical protein Contains a C-terminal Cupin domain%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space gene gene4251 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4251 ZOBELLIA_4252 ZOBELLIA_4252 ZOBELLIA_4252 4966499 4967605 + Conserved hypothetical protein Signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space gene gene4252 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4252 ZOBELLIA_4253 ZOBELLIA_4253 ZOBELLIA_4253 4967981 4969534 + ATP-dependent helicase Helicases are involved in unwinding nucleic acids%3B Contains a N-terminal ResIII domain or DEAD domain and a C-terminal helicase domain%3B Belongs to the superfamily II of helicases%3B Localized in the cytoplasm%3B~Family membership gene gene4253 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4253 ZOBELLIA_4254 ZOBELLIA_4254 ZOBELLIA_4254 4969601 4969693 + Putative protein Hypothetical protein gene gene4254 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4254 ZOBELLIA_4255 ZOBELLIA_4255 kefF kefF 4969774 4970379 + K+/H+ antiporter%2C ancillary protein KefF K+/H+ antiporter%2C ancillary protein KefF%2C also called Glutathione-regulated potassium-efflux system ancillary protein is required for full activity of KefC. This ancillary protein stimulates transport activity of KefC about 10-fold. It is unlikely that kefF has oxidoreductase activity%2C it has probably evolved from its function as oxidoreductase to be regulator of kefC%3B Belongs to the NAD(P)H dehydrogenase (quinone) family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4255 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4255 ZOBELLIA_4256 ZOBELLIA_4256 kefC kefC 4970376 4972262 + K(+)/H(+) antiporter The K(+)/H(+) antiporter KefC is a Glutathione-regulated potassium-efflux system protein responsible for glutathione-gated K+ efflux. Activation of KefC K+ efflux system only occurs in the presence of glutathione and a reactive electrophile such as methylglyoxal or N-ethylmaleimide. KefC is important for cell survival during exposure to toxic metabolites%2C possibly because they can release K+%2C allowing H+ uptake. H+ uptake (acidification of the cytoplasm) accompanying or following K+ efflux may serve as a further protective mechanism against electrophile toxicity%3B Contains 12 transmembrane segments and a RCK N-terminal domain%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4256 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4256 ZOBELLIA_4257 ZOBELLIA_4257 ZOBELLIA_4257 4972273 4972599 + Conserved hypothetical protein Protein that consists of an TfoX module found in the N-terminal part of the tfoX gene product required for DNA transformation%3B Localized in the cytoplasm gene gene4257 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4257 ZOBELLIA_4258 ZOBELLIA_4258 ZOBELLIA_4258 4972628 4973359 - NUDIX hydrolase The generic name 'NUDIX hydrolases' corresponds to pyrophosphatases cleaving a NUcleoside DIphosphate linked to some other moiety X. These enzymes hydrolyze diverse nucleoside diphosphate derivatives (including ADP-ribose%2C GDP- mannose%2C TDP-glucose%2C NADH%2C UDP-sugars%2C dNTP and NTP). Localized in the cytoplasm.%3B~Specificity unclear gene gene4258 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4258 ZOBELLIA_4259 ZOBELLIA_4259 ZOBELLIA_4259 4973710 4974501 + Conserved hypothetical protein Probably localized in the cytoplasm gene gene4259 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4259 ZOBELLIA_426 ZOBELLIA_426 ZOBELLIA_426 560146 560250 + Putative protein Hypothetical protein gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_426 ZOBELLIA_4260 ZOBELLIA_4260 rbsB rbsB 4974631 4975692 + Ribose ABC importer%2C periplasmic component RbsB is the D-ribose-binding protein involved in the high-affinity D-ribose membrane transport system%3B Belongs to the bacterial solute-binding protein 2 family%3B Seems to have a uncleavable signal sequence%3B Localized in the cytoplasmic membrane and exposed in the periplasmic space%3B~High confidence in function and specificity gene gene4260 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4260 ZOBELLIA_4261 ZOBELLIA_4261 rbsA rbsA 4975702 4977228 + Ribose ABC importer%2C ATPase component Part of the ABC transporter complex RbsABCD involved in D-ribose import. RbsA is Responsible for energy coupling to the transport system%3B The complex is composed of two ATP-binding proteins%2C two transmembrane proteins (rbsC and rbsD) and a solute-binding protein (rbsB)%3B Contains 2 ABC transporter domains%3B Belongs to the ABC transporter family%2C ribose importer subfamily%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~High confidence in function and specificity gene gene4261 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4261 ZOBELLIA_4262 ZOBELLIA_4262 rbsC rbsC 4977245 4978213 + Ribose ABC importer%2C permease component Part of the binding-protein-dependent ABC transporter system for D-ribose. Probably responsible for the translocation of the substrate across the membrane%3B Contains seven transmembrane segments%3B Belongs to the binding-protein-dependent transport system permease family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4262 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4262 ZOBELLIA_4263 ZOBELLIA_4263 uxuB uxuB 4978227 4979723 + D-mannonate oxidoreductase D-mannonate oxidoreductase or Fructuronate reductase catalyzes the NAD-dependent reduction of fructuronate into mannonate%3B Belongs to the Long-chain mannitol dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4263 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4263 ZOBELLIA_4264 ZOBELLIA_4264 scrK2 scrK2 4979724 4980611 + Fructokinase Fructokinase catalyzes the transfer of a phosphate group from ATP to convert the fructose to fructose-6-phosphate%2C which is an entry point into glycolysis (Embden-Meyerhof pathway) via conversion into glucose-6-phosphate%3B Belongs to the carbohydrate kinase PfkB superfamily%2C bacterial fructokinase family%3B Localized in the cytoplasm%3B~Family membership gene gene4264 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4264 ZOBELLIA_4265 ZOBELLIA_4265 cgiA1 cgiA1 4980692 4982167 - Iota-carrageenase%2C family GH82 The Iota-carrageenases hydrolyse the 1%2C4-beta-D-galactosidic linkages in the iota-carrgeenan giving the tetramer as the predominant product%3B Belongs to the family 82 of glycoside hydrolases (GH82)%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane and possibly secreted in the outside medium%3B~High confidence in function and specificity gene gene4265 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4265 ZOBELLIA_4266 ZOBELLIA_4266 ZOBELLIA_4266 4982249 4982374 - Putative protein Hypothetical protein gene gene4266 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4266 ZOBELLIA_4267 ZOBELLIA_4267 agaC agaC 4982742 4983728 + Beta-agarase C%2C family GH16 The beta-agarases Hydrolyse the 1%2C4-beta-D-galactosidic linkages in agarose%2C giving the tetramer as the predominant product%3B Belongs to the family 16 of glycoside hydrolases (GH16)%3B Lipoprotein-type signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane and possibly secreted in the outside medium%3B~High confidence in function and specificity gene gene4267 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4267 ZOBELLIA_4268 ZOBELLIA_4268 ZOBELLIA_4268 4983793 4985184 - Parallel beta-helix fold protein Protein probably adopting a parallel beta-helix fold and acting with polysaccharide as substrates%3B Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene4268 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4268 ZOBELLIA_4269 ZOBELLIA_4269 ZOBELLIA_4269 4985446 4986171 + Acid phosphatase/vanadium-dependent haloperoxidase family protein This enzyme belongs to the acid phosphatase/vanadium-dependent haloperoxidase family%3B Seems to have an uncleavable signal peptide%3B Possibly localized in the cytoplasmic membrane%3B~Family membership gene gene4269 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4269 ZOBELLIA_427 ZOBELLIA_427 ZOBELLIA_427 560265 560381 + Putative protein Hypothetical protein gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_427 ZOBELLIA_4270 ZOBELLIA_4270 ZOBELLIA_4270 4986325 4986687 + MarR-type transcriptional regulator The transcriptional regulators with the marR-type HTH domain control a variety of biological functions%2C including resistance to multiple antibiotics%2C household disinfectants%2C organic solvents%2C oxidative stress agents. Many of the marR-like regulators respond to aromatic compounds%3B Contains a DNA-binding%2C winged helix-turn-helix (wHTH) domain%3B Localized in the cytoplasm%3B~Family membership gene gene4270 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4270 ZOBELLIA_4271 ZOBELLIA_4271 arcB arcB 4986688 4987635 + Ornithine cyclodeaminase The Ornithine cyclodeaminase catalyses the deamination of ornithine to proline%3B The reaction uses the NAD as cofactor and is stimulated by the presence of ADP or ATP and is inhibited by O(2)%3B Belongs to the mu- crystallin protein family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4271 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4271 ZOBELLIA_4272 ZOBELLIA_4272 ZOBELLIA_4272 4987840 4989336 + Conserved hypothetical protein Lipoprotein belonging to the spore coat protein H family%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane gene gene4272 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4272 ZOBELLIA_4273 ZOBELLIA_4273 ZOBELLIA_4273 4989428 4989925 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4273 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4273 ZOBELLIA_4274 ZOBELLIA_4274 ZOBELLIA_4274 4990200 4991531 + Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B Belongs to the type I secretion system%3B~Family membership gene gene4274 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4274 ZOBELLIA_4275 ZOBELLIA_4275 macA macA 4991537 4992754 + Macrolide-specific membrane fusion protein The membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics (as macrolides)%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region%3B Belongs to the type I secretion system%3B~Family membership gene gene4275 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4275 ZOBELLIA_4276 ZOBELLIA_4276 ZOBELLIA_4276 4992764 4993507 + Macrolide-specific ABC exporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Putatively involved in the macrolides resistance%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the ABC transporter permease component%3B~Family membership gene gene4276 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4276 ZOBELLIA_4277 ZOBELLIA_4277 macB macB 4993510 4994730 + Macrolide-specific ABC exporter%2C permease component ABC (ATP-binding cassette) membrane domain possibly involved in the macrolides resistance%3B Contains four transmembrane segments%3B Belongs to the ABC transporter family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4277 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4277 ZOBELLIA_4278 ZOBELLIA_4278 ZOBELLIA_4278 4994738 4995775 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains four N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4278 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4278 ZOBELLIA_4279 ZOBELLIA_4279 ZOBELLIA_4279 4995945 4997744 + ABC-1 type exporter-Permease/ATP-binding protein The ABC-1 type transporters have their ABC membrane domain and their ABC ATPase domain fused in the same protein. They are involved in the efflux of compounds across the biological membranes or in targeting of membrane components%3B Contains five N-terminal transmembrane segments (ABC membrane) that form a pore in the cytoplasmic membrane an a C-terminal ATP-binding domain (ABC ATPase) responsible for energy generation%3B Belongs to the ABC-1 type transporter permease/ATP-binding family%2C lipid exporter subfamily (msbA)%3B~Family membership gene gene4279 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4279 ZOBELLIA_428 ZOBELLIA_428 ZOBELLIA_428 560448 560540 + Putative protein Hypothetical protein gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_428 ZOBELLIA_4280 ZOBELLIA_4280 ZOBELLIA_4280 4997794 4999116 + Conserved hypothetical membrane protein Contains two transmembrane segments in the N-terminal part of protein%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4280 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4280 ZOBELLIA_4281 ZOBELLIA_4281 ZOBELLIA_4281 4999113 4999712 + Phosphatidylethanolamine-binding protein Protein possibly involved in the Phospholipid binding%3B Belongs to the phosphatidylethanolamine-binding protein (PEBP) family%3B Lipoprotein-type signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Function unclear gene gene4281 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4281 ZOBELLIA_4282 ZOBELLIA_4282 ZOBELLIA_4282 4999730 5000737 + Conserved hypothetical membrane protein Putative lipoprotein signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene4282 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4282 ZOBELLIA_4283 ZOBELLIA_4283 ZOBELLIA_4283 5000774 5001508 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene4283 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4283 ZOBELLIA_4284 ZOBELLIA_4284 ZOBELLIA_4284 5001651 5002100 + Possible co-chaperone Hypothetical Co-chaperone that could be part of a chaperone (protein folding) system%3B Contains a N-terminal 'J' domain%3B Belongs to the J-protein family%2C type 3 subgroup%3B Localized in the cytoplasm%3B~Function unclear gene gene4284 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4284 ZOBELLIA_4285 ZOBELLIA_4285 ZOBELLIA_4285 5002226 5003557 + DEAD/DEAH RNA helicase Protein that could be involved in ATP-dependent RNA unwinding in a variety of cellular processes%2C including ribosome assembly%2C protein synthesis%2C and RNA degradation%3B Contains a DEAD box%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%2C DEAD box subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene4285 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4285 ZOBELLIA_4286 ZOBELLIA_4286 dbpA dbpA 5003561 5004874 + RNA helicase DbpA RNA helicase DbpA Has a helix-destabilizing activity%2C not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity%2C specifically stimulated by bacterial 23S rRNA. Could play a major role in the assembly process of the active center of 50S ribosomal subunits%3B Contains a C-terminal DbpA RNA binding domain specific for hairpin 92 of 23S rRNA%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%2C DEAD box subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4286 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4286 ZOBELLIA_4287 ZOBELLIA_4287 cspA5 cspA5 5005272 5005463 + Cold shock protein Cold shock proteins (CSPs) help the cell to survive in temperatures lower than optimum growth temperature. CSPs may act as RNA chaperones by destabilizing RNA secondary structures%2C regulating ribosomal translation%2C rate of mRNA degradation and termination of transcription%3B Contains a 'cold-shock domain' (CSD) involved in the single-strand nucleic-acid binding%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4287 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4287 ZOBELLIA_4288 ZOBELLIA_4288 ZOBELLIA_4288 5005766 5006065 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B localized in the outer membrane%3B~Hypothetical protein gene gene4288 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4288 ZOBELLIA_4289 ZOBELLIA_4289 ZOBELLIA_4289 5006305 5006892 + Conserved hypothetical membrane protein Protein that corresponds to a conserved domain in several bacterial protein%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4289 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4289 ZOBELLIA_429 ZOBELLIA_429 ZOBELLIA_429 560528 561520 + Conserved hypothetical protein Contains two transmembrane segments%3B Probably localized in the cytoplasmic membrane gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_429 ZOBELLIA_4290 ZOBELLIA_4290 ZOBELLIA_4290 5007143 5008690 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene4290 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4290 ZOBELLIA_4291 ZOBELLIA_4291 ZOBELLIA_4291 5008706 5009317 - DEAD/DEAH RNA helicase Protein that could be involved in ATP-dependent RNA unwinding in a variety of cellular processes%2C including ribosome assembly%2C protein synthesis%2C and RNA degradation%3B Contains a DEAD box%3B Belongs to the helicases superfamily II%2C DEAD/DEAH box RNA helicase family%3B Localized in the cytoplasm%3B~Family membership gene gene4291 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4291 ZOBELLIA_4292 ZOBELLIA_4292 ZOBELLIA_4292 5009735 5011384 + Serine peptidase%2C family S12 Serine peptidase belonging to the family S12%2C which includes D-Ala-D-Ala carboxypeptidase B and aminopeptidase DmpB. The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa-Thr-Lys. Signal peptide cleaved between the residues 22 and 23. Localized in the periplasmic space.%3B~Specificity unclear gene gene4292 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4292 ZOBELLIA_4293 ZOBELLIA_4293 ZOBELLIA_4293 5011543 5012523 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4293 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4293 ZOBELLIA_4294 ZOBELLIA_4294 ZOBELLIA_4294 5012550 5012921 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4294 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4294 ZOBELLIA_4295 ZOBELLIA_4295 ZOBELLIA_4295 5013376 5014305 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4295 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4295 ZOBELLIA_4296 ZOBELLIA_4296 ZOBELLIA_4296 5014518 5014613 - Putative protein Hypothetical protein gene gene4296 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4296 ZOBELLIA_4297 ZOBELLIA_4297 ZOBELLIA_4297 5014632 5016368 + Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4297 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4297 ZOBELLIA_4298 ZOBELLIA_4298 ZOBELLIA_4298 5016379 5016744 + Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4298 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4298 ZOBELLIA_4299 ZOBELLIA_4299 ZOBELLIA_4299 5016765 5017664 - DUF6 family protein Conserved membrane protein containing two DUF family domains. Features ten transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene4299 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4299 ZOBELLIA_43 ZOBELLIA_43 trmH trmH 43982 44638 - tRNA guanosine-2'-O-methyltransferase The tRNA guanosine-2'-O-methyltransferase methylates the 2'-hydroxy group of a guanosine present in a GG sequence at position 18 of tRNAs using the S-adenosyl methionine cofactor%3B Contains a catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_43 ZOBELLIA_430 ZOBELLIA_430 ZOBELLIA_430 561659 561793 + Putative protein Hypothetical protein gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_430 ZOBELLIA_4300 ZOBELLIA_4300 ZOBELLIA_4300 5017879 5019099 + Patatin-like phospholipase Conserved phospholipase belonging to the patatin family. Displays a C-terminal domain of unknown function.%3B~Family membership gene gene4300 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4300 ZOBELLIA_4301 ZOBELLIA_4301 ZOBELLIA_4301 5019141 5020334 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4301 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4301 ZOBELLIA_4302 ZOBELLIA_4302 ZOBELLIA_4302 5020327 5022111 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4302 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4302 ZOBELLIA_4303 ZOBELLIA_4303 ZOBELLIA_4303 5022282 5023550 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4303 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4303 ZOBELLIA_4304 ZOBELLIA_4304 ZOBELLIA_4304 5024215 5024418 + Putative protein Hypothetical protein gene gene4305 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4304 ZOBELLIA_4305 ZOBELLIA_4305 iyd iyd 5023558 5024250 - Iodotyrosine dehalogenase Iodotyrosine dehalogenase catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Uses FMN and NADPH as cofactors. Belongs to the nitroreductase family. Localized in the cytoplasm.%3B~Hypothetical protein gene gene4304 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4305 ZOBELLIA_4306 ZOBELLIA_4306 ZOBELLIA_4306 5024407 5025039 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4306 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4306 ZOBELLIA_4307 ZOBELLIA_4307 ZOBELLIA_4307 5025060 5025653 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B localized in the outer membrane%3B~Conserved hypothetical protein gene gene4307 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4307 ZOBELLIA_4308 ZOBELLIA_4308 ZOBELLIA_4308 5026013 5026321 + Putative protein Hypothetical protein gene gene4308 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4308 ZOBELLIA_4309 ZOBELLIA_4309 ZOBELLIA_4309 5026332 5026592 + Putative protein Hypothetical protein gene gene4309 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4309 ZOBELLIA_431 ZOBELLIA_431 ZOBELLIA_431 561787 562662 + Hypothetical protein Contains two transmembrane segments%3B Pobably localized in the cytoplasmic membrane gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_431 ZOBELLIA_4310 ZOBELLIA_4310 ZOBELLIA_4310 5026881 5028362 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4310 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4310 ZOBELLIA_4311 ZOBELLIA_4311 norBC norBC 5028468 5030696 - Nitric oxide reductase Nitric oxide reductase (NOR) is a component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification). NorBC is a modular protein consisting of a N-terminal domain distantly related to NorC and a C-terminal domain Binds a heme as cofactor%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4311 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4311 ZOBELLIA_4312 ZOBELLIA_4312 ZOBELLIA_4312 5030707 5031048 - Conserved hypothetical protein Protein displaying the conserved barrel domain of the 'cupin' superfamily%3B Localized in the cytoplasm gene gene4312 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4312 ZOBELLIA_4313 ZOBELLIA_4313 ZOBELLIA_4313 5031686 5032246 + Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4313 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4313 ZOBELLIA_4314 ZOBELLIA_4314 ZOBELLIA_4314 5032227 5032328 - Putative protein Hypothetical protein gene gene4314 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4314 ZOBELLIA_4315 ZOBELLIA_4315 ZOBELLIA_4315 5032370 5032468 + Putative protein Hypothetical protein gene gene4315 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4315 ZOBELLIA_4316 ZOBELLIA_4316 ZOBELLIA_4316 5032455 5034011 + Conserved hypothetical membrane protein Displays distant similarity with the Patatin-like phospholipases%3B Contains two central transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4316 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4316 ZOBELLIA_4317 ZOBELLIA_4317 ZOBELLIA_4317 5034008 5034541 + Hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4317 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4317 ZOBELLIA_4318 ZOBELLIA_4318 ZOBELLIA_4318 5034613 5035173 - Conserved hypothetical protein Localized in the cytoplasm gene gene4318 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4318 ZOBELLIA_4319 ZOBELLIA_4319 ZOBELLIA_4319 5035427 5036290 - Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4319 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4319 ZOBELLIA_432 ZOBELLIA_432 ZOBELLIA_432 562671 563546 + Hypothetical protein Contains two transmenbrane segments%3B Probably localized in the cytoplasmic membrane gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_432 ZOBELLIA_4320 ZOBELLIA_4320 ZOBELLIA_4320 5036373 5036561 + Putative protein Hypothetical protein gene gene4320 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4320 ZOBELLIA_4321 ZOBELLIA_4321 ZOBELLIA_4321 5036603 5037904 - Na+/H+ antiporter Protein that could be involved in pH homeostasis and sodium extrusion%3B Belongs to the nhaC Na(+)/H(+) antiporter family%3B Contains eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4321 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4321 ZOBELLIA_4322 ZOBELLIA_4322 ZOBELLIA_4322 5037937 5038182 + Putative protein Hypothetical protein gene gene4322 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4322 ZOBELLIA_4323 ZOBELLIA_4323 ZOBELLIA_4323 5038371 5038511 - Putative protein Hypothetical protein gene gene4323 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4323 ZOBELLIA_4324 ZOBELLIA_4324 ZOBELLIA_4324 5038562 5040148 + Conserved hypothetical periplasmic protein This protein displays three KWG repeats (residues 175-189%2C 258-275 and 307-323)%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4324 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4324 ZOBELLIA_4325 ZOBELLIA_4325 ZOBELLIA_4325 5040338 5041360 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B localized in the outer membrane%3B~Hypothetical protein gene gene4325 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4325 ZOBELLIA_4326 ZOBELLIA_4326 ZOBELLIA_4326 5041738 5043846 + Beta-helix fold protein Conserved protein adopting a parallel beta-helix fold. Features a signal peptide cleaved between the residues 27 and 28. Localized in the periplasm.%3B~Conserved hypothetical protein gene gene4326 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4326 ZOBELLIA_4327 ZOBELLIA_4327 alyA7 alyA7 5043878 5045050 + Alginate lyase%2C family PL14 Alginate lyase catalyzes the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. It belongs to the family 7 of the polysaccharide lyases. Display also a C-terminal conserved domain of unknown function. Features an uncleaved signal peptide.%2C Features a signal peptide cleaved between residues 24 and 25. Localized in the periplasm.%3B~High confidence in function and specificity gene gene4327 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4327 ZOBELLIA_4328 ZOBELLIA_4328 ZOBELLIA_4328 5045140 5046480 - ABC-2 type exporter%2C permease component Putatif ABC-2 type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4328 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4328 ZOBELLIA_4329 ZOBELLIA_4329 ZOBELLIA_4329 5046481 5047920 - ABC-2 type exporter%2C permease component Putatif ABC-2 type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4329 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4329 ZOBELLIA_433 ZOBELLIA_433 ZOBELLIA_433 563555 563752 + Pseudogene Possible pseudogene%3B~Hypothetical protein pseudogene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_433 ZOBELLIA_4330 ZOBELLIA_4330 ZOBELLIA_4330 5047923 5050430 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (21-101) and the Plug module (136-233) acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Family membership gene gene4330 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4330 ZOBELLIA_4331 ZOBELLIA_4331 ZOBELLIA_4331 5050436 5051206 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene4331 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4331 ZOBELLIA_4332 ZOBELLIA_4332 ZOBELLIA_4332 5051388 5051687 - hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4332 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4332 ZOBELLIA_4333 ZOBELLIA_4333 ZOBELLIA_4333 5051998 5052738 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4333 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4333 ZOBELLIA_4334 ZOBELLIA_4334 ZOBELLIA_4334 5052974 5053096 - Putative protein Hypothetical protein gene gene4334 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4334 ZOBELLIA_4335 ZOBELLIA_4335 ZOBELLIA_4335 5053139 5055229 - AraC-type transcriptional regulator Modular protein containing two N-terminal AraC-type HTH DNA-binding domains involved in the binding of the protein to the operator sequences in the DNA followed by two C-terminal Tetratricopeptide repeats. AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons. TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes. A single TPR contains two antiparallel alpha helices which pack into an open structure such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that might accommodate the complementary region of a target protein. Localized in the cytoplasm.%3B~Function unclear gene gene4335 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4335 ZOBELLIA_4336 ZOBELLIA_4336 ZOBELLIA_4336 5055450 5056037 + Ankyrin repeats protein Conserved protein containing three ankyrin repeats%2C one of the most common protein-protein interaction motifs in nature%3B Signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Function unclear gene gene4336 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4336 ZOBELLIA_4337 ZOBELLIA_4337 ZOBELLIA_4337 5056065 5057165 + Acyltransferase family protein Conserved protein belonging to the acyltransferase family. Its exact function is unclear. Features ten transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene4337 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4337 ZOBELLIA_4338 ZOBELLIA_4338 ZOBELLIA_4338 5057308 5057886 + Dual specificity protein phosphatase Protein phosphatase with activity toward tyrosine-protein phosphate as well as toward serine-protein phosphate. Features a signal peptide cleaved between the residues 23 and 24. Localized in the periplasm.%3B~Specificity unclear gene gene4338 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4338 ZOBELLIA_4339 ZOBELLIA_4339 ZOBELLIA_4339 5058014 5059012 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4339 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4339 ZOBELLIA_434 ZOBELLIA_434 ZOBELLIA_434 563996 564358 + Hypothetical protein Localized in the cytoplasm gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_434 ZOBELLIA_4340 ZOBELLIA_4340 ZOBELLIA_4340 5059117 5059884 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4340 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4340 ZOBELLIA_4341 ZOBELLIA_4341 ybhR ybhR 5059903 5061024 - ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene4341 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4341 ZOBELLIA_4342 ZOBELLIA_4342 ybhS ybhS 5061024 5062130 - ABC-2 type exporter%2C permease component ABC-2 Type (ATP-binding cassette) transporter%2C membrane domain%3B ABC-2 type transporters are responsible for extrusion of a variety of compounds across biological membranes%3B Contains six transmembrane segments%3B The proteins form homo- or hetero-oligomeric channels%2C allowing ATP-mediated transport%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene4342 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4342 ZOBELLIA_4343 ZOBELLIA_4343 ybhF1 ybhF1 5062127 5062855 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene4343 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4343 ZOBELLIA_4344 ZOBELLIA_4344 ybhF2 ybhF2 5062852 5063754 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component%3B~Family membership gene gene4344 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4344 ZOBELLIA_4345 ZOBELLIA_4345 ybhG ybhG 5063751 5064647 - Membrane fusion protein The membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics%2C solvents or heavy metals%3B Proteins of the MFP family function as 'adaptors'%2C connecting a ABC transporters%2C localized in the cytoplasmic membrane%2C with a porin or channel localized in outer membrane%3B The MFP proteins seem to be anchored in the cytoplasmic membrane by a N-terminal transmembrane region%3B Lipoprotein with a signal peptide cleaved between the residues 19 and 20%3B Belongs to the type I secretion system%3B~Specificity unclear gene gene4345 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4345 ZOBELLIA_4346 ZOBELLIA_4346 ZOBELLIA_4346 5064659 5065906 - Outer membrane efflux protein The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous%2C solvent-accessible conduit that spans both the outer membrane and periplasmic space%3B May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system)%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Family membership gene gene4346 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4346 ZOBELLIA_4347 ZOBELLIA_4347 ZOBELLIA_4347 5065908 5066522 - TetR-type transcriptional regulator Contains 1 HTH tetR-type DNA-binding domain (1 to 42) with an helix-turn-helix (HTH) motif (5 to 24)%3B This domain is present in the N-terminal extremity of the tetR family of prokaryotic transcription regulators. The C-terminal part of these regulators contains several regions that can be involved in binding of inducers%2C which can be antibiotics%2C antiseptics%2C disinfectants or host-encoded antimicrobials%3B~Family membership gene gene4347 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4347 ZOBELLIA_4348 ZOBELLIA_4348 ZOBELLIA_4348 5066825 5067751 + Conserved hypothetical protein Localized in the cytoplasm gene gene4348 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4348 ZOBELLIA_4349 ZOBELLIA_4349 ZOBELLIA_4349 5067810 5068505 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4349 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4349 ZOBELLIA_435 ZOBELLIA_435 ZOBELLIA_435 564362 564508 + Putative protein Hypothetical protein gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_435 ZOBELLIA_4350 ZOBELLIA_4350 ZOBELLIA_4350 5068664 5069938 + Conserved hypothetical protein Localized in the cytoplasm gene gene4350 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4350 ZOBELLIA_4351 ZOBELLIA_4351 ZOBELLIA_4351 5070008 5070172 + Putative protein Hypothetical protein gene gene4351 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4351 ZOBELLIA_4352 ZOBELLIA_4352 ZOBELLIA_4352 5070889 5071506 - Hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Hypothetical protein gene gene4352 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4352 ZOBELLIA_4353 ZOBELLIA_4353 ZOBELLIA_4353 5071503 5072606 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases (GT4)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4353 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4353 ZOBELLIA_4354 ZOBELLIA_4354 ZOBELLIA_4354 5072606 5073013 - Hypothetical protein Putatively localized in the cytoplasm gene gene4354 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4354 ZOBELLIA_4355 ZOBELLIA_4355 ZOBELLIA_4355 5073019 5073972 - Hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4355 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4355 ZOBELLIA_4356 ZOBELLIA_4356 ZOBELLIA_4356 5073974 5075128 - Glycosyltransferase%2C family GT4 Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases (GT4)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4356 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4356 ZOBELLIA_4357 ZOBELLIA_4357 ZOBELLIA_4357 5075131 5075685 - LemA family protein The exact molecular function of this protein is unknown%3B Belongs to the LemA family%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4357 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4357 ZOBELLIA_4358 ZOBELLIA_4358 ZOBELLIA_4358 5075927 5076526 + Conserved hypothetical protein Localized in the cytoplasm gene gene4358 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4358 ZOBELLIA_4359 ZOBELLIA_4359 ZOBELLIA_4359 5076549 5076779 + Putative protein Hypothetical protein gene gene4359 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4359 ZOBELLIA_436 ZOBELLIA_436 ZOBELLIA_436 564512 565438 + Conserved hypothetical protein Localized in the cytoplasm. gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_436 ZOBELLIA_4360 ZOBELLIA_4360 ZOBELLIA_4360 5076760 5077200 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4360 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4360 ZOBELLIA_4361 ZOBELLIA_4361 ZOBELLIA_4361 5077798 5078685 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane)%3B~Family membership gene gene4361 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4361 ZOBELLIA_4362 ZOBELLIA_4362 ZOBELLIA_4362 5078718 5082362 + Aminopeptidase%2C family M1 Integral membrane protein with a C-terminal aminopeptidase domain. Belongs to the family M1 of the peptidase. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Features 13 transmembrane helices.%3B~Specificity unclear gene gene4362 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4362 ZOBELLIA_4363 ZOBELLIA_4363 sqrA sqrA 5082578 5084008 - Sulfide:quinone oxidoreductase Enzyme that uses electrons from H2S to reduce quinones with the use of NADP. S0 is oxidized to sulfite and water. This process confers resistance to heavy metals such as cadmium and cisplatin%3B Binds 1 FAD noncovalently as cofactors%3B Belongs to the Pyridine nucleotide- disulphide oxidoreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4363 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4363 ZOBELLIA_4364 ZOBELLIA_4364 ZOBELLIA_4364 5084185 5084694 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4364 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4364 ZOBELLIA_4365 ZOBELLIA_4365 ZOBELLIA_4365 5084994 5085131 + Putative protein Hypothetical protein gene gene4365 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4365 ZOBELLIA_4366 ZOBELLIA_4366 ZOBELLIA_4366 5085332 5085445 + Putative protein Hypothetical protein gene gene4366 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4366 ZOBELLIA_4367 ZOBELLIA_4367 ZOBELLIA_4367 5085469 5085855 - Fur-type transcriptional regulator Transcriptional regulator belonging to the Ferric uptake regulator or FUR family%2C which includes metal ion uptake regulator proteins%2C which bind to the operator DNA and control the transcription of metal ion-responsive genes. Localized in the cytoplasm.%3B~Family membership gene gene4367 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4367 ZOBELLIA_4368 ZOBELLIA_4368 ZOBELLIA_4368 5085935 5086339 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4368 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4368 ZOBELLIA_4369 ZOBELLIA_4369 folE3 folE3 5086329 5086994 + GTP cyclohydrolase I GTP cyclohydrolase I catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate. FolE is a homodecamer%2C composed of a dimer of pentamers. It is an allosteric enzyme%2C whose activity is modulated by K(+)%2C divalent cations%2C UTP%2C and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4369 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4369 ZOBELLIA_437 ZOBELLIA_437 ZOBELLIA_437 565711 566451 + Conserved hypothetical protein Localized in the cytoplasm. gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_437 ZOBELLIA_4370 ZOBELLIA_4370 ZOBELLIA_4370 5087053 5087958 + CobW-like nucleotide binding protein Conserved protein belonging to the CobW nucleotide binding domain family. Localized in the cytoplasm.%3B~Function unclear gene gene4370 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4370 ZOBELLIA_4371 ZOBELLIA_4371 phoA phoA 5088223 5089632 - Alkaline phosphatase Alkaline phosphatase is a zinc and magnesium-containing metalloenzyme which hydrolyzes phosphate esters%2C optimally at high pH%3B Alkaline phosphatase exists as a dimer%2C each monomer binding 2 zinc atoms and one magnesium atom%2C which are essential for enzymic activity%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene4371 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4371 ZOBELLIA_4372 ZOBELLIA_4372 ZOBELLIA_4372 5089663 5090100 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4372 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4372 ZOBELLIA_4373 ZOBELLIA_4373 ZOBELLIA_4373 5090090 5091331 - ABC transporter%2C permease component ABC (ATP-binding cassette) transporters are responsible for translocation of a variety of compounds across biological membranes%3B Contains four transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4373 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4373 ZOBELLIA_4374 ZOBELLIA_4374 ZOBELLIA_4374 5091328 5091957 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with the ABC transporter permease component%3B~Family membership gene gene4374 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4374 ZOBELLIA_4375 ZOBELLIA_4375 ZOBELLIA_4375 5091983 5093179 - P47K The presence of P47K%2C also known as 47 kDa protein in Pseudomonas chlororaphis B23%2C is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins. Features a N-terminal cobW-like nucleotide-binding domain and a cobW-like C-terminal domain. Localized in the cytoplasm.%3B~Function unclear gene gene4375 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4375 ZOBELLIA_4376 ZOBELLIA_4376 ZOBELLIA_4376 5093698 5094006 - Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4376 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4376 ZOBELLIA_4377 ZOBELLIA_4377 ZOBELLIA_4377 5094230 5094619 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B localized in the outer membrane%3B~Hypothetical protein gene gene4377 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4377 ZOBELLIA_4378 ZOBELLIA_4378 ZOBELLIA_4378 5095894 5096232 - Putative protein Hypothetical protein gene gene4378 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4378 ZOBELLIA_4379 ZOBELLIA_4379 ZOBELLIA_4379 5096679 5096996 - Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4379 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4379 ZOBELLIA_438 ZOBELLIA_438 ZOBELLIA_438 566551 567105 + Conserved hypothetical protein Localized in the cytoplasm gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_438 ZOBELLIA_4380 ZOBELLIA_4380 ZOBELLIA_4380 5097146 5097655 + Conserved hypothetical periplasmic protein Protein that could play an role in isoprenoid quinone metabolism and/or transport and/or storage%3B Belongs to the YceI family%3B Signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Function unclear gene gene4380 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4380 ZOBELLIA_4381 ZOBELLIA_4381 alx alx 5097774 5098730 + Inner membrane protein alx Alx is a protein that could be induced by extreme alkaline conditions. The exact function of Alx is unknown. A number of conserved aspartates may be involved in metal ion binding%3B Belongs to the TerC family%3B Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4381 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4381 ZOBELLIA_4382 ZOBELLIA_4382 ZOBELLIA_4382 5098773 5099243 - Hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4382 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4382 ZOBELLIA_4383 ZOBELLIA_4383 acpP4 acpP4 5099203 5099457 - Acyl carrier protein Acyl carrier protein (ACP) is the carrier of the growing fatty acid chain in fatty acid biosynthesis. ACP is produced as an apoprotein and is converted to its active form by [ACP]synthase (AcpS)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4383 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4383 ZOBELLIA_4384 ZOBELLIA_4384 fabB7 fabB7 5099494 5100768 - 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] synthase%2C also known as beta-ketoacyl synthase%2C catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids%3B Belongs to the Beta-ketoacyl synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4384 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4384 ZOBELLIA_4385 ZOBELLIA_4385 fabZ3 fabZ3 5100761 5101201 - (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (3R)-Hydroxymyristoyl-[acyl-carrier-protein] dehydratase (FabZ) catalyses the dehydratation of beta-hydroxyacyl-ACP generated by FabG to trans-2-enoyl-ACP. This is the third step of the fatty acid elongation cycle. FabZ forms a hexamer (a trimer of dimers)and the monomer adopts a beta + alpha \\hotdog\\ fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4385 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4385 ZOBELLIA_4386 ZOBELLIA_4386 ZOBELLIA_4386 5101255 5102031 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene4386 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4386 ZOBELLIA_4387 ZOBELLIA_4387 ZOBELLIA_4387 5102065 5103120 - Type III polyketide synthase Type III polyketide synthases are homodimeric enzymes that iteratively carry out the polyketide synthesis at one single active site%3B Belongs to the chalcone/stilbene synthase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4387 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4387 ZOBELLIA_4388 ZOBELLIA_4388 ZOBELLIA_4388 5103137 5103841 - Conserved hypothetical protein Localized in the cytoplasm gene gene4388 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4388 ZOBELLIA_4389 ZOBELLIA_4389 ZOBELLIA_4389 5103842 5104963 - Aromatic-ring hydroxylase%2C FAD-dependent oxidoreductase family Aromatic-ring hydroxylases (or monooxygenases) catalyze the incorporation of one atom of dioxygen into an aromatic compound and the reduction of the other oxygen atom to water. These oxidoreductases are FAD-dependent and adopt a Rossmann fold%3B Belongs to the pyridine nucleotide-disulphide reductases superfamily%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4389 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4389 ZOBELLIA_439 ZOBELLIA_439 ZOBELLIA_439 567172 568002 + Conserved hypothetical protein Localized in the cytoplasm. gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_439 ZOBELLIA_4390 ZOBELLIA_4390 ZOBELLIA_4390 5105054 5105749 - OmpA-like membrane protein Modular protein that contains a N-terminal Rickettsia 17 kDa surface antigen-like domain and a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene4390 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4390 ZOBELLIA_4391 ZOBELLIA_4391 ZOBELLIA_4391 5105760 5106242 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B localized in the outer membrane%3B~Conserved hypothetical protein gene gene4391 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4391 ZOBELLIA_4392 ZOBELLIA_4392 bkdA1 bkdA1 5106383 5108359 - 2-Oxoisovalerate dehydrogenase%2C E1 component The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine%2C leucine and isoleucine biodegradation. This complex contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 component displays a modular architecture. The N-terminal domain is a dehydrogenase and the C-terminal domain belongs to the transketolase family. Both activities uses thiamine pyrophosphate as prosthetic group%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4392 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4392 ZOBELLIA_4393 ZOBELLIA_4393 ZOBELLIA_4393 5108489 5109439 + Dioxygenase Conserved dioxygenase of unknown specificity. Belongs to the 2OG-Fe(II) oxygenase superfamily%2C which includes various enzymes such as Leucoanthocyanidin dioxygenase%2C flavanone 3-hydroxylase and Gibberellin 20 oxidase. Localized in the cytoplasm.%3B~Specificity unclear gene gene4393 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4393 ZOBELLIA_4394 ZOBELLIA_4394 yciH yciH 5109442 5109771 + Protein translation factor SUI1 homolog Protein Belongs to the SUI1 family%3B Localized in the cytoplasm%3B~Family membership gene gene4394 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4394 ZOBELLIA_4395 ZOBELLIA_4395 ZOBELLIA_4395 5109890 5110822 + Conserved hypothetical protein Localized in the cytoplasm gene gene4395 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4395 ZOBELLIA_4396 ZOBELLIA_4396 udpA udpA 5110827 5111699 + Uridine phosphorylase Uridine phosphorylase catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis%3B Forms a homohexamer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4396 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4396 ZOBELLIA_4397 ZOBELLIA_4397 ZOBELLIA_4397 5111825 5112682 + Conserved hypothetical protein Localized in the cytoplasm gene gene4397 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4397 ZOBELLIA_4398 ZOBELLIA_4398 ZOBELLIA_4398 5112757 5113188 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4398 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4398 ZOBELLIA_4399 ZOBELLIA_4399 ungA ungA 5113178 5113843 - Uracil-DNA glycosylase Uracil-DNA glycosylase excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase to form U:A pairs or due to deamination of cytosine to form mutagenic U:G mispairs. These aberrant uracil residues are genotoxic%3B Belongs to the uracil-DNA glycosylase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4399 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4399 ZOBELLIA_44 ZOBELLIA_44 npdA npdA 44674 45366 + NAD-dependent protein deacetylase NAD-dependent deacetylase activates the enzyme acetyl-CoA synthetase by deacetylating its catalytic Lysine in the inactive%2C acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes. It binds one zinc ion as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_44 ZOBELLIA_440 ZOBELLIA_440 ZOBELLIA_440 568018 568536 + Hypothetical protein Localized in the cytoplasm gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_440 ZOBELLIA_4400 ZOBELLIA_4400 ZOBELLIA_4400 5113983 5114492 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B localized in the outer membrane%3B~Conserved hypothetical protein gene gene4400 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4400 ZOBELLIA_4401 ZOBELLIA_4401 mutS2 mutS2 5114571 5116745 + DNA mismatch repair protein MutS The MutS protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity%3B Contains a central MutS_V domain%3B Belongs to the MutS family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene4401 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4401 ZOBELLIA_4402 ZOBELLIA_4402 ZOBELLIA_4402 5116853 5117260 + Conserved hypothetical protein Conserved protein belonging to the DUF393 family. Proteins in this family are predicted to have a thioredoxin-like fold which%2C together with the presence of an invariant catalytic cysteine residue%2C suggesting that they are a novel group of thiol-disulphide oxidoreductases. Localized in the cytoplasm. gene gene4402 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4402 ZOBELLIA_4403 ZOBELLIA_4403 gltT gltT 5117306 5118592 - Proton/sodium-glutamate symporter Carrier protein which is part of the Na(+)-dependent%2C binding-protein-independent glutamate-aspartate transport system. GltT participates in nutrient uptake%3B Forms a homotrimer%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4403 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4403 ZOBELLIA_4404 ZOBELLIA_4404 aroC aroC 5118730 5119800 - Chorismate synthase Chorismate synthase is involved in the last of the seven steps in the shikimate pathway which is used for the biosynthesis of aromatic amino acids. It catalyzes the 1%2C 4- trans elimination of the phosphate group from 5-enolpyruvylshikimate-3-phosphate to form chorismate which can then be used in phenylalanine%2C tyrosine or tryptophan biosynthesis. Uses the reduced flavin mononucleotide (FMNH2 or FADH2) as prosthetic group%3B Forms a homotetramer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4404 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4404 ZOBELLIA_4405 ZOBELLIA_4405 ZOBELLIA_4405 5120155 5121015 + Metallophosphoesterase Conserved protein belonging to the metallophosphoesterase family. The most conserved regions in this family centre around the metal chelating residues%3B Localized in the cytoplasm%3B~Family membership gene gene4405 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4405 ZOBELLIA_4406 ZOBELLIA_4406 ZOBELLIA_4406 5121021 5123930 - FAD-dependent oxidoreductase Conserved protein containing a N-terminal FAD-dependent oxidoreductase domain and a C-terminal domain containing a 4Fe-4S cluster. These domains are distantly related to the D-lactate dehydrogenase and the subunit C of the glycerol-3-phosphate dehydrogenase%2C respectively. The function of this modular protein is unknown.%3B~Function unclear gene gene4406 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4406 ZOBELLIA_4407 ZOBELLIA_4407 ZOBELLIA_4407 5124018 5124536 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4407 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4407 ZOBELLIA_4408 ZOBELLIA_4408 ZOBELLIA_4408 5124637 5125755 + Thiol-disulfide oxidoreductase Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Belongs to the thioredoxin family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B localized in the outer membrane%3B~High confidence in function and specificity gene gene4408 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4408 ZOBELLIA_4409 ZOBELLIA_4409 ZOBELLIA_4409 5125832 5127472 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B localized in the outer membrane%3B~Conserved hypothetical protein gene gene4409 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4409 ZOBELLIA_441 ZOBELLIA_441 ZOBELLIA_441 568548 569042 + Hypothetical protein Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_441 ZOBELLIA_4410 ZOBELLIA_4410 ZOBELLIA_4410 5127652 5128302 - Serine endopeptidase%2C family S54 Serine endopeptidase belonging to the family S54. This family includes the protein Rhomboid which is a peptidase important for embryo development in Drosophila melanogaster. The active site is a catalytic diad Ser%2C His. Features seven transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene4410 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4410 ZOBELLIA_4411 ZOBELLIA_4411 htrB htrB 5128359 5129246 + Lipid A biosynthesis lauroyl acyltransferase Lipid A biosynthesis lauroyl acyltransferase is involved in lipopolysaccharide biosynthesis. It transfers myristate or laurate%2C activated on ACP%2C to the lipid A moiety of (KDO)2-(lauroyl)-lipid IVA during lipopolysaccharide core biosynthesis. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4411 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4411 ZOBELLIA_4412 ZOBELLIA_4412 algC algC 5129420 5130808 - Phosphomannomutase/phosphoglucomutase AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4412 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4412 ZOBELLIA_4413 ZOBELLIA_4413 acpH acpH 5130884 5131468 + Acyl carrier protein phosphodiesterase Acyl carrier protein phosphodiesterase is involved in fatty acid biosynthesis. It converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4413 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4413 ZOBELLIA_4414 ZOBELLIA_4414 ggtA ggtA 5131530 5133233 + Gamma-glutamyltranspeptidase%2C family T3 Gamma-glutamyltranspeptidase is a threonine peptidase that catalyzes the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid%2C a peptide or water (forming glutamate). GgtA plays a key role in the gamma-glutamyl cycle%2C a pathway for the synthesis and degradation of glutathione. This enzyme consists of two polypeptide chains%2C a heavy and a light subunit%2C processed from a single chain precursor%3B Belongs to the family T3 of the peptidases%3B Putative lipoprotein signal peptide cleaved between the residues 19 and 20%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene4414 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4414 ZOBELLIA_4415 ZOBELLIA_4415 ZOBELLIA_4415 5133244 5133960 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4415 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4415 ZOBELLIA_4416 ZOBELLIA_4416 ZOBELLIA_4416 5133987 5134163 - Conserved hypothetical protein Localized in the cytoplasm gene gene4416 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4416 ZOBELLIA_4417 ZOBELLIA_4417 ZOBELLIA_4417 5134303 5135043 + Conserved hypothetical protein Localized in the cytoplasm gene gene4417 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4417 ZOBELLIA_4418 ZOBELLIA_4418 ZOBELLIA_4418 5135118 5135723 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 33 and 34%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4418 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4418 ZOBELLIA_4419 ZOBELLIA_4419 ZOBELLIA_4419 5135842 5136975 - Metallo-beta-lactamase superfamily protein Protein belonging to the zinc-dependent beta-lactamase superfamily. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene4419 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4419 ZOBELLIA_442 ZOBELLIA_442 ZOBELLIA_442 569108 569722 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_442 ZOBELLIA_4420 ZOBELLIA_4420 ZOBELLIA_4420 5136980 5137798 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene4420 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4420 ZOBELLIA_4421 ZOBELLIA_4421 ZOBELLIA_4421 5138003 5138647 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4421 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4421 ZOBELLIA_4422 ZOBELLIA_4422 ZOBELLIA_4422 5138716 5138973 - Conserved hypothetical protein Localized in the cytoplasm gene gene4422 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4422 ZOBELLIA_4423 ZOBELLIA_4423 ZOBELLIA_4423 5139153 5139617 - Conserved hypothetical protein Localized in the cytoplasm gene gene4423 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4423 ZOBELLIA_4424 ZOBELLIA_4424 ZOBELLIA_4424 5140253 5140876 - Conserved hypothetical protein Localized in the cytoplasm gene gene4424 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4424 ZOBELLIA_4425 ZOBELLIA_4425 ZOBELLIA_4425 5141136 5141906 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4425 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4425 ZOBELLIA_4426 ZOBELLIA_4426 ZOBELLIA_4426 5142060 5142398 - Conserved hypothetical protein Localized in the cytoplasm gene gene4426 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4426 ZOBELLIA_4427 ZOBELLIA_4427 dpsA4 dpsA4 5142410 5142889 - DNA protection during starvation protein Dsp protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions%2C which prevents hydroxyl radical production by the Fenton reaction%3B Forms a homododecamer and the 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4427 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4427 ZOBELLIA_4428 ZOBELLIA_4428 ZOBELLIA_4428 5142895 5144238 - Metallo-beta-lactamase superfamily protein Protein with a N-terminal domain belonging to the metallo-beta-lactamase superfamily and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue. The active site of the metallo-beta-lactamase domain is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions%3B Localized in the cytoplasm%3B~Function unclear gene gene4428 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4428 ZOBELLIA_4429 ZOBELLIA_4429 ZOBELLIA_4429 5144330 5144605 + Pseudogene of protein This protein corresponds to a central fragment of an hypothetical protein from Kordia algicida and is likely an inactive pseudogene%3B Localized in the cytoplasm%3B~Hypothetical protein gene gene4429 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4429 ZOBELLIA_443 ZOBELLIA_443 ZOBELLIA_443 569780 570466 + Hypothetical protein Localized in the cytoplasm gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_443 ZOBELLIA_4430 ZOBELLIA_4430 ZOBELLIA_4430 5144624 5144779 + Putative protein Hypothetical protein gene gene4430 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4430 ZOBELLIA_4431 ZOBELLIA_4431 ZOBELLIA_4431 5144931 5145434 - Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4431 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4431 ZOBELLIA_4432 ZOBELLIA_4432 ZOBELLIA_4432 5145589 5146053 - Conserved hypothetical protein Localized in the cytoplasm gene gene4432 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4432 ZOBELLIA_4433 ZOBELLIA_4433 ZOBELLIA_4433 5146673 5147122 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4433 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4433 ZOBELLIA_4434 ZOBELLIA_4434 ZOBELLIA_4434 5147177 5147710 - RibD C-terminal domain family protein Protein homologous to the C-terminal domain of the deaminase-reductase RidB. The exact function of this protein is unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene4434 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4434 ZOBELLIA_4435 ZOBELLIA_4435 hdc hdc 5147863 5148981 - Histidine decarboxylase Histidine decarboxylase catalyzes the decarboxylation of L-histidine releasing histamine%2C a siderophore precursor. This enzyme covalently binds the cofactor pyridoxal-phosphate (PLP) on a conserved lysine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4435 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4435 ZOBELLIA_4436 ZOBELLIA_4436 ZOBELLIA_4436 5149140 5149592 + AsnC/Lrp-type transcriptional regulator The AsnC/Lrp-type transcriptional regulator family appears to be an important regulatory system of the amino acid metabolism and related processes%3B Contains a N-terminal DNA binding AsnC/Lrp-type HTH domain. The C-terminal part contains an effector-binding domain and/or an oligomerization domain%3B Localized in the cytoplasm%3B~Family membership gene gene4436 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4436 ZOBELLIA_4437 ZOBELLIA_4437 ZOBELLIA_4437 5149661 5150461 - Conserved hypothetical protein Localized in the cytoplasm gene gene4437 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4437 ZOBELLIA_4438 ZOBELLIA_4438 ZOBELLIA_4438 5150685 5151569 - Conserved hypothetical protein Localized in the cytoplasm gene gene4438 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4438 ZOBELLIA_4439 ZOBELLIA_4439 ZOBELLIA_4439 5151760 5152311 - Conserved hypothetical protein Localized in the cytoplasm gene gene4439 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4439 ZOBELLIA_444 ZOBELLIA_444 ZOBELLIA_444 570610 571047 + hypothetical Lipoprotein Signal peptide cleaved between the residues 15 and 16: Lipoprotein localized in the outer membrane%3B~Hypothetical protein gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_444 ZOBELLIA_4440 ZOBELLIA_4440 ZOBELLIA_4440 5152457 5153233 - LuxR-type transcriptional regulator Transcriptional regulator belonging to the LuxR family. Features a C-terminal helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Specificity unclear gene gene4440 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4440 ZOBELLIA_4441 ZOBELLIA_4441 ZOBELLIA_4441 5153349 5154266 - Long chain dehydrogenase/reductase The long chain dehydrogenases/reductases are zinc-containing enzymes. Zinc-dependant enzymes are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit where one of the zinc atom is essential for catalytic activity while the other is not. The catalytic zinc is coordinated by two cysteines and one histidine%3B Contains a C-terminal domain having a classical Rossman-fold that reversibly binds NAD(H)%3B The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold%3B Localized in the cytoplasm%3B~Family membership gene gene4441 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4441 ZOBELLIA_4442 ZOBELLIA_4442 ZOBELLIA_4442 5154546 5155262 - Peroxiredoxin Peroxiredoxins are thiol peroxidase. They are involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. It attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin. Localized in the cytoplasm.%3B~Specificity unclear gene gene4442 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4442 ZOBELLIA_4443 ZOBELLIA_4443 ZOBELLIA_4443 5155693 5156730 - Long chain dehydrogenase/reductase The long chain dehydrogenases/reductases are zinc-containing enzymes. Zinc-dependant enzymes are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit where one of the zinc atom is essential for catalytic activity while the other is not. The catalytic zinc is coordinated by two cysteines and one histidine%3B Contains a C-terminal domain having a classical Rossman-fold that reversibly binds NAD(H)%3B The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold%3B Localized in the cytoplasm%3B~Family membership gene gene4443 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4443 ZOBELLIA_4444 ZOBELLIA_4444 aldB aldB 5156782 5158098 - Alpha-acetolactate decarboxylase Alpha-acetolactate decarboxylase is involved in ketone and acetoin biosynthesis. It converts acetolactate into acetoin: (S)-2-hydroxy-2-methyl-3-oxobutanoate %3D (R)-2-acetoin + CO2. Displays a C-terminal domain of unknown function. Features a signal peptide cleaved between the residues 20 and 21. Localized in the periplasm.%3B~High confidence in function and specificity gene gene4444 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4444 ZOBELLIA_4445 ZOBELLIA_4445 ZOBELLIA_4445 5158111 5159085 - Permease This family of integral membrane proteins are predicted to be permeases of unknown specificity (DUF318 family)%3B Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4445 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4445 ZOBELLIA_4446 ZOBELLIA_4446 ZOBELLIA_4446 5159078 5159485 - OsmC-like protein Protein belonging to the OsmC family consisting of proteins involved in the stress and detoxification process%3B Localized in the cytoplasm%3B~Family membership gene gene4446 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4446 ZOBELLIA_4447 ZOBELLIA_4447 ZOBELLIA_4447 5159496 5159732 - Thioredoxin-like protein Protein homologous to thioredoxins%2C glutaredoxins%2C and protein disulphide isomerases%2C and shares with them a redox-active disulphide. Localized in the cytoplasm.%3B~Family membership gene gene4447 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4447 ZOBELLIA_4448 ZOBELLIA_4448 ZOBELLIA_4448 5159850 5159978 - Putative protein Hypothetical protein gene gene4448 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4448 ZOBELLIA_4449 ZOBELLIA_4449 ZOBELLIA_4449 5160185 5160394 - Putative protein Hypothetical protein gene gene4449 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4449 ZOBELLIA_445 ZOBELLIA_445 ZOBELLIA_445 571368 571763 + Hypothetical protein Contains one transmebrane segment%3B Signal peptide cleaved between the residues 19 and 20%3B Protein localized in the cytoplasmic membrane gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_445 ZOBELLIA_4450 ZOBELLIA_4450 ZOBELLIA_4450 5160408 5161400 - Sodium-dependent transporter Protein belonging to the Sodium Bile acid symporter family%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene4450 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4450 ZOBELLIA_4451 ZOBELLIA_4451 ZOBELLIA_4451 5161594 5161686 - Putative protein Hypothetical protein gene gene4451 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4451 ZOBELLIA_4452 ZOBELLIA_4452 ZOBELLIA_4452 5161791 5162054 + Putative protein Hypothetical protein gene gene4452 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4452 ZOBELLIA_4453 ZOBELLIA_4453 ZOBELLIA_4453 5162057 5162635 + YceI family protein Protein Belongs to the YceI (UPF0312) family%2C type 1 subfamily%3B Signal peptide cleaved between the residues 25 and 26%3B Localized in the periplasmic space%3B~Family membership gene gene4453 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4453 ZOBELLIA_4454 ZOBELLIA_4454 ZOBELLIA_4454 5162671 5163939 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4454 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4454 ZOBELLIA_4455 ZOBELLIA_4455 ZOBELLIA_4455 5164046 5164636 + YceI family protein Protein Belongs to the YceI (UPF0312) family%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Family membership gene gene4455 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4455 ZOBELLIA_4456 ZOBELLIA_4456 ZOBELLIA_4456 5165382 5165489 + Putative protein Hypothetical protein gene gene4457 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4456 ZOBELLIA_4457 ZOBELLIA_4457 ZOBELLIA_4457 5164722 5165390 - Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4456 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4457 ZOBELLIA_4458 ZOBELLIA_4458 ZOBELLIA_4458 5165678 5166295 - Conserved hypothetical protein Localized in the cytoplasm gene gene4458 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4458 ZOBELLIA_4459 ZOBELLIA_4459 ZOBELLIA_4459 5166743 5167192 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4459 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4459 ZOBELLIA_446 ZOBELLIA_446 ZOBELLIA_446 571735 571869 - Putative protein Hypothetical protein gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_446 ZOBELLIA_4460 ZOBELLIA_4460 ZOBELLIA_4460 5167492 5168490 + Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartate acid%2C and an histidine. The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Function unclear gene gene4460 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4460 ZOBELLIA_4461 ZOBELLIA_4461 ZOBELLIA_4461 5168570 5169850 - Serine peptidase%2C family S12 Protein belonging to the family 12 of serine peptidases (S12). The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa-Thr-Lys%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~Function unclear gene gene4461 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4461 ZOBELLIA_4462 ZOBELLIA_4462 ZOBELLIA_4462 5170080 5171285 + Conserved hypothetical protein Protein belonging to the DUF1006 family%3B Localized in the cytoplasm%3B~Family membership gene gene4462 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4462 ZOBELLIA_4463 ZOBELLIA_4463 fosB fosB 5171333 5171740 + Metallothiol transferase FosB Metallothiol transferase confers resistance to fosfomycin by catalyzing the addition of a thiol group to fosfomycin. L-cysteine is probably the physiological thiol donor%3B Forms a homodimer%3B Binds a magnesium ion as cofactor per subunit%3B elongs to the Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4463 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4463 ZOBELLIA_4464 ZOBELLIA_4464 ZOBELLIA_4464 5171814 5172686 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4464 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4464 ZOBELLIA_4465 ZOBELLIA_4465 ytfG ytfG 5172798 5173643 + Uncharacterized oxidoreductase YtfG YtfG belongs to the NmrA-type oxidoreductase family%2C but its exact function is unknown%3B Localized in the cytoplasm%3B~Family membership gene gene4465 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4465 ZOBELLIA_4466 ZOBELLIA_4466 ZOBELLIA_4466 5173815 5174312 + Glyoxalase superfamily protein Protein Belongs to the Glyoxalase superfamily protein%3B Localized in the cytoplasm%3B~Function unclear gene gene4466 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4466 ZOBELLIA_4467 ZOBELLIA_4467 ZOBELLIA_4467 5174518 5175381 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4467 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4467 ZOBELLIA_4468 ZOBELLIA_4468 ZOBELLIA_4468 5175388 5175753 + Conserved hypothetical protein Protein with a Dimeric alpha-beta barrel domain that exhibit an alpha+beta sandwich fold with an antiparallel beta sheet that forms a closed barrel. These domains dimerise through the beta-sheet%2C and in some cases these dimers may assemble into higher oligomers%3B Localized in the cytoplasm gene gene4468 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4468 ZOBELLIA_4469 ZOBELLIA_4469 ZOBELLIA_4469 5175753 5175863 + Putative protein Hypothetical protein gene gene4469 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4469 ZOBELLIA_447 ZOBELLIA_447 ZOBELLIA_447 572135 573184 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_447 ZOBELLIA_4470 ZOBELLIA_4470 ZOBELLIA_4470 5176124 5176798 + Fatty acid hydroxylase family protein Protein belonging to the Fatty acid hydroxylase family%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4470 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4470 ZOBELLIA_4471 ZOBELLIA_4471 ZOBELLIA_4471 5176802 5178652 + 3-oxoacyl-[acyl-carrier-protein] synthase III Modular protein with a N-terminal 3-oxoacyl-[acyl-carrier-protein] synthase III domain and a C-terminal domain of unknown function (211 residues). The 3-oxoacyl-[acyl-carrier-protein] synthase III%2C also known as beta-ketoacyl-ACP synthase III%2C catalyses the first condensation reaction in the fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4471 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4471 ZOBELLIA_4472 ZOBELLIA_4472 ZOBELLIA_4472 5178662 5179558 + Conserved hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4472 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4472 ZOBELLIA_4473 ZOBELLIA_4473 ZOBELLIA_4473 5179606 5179989 - HxlR-type transcriptional regulator Transcriptional regulator belonging to the HxlR family. Features a helix-turn-helix DNA binding motif. Localized in the cytoplasm.%3B~Specificity unclear gene gene4473 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4473 ZOBELLIA_4474 ZOBELLIA_4474 nfnB1 nfnB1 5180232 5180885 + 6%2C7-dihydropteridine reductase Also called oxygen-insensitive NAD(P)H nitroreductase this enzyme reduces a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents%2C two electrons are transferred. Capable of reducing nitrofurazone%2C quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2%2C4-dinitrobenzamide)%3B Uses the FMN as cofactor%3B Belongs to the nitroreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4474 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4474 ZOBELLIA_4475 ZOBELLIA_4475 lipA lipA 5180909 5181829 + Triacylglycerol lipase Protein that could be a lipase%3B Belongs to the alpha/beta hydrolase superfamily characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine and to the lipase/esterase LIP3/bchO family%3B localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4475 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4475 ZOBELLIA_4476 ZOBELLIA_4476 ZOBELLIA_4476 5181832 5182683 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene4476 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4476 ZOBELLIA_4477 ZOBELLIA_4477 ZOBELLIA_4477 5182715 5183338 + Antibiotic biosynthesis monooxygenase family protein Protein containing two consecutive domains Localized in the cytoplasm%3B~Family membership gene gene4477 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4477 ZOBELLIA_4478 ZOBELLIA_4478 alsD alsD 5183372 5184229 + Alpha-acetolactate decarboxylase Alpha-acetolactate decarboxylase converts acetolactate into acetoin%2C which can be secreted by the cells. This may be a mechanism for controlling the internal pH of cells in the stationary stage%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in cytoplasmic and/or the outer membrane%3B~High confidence in function and specificity gene gene4478 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4478 ZOBELLIA_4479 ZOBELLIA_4479 pcaC pcaC 5184237 5185799 + 4-Carboxymuconolactone decarboxylase Modular protein displaying a N-terminal 4-carboxymuconolactone decarboxylase (CMD) domain and a C-terminal conserved domain of unknown function. CMD is involved in protocatechuate catabolism. It converts the 2-carboxy-2%2C5-dihydro-5-oxofuran-2-acetate to 4%2C5-dihydro-5-oxofuran-2-acetate%3B Localized in the cytoplasm:%3B~High confidence in function and specificity gene gene4479 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4479 ZOBELLIA_448 ZOBELLIA_448 ZOBELLIA_448 573196 573756 + LemA family protein Conserved protein belonging to the LemA family. In Listeria monocytogenes LemA corresponds to a H2-M3-restricted epitope. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_448 ZOBELLIA_4480 ZOBELLIA_4480 qorA1 qorA1 5185819 5186757 + Quinone oxidoreductase The NADP-dependent quinone oxidoreductase catalyzes the one-electron reduction of certain quinines%3B orthoquinones are the best substrates. It is an enzyme found in bacteria%2C in yeast and in mammals where%2C in some species such as rodents%2C it has been recruited as an eye lens protein and is known as zeta-crystallin%3B Belongs to the zinc-containing alcohol dehydrogenase family%2C Quinone oxidoreductase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4480 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4480 ZOBELLIA_4481 ZOBELLIA_4481 ZOBELLIA_4481 5186777 5188273 + NAD dependent aldehyde dehydrogenase Aldehyde dehydrogenases are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor.A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this family.Located in the cytoplasm.%3B~Family membership gene gene4481 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4481 ZOBELLIA_4482 ZOBELLIA_4482 ZOBELLIA_4482 5188302 5188445 + Putative protein Hypothetical protein gene gene4482 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4482 ZOBELLIA_4483 ZOBELLIA_4483 ZOBELLIA_4483 5188463 5189083 + Multiple antibiotic resistance (MarC)-related protein Members of this family are integral membrane proteins that includes the antibiotic resistance protein MarC. These proteins may be transporters%3B Belongs to the marC (UPF0056) family%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4483 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4483 ZOBELLIA_4484 ZOBELLIA_4484 ZOBELLIA_4484 5189110 5189487 + Conserved hypothetical protein Localized in the cytoplasm gene gene4484 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4484 ZOBELLIA_4485 ZOBELLIA_4485 ZOBELLIA_4485 5189547 5190023 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4485 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4485 ZOBELLIA_4486 ZOBELLIA_4486 lexA lexA 5190031 5190795 - LexA repressor%2C family S24 LexA represses a number of genes involved in the response to DNA damage (SOS response)%2C including recA and lexA. It displays a N-terminal Helix-Turn-Helix DNA binding domain and a C-terminal serine peptidase domain of the family S24. The HTH domain binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA%2C RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of lexA%2C leading to derepression of the SOS regulon and eventually DNA repair. The active site of the S24 domain consists of a Ser%2C Lys catalytic dyad and the cleavage occurs at an Ala-Gly or a Cys-Gly bond. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4486 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4486 ZOBELLIA_4487 ZOBELLIA_4487 ZOBELLIA_4487 5190963 5192228 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4487 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4487 ZOBELLIA_4488 ZOBELLIA_4488 ZOBELLIA_4488 5192273 5193046 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4488 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4488 ZOBELLIA_4489 ZOBELLIA_4489 uvrA2 uvrA2 5193238 5196078 + Excinuclease ABC%2C subunit A The UvrA protein belongs to the UvrABC repair system responsible of the recognition and processing of DNA lesions%3B UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Contains 2 ABC transporter domains%3B Belongs to the ABC transporter family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4489 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4489 ZOBELLIA_449 ZOBELLIA_449 ZOBELLIA_449 573740 574126 + Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_449 ZOBELLIA_4490 ZOBELLIA_4490 ZOBELLIA_4490 5196121 5196669 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4490 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4490 ZOBELLIA_4491 ZOBELLIA_4491 ZOBELLIA_4491 5196855 5197541 + Conserved hypothetical protein Localized in the cytoplasm gene gene4491 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4491 ZOBELLIA_4492 ZOBELLIA_4492 ZOBELLIA_4492 5197541 5200405 + Non-peptidase protein%2C Family M1 Protein displaying similarity with the metallopeptidases of the family 1 (M1)%2C but lacking the catalytic HEXXH motif%3B Contains a C-terminal domain of unknown function%3B Signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Family membership gene gene4492 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4492 ZOBELLIA_4493 ZOBELLIA_4493 bkdA2 bkdA2 5200568 5202979 + 2-Oxoisovalerate dehydrogenase%2C E1 component The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine%2C leucine and isoleucine biodegradation. This complex contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 component displays a modular architecture. The N-terminal domain is a dehydrogenase and the C-terminal domain belongs to the transketolase family. Both activities uses thiamine pyrophosphate as prosthetic group%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4493 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4493 ZOBELLIA_4494 ZOBELLIA_4494 ZOBELLIA_4494 5203125 5203499 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Belongs to the DoxX family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4494 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4494 ZOBELLIA_4495 ZOBELLIA_4495 ZOBELLIA_4495 5203509 5204510 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4495 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4495 ZOBELLIA_4496 ZOBELLIA_4496 ZOBELLIA_4496 5204489 5204638 - Putative protein Hypothetical protein gene gene4496 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4496 ZOBELLIA_4497 ZOBELLIA_4497 ZOBELLIA_4497 5204666 5204983 + Conserved hypothetical protein Localized in the cytoplasm gene gene4497 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4497 ZOBELLIA_4498 ZOBELLIA_4498 ZOBELLIA_4498 5204996 5205997 + Glycosyl transferase%2C family GT 2 Glycosyl transferase possibly involved in the cell wall biosynthesis%3B Belongs to the family 2 of glycosyl transferases (GT2)%3B Localized in the cytoplasm%3B~Family membership gene gene4498 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4498 ZOBELLIA_4499 ZOBELLIA_4499 ZOBELLIA_4499 5206101 5206949 + OmpA-like lipoprotein Protein containing a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Family membership gene gene4499 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4499 ZOBELLIA_45 ZOBELLIA_45 ZOBELLIA_45 45391 45978 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_45 ZOBELLIA_450 ZOBELLIA_450 ZOBELLIA_450 574235 575023 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_450 ZOBELLIA_4500 ZOBELLIA_4500 ZOBELLIA_4500 5207047 5207895 - Putative membrane lipoprotein Lipoprotein signal peptide cleaved between the residues 19 and 20%3B Putatively localized in the outer membrane%3B~Hypothetical protein gene gene4500 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4500 ZOBELLIA_4501 ZOBELLIA_4501 ZOBELLIA_4501 5207902 5210310 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (35-114) and the Plug module (130-237) acting as a channel gate%3B The signal peptide is cleaved between the residues 31 and 32%3B~Family membership gene gene4501 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4501 ZOBELLIA_4502 ZOBELLIA_4502 ZOBELLIA_4502 5210558 5211100 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene4502 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4502 ZOBELLIA_4503 ZOBELLIA_4503 ZOBELLIA_4503 5211100 5211639 + Conserved hypothetical membrane protein Contains a central transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4503 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4503 ZOBELLIA_4504 ZOBELLIA_4504 ZOBELLIA_4504 5211614 5212711 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4504 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4504 ZOBELLIA_4505 ZOBELLIA_4505 ZOBELLIA_4505 5212948 5213616 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4505 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4505 ZOBELLIA_4506 ZOBELLIA_4506 ZOBELLIA_4506 5213673 5213807 + Conserved hypothetical protein Localized in the cytoplasm gene gene4506 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4506 ZOBELLIA_4507 ZOBELLIA_4507 ZOBELLIA_4507 5213865 5214587 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4507 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4507 ZOBELLIA_4508 ZOBELLIA_4508 hisIE hisIE 5214595 5215194 - Histidine biosynthesis bifunctional protein HisIE HisIE is a bifunctional enzyme containing a N-terminal phosphoribosyl-AMP cyclohydrolase (PRA-CH) domain and a C-terminal phosphoribosyl-ATP pyrophosphatase (PRA-PH) domain%2C catalyzing the third and second steps of the L-histidine biosynthetic pathway%2C respectively. PRA-CH catalyzes the reaction: 1-(5-phosphoribosyl)-AMP + H2O %3D 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. It requires Zn ions for activity. PRA-PH catalyzes the reaction: 1-(5-phosphoribosyl)-ATP + H2O %3D 1-(5-phosphoribosyl)-AMP + diphosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4508 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4508 ZOBELLIA_4509 ZOBELLIA_4509 hisF hisF 5215251 5216006 - Imidazole glycerol phosphate synthase subunit HisF Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step in the L-histidine biosynthetic pathway%2C the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. IGPS is a heterodimer of HisF and HisH subunits. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4509 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4509 ZOBELLIA_451 ZOBELLIA_451 ZOBELLIA_451 575204 575473 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Hypothetical protein gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_451 ZOBELLIA_4510 ZOBELLIA_4510 hisA hisA 5216071 5216850 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase HisA catalyzes the fourth step in the L-histidine biosynthetic pathway: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide %3D 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. It forms a monomer and adopts a TIM barrel fold. Display distant similarity with HisF. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4510 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4510 ZOBELLIA_4511 ZOBELLIA_4511 ZOBELLIA_4511 5216979 5217329 - Bacterial 23S rRNA protein The function of this protein is not known%2C but a structural study indicates that each momonmer folds into an antiparallel four-helix bundle%2C while the overall protein is a homopentamer with a toroid-shaped structure containing a tapered central channel%3B Belongs to the bacterial 23S rRNA proteins family%3B Localized in the cytoplasm%3B~Family membership gene gene4511 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4511 ZOBELLIA_4512 ZOBELLIA_4512 hisH hisH 5217367 5217954 - Imidazole glycerol phosphate synthase subunit HisH Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step in the L-histidine biosynthetic pathway%2C the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. IGPS is a heterodimer of HisF and HisH subunits. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4512 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4512 ZOBELLIA_4513 ZOBELLIA_4513 hisB hisB 5218031 5219167 - Histidine biosynthesis bifunctional protein HisB HisB is a bifunctional enzyme containing a N-terminal histidinol-phosphatase (HP) domain and a C-terminal imidazoleglycerol-phosphate dehydratase (IGPD) domain%2C catalyzing the eighth and sixth steps of L-histidine biosynthetic pathway%2C respectively. HP catalyzes the dephosphorylation of L-histidinol phosphate. HP forms a homodimer in solution. The active site contains two metal binding sites. IGPD catalyzes the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate %3D 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. IGPD is a metalloenzyme in which transition metals induce aggregation and are required for catalysis. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4513 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4513 ZOBELLIA_4514 ZOBELLIA_4514 hisC hisC 5219187 5220236 - Histidinol-phosphate aminotransferase The histidinol-phosphate aminotransferase catalyses the transfer of an amino group from 3-(imidazol-4-yl)-2-oxopropyl phosphate to glutamic acid to form histidinol phosphate and 2-oxoglutarate using the Pyridoxal phosphate as cofactor bound by covalent linkage to a lysine residue. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4514 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4514 ZOBELLIA_4515 ZOBELLIA_4515 hisD hisD 5220229 5221518 - Histidinol dehydrogenase Histidinol dehydrogenase catalyzes the terminal step in the biosynthesis of histidine%2C the four-electron oxidation of L-histidinol to histidine. A single active site catalyzes 2 separate oxidation steps: oxidation of the substrate alcohol to an intermediate aldehyde%3B and oxidation of the aldehyde to the product acid. The reaction proceeds via a tightly- or covalently-bound inter- mediate%2C and requires the presence of 2 NAD molecules. It forms a homodimer and binds also one zinc ion per subunit as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4515 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4515 ZOBELLIA_4516 ZOBELLIA_4516 ZOBELLIA_4516 5221515 5222000 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule. Belongs to Gcn5 or GNAT actyltransferase family. Localized in the cytoplasm.%3B~Specificity unclear gene gene4516 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4516 ZOBELLIA_4517 ZOBELLIA_4517 hisG hisG 5221973 5222830 - ATP phosphoribosyltransferase ATP phosphoribosyltransferase catalyzes the condensation of ATP and PRPP to form N'-5'-phosphoribosyl-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Exist in equilibrium between an active dimeric form%2C an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme. Binds a magnesium ion per subunit as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4517 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4517 ZOBELLIA_4518 ZOBELLIA_4518 ZOBELLIA_4518 5222961 5223053 + Putative protein Hypothetical protein gene gene4518 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4518 ZOBELLIA_4519 ZOBELLIA_4519 ZOBELLIA_4519 5223067 5223879 - Prohibitin-like protein Conserved protein%3B~Family membership gene gene4519 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4519 ZOBELLIA_452 ZOBELLIA_452 ZOBELLIA_452 575619 576638 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_452 ZOBELLIA_4520 ZOBELLIA_4520 ZOBELLIA_4520 5223890 5225920 - Conserved hypothetical membrane protein Contains two N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4520 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4520 ZOBELLIA_4521 ZOBELLIA_4521 fabG1 fabG1 5225985 5226731 - 3-oxoacyl-[acyl-carrier protein] reductase FabG is involved in first reduction step of the fatty acid biosynthesis pathway. Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4521 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4521 ZOBELLIA_4522 ZOBELLIA_4522 sucD sucD 5226847 5227719 - Succinyl-CoA ligase [ADP-forming] subunit alpha Succinyl-CoA ligase functions in the citric acid cycle%2C coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents an important site of substrate-level phosphorylation. It can also function in the other direction for anabolic purposes. It forms a heterotetramer of two alpha and two beta subunits. The alpha subunit binds CoA%2C as well as ATP and catalyzes phosphoryl transfer to one of its histidine residues. The complete active site is probably located in the region of alpha-beta contact. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4522 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4522 ZOBELLIA_4523 ZOBELLIA_4523 lpxD1 lpxD1 5227790 5228722 - UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD catalyzes the third step of lipid A biosynthesis%3B LpxD features eight tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which has been shown to fold as a left-handed parallel beta helix%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4523 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4523 ZOBELLIA_4524 ZOBELLIA_4524 efp efp 5228788 5229354 - Elongation factor P Elongation factor P is involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA%2C thus increasing their reactivity as acceptors for peptidyl transferase. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4524 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4524 ZOBELLIA_4525 ZOBELLIA_4525 lpxA lpxA 5229441 5230226 - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase LpxA catalyzes the first step of lipid A biosynthesis. LpxA features seven tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which has been shown to fold as a left-handed parallel beta helix%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4525 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4525 ZOBELLIA_4526 ZOBELLIA_4526 lpxC/fabZ4 lpxC/fabZ4 5230228 5231613 - UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase Modular protein consisting of a N-terminal UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine deacetylase domain (LpxC) and a C-terminal (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase domain (FabZ). LpxC catalyzes the second step of lipid A biosynthesis converting the UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine into UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine. LpxC is a zinc-dependent enzyme which belongs to the family 11 of the carbohydrate esterases (CE11). FabZ catalyzes the third step of the fatty acid elongation cycle (type II fatty acid biosynthesis) converting the (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] into tetradecenoyl-[acyl-carrier protein]. FabZ adopts a thioesterase fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4526 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4526 ZOBELLIA_4527 ZOBELLIA_4527 lpxD2 lpxD2 5231594 5232643 - UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD catalyzes the third step of lipid A biosynthesis%3B LpxD features eight tandem repeats of a [LIV]-G-X(4) hexapeptide%2C which has been shown to fold as a left-handed parallel beta helix%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4527 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4527 ZOBELLIA_4528 ZOBELLIA_4528 ZOBELLIA_4528 5232667 5233770 - Phosphohydrolase family protein Conserved protein belonging to the metal-dependent phosphohydrolase family. Localized in the cytoplasm.%3B~Family membership gene gene4528 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4528 ZOBELLIA_4529 ZOBELLIA_4529 ZOBELLIA_4529 5234041 5235582 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain%2C here a PglZ domain%2C a member of Alkaline phosphatase clan%3B Localized in the cytoplasm%3B~Family membership gene gene4529 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4529 ZOBELLIA_453 ZOBELLIA_453 ZOBELLIA_453 577319 577894 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the cytoplasmic and/or outer membranes%3B~Hypothetical protein gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_453 ZOBELLIA_4530 ZOBELLIA_4530 ZOBELLIA_4530 5235595 5236008 + ATPase%2C UPF0079 family This protein belongs to the UPF0079 family. This group consists of bacterial proteins%2C which contain a P-loop. They are probably essential to bacteria as members are found in all genomes so far sequenced and no equivalent genes have been found in the archaea and eukaryotes. These proteins adopt a nucleotide-binding fold with a four-stranded parallel beta-sheet flanked by antiparallel beta-strands on each side. The topology of the beta-sheet is unique among P-loop proteins and has features of different families of enzymes. ADP has been shown to bind to the P-loop in the presence of Mg2+ and ATPase activity has been confirmed by kinetic measurements. Localized in the cytoplasm.%3B~Specificity unclear gene gene4530 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4530 ZOBELLIA_4531 ZOBELLIA_4531 ZOBELLIA_4531 5236175 5236423 + Putative membrane lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 26 and 27%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4531 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4531 ZOBELLIA_4532 ZOBELLIA_4532 ZOBELLIA_4532 5236522 5237199 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4532 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4532 ZOBELLIA_4533 ZOBELLIA_4533 aldA aldA 5237305 5238504 + Alanine dehydrogenase Alanine dehydrogenase is a key factor in the assimilation of L-alanine as an energy source through the tricarboxylic acid. It converts L-alanine to pyruvate and ammoniac. It forms a homohexamer and binds one NAD+ per subunit as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4533 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4533 ZOBELLIA_4534 ZOBELLIA_4534 ZOBELLIA_4534 5238650 5239033 + Conserved hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4534 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4534 ZOBELLIA_4535 ZOBELLIA_4535 ZOBELLIA_4535 5239073 5240239 - Carbapenem antibiotics biosynthesis protein carD CarD is involved in carbapenem antibiotic biosynthesis%2C but its exact function is unknown. Belongs to the proline dehydrogenase family and likely binds a FAD as a cofactor. Localized in the cytoplasm.%3B~Function unclear gene gene4535 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4535 ZOBELLIA_4536 ZOBELLIA_4536 aroB2 aroB2 5240370 5241434 + 3-Dehydroquinate synthase 3-Dehydroquinate synthase is involved in the biosynthesis of aromatic amino acids. It catalyzes the second step of the shikimate pathway%2C the formation of dehydroquinate and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. It forms a monomer and binds NAD and divalent metal cation as cofactors. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4536 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4536 ZOBELLIA_4537 ZOBELLIA_4537 ZOBELLIA_4537 5241566 5241892 + Conserved hypothetical protein Localized in the cytoplasm. gene gene4537 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4537 ZOBELLIA_4538 ZOBELLIA_4538 ZOBELLIA_4538 5241912 5242430 - Conserved hypothetical protein Localized in the cytoplasm gene gene4538 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4538 ZOBELLIA_4539 ZOBELLIA_4539 asnC3 asnC3 5242503 5242982 - Transcriptional regulator AsnC The transcriptional regulator AsnC is the activator of the asnA gene involved in the asparagine synthesis and is a autogenous regulator of its own transcription%3B Contains a N-terminal AsnC/Lrp-type HTH domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4539 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4539 ZOBELLIA_454 ZOBELLIA_454 ZOBELLIA_454 577901 580672 - Conserved hypothetical protein Conserved protein belonging to the DUF608 family%3B Contains a signal peptide cleaved between the residues 37 and 38%3B Localized in the periplasmic space gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_454 ZOBELLIA_4540 ZOBELLIA_4540 ZOBELLIA_4540 5243098 5244207 - Metallopeptidase%2C family M14 Peptidase family M14 contains mainly metallocarboxypeptidases. The single catalytic zinc ion is tetrahedrally coordinated by two histidines and a glutamate%2C as well as a water molecule. One of the histidines and the glutamate occur in the motif His-Xaa-Xaa-Glu%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4540 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4540 ZOBELLIA_4541 ZOBELLIA_4541 ZOBELLIA_4541 5244499 5244882 + Cro/C1-type transcriptional regulator Transcriptional regulator with a helix-turn-helix DNA-binding motif located in the N-terminal part. The C-terminal part may contain an oligomerization domain%3B Belongs to the Cro/C1-type transcriptional regulator family%3B Localized in the cytoplasm%3B~Family membership gene gene4541 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4541 ZOBELLIA_4542 ZOBELLIA_4542 ZOBELLIA_4542 5244851 5245285 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4542 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4542 ZOBELLIA_4543 ZOBELLIA_4543 ZOBELLIA_4543 5245355 5245498 - Putative protein Hypothetical protein gene gene4543 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4543 ZOBELLIA_4544 ZOBELLIA_4544 ZOBELLIA_4544 5245639 5246595 - Fatty acid hydroxylase family protein Conserved protein belonging to the Fatty acid hydroxylase family which includes fatty acid and carotene hydroxylases and sterol desaturases%3B Contains three transmembrane helices%3B Localized in the cytoplasmic membrane.%3B~Family membership gene gene4544 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4544 ZOBELLIA_4545 ZOBELLIA_4545 parC parC 5246852 5249587 - DNA topoisomerase IV%2C subunit A DNA topoisomerase IV is essential for chromosome segregation. In an ATP-dependent manner%2C it acts to relax positive supercoils in DNA and performs the decatenation events required during the replication of a circular DNA molecule%3B DNA topoisomerase IV is composed of two subunits parC and parE%3B Belongs to the type-II topoisomerase family%2C type-IIA subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4545 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4545 ZOBELLIA_4546 ZOBELLIA_4546 parE parE 5249613 5251475 - DNA topoisomerase IV%2C subunit B DNA topoisomerase IV is essential for chromosome segregation. In an ATP-dependent manner%2C It acts to relax positive supercoils in DNA and performs the decatenation events required during the replication of a circular DNA molecule%3B DNA topoisomerase IV is composed of two subunits parC and parE%3B Belongs to the type-II topoisomerase family%2C type-IIA subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4546 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4546 ZOBELLIA_4547 ZOBELLIA_4547 cpsA2 cpsA2 5251735 5253012 + Carboxypeptidase%2C family M20 Carboxypeptidase catalyzes the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides. This enzyme can release basic%2C acidic%2C aromatic%2C and%2C to a lesser extent%2C aliphatic amino acids. Belongs to the family M20 of the metallopeptidase. CpsA binds two co-catalytic zinc ions%2C which are coordinated by five conserved residues (His/Asp%2C Asp%2C Glu%2C Glu/Asp%2C His). The zinc ions stabilize the tetrahedral intermediate and activate the catalytic water molecule. Features a signal peptide cleaved between the residues 20 and 21. Localized in the periplasm.%3B~High confidence in function and specificity gene gene4547 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4547 ZOBELLIA_4548 ZOBELLIA_4548 ZOBELLIA_4548 5253062 5254636 + FMN / Fe-S cluster binding protein Conserved protein Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4548 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4548 ZOBELLIA_4549 ZOBELLIA_4549 ZOBELLIA_4549 5254705 5255475 + OmpA-like periplasmic protein Conserved protein containing a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space and/or in the outer membrane%3B~Family membership gene gene4549 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4549 ZOBELLIA_455 ZOBELLIA_455 ZOBELLIA_455 580708 581559 - Hypothetical periplasmic protein Containsa signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_455 ZOBELLIA_4550 ZOBELLIA_4550 ZOBELLIA_4550 5255551 5256072 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4550 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4550 ZOBELLIA_4551 ZOBELLIA_4551 ZOBELLIA_4551 5256139 5257059 - Phospholipase%2C Patatin family This protein belongs to a phospholipase family including the Patatin%2C a lipid acyl hydrolase%2C catalysing the cleavage of fatty acids from membrane lipids. Localized in the cytoplasm.%3B~Specificity unclear gene gene4551 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4551 ZOBELLIA_4552 ZOBELLIA_4552 ZOBELLIA_4552 5257063 5259123 - Aminopeptidase%2C family M1 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. This enzyme belongs to the family M1 of the peptidases. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm.%3B~Specificity unclear gene gene4552 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4552 ZOBELLIA_4553 ZOBELLIA_4553 recG recG 5259202 5261307 + ATP-dependent DNA helicase RecG RecG plays a critical role in recombination and DNA repair. It helps process Holliday junction intermediates to mature products by catalyzing branch migration. Acts as a DNA helicase with a 3' to 5' polarity. RecG unwind branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (csdR) and R-loop formation%3B Belongs to the DEAD and DEAH helicase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4553 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4553 ZOBELLIA_4554 ZOBELLIA_4554 ZOBELLIA_4554 5261362 5261487 + Putative protein Hypothetical protein gene gene4554 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4554 ZOBELLIA_4555 ZOBELLIA_4555 ZOBELLIA_4555 5261528 5262298 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4555 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4555 ZOBELLIA_4556 ZOBELLIA_4556 leuC leuC 5262655 5264070 + 3-Isopropylmalate dehydratase%2C large subunit 3-Isopropylmalate dehydratase catalyzes the second step the L-leucine biosynthesis pathway. It converts (2R%2C 3S)-3-isopropylmalate into 3-hydroxy-4-methyl-3-carboxypentanoate%2C via the formation of (2S)-2-isopropylmaleate. Two successive isomerizations are catalyzed: (i) (2R%2C3S)-3-isopropylmalate %3D (2S)-2-isopropylmaleate + H2O and (ii)(2S)-2-isopropylmaleate + H2O %3D 3-hydroxy-4-methyl-3-carboxypentanoate. 3-Isopropylmalate dehydratase. 3-Isopropylmalate dehydratase is a heterodimer of LeuC and LeuD and binds one 4Fe-4S cluster per subunit. LeuC belongs to the aconitase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4556 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4556 ZOBELLIA_4557 ZOBELLIA_4557 leuD leuD 5264110 5264706 + 3-Isopropylmalate dehydratase%2C small subunit 3-Isopropylmalate dehydratase catalyzes the second step the L-leucine biosynthesis pathway. It converts (2R%2C 3S)-3-isopropylmalate into 3-hydroxy-4-methyl-3-carboxypentanoate%2C via the formation of (2S)-2-isopropylmaleate. Two successive isomerizations are catalyzed: (i) (2R%2C3S)-3-isopropylmalate %3D (2S)-2-isopropylmaleate + H2O and (ii)(2S)-2-isopropylmaleate + H2O %3D 3-hydroxy-4-methyl-3-carboxypentanoate. 3-Isopropylmalate dehydratase. 3-Isopropylmalate dehydratase is a heterodimer of LeuC and LeuD. LeuD belongs to the aconitase C-terminal domain family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4557 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4557 ZOBELLIA_4558 ZOBELLIA_4558 leuA1 leuA1 5264838 5266355 + 2-Isopropylmalate synthase 2-Isopropylmalate synthase catalyzes the first step in the L-leucine biosynthesis pathway. LeuA condensates the acetyl group of acetyl-CoA with 3-methyl-2- oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Its features a N-terminal catalytic HMGL-like domain and a C-terminal LeuA-dimerization domain. LeuA forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4558 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4558 ZOBELLIA_4559 ZOBELLIA_4559 LeuB1 LeuB1 5266567 5267622 + 3-Isopropylmalate dehydrogenase 3-Isopropylmalate dehydrogenase catalyzes the third step in the L-leucine biosynthesis pathway. LeuB catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. LeuB forms a homodimer and binds one NAD+ and one Mg2+ or Mn2+ ion by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4559 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4559 ZOBELLIA_456 ZOBELLIA_456 ZOBELLIA_456 581650 584118 - Conserved hypothetical protein Conserved protein belonging to the DUF608 family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_456 ZOBELLIA_4560 ZOBELLIA_4560 ZOBELLIA_4560 5267780 5268355 - Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4560 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4560 ZOBELLIA_4561 ZOBELLIA_4561 ZOBELLIA_4561 5268658 5268891 - Putative protein Hypothetical protein gene gene4561 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4561 ZOBELLIA_4562 ZOBELLIA_4562 ZOBELLIA_4562 5269136 5269972 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4562 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4562 ZOBELLIA_4563 ZOBELLIA_4563 ZOBELLIA_4563 5270208 5271059 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4563 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4563 ZOBELLIA_4564 ZOBELLIA_4564 ZOBELLIA_4564 5271355 5272554 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 12 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4564 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4564 ZOBELLIA_4565 ZOBELLIA_4565 gapN gapN 5272833 5274413 - glyceraldehyde 3-phosphate dehydrogenase%2C NADP-d ependent The NADP-dependent glyceraldehyde-3-phosphate dehydrogenase is important as a means of generating NADPH for biosynthetic reactions. It converts the D-glyceraldehyde 3-phosphate to 3-phospho-D-glycerate%3B Forms a homotetramer and binds a NADP+ per subunit as cofactors%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4565 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4565 ZOBELLIA_4566 ZOBELLIA_4566 ilvA ilvA 5274552 5275802 - Threonine dehydratase Involved in the first step in the pathway converting threonine into isoleucine%2C it catalyzes the formation of alpha-ketobutyrate from threonine in a two- step reaction. The first step is a dehydration of threonine%2C followed by rehydration and liberation of ammonia%3B Uses the pyridoxal phosphate (vitamin B6) as prosthetic group%3B Belongs to the serine/threonine dehydratase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4566 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4566 ZOBELLIA_4567 ZOBELLIA_4567 ilvC ilvC 5275880 5277355 - Ketol-acid reductoisomerase Ketol-acid reductoisomerase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine. IlvC uses NADP(H) as a cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4567 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4567 ZOBELLIA_4568 ZOBELLIA_4568 ilvH ilvH 5277451 5277981 - Acetolactate synthase small subunit Acetolactate synthase is a complex of a large catalytic chain and a smaller regulatory chain associated in an alpha2/beta2 heterotetramer. It catalyzes the first step of the isoleucine and valine biosynthesic pathways. The regulatory subunit%2C IlvH%2C features an ACT domain. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4568 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4568 ZOBELLIA_4569 ZOBELLIA_4569 ZOBELLIA_4569 5278332 5278913 - S-adenosylmethionine-dependent O-methyltransferase O-Methyltransferase binding S-adenosylmethionine as a cofactor. Its substrate specificity is unknown%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4569 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4569 ZOBELLIA_457 ZOBELLIA_457 ZOBELLIA_457 584203 585897 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~Family membership gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_457 ZOBELLIA_4570 ZOBELLIA_4570 ilvB ilvB 5278942 5280675 - Acetolactate synthase%2C large subunit Acetolactate synthase is a complex of a large catalytic chain and a small regulatory chain associated in an alpha2/beta2 heterotetramer. It catalyzes the first step of the isoleucine and valine biosynthesic pathways. The catalytic subunit%2C IlvB%2C is a thiamine pyrophosphate-dependent enzyme. It also binds one magnesium ion and one FAD per subunit%2C although the role of this cofactor is not clear considering that the reaction does not involve redox chemistry%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4570 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4570 ZOBELLIA_4571 ZOBELLIA_4571 ilvD1 ilvD1 5280758 5282434 - Dihydroxy-acid dehydratase Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine%2C the dehydratation of 2%2C3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid%3B Binds a 4Fe-4S cluster%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4571 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4571 ZOBELLIA_4572 ZOBELLIA_4572 ybgK ybgK 5282860 5283699 - Conserved hypothetical protein Protein that shows some similarities with the uncharacterized YbgK protein from Escherichia coli K12. YbgK and YbgJ Probably are involved in a common metabolism%3B Contains a Allophanate hydrolase subunit 2 domain%3B Localized in the cytoplasm gene gene4572 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4572 ZOBELLIA_4573 ZOBELLIA_4573 ybgJ ybgJ 5283692 5284429 - Conserved hypothetical protein Protein that shows some similarities with the uncharacterized YbgJ protein from Escherichia coli K12. YbgJ and YbgK Probably are involved in a common metabolism%3B Contains a Allophanate hydrolase subunit 1 domain%3B Localized in the cytoplasm gene gene4573 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4573 ZOBELLIA_4574 ZOBELLIA_4574 ZOBELLIA_4574 5284426 5285169 - LamB family protein Protein belonging to the LamB family (UPF0271). The exact molecular function of the proteins in this family is unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene4574 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4574 ZOBELLIA_4575 ZOBELLIA_4575 ZOBELLIA_4575 5285453 5285896 + Conserved hypothetical protein Localized in the cytoplasm gene gene4575 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4575 ZOBELLIA_4576 ZOBELLIA_4576 ZOBELLIA_4576 5285914 5286477 + Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4576 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4576 ZOBELLIA_4577 ZOBELLIA_4577 ZOBELLIA_4577 5287053 5287178 + Putative protein Hypothetical protein gene gene4577 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4577 ZOBELLIA_4578 ZOBELLIA_4578 ZOBELLIA_4578 5287340 5288047 - Mg chelatase family protein Protein displaying similarity with the C-terminal region of Mg chelatase subunit ChlI%3B Localized in the cytoplasm%3B~Function unclear gene gene4578 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4578 ZOBELLIA_4579 ZOBELLIA_4579 ZOBELLIA_4579 5288290 5288550 + Putative membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4579 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4579 ZOBELLIA_458 ZOBELLIA_458 ZOBELLIA_458 585914 589237 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (127-201)%2C and a Plug module (217-324) acting as the channel gate%3B The signal peptide is cleaved between the residue 29 and 30%3B~Family membership gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_458 ZOBELLIA_4580 ZOBELLIA_4580 ZOBELLIA_4580 5288556 5288819 + Putative protein Hypothetical protein gene gene4580 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4580 ZOBELLIA_4581 ZOBELLIA_4581 ZOBELLIA_4581 5289156 5290766 + Large serine recombinase Serine recombinases perform site-specific recombination of DNA molecules by a concerted%2C four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase%3B Contains an N-terminal catalytic and dimerization domain (with the conserved serine residue)%2C a central conserved domain usually associated with recombinases and a C-terminal helix-turn-helix DNA-binding domain%3B Belongs to the site-specific Serine recombinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4581 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4581 ZOBELLIA_4582 ZOBELLIA_4582 ZOBELLIA_4582 5290829 5291776 + Conserved hypothetical protein Localized in the cytoplasm gene gene4582 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4582 ZOBELLIA_4583 ZOBELLIA_4583 ZOBELLIA_4583 5291781 5292353 + PIN-like protein Proteins in the PIN domain family are Localized in the cytoplasm%3B~Function unclear gene gene4583 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4583 ZOBELLIA_4584 ZOBELLIA_4584 gepA gepA 5292596 5293087 + Genetic Element Protein A The Genetic Element Protein A is part of a Bacteriophage or a conjugative transposon. Its exact function is unknown%3B Localized in the cytoplasm%3B~Function unclear gene gene4584 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4584 ZOBELLIA_4585 ZOBELLIA_4585 ZOBELLIA_4585 5293093 5293425 + Hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4585 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4585 ZOBELLIA_4586 ZOBELLIA_4586 ZOBELLIA_4586 5293434 5293574 + Putative protein Hypothetical protein gene gene4586 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4586 ZOBELLIA_4587 ZOBELLIA_4587 ZOBELLIA_4587 5293984 5294196 + Putative membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4588 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4587 ZOBELLIA_4588 ZOBELLIA_4588 ZOBELLIA_4588 5293850 5293993 - Putative protein Hypothetical protein gene gene4587 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4588 ZOBELLIA_4589 ZOBELLIA_4589 ZOBELLIA_4589 5294389 5294526 + Putative protein Hypothetical protein gene gene4589 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4589 ZOBELLIA_459 ZOBELLIA_459 ZOBELLIA_459 589446 590609 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_459 ZOBELLIA_4590 ZOBELLIA_4590 tnpR tnpR 5294659 5295252 + Transposon resolvase Transposon resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products. It contains an N-terminal catalytic and dimerization domain that contains a conserved serine residue involved in the transient covalent attachment to DNA%2C and a C-terminal helix-turn-helix DNA-binding domain%3B Belongs to the site-specific Serine Recombinase family%2C Resolvase and Invertase subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4590 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4590 ZOBELLIA_4591 ZOBELLIA_4591 ZOBELLIA_4591 5295413 5295700 + Putative protein Hypothetical protein gene gene4591 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4591 ZOBELLIA_4592 ZOBELLIA_4592 ZOBELLIA_4592 5295700 5297166 + Poxvirus D5-like protein Protein containing a C-terminal Poxvirus D5 protein-like found at the C terminus of phage P4 alpha protein and related proteins. This domain could correspond the ori DNA recognition site%3B Localized in the cytoplasm%3B~Family membership gene gene4592 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4592 ZOBELLIA_4593 ZOBELLIA_4593 ZOBELLIA_4593 5297151 5298014 + Conserved hypothetical protein Localized in the cytoplasm gene gene4593 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4593 ZOBELLIA_4594 ZOBELLIA_4594 ZOBELLIA_4594 5298011 5298523 + Hypothetical protein Putatively localized in the cytoplasm gene gene4594 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4594 ZOBELLIA_4595 ZOBELLIA_4595 ZOBELLIA_4595 5298520 5299053 + Conserved hypothetical protein Localized in the cytoplasm gene gene4595 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4595 ZOBELLIA_4596 ZOBELLIA_4596 ZOBELLIA_4596 5299105 5299224 + Putative protein Hypothetical protein gene gene4596 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4596 ZOBELLIA_4597 ZOBELLIA_4597 ZOBELLIA_4597 5299221 5299487 - Conserved hypothetical protein Localized in the cytoplasm gene gene4597 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4597 ZOBELLIA_4598 ZOBELLIA_4598 ZOBELLIA_4598 5299523 5300233 - Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF159 family%3B Localized in the cytoplasm gene gene4598 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4598 ZOBELLIA_4599 ZOBELLIA_4599 comM comM 5300282 5301130 - Competence protein comM ComM is induced during competence development. Not needed for DNA uptake. May be involved in a recombination step%3B Belongs to the Mg-chelatase subunits D/I family%2C ComM subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4599 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4599 ZOBELLIA_46 ZOBELLIA_46 purB purB 46083 47426 + Adenylosuccinate lyase Adenylosuccinate lyase catalyzes step 8 in the pathway for de novo synthesis of IMP and also the final reaction in the two-step sequence from IMP to AMP. It cleaves succinylaminoimidazole carboxamide ribotide into aminoimidazole carboxamide ribotide and fumarate%2C as well as adenylosuccinate into adenylate and fumarate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_46 ZOBELLIA_460 ZOBELLIA_460 ZOBELLIA_460 590721 591323 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_460 ZOBELLIA_4600 ZOBELLIA_4600 quiP quiP 5301182 5303581 - Acyl-homoserine lactone acylase%2C family S45 Acyl-homoserine lactone acylase catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL)%2C releasing homoserine lactone (HSL) and the corresponding fatty acid%3B Belongs to the family 45 of the serine peptidases (45)%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene4600 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4600 ZOBELLIA_4601 ZOBELLIA_4601 dsbD dsbD 5304047 5306014 - Thiol:disulfide interchange protein DsbD%2C also known as protein-disulfide reductase%2C is required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps%3B Uses NAD(P) as cofactor%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4601 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4601 ZOBELLIA_4602 ZOBELLIA_4602 tilS tilS 5306011 5307318 - tRNA(Ile)-lysidine synthase TilS ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU%2C in an ATP-dependent manner. Cytidine is converted to lysidine%2C thus changing the amino acid specificity of the tRNA from methionine to isoleucine. The N-terminal region contains the highly conserved SGGXDS motif%2C predicted to be a P-loop motif involved in ATP binding%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4602 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4602 ZOBELLIA_4603 ZOBELLIA_4603 ZOBELLIA_4603 5307380 5308678 - Anthranilate synthase component I-like protein Enzyme that contains a C-terminal chorismate binding domain and belonging to the anthranilate synthase component I family%3B Localized in the cytoplasm%3B~Family membership gene gene4603 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4603 ZOBELLIA_4604 ZOBELLIA_4604 ZOBELLIA_4604 5309204 5309428 + Putative protein Hypothetical protein gene gene4605 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4604 ZOBELLIA_4605 ZOBELLIA_4605 ZOBELLIA_4605 5308689 5309222 - CAZ98740.1 Flavoprotein belonging to the NADPH-dependent FMN reductase family. Its specificity is unclear%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4604 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4605 ZOBELLIA_4606 ZOBELLIA_4606 ZOBELLIA_4606 5309444 5310628 + Conserved hypothetical membrane protein Contains eight transmembrane helice%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4606 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4606 ZOBELLIA_4607 ZOBELLIA_4607 pdhD pdhD 5310712 5312118 - Dihydrolipoyl dehydrogenase%2C E3 component The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2%2C linking glycolysis to the tricarboxylic acid cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). PdhD is the E3 component. It catalyzes the oxidation of dihydrolipoamide to lipoamide. PdhD is a homodimer which binds 1 NADP and 1 FAD per subunit%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4607 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4607 ZOBELLIA_4608 ZOBELLIA_4608 nhaC nhaC 5312250 5313728 + Na+/H+ antiporter NhaC NhaC is a Na+/H+ antiporter involved in pH homeostasis and sodium extrusion%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4608 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4608 ZOBELLIA_4609 ZOBELLIA_4609 ZOBELLIA_4609 5313978 5314622 + Peroxiredoxin Peroxiredoxins are thiol peroxidase involved in redox regulation of the cell. Can reduce H(2)O(2)%2C short chain organic%2C fatty acid%2C and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox-active cysteine called the peroxidatic cysteine. It oxidized the peroxide substrate to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4609 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4609 ZOBELLIA_461 ZOBELLIA_461 ZOBELLIA_461 592065 595595 - PKD repeats containing lipoprotein Contains C-terminal PKD repeats and a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_461 ZOBELLIA_4610 ZOBELLIA_4610 trxA trxA 5314727 5315041 + Thioredoxin Thioredoxin is a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4610 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4610 ZOBELLIA_4611 ZOBELLIA_4611 ZOBELLIA_4611 5315022 5315279 + Conserved hypothetical protein Localized in the cytoplasm. gene gene4611 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4611 ZOBELLIA_4612 ZOBELLIA_4612 tpx tpx 5315469 5315975 + Thiol peroxidase Thiol peroxidase has an antioxidant activity by removing peroxides or H(2)O(2). Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4612 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4612 ZOBELLIA_4613 ZOBELLIA_4613 dgkA dgkA 5315968 5316336 + Diacylglycerol kinase Diacylglycerol kinase recycles diacylglycerol produced during the turnover of membrane phospholipids. May play a role in adaptability to environmental stress conditions such as acid tolerance%2C elevated temperatures and high osmolarity. Features two transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4613 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4613 ZOBELLIA_4614 ZOBELLIA_4614 ZOBELLIA_4614 5316390 5318339 + Hypothetical membrane protein Protein that could belong to the alkaline phosphatase superfamily%3B Contains five N-terminal transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4614 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4614 ZOBELLIA_4615 ZOBELLIA_4615 ftsK ftsK 5318449 5320842 + DNA translocase FtsK FtsK is a DNA motor protein%2C which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it. It forms a hexamer. Features four transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4615 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4615 ZOBELLIA_4616 ZOBELLIA_4616 ZOBELLIA_4616 5320869 5321513 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4616 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4616 ZOBELLIA_4617 ZOBELLIA_4617 ZOBELLIA_4617 5321593 5323083 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Belongs to the predicted permease YjgP/YjgQ family%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4617 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4617 ZOBELLIA_4618 ZOBELLIA_4618 ribAB ribAB 5323080 5324222 + Riboflavin biosynthesis protein RibAB Riboflavin biosynthesis protein RibAB is a bifunctional enzyme with a N-terminal 3%2C4-dihydroxy-2-butanone 4-phosphate synthase domain and a C-terminal GTP cyclohydrolase II domain. The former enzymatic activity synthesized 3%2C4-Dihydroxy-2-butanone 4-phosphate from ribulose 5-phosphate and serves as the biosynthetic precursor for the xylene ring of riboflavin. GTP cyclohydrolase II catalyzes the first step in the biosynthesis of riboflavin. The enzyme converts GTP and water to formate%2C 2%2C5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine and pyrophosphate%2C and requires magnesium as a cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4618 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4618 ZOBELLIA_4619 ZOBELLIA_4619 ZOBELLIA_4619 5324242 5328276 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4619 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4619 ZOBELLIA_4620 ZOBELLIA_4620 manA manA 5328339 5330651 - Alpha-1%2C2-mannosidase%2C family GH92 Belongs to the family 92 of glycoside hydrolases (GH92)%3B Possibly involved in the mannane degradation or putatively involved in the glycoprotein biosynthesis%3B Signal peptide of lipoprotein cleaved between the residues 22 and 23%3B Putatively localized in the outer membrane%3B~High confidence in function and specificity gene gene4620 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4620 ZOBELLIA_4621 ZOBELLIA_4621 ZOBELLIA_4621 5330665 5332716 - Glycoside hydrolase%2C family GH115 Glycoside hydrolases hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety%3B Belongs to the family 115 of the glycoside hydrolases%3B Signal peptide cleaved between the residues 26 and 27%3B Putatively localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4621 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4621 ZOBELLIA_4622 ZOBELLIA_4622 ZOBELLIA_4622 5332814 5334475 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 23 and 24%3B Putatively localized in the outer membrane%3B~Family membership gene gene4622 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4622 ZOBELLIA_4623 ZOBELLIA_4623 ZOBELLIA_4623 5334494 5337568 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (23-97) and the Plug module (113-236) acting as a channel gate%3B The signal peptide is cleaved between the residues 21 and 22%3B~Family membership gene gene4623 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4623 ZOBELLIA_4624 ZOBELLIA_4624 ZOBELLIA_4624 5337947 5338732 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4624 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4624 ZOBELLIA_4625 ZOBELLIA_4625 ZOBELLIA_4625 5338821 5340011 - PLP-dependent aminotransferase Protein belonging to the DegT/DnrJ/EryC1/StrS aminotransferase family%2C which is included in the pyridoxal-phosphate (PLP)-dependent aminotransferase superfamily%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4625 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4625 ZOBELLIA_4626 ZOBELLIA_4626 nfnB3 nfnB3 5340053 5340691 - 6%2C7-dihydropteridine reductase Also called oxygen-insensitive NAD(P)H nitroreductase this enzyme reduces a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents%2C two electrons are transferred. Capable of reducing nitrofurazone%2C quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2%2C4-dinitrobenzamide)%3B Uses the FMN as cofactor%3B Belongs to the nitroreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4626 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4626 ZOBELLIA_4627 ZOBELLIA_4627 ZOBELLIA_4627 5340713 5340913 + Putative protein Hypothetical protein gene gene4627 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4627 ZOBELLIA_4628 ZOBELLIA_4628 ZOBELLIA_4628 5341040 5342335 + Amino acid transporter Conserved amino acid transporter. Its exact specificity is unknown. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene4628 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4628 ZOBELLIA_4629 ZOBELLIA_4629 ZOBELLIA_4629 5342436 5343092 + Conserved hypothetical protein Localized in the cytoplasm. gene gene4629 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4629 ZOBELLIA_4630 ZOBELLIA_4630 ZOBELLIA_4630 5343008 5343391 + Conserved hypothetical protein Localized in the cytoplasm. gene gene4630 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4630 ZOBELLIA_4631 ZOBELLIA_4631 ZOBELLIA_4631 5343496 5343618 + Putative protein Hypothetical protein gene gene4632 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4631 ZOBELLIA_4632 ZOBELLIA_4632 ZOBELLIA_4632 5343381 5343530 - Putative protein Hypothetical protein gene gene4631 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4632 ZOBELLIA_4633 ZOBELLIA_4633 ZOBELLIA_4633 5343996 5344637 - Two-component system-Response regulator Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA- binding activity (here%2C a LuxR-type HTH domain) that acts as transcriptional regulator%3B~Family membership gene gene4633 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4633 ZOBELLIA_4634 ZOBELLIA_4634 ZOBELLIA_4634 5345351 5347225 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 28 and 29%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4634 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4634 ZOBELLIA_4635 ZOBELLIA_4635 ZOBELLIA_4635 5347404 5348666 - OmpA-like outer membrane protein Protein belonging to the OmpA family. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Family membership gene gene4635 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4635 ZOBELLIA_4636 ZOBELLIA_4636 ZOBELLIA_4636 5348739 5348837 - Putative protein Hypothetical protein gene gene4636 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4636 ZOBELLIA_4637 ZOBELLIA_4637 gapB gapB 5349266 5350255 + Glyceraldehyde 3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1%2C3-diphospho-glycerate. Also it plays an important role in gluconeogenesis%3B Acts as an homotetramer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4637 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4637 ZOBELLIA_4638 ZOBELLIA_4638 mroA5 mroA5 5350384 5351478 + Aldose 1-epimerase Aldose 1-epimerase or Mutarotase is responsible for the anomeric interconversion of aldoses between their alpha- and beta-forms%3B It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose%3B Signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~High confidence in function and specificity gene gene4639 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4638 ZOBELLIA_4639 ZOBELLIA_4639 ZOBELLIA_4639 5350327 5350455 - Putative protein Hypothetical protein gene gene4638 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4639 ZOBELLIA_464 ZOBELLIA_464 yqfF yqfF 596783 598831 - Conserved hypothetical protein This protein is a putative receptor with a N-terminal extracellular domain%2C a central membrane domain and a C-terminal metal-dependent phosphohydrolase domain. Its exact function is unknown%3B Contains a N-terminal transmembrane helix and seven transmembrane helices in the central region%3B Localized in the cytoplamic membrane%3B~Function unclear gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_464 ZOBELLIA_4640 ZOBELLIA_4640 ZOBELLIA_4640 5351491 5352339 - NmrA family oxidoreductase Conserved protein belonging to the NmrA-type oxidoreductase family%2C but its exact function is unknown. NmrA is a negative transcriptional regulator involved in the control of nitrogen metabolite repression in various fungi. Its crystal structure has revealed an unexpected similarity to the short-chain dehydrogenase/reductase (SDR) family. NAD binds to NmrA in vitro. Localized in the cytoplasm.%3B~Family membership gene gene4640 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4640 ZOBELLIA_4641 ZOBELLIA_4641 ZOBELLIA_4641 5352361 5352558 - Putative protein Hypothetical protein gene gene4641 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4641 ZOBELLIA_4642 ZOBELLIA_4642 ZOBELLIA_4642 5352664 5353047 - Hypothetical membrane protein Contains an uncleavable signal sequence%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4642 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4642 ZOBELLIA_4643 ZOBELLIA_4643 ZOBELLIA_4643 5353145 5354005 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4643 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4643 ZOBELLIA_4644 ZOBELLIA_4644 ZOBELLIA_4644 5354203 5355327 - Fasciclin repeats protein Conserved protein containing two fascilin domains. These domains%2C also known as FAS1 or BIgH3 domains%2C are extracellular modules of about 140 amino acid residues. Each fascilin domain consists of seven-stranded wedge and at least five alpha helices%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%2C Localized in the outer membrane%3B~Family membership gene gene4644 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4644 ZOBELLIA_4645 ZOBELLIA_4645 ccpA3 ccpA3 5355437 5357284 - Di-heme cytochrome c peroxidase The Di-heme cytochrome c peroxidase reduces hydrogen peroxide to water using c-type heme as an oxidizable substrate. However%2C since it possesses two%2C instead of one%2C heme prosthetic groups%2C CcpA reduce hydrogen peroxide without the need to generate semi-stable free radicals%3B CcpA is structured into two domains%2C each containing one c-type heme group%2C with a calcium-binding site at the domain interface%3B Putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene4645 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4645 ZOBELLIA_4646 ZOBELLIA_4646 ZOBELLIA_4646 5357370 5358908 - Conserved hypothetical protein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Lcocalized in the outer membrane gene gene4646 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4646 ZOBELLIA_4647 ZOBELLIA_4647 gfoA gfoA 5359167 5360306 - Glucose-fructose oxidoreductase To protect the bacterium against osmotic shock%2C the periplasmic glucose-fructose oxidoreductase produces the compatible%2C solute sorbitol by reduction of fructose%2C coupled with the oxidation of glucose to gluconolactone. GfoA formes a homodimer and each subunit contains tightly associated NADP which is not released during the catalytic cycle. It belongs to the GFO/IDH/MOCA family and adopts a Rossmann fold. Features an uncleaved signal peptide. Localized in the periplasm.%3B~High confidence in function and specificity gene gene4647 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4647 ZOBELLIA_4648 ZOBELLIA_4648 ZOBELLIA_4648 5360474 5360725 + Putative membrane protein Contains a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4648 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4648 ZOBELLIA_4649 ZOBELLIA_4649 ZOBELLIA_4649 5360796 5361266 + Hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4649 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4649 ZOBELLIA_465 ZOBELLIA_465 thlA thlA 598952 600124 + Acetyl-CoA acetyltransferase Acetyl-CoA acetyltransferase is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or mevalonate biogenesis. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_465 ZOBELLIA_4650 ZOBELLIA_4650 ZOBELLIA_4650 5361280 5361966 + Acetylesterase%2C lipase-GDSL family Acetylesterase that belongs to the lipase-GDSL Pfam family%2C which includes families 3 and 12 of the carbohydrate esterases (CE3%2C CE12). The conserved catalytic residues are Ser54%2C Asp202 and His205. Features an uncleaved signal peptide.%3B~Specificity unclear gene gene4650 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4650 ZOBELLIA_4651 ZOBELLIA_4651 ZOBELLIA_4651 5362042 5363802 + Flavin containing amine oxidoreductase Flavin containing amine oxidoreductase which consists of a DAO (D-amino acid oxidase) domain%3B Use FAD as cofactor%3B Could be involved in the carotenoid biosynthesis%3B Belongs to the carotenoid/retinoid oxidoreductase family%3B Localized in the cytoplasm%3B~Function unclear gene gene4651 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4651 ZOBELLIA_4652 ZOBELLIA_4652 ZOBELLIA_4652 5363903 5364166 + Putative protein Hypothetical protein gene gene4652 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4652 ZOBELLIA_4653 ZOBELLIA_4653 dgoD dgoD 5364176 5365336 - Galactonate dehydratase Galactonate dehydratase is involved in the galactose metabolism. It converts the D-galactonate to 2-dehydro-3-deoxy-D-galactonate%3B Contains a N-terminal Enolase N-terminal domain-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase/muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4653 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4653 ZOBELLIA_4654 ZOBELLIA_4654 dgoT dgoT 5365368 5366669 - D-galactonate transporter Involved in the intake of galactonate into the cell%3B The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 11 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4654 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4654 ZOBELLIA_4655 ZOBELLIA_4655 bgaF bgaF 5366976 5369513 - Beta-galactosidase%2C family GH2 Enzyme belonging to the family 2 of glycoside hydrolases (GH2) which catalyzes the hydrolysis of the beta-1%2C4 linkage at the terminal non-reducing of beta-D-galactosides%2C releasing a beta-D-galactose residue%3B Signal peptide of lipoprotein cleaved between residues 17 and 18%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene4655 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4655 ZOBELLIA_4656 ZOBELLIA_4656 rhaT2 rhaT2 5369629 5370645 - L-rhamnose/proton symporter L-rhamnose/proton symporter is involved in the uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell. Can also transport L-mannose and L-xylose%2C but at reduced rates. Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4656 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4656 ZOBELLIA_4657 ZOBELLIA_4657 mroA6 mroA6 5370706 5371749 - Aldose 1-epimerase Aldose 1-epimerase or Mutarotase is responsible for the anomeric interconversion of aldoses between their alpha- and beta-forms%3B It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose%3B Localized in cytoplasm%3B~High confidence in function and specificity gene gene4657 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4657 ZOBELLIA_4658 ZOBELLIA_4658 ZOBELLIA_4658 5371787 5372881 - Galactonate dehydratase Galactonate dehydratase is involved in the galactose metabolism. It converts the D-galactonate to 2-dehydro-3-deoxy-D-galactonate%3B Contains a N-terminal domain with a Enolase N-terminal domain-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase / muconate lactonizing enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4658 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4658 ZOBELLIA_4659 ZOBELLIA_4659 aldA aldA 5372882 5374336 - Lactaldehyde dehydrogenase Lactaldehyde dehydrogenase is involved in the catabolism of L-fucose and L-rhamnose and is induced by these sugars. AldA catalyzes the NAD-dependent oxidation of lactaldehyde into lactate%3B Forms a tetramer%3B Belongs to the aldehyde dehydrogenase fold family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4659 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4659 ZOBELLIA_466 ZOBELLIA_466 ZOBELLIA_466 600149 600901 + Dipeptidyl peptidase%2C family C40 Dipeptidyl peptidase hydrolyzes gamma-D-Glu-L-(meso)A2pm linkages only in those peptide units that have a free N-terminal L-alanine. It is involved in peptidoglycan metabolism. Belongs to the family 40 of the cysteine peptidases. These peptidases contain single conserved cysteine and histidine residues that form a putative catalytic dyad in the order Cys%2C His. Features also a bacterial SH3 domain in the N-terminal region.%3B~High confidence in function and specificity gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_466 ZOBELLIA_4660 ZOBELLIA_4660 ZOBELLIA_4660 5374350 5375738 - Sulfatase%2C family S1-19 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 19%3B Signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Family membership gene gene4660 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4660 ZOBELLIA_4661 ZOBELLIA_4661 kduD1 kduD1 5375784 5376554 - 2-deoxy-D-gluconate-3-dehydrogenase Enzyme that belongs to the Pentose and glucuronate interconversions pathway%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4661 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4661 ZOBELLIA_4662 ZOBELLIA_4662 ZOBELLIA_4662 5376579 5377595 - Long chain dehydrogenase/reductase The long chain dehydrogenases/reductases are zinc-containing enzymes. Zinc-dependant enzymes are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit where one of the zinc atom is essential for catalytic activity while the other is not. The catalytic zinc is coordinated by two cysteines and one histidine%3B Contains a C-terminal domain having a classical Rossman-fold that reversibly binds NAD(H)%3B The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold%3B Localized in the cytoplasm%3B~Family membership gene gene4662 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4662 ZOBELLIA_4663 ZOBELLIA_4663 ZOBELLIA_4663 5377609 5378835 - Conserved hypothetical protein Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane gene gene4663 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4663 ZOBELLIA_4664 ZOBELLIA_4664 ZOBELLIA_4664 5378887 5379618 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4664 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4664 ZOBELLIA_4665 ZOBELLIA_4665 ZOBELLIA_4665 5379863 5380654 - IclR-type transcriptional regulator IclR-type transcriptional regulators display a Helix-Turn-Helix motif at the N-terminus. Localized in the cytoplasm.%3B~Specificity unclear gene gene4665 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4665 ZOBELLIA_4666 ZOBELLIA_4666 ZOBELLIA_4666 5380750 5382393 - Conserved hypothetical membrane protein Contains a N-terminal transmembrane segement followed by three tetratricopeptide repeats (TPR) and a C-terminal LuxR-type HTH domain. Between the TPR and HTH domains a second transmembrane segement is present%3B This Protein could interact with the DNA (transcriptional control or transcription factor)%3B Probably localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4666 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4666 ZOBELLIA_4667 ZOBELLIA_4667 ZOBELLIA_4667 5382397 5382642 - Hypothetical protein Sequence that displays some similarities with the C-terminal end of several paralogous proteins%3B Putatively localized in the cytoplasm gene gene4667 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4667 ZOBELLIA_4668 ZOBELLIA_4668 ZOBELLIA_4668 5383625 5385373 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Family membership gene gene4668 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4668 ZOBELLIA_4669 ZOBELLIA_4669 ZOBELLIA_4669 5385394 5388576 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (27-99) and the Plug module (115-218) acting as a channel gate%3B The signal peptide is cleaved between the residues 25 and 26%3B~Family membership gene gene4669 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4669 ZOBELLIA_467 ZOBELLIA_467 ZOBELLIA_467 601277 602539 - TPR repeats protein Conserved protein containing three tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Function unclear gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_467 ZOBELLIA_4670 ZOBELLIA_4670 ZOBELLIA_4670 5388816 5389040 - Putative protein Hypothetical protein gene gene4670 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4670 ZOBELLIA_4671 ZOBELLIA_4671 ZOBELLIA_4671 5389062 5389859 - IclR-type transcriptional regulator IclR-type transcriptional regulators display a Helix-Turn-Helix motif at the N-terminus. Localized in the cytoplasm.%3B~Specificity unclear gene gene4671 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4671 ZOBELLIA_4672 ZOBELLIA_4672 ZOBELLIA_4672 5390232 5391848 - Sulfatase%2C family S1-16 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 16%3B Putative lipoprotein signal peptide cleaved between the residue 18 and 19%3B Possibly localized in the outer membrane%3B~Family membership gene gene4672 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4672 ZOBELLIA_4673 ZOBELLIA_4673 ZOBELLIA_4673 5391955 5392746 - Carbohydrate esterase%2C family CE1 Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides%3B Belongs to the family 1 of the carbohydrate esterases (CE1)%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4673 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4673 ZOBELLIA_4674 ZOBELLIA_4674 adhI adhI 5392755 5393873 - Alcohol dehydrogenase class 3 / S-(hydroxymethyl)glutathione dehydrogenase Oxidizes long-chain aliphatic alcohols%2C long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols%3B Contains two zinc atoms. One is essential for catalytic activity while the other is not%3B Possibly involved in the metabolism of xenobiotics by cytochrome P450%3B Belongs to the zinc-containing alcohol dehydrogenase family%2C class- III subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4674 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4674 ZOBELLIA_4675 ZOBELLIA_4675 ZOBELLIA_4675 5393917 5395173 - Ferredoxin reductase The oxidation of substrat by a cytochrome P450 requires the participation of a flavoprotein such as ferredoxin reductase%2C and an iron-sulfur protein such as ferredoxin%2C to mediate the transfer of electrons from NADH to P450 for oxygen activation%3B Uses the FAD as cofactor%3B Belongs to the FAD-dependent oxidoreductase family%2C ferredoxin-NADP reductase sub-family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4675 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4675 ZOBELLIA_4676 ZOBELLIA_4676 fdxA3 fdxA3 5395181 5395489 - 2Fe-2S ferredoxin Ferredoxins are electron carrier proteins with an iron-sulfur as cofactor and that transfer electrons in a wide variety of metabolic reactions. Belongs to the putidaredoxin%2C terpredoxin and adrenodoxin sub-family and uses 2Fe-2S cluster as cofactor ligated at four conserved cysteine residues. The general core structure consists of beta(2)-alpha-beta(2). Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4676 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4676 ZOBELLIA_4677 ZOBELLIA_4677 cypA cypA 5395494 5396657 - Cytochrome P450 Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds%2C including steroids%2C fatty acids%2C and xenobiotics%3B P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains%2C called P450-containing monooxygenase systems%3B Acts with the ferredoxin and the ferredoxin reductase%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4677 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4677 ZOBELLIA_4678 ZOBELLIA_4678 ZOBELLIA_4678 5396843 5397682 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4678 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4678 ZOBELLIA_4679 ZOBELLIA_4679 fucA9 fucA9 5397855 5399396 + Alpha-L-fucosidase%2C family GH29 The alpha-L-fucosidase is responsible for hydrolyzing of alpha-1%2C6-linked fucose joined to an alpha-L-fucoside%3B Belongs to the family 29 of glycoside hydrolases (GH29)%3B Signal peptide of lipoprotein cleaved between the residue 16 and 17%3B Probably localized in the outer membrane%3B~High confidence in function and specificity gene gene4679 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4679 ZOBELLIA_468 ZOBELLIA_468 gyrA gyrA 602583 605123 - DNA gyrase%2C subunit A DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings. It is a A2B2 heterotetramer. The A subunit being responsible for DNA breakage and rejoining%2C the B chain catalyzing ATP hydrolysis%3B Belongs to the type-II topoisomerase family%2C IIA subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_468 ZOBELLIA_4680 ZOBELLIA_4680 ZOBELLIA_4680 5399573 5400589 + Long chain dehydrogenase/reductase The long chain dehydrogenases/reductases are zinc-containing enzymes. Zinc-dependant enzymes are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit where one of the zinc atom is essential for catalytic activity while the other is not. The catalytic zinc is coordinated by two cysteines and one histidine%3B Contains a C-terminal domain having a classical Rossman-fold that reversibly binds NAD(H)%3B The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold%3B Localized in the cytoplasm%3B~Family membership gene gene4680 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4680 ZOBELLIA_4681 ZOBELLIA_4681 uxaA uxaA 5400627 5402279 + Altronate hydrolase Altronate hydrolase or Altronic acid hydratase converts the altronic acid to 2-keto-2-deoxygluconate%3B it is catalytically inactive in the absence of Fe2+%2C Mn2+%2C and beta-mercaptoethanol. Synergistic activation of enzyme is seen in the presence of both iron and manganese ions%2C suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre%3B Contains an N-terminal SAF domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4681 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4681 ZOBELLIA_4682 ZOBELLIA_4682 uxaB uxaB 5402318 5403766 + Altronate oxidoreductase Altronate oxidoreductase or Tagaturonate reductase catalyzes the NAD-dependent reduction of altronate into tagaturonate%3B Belongs to the Long-chain mannitol dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4682 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4682 ZOBELLIA_4683 ZOBELLIA_4683 ZOBELLIA_4683 5403794 5404621 + Amidohydrolase 2 family protein Belongs to the metal-dependent hydrolase superfamily%2C Amidohydrolase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene4683 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4683 ZOBELLIA_4684 ZOBELLIA_4684 ZOBELLIA_4684 5404710 5405504 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene4684 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4684 ZOBELLIA_4685 ZOBELLIA_4685 fucP2 fucP2 5405529 5406872 + L-fucose-proton symporter FucP mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose%2C but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene4685 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4685 ZOBELLIA_4686 ZOBELLIA_4686 ZOBELLIA_4686 5406874 5407215 + conserved hypothetical protein Protein belonging to the DUF718 family%2C which includes the rhamnose mutarotase YiiL from Escherichia coli%3B Localized in the cytoplasm gene gene4686 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4686 ZOBELLIA_4687 ZOBELLIA_4687 mdsA7 mdsA7 5407314 5408993 - Mucin-desulfating sulfatase%2C family S1-11 Mucin-desulfating sulfatases hydrolyse the sulfate groups from oligosaccharides present in mucins (heavily glycosylated proteins). In the mucins%2C the main sulfated sugars are N-acetyl-D-glucosamine-6-sulfate%2C galactose-6-sulfate and galactose-3-sulfate%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 11%3B Putative lipoprotein with a signal peptide cleaved between the residues 20 and 21%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene4687 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4687 ZOBELLIA_4688 ZOBELLIA_4688 ZOBELLIA_4688 5409148 5410251 - Beta-propeller fold protein This protein likely adopts a beta-propeller fold. Features a twin-arginine signal peptide. Localized in the periplasm.%3B~Family membership gene gene4688 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4688 ZOBELLIA_4689 ZOBELLIA_4689 ZOBELLIA_4689 5410313 5411830 - Conserved hypothetical protein Conserved hypothetical protein (family DUF1501). Belongs to the alkaline-phosphatase clan. Features a twin-arginine signal peptide. Localized in the periplasm. gene gene4689 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4689 ZOBELLIA_469 ZOBELLIA_469 clpC clpC 605383 607929 + Chaperone ClpC ClpC may interact with a clpP-like protease involved in degradation of denatured proteins and could be required for cell growth at high temperature%3B Contains 2 Clp amino terminal domains that function as a substrate-discriminating domain%2C 2 AAA ATPase domains and 1 UVR domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_469 ZOBELLIA_4690 ZOBELLIA_4690 ZOBELLIA_4690 5411857 5415105 - Conserved cytochrome c-containing protein This protein has a modular architecture composed of a N-terminal cytochrome C%2C a domain of unknown function (DUF1549) which includes a second cytochrome C%2C a central domain adopting a jelly roll fold (concavalin A-like) and a C-terminal DUF1553 domain. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes. The two domains DUF1549 and DUF1553 are usually found in Planctomycetes%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic and/or outer membrane%3B~Function unclear gene gene4690 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4690 ZOBELLIA_4691 ZOBELLIA_4691 ZOBELLIA_4691 5415163 5415270 + Putative protein Hypothetical protein gene gene4691 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4691 ZOBELLIA_4692 ZOBELLIA_4692 ZOBELLIA_4692 5415337 5416200 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene4692 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4692 ZOBELLIA_4693 ZOBELLIA_4693 ZOBELLIA_4693 5416204 5417526 - NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase. Belongs to the Rossmann fold family. Contains a twin-arginine translocation signal peptide%3B Localized in the periplasmic space%3B~Specificity unclear gene gene4693 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4693 ZOBELLIA_4694 ZOBELLIA_4694 ZOBELLIA_4694 5417523 5419352 - Sulfatase%2C family S1-17 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 17%3B Lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the cytoplasmic membrane or/and outer membrane%3B~Family membership gene gene4694 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4694 ZOBELLIA_4695 ZOBELLIA_4695 ZOBELLIA_4695 5419363 5423583 - One-component system sensor protein The sensor proteins consist of a sensing beta-propeller fold periplasmic domain%2C variable in sequence%2C reflective of the many different environmental signals%2C and of a cytoplasmic part composed of a histidine kinase domain%2C a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain)%3B Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4695 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4695 ZOBELLIA_4696 ZOBELLIA_4696 ZOBELLIA_4696 5423767 5427111 - Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins. The FG-GAP repeat has been predicted to fold into a beta propeller structure. The FG- GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B Contains a signal peptide uncleavable (residues 5 to 23) that would localize the protein in the cytoplsmic membrane (PSORT result)%3B~Function unclear gene gene4696 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4696 ZOBELLIA_4697 ZOBELLIA_4697 ZOBELLIA_4697 5427131 5430481 - Similar to ASPIC and UnbV protein containing FG-GAP repeats ASPIC and UnbV sequences are found associated with tetratrico peptide repeat in several paralogous proteins in Rhodopirellula baltica and with FG-GAP repeats in several eukaryotic integrin-like proteins and in several other bacterial proteins. The FG-GAP repeat has been predicted to fold into a beta propeller structure. The FG- GAP repeats are found in the N terminus of integrin alpha chains%2C a region that has been shown to be important for ligand binding%3B Contains a signal peptide of lipoprotein cleaved between the residues 23 and 24%3B Protein putatively localized in the outer membrane%3B~Function unclear gene gene4697 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4697 ZOBELLIA_4698 ZOBELLIA_4698 ZOBELLIA_4698 5430623 5432101 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Family membership gene gene4698 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4698 ZOBELLIA_4699 ZOBELLIA_4699 ZOBELLIA_4699 5432106 5435219 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (34-107) and the Plug module (123-228) acting as a channel gate%3B The signal peptide is cleaved between the residues 27 and 28%3B~Family membership gene gene4699 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4699 ZOBELLIA_47 ZOBELLIA_47 ZOBELLIA_47 47508 48323 - Small-conductance mechanosensitive channel Mechanosensitive channels provide protection against hypo-osmotic shock%2C responding both to stretching of the cell membrane and to membrane depolarisation%3B Contains three transmembrane helices%3B Belongs to the small-conductance MS channels%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_47 ZOBELLIA_470 ZOBELLIA_470 ZOBELLIA_470 608132 608533 + Conserved hypothetical protein Localized in the cytoplasm. gene gene470 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_470 ZOBELLIA_4700 ZOBELLIA_4700 ZOBELLIA_4700 5435583 5436398 + Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Possible signal peptide cleaved between the residues 30 and 31%3B Putatively localized in the periplasmic space%3B~Family membership gene gene4700 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4700 ZOBELLIA_4701 ZOBELLIA_4701 uxuA2 uxuA2 5436466 5437668 + Mannonate dehydratase Mannonate dehydratase%2C induced By fructuronate%2C is a Fe2+-requiring enzyme that plays a role in D-glucuronate catabolism%3B Mannonate dehydratase converts D-mannonate to 2-dehydro-3-deoxy-D-gluconate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4701 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4701 ZOBELLIA_4702 ZOBELLIA_4702 eda eda 5437672 5438340 - KHG/KDPG aldolase KHG/KDPG aldolase is a bifunctional enzyme catalyzing the interconversion of 4-hydroxy-2-oxoglutarate into pyruvate and glyoxylate (4-Hydroxy-2-oxoglutarate aldolase activity) and the interconversion of 6-phospho-2-dehydro-3-deoxy-D-gluconate into pyruvate and glyceraldehyde 3-phosphate (Phospho-2-dehydro-3-deoxygluconate aldolase activity). This enzyme is involved in the Entner-Doudoroff pathway and in the glyoxylate and dicarboxylate metabolism%3B Belongs to the class I aldolase whose catalytic mechanism involves the formation of a Schiff-base intermediate between the substrate and the epsilon-amino group of a lysine residue%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4702 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4702 ZOBELLIA_4703 ZOBELLIA_4703 kdgK2 kdgK2 5438365 5439405 - 2-dehydro-3-deoxygluconokinase The 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP)in the Entner-Doudoroff Pathway. KDG is the common intermediate product%2C that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers%2C like pectin and xylan as carbon sources%3B Belongs to the Carbohydrate kinase%2C PfkB family%2C 2-dehydro-3-deoxygluconokinase (KdgK) subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4703 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4703 ZOBELLIA_4704 ZOBELLIA_4704 ZOBELLIA_4704 5439555 5439650 + Putative protein Hypothetical protein gene gene4704 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4704 ZOBELLIA_4705 ZOBELLIA_4705 ZOBELLIA_4705 5439695 5440402 + Conserved hypothetical membrane protein Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4705 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4705 ZOBELLIA_4706 ZOBELLIA_4706 ZOBELLIA_4706 5440409 5440930 + Conserved hypothetical protein Localized in the cytoplasm gene gene4706 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4706 ZOBELLIA_4707 ZOBELLIA_4707 ZOBELLIA_4707 5440968 5441894 - Conserved hypothetical membrane protein Signal peptide cleaved between the residues 20 and 21%3B Putatively localized in the outer membrane%3B~Conserved hypothetical protein gene gene4707 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4707 ZOBELLIA_4708 ZOBELLIA_4708 dnaK dnaK 5442109 5444016 - Molecular chaperone DnaK DnaK is an molecular chaperones that couples cycles of ATP binding%2C hydrolysis%2C and ADP release by an N-terminal ATP-hydrolysing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. Acts in association with the co-chaperones GrpE (stimulates the rate of ADP release) and DnaJ (stimulates the ATPase activity%3B Protein induced By stress conditions e.g. heat shock%3B Belongs to the heat shock protein 70 (hsp70) family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4708 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4708 ZOBELLIA_4709 ZOBELLIA_4709 sdaA2 sdaA2 5444336 5445763 + L-serine dehydratase L-serine dehydratase is involved in the gluconeogenesis pathway. It catalyzes the deamination of serine to form pyruvate. It is activated by a post-translational modification via a system involving at least three gene products. There is considerable evidence for a free-radical activation mechanism%3B Binds a 4Fe-4S cluster as a cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4709 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4709 ZOBELLIA_471 ZOBELLIA_471 ZOBELLIA_471 608609 610162 - Conserved hypothetical protein Conserved modular protein Localized in the cytoplasm gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_471 ZOBELLIA_4710 ZOBELLIA_4710 ZOBELLIA_4710 5445832 5446395 + Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene4710 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4710 ZOBELLIA_4711 ZOBELLIA_4711 sugE sugE 5446468 5446794 + Quaternary ammonium compound-resistance protein sugE SugE is a quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium%2C cetyldimethylethyl ammonium and cetrimide cations. Unlike the other members of the small multidrug resistance (SMR) protein family%2C sugE exhibits a narrow specificity for a very specific class of compounds%3B Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene4711 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4711 ZOBELLIA_4712 ZOBELLIA_4712 ZOBELLIA_4712 5446952 5447737 + Conserved hypothetical protein Localized in the cytoplasm gene gene4712 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4712 ZOBELLIA_4713 ZOBELLIA_4713 ZOBELLIA_4713 5447829 5448626 + DNA/RNA non-specific endonuclease Endonuclease acting on both DNA and RNA. Cleaves double-stranded and single-stranded nucleic acids and requires. A catalytic histidine is located in a conserved region which also contains an aspartate that could be implicated in the binding of the divalent ion%3B Uses a divalent ion such as magnesium as cofactor%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4713 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4713 ZOBELLIA_4714 ZOBELLIA_4714 ZOBELLIA_4714 5448688 5449629 - Conserved hypothetical periplasmic protein Protein belonging to the DUF1080 family%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene4714 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4714 ZOBELLIA_4715 ZOBELLIA_4715 ZOBELLIA_4715 5449794 5451260 + NAD(P)-dependent dehydrogenase NAD(P)-dependent dehydrogenase%3B Belongs to the Rossmann fold family%3B Contains a twin-arginine translocation signal peptide%3B Localized in the periplasmic space%3B~Specificity unclear gene gene4715 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4715 ZOBELLIA_4716 ZOBELLIA_4716 ZOBELLIA_4716 5451323 5451781 - Conserved hypothetical periplasmic protein Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4716 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4716 ZOBELLIA_4717 ZOBELLIA_4717 panB panB 5451932 5452750 + 3-Methyl-2-oxobutanoate hydroxymethyltransferase 3-Methyl-2-oxobutanoate hydroxymethyltransferase catalyzes the first step in the biosynthesis of pantothenate (vitamin B5)%2C the precursor of coenzyme A and of the acyl carrier protein cofactor. The hydroxymethyl group from 5%2C10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate%3B Forms a Homodecamer (pentamer of dimers)%3B Binds 1 magnesium ion per subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4717 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4717 ZOBELLIA_4718 ZOBELLIA_4718 truC truC 5452807 5453505 + tRNA pseudouridine synthase C Enzyme responsible for synthesis of pseudouridine from uracil at position 65 in transfert RNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Belongs to the pseudouridine synthase RluA family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene4718 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4718 ZOBELLIA_4719 ZOBELLIA_4719 ZOBELLIA_4719 5453539 5454084 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4719 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4719 ZOBELLIA_472 ZOBELLIA_472 thrA thrA 610540 612984 + Aspartate kinase I / Homoserine dehydrogenase I ThrA is a fusion-protein between aspartate kinase I (N-terminal) and homoserine dehydrogenase I (C-terminal) involved in L-Lysine and L-threonine biosynthesis pathways. Aspartate kinase I converts L-aspartate to 4-phospho-L-aspartate and belongs to the amino acid kinase family. Homoserine dehydrogenase I converts the L-homoserine to L-aspartate 4-semialdehyde. Homoserine dehydrogenase I is composed of a substrate-binding domain belonging to Homoserine dehydrogenase family and a NAD-binding domain (Rossman fold). ThrA features also two central regulatory ACT domains%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_472 ZOBELLIA_4720 ZOBELLIA_4720 snr1 snr1 5454204 5455691 - Cytochrome c Snr1 Cytochrome c Snr1 is required for Nitrate Reduction. In the C-type cytochromes%2C the heme group is covalently attached by thioether bonds to two conserved cysteine residues (Cys-x-x-Cys-His). The conserved histidine residue is one of the two axial ligands of the heme iron. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes%3B contains a N-terminal domain of unknown function and a C-terminal cytochrome C domain%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasm.%3B~High confidence in function and specificity gene gene4720 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4720 ZOBELLIA_4721 ZOBELLIA_4721 ZOBELLIA_4721 5455990 5456799 - Conserved hypothetical membrane protein Integral membrane protein belonging to the DUF6 family%3B Contains nine transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4721 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4721 ZOBELLIA_4722 ZOBELLIA_4722 ZOBELLIA_4722 5456857 5458401 - Conserved hypothetical protein Localized in the cytoplasm gene gene4722 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4722 ZOBELLIA_4723 ZOBELLIA_4723 leuA2 leuA2 5458674 5459846 + 2-Isopropylmalate synthase 2-Isopropylmalate synthase catalyzes the first step in the L-leucine biosynthesis pathway. LeuA condensates the acetyl group of acetyl-CoA with 3-methyl-2- oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). LeuA2 is a paralogue of leuA1 which misses the C-terminal LeuA-dimerization domain. Localized in the cytoplasm.%3B~Specificity unclear gene gene4723 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4723 ZOBELLIA_4724 ZOBELLIA_4724 LeuB2 LeuB2 5459983 5461101 + 3-Isopropylmalate dehydrogenase 3-Isopropylmalate dehydrogenase catalyzes the third step in the L-leucine biosynthesis pathway. LeuB catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. LeuB forms a homodimer and binds one NAD+ and one Mg2+ or Mn2+ ion by subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4724 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4724 ZOBELLIA_4725 ZOBELLIA_4725 ZOBELLIA_4725 5461108 5462328 - Thiol-disulfide oxidoreductase Protein containing a N-terminal domain of unknown function and a C-terminal thiol-disulfide oxidoreductase domain belonging to the thioredoxin family. Thiol-disulfide oxidoreductase catalyzes the formation of disulfide bond in various substrates. Its exact specificity is not known%3B Putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene4725 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4725 ZOBELLIA_4726 ZOBELLIA_4726 pheT pheT 5462459 5464888 + Phenylalanyl-tRNA synthetase beta chain Phenylalanyl-tRNA synthetase catalyzes the attachment of phenylalanyl to its cognate transfer RNA molecule in a highly specific two-step reaction. It is an alpha2/beta2 tetramer composed of 2 subunits that belongs to class II aminoacyl-tRNA synthetases. PheT codes the beta subunit and folds as an anti-parallel beta-sheet flanked by alpha-helices. Phenylalanyl-tRNA synthetase binds 2 magnesium ions per tetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4726 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4726 ZOBELLIA_4727 ZOBELLIA_4727 ZOBELLIA_4727 5464944 5465498 - Fasciclin family protein In Eukaryotes%2C fascilin module containing proteins mediate cell adhesion throught an interaction with alpha3/beta1 integrin%3B This module%2C also known as FAS1 or BIgH3 domain%2C is an extracellular module of about 140 amino acid residues%3B Contains one only copy of fascilin module%3B Signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasm.%3B~Family membership gene gene4727 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4727 ZOBELLIA_4728 ZOBELLIA_4728 ZOBELLIA_4728 5465694 5466413 + Conserved hypothetical membrane protein Contains two C-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4728 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4728 ZOBELLIA_4729 ZOBELLIA_4729 ZOBELLIA_4729 5466494 5467642 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4729 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4729 ZOBELLIA_473 ZOBELLIA_473 thrB thrB 612987 613910 + Homoserine kinase Homoserine kinase is involved in the threonine biosynthesis pathway. It converts%2C in presence of ATP%2C the L-homoserine to O-phospho-L-homoserine. Belongs to the GHMP kinases family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_473 ZOBELLIA_4730 ZOBELLIA_4730 ZOBELLIA_4730 5467786 5469414 - ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Contains a duplicated ATPase domain%3B Belongs to the ABC transporter family%2C EF3 subfamily%3B Localized in the cytoplasm near of the cytoplasmic membrane by association with a membrane permease component%3B~Family membership gene gene4730 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4730 ZOBELLIA_4731 ZOBELLIA_4731 ZOBELLIA_4731 5469595 5470977 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene4731 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4731 ZOBELLIA_4732 ZOBELLIA_4732 talA2 talA2 5471061 5471714 - Transaldolase Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. It catalyzes the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme%2C together with transketolase%2C provides a link between the Embden-Meyerhof pathway and the non-oxidative phase of pentose-phosphate pathway%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4732 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4732 ZOBELLIA_4733 ZOBELLIA_4733 ZOBELLIA_4733 5471790 5472599 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene4733 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4733 ZOBELLIA_4734 ZOBELLIA_4734 ZOBELLIA_4734 5472950 5474002 + Glutamine cyclotransferase Glutamine cyclotransferase catalyzes the cyclization of free L-glutamine and N-terminal glutaminyl residues in proteins to pyroglutamate (5-oxoproline) and pyroglutamyl residues respectively. It belongs to a family conserved in plants and bacteria%2C but unrelated to the mammalian enzymes. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4734 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4734 ZOBELLIA_4735 ZOBELLIA_4735 ZOBELLIA_4735 5474003 5474404 + Thioesterase family protein Conserved protein belonging to the acyl-CoA thioester hydrolase family. Its exact function is unknown. Localized in the cytoplasm.%3B~Family membership gene gene4735 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4735 ZOBELLIA_4736 ZOBELLIA_4736 ZOBELLIA_4736 5474451 5476013 + Conserved beta helix fold protein Possible lipoprotein that consists of a pectin lyase like domain suggesting a beta helix fold for this protein%3B Signal peptide cleaved between the residues 25 and 26%3B probably localized in the outer membrane%3B~Conserved hypothetical protein gene gene4736 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4736 ZOBELLIA_4737 ZOBELLIA_4737 ZOBELLIA_4737 5476133 5476282 - Putative membrane protein Contains two transmembrane segments%3B Possibly localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4737 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4737 ZOBELLIA_4738 ZOBELLIA_4738 ZOBELLIA_4738 5476310 5477041 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C which acts as transcriptional regulator%3B~Family membership gene gene4738 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4738 ZOBELLIA_4739 ZOBELLIA_4739 ZOBELLIA_4739 5477423 5479522 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Lipoprotein signal peptide cleaved between the residues 26 and 27%3B Contains four N-terminal tetratrico peptide repeats (TPR) and one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4739 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4739 ZOBELLIA_474 ZOBELLIA_474 thrC thrC 613910 615205 + Threonine synthase Threonine synthase is involved in the threonine biosynthesis pathway. It converts the O-phospho-L-homoserine to L-threonine. Belongs to the Pyridoxal-phosphate dependent enzyme family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_474 ZOBELLIA_4740 ZOBELLIA_4740 ZOBELLIA_4740 5479547 5480218 + Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LuxR-type HTH domain%2C which acts as transcriptional regulator%3B~Family membership gene gene4740 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4740 ZOBELLIA_4741 ZOBELLIA_4741 ZOBELLIA_4741 5480384 5481040 + Hypothetical protein Probably a cytoplasmic protein gene gene4741 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4741 ZOBELLIA_4742 ZOBELLIA_4742 glyA glyA 5481171 5482445 - Serine hydroxymethyltransferase Serine hydroxymethyltransferase is involved in glycine and serine metabolism. It carries out interconversion of L-serine and glycine using pyridoxal phosphate (PLP) as cofactor. It catalyses the transfer of a hydroxymethyl group from N5%2C N10- methylene tetrahydrofolate to glycine%2C resulting in the formation of serine and tetrahydrofolate. It forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4742 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4742 ZOBELLIA_4743 ZOBELLIA_4743 fahA fahA 5482557 5483849 + Fumarylacetoacetase Fumarylacetoacetase catalyses the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield fumarate and acetoacetate as the final step in phenylalanine and tyrosine degradation. The products then join the citric acid cycle. It forms homodimer and binds one calcium ion and one magnesium ion as cofactors per subunit%3B Localized in the cytoplasm%3B~Hypothetical protein gene gene4743 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4743 ZOBELLIA_4744 ZOBELLIA_4744 ZOBELLIA_4744 5483907 5484116 - Conserved hypothetical protein Localized in the cytoplasm. gene gene4744 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4744 ZOBELLIA_4745 ZOBELLIA_4745 clpB1 clpB1 5484469 5487069 + Chaperone ClpB ClpB is a homohexamer that is a part of a stress-induced multi-chaperone system involved in the recovery of the cell from heat-induced damage%2C in cooperation with dnaK%2C dnaJ and grpE. Protein binding stimulates the ATPase activity%3B ATP hydrolysis unfolds the denatured protein aggregates contributing to the solubilization and refolding of denatured protein aggregates by dnaK%3B Contains 2 Clp amino terminal domains that function as a substrate-discriminating domain and 2 AAA ATPase domains%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4745 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4745 ZOBELLIA_4746 ZOBELLIA_4746 ZOBELLIA_4746 5487192 5487788 + TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene4746 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4746 ZOBELLIA_4747 ZOBELLIA_4747 ZOBELLIA_4747 5487883 5489607 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4747 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4747 ZOBELLIA_4748 ZOBELLIA_4748 ZOBELLIA_4748 5489707 5490264 + Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4748 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4748 ZOBELLIA_4749 ZOBELLIA_4749 smpB smpB 5490378 5490842 + SsrA-binding protein SmpB binds specifically to the ssrA RNA and is required for stable association of ssrA with ribosomes. SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the addition of a short peptide tag to the C-terminus of the partially synthesized nascent polypeptide chain. The SsrA- tagged protein is then degraded by C-terminal-specific proteases. Formation of an SmpB-SsrA complex appears to be critical in mediating SsrA activity after aminoacylation with alanine but prior to the transpeptidation reaction that couples this alanine to the nascent chain. localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4749 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4749 ZOBELLIA_475 ZOBELLIA_475 pepP1 pepP1 615242 616891 - Xaa-Pro aminopeptidase%2C family M24 Xaa-Pro aminopeptidase catalyzes the release of any N-terminal amino acid%2C including proline%2C that is linked to proline%2C even from a dipeptide or tripeptide. Belongs to the family M24 of the metallopeptidases. PepP requires two co-catalytic ions of manganese. Features a signal peptide cleaved between the residues 31 and 32. Localized in the periplasm.%3B~High confidence in function and specificity gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_475 ZOBELLIA_4750 ZOBELLIA_4750 pcm pcm 5490855 5491469 - Protein-L-isoaspartate O-methyltransferase Protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L- asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues. It uses S-adenosyl-L-methionine as a methyl donor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4750 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4750 ZOBELLIA_4751 ZOBELLIA_4751 ZOBELLIA_4751 5491659 5492618 + NAD(P)-dependent oxidoreductase NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family. Adopts a Rossmann fold. Localized in the cytoplasm.%3B~Specificity unclear gene gene4751 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4751 ZOBELLIA_4752 ZOBELLIA_4752 hbdA hbdA 5492638 5493528 + 3-Hydroxybutyryl-CoA dehydrogenase The 3-Hydroxybutyryl-CoA dehydrogenase is involved in butyrate/butanol-producing pathway. It converts the (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA%3B Belongs to the 3-hydroxyacyl-CoA dehydrogenase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4752 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4752 ZOBELLIA_4753 ZOBELLIA_4753 ZOBELLIA_4753 5493580 5494233 + Alpha/beta barrel fold protein Conserved protein displaying similarity with the N-terminal domain of Alanine racemase which folds as a alpha/beta barrel (TIM barrel fold). Localized in cytoplasm.%3B~Conserved hypothetical protein gene gene4753 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4753 ZOBELLIA_4754 ZOBELLIA_4754 ZOBELLIA_4754 5494287 5495657 + Nuclease Contains a N-terminal exonuclease domain found in ribonuclease T and the epsilon subunit of DNA polymerase III and%2C in the middle part%2C a GIY-YIG catalytic domain Localized in the cytoplasm%3B~Function unclear gene gene4754 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4754 ZOBELLIA_4755 ZOBELLIA_4755 ZOBELLIA_4755 5495660 5496508 + Ion channel Conserved ion channel belonging to the sodium%2C Potassium%2C Calcium ion channel family. Its specificity is unknown. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene4755 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4755 ZOBELLIA_4756 ZOBELLIA_4756 miaA miaA 5496508 5497440 + tRNA isopentenyltransferase tRNA isopentenyltransferase catalyzes the first step in the biosynthesis of 2-methylthio-N6-(delta(2)-isopentenyl)-adenosine adjacent to the anticodon of several tRNA species. It catalyzes the reaction: Isopentenyl diphosphate + tRNA %3D diphosphate + tRNA containing 6-isopentenyladenosine. It forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4756 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4756 ZOBELLIA_4757 ZOBELLIA_4757 gntK2 gntK2 5497430 5497942 + Gluconokinase Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate%3B GntK adopts an alpha/beta fold%2C consisting of a central sheet of five parallel beta-strands flanked by alpha-helices%3B Belongs to the shikimate kinase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4757 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4757 ZOBELLIA_4758 ZOBELLIA_4758 ZOBELLIA_4758 5497983 5498693 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity (here%2C a winged-helix DNA-binding domain) that acts as transcriptional regulator%3B~Hypothetical protein gene gene4758 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4758 ZOBELLIA_4759 ZOBELLIA_4759 ZOBELLIA_4759 5498705 5500285 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene4759 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4759 ZOBELLIA_476 ZOBELLIA_476 gcvT gcvT 617001 618086 + Glycine cleavage system T protein The glycine cleavage system is composed of four proteins: P%2C T%2C L and H. The T protein is the aminomethyltransferase. It catalyzes the reaction: [Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate %3D [protein]-dihydrolipoyllysine + 5%2C10-methylenetetrahydrofolate + NH3. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_476 ZOBELLIA_4760 ZOBELLIA_4760 coaE coaE 5500369 5500959 - Dephospho-CoA kinase Dephospho-CoA kinase catalyzes the final step in CoA biosynthesis%2C the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. It consists of three domains: the nucleotide-binding domain with a five-stranded parallel beta-sheet%2C the substrate- binding alpha-helical domain%2C and the lid domain formed by a pair of alpha-helices. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4760 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4760 ZOBELLIA_4761 ZOBELLIA_4761 ZOBELLIA_4761 5500956 5501867 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4761 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4761 ZOBELLIA_4762 ZOBELLIA_4762 ZOBELLIA_4762 5501925 5502926 - Glycosyltransferase%2C family GT2 Glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules%2C forming glycosidic bonds. This enzyme belongs to the family 2 of the glycosyltransferases. Features two transmembrane helices in C-terminus. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene4762 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4762 ZOBELLIA_4763 ZOBELLIA_4763 fabI fabI 5503053 5503865 - Enoyl-[acyl-carrier-protein] reductase (NADH) FabI is a NADH-dependent enoyl-ACP reductase and is involved in fatty acid biosynthesis. It catalyzes the reaction : Acyl-[acyl-carrier-protein] + NAD+ %3D trans-2%2C3-dehydroacyl-[acyl-carrier-protein] + NADH. It forms a homotetramer and binds A NAD+ per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4763 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4763 ZOBELLIA_4764 ZOBELLIA_4764 recN recN 5504022 5505674 - DNA repair protein RecN RecN is involved in recombinational repair of damaged DNA. It appears to be an early detector of breaks in double-stranded DNA. In vivo%2C RecN forms discrete nucleoid-associated structures and in vitro exhibits Mg2+-dependent single-stranded (ss) DNA binding and ssDNA-dependent ATPase activities. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4764 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4764 ZOBELLIA_4765 ZOBELLIA_4765 ZOBELLIA_4765 5505730 5506617 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene4765 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4765 ZOBELLIA_4766 ZOBELLIA_4766 coaBC coaBC 5506610 5507815 - Coenzyme A biosynthesis bifunctional protein coaBC CoaBC catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C in the latter compound is decarboxylated to form 4'-phosphopantotheine. It forms a homodecamer and binds one magnesium ion and one FMN as cofactor per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene4766 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4766 ZOBELLIA_4767 ZOBELLIA_4767 ZOBELLIA_4767 5507819 5508151 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene4767 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4767 ZOBELLIA_4768 ZOBELLIA_4768 ZOBELLIA_4768 5508164 5509000 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene4768 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4768 ZOBELLIA_4769 ZOBELLIA_4769 dapA2 dapA2 5509108 5509992 - Dihydrodipicolinate synthetase Dihydropicolinate synthase (DHDPS) is the key enzyme in lysine biosynthesis via the diaminopimelate pathway of prokaryotes%2C some phycomycetes and higher plants. The enzyme catalyses the condensation of L- aspartate-beta-semialdehyde and pyruvate to dihydropicolinic acid via a ping-pong mechanism in which pyruvate binds to the enzyme by forming a Schiff-base with a lysine residue%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene4769 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4769 ZOBELLIA_477 ZOBELLIA_477 ZOBELLIA_477 618119 618946 + RmlD substrate binding domain family protein Conserved protein belonging to the RmlD substrate binding domain family. In RlmB%2C this domain is responsible for binding a sugar nucleotide. The function of this protein is unclear%3B Localized in the cytoplasm%3B~Family membership gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_477 ZOBELLIA_4770 ZOBELLIA_4770 ZOBELLIA_4770 5509992 5510525 - Conserved hypothetical protein Localized in the cytoplasm gene gene4770 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4770 ZOBELLIA_4771 ZOBELLIA_4771 ZOBELLIA_4771 5510629 5511396 + 5'nucleotidase%2C substrate binding subunit The 5'nucleotidase is involved in the degradation of extracellular 5'-nucleotides into membrane permeable nucleosides. Usually it is composed of a N-terminal phosphatase domain and of a C-terminal alpha/beta fold domain with three conserved arginines which are involved in substrate binding and may also play a role in transition-state stabilization. This lipoprotein corresponds only to this latter domain%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane probably associated with the phosphatase subunit%3B~Function unclear gene gene4771 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4771 ZOBELLIA_4772 ZOBELLIA_4772 nutA nutA 5511455 5512366 + 5'-Nucleotidase%2C phosphatase subunit The 5'-Nucleotidase is involved in the degradation of extracellular 5'-nucleotides into membrane permeable nucleosides. Usually It is composed of a N-terminal phosphatase domain that provides the ligands to the dimetal cluster and a conserved histidine%2C which together form the catalytic site and of a C-terminal domain involved in the substrate binding%3B This lipoprotein corresponds only to the phosphatase domain that hydrolyses the phosphate esterified at carbon 5' of the ribose and deoxyribose portions of nucleotide molecules%3B Binds a chloride ion and a magnesium ion as cofactors%3B Signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane probably associated with the substrate binding subunit%3B~High confidence in function and specificity gene gene4772 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4772 ZOBELLIA_4773 ZOBELLIA_4773 ZOBELLIA_4773 5512369 5512821 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4773 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4773 ZOBELLIA_4774 ZOBELLIA_4774 ZOBELLIA_4774 5512813 5513124 - Conserved hypothetical protein Localized in the cytoplasm gene gene4774 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4774 ZOBELLIA_4775 ZOBELLIA_4775 ZOBELLIA_4775 5513196 5514446 + Hypothetical membrane protein Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene4775 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4775 ZOBELLIA_4776 ZOBELLIA_4776 ligA ligA 5514477 5516474 - DNA ligase DNA ligase catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'- hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4776 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4776 ZOBELLIA_4777 ZOBELLIA_4777 hemK hemK 5516535 5517398 - Protein methyltransferase HemK Protein methyltransferase hemK plays a role in translational termination. It methylates at GGQ sites the translation termination release factors RF1 and RF2%3B Uses S-adenosylmethionine as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4777 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4777 ZOBELLIA_4778 ZOBELLIA_4778 yjgM yjgM 5517417 5517893 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene4778 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4778 ZOBELLIA_4779 ZOBELLIA_4779 ribD ribD 5517991 5519076 + Riboflavin biosynthesis protein ribD RibD is involved in the biosynthesis of riboflavin (vitamin B2)%2C the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). It is a bifunctional enzyme catalyzing the second and third steps in the vitamin B2 biosynthesis: the deamination of 2%2C5-diamino-6-ribosylamino-4(3H)- pyrimidinone 5'-phosphate and the subsequent reduction of the ribosyl side chain%3B Contains a N-terminal diaminohydroxyphosphoribosylaminopyrimidine deaminase module belonging to the cytidine and deoxycytidylate deaminase family and a C-terminal 5-amino-6-(5-phosphoribosylamino)uracil reductase module belonging to the HTP reductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4779 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4779 ZOBELLIA_478 ZOBELLIA_478 pcbD pcbD 619037 619324 + Pterin-4-alpha-carbinolamine dehydratase Pterin-4-alpha-carbinolamine dehydratase is involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. It catalyzes the the dehydration of 4a-hydroxytetrahydrobiopterins. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_478 ZOBELLIA_4780 ZOBELLIA_4780 yihX yihX 5519069 5519674 + Phosphatase YihX Phosphatase YihX catalyzes the dephosphorylation of the beta-glucose 1-phosphate%3B Belongs to the haloacid dehalogenase-like hydrolase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene4780 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4780 ZOBELLIA_4781 ZOBELLIA_4781 ZOBELLIA_4781 5519676 5520539 + Conserved hypothetical membrane protein Protein containing two DUF6 family domain%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene4781 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4781 ZOBELLIA_4782 ZOBELLIA_4782 ZOBELLIA_4782 5520539 5521144 + Protein IMPACT homolog Protein belonging to the IMPACT ((Imprinted and ancient gene protein homolog) family (UPF0029 family)%3B Localized in the cytoplasm%3B~Family membership gene gene4782 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4782 ZOBELLIA_4783 ZOBELLIA_4783 ybgC2 ybgC2 5521233 5521592 - Acyl-CoA thioester hydrolase Acyl-CoA thioester hydrolase is involved in fatty acid biosynthesis catalyzing the hydrolysis of the thioester bond in acyl-CoA to give the corresponding fatty acid and CoA%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene4783 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_4783 ZOBELLIA_479 ZOBELLIA_479 ZOBELLIA_479 619475 620185 + Conserved hypothetical protein Conserved protein belonging to the DUF28 family%3B Localized in the cytoplasm%3B~Family membership gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_479 ZOBELLIA_48 ZOBELLIA_48 ZOBELLIA_48 48469 49011 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_48 ZOBELLIA_480 ZOBELLIA_480 ZOBELLIA_480 620302 620841 - Acyltransferase family protein Conserved protein belonging to the acyltransferase family. Its exact function is unknown%3B Localized in the cytoplasm%3B~Family membership gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_480 ZOBELLIA_481 ZOBELLIA_481 ZOBELLIA_481 620920 622047 - Iron-containing alcohol dehydrogenase Iron-containing alcohol dehydrogenase catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. Its exact specificity is unclear. It uses NAD as cofactor. Localized in the cytoplasm.%3B~Specificity unclear gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_481 ZOBELLIA_482 ZOBELLIA_482 nanP nanP 622052 622753 - N-Acylneuraminate-9-phosphatase N-Acylneuraminate-9-phosphatase (Neu5Ac-9-Pase)is involved in the aminosugar metabolism. It converts the N-acylneuraminate 9-phosphate to N-acylneuraminate. It binds one magnesium ion as cofactor%3B Belongs to the haloacid dehalogenase-like hydrolase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_482 ZOBELLIA_483 ZOBELLIA_483 kdsB kdsB 622744 623457 - 3-Deoxy-manno-octulosonate cytidylyltransferase The 3-Deoxy-manno-octulosonate cytidylyltransferase%2C also known as CMP-KDO synthetase%2C activates KDO (a 8-carbon sugar) required for incorporation into bacterial lipopolysaccharide in Gram- negative bacteria%3B It binds one magnesium ion as cofactor%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_483 ZOBELLIA_484 ZOBELLIA_484 ZOBELLIA_484 623564 624133 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_484 ZOBELLIA_485 ZOBELLIA_485 recD recD 624239 625672 - Exodeoxyribonuclease V%2C alpha chain The Exonuclease V is a multifunctional nuclease required for efficient DNA repair. It catalyzes the unwinding of double-stranded DNA and the cleavage of single-stranded DNA and it stimulates local genetic recombination. All of these activities require concomitant hydrolysis of ATP%3B Belongs to the helicase family%2C UvrD subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_485 ZOBELLIA_486 ZOBELLIA_486 ZOBELLIA_486 625780 626433 + Conserved hypothetical protein Localized in the cytoplasm gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_486 ZOBELLIA_487 ZOBELLIA_487 ZOBELLIA_487 626408 627241 + Conserved hypothetical protein Localized in the cytoplasm gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_487 ZOBELLIA_488 ZOBELLIA_488 ZOBELLIA_488 627241 627795 + Conserved hypothetical protein Conserved hypothetical protein predicted as a methyltransferase%3B Localized in the cytoplasm gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_488 ZOBELLIA_489 ZOBELLIA_489 dnaX dnaX 628240 630063 + DNA polymerase III%2C gamma/tau chain The tau chain of DNA polymerase III is a scaffold to help in the dimerizaton of the alpha chain in core enzyme. It is a 'motor' ATPase. The gamma chain is a part of the clamp loader and seems to interact with the delta chain to transfer the beta chain on the DNA. It is a 'motor' ATPase that has the active site for the clamp loader. The gamma chain is the product of the same gene as the tau subunit and has the same amino-terminus%3B The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_489 ZOBELLIA_49 ZOBELLIA_49 ZOBELLIA_49 49066 49611 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene49 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_49 ZOBELLIA_490 ZOBELLIA_490 ZOBELLIA_490 630052 630414 - Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_490 ZOBELLIA_491 ZOBELLIA_491 ZOBELLIA_491 630411 631790 - Type I phosphodiesterase Type I phosphodiesterase catalyzes the cleavage of phosphodiester and phosphosulfate bonds in various substrates such as NAD%2C deoxynucleotides and nucleotide sugars. The exact specificity of this enzyme is not known%3B Localized in the cytoplasm%3B~Family membership gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_491 ZOBELLIA_492 ZOBELLIA_492 ZOBELLIA_492 631794 632987 - Conserved hypothetical protein Localized in the cytoplasm gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_492 ZOBELLIA_493 ZOBELLIA_493 aroB1 aroB1 632989 634149 - 3-Dehydroquinate synthase 3-Dehydroquinate synthase is involved in the biosynthesis of aromatic amino acids. It catalyzes the second step of the shikimate pathway%2C the formation of dehydroquinate and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. It forms a monomer and binds NAD and divalent metal cation as cofactors. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_493 ZOBELLIA_494 ZOBELLIA_494 ZOBELLIA_494 634184 635086 - UbiA prenyltransferase family protein Conserved protein belonging to the UbiA prenyltransferase family%2C which includes various prenyltransferases%2C but also cytochrome C oxidase assembly factor. The exact function of this protein is unclear%3B Contains nine transmembrane helices. Localized in the cytoplasmic membrane%3B~Family membership gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_494 ZOBELLIA_495 ZOBELLIA_495 ZOBELLIA_495 635086 635994 - TatD family protein Conserved protein belonging to the TatD family. These enzymes adopt a TIM barrel fold%3B Localized in the cytoplasm%3B~Family membership gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_495 ZOBELLIA_496 ZOBELLIA_496 ZOBELLIA_496 635996 636853 - Conserved hypothetical protein Localized in the cytoplasm. gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_496 ZOBELLIA_497 ZOBELLIA_497 miaE miaE 637032 637613 + tRNA-(ms[2]io[6]A)-hydroxylase MiaE is involved in the production of the modified nucleoside 2-methylthio-cis-ribozeatin (MS[2]IO[6]A) found in some tRNAs. Catalyzes the oxygen-dependent transformation of MS[2]I[6]A into MS[2]IO[6]A. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_497 ZOBELLIA_498 ZOBELLIA_498 ppk1 ppk1 637654 639759 - Polyphosphate kinase 1 Polyphosphate kinase 1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to histidine residues through a N-P bond. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_498 ZOBELLIA_499 ZOBELLIA_499 ZOBELLIA_499 639760 640245 - Phosphoglycerate mutase family protein Conserved protein belonging to the phosphoglycerate mutase family. Its exact function is unclear. Localized in the cytoplasm.%3B~Family membership gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_499 ZOBELLIA_5 ZOBELLIA_5 ZOBELLIA_5 4418 5461 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Belongs to the aminodeoxychorismate lyase family%3B Localized in the periplasmic space%3B~Family membership gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_5 ZOBELLIA_50 ZOBELLIA_50 ZOBELLIA_50 49671 50213 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene50 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_50 ZOBELLIA_500 ZOBELLIA_500 pdxH1 pdxH1 640306 640953 - Pyridoxamine 5'-phosphate oxidase Pyridoxamine 5'-phosphate oxidase is involved in the vitamine B6 metabolism. It oxidizes pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). It forms a homodimer and binds one FMN as cofactor per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_500 ZOBELLIA_501 ZOBELLIA_501 rrnA rrnA 641023 641928 - Ribonuclease Z Ribonuclease Z is a zinc phosphodiesterase%2C which displays a tRNA 3'-processing endonuclease activity. It is probably involved in tRNA maturation%2C by removing a 3' trailer from precursor tRNA%3B It catalyses a endonucleolytic cleavage of RNA%2C removing extra 3' nucleotides from tRNA precursor%2C generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule%3B Binds 2 zinc ions%3B Belongs to the metallo-beta-lactamase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_501 ZOBELLIA_502 ZOBELLIA_502 ZOBELLIA_502 641936 642409 - Conserved hypothetical protein Localized in the cytoplasm gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_502 ZOBELLIA_503 ZOBELLIA_503 ZOBELLIA_503 642406 642738 - Conserved hypothetical protein Localized in the cytoplasm gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_503 ZOBELLIA_504 ZOBELLIA_504 pyrB pyrB 642746 643672 - Aspartate carbamoyltransferase Aspartate carbamoyltransferase catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate (). This is the second step in the de novo biosynthesis of pyrimidine nucleotides%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_504 ZOBELLIA_505 ZOBELLIA_505 pyrR1 pyrR1 643675 644214 - Bifunctional protein pyrR PyrR regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator%2C leading to a reduced expression of downstream genes. Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. It forms in equilibrium a homodimer and a homohexamer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_505 ZOBELLIA_506 ZOBELLIA_506 rpsA rpsA 644445 646277 - Ribosomal protein S1 The ribosomal protein S1 is a part of the ribosomal small subunit. It binds mRNA through six S1 domains with some degree of sequence specificity%2C facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno sequence%3B Some nascent polypeptide chains are able to cross-link to this protein in situ. Can be cross-linked to mRNA in the ribosome%3B Contains 6 S1 motif domains found in a large number of RNA-associated proteins%3B Belongs to the ribosomal protein S1P family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_506 ZOBELLIA_507 ZOBELLIA_507 ygaU ygaU 646548 646928 + Protein YgaU%2C family CBM50 Protein YgaU contains a C-terminal peptidoglycan-binding LysM domain. LysM domains belongs to the family 50 of the carbohydrate binding modules (CBM50). Localized in the cytoplasm.%3B~Family membership gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_507 ZOBELLIA_508 ZOBELLIA_508 cmk cmk 646983 647675 - Cytidylate kinase Cytidylate kinase is involved in pyrimidine nucleotide metabolism. It catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_508 ZOBELLIA_509 ZOBELLIA_509 lonA lonA 647675 650143 - Endopeptidase La%2C family S16 Endopeptidase La degrades short-lived regulatory and abnormal proteins in the presence of ATP. Hydrolyzes two ATP for each peptide bond cleaved in the protein substrate. Belongs to the family S16 of the serine peptidases. The catalytic dyad consists of Ser and Lys residues. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_509 ZOBELLIA_51 ZOBELLIA_51 ZOBELLIA_51 50230 50679 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene51 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_51 ZOBELLIA_510 ZOBELLIA_510 ZOBELLIA_510 650212 650304 + Putative protein Hypothetical protein gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_510 ZOBELLIA_511 ZOBELLIA_511 ZOBELLIA_511 650328 650912 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_511 ZOBELLIA_512 ZOBELLIA_512 ZOBELLIA_512 650916 651473 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_512 ZOBELLIA_513 ZOBELLIA_513 ZOBELLIA_513 651454 652545 + Conserved hypothetical protein Localized in the cytoplasm gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_513 ZOBELLIA_514 ZOBELLIA_514 ZOBELLIA_514 652580 653302 + Conserved hypothetical protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_514 ZOBELLIA_515 ZOBELLIA_515 ZOBELLIA_515 653346 654671 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients%3B Contains 10 transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_515 ZOBELLIA_516 ZOBELLIA_516 ZOBELLIA_516 654738 655550 - Metallopeptidase%2C family M48 Metallopeptidases hydrolyze the peptidic bonds in proteins and peptides with a single catalytic zinc ion tetrahedrally co-ordinated by two histidines within an HEXXH motif%2C an as yet undetermined third residue as well as a water molecule. The glutamate residue within the HEXXH motif is essential for catalysis%3B Belongs to the M48 family of peptidases%3B Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_516 ZOBELLIA_517 ZOBELLIA_517 malA malA 655586 657985 - Alpha-glucosidase%2C family GH31 Alpha-glucosidase catalyzes the hydrolysis of terminal%2C non-reducing 1%2C4-linked alpha-D-glucose residues with release of alpha-D-glucose. It belongs to the family 31 of the glycoside hydrolases. Involved in starch or glycogen metabolism.%3B~High confidence in function and specificity gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_517 ZOBELLIA_518 ZOBELLIA_518 glgB glgB 658086 659987 - 1%2C4-alpha-glucan branching enzyme%2C family GH13 1%2C4-alpha-glucan branching enzyme catalyzes the formation of the alpha-1%2C6-glucosidic linkages in glycogen by scission of a 1%2C4-alpha-linked oligosaccharide from growing alpha-1%2C4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1%2C6 position. Has a preference for transferring chains of 5 to 16 glucose units. Belongs to the family 13 of the glycoside hydrolases.%3B~High confidence in function and specificity gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_518 ZOBELLIA_519 ZOBELLIA_519 ZOBELLIA_519 660185 660757 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_519 ZOBELLIA_52 ZOBELLIA_52 ZOBELLIA_52 50666 51175 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released. They alter the specificity of promoter recognition. This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors. Localized in the cytoplasm.%3B~Family membership gene gene52 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_52 ZOBELLIA_520 ZOBELLIA_520 ZOBELLIA_520 660812 660910 - Putative protein Hypothetical protein gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_520 ZOBELLIA_521 ZOBELLIA_521 msrB1 msrB1 660929 661432 + Peptide methionine sulfoxide reductase msrB Peptide methionine sulphoxide reductase reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide to methionine. MsrB is specific for methionine-R-sulfoxides. It activates the cysteine or selenocysteine nucleophile through a unique Cys-Arg-Asp/Glu catalytic triad. Regeneration of the active site occurs through a series of thiol-disulfide exchange steps involving another active site Cys residue and thioredoxin. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_521 ZOBELLIA_522 ZOBELLIA_522 ZOBELLIA_522 661488 662015 + Conserved hypothetical protein Conserved protein belonging to the DUF1572 family%3B Localized in the cytoplasm gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_522 ZOBELLIA_523 ZOBELLIA_523 bfmBC bfmBC 662180 663571 + Dihydrolipoyl dehydrogenase%2C E3 component The Dihydrolipoyl dehydrogenase is the E3 component of the branched-chain alpha-keto dehydrogenase complex. This complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine%2C leucine and isoleucine biodegradation. It contains multiple copies of three enzymatic components: branched- chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The E3 component converts the Protein 6-N-(dihydrolipoyl)lysine to protein 6-N-(lipoyl)lysine. Dihydrolipoyl dehydrogenase is a homodimer%2C which binds 1 NADP and 1 FAD per subunit%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene523 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_523 ZOBELLIA_524 ZOBELLIA_524 ZOBELLIA_524 663675 663965 + Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_524 ZOBELLIA_525 ZOBELLIA_525 ZOBELLIA_525 663983 664501 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_525 ZOBELLIA_526 ZOBELLIA_526 aroQ aroQ 664681 665097 - 3-dehydroquinate dehydratase 3-dehydroquinate dehydratase (or dehydroquinases) catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. AroQ belongs to the class II of the dehydroquinases. It forms a homododecamer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_526 ZOBELLIA_527 ZOBELLIA_527 ZOBELLIA_527 665191 665811 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 32 and 33%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_527 ZOBELLIA_528 ZOBELLIA_528 xerD xerD 666023 666919 + Tyrosine recombinase XerD Tyrosine recombinase XerD acts by catalyzing the cutting and rejoining of the recombining DNA molecules utilizing a catalytic tyrosine for the strand cleavage%3B The cyclic heterotetrameric complex is composed of two molecules of XerC and two molecules of XerD. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites%3B Belongs to the \\phage\\ integrase family%2C XerD and XerC integrases subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene528 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_528 ZOBELLIA_529 ZOBELLIA_529 ZOBELLIA_529 666926 667432 - Hypothetical protein Localized in the cytoplasm gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_529 ZOBELLIA_53 ZOBELLIA_53 ZOBELLIA_53 51415 52905 + Carboxy-terminal processing peptidase%2C family S41 This peptidase is a modular protein that shows specific recognition for the C-terminal tripeptide%2C Xaa-Yaa-Zaa (preferably Ala or Leu%2C Ala or Tyr and Ala respectively). The cleavage occurs at a variable distance from the C-terminus%3B Contains a N-terminal domain of unknown function and a central PDZ domain involved in protein-protein interaction. In many cases%2C PDZ domain binds to a signature motif ([FYST]-X-[FVA]) occurring at the very C-terminus of target proteins%3B Belongs to the family S41 of the serine peptidases%3B Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_53 ZOBELLIA_530 ZOBELLIA_530 malL malL 667655 669349 + Oligo-1%2C6-glucosidase%2C family GH13 Oligo-1%2C6-glucosidase catalyzes the hydrolysis of 1%2C 6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase%2C and in isomaltose%3B Belongs to the family 13 of the glycoside hydrolases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_530 ZOBELLIA_531 ZOBELLIA_531 ndhA1 ndhA1 669334 670659 - NADH dehydrogenase NADH dehydrogenases catalyze the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation%3B Binds 1 FAD noncovalently per subunit%3B Contains one tranmembrane segment%3B Belongs to the NADH dehydrogenase family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_531 ZOBELLIA_532 ZOBELLIA_532 ZOBELLIA_532 670986 671480 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_532 ZOBELLIA_533 ZOBELLIA_533 ZOBELLIA_533 671485 672135 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_533 ZOBELLIA_534 ZOBELLIA_534 ZOBELLIA_534 672132 672947 - Acyltransferase Acyltransferase catalyzes of the generalized reaction: acyl-carrier + reactant %3D acyl-reactant + carrier. This enzyme belongs to an acyltransferase family including enzymes involved in phospholipid biosynthesis. Its exact specificity is unknown. Localized in the cytoplasm.%3B~Specificity unclear gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_534 ZOBELLIA_535 ZOBELLIA_535 ZOBELLIA_535 673616 674329 + Cyclophilin-type peptidyl-prolyl cis-trans isomerase Peptidyl-prolyl cis-trans isomerase%2C or PPIase or rotamase%2C accelerates the folding of proteins. It catalyzes the peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation in oligopeptides%3B Contains a C-terminal Cyclophilin-type peptidyl-prolyl cis-trans isomerase/CLD domain%3B Signal peptide of lipoprotein cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_535 ZOBELLIA_536 ZOBELLIA_536 ZOBELLIA_536 672973 673617 - NUDIX hydrolase NUDIX hydrolase belongs to a family of enzymes hydrolyzing diverse nucleoside diphosphate derivatives (including ADP-ribose%2C GDP- mannose%2C TDP-glucose%2C NADH%2C UDP-sugars%2C dNTP and NTP). Localized in the cytoplasm.%3B~Function unclear gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_536 ZOBELLIA_537 ZOBELLIA_537 ZOBELLIA_537 674343 674960 - Conserved hypothetical membrane protein Conserved membrane protein containing two UPF0126 domains. The conserved glycines are suggestive of an ion channel. Contains seven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_537 ZOBELLIA_538 ZOBELLIA_538 ZOBELLIA_538 675021 675737 - RDD family membrane protein This family of proteins contain three highly conserved amino acids: one arginine and two aspartates%2C hence the name of RDD family. Contains three transmembrane helices. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this protein is unknown%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_538 ZOBELLIA_539 ZOBELLIA_539 ZOBELLIA_539 675770 676729 + Conserved hypothetical membrane protein Conserved integral membrane protein belonging to the DUF95 family. Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_539 ZOBELLIA_54 ZOBELLIA_54 ZOBELLIA_54 52990 54480 + Carboxy-terminal processing peptidase%2C family S41 This peptidase is a modular protein that shows specific recognition for the C-terminal tripeptide%2C Xaa-Yaa-Zaa (preferably Ala or Leu%2C Ala or Tyr and Ala respectively). The cleavage occurs at a variable distance from the C-terminus%3B Contains a N-terminal domain of unknown function and a central PDZ domain involved in protein-protein interaction. In many cases%2C PDZ domain binds to a signature motif ([FYST]-X-[FVA]) occurring at the very C-terminus of target proteins%3B Belongs to the family S41 of the serine peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_54 ZOBELLIA_540 ZOBELLIA_540 ZOBELLIA_540 676726 677598 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_540 ZOBELLIA_541 ZOBELLIA_541 ZOBELLIA_541 677601 678341 + Conserved hypothetical membrane protein Contains one central transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_541 ZOBELLIA_542 ZOBELLIA_542 ZOBELLIA_542 678334 679557 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_542 ZOBELLIA_543 ZOBELLIA_543 ZOBELLIA_543 679535 680533 + MoxR-like ATPase ATPase belonging to the MoxR-like family. In Paracoccus denitrificans%2C MoxR is involved in the regulation of formation of active methanol dehydrogenase. MoxR-like ATPases have been proposed to function with VWA domain proteins to form a chaperone system involved in the activation of proteins by primarily mediating the insertion of metal cofactors into the substrate molecules%3B Localized in the cytoplasm%3B~Specificity unclear gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_543 ZOBELLIA_544 ZOBELLIA_544 ZOBELLIA_544 680536 681867 + vWA domain protein Conserved protein belonging to the von Willebrand factor type A (vWA) domain family. Some VWA domain proteins have been proposed to function with MoxR-like ATPases to form a chaperone system involved in the activation of proteins by primarily mediating the insertion of metal cofactors into the substrate molecules. Contains two N-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_544 ZOBELLIA_545 ZOBELLIA_545 ZOBELLIA_545 681946 682155 + Putative protein Hypothetical protein gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_545 ZOBELLIA_546 ZOBELLIA_546 ZOBELLIA_546 682163 682696 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_546 ZOBELLIA_547 ZOBELLIA_547 ZOBELLIA_547 682841 683860 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_547 ZOBELLIA_548 ZOBELLIA_548 ZOBELLIA_548 683886 684401 + Conserved hypothetical protein Localized in the cytoplasm gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_548 ZOBELLIA_549 ZOBELLIA_549 ZOBELLIA_549 684504 684728 + Conserved hypothetical protein Localized in the cytoplasm. gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_549 ZOBELLIA_55 ZOBELLIA_55 ZOBELLIA_55 54556 55461 - Conserved hypothetical protein Localized in the cytoplasm. gene gene55 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_55 ZOBELLIA_550 ZOBELLIA_550 ZOBELLIA_550 684807 688217 + Cytochrome c-containing protein Protein containing a N-terminal beta-propeller fold domain%2C three central PBS lyase HEAT-like repeats and a C-terminal cytochrome c domain. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Function unclear gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_550 ZOBELLIA_551 ZOBELLIA_551 ncd1 ncd1 688287 689228 - 2-Nitropropane dioxygenase 2-Nitropropane dioxygenase catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds. It acts on 2-nitropropane better than on nitroethane and 1-nitropropane%2C and anionic forms of nitroalkanes are much better substrates than are neutral forms. It forms a homodimer and uses FMN as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_551 ZOBELLIA_552 ZOBELLIA_552 trmU trmU 689253 690512 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU modified the wobble bases of bacterial tRNAs responsible for NNR codons to 5-methylaminomethyl-2-thiouridine (mnm5s2U). 2-thio modification of mnm5s2U is required for accurate decoding and essential for normal cell growth. It uses S-adenosyl-L-methionine as cofactor. Interacts with tusE. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_552 ZOBELLIA_553 ZOBELLIA_553 ZOBELLIA_553 690672 692042 + Fasciclin repeats protein Conserved protein containing three fascilin domains. These domains%2C also known as FAS1 or BIgH3 domains%2C are extracellular modules of about 140 amino acid residues. In Eukaryotes%2C they mediate cell adhesion throught an interaction with alpha3/beta1 integrin. Each fascilin domain consists of seven-stranded wedge and at least five alpha helices. Features a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Family membership gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_553 ZOBELLIA_554 ZOBELLIA_554 oxaA oxaA 692406 694256 - Inner membrane protein oxaA OxaA is an inner membrane protein required for the insertion of integral membrane proteins into the membrane. It is a component of the SecDFyajC complex%2C a heterotetrameric translocase complex%2C interacting with secD and secF. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_554 ZOBELLIA_555 ZOBELLIA_555 pyrG pyrG 694385 696001 - CTP synthase CTP synthase is involved in pyrimidine nucleotide biosynthesis. It catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. It forms a homotetramer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_555 ZOBELLIA_556 ZOBELLIA_556 ZOBELLIA_556 696060 696299 - Conserved hypothetical protein Localized in the cytoplasm. gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_556 ZOBELLIA_557 ZOBELLIA_557 ZOBELLIA_557 696343 697212 + Xylose isomerase-like TIM barrel family Belongs to the xylose isomerase-like TIM barrel family. Exported by the twin-arginine translocation pathway signal.%3B~Specificity unclear gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_557 ZOBELLIA_558 ZOBELLIA_558 ZOBELLIA_558 697247 697993 - Two-component system-Response regulator The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity%2C a LytTR-type HTH domain%2C that acts as transcriptional regulator%3B~Family membership gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_558 ZOBELLIA_559 ZOBELLIA_559 ZOBELLIA_559 698001 700079 - Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Signal peptide cleaved between the residues 22 and 23%3B Contains seven tetratrico peptide repeats (TPR) and one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_559 ZOBELLIA_56 ZOBELLIA_56 btuB btuB 55494 57368 - Vitamin B12 TonB-dependent receptor BtuB protein is localized in the outer membrane and involved in the active translocation of vitamin B12 (cobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein tonB%3B Contains a N-terminal Plug module (46-157) acting as a channel gate. The signal peptide is cleaved between the residues 20 and 21.%3B~High confidence in function and specificity gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_56 ZOBELLIA_560 ZOBELLIA_560 ZOBELLIA_560 700133 700294 - Conserved hypothetical membrane protein Contains one transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_560 ZOBELLIA_561 ZOBELLIA_561 ZOBELLIA_561 700324 700983 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene561 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_561 ZOBELLIA_562 ZOBELLIA_562 ZOBELLIA_562 701020 701304 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Hypothetical protein gene gene562 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_562 ZOBELLIA_563 ZOBELLIA_563 ZOBELLIA_563 701346 701900 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Hypothetical protein gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_563 ZOBELLIA_564 ZOBELLIA_564 ZOBELLIA_564 702085 702615 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_564 ZOBELLIA_565 ZOBELLIA_565 ZOBELLIA_565 702652 703149 - Conserved hypothetical protein Localized in the cytoplasm. gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_565 ZOBELLIA_566 ZOBELLIA_566 ZOBELLIA_566 703188 703592 - OsmC family protein This protein belongs to a family including OsmC%2C the osmotically inducible protein C%3B localized in the cytoplasm%3B~Family membership gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_566 ZOBELLIA_567 ZOBELLIA_567 ZOBELLIA_567 703687 705855 - CBM50-containing protein Conserved protein containing five N-terminal LysM repeats and a C-terminal domain of unknown function. The LysM (lysin motif) domain is about 40 residues long and belongs to the family 50 of the carbohydrate binding modules (CBM50). It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. Features a signal peptide cleaved between the residues 23 and 24. Localized in the periplasm.%3B~Function unclear gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_567 ZOBELLIA_568 ZOBELLIA_568 guaA guaA 705858 707390 - GMP synthase [glutamine-hydrolyzing] The GMP synthase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. It catalyzes the synthesis of guanosine 5'monophosphate (GMP) from xanthosine 5'monophosphate (XMP)%2C ATP and glutamine%3B Belongs to the Glutamine amidotransferase%2C class I family defined by a conserved catalytic triad consisting of cysteine%2C histidine and glutamate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_568 ZOBELLIA_569 ZOBELLIA_569 ZOBELLIA_569 707433 707678 + Putative protein Hypothetical protein gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_569 ZOBELLIA_57 ZOBELLIA_57 fkpA fkpA 57741 58379 - FKBP-type peptidyl-prolyl cis-trans isomerase Peptidyl-prolyl cis-trans isomerase%2C or PPIase or rotamase%2C accelerates the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_57 ZOBELLIA_570 ZOBELLIA_570 ZOBELLIA_570 707988 710459 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (57-134) and the Plug module (152-258) acting as a channel gate%3B The signal peptide is cleaved between the residues 20 and 21%3B~Family membership gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_570 ZOBELLIA_571 ZOBELLIA_571 ZOBELLIA_571 710463 710918 + Putative membrane lipoprotein Contains a lipoprotein signal peptide cleaved between the residues 17 and 18%3B Probably localized in the outer membrane%3B~Hypothetical protein gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_571 ZOBELLIA_572 ZOBELLIA_572 ZOBELLIA_572 711037 711351 + Hypothetical protein Putatively localized in the cytoplasm gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_572 ZOBELLIA_573 ZOBELLIA_573 pdxH2 pdxH2 711534 712076 + Pyridoxamine 5'-phosphate oxidase Pyridoxamine 5'-phosphate oxidase is involved in the vitamine B6 metabolism. It oxidizes pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). It forms a homodimer and binds one FMN as cofactor per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_573 ZOBELLIA_574 ZOBELLIA_574 ZOBELLIA_574 712088 713689 - Conserved hypothetical protein Localized in the cytoplasm gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_574 ZOBELLIA_575 ZOBELLIA_575 ZOBELLIA_575 713840 716305 + Metallopeptidase%2C family M14 Peptidase family M14 contains mainly metallocarboxypeptidases. The single catalytic zinc ion is tetrahedrally coordinated by two histidines and a glutamate%2C as well as a water molecule. One of the histidines and the glutamate occur in the motif His-Xaa-Xaa-Glu%3B Signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Specificity unclear gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_575 ZOBELLIA_576 ZOBELLIA_576 ZOBELLIA_576 716344 717390 + Metallo-beta-lactamase superfamily protein Conserved protein belonging to the zinc-dependent beta-lactamase superfamily. This superfamily contains various metallo-hydrolases including beta-lactamases%2C but also glyoxylases and arylsulfatases. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions. Localized in the cytoplasm%3B~Family membership gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_576 ZOBELLIA_577 ZOBELLIA_577 ZOBELLIA_577 717425 718030 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_577 ZOBELLIA_578 ZOBELLIA_578 ZOBELLIA_578 718241 718750 + GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_578 ZOBELLIA_579 ZOBELLIA_579 ZOBELLIA_579 718912 719844 + Conserved hypothetical protein Localized in the cytoplasm gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_579 ZOBELLIA_58 ZOBELLIA_58 btuF btuF 58406 59554 + Vitamin B12 ABC importer%2C periplasmic component Part of the ABC transporter complex btuCDF involved in vitamin B12 import. Binds cobalamin (vitamin B12) and delivers it to the periplasmic surface of btuC%3B Contains 1 Fe/B12 periplasmic-binding domain%3B belong to the TroA superfamily%2C btuF family%3B Signal peptide of lipoprotein cleaved between the residues 15 and 16%3B Periplasmic protein anchored in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_58 ZOBELLIA_580 ZOBELLIA_580 arsR arsR 719943 720272 + Arsenical resistance operon repressor Arsr is the transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of arsR is alleviated by oxyions of +III oxidation state of arsenic%2C antimony%2C and bismuth%2C as well as arsenate (As(V)). Contains 1 HTH arsR-type DNA-binding domain. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_580 ZOBELLIA_581 ZOBELLIA_581 ZOBELLIA_581 720323 720790 + Conserved hypothetical protein Localized in the cytoplasm gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_581 ZOBELLIA_582 ZOBELLIA_582 arsC arsC 720826 721452 + Protein arsC Protein arsC reduces arsenate [As(V)] to arsenite [As(III)] (Arsenate reductase%2C EC 1.20.4.-) and dephosphorylates tyrosine phosphorylated proteins%2C low-MW aryl phosphates and natural and synthetic acyl phosphates (LMW protein-tyrosine-phosphatase%2C EC 3.1.3.48). Could switch between different functions in different circumstances. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_582 ZOBELLIA_583 ZOBELLIA_583 arsB arsB 721445 722497 + Arsenite resistance protein Arsenite resistance protein ArsB seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump. Belongs to the Sodium Bile acid symporter family%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_583 ZOBELLIA_584 ZOBELLIA_584 cvrA cvrA 722684 724144 + Cell volume regulation protein A Cell volume regulation protein A participates in control of cell volume in low-osmolarity conditions. It belongs to the Na/H antiporters. This integral membrane protein also features a C-terminal TrkA-C domain which may bind an unidentified ligand and is predicted to adopt an all beta structure. Features eleven transmembrane helices.%3B~High confidence in function and specificity gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_584 ZOBELLIA_585 ZOBELLIA_585 ZOBELLIA_585 724189 724554 + Hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Hypothetical protein gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_585 ZOBELLIA_586 ZOBELLIA_586 ZOBELLIA_586 724657 725142 + Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_586 ZOBELLIA_587 ZOBELLIA_587 ZOBELLIA_587 725213 726211 - Gluconolactonase Gluconolactonases hydrolyze the gluconolactone formed by glucose oxidoreductase. The proximity of the galactonate dehydratase gene dgoD suggests that this lactonase would be specific for D-galactono-1%2C4-lactone instead of gluconolactone%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasm.%3B~Specificity unclear gene gene587 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_587 ZOBELLIA_588 ZOBELLIA_588 gntT1 gntT1 726247 727569 - High-affinity gluconate transporter GntT is part of the gluconate utilization system Gnt-I. It is a permease responsible for high-affinity intake of gluconate%3B Contains 13 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_588 ZOBELLIA_589 ZOBELLIA_589 dgoD dgoD 727641 728798 - Galactonate dehydratase Galactonate dehydratase%2C involved in the galactose metabolism%2C converts the D-galactonate to 2-dehydro-3-deoxy-D-galactonate %3B These enzymes feature a N-terminal domain with a Enolase N-terminal domain-like fold and a C-terminal TIM alpha/beta barrel fold%3B Belongs to the Mandelate racemase/muconate lactonizing enzyme family%3B Localized in the cytoplas%3B~High confidence in function and specificity gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_589 ZOBELLIA_59 ZOBELLIA_59 btuC btuC 59555 60586 + Vitamin B12 ABC importer%2C permease component Part of the ABC transporter complex btuCDF involved in vitamin B12 import. The complex is composed of two ATP-binding proteins (btuD)%2C two transmembrane proteins and a solute-binding protein (btuF)%3B Contains nine transmembrane segments%3B Belongs to the periplasmic binding-protein-dependent ABC transporter family%2C FecCD subfamily%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_59 ZOBELLIA_590 ZOBELLIA_590 ZOBELLIA_590 729010 730311 - MiaB-like tRNA modifying protein Contains a N-terminal UPF0004 domain of unknown function%2C a Radical SAM superfamily%2C MiaB family domain involved in 2-methylthioadenine formation and a C-terminal TRAM domain predicted to bind tRNA and deliver the RNA-modifying enzymatic domain to their targets%3B Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (SAM)%3B Localized in the cytoplasm%3B~Family membership gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_590 ZOBELLIA_591 ZOBELLIA_591 ZOBELLIA_591 730432 731532 + Serine peptidase%2C family S12 Serine peptidase which includes D-Ala-D-Ala carboxypeptidase B and aminopeptidase DmpB. The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa-Thr-Lys%3B Belongs to the family S12 of peptidases%3B Contains a prokaryotic lipoprotein signal peptide (cleavage between 18 and 19%3B Localized in the outer membrane%3B~Specificity unclear gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_591 ZOBELLIA_592 ZOBELLIA_592 ftsY ftsY 731522 732478 - Cell division protein FtsY The cell division protein FtsY is a functional homolog of SRP receptor. Probably involved in the reception and insertion of a subset of proteins at the cytoplasmic membrane. Binds to the ribosome in the presence of the SRP particle and a non-hydrolyzable GTP analog. This abolishes trigger factor binding to the ribosome. Subcellular localization studies revealed that FtsY is located in part at the cytoplasmic membrane with which it seems peripherally associated.%3B~High confidence in function and specificity gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_592 ZOBELLIA_593 ZOBELLIA_593 ZOBELLIA_593 732659 732811 - Conserved hypothetical protein Localized in the cytoplasm. gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_593 ZOBELLIA_594 ZOBELLIA_594 rpmG rpmG 732848 733030 - Ribosomal protein L33 Ribosomal protein L33 is one of the proteins from the large ribosomal subunit (50S)%3B L33 has been shown to be on the surface of 50S subunit%3B Belongs to the ribosomal protein L33p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_594 ZOBELLIA_595 ZOBELLIA_595 rpmB rpmB 733042 733278 - Ribosomal protein L28 Ribosomal protein L28 is a part of the large subunit (50S) of the ribosome%3B RpmB interacts with the proteins RplQ (L17) and RpmF (L32)%3B Belongs to the ribosomal protein L28p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_595 ZOBELLIA_596 ZOBELLIA_596 cinA cinA 733346 734596 - CinA-like protein Conserved protein belonging to the CinA family. Contains a N-terminal molybdopterin binding domain and a C-terminal Competence-damaged domain . CinA is the first gene in the competence-inducible (cin) operon%2C and is thought to be specifically required at some stage in the process of transformation. Localized in the cytoplasm.%3B~Function unclear gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_596 ZOBELLIA_597 ZOBELLIA_597 ZOBELLIA_597 734596 734934 - Hpt domain protein The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. The domain consists of six alpha helices containing a four-helix bundle-folding. Localized in the cytoplasm.%3B~Family membership gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_597 ZOBELLIA_598 ZOBELLIA_598 ZOBELLIA_598 734934 735545 - Fumarylacetoacetate hydrolase family protein Conserved protein belonging to the Fumarylacetoacetate hydrolase family%2C but its exact function is not known. Fumarylacetoacetate hydrolase is the last enzyme of the tyrosine catabolic pathway. Localized in the cytoplasm.%3B~Family membership gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_598 ZOBELLIA_599 ZOBELLIA_599 ZOBELLIA_599 735563 736339 - Exonuclease This Exonuclease probably exhibits a 3' to 5' deoxyribonuclease activity or a ribonuclease activity%3B Contains an exonuclease domain%3B Localized in the cytoplasm%3B~Family membership gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_599 ZOBELLIA_6 ZOBELLIA_6 ZOBELLIA_6 5461 5985 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_6 ZOBELLIA_60 ZOBELLIA_60 ZOBELLIA_60 60729 61604 + DUF1080 family protein Conserved protein belonging to the DUF1080 family. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm.%3B~Conserved hypothetical protein gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_60 ZOBELLIA_600 ZOBELLIA_600 bfmBAB bfmBAB 736633 737985 - Dihydrolipoyllysine-residue (2-methylpropanoyl) transferase%2C E2 component The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine%2C leucine and isoleucine biodegradation. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). This protein is the E2 component and catalyzes the reaction: 2-methylpropanoyl-CoA + enzyme 6-N-(dihydrolipoyl)lysine %3D CoA + enzyme 6-N-(S-(2-methylpropanoyl)dihydrolipoyl)lysine. It features one N-terminal lipoyl-binding domain%2C a central E3-binding domain%2C and a C-terminal catalytic domain belonging to the 2-oxoacid dehydrogenases acyltransferase family. The lipoyl-binding domain has a conserved lysine residue that covalently binds lipoic acid. This protein forms a 24-polypeptide structural core with octahedral symmetry. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_600 ZOBELLIA_601 ZOBELLIA_601 recR recR 738068 738688 - Recombination protein RecR Recombination protein RecR may play a role in DNA repair. It seems to be involved in an recBC-independent recombinational process of DNA repair. It may act with recF and recO. It contains a putative C4-type zinc finger in the N-terminal section%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_601 ZOBELLIA_602 ZOBELLIA_602 ZOBELLIA_602 738746 740224 + Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains 13 transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_602 ZOBELLIA_603 ZOBELLIA_603 ZOBELLIA_603 740287 740646 - Conserved hypothetical protein Localized in the cytoplasm. gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_603 ZOBELLIA_604 ZOBELLIA_604 fabH1 fabH1 740867 741874 - 3-oxoacyl-[acyl-carrier-protein] synthase III 3-oxoacyl-[acyl-carrier-protein] synthase III%2C also known as beta-ketoacyl-ACP synthase III%2C catalyses the reaction: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] %3D 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. This is the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain. Negatively regulated by acyl-ACP%2C possibly by binding to either the free enzyme or the acyl-enzyme intermediate%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene604 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_604 ZOBELLIA_605 ZOBELLIA_605 ZOBELLIA_605 741983 743293 - Protein kinase superfamily protein Conserved protein belonging to the protein kinase superfamily%3B Localized in the cytoplasm%3B~Family membership gene gene605 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_605 ZOBELLIA_606 ZOBELLIA_606 ZOBELLIA_606 743330 743986 - Conserved hypothetical protein Localized in the cytoplasm. gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_606 ZOBELLIA_607 ZOBELLIA_607 htpG htpG 744425 746314 + Chaperone protein htpG The heat shock protein HtpG is a molecular chaperone. Has ATPase activity. It forms a homodimer%3B Belongs to the HSP90 family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_607 ZOBELLIA_608 ZOBELLIA_608 ZOBELLIA_608 746509 746724 + Putative protein Hypothetical protein gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_608 ZOBELLIA_609 ZOBELLIA_609 ZOBELLIA_609 746386 746529 - Putative protein Hypothetical protein gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_609 ZOBELLIA_61 ZOBELLIA_61 btuD btuD 61709 62398 + Vitamin B12 ABC importer%2C ATPase component This protein is the nucleotide-binding domain (ABC ATPase) of the ABC transporter complex btuCDF involved in vitamin B12 import. It is responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Belongs to the ABC transporter family%2C vitamin B12 importer%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~High confidence in function and specificity gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_61 ZOBELLIA_610 ZOBELLIA_610 ZOBELLIA_610 746850 747224 + Cupin family protein This conserved protein adopts a beta barrel fold of the Cupin superfamily. Localized in the cytoplasm.%3B~Conserved hypothetical protein gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_610 ZOBELLIA_611 ZOBELLIA_611 mioX mioX 747279 748088 - Myo-inositol oxygenase Myo-inositol oxygenase is a non-heme iron enzyme%2C which catalyzes the conversion of myo-inositol to D-glucuronic acid . This enzyme can be either involved of in myo-inositol catabolism or in UDP-glucuronic acid biosynthesis. Localized in cytoplasm.%3B~High confidence in function and specificity gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_611 ZOBELLIA_612 ZOBELLIA_612 ZOBELLIA_612 748149 749747 - Sodium/solute symporter Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force%2C SMF) is used to drive solute accumulation against a concentration gradient%3B Contains fourteen transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_612 ZOBELLIA_613 ZOBELLIA_613 ZOBELLIA_613 749952 750593 + MOSC family protein This protein belongs to the MOSC (MOCO sulfurase C-terminal) family which encompasses beta-strand-rich domains identified in the molybdenum cofactor sulfurase. These MOSC domains contain an absolutely conserved cysteine and are predicted to be sulfur-carrier domains that receive sulfur abstracted by the pyridoxal phosphate- dependent NifS-like enzymes%2C on their conserved cysteine%2C and deliver it for the formation of diverse sulfur-metal clusters. Localized in the cytoplasm.%3B~Family membership gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_613 ZOBELLIA_614 ZOBELLIA_614 ZOBELLIA_614 750683 750943 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_614 ZOBELLIA_615 ZOBELLIA_615 ZOBELLIA_615 751012 751596 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_615 ZOBELLIA_616 ZOBELLIA_616 ZOBELLIA_616 751838 752707 + AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_616 ZOBELLIA_617 ZOBELLIA_617 alkB1 alkB1 752707 753306 + Alpha-ketoglutarate-dependent dioxygenase Alpha-ketoglutarate-dependent dioxygenase repairs alkylated DNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Has a strong preference for single-stranded DNA. May also act on RNA. Requires molecular oxygen%2C alpha-ketoglutarate and iron. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_617 ZOBELLIA_618 ZOBELLIA_618 nucS nucS 753493 754263 - Nuclease S1 Nuclease S1 hydrolyzes only single stranded DNA and RNA without apparent specificity for bases%3B Binds 3 zinc ions as cofactors%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_618 ZOBELLIA_619 ZOBELLIA_619 pbp1B pbp1B 754368 756617 + Penicillin-binding protein 1B%2C family GT51 Penicillin-binding protein 1B is a class A PBP involved in the synthesis of cross-linked peptidoglycan from the lipid II intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). The N-terminal domain belongs to the family 51 of the glycosyltransferases. Features an uncleaved signal peptide. Localized in the periplasm%2C anchored to the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_619 ZOBELLIA_62 ZOBELLIA_62 rmuC rmuC 62464 63810 + DNA recombination protein RmuC RmuC is involved in DNA recombination%2C but its exact function is unclear. It is suspected that it is either a structural protein that protects DNA against nuclease action%2C or is itself involved in DNA cleavage at the regions of DNA secondary structures. Localized in the cytoplasm.%3B~Function unclear gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_62 ZOBELLIA_620 ZOBELLIA_620 ZOBELLIA_620 756645 757448 + Hydrolase HAD superfamily The hydrolases of the superfamily HAD (Haloacid dehalogenase) catalyse a nucleophilic displacement reaction%2C with water as the sole co-substrate. They are structurally different from the alpha/beta hydrolase family (abhydrolase)%3B Belongs to the haloacid dehalogenase- like hydrolase superfamily%2C class II family%2C class IIB subfamily%3B Localized in the cytoplasm%3B~Family membership gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_620 ZOBELLIA_621 ZOBELLIA_621 ZOBELLIA_621 757480 758796 + DUF819 family membrane protein Conserved protein belonging to the DUF819 family. Features eleven transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_621 ZOBELLIA_622 ZOBELLIA_622 ZOBELLIA_622 758849 759532 + Conserved hypothetical protein Localized in the cytoplasm gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_622 ZOBELLIA_623 ZOBELLIA_623 ZOBELLIA_623 759536 760501 - Aldo/keto reductase related to aryl-alcohol dehydrogenases Oxydoreductase NADPH dependent%3B Belongs to the aldo/keto reductase 2 family%3B Localized in the cytoplasm%3B~Family membership gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_623 ZOBELLIA_624 ZOBELLIA_624 ZOBELLIA_624 760512 762080 - UPF0061 family protein Conserved protein belonging to the UPF0061 family%3B Localized in the cytoplasm%3B~Family membership gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_624 ZOBELLIA_625 ZOBELLIA_625 rpiA rpiA 762128 762802 - Ribose-5-phosphate isomerase A Ribose-5-phosphate isomerase is involved in pentose phosphate pathway. It catalyzes the reaction: D-ribose 5-phosphate %3D D-ribulose 5-phosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_625 ZOBELLIA_626 ZOBELLIA_626 ZOBELLIA_626 763010 763711 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the cytoplasmic and/or outer membrane%3B~Conserved hypothetical protein gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_626 ZOBELLIA_627 ZOBELLIA_627 ZOBELLIA_627 763756 764025 - Conserved hypothetical protein Localized in the cytoplasm. gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_627 ZOBELLIA_628 ZOBELLIA_628 pmiA pmiA 764108 765070 - Mannose-6-phosphate isomerase%2C type I Mannose-6-phosphate isomerase or phosphomannose isomerase (PMI) is the enzyme that converts the mannose-6-phosphate to fructose-6-phosphate. Contains a phosphomannose isomerase type I domain%3B Binds 1 zinc ion per subunit%3B Belongs to the the cupin superfamily%2C mannose-6-phosphate isomerase type 1 family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_628 ZOBELLIA_629 ZOBELLIA_629 pts pts 765103 765510 - 6-Pyruvoyl tetrahydrobiopterin synthase 6-Pyruvoyl tetrahydrobiopterin synthase is involved in the biosynthesis of tetrahydrobiopterin%2C an essential cofactor of aromatic amino acid hydroxylases. It catalyzes the transformation of 7%2C8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. It forms a homohexamer formed of two homotrimers in a head to head fashion. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_629 ZOBELLIA_63 ZOBELLIA_63 ZOBELLIA_63 63807 64172 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_63 ZOBELLIA_630 ZOBELLIA_630 idiA idiA 765494 766213 - Isopentenyl-diphosphate Delta-isomerase Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1%2C3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer%2C dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_630 ZOBELLIA_631 ZOBELLIA_631 ZOBELLIA_631 766228 772563 - Thrombospondin type 3 repeats protein The presence of two EF-hand calcium-binding domains%2C four putatif thrombospondin type 3 repeats and one calx-beta motif suggest that this sequence is a calcium binding protein. The calx-beta motif is present in the cytoplasmic domains of Calx Na-Ca exchangers%3B Contains a Galactose-binding domain%3B Signal peptide cleaved between the residues 34 and 35%3B Putatively localized in the outer membrane%3B~Conserved hypothetical protein gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_631 ZOBELLIA_632 ZOBELLIA_632 ZOBELLIA_632 772625 773575 - Conserved hypothetical protein Contains a signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_632 ZOBELLIA_633 ZOBELLIA_633 ZOBELLIA_633 773584 775572 - Thrombospondin type 3 repeats protein Conserved protein containing five thrombospondin type 3 repeats (TSP3). TSP3 are calcium binding domains%3B Features an uncleaved signal peptide%3B Localized in the cytoplasmic meembrane%3B~Conserved hypothetical protein gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_633 ZOBELLIA_634 ZOBELLIA_634 ZOBELLIA_634 775633 783720 - Conserved hypothetical protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_634 ZOBELLIA_635 ZOBELLIA_635 ZOBELLIA_635 784125 784238 - Putative protein Hypothetical protein gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_635 ZOBELLIA_636 ZOBELLIA_636 ZOBELLIA_636 784287 788786 - Conserved beta helix fold protein Conserved protein containing two N-terminal Calx-beta motifs separated by a CUB domain and followed by a C-terminal beta helix fold domain of unknown function. Calx-beta motifs are involved in calcium-binding. CUB domains contain four conserved cysteines which probably form two disulfide bridges. The structure of the CUB domain has been predicted to be a beta-barrel%3B~Conserved hypothetical protein gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_636 ZOBELLIA_637 ZOBELLIA_637 ZOBELLIA_637 788947 789039 + Putative protein Hypothetical protein gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_637 ZOBELLIA_638 ZOBELLIA_638 ZOBELLIA_638 789071 791011 - OmpA-like outer membrane protein This protein has a modular architecture with two N-terminal TPR repeats%2C a central beta-propeller domain%2C encompassing five WD40 repeats%2C and a C-terminal OmpA domain. OmpA-like domain is thought to be responsible for non-covalent interactions with peptidoglycan. The tetratrico peptide repeat (TPR) is a structural motif%2C which mediates proteinprotein interactions. Signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane%3B~Function unclear gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_638 ZOBELLIA_639 ZOBELLIA_639 ZOBELLIA_639 791024 791983 - Conserved hypothetical protein Contains a signal peptide cleaved between the residues 29 and 30%3B Localized in the periplasmic space gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_639 ZOBELLIA_64 ZOBELLIA_64 ZOBELLIA_64 64172 64717 + Acyl-CoA thioesterase Acyl-CoA thioesterase hydrolyzes fatty acyl-CoA substrates releasing acyl-Coa and fatty acids. Localized in the cytoplasm.%3B~Specificity unclear gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_64 ZOBELLIA_640 ZOBELLIA_640 ZOBELLIA_640 791998 795777 - Hypothetical membrane protein Proteins that probably binds the calcium ions%3B Contains fifteen type-3 thrombospondin repeats%3B signal peptide cleaved between the residues 33 and 34%3B probably localized in the outer membrane%3B~Hypothetical protein gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_640 ZOBELLIA_641 ZOBELLIA_641 prfC prfC 796177 797766 + peptide chain release factor RF-3 The release factor 3 (RF-3)%2C a class II RF%2C is a translation termination factor that increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP%2C but not by GMP%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_641 ZOBELLIA_642 ZOBELLIA_642 ZOBELLIA_642 797824 798135 - Conserved hypothetical protein Protein localized in the cytoplasm gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_642 ZOBELLIA_643 ZOBELLIA_643 rpoC rpoC 798189 802487 - DNA-dependent RNA polymerase%2C beta subunit The beta subunit of RNA polymerase%2C in association with the beta and omega subunits and the two alpha subunits%2C forms the polymerase core. Within the polymerase core%2C the beta subunit binds to the DNA (non specifically)%3B The beta' subunit contains five domains. The protein contains the domains 1%2C 2%2C 3%2C 4 and 5 that represent the clamp domain%2C the binding site of magnesium ion%2C the pore domain%2C the funnel domain and the discontinuous cleft domain that is required to form the central channel where the DNA is bound respectively%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_643 ZOBELLIA_644 ZOBELLIA_644 rpoB rpoB 802542 806351 - DNA-dependent RNA polymerase%2C beta subunit The beta subunit of RNA polymerase%2C in association with the beta subunit%2C omega subunit and the two alpha subunits%2C forms the polymerase core. The beta subunit possesses the polymerase activity%3B It contains seven domains. The domains 1 and 2 form the two distinctive lobes of the protein%2C the domain 3 or fork domain is proximal to catalytic site%2C the domain 6 is the heteroduplex binding domain and the domain 7 or clamp region has a zinc-binding motif and interacts with the clamp domain found in the beta' subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_644 ZOBELLIA_645 ZOBELLIA_645 rplL rplL 806496 806873 - Ribosomal protein L7/L12 Ribosomal protein L7/L12 are two proteins from the large ribosomal subunit (50S) present in four copies organized as two dimers. The L7/L12 dimer probably interacts with EF-Tu. L7 and L12 only differ in a single post translational modification of the addition an acetyl group to the N terminus of L7%3B The N-terminal domain of L7/12 is required for dimer formation and for binding to ribosomal protein L10 to form a very strong complex called L8. The C-terminal domain of L7/12 is required for translation factors binding%3B Belongs to the ribosomal protein L12b/L12e family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_645 ZOBELLIA_646 ZOBELLIA_646 rplJ rplJ 806927 807442 - Ribosomal protein L10 Ribosomal protein L10 is one of the proteins from the large ribosomal subunit (50S). With a dimer of ribosomal proteins L7/12%2C it forms the L8 complex. Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA%3B Belongs to the ribosomal proteins L10p/L10e family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_646 ZOBELLIA_647 ZOBELLIA_647 rplA rplA 807471 808160 - Ribosomal protein L1 Ribosomal protein L1 is the largest protein from the large ribosomal subunit (50S)%2C known to bind very close to the 3' end of the 23S rRNA%3B Forms part of the L1 stalk%3B The ribosmal protein L1 is located in the neighborhood of the site where elongation factor Tu is bound to the ribosome%3B The ribosomal protein L1 is also a translational repressor protein of the L11 operon by binding to its mRNA%3B Belongs to the ribosomal L1p/L10Ae family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_647 ZOBELLIA_648 ZOBELLIA_648 rplK rplK 808181 808618 - Ribosomal protein L11 Ribosomal protein L11 is one of the proteins from the large ribosomal subunit (50S)%2C known to bind directly to the 23S rRNA%3B Forms the L11 stalk%2C which is mobile in the ribosome%2C indicating its contribution to the activity of initiation%2C elongation and release factors%3B The N-terminal domain of ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain%3B Belongs to the ribosomal proteins family L11p/L12e%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_648 ZOBELLIA_649 ZOBELLIA_649 nusG nusG 808686 809237 - Transcription antitermination protein The transcription anti-termination protein influences transcription termination and anti-termination. It is a transcriptional elongation factor of the transcription complex that interacts with the termination factor rho and RNA polymerase%3B Contains a C-terminal KOW (Kyrpides%2C Ouzounis%2C Woese) motif involved in the nucleic acid interaction%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_649 ZOBELLIA_65 ZOBELLIA_65 pglA pglA 64710 65423 - 6-Phosphogluconolactonase 6-Phosphogluconolactonase is the enzyme responsible for the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate%2C the second step of the oxidative phase of the pentose phosphate pathway%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_65 ZOBELLIA_651 ZOBELLIA_651 tufA tufA 809599 810786 - Translation elongation factor Tu EF-Tu binds GTP and an aminoacyl-tRNA and delivers the latter to the A-site of ribosomes during protein biosynthesis. Its GTPase activity is stimulated by recognition of the mRNA codon by the aminoacyl-tRNA anticodon%3B EF-Tu consists of three structural domains: the N-terminal domain binds the GTP%2C the second domain is involved in binding to charged tRNA and the C-terminal domain is involved in binding to both charged tRNA and binding to EF-Ts%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_651 ZOBELLIA_656 ZOBELLIA_656 rpoX rpoX 811401 811703 - Sigma-54 modulation protein Probably modulates the activity of sigma-54 factor%3B Belongs to the sigma-54 modulation protein/ribosomal protein S30EA family%3B Localized in the cytoplasm%3B~Function unclear gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_656 ZOBELLIA_657 ZOBELLIA_657 xerC xerC 811743 812633 - Tyrosine recombinase XerC Tyrosine recombinase XerC acts by catalyzing the cutting and rejoining of the recombining DNA molecules utilizing a catalytic tyrosine for the strand cleavage%3B Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites%3B Belongs to the \\phage\\ integrase family%2C XerD and XerC integrases subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_657 ZOBELLIA_658 ZOBELLIA_658 ZOBELLIA_658 813095 814264 - Acyl-CoA dehydrogenase Acyl-CoA dehydrogenases catalyze the alpha%2Cbeta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2%2C3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. Reoxidation of the flavin involves transfer of electrons to ETF (electron transfering flavoprotein). These enzymes are homodimers containing one molecule of FAD%3B Localized in the cytoplasm%3B~Specificity unclear gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_658 ZOBELLIA_659 ZOBELLIA_659 ZOBELLIA_659 814276 815166 - Conserved hypothetical membrane protein Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_659 ZOBELLIA_66 ZOBELLIA_66 zwfA zwfA 65479 67011 - Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate 1-dehydrogenase catalyses the first step of the oxidative phase of the pentose pathway. It converts the glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP%2C producing NADPH%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_66 ZOBELLIA_660 ZOBELLIA_660 ZOBELLIA_660 815181 817250 - Sodium / alanine symporter This permease transports alanine in association with sodium ions. It forms a channel through the cytoplasmic membrane%2C the interior face being hydrophilic to allow the passage of alanine molecules and sodium ions. Features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_660 ZOBELLIA_661 ZOBELLIA_661 mthK mthK 817362 818375 - Calcium-gated potassium channel This channel transports potassium ion in response to intracellular calcium ion binding. Eight RCK domains (regulators of K+ conductance) form a gating ring at the intracellular membrane surface. The gating ring uses the free energy of Ca2+ binding in a simple manner to perform mechanical work to open the pore. This channel is a homotetramer and the monomer subunit features three transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_661 ZOBELLIA_662 ZOBELLIA_662 ZOBELLIA_662 818372 818599 - Conserved hypothetical membrane protein Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_662 ZOBELLIA_663 ZOBELLIA_663 ZOBELLIA_663 818673 819986 - Conserved hypothetical protein Localized in the cytoplasm. gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_663 ZOBELLIA_664 ZOBELLIA_664 glpE1 glpE1 820115 820426 - Thiosulfate sulfurtransferase Thiosulfate sulfurtransferase catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate%3B Contains one only rhodanese domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_664 ZOBELLIA_665 ZOBELLIA_665 ZOBELLIA_665 820588 821034 + MarR-type transcriptional regulator The transcriptional regulators with the marR-type HTH domain control a variety of biological functions%2C including resistance to multiple antibiotics%2C household disinfectants%2C organic solvents%2C oxidative stress agents. Many of the marR-like regulators respond to aromatic compounds%3B Contains a DNA-binding%2C winged helix-turn-helix (wHTH) domain%3B Localized in the cytoplasm%3B~Family membership gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_665 ZOBELLIA_666 ZOBELLIA_666 ZOBELLIA_666 821076 821651 + Conserved hypothetical protein Conserved hypothetical protein that belongts to the YceI like family%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_666 ZOBELLIA_667 ZOBELLIA_667 trpE trpE 821890 823287 + Anthranilate synthase%2C component I The anthranilate synthase catalyzes the formation of anthranilate from chorismate and L-glutamine%2C the first step in the biosynthesis of tryptophan. The enzyme is a Tetramer of two components I and two components II. The component I only catalyzes the formation of anthranilate using chorismate and ammonia rather than glutamine%3B The anthranilate synthase is regulated by feedback inhibition by tryptophan%3B Belongs to the anthranilate synthase component I family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_667 ZOBELLIA_668 ZOBELLIA_668 trpG trpG 823290 823853 + Anthranilate synthase component II (glutamine amidotransferase) The anthranilate synthase catalyzes the formation of anthranilate from chorismate and L-glutamine%2C the first step in the biosynthesis of tryptophan. The enzyme is a Tetramer of two components I and two components II. Associated with the component I%2C the component II of the anthranilate synthase provides the glutamine amidotransferase activity (GATase%2C 2.4.2.-) that catalyses the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate%2C thus creating a new carbon-nitrogen group on the substrate%3B Consists of a type-1 glutamine amidotransferase domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_668 ZOBELLIA_669 ZOBELLIA_669 trpD trpD 823911 824906 + Anthranilate phosphoribosyltransferase This enzyme is a part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan from chorismate. It catalyses the formation of N-(5-phospho-D-ribosyl)-anthranilate from anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate%2C the second step in the biosynthesis of tryptophan%3B Belongs to the anthranilate phosphoribosyltransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_669 ZOBELLIA_67 ZOBELLIA_67 gndA gndA 67184 68596 + 6-Phosphogluconate dehydrogenase%2C decarboxylating 6-Phosphogluconate dehydrogenase catalyzes the decarboxylating reduction of 6-phosphogluconate to ribulose 5-phosphate in the presence of NADP. This step is the last reaction of the oxidative phase of the pentose phosphate pathways (hexose mono-phosphate shunt)%3B Forms a homodimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_67 ZOBELLIA_670 ZOBELLIA_670 trpC trpC 824932 825714 + Indole-3-glycerol phosphate synthase Indole-3-glycerol phosphate synthase (IGPS) catalyzes the ring closure of 1-(2-carboxy-phenylamino)-1-deoxyribulose into indol-3-glycerol-phosphate%2C the fourth step in the biosynthesis of tryptophan%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_670 ZOBELLIA_671 ZOBELLIA_671 trpF trpF 825715 826419 + N-(5'-phosphoribosyl)anthranilate isomerase The N-(5'-phosphoribosyl)anthranilate isomerase (PRAI) converts the N-(5-phospho-beta-D-ribosyl)anthranilate to 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate%2C the third step in the biosynthesis of tryptophan%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_671 ZOBELLIA_672 ZOBELLIA_672 trpB1 trpB1 826479 827663 + Tryptophan synthase beta subunit The tryptophan synthase catalyzes the fifth and the last step in the biosynthesis of tryptophan. It is a tetramer of two alpha and two beta chains. The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine%3B Uses the pyridoxal phosphate (vitamin B6) as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_672 ZOBELLIA_673 ZOBELLIA_673 trpA trpA 827755 828519 + Tryptophan synthase%2C alpha subunit The tryptophan synthase catalyzes the fifth and the last step in the biosynthesis of tryptophan. It is a tetramer of two alpha and two beta chains. The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate%3B Uses the pyridoxal phosphate (vitamin B6) as cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_673 ZOBELLIA_674 ZOBELLIA_674 ZOBELLIA_674 828545 828772 + Conserved hypothetical membrane protein Contains two transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_674 ZOBELLIA_675 ZOBELLIA_675 ZOBELLIA_675 828820 829791 + Conserved hypothetical protein Seems to possess a signal peptide possibly cleaved between the residues 18 and 19%3B Could be localized in the periplasmic space gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_675 ZOBELLIA_676 ZOBELLIA_676 ppcA ppcA 829862 832408 - Phosphoenolpyruvate carboxylase Phosphoenolpyruvate carboxylase supplies oxaloacetate to the tricarboxylic acid cycle%2C which requires continuous input of C4 molecules in order to replenish the intermediates removed for amino acid biosynthesis. It forms an homotetramer%3B Belongs to the PEPCase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_676 ZOBELLIA_677 ZOBELLIA_677 ZOBELLIA_677 832714 833379 - Conserved hypothetical protein Localized in the cytoplasm gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_677 ZOBELLIA_678 ZOBELLIA_678 pycA pycA 833395 836847 - Pyruvate carboxylase Pyruvate carboxylase catalyzes a 2-step reaction%2C involving%2C in the first step%2C the ATP-dependent carboxylation of the covalently attached biotin and%2C in the second%2C the transfer of the carboxyl group to pyruvate. PycA has three functional domains: a biotin carboxylase (BC) domain%2C a carboxyltransferase (CT) domain which perform the second part of the reaction and a biotinyl domain%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_678 ZOBELLIA_679 ZOBELLIA_679 ZOBELLIA_679 837045 837173 + Conserved hypothetical protein Contains%2C in its N-terminal part%2C a domain Localized in the cytoplasm gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_679 ZOBELLIA_68 ZOBELLIA_68 ZOBELLIA_68 68646 69212 + Conserved hypothetical protein Contains one N-terminal transmembrane segment%3B Probably localized in the cytoplasmic membrane gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_68 ZOBELLIA_680 ZOBELLIA_680 ZOBELLIA_680 837175 837936 - Conserved hypothetical protein Protein containing a DUF328 domain%3B Belongs to the UPF0246 family%3B Localized in the cytoplasm gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_680 ZOBELLIA_681 ZOBELLIA_681 rluD rluD 838042 839070 - Ribosomal large subunit pseudouridine synthase D Enzyme responsible for synthesis of pseudouridine from uracil at positions 1911%2C 1915 and 1917 in 23S ribosomal RNA by rotation of the C1'-N-1 glycosidic bond of uridine to a C1'-C5%3B Contains a N-terminal S4 RNA- binding domain that probably mediates binding to RNA%3B Belongs to the pseudouridine synthase RluA family%3B localized in the cytoplasm%3B~High confidence in function and specificity gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_681 ZOBELLIA_682 ZOBELLIA_682 ZOBELLIA_682 839074 839661 - PASTA domain protein Conserved protein containing two PASTA domains (Pbp And Serine/Threonine kinase Associated domains). Such domains bind the beta-lactam stem%2C which implicates it in sensing D-alanyl-D-alanine. PASTA domain adopts a small globular fold consisting of 3 beta-sheets and an alpha-helix%3B Contains a N-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_682 ZOBELLIA_683 ZOBELLIA_683 ddlA ddlA 839755 840735 + D-alanine--D-alanine ligase D-alanine-D-alanine ligase is one of the central enzyme of the cross-linking step of peptidoglycan assembly. It catalyzes the reaction: ATP + 2 D-alanine %3D ADP + phosphate + D-alanyl-D-alanine. Uses ATP as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_683 ZOBELLIA_684 ZOBELLIA_684 coaD coaD 840780 841235 + Phosphopantetheine adenylyltransferase Phosphopantetheine adenylyltransferase is involved in the biosynthesis of coenzyme A from pantothenate. It reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine%2C yielding dephospho-CoA and pyrophosphate. It forms a homohexamer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_684 ZOBELLIA_685 ZOBELLIA_685 ZOBELLIA_685 841442 843292 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains one N-terminal PAS/PAC domain involved in many signalling proteins where they are used as a signal sensor domain%3B Seems localized in the cytoplasm%3B~Family membership gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_685 ZOBELLIA_686 ZOBELLIA_686 ZOBELLIA_686 843279 843683 + Two-component system-Response regulator%2C receiver domain The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually%2C the protein consists of an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA-binding activity that acts as transcriptional regulator. This sequence corresponds to the receiver domain only%3B~Family membership gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_686 ZOBELLIA_687 ZOBELLIA_687 ZOBELLIA_687 843718 845493 + Metallopeptidase%2C family M14 Metallocarboxypeptidases remove aminoacid residues from the C-terminal end of proteins. The single catalytic zinc ion is tetrahedrally coordinated by two histidines and a glutamate%2C as well as a water molecule. One of the histidines and the glutamate occur in the motif His-Xaa-Xaa-Glu%3B Belongs to the family M14 of peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 22 and 23%3B Localized in the outer membrane%3B~Specificity unclear gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_687 ZOBELLIA_688 ZOBELLIA_688 ZOBELLIA_688 845499 846086 - NUDIX hydrolase This conserved protein belongs to the Nudix (NUcleoside DIphosphate linked to some other moiety X) hydrolase family. Its specificity is unclear%3B Localized in the cytoplasm%3B~Family membership gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_688 ZOBELLIA_689 ZOBELLIA_689 pyrE pyrE 846094 846735 + Orotate phosphoribosyltransferase Orotate phosphoribosyltransferase is involved in pyrimidine biosynthesis. It catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribosyl-1-pyrophosphate to orotate%2C leading to the formation of orotidine monophosphate. It forms a homodimer and binds one magnesium ion per subunit as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_689 ZOBELLIA_69 ZOBELLIA_69 ZOBELLIA_69 69358 71589 + Two-component system hybrid-Sensor histidine kinase/Response regulator%2C receiver domain The sensor histidine kinase belongs to two-component signal transduction systems. The cytoplasmic part of the protein consists of the histidine kinase domain and of the receiver domain of the response regulator that is phosphorylated by the histidine kinase domain. A transmembrane segment separates this part from the periplasmic part that contains three tetratrico peptide repeats%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_69 ZOBELLIA_690 ZOBELLIA_690 ZOBELLIA_690 846743 847135 + Conserved hypothetical protein Localized in the cytoplasm gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_690 ZOBELLIA_691 ZOBELLIA_691 ZOBELLIA_691 847136 847867 - Biotin-[acetyl-CoA-carboxylase] ligase Biotin-[acetyl-CoA-carboxylase]ligase is responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. These enzymes usually transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_691 ZOBELLIA_692 ZOBELLIA_692 ZOBELLIA_692 847960 848343 + Iojap family protein Conserved protein belonging to the Iojap family. In maize%2C iojap is a pattern-striping gene%2C reflecting a chloroplast development defect in some cells. The role of iojap in chloroplast development%2C and the role of its bacterial orthologs%2C is unclear%3B Localized in the cytoplasm%3B~Family membership gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_692 ZOBELLIA_693 ZOBELLIA_693 ftsH ftsH 848353 850362 + Cell division protein FtsH FtsH is a membrane-anchored ATP-dependent metalloprotease involved in membrane functions%2C cell cycle control%2C and gene expression. It only efficiently degrades misfolded or misassembled membrane proteins as well as a subset of cytoplasmic regulatory proteins (as the heat-shock transcription factor sigma 32) that have a low thermodynamic stability. it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded%3B Binds 1 zinc ion%3B Contains two N-terminal transmembrane segments%3B belongs%2C in the N-terminal part%2C to the AAA ATPase family and%2C in the C-terminal part%2C to the peptidase M41 family (clan (MA(E))%3B Localized in the cytpolasmic membrane%3B~High confidence in function and specificity gene gene693 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_693 ZOBELLIA_694 ZOBELLIA_694 ZOBELLIA_694 850421 851035 + Conserved hypothetical protein Localized in the cytoplasm gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_694 ZOBELLIA_695 ZOBELLIA_695 cdsA cdsA 851037 851840 + Phosphatidate cytidylyltransferase Phosphatidate cytidylyltransferase is essential for phospholipid biosynthesis. It catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate: CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. Features seven transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_695 ZOBELLIA_696 ZOBELLIA_696 psd psd 851830 852513 + Phosphatidylserine decarboxylase proenzyme Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine. It uses a pyruvate group as cofactor. Two nonidentical subunits of the mature enzyme are formed by cleavage of the proenzyme resulting in the conversion of the catalytic Serine to an amino-terminal pyruvate residue. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_696 ZOBELLIA_697 ZOBELLIA_697 ZOBELLIA_697 852488 852754 + Acyl-CoA binding protein Acyl-CoA binding protein (ACBP) is a small (~~10 kDa) protein that binds medium- and long-chain acyl-CoA esters with high affinity%2C and may act as an intra- cellular carrier of acyl-CoA esters. It is a mainly-alpha protein%2C consisting of 5 short alpha-helices and 3 connecting beta-strands. Localized in the cytoplasm.%3B~Family membership gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_697 ZOBELLIA_698 ZOBELLIA_698 ZOBELLIA_698 852787 853551 - Creatinase family protein Conserved protein belonging to the creatinase family%2C but its exact function is unclear%3B Localized in the cytoplasm%3B~Family membership gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_698 ZOBELLIA_699 ZOBELLIA_699 ZOBELLIA_699 853589 854857 - Fatty acid hydroxylase family protein Conserved protein belonging to the Fatty acid hydroxylase family which includes fatty acid and carotene hydroxylases and sterol desaturases%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_699 ZOBELLIA_7 ZOBELLIA_7 dapF dapF 5979 6707 - Diaminopimelate epimerase The diaminopimelate epimerase catalyses the isomerisation of L%2CL-dimaminopimelate to meso-DAP in the biosynthetic pathway leading from aspartate to lysine%3B The meso-DAP is subsequently converted to lysine by a decarboxylase%2C or%2C in Gram-negative bacteria%2C assimilated into the cell wall%3B Enzyme consists of two domains of the same alpha/beta fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_7 ZOBELLIA_70 ZOBELLIA_70 ZOBELLIA_70 71603 71953 + Conserved hypothetical protein gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_70 ZOBELLIA_700 ZOBELLIA_700 ZOBELLIA_700 854907 855500 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 16 and 17%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_700 ZOBELLIA_701 ZOBELLIA_701 ZOBELLIA_701 855796 856365 - TetR-type transcriptional regulator Several of these transcriptional regulators are repressors of genes and operons for membrane transport and cell envelope permeability%3B The helix-turn-helix motif is located in the initial third of the protein. The C-terminal part contains regions that can be involved in binding of inducers%2C which can be drugs%2C and oligomerization%3B Localized in the cytoplasm%3B~Family membership gene gene701 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_701 ZOBELLIA_702 ZOBELLIA_702 valS valS 856596 859226 - Valyl-tRNA synthetase Valyl-tRNA synthetase catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine%2C to avoid such errors%2C it has a \\posttransfer\\ editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Belongs to the class-I aminoacyl-tRNA synthetase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_702 ZOBELLIA_703 ZOBELLIA_703 ZOBELLIA_703 859426 859800 + Conserved hypothetical protein Conserved protein belonging to the DUF1573 family%2C which includes proteins of unknown function conserved in bacteria such as Rhodopirellula baltica%2C Bacteroides thetaiotaomicron%2C and Porphyromonas gingivalis%3B Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_703 ZOBELLIA_704 ZOBELLIA_704 ZOBELLIA_704 859862 861193 - Conserved PDZ-containing protein Conserved protein containing a N-terminal domain of unknonwn function and a C-terminal PDZ domain. PDZ domains bind either the carboxyl-terminal sequences of proteins or internal peptide sequences%3B Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_704 ZOBELLIA_705 ZOBELLIA_705 aatB aatB 861279 862526 + Aspartate aminotransferase Aspartate aminotransferase or Transaminase A or Glutamic-aspartic transaminase or Glutamic-oxaloacetic transaminase converts the L-aspartic acid and the 2-oxoglutarate into L-glutamate and oxaloacetate using the Pyridoxal phosphate as cofactor bound by covalent linkage to a lysine residue%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_705 ZOBELLIA_706 ZOBELLIA_706 murB murB 862526 863542 + UDP-N-acetylenolpyruvoylglucosamine reductase Cytoplasmic protein also called UDP-N-acetylmuramate dehydrogenase%3B Uses the FAD as cofactor%3B This enzyme participates to the cell wall formation as a part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide%2C which is a precursor of bacterial peptidoglycan.%3B~High confidence in function and specificity gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_706 ZOBELLIA_707 ZOBELLIA_707 ZOBELLIA_707 863746 864312 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_707 ZOBELLIA_708 ZOBELLIA_708 ZOBELLIA_708 864317 865075 + Conserved hypothetical membrane protein Contains one transmembrane segment%3B Probably localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_708 ZOBELLIA_709 ZOBELLIA_709 ZOBELLIA_709 865161 865379 + Putative exported protein Signal peptide putatively cleaved between the residues 19 and 20%3B Probably localized in the periplasmic space%3B~Hypothetical protein gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_709 ZOBELLIA_71 ZOBELLIA_71 alkK alkK 72037 73662 + Medium-chain-fatty-acid-CoA ligase AlkK is involved in alkane catabolism. It catalyzes the reaction: ATP + a medium-chain carboxylic acid + CoA %3D AMP + diphosphate + an acyl-CoA. It uses ATP as cofactor%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_71 ZOBELLIA_710 ZOBELLIA_710 ZOBELLIA_710 865405 865959 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_710 ZOBELLIA_711 ZOBELLIA_711 lipA lipA 866081 866956 + Lipoyl synthase Catalyzes the radical-mediated insertion of two sulfur atoms into an octanoyl group bound to acyl carrier protein (ACP) to produce a lipoyl group%3B Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Also binds 1 3Fe-4S cluster%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_711 ZOBELLIA_712 ZOBELLIA_712 gapC gapC 867051 868061 + Glyceraldehyde 3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the sixth step of glycolysis (Embden-Meyerhof pathway) and thus serves to break down glucose for energy and carbon molecules by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3- phosphate to 1%2C3-diphospho-glycerate. Also it plays an important role in gluconeogenesis%3B Acts as an homotetramer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_712 ZOBELLIA_713 ZOBELLIA_713 ZOBELLIA_713 868058 870286 + Two-component system hybrid-Sensor histidine kinase/Response regulator%2C receiver domain The sensor histidine kinase belongs to two-component signal transduction systems. The cytoplasmic part of the protein consists of the histidine kinase domain and of the receiver domain of the response regulator that is phosphorylated by the histidine kinase domain. A transmembrane segment separates this part from the periplasmic part that contains three tetratrico peptide repeats%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_713 ZOBELLIA_714 ZOBELLIA_714 lpxK lpxK 870279 871274 - Tetraacyldisaccharide 4'-kinase Tetraacyldisaccharide 4'-kinase is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharides. It transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1%2C4'-bis-phosphate (lipid IVA). Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_714 ZOBELLIA_715 ZOBELLIA_715 ZOBELLIA_715 871323 872417 + NIF3 family protein Conserved protein belonging to the NIF3 family. NIF3 is a yeast protein interacting with the transcriptional coactivator NGG1p which is part of the ADA complex. The exact function of this interaction is unknown%3B Localized in the cytoplasm%3B~Family membership gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_715 ZOBELLIA_716 ZOBELLIA_716 ZOBELLIA_716 872423 873202 + Conserved hypothetical protein Localized in the cytoplasm. gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_716 ZOBELLIA_717 ZOBELLIA_717 kmoA kmoA 873269 874609 - Kynurenine 3-monooxygenase Kynurenine 3-monooxygenase plays a key role in the catabolism of tryptophan by catalyzing the hydroxylation of Kynurenine to 3-hydroxykynurenine%3B This enzyme is NADPH-dependent%2C uses the FAD as cofactor and adopts a Rossmann fold%3B Contains one N-terminal transmembrane segment%3B Belongs to the aromatic-ring hydroxylase family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_717 ZOBELLIA_718 ZOBELLIA_718 clpP2 clpP2 874936 875565 - Endopeptidase Clp%2C peptidase subunit%2C family S14 Endopeptidase Clp plays a major role in the degradation of misfolded proteins. It is an oligomeric complex constituted by an ATP-binding subunit (ClpX) and a peptidase subunit (ClpP). The subunits form two different ring structures consisting of seven peptidase subunits and six ATP-binding subunits%2C respectively. In absence of ClpX%2C ClpP can act only on oligopeptides%3B Belongs to the family S14 of the peptidases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_718 ZOBELLIA_719 ZOBELLIA_719 ZOBELLIA_719 875676 876374 + Conserved hypothetical membrane protein Contains a putative lipoprotein signal peptide cleaved between the residues 23 and 24%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_719 ZOBELLIA_72 ZOBELLIA_72 carB carB 73720 76575 - Carbamoyl-phosphate synthase large chain Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. It is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia%2C which is used by the large chain to synthesize carbamoyl phosphate. Binds three magnesium ion as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_72 ZOBELLIA_720 ZOBELLIA_720 ZOBELLIA_720 876387 877532 - Major facilitator family transporter The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. Features twelve transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_720 ZOBELLIA_721 ZOBELLIA_721 ZOBELLIA_721 877671 878747 - Flavastacin%2C family M12 Flavastacin is a zinc metallendopeptidase that hydrolyzes polypeptides on the amino-side of Asp in -Xaa-|-Asp-. Acts very slowly on -Xaa-|-Glu. Displays a o-glycosylation consisting of a Man%2C GlcNAc%2C GlcU%2C Glc%2C GlcU%2C Rha%2C Man heptasaccharide%3B Belongs to the family M12 of the peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 32 and 33%3B Localized in the outer membrane%3B~High confidence in function and specificity gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_721 ZOBELLIA_722 ZOBELLIA_722 kynU kynU 878924 880195 - Kynureninase Kynureninase%2C involved in the catabolism of L-tryptophan%2C converts the L-kynurenine to anthranilate and L-alanine%3B Uses pyridoxal-5'-phosphate as cofactor%3B Belongs to the PLP dependent aminotransferase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene722 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_722 ZOBELLIA_723 ZOBELLIA_723 ZOBELLIA_723 880245 880712 - GCN5-related N-acetyltransferase The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule%3B Belongs to Gcn5 or GNAT actyltransferase family%3B Localized in the cytoplasm%3B~Family membership gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_723 ZOBELLIA_724 ZOBELLIA_724 mdmC mdmC 880781 881422 + O-methyltransferase MdmC is a 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_724 ZOBELLIA_725 ZOBELLIA_725 sepP1 sepP1 881388 881960 - Undecaprenyl-diphosphatase Undecaprenyl-diphosphatase catalyzes the hydrolysis of dolichol pyrophosphate%2C likely in connection with glycosylation reactions of membrane. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_725 ZOBELLIA_726 ZOBELLIA_726 tatA tatA 881963 882301 - Sec-independent protein translocase TatA is involved in a sec-independent translocation mechanism%2C termed TAT for twin-arginine translocation system. This system mainly transports proteins with bound cofactors that require folding prior to export. TatA is required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K%3B Belongs to the mttA/Hcf106 family%3B Contains a transmembrane helix%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_726 ZOBELLIA_727 ZOBELLIA_727 ZOBELLIA_727 882384 884696 - Aminopeptidase%2C family M1 Aminopeptidase catalyzes the hydrolysis of N-terminal amino-acid residues from oligopeptides or polypeptides. This enzyme belongs to the family M1 of the peptidases. A catalytic zinc ion is bound by two histidines and a glutamate. The histidines are within an 'HEXXH' motif on one long helix with the glutamate on another antiparallel helix. The catalytic mechanism is believed to involve activation of a water molecule by the zinc ion. The glutamate of the HEXXH motif is known to be important for catalysis and a tyrosine may also be involved. Features a signal peptide cleaved between the residues 21 and 22. Localized in the periplasm.%3B~Specificity unclear gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_727 ZOBELLIA_728 ZOBELLIA_728 ZOBELLIA_728 884757 885263 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_728 ZOBELLIA_729 ZOBELLIA_729 ZOBELLIA_729 885314 886144 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene729 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_729 ZOBELLIA_73 ZOBELLIA_73 ZOBELLIA_73 77049 77954 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_73 ZOBELLIA_730 ZOBELLIA_730 ZOBELLIA_730 886197 887027 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene730 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_730 ZOBELLIA_731 ZOBELLIA_731 ZOBELLIA_731 887086 887868 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_731 ZOBELLIA_732 ZOBELLIA_732 ZOBELLIA_732 887855 888604 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_732 ZOBELLIA_733 ZOBELLIA_733 ZOBELLIA_733 888966 892508 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_733 ZOBELLIA_734 ZOBELLIA_734 ZOBELLIA_734 892533 893684 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_734 ZOBELLIA_735 ZOBELLIA_735 ZOBELLIA_735 894048 894782 + Metallopeptidase%2C family M15 Peptidase family M15 contains metallopeptidases%2C mostly D-ala-Dala carboxypeptidases and dipeptidases involved in peptidoglycan metabolism. These peptidases are zinc-dependent. This cation is bound by conserved residues%2C two hidistines and one aspartate. Features a twin-arginine signal peptide cleaved between the residues 26 and 27. Localized in the periplasm.%3B~Specificity unclear gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_735 ZOBELLIA_736 ZOBELLIA_736 ZOBELLIA_736 894820 895584 + Metallopeptidase%2C family M48 Peptidase family M48 contains metalloendopeptidases. The single catalytic zinc ion tetrahedrally is co-ordinated by two histidines within an HEXXH motif%2C an as yet undetermined third residue and water. The glutamate within the HEXXH motif is essential for catalysis. Features a signal peptide cleaved between the residues 20 and 21. Localized in the periplasm.%3B~Specificity unclear gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_736 ZOBELLIA_737 ZOBELLIA_737 ZOBELLIA_737 896097 896489 - Ankyrin repeats protein Conserved protein containing two ankyrin repeats. The ankyrin repeat is involved in protein-protein interaction. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure%3B Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_737 ZOBELLIA_738 ZOBELLIA_738 gpmI gpmI 896833 898350 + 2%2C3-Bisphosphoglycerate-independent phosphoglycerate mutase The 2%2C3-bisphosphoglycerate-dependent phosphoglycerate mutase (PGAM) catalyzes the step 8 of the glycolysis (Embden-Meyerhof pathway). PGAM catalyzes the internal transfer of a phosphate group from C-3 to C-2 which results in the conversion of 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG) through a 2%2C3-bisphosphoglycerate intermediate%3B Uses 2 manganese ions as cofactors%3B Belongs to the phosphoglycerate mutase family%2C BPG-dependent PGAM subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_738 ZOBELLIA_739 ZOBELLIA_739 mapA mapA 898384 899202 + Methionyl aminopeptidase%2C family M24 Methionyl aminopeptidase cleaves the Met-Xaa bond in the removal of the initiating N-terminal methionine from newly synthesized proteins. Belongs to the family M24 of the metallopeptidases. Requires two co-catalytic ions of cobalt. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_739 ZOBELLIA_74 ZOBELLIA_74 ZOBELLIA_74 77960 78475 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_74 ZOBELLIA_740 ZOBELLIA_740 ZOBELLIA_740 899245 900015 + Conserved hypothetical protein Localized in the cytoplasm. gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_740 ZOBELLIA_741 ZOBELLIA_741 apbE1 apbE1 900012 900956 - Thiamine biosynthesis protein apbE ApbE is involved in the conversion of aminoimidazole ribotide (AIR)%2C a purine intermediate%2C to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_741 ZOBELLIA_742 ZOBELLIA_742 ZOBELLIA_742 901012 901380 - Conserved hypothetical protein Localized in the cytoplasm gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_742 ZOBELLIA_743 ZOBELLIA_743 nqrF nqrF 901494 902801 - Na(+)-translocating NADH-quinone reductase subunit F NADH-quinone reductase (NQR) complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. This complex is composed of six subunits (nqrA%2C nqrB%2C nqrC%2C nqrD%2C nqrE and nqrF). The first step is catalyzed by nqrF%2C which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. NrqF binds one 2Fe-2S cluster and one FAD as cofactors. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_743 ZOBELLIA_744 ZOBELLIA_744 nqrE nqrE 902804 903556 - Na(+)-translocating NADH-quinone reductase subunit E ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. This complex is composed of six subunits (nqrA%2C nqrB%2C nqrC%2C nqrD%2C nqrE and nqrF). NqrA to nqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_744 ZOBELLIA_745 ZOBELLIA_745 nqrD nqrD 903578 904225 - Na(+)-translocating NADH-quinone reductase subunit D NADH-quinone reductase (NQR) complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. This complex is composed of six subunits (nqrA%2C nqrB%2C nqrC%2C nqrD%2C nqrE and nqrF). NqrA to nqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_745 ZOBELLIA_746 ZOBELLIA_746 nqrC nqrC 904227 904976 - Na(+)-translocating NADH-quinone reductase subunit C NADH-quinone reductase (NQR) complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. This complex is composed of six subunits (nqrA%2C nqrB%2C nqrC%2C nqrD%2C nqrE and nqrF). NqrA to nqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_746 ZOBELLIA_747 ZOBELLIA_747 nqrB nqrB 904979 906253 - Na(+)-translocating NADH-quinone reductase subunit B NADH-quinone reductase (NQR) complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. This complex is composed of six subunits (nqrA%2C nqrB%2C nqrC%2C nqrD%2C nqrE and nqrF). NqrA to nqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol. Features eight transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene747 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_747 ZOBELLIA_748 ZOBELLIA_748 nqrA nqrA 906257 907609 - Na(+)-translocating NADH-quinone reductase subunit A NADH-quinone reductase (NQR) complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. This complex is composed of six subunits (nqrA%2C nqrB%2C nqrC%2C nqrD%2C nqrE and nqrF). NqrA to nqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_748 ZOBELLIA_749 ZOBELLIA_749 ZOBELLIA_749 907762 909006 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene749 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_749 ZOBELLIA_75 ZOBELLIA_75 clsA1 clsA1 78520 80016 - Cardiolipin synthetase Cardiolipin synthetase is involved in phospholipids biosynthesis. It catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (diphosphatidylglycerol) and glycerol. Contains two N-terminal transmembrane helices%3B Belongs to the phospholipase D family%3B Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_75 ZOBELLIA_750 ZOBELLIA_750 ZOBELLIA_750 909043 910170 + Conserved hypothetical membrane protein Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene750 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_750 ZOBELLIA_751 ZOBELLIA_751 apaG apaG 910183 910569 + Protein ApaG The exact function of ApaG is still unknown. ApaG adopts a fibronectin type III (Fn3) fold%2C with seven antiparallel beta strands forming two beta sheets. In spite of the presence of a putative GXGXXG pyrophosphate binding motif ApaG does not bind ATP or GTP%2C in vitro. Considering its Fn3 fold%2C ApaG may be involved in protein- protein interactions. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene751 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_751 ZOBELLIA_752 ZOBELLIA_752 pruA pruA 910772 912400 + 1-pyrroline-5-carboxylate dehydrogenase 1-pyrroline-5-carboxylate dehydrogenase is involved in L-proline degradation. It catalyzes the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O %3D L-glutamate + NADH. Belongs to the aldehyde dehydrogenase family and uses NAD as cofactor. Localized in the cytoplasm%3B~High confidence in function and specificity gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_752 ZOBELLIA_753 ZOBELLIA_753 ZOBELLIA_753 912522 913034 + DinB family protein%2C exported DNA damage-inducible (din) genes are coordinately regulated and together compose a global regulatory network that has been termed the SOS-like or SOB regulon.%3B~Conserved hypothetical protein gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_753 ZOBELLIA_754 ZOBELLIA_754 rsmG rsmG 913579 914214 - Ribosomal RNA small subunit methyltransferase G RsmG%2C also called 16S rRNA 7-methylguanosine methyltransferase and also GidB (glucose-inhibited division protein)%2C is a S-adenosyl-L-methionine dependent methyltransferase that specifically methylates the N7 position of a guanosine in 16S rRNA. It is likely involved in the regulation of cell division%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_754 ZOBELLIA_755 ZOBELLIA_755 des6-1 des6-1 914322 915425 + Linoleoyl-CoA desaturase Linoleoyl-CoA desaturase%2C also known as delta 6-desaturase%2C is responsible for the conversion of linoleic acid (18:2) to gamma-linolenic acid (18:3 gamma). It uses iron ion as a cofactor. Features five transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_755 ZOBELLIA_756 ZOBELLIA_756 aatA aatA 915489 916700 + Aspartate aminotransferase Aspartate aminotransferase or Transaminase A or Glutamic-aspartic transaminase or Glutamic-oxaloacetic transaminase converts the L-aspartic acid and the 2-oxoglutarate into L-glutamate and oxaloacetate using the Pyridoxal phosphate as cofactor bound by covalent linkage to a lysine residue%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_756 ZOBELLIA_757 ZOBELLIA_757 ZOBELLIA_757 916786 918936 - Conserved hypothetical protein Localized in the cytoplasm gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_757 ZOBELLIA_758 ZOBELLIA_758 trkH trkH 919278 920735 - Trk system potassium uptake protein trkH TrkH is a low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity. Features ten transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_758 ZOBELLIA_759 ZOBELLIA_759 trkA trkA 920768 922117 - CAZ94825.1 TrkA is part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_759 ZOBELLIA_76 ZOBELLIA_76 ZOBELLIA_76 80115 81080 - Lytic murein transglycosylase%2C family GH23 Lytic murein transglycosylase catalyzes the cleavage of the beta-1%2C4-glycosidic bond between N- acetylmuramic acid and N-acetylglucosamine residues%2C thereby conserving the energy in a newly synthesized 1%2C6- anhydrobond in the muramic acid residue. It belongs to the family 23 of the glycoside hydrolases. May play a role in recycling of muropeptides during cell elongation and/or cell division. Features a signal peptide cleaved between the residues 23 and 24. Localized in the periplasm.%3B~Specificity unclear gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_76 ZOBELLIA_760 ZOBELLIA_760 menG/ubiE menG/ubiE 922331 923062 + Menaquinone/ubiquinone biosynthesis methyltransferase Methyltransferase that catalyses the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) in the eighth and last step of the menaquinone (vitamin K2) biosynthesis pathway from chorismate%3B Belongs to the methyltransferase superfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_760 ZOBELLIA_761 ZOBELLIA_761 porT porT 923138 923857 + PorT protein PorT is essential for the transport of some proteins across the outer membrane from the periplasm to the cell surface. %3B Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_761 ZOBELLIA_762 ZOBELLIA_762 ZOBELLIA_762 923865 924587 - tRNA/rRNA methyltransferase Catalyzes the site-specific methylation of the 2' hydroxy group of the ribose in rRNA or tRNA%2C using the S-AdoMet%3B Contains a N-terminal RNA 2'-O ribose methyltransferase substrate binding domain and a C-terminal catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold%3B Belongs to the RNA methyltransferase TrmH family%3B Localized in the cytoplasm%3B~Family membership gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_762 ZOBELLIA_763 ZOBELLIA_763 ZOBELLIA_763 924776 927388 + Bacterial surface antigen Conserved protein belonging to the bacterial surface antigen family%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26%3B Localized in the outer membrane%3B~Function unclear gene gene763 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_763 ZOBELLIA_764 ZOBELLIA_764 fbaA fbaA 927597 928664 + Fructose-bisphosphate aldolase%2C class II Fructose-bisphosphate aldolase catalyzes the fourth step of the glycolysis (Embden-Meyerhof pathway). It cleaves the hexose D-fructose 1%2C6-bisphosphate into two trioses sugars: the dihydroxyacetone phosphate (ketone) and the D-glyceraldehyde 3-phosphate (aldehyde)%3B Forms a homodimer and binds two zinc ions per subunit (one is catalytic and the other provides a structural contribution) as cofactor%3B Belongs to the class II of the fructose-bisphosphate aldolases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_764 ZOBELLIA_765 ZOBELLIA_765 accD accD 928692 929576 + Acetyl-coenzyme A carboxylase%2C carboxyl transferase subunit beta The carboxyl transferase subunit beta is a part of the Acetyl-coenzyme A carboxylase complex that catalyzes the first step in long-chain fatty acid biosynthesis. the complex is a heterohexamer of biotin carboxyl carrier protein (accB)%2C biotin carboxylase (accC) and two subunits each of carboxyl transferase subunit alpha (accA) and subunit beta . First%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_765 ZOBELLIA_766 ZOBELLIA_766 ZOBELLIA_766 929573 930058 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_766 ZOBELLIA_767 ZOBELLIA_767 rpsO rpsO 930165 930434 + Ribosomal protein S15 Ribosomal protein S15 is one of the primary rRNA binding proteins of the ribosomal small subunit (30S). It binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Forms a bridge to the 50S subunit in the 70S ribosome%2C contacting the 23S rRNA%3B Belongs to the ribosomal protein S15p family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_767 ZOBELLIA_768 ZOBELLIA_768 pnpA pnpA 930631 932853 + Polyribonucleotide nucleotidyltransferase Polyribonucleotide nucleotidyltransferase is involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction. It is also involved in the RNA degradosome%2C a multi-enzyme complex important in RNA processing and messenger RNA degradation. It forms a homotrimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_768 ZOBELLIA_769 ZOBELLIA_769 rpoD1 rpoD1 933017 933880 + RNA polymerase sigma factor rpoD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. RpoD is usually the primary sigma factor in bacteria. Belongs to the sigma-70 factor family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_769 ZOBELLIA_77 ZOBELLIA_77 ZOBELLIA_77 81272 81934 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_77 ZOBELLIA_770 ZOBELLIA_770 ZOBELLIA_770 934118 934360 + Conserved hypothetical protein Localized in the cytoplasm. gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_770 ZOBELLIA_771 ZOBELLIA_771 yibK yibK 934364 934813 + tRNA/rRNA 2O-methyltransferase YibK YibK methylates the 2' hydroxy group of ribose moieties in rRNA or tRNA. The catalytic domain adopts an alpha/beta knot fold and binds the S-adenosyl methionine cofactor. This domain is also involved in the dimer formation. Localized in the cytoplasm.%3B~Specificity unclear gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_771 ZOBELLIA_772 ZOBELLIA_772 add add 934943 935962 + Adenosine deaminase Adenosine deaminase catalyzes the hydrolytic deamination of adenosine into inosine. It is involved in purine ribonucleoside monophosphate biosynthesis. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_772 ZOBELLIA_773 ZOBELLIA_773 rpeA rpeA 936059 936739 + Ribulose-phosphate 3-epimerase Ribulose-phosphate 3-epimerase converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Pentose phosphate pathway%3B Adopts a a TIM barrel fold%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_773 ZOBELLIA_774 ZOBELLIA_774 ZOBELLIA_774 936718 937698 + Pyridine nucleotide-disulphide oxidoreductase The pyridine nucleotide-disulphide reductases (PNDR) are thioredoxin reductase-like protein with a active site that is a redox-active disulfide bond. It uses the FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step%2C the reduced disulphide reduces the substrate%3B Localized in the cytoplasm%3B~Family membership gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_774 ZOBELLIA_775 ZOBELLIA_775 ZOBELLIA_775 937799 938293 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_775 ZOBELLIA_776 ZOBELLIA_776 ZOBELLIA_776 938304 940292 + Two-component system-Sensor histidine kinase The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain%3B Contains two transmembrane segments and one N-terminal tetratrico peptide motif (TPR)%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_776 ZOBELLIA_777 ZOBELLIA_777 ZOBELLIA_777 940282 940926 + Two-component system-Response regulator Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA- binding activity (here%2C a LuxR-type HTH domain) that acts as transcriptional regulator%3B~Family membership gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_777 ZOBELLIA_778 ZOBELLIA_778 ZOBELLIA_778 940927 941436 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_778 ZOBELLIA_779 ZOBELLIA_779 ZOBELLIA_779 941459 943840 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (29-114) and the Plug module (130-226) acting as a channel gate%3B The signal peptide is cleaved between the residues 24 and 25%3B~Family membership gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_779 ZOBELLIA_78 ZOBELLIA_78 ZOBELLIA_78 82104 82397 + Conserved hypothetical protein Localized in the cytoplasm. gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_78 ZOBELLIA_780 ZOBELLIA_780 ziaA ziaA 943975 945972 - Zinc-transporting P-type ATPase ZiaA is a P-type ATPase responsible for zinc efflux using ATP hydrolysis for energy. ZiaA controls zinc homeostasis. Belongs to the cation transport P-type ATPase family. Features six transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene780 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_780 ZOBELLIA_781 ZOBELLIA_781 ZOBELLIA_781 946101 946586 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_781 ZOBELLIA_782 ZOBELLIA_782 ZOBELLIA_782 946714 947073 - Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_782 ZOBELLIA_783 ZOBELLIA_783 ZOBELLIA_783 947136 948314 - Conserved hypothetical membrane protein Protein belonging to the DUF1624 family%3B Contains eight transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_783 ZOBELLIA_784 ZOBELLIA_784 panE panE 948689 949606 + 2-Dehydropantoate 2-reductase 2-Dehydropantoate 2-reductase%2C also known as ketopantoate reductase%2C catalyzes the NADPH-dependent reduction of ketopantoate to pantoate on the pantothenate (vitamin B5) biosynthetic pathway. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_784 ZOBELLIA_785 ZOBELLIA_785 ZOBELLIA_785 949615 949956 + Hypothetical membrane protein Protein containing three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_785 ZOBELLIA_786 ZOBELLIA_786 dusA dusA 950125 951087 + tRNA-dihydrouridine synthase A tRNA-dihydrouridine synthase A catalyzes the reduction of the 5%2C6-double bond of a uridine residue%2C resulting in the formation of dihydrouridine. This modified base is found in the D-loop of most tRNAs. This enzyme uses FAD as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_786 ZOBELLIA_787 ZOBELLIA_787 ZOBELLIA_787 951246 951569 - hypothetical membrane protein Protein that contains three transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_787 ZOBELLIA_789 ZOBELLIA_789 ZOBELLIA_789 951895 952341 - Conserved hypothetical protein Conserved protein of unknown function Belongs to the GatB/YQeY family%3B Localized in the cytoplasm gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_789 ZOBELLIA_79 ZOBELLIA_79 ZOBELLIA_79 82456 83814 - MiaB-like tRNA modifying protein Contains a N-terminal UPF0004 domain of unknown function%2C a Radical SAM superfamily%2C MiaB family domain involved in 2-methylthioadenine formation and a C-terminal TRAM domain predicted to bind tRNA and deliver the RNA-modifying enzymatic domain to their targets%3B Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (SAM)%3B Localized in the cytoplasm%3B~Family membership gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_79 ZOBELLIA_790 ZOBELLIA_790 ftsZ ftsZ 952439 954400 - Cell division protein FtsZ FtsZ is the polymer-forming protein of bacterial cell division. It is part of a dynamic ring on the inner surface of the cytoplasmic membrane%2C in the middle of the dividing cell that is required for constriction of cell envelope to yield two daughter cells. The formation of the ring is the signal for septation to begin. The ring serves as a scaffold for the recruitment of the ten or so membrane and cytoplasmic proteins required for cell division and that is disassembled when septation is completed. Binds to and hydrolyzes GTP%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene790 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_790 ZOBELLIA_791 ZOBELLIA_791 ftsA ftsA 954439 955776 - Cell division protein FtsA This protein may be a component of the septum where it may interact with ftsZ. May be involved in anomalous filament growth%3B The FtsA protein contains two structurally related actin-like ATPase domains%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene791 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_791 ZOBELLIA_792 ZOBELLIA_792 ftsQ ftsQ 955780 956499 - Possible cell division protein ftsQ This hypothetical protein could be the FtsQ protein involved in septum formation. Could interact with ftsZ%2C ftsA%2C and penicillin binding protein 3. The function of FtsQ is unknown%3B Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene792 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_792 ZOBELLIA_793 ZOBELLIA_793 murC murC 956489 957862 - UDP-N-acetylmuramate-L-alanine ligase UDP-N-acetylmuramate-L-alanine ligase is an enzyme involved in the biosynthesis of peptidoglycan which catalyzes the ATP-dependent ligation of L-alanine and UDP-N-acetylmuramic acid to form UDP-N-acetylmuramyl-L-alanine%3B Contains a N-terminal transmembrane segment%3B Belongs to the MurCDEF family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene793 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_793 ZOBELLIA_794 ZOBELLIA_794 murG murG 957862 958965 - UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase%2C family GT28 MurG is involved in the peptidoglycan biosynthesis. It catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). Belongs to the family 28 of the glycosyltransferases. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene794 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_794 ZOBELLIA_795 ZOBELLIA_795 ftsW ftsW 958952 960151 - Cell division protein ftsW FtsW is a septum-peptidoglycan biosynthetic protein%2C involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division%3B Contains ten transmembrane segments%3B Belongs to the ftsW/rodA/spoVE family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene795 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_795 ZOBELLIA_796 ZOBELLIA_796 murD murD 960164 961498 - UDP-N-acetylmuramoylalanine-D-glutamate ligase UDP-N-acetylmuramoylalanine-D-glutamate ligase is an enzyme involved in the biosynthesis of peptidoglycan which catalyzes the addition of glutamic acid to the nucleotide precursor UDP-N-acetylmuramoylalanine%3B Belongs to the MurCDEF family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene796 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_796 ZOBELLIA_797 ZOBELLIA_797 mraY mraY 961500 962720 - Phospho-N-acetylmuramoyl-pentapeptide-transferase%2C family GT4 Phospho-N-acetylmuramoyl-pentapeptide-transferase is the enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate.%2C Contains ten transmembrane segmlents. Belongs to family 4 of glycosyl transferases (GT4)%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_797 ZOBELLIA_798 ZOBELLIA_798 murE murE 962760 964214 - UDP-N-acetylmuramoylalanyl-D-glutamate-2%2C6-diaminopimelate ligase UDP-N-acetylmuramoylalanyl-D-glutamate-2%2C6-diaminopimelate ligase is an enzyme involved in the biosynthesis of peptidoglycan which catalyzes the addition of diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoylalanyl-D-glutamate. This enzyme is specific of Gram-negative bacteria %3B Belongs to the MurCDEF family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_798 ZOBELLIA_799 ZOBELLIA_799 ftsI ftsI 964220 966226 - Peptidoglycan synthetase%2C family GT51 Enzyme essential for the formation of a septum of the murein sacculus. Synthetizes the cross-linked peptidoglycan from the lipid intermediates%3B Contains in its N-terminal half part a transmembrane segment and an penicillin insensitive transglycosylase domain (formation of linear glycan strands). In its C-terminal half part%2C a penicillin- sensitive transpeptidase domain (cross-linking of the peptide subunits) and a PASTA domain that binds the beta-lactam stem are present%3B Belongs to the family 51 of glycosyl transferases (GT51)%3B Except for the cytoplasmic membrane anchor region%2C The bulk of the molecule protrudes into the periplasmic space%2C where it acts on murein%3B~High confidence in function and specificity gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_799 ZOBELLIA_8 ZOBELLIA_8 degP degP 6941 8332 + Peptidase Do%2C family S1 Peptidase Do is a heat shock protein which is required for bacterial growth at elevated temperatures. It is involved in the degradation of damaged proteins. Belongs to the family 1 of the serine peptidase. Displays a catalytic triad His%2C Asp and Ser. Contains a C-terminal PDZ domain. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_8 ZOBELLIA_80 ZOBELLIA_80 ZOBELLIA_80 83926 85101 - Conserved hypothetical protein Conserved hypothetical protein. Localized in the cytoplasm. gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_80 ZOBELLIA_800 ZOBELLIA_800 ftsL ftsL 966226 966555 - Possible cell division protein FtsL Hypothetical protein that could be FtsL involved in coupling of cell division and peptidoglycan physiology%3B Contains a N-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_800 ZOBELLIA_801 ZOBELLIA_801 mraW mraW 966584 967483 - S-adenosyl-methyltransferase MraW Enzyme involved in the murein biosynthesis and that exhibits a S-adenosyl-dependent methyltransferase activity on membrane-located substrates%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_801 ZOBELLIA_802 ZOBELLIA_802 mraZ mraZ 967473 967946 - Protein MraZ Protein that could play a role in cell-wall biosynthesis and/or cell division. However%2C to date%2C there has been no clear functional assignment provided for MraZ protein. MraZ is a homooctamer or homododecamer to forms a ring%3B Localized in the cytoplasm%3B~Function unclear gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_802 ZOBELLIA_803 ZOBELLIA_803 ZOBELLIA_803 968201 968965 + Alpha/beta hydrolase-fold protein The alpha/beta hydrolase-fold proteins catalyse a wide range of enzymatic reactions. They are characterized by a catalytic triad%2C usually an serine%2C an aspartic acid%2C and an histidine%3B The core of enzyme is an alpha/beta-sheet (rather than a barrel)%2C containing 8 strands connected by helices%3B Belongs to alpha/beta hydrolase superfamily%3B Localized in the cytoplasm%3B~Function unclear gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_803 ZOBELLIA_804 ZOBELLIA_804 engB engB 968998 969615 + GTP-binding protein EngB The EngB protein is a GTPase necessary for normal cell division and for the maintenance of normal septation. Depletion of this protein leads to a severe reduction in growth rate and to extensive filamentation%2C with a block beyond the stage of segregation. Essential for bacteria survival%3B Belongs to the EngB family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_804 ZOBELLIA_805 ZOBELLIA_805 ZOBELLIA_805 969612 969992 - Conserved hypothetical protein Localized in the cytoplasm gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_805 ZOBELLIA_806 ZOBELLIA_806 ccrA ccrA 970040 970783 + Metallo-beta-lactamase CcrA hydrolyzes carbapenem and cephamycin compounds%3B Binds 2 zinc ions as cofactors%3B Belongs to the class B of the beta-lactamases family%3B Contains a putative lipoprotein signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane%3B~High confidence in function and specificity gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_806 ZOBELLIA_807 ZOBELLIA_807 ZOBELLIA_807 970813 971526 + Pirin-like protein Conserved protein highly Localized in the cytoplasm%3B~Family membership gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_807 ZOBELLIA_808 ZOBELLIA_808 gldC gldC 971535 971867 - Gliding motility protein GldC is not absolutely required for gliding motility but enhances colony spreading%3B Localized in the cytoplasm%3B~Function unclear gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_808 ZOBELLIA_809 ZOBELLIA_809 gldB gldB 971869 972828 - Gliding motility membrane lipoprotein Lipoprotein involved in the gliding motility%3B It is possible that GldB interacts with%2C or is involved in production of polysaccharides or glycoproteins%3B Signal peptide cleaved between the residues 16 and 17%3B Putatively localized in the cytoplasmic membrane%3B~Function unclear gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_809 ZOBELLIA_81 ZOBELLIA_81 rpmE rpmE 85239 85535 - Ribosomal protein L31 Protein L31 is a part of the large subunit (50S) of the ribosome%3B Belongs to the ribosomal protein L31p family%2C type B subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_81 ZOBELLIA_810 ZOBELLIA_810 nadE nadE 972809 973711 + NH(3)-dependent NAD(+) synthetase NH(3)-dependent NAD(+) synthetase catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotid%2C the transformation of deamido-NAD into NAD by a two-step reaction. This enzyme consists of a tight homodimer with alpha/beta subunit topology. Each monomer binds one ATP as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_810 ZOBELLIA_811 ZOBELLIA_811 ZOBELLIA_811 973883 974512 + Two-component system-Response regulator Response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains%2C an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor%2C and a variable C-terminal effector domain with DNA- binding activity (here a LuxR-type HTH domain) that acts as transcriptional regulator%3B~Family membership gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_811 ZOBELLIA_812 ZOBELLIA_812 ZOBELLIA_812 976563 976721 + Putative protein Hypothetical protein gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_812 ZOBELLIA_813 ZOBELLIA_813 dnaG dnaG 974600 976579 - DNA primase DNA primase is a DNA-directed RNA polymerase that synthesizes small RNA primers for the Okazaki fragments in lagging strand DNA synthesis of the replication fork during chromosomal DNA replication. It can also prime the leading strand at the Ori site. The enzyme is monomeric and interacts with the DNA helicase (DnaB)%2C single- stranded DNA binding protein (SSB) and DNA polymerase III holoenzyme forming a complex called the primosome%3B Binds one zinc ion as a cofactor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_813 ZOBELLIA_814 ZOBELLIA_814 ZOBELLIA_814 976751 977176 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_814 ZOBELLIA_815 ZOBELLIA_815 ZOBELLIA_815 977290 977853 + Conserved hypothetical protein Localized in the cytoplasm. gene gene815 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_815 ZOBELLIA_816 ZOBELLIA_816 ispB ispB 977955 978932 - Octaprenyl diphosphate synthase Octaprenyl diphosphate synthase supplies octaprenyl diphosphate%2C the precursor for the side chain of the isoprenoid quinones%2C ubiquinone and menaquinone%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene816 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_816 ZOBELLIA_817 ZOBELLIA_817 ZOBELLIA_817 979112 980152 - Radical SAM family protein Conserved protein belonging to the Radical SAM protein family. These enzymes catalyze diverse reactions%2C including unusual methylations%2C isomerization%2C sulphur insertion%2C ring formation%2C anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S center%3B Localized in the cytoplasm%3B~Family membership gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_817 ZOBELLIA_818 ZOBELLIA_818 queA queA 980236 981285 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase S-adenosylmethionine:tRNA ribosyltransferase-isomerase transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine to give epoxyqueuosine. Queuosine is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine%2C aspartate%2C histidine%2C and tyrosine tRNAs. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_818 ZOBELLIA_819 ZOBELLIA_819 aroA aroA 981457 982686 - 3-Phosphoshikimate 1-carboxyvinyltransferase 3-Phosphoshikimate 1-carboxyvinyltransferase%2C also known as 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase%2C is involved in the shikimate pathway (the sixth step). EPSP synthase catalyzes the reaction: phosphoenolpyruvate + 3-phosphoshikimate %3D phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is inhibited by the potent herbicide glyphosate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_819 ZOBELLIA_82 ZOBELLIA_82 ZOBELLIA_82 85836 86213 - Hypothetical lipoprotein Hypothetical protein containing a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the outer membrane%3B~Hypothetical protein gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_82 ZOBELLIA_820 ZOBELLIA_820 ZOBELLIA_820 982789 983115 - Nucleotide pyrophosphohydrolase family protein Conserved protein belonging to the MazG nucleotide pyrophosphohydrolase family%3B Localized in the cytoplasm%3B~Family membership gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_820 ZOBELLIA_821 ZOBELLIA_821 ZOBELLIA_821 983081 985141 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_821 ZOBELLIA_822 ZOBELLIA_822 ZOBELLIA_822 985171 987081 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_822 ZOBELLIA_823 ZOBELLIA_823 dtd dtd 987161 987613 - D-Tyrosyl-tRNA(Tyr) deacylase D-Tyrosyl-tRNA(Tyr) deacylase hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine. Can also cleave D-aspartyl-tRNA(Asp) and D-tryptophanyl-tRNA(Trp). It forms a homodimer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_823 ZOBELLIA_824 ZOBELLIA_824 engC engC 987657 988625 - GTPase engC EngC%2C has been shown to cleave GTP%2C remain bound to GDP%2C and acts as an unusual circularly permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. It is essential to cell growth. In vitro%2C EngC interacted strongly with the 30S ribosomal subunit. EngC could participates to a guanine nucleotide- dependent interaction with the ribosome and would be a novel factor in ribosome function%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_824 ZOBELLIA_825 ZOBELLIA_825 ZOBELLIA_825 988787 989230 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_825 ZOBELLIA_826 ZOBELLIA_826 aroGH aroGH 989294 990376 - 3-Deoxy-7-phosphoheptulonate synthase / Chorismate mutase Bifunctional enzyme including 3-deoxy-7-phosphoheptulonate synthase (DAHP synthase) in N-terminus and chorismate mutase in C-terminus. DAHP synthase catalyzes the first step in the common pathway leading to the biosynthesis of aromatic compounds%2C the stereospecific condensation of phosphoenolpyruvate and D-erythrose-4-phosphate giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). Chorismate mutase catalyzes the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_826 ZOBELLIA_827 ZOBELLIA_827 tyrA tyrA 990376 991236 - Prephenate dehydrogenase Prephenate dehydrogenase is involved in tyrosine biosynthesis. It catalyzes the reaction: prephenate + NAD+ %3D 4-hydroxyphenylpyruvate + CO2 + NADH. It uses NAD as a cofactor. Localized in the cytoplam.%3B~High confidence in function and specificity gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_827 ZOBELLIA_828 ZOBELLIA_828 ZOBELLIA_828 991260 992405 - Aminotransferase Aminotransferases use the Pyridoxal phosphate as cofactor bound by covalent linkage to a lysine residue%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Localized in the cytoplasm%3B~Specificity unclear gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_828 ZOBELLIA_829 ZOBELLIA_829 pheA pheA 992402 993229 - Prephenate dehydratase Prephenate dehydratase catalyzes the decarboxylation of prephenate to phenylpyruvate. PheA is involved in L-phenylalanine biosynthesis. It features a C- terminal ACT domain. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_829 ZOBELLIA_83 ZOBELLIA_83 ZOBELLIA_83 86808 87329 + Conserved hypothetical membrane protein Contains four transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene83 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_83 ZOBELLIA_830 ZOBELLIA_830 gldA gldA 993669 994565 + Gliding motility ABC transporter%2C ATPase component GldA is the nucleotide-binding domain of the permease GldF. GldA (ABC ATPase) and GldF (ABC membrane) constitute an ABC transporter involved either in the exportation of exopolysaccharides essential to gliding motility or could function to export protein components of the gliding machinery to the periplasm or cell surface%3B Localized in the cytopolasm%3B~Family membership gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_830 ZOBELLIA_831 ZOBELLIA_831 ZOBELLIA_831 994623 995090 - hypothetical protein Signal peptide cleaved between the residues 22 and 23%3B Contains two transmembrane segments%3B Probably localized in the cytoplasmic membrane gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_831 ZOBELLIA_832 ZOBELLIA_832 ZOBELLIA_832 995192 996280 - Serine peptidase%2C family S12 Serine peptidase belonging to the family S12%2C which includes D-Ala-D-Ala carboxypeptidase B and aminopeptidase DmpB. The active site residues Ser and Lys form the catalytic dyad and are found in the motif Ser-Xaa-Thr-Lys. Localized in the cytoplasm.%3B~Specificity unclear gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_832 ZOBELLIA_833 ZOBELLIA_833 ZOBELLIA_833 996367 997128 - Conserved hypothetical lipoprotein Liporoteine with a signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_833 ZOBELLIA_834 ZOBELLIA_834 ZOBELLIA_834 997203 998297 - Conserved hypothetical protein Signal peptide cleaved between the residues 18 and 19%3B Possibly localized in the outer membrane gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_834 ZOBELLIA_835 ZOBELLIA_835 metF metF 998370 999323 - 5%2C10-methylenetetrahydrofolate reductase The 5%2C10-methylenetetrahydrofolate reductase is involved in the Methionine biosynthesis reducing the 5%2C10-Methylenetetrahydrofolate to 5-methyltetrahydrofolate. The 5-methyltetrahydrofolate is utilized by methionine synthase to convert homocysteine to methionine%3B The enzyme is a FAD-containing flavoprotein homotetramer%3B Belongs to the methylenetetrahydrofolate reductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_835 ZOBELLIA_836 ZOBELLIA_836 metH metH 999516 1002254 - Methionine synthase%2C cobalamin-binding module Methionine synthase or 5-methyltetrahydrofolate-homocysteine S-methyltransferase catalyzes the transfer of a methyl group from methylcob(III)alamin to homocysteine%2C yielding enzyme-bound cob(I)alamin and methionine. Subsequently%2C remethylates the cofactor using methyltetrahydrofolate (CH3-H4folate)%3B Modular enzyme composed of a N-terminal pterin-binding module that binds the CH3-H4 folate%2C a central B12-binding module that binds the cofactor and a C-terminal AdoMet activation module that binds S-adenosyl-L-methionine essential for the reductive activation of the enzyme%3B Uses the cobalamin (vitamin B12) and zinc ion as cofactors%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_836 ZOBELLIA_837 ZOBELLIA_837 metH metH 1002299 1003300 - Methionine synthase%2C homocysteine-binding module Methionine synthase or 5-methyltetrahydrofolate-homocysteine S-methyltransferase catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine%2C yielding enzyme-bound cob(I)alamin and methionine. Subsequently%2C remethylates the cofactor using methyltetrahydrofolate%3B L-homocysteine is bound via the zinc atom%3B Uses the cobalamin (vitamin B12) and zinc as cofactors%3B This sequence corresponds to the homocysteine-binding domain (Hcy-binding domain) only%3B Belongs to the vitamin-B12 dependent methionine synthase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_837 ZOBELLIA_838 ZOBELLIA_838 ZOBELLIA_838 1003348 1003623 - Hypothetical protein Localized in the cytoplasm gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_838 ZOBELLIA_839 ZOBELLIA_839 trxB3 trxB3 1003669 1004730 - Thioredoxin reductase The active site of this enzyme is a redox-active disulfide bond. TrxB uses the FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge. In a second step%2C the reduced disulphide reduces the substrate%3B Acts as an homodimer and binds one FAD molecule per subunit%3B Belongs to the class 2 of the pyridine nucleotide- disulphide reductases (PNDR)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_839 ZOBELLIA_84 ZOBELLIA_84 arnC1 arnC1 87529 88503 + Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase%2C family GT2 ArnC catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the family 2 of the glycosyltransferase (GT2)%3B Contains three C-terminal transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene84 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_84 ZOBELLIA_840 ZOBELLIA_840 cobA1 cobA1 1004733 1005530 - Uroporphyrinogen-III C-methyltransferase This enzyme catalyzes two sequential methylation reactions%2C forming precorrin-1 and precorrin-2 by methylations at C-2 and C-7 of uroporphyrinogen III respectively%3B It is the first enzyme specific to the cobalamin (vitamin B12) pathway and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12%2C siroheme and coenzyme F430%3B Belongs to the precorrin methyltransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene840 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_840 ZOBELLIA_841 ZOBELLIA_841 sirA sirA 1005533 1007623 - Sulfite reductase [ferredoxin] Sulfite reductase catalyses the six-electron reduction reactions of sulfite to sulfide%3B Contains a Fe(4)S(4) cluster coupled to a siroheme through a cysteine bridge%3B Would contains a C-terminal HEPN domain of unknown function%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_841 ZOBELLIA_842 ZOBELLIA_842 cysN cysN 1007746 1008996 - Sulfate adenylyltransferase subunit 1 The sulfate adenylyltransferase (ATP sulfurylase) catalyses the activation of sulfate with ATP to produce 5'-phosphosulfate (APS)%2C coupled by GTP hydrolysis. The sulfate adenylyltransferase subunit 1 may be the GTPase subunit%2C regulating ATP sulfurylase activity%3B ATP sulfurylase is a heterodimer composed of cysD%2C the smaller subunit%2C and cysN%3B Belongs to the GTP-binding elongation factor family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_842 ZOBELLIA_843 ZOBELLIA_843 cysD cysD 1009054 1009956 - Sulfate adenylyltransferase subunit 2 The sulfate adenylyltransferase (ATP sulfurylase) catalyses the activation of sulfate with ATP to produce 5'-phosphosulfate (APS)%2C coupled by GTP hydrolysis. ATP sulfurylase is a heterodimer composed of cysD%2C the smaller subunit%2C and cysN%3B Belongs to the PAPS reductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_843 ZOBELLIA_844 ZOBELLIA_844 cysH cysH 1010023 1010646 - Phosphoadenosine phosphosulfate reductase The 3'-phosphoadenosine 5'-phosphosulfate (PAPS) reductase called also PAPS sulfotransferase catalyses the reduction of activated sulfate into sulfite%3B The enzyme uses thioredoxin as an electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP)%3B Belongs to the PAPS reductase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_844 ZOBELLIA_845 ZOBELLIA_845 ZOBELLIA_845 1010653 1010916 - Conserved hypothetical membrane protein Contains a C-terminal transmembrane segment%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_845 ZOBELLIA_846 ZOBELLIA_846 ZOBELLIA_846 1011096 1011506 - Rrf2-type transcriptional regulator The transcriptional regulators with the Rrf2-type HTH domain control a variety of operons that encode iron-sulfur-containing proteins as well as other proteins involved in electron transport. Other rrf2-type HTH proteins are repressors of genes involved in nitrite or iron metabolism%3B The C-terminal part of the rrf2-type HTH domain contains 3 conserved cysteine residues that may bind an Fe-S cluster%3B Contains a DNA-binding%2C winged helix-turn-helix (wHTH) domain%3B Localized in the cytoplasm%3B~Family membership gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_846 ZOBELLIA_847 ZOBELLIA_847 ZOBELLIA_847 1011715 1012371 + Conserved hypothetical membrane protein Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene847 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_847 ZOBELLIA_848 ZOBELLIA_848 ZOBELLIA_848 1012508 1013089 + Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_848 ZOBELLIA_849 ZOBELLIA_849 ZOBELLIA_849 1013175 1014065 + Metallo-beta-lactamase superfamily protein Conserved protein belonging to the zinc-dependent beta-lactamase superfamily. This superfamily contains various metallo-hydrolases including beta-lactamases%2C but also glyoxylases and arylsulfatases. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions%3B Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Family membership gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_849 ZOBELLIA_85 ZOBELLIA_85 pgcA pgcA 88543 90252 + Phosphoglucomutase Phosphoglucomutase catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. It participates in both the breakdown and synthesis of glucose. Binds one magnesium as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene85 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_85 ZOBELLIA_850 ZOBELLIA_850 ZOBELLIA_850 1014059 1014526 + Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_850 ZOBELLIA_851 ZOBELLIA_851 ZOBELLIA_851 1014824 1017571 + Polysaccharide lyase%2C family PL9 This protein is modular with a N-terminal domain belonging to the family 9 of the polysaccharide lyases (23-622) and a C-terminal conserved domain of unknown function (661-915). The PL9 domain adopts a right handed parallel beta-helix fold. In contrast to other proteins from the PL9 family%2C a conserved domain of unknown function is inserted within loops of the beta-helix core (97-271). Such domain insertion in a beta-helix has been observed in the family GH82. Features a signal peptide cleaved between residues 23 and 24. Localized in the periplasm.%3B~Specificity unclear gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_851 ZOBELLIA_852 ZOBELLIA_852 ZOBELLIA_852 1017568 1018278 + Fibronectin type-III repeats protein This conserved protein contains a C-terminal type-III fibronectin (FN3) domain. Structures of individual FN3 domains have revealed a conserved beta sandwich fold also found in bacterial glycosyde hydrolases and other proteins%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 20 and 21%3B Localized in the outer membrane%3B~Function unclear gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_852 ZOBELLIA_853 ZOBELLIA_853 metZ metZ 1018352 1019521 - O-succinylhomoserine sulfhydrylase Enzyme involved in the methionine biosynthesis%2C second step%2C transforms the O-succinylhomoserine into homocysteine%3B Uses a pyridoxal phosphate group as cofactor%2C attached to a lysine residue located in the central section of the enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_853 ZOBELLIA_854 ZOBELLIA_854 metX metX 1019550 1022942 - Homoserine O-acetyltransferase / Aspartokinase / Homoserine dehydrogenase This enzyme is a modular protein with a homoserine O-acetyltransferase module (N-terminal) that catalyses the homoserine acetylation and belongs to the alpha/beta hydrolase fold family%2C an aspartate kinase module (central) that catalyzes the phosphorylation of aspartate and belongs to the amino acid kinase family and%2C in C- terminal part%2C a homoserine dehydrogenase module that catalyzes the NAD-dependent reduction of aspartate beta- semialdehyde into homoserine. This module is composed of a substrate-binding domain (Homoserine dehydrogenase family) and a NAD-binding domain (Rossman fold)%3B MetX features also central regulatory ACT domain%3B Involved in L-Lysine%2C L-threonine and L-methionine biosynthesis pathways%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_854 ZOBELLIA_855 ZOBELLIA_855 metY metY 1023011 1024285 - Cys/Met metabolism pyridoxal-phosphate-dependent enzymes Transforms O-acetylhomoserine into L-methionine. Also reacts with other thiols and H2S%2C producing homocysteine or thioethers%3B Uses a pyridoxal phosphate group as cofactor%2C attached to a lysine residue located in the central section of the enzyme%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_855 ZOBELLIA_856 ZOBELLIA_856 metK metK 1024600 1025856 - S-adenosylmethionine synthetase S-adenosylmethionine synthetase catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps%2C AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. It forms a homotetramer and binds 2 divalent cations (Mg2+ or Co2+) and 1 potassium ion by subunit%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_856 ZOBELLIA_857 ZOBELLIA_857 ZOBELLIA_857 1026125 1028803 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (22-105) and the Plug module acting as a channel gate%3B The signal peptide is cleaved between the residues 19 and 20%3B~Specificity unclear gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_857 ZOBELLIA_858 ZOBELLIA_858 ZOBELLIA_858 1028858 1029721 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_858 ZOBELLIA_859 ZOBELLIA_859 dgkA1 dgkA1 1029830 1030531 + Deoxyguanosine kinase Deoxyguanosine kinase plays an essential role in generating the deoxyribonucleotide precursors%2C dGTP and dATP%2C for DNA metabolism. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_859 ZOBELLIA_86 ZOBELLIA_86 msbA msbA 90252 92075 + Lipid A export ATP-binding/permease protein Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane%3B Contains six N-terminal transmembrane segments (ABC membrane) that form a pore in the cytoplasmic membrane an a C-terminal ATP-binding domain (ABC ATPase) responsible for energy generation%3B Belongs to the ABC-1 type transporter permease/ATP-binding family%2C lipid exporter subfamily (msbA subfamily)%3B~High confidence in function and specificity gene gene86 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_86 ZOBELLIA_860 ZOBELLIA_860 ZOBELLIA_860 1030539 1031546 - Conserved hypothetical protein Localized in the cytoplasm gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_860 ZOBELLIA_861 ZOBELLIA_861 tonB1 tonB1 1031732 1032436 + TonB protein TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Energy flows from the cytoplasmic membrane into the outer membrane via a complex consisting of TonB%2C ExbB and ExbD proteins which are anchored in the cytoplasmic membrane. TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates%3B Belongs to the TonB family%3B Anchored in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_861 ZOBELLIA_862 ZOBELLIA_862 hpaA hpaA 1032495 1034870 - Pyrophosphate-energized proton pump Pyrophosphate-energized proton pump generates a proton motive force%3B it probably catalyzes a fully reversible reaction%2C thus being able to synthesize pyrophosphate when the proton motive force is sufficient. It controls intracellular pyrophosphate (PPi) levels and confer a favorable poise on otherwise thermodynamically unfavorable pyrophosphorylytic biosynthetic reactions. It forms a homodimer. Activated by magnesium and potassium ions. Features fifteen transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_862 ZOBELLIA_863 ZOBELLIA_863 ppa ppa 1034979 1035506 - Inorganic pyrophosphatase Inorganic pyrophosphatase is responsible for the hydrolysis of pyrophosphate (PPi) which is formed principally as the product of the many biosynthetic reactions that utilize ATP. It controls intracellular PPi levels and confer a favorable poise on otherwise thermodynamically unfavorable pyrophosphorylytic biosynthetic reactions. It forms a homohexamer and binds 4 magnesium ions per subunit. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds%2C two additional magnesium ions form complexes with substrate and product. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_863 ZOBELLIA_864 ZOBELLIA_864 ZOBELLIA_864 1035714 1038215 - Conserved hypothetical membrane protein Contains a signal peptide cleaved between the residues 18 and 19%3B Could be localized in the outer membrane%3B~Conserved hypothetical protein gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_864 ZOBELLIA_865 ZOBELLIA_865 pdhB pdhB 1038430 1039407 - Pyruvate dehydrogenase%2C E1 component subunit beta The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 component is a homodimer of an alpha and a beta subunits. PdhB is the subunit beta and displays a modular architecture. In N-terminus%2C it features a lipoyl attachment domain%2C which has a conserved lysine residue that covalently binds lipoic acid. The C-terminal domain belongs to the transketolase family and binds thiamine pyrophosphate as prosthetic group%3B Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_865 ZOBELLIA_866 ZOBELLIA_866 etfB etfB 1039582 1040322 + Electron transfer flavoprotein%2C beta subunit The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various dehydrogenases. In Bacteria%2C ETFs are produced under specific growth conditions%2C receiving electrons only from the oxidation of specific substrates. ETFs are heterodimeric proteins composed of an alpha and beta subunit%2C and contain an FAD cofactor and an AMP molecule. EtfB codes the beta subunit that binds the AMP molecule%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_866 ZOBELLIA_867 ZOBELLIA_867 etfA etfA 1040410 1041378 + Electron transfer flavoprotein%2C alpha subunit The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various dehydrogenases. In Bacteria%2C ETFs are produced under specific growth conditions%2C receiving electrons only from the oxidation of specific substrates. ETFs are heterodimeric proteins composed of an alpha and beta subunit%2C and contain an FAD cofactor and an AMP molecule. EtfA codes the alpha subunit that participate%2C with the alpha subunit%2C to the binding of the FAD molecule%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_867 ZOBELLIA_868 ZOBELLIA_868 ZOBELLIA_868 1041415 1042092 + UVR domain Protein Conserved hypothetical protein belonging to the DUF151 family. Also displays a C-terminal UVR domain (~~35 residues). The UVR domain has been first described in UvrB and UvrC%2C enzymes involved in DNA repair. This domain in UvrB can interact with the homologous domain in UvrC throughout a putative coiled coil structure%3B Localized in the cytoplasm%3B~Conserved hypothetical protein gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_868 ZOBELLIA_869 ZOBELLIA_869 nupC nupC 1042110 1043558 + Nucleoside permease NupC Except guanosine and deoxyguanosine%2C NupC transports nucleosides with a high affinity by a proton motive force%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene869 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_869 ZOBELLIA_87 ZOBELLIA_87 ZOBELLIA_87 92134 92688 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_87 ZOBELLIA_870 ZOBELLIA_870 thyA thyA 1043666 1044490 + Thymidylate synthase Thymidylate synthase catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5%2C10-methylenetetrahydrofolate to dihydrofolate. This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5%2C 10-methylenetetrahydrofolate is oxidized during one- carbon transfer. It forms a homodimer and is localized in the cytoplasm.%3B~High confidence in function and specificity gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_870 ZOBELLIA_871 ZOBELLIA_871 ZOBELLIA_871 1044561 1045733 + Conserved hypothetical protein Contains a domain found in some eukaryotic and prokaryotic protein kinase and in eukaryotic proteins required for post-translational sulphatase modification%3B Putatively localized in the outer membrane%3B Localized in the cytoplasm gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_871 ZOBELLIA_872 ZOBELLIA_872 ZOBELLIA_872 1045777 1046748 + Conserved hypothetical protein Localized in the cytoplasm gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_872 ZOBELLIA_873 ZOBELLIA_873 ZOBELLIA_873 1046816 1047097 + Conserved hypothetical protein Conserved hypothetical protein belonging to the DUF427 family. Localized in the cytoplasm.%3B~Family membership gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_873 ZOBELLIA_874 ZOBELLIA_874 ZOBELLIA_874 1047195 1047494 - Carbohydrate binding module%2C family CBM48 Carbohydrate binding module belonging to the family CBM48. CBM48s usually bind to glycogen and are associated to GH13 modules or to AMP-activated protein kinases. The exact function of this isolated CBM48 is unknown. Localized in the cytoplasm.%3B~Specificity unclear gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_874 ZOBELLIA_875 ZOBELLIA_875 cefD cefD 1047662 1048750 - Isopenicillin N epimerase Isopenicillin N epimerase catalyzes the reversible isomerization between isopenicillin N and penicillin N. Uses pyridoxal phosphate as a cofactor. Belongs to class V of the aminotransferases. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_875 ZOBELLIA_876 ZOBELLIA_876 ZOBELLIA_876 1048809 1049198 + Conserved hypothetical membrane protein Contains two transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_876 ZOBELLIA_877 ZOBELLIA_877 dfrA dfrA 1049195 1049692 + Dihydrofolate reductase Dihydrofolate reductase catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate%2C an essential step in de novo synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis). It is also important in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_877 ZOBELLIA_878 ZOBELLIA_878 murI murI 1049681 1050469 - Glutamate racemase Glutamate racemase%2C which interconverts L-glutamate into D-glutamate%2C is required for the biosynthesis of peptidoglycan and some peptide-based antibiotics such as gramicidin S. Two conserved cysteines are expected to play a role in catalytic activity by acting as bases in proton abstraction from the substrate. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_878 ZOBELLIA_879 ZOBELLIA_879 cda1 cda1 1050482 1052143 - Calcium-dependent ATPase Cda is a calcium-dependent ATPase. Vanadate strongly inhibits its activity%3B Belongs to the alkaline phosphatase clan%2C type I phosphodiesterase family%3B Signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~High confidence in function and specificity gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_879 ZOBELLIA_88 ZOBELLIA_88 ZOBELLIA_88 92700 93215 + Conserved hypothetical membrane protein Contains one transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_88 ZOBELLIA_880 ZOBELLIA_880 ZOBELLIA_880 1052293 1052994 + ABC transporter%2C permease component ABC (ATP-binding cassette) transporters are responsible for translocation of a variety of compounds across biological membranes%3B Probably%2C this protein is the membrane component of an ABC importer%3B Contains a DUF140 domain and five transmembrane segments%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_880 ZOBELLIA_881 ZOBELLIA_881 ZOBELLIA_881 1052994 1053761 + ABC transporter%2C ATPase component This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase)%3B Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane)%3B Localized in the cytoplasmic membrane as a peripheral membrane protein%3B~Family membership gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_881 ZOBELLIA_882 ZOBELLIA_882 ZOBELLIA_882 1053798 1055270 - Conserved hypothetical membrane protein Protein belonging to the DUF389 family%3B Contains six transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_882 ZOBELLIA_883 ZOBELLIA_883 manC manC 1055280 1056362 - Mannose-1-phosphate guanylyltransferase [GDP] Mannose-1-phosphate guanylyltransferase%2C also known as GDP-mannose pyrophosphorylase%2C is Involved in the biosynthesis of exopolysaccharides. It catalyzes the reaction: GDP + alpha-D-mannose 1-phosphate %3D phosphate + GDP-mannose. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene883 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_883 ZOBELLIA_884 ZOBELLIA_884 ZOBELLIA_884 1056459 1057070 - SprT family protein Conserved protein belonging to a family including SprT%2C a regulator of bolA gene in stationary phase. Displays a conserved HExxH motif reminiscent of the metallopeptidase zinc binding signature. Localized in the cytoplasm.%3B~Family membership gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_884 ZOBELLIA_885 ZOBELLIA_885 ZOBELLIA_885 1057168 1057848 - Short-chain dehydrogenase/reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%2C Glucose/ribitol dehydrogenase subfamily%3B Most dehydrogenases possess at least 2 domains%2C the first binding the coenzyme%2C often NAD%2C and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis%3B Localized in the cytoplasm%3B~Family membership gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_885 ZOBELLIA_886 ZOBELLIA_886 ZOBELLIA_886 1057848 1058900 - Metallopeptidase%2C family M28 Family M28 contains aminopeptidases and carboxypeptidases with two co-catalytic zinc ions. Each zinc ion is tetrahedrally co-ordinated%2C with three amino acid ligands plus activated water%3B one aspartate residue binds both metal ions. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer and/or cytoplasmic membrane%3B~Specificity unclear gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_886 ZOBELLIA_887 ZOBELLIA_887 pdhC pdhC 1058989 1060617 - Dihydrolipoyllysine-residue acetyltransferase%2C PDH complex E2 component The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2%2C linking glycolysis to the tricarboxylic acid cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). PdhC is the E2 component and is a dihydrolipoyllysine-residue acetyltransferase. It catalyzes the reaction: Acetyl-CoA + enzyme 6-N-(dihydrolipoyl)lysine %3D CoA + enzyme 6-N-(S-acetyldihydrolipoyl)lysine. PdhC features two N-terminal lipoyl-binding domains%2C a central E3- binding domain%2C and a C-terminal catalytic domain belonging to the 2-oxoacid dehydrogenases acyltransferase family. Each lipoyl-binding domain has a conserved lysine residue that covalently binds lipoic acid. PdhC forms a 24- polypeptide structural core with octahedral symmetry. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_887 ZOBELLIA_888 ZOBELLIA_888 pdhA pdhA 1060626 1061621 - Pyruvate dehydrogenase%2C E1 component subunit alpha The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2%2C linking glycolysis to the tricarboxylic acid cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 component is a homodimer of an alpha and a beta subunits. PdhB is the subunit beta and displays a modular architecture. In N-terminus%2C it features a lipoyl attachment domain%2C which has a conserved lysine residue that covalently binds lipoic acid. The C-terminal domain belongs to the transketolase family and binds thiamine pyrophosphate as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_888 ZOBELLIA_889 ZOBELLIA_889 cdd cdd 1061774 1062256 - Cytidine deaminase Cytidine deaminase scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. It catalyzes the reaction: cytidine + H2O %3D uridine + NH3. It forms a homotetramer and binds 1 zinc ion per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_889 ZOBELLIA_89 ZOBELLIA_89 ZOBELLIA_89 93208 93669 + Conserved hypothetical protein Contains a signal peptide cleaved between the residues 21 and 22%3B Localized in the periplasmic space gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_89 ZOBELLIA_890 ZOBELLIA_890 ZOBELLIA_890 1062332 1063483 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_890 ZOBELLIA_891 ZOBELLIA_891 gldJ gldJ 1063946 1065613 + Gliding motility membrane lipoprotein Lipoprotein involved in the gliding motility that contains an unknown function domain found in some eukaryotic and prokaryotic protein and in eukaryotic proteins required for post-translational modification of sulfatase%3B Signal peptide cleaved between the residues 23 and 24%3B Putatively localized in the outer membrane%3B~Function unclear gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_891 ZOBELLIA_892 ZOBELLIA_892 murF1 murF1 1065652 1066959 + UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF) is an enzyme involved in the final step of the biosynthesis of peptidoglycan. MurF catalyzes the addition of D-alanyl-D-alanine to the nucleotide precursor UDP-N- acetylmuramoyl-L-alanyl-D-glutamyl-meso-2%2C6-diaminoheptanedioate%3B Belongs to the MurCDEF family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_892 ZOBELLIA_893 ZOBELLIA_893 ZOBELLIA_893 1067024 1067848 - MscS family protein Conserved membrane protein belonging to the Small-conductance mechanosensitive channel family%3B Contains five transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_893 ZOBELLIA_894 ZOBELLIA_894 ZOBELLIA_894 1067867 1068052 - Putative protein Hypothetical protein gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_894 ZOBELLIA_895 ZOBELLIA_895 ZOBELLIA_895 1068568 1068951 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_895 ZOBELLIA_896 ZOBELLIA_896 ZOBELLIA_896 1068057 1068602 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to promoters and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra- cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_896 ZOBELLIA_897 ZOBELLIA_897 ZOBELLIA_897 1069299 1069505 + Putative protein Hypothetical protein gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_897 ZOBELLIA_899 ZOBELLIA_899 ZOBELLIA_899 1070186 1071556 + Conserved hypothetical membrane protein Contains four transmembrane helices in the N-terminal region and a central motif reminiscent of the Planctomycete cytochrome C motif%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_899 ZOBELLIA_9 ZOBELLIA_9 gapD gapD 8449 9897 + Glyceraldehyde 3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1%2C3-diphospho-glycerate. Also it plays an important role in gluconeogenesis%3B Acts as an homotetramer%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_9 ZOBELLIA_90 ZOBELLIA_90 ZOBELLIA_90 93682 94710 - BNR repeats protein Protein containing four BNR (bacterial neuraminidase repeat) repeats. These repeats are found in many glycoside hydrolases as well as other extracellular proteins of unknown function. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 15 and 16%3B Localized in the outer membrane%3B~Family membership gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_90 ZOBELLIA_900 ZOBELLIA_900 ZOBELLIA_900 1071803 1072066 - Endonuclease Protein that consists of an GIY-YIG catalytic domain of unknown function found in the amino terminal region of excinuclease abc subunit c (region 1 of UvrC) and in few other nucleases from bacteria and bacteriophages%3B Localized in the cytoplasm%3B~Function unclear gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_900 ZOBELLIA_902 ZOBELLIA_902 folC folC 1072244 1073428 - Folylpolyglutamate synthase / Dihydrofolate synthase Bifunctional enzyme that converts the folates to polyglutamate derivatives%3B Folylpolyglutamate synthase (EC 6.3.2.17) is responsible for the ATP-dependent addition of a polyglutamate tail to tetrahydrofolate. Dihydrofolate synthase (EC 6.3.2.12) is reponsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate. The combined activity leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlu(n))%2C i.e. various tetrahydrofolates (H4folate)%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_902 ZOBELLIA_903 ZOBELLIA_903 tolA tolA 1073452 1074393 - Protein TolA TolA%2C involved in the tonB-independent uptake of proteins%2C interacts with the TolQ and TolR%2C cytoplasmic membrane proteins and with the Pal protein (OprL) in the outer membrane. The transport is energized by the proton motive force. The Tol-Pal complex is required for maintaining outer membrane integrity%2C the transport (uptake) filamentous DNA and is the conduct for bacteriophages%3B TolA is anchored to the cytoplasmic membrane by a single transmembrane spanning segment near the N-terminus%2C leaving most of the protein exposed to the periplasm%3B~High confidence in function and specificity gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_903 ZOBELLIA_904 ZOBELLIA_904 tolR tolR 1074393 1074779 - Protein TolR TolR%2C involved in the tonB-independent uptake of biopolymers%2C forms a complex with the proteins TolQ. This complex energizes TolA from the potential energy of the ion electrochemical gradient. TolA energized%2C interacts with the outer membrane protein Pal (OprL). The Tol-Pal complex is required for maintaining outer membrane integrity%2C the transport (uptake) filamentous DNA and is the conduct for bacteriophages%3B Contains a N-terminal transmembrane helix%3B Belongs to the exbD/tolR family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_904 ZOBELLIA_905 ZOBELLIA_905 tolQ tolQ 1074790 1075482 - Protein TolQ TolQ%2C involved in the tonB-independent uptake of biopolymers%2C forms a complex with the proteins TolR. This complex energizes TolA from the potential energy of the ion electrochemical gradient. TolA energized%2C interacts with the outer membrane protein Pal (OprL). The Tol-Pal complex is required for maintaining outer membrane integrity%2C the transport (uptake) filamentous DNA and is the conduct for bacteriophages%3B Contains three transmembrane helices%3B Belongs to the exbB/tolQ family%3B Localized in the cytoplasmic membrane%3B~High confidence in function and specificity gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_905 ZOBELLIA_906 ZOBELLIA_906 ZOBELLIA_906 1075534 1076901 - Citrate transporter family protein Conserved protein belonging to the citrate transporter family%2C which includes two characterized citrate/proton symporters from Bacillus subtilis. Its exact specificity is unknown. Features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~Family membership gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_906 ZOBELLIA_907 ZOBELLIA_907 ZOBELLIA_907 1076915 1078147 - NAD(P)-dependent oxidoreductase NAD(P)-dependent dehydrogenase distantly related to glutamate dehydrogenase%3B Localized in the cytoplasm%3B~Specificity unclear gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_907 ZOBELLIA_908 ZOBELLIA_908 bcdA bcdA 1078432 1079574 + Butyryl-CoA dehydrogenase Butyryl-CoA dehydrogenase converts the Butanoyl-CoA to 2-butenoyl-CoA. It uses electron transfer flavoprotein (FAD) as its electron acceptor%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_908 ZOBELLIA_909 ZOBELLIA_909 gltA gltA 1079891 1084399 + Glutamate synthase [NADPH] large chain Glutamate synthase is a key enzyme in the early stages of the assimilation of ammonia. It is a complex iron-sulfur flavoprotein catalyzing the reductive transfer of the amido nitrogen from L-glutamine to 2-oxoglutarate to form two molecules of L-glutamate via intramolecular channelling of ammonia from the amidotransferase domain to the FMN-binding domain. Glutamate synthase forms an aggregate of 4 catalytic active heterodimers%2C consisting of a large and a small subunit (GltB). GltA binds as cofactors a 3Fe-4S cluster%2C a FAD and a FMN. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_909 ZOBELLIA_91 ZOBELLIA_91 rsmB rsmB 94783 95994 + Ribosomal RNA small subunit methyltransferase B RsmB specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. It uses S-adenosyl-L-methionine as cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_91 ZOBELLIA_910 ZOBELLIA_910 gltB gltB 1084409 1085875 + Glutamate synthase [NADPH] small chain Glutamate synthase is a key enzyme in the early stages of the assimilation of ammonia. It is a complex iron-sulfur flavoprotein catalyzing the reductive transfer of the amido nitrogen from L-glutamine to 2-oxoglutarate to form two molecules of L-glutamate via intramolecular channelling of ammonia from the amidotransferase domain to the FMN-binding domain. Glutamate synthase forms an aggregate of 4 catalytic active heterodimers%2C consisting of a large (GltA) and a small subunit . GltB binds NADP(H) as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_910 ZOBELLIA_911 ZOBELLIA_911 ZOBELLIA_911 1085928 1086842 + Conserved hypothetical membrane protein Protein containing two tandem domains belonging to the DUF6 family. Predicted as a transporter%3B Contains ten transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_911 ZOBELLIA_912 ZOBELLIA_912 ZOBELLIA_912 1086930 1088477 - Sulfatase%2C family S1-28 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 28%3B Signal peptide cleaved between the residues 19 and 20%3B Localized in the outer membrane%3B~Family membership gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_912 ZOBELLIA_913 ZOBELLIA_913 ZOBELLIA_913 1088539 1089975 - Sulfatase%2C family S1-23 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 23%3B Signal peptide of Lipoprotein cleaved between the residues 16 and 17%3B Localized in the outer membrane%3B~Family membership gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_913 ZOBELLIA_914 ZOBELLIA_914 ZOBELLIA_914 1090188 1091639 - SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 20 and 21%3B Probably localized in the outer membrane%3B~Family membership gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_914 ZOBELLIA_915 ZOBELLIA_915 ZOBELLIA_915 1091657 1095112 - TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain (67-119)) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (142-216)%2C and a Plug module (232-356) acting as the channel gate%3B The signal peptide is cleaved between the residue 21 and 22%3B~Family membership gene gene915 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_915 ZOBELLIA_916 ZOBELLIA_916 ZOBELLIA_916 1095245 1096381 - Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Family membership gene gene916 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_916 ZOBELLIA_917 ZOBELLIA_917 ZOBELLIA_917 1096658 1097197 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene917 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_917 ZOBELLIA_918 ZOBELLIA_918 ZOBELLIA_918 1097243 1098364 - Conserved hypothetical membrane protein Conserved protein containing a putative lipoprotein signal peptide cleaved between the residues 15 and 16%3B Possibly localized in the outer membrane%3B~Conserved hypothetical protein gene gene918 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_918 ZOBELLIA_919 ZOBELLIA_919 ZOBELLIA_919 1098391 1099236 - D-tagatose 3-epimerase D-Tagatose 3-epimerase catalyzes the epimerization of various ketohexoses at the C3 position. It folds into a Xylose isomerase-like TIM barrel. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene919 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_919 ZOBELLIA_92 ZOBELLIA_92 purL purL 96094 99777 + Phosphoribosylformylglycinamidine synthase PurL is involved in purine biosynthesis. It catalyzes the conversion of formylglycinamide ribonucleotide (FGAR)%2C glutamine%2C and MgATP to formylglycinamidine ribonucleotide%2C glutamate%2C ADP%2C and Pi. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_92 ZOBELLIA_920 ZOBELLIA_920 ZOBELLIA_920 1099445 1100326 - AraC-type transcriptional regulator The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic%2C metabolic and transport operons%3B Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization%3B Localized in the cytoplasm%3B~Family membership gene gene920 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_920 ZOBELLIA_921 ZOBELLIA_921 ZOBELLIA_921 1100664 1103834 + Conserved cytochrome c-containing protein Large conserved protein containing a C-terminal cytochrome c. Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 14 and 15%3B Localized in the outer membrane%3B~Family membership gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_921 ZOBELLIA_922 ZOBELLIA_922 ZOBELLIA_922 1104394 1107564 + TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations%3B Contains a carboxypeptidase regulatory domain (57-131) and the Plug module (147-263) acting as a channel gate%3B The signal peptide is cleaved between the residues 29 and 30%3B~Family membership gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_922 ZOBELLIA_923 ZOBELLIA_923 ZOBELLIA_923 1107586 1109094 + SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Contains a lipoprotein signal peptide cleaved between the residues 22 and 23%3B Probably localized in the outer membrane%3B~Family membership gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_923 ZOBELLIA_929 ZOBELLIA_929 ZOBELLIA_929 1115299 1115508 + Putative protein Hypothetical protein gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_929 ZOBELLIA_93 ZOBELLIA_93 ZOBELLIA_93 99900 102473 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_93 ZOBELLIA_930 ZOBELLIA_930 ZOBELLIA_930 1115572 1117572 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_930 ZOBELLIA_931 ZOBELLIA_931 rnhB rnhB 1117822 1118427 + Ribonuclease HII Ribonuclease HII is involved in the degradation of the ribonucleotide moiety on RNA-DNA hybrid molecules carrying out endonucleolytic cleavage to 5'-phospo-monoester. Binds 1 divalent metal ion (manganese or magnesium) in the absence of substrate. May bind a second metal ion after substrate binding. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_931 ZOBELLIA_932 ZOBELLIA_932 ZOBELLIA_932 1118656 1119999 + OmpA-like periplasmic protein This conserved protein contains a N-terminal glucanase-like beta-sandwich domain of unknown function and a C-terminal OmpA-like domain. OmpA-like domains are thought to be responsible for non-covalent interactions with peptidoglycan%3B Signal peptide cleaved between the residues 26 and 27%3B Localized in the outer membrane and/or periplasm%3B~Family membership gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_932 ZOBELLIA_933 ZOBELLIA_933 ZOBELLIA_933 1120012 1120710 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 20 and 21%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_933 ZOBELLIA_934 ZOBELLIA_934 ZOBELLIA_934 1120745 1122109 + Serine peptidase%2C family S8 Serine peptidase contains a catalytic triad in the order Asp%2C His and Ser in the sequence. Its structure consists of three layers with a seven-stranded beta sheet sandwiched between two layers of helices%3B Belongs to the family S8 of peptidases%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18%3B Localized in the cytoplasmic membrane%3B~Specificity unclear gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_934 ZOBELLIA_935 ZOBELLIA_935 ZOBELLIA_935 1122149 1125052 + TPR repeats protein Conserved protein containing three N-terminal tetratrico peptide repeats (TPRs) and a C-terminal conserved domain of unknown function. TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes%3B Contains a C-terminal transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_935 ZOBELLIA_936 ZOBELLIA_936 ZOBELLIA_936 1125055 1125792 - Conserved hypothetical membrane protein Contains one central transmembrane helix%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_936 ZOBELLIA_937 ZOBELLIA_937 ZOBELLIA_937 1125795 1126364 - RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released. They alter the specificity of promoter recognition. This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors.%3B~Family membership gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_937 ZOBELLIA_938 ZOBELLIA_938 ZOBELLIA_938 1126484 1126702 - Putative protein Hypothetical protein gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_938 ZOBELLIA_939 ZOBELLIA_939 ZOBELLIA_939 1126843 1127151 + Conserved hypothetical protein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%2C Probably localized in the outer membrane gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_939 ZOBELLIA_94 ZOBELLIA_94 fadD fadD 102745 104520 + Long-chain-fatty-acid-CoA ligase FadD catalyzes the esterification%2C concomitant with transport%2C of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It forms a homodimer. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene94 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_94 ZOBELLIA_940 ZOBELLIA_940 ZOBELLIA_940 1127601 1128341 + Conserved hypothetical protein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG). Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 23 and 24%3B Localized in the outer membrane gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_940 ZOBELLIA_941 ZOBELLIA_941 ZOBELLIA_941 1128418 1128549 + Putative protein Hypothetical protein gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_941 ZOBELLIA_942 ZOBELLIA_942 ZOBELLIA_942 1128760 1129056 - Putative membrane protein Contains a transmembrane helix%3B Putatively localized in the cytoplasmic membrane%3B~Hypothetical protein gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_942 ZOBELLIA_943 ZOBELLIA_943 ZOBELLIA_943 1129062 1130117 + Hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 24 and 25%3B Localized in the periplasmic space%3B~Hypothetical protein gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_943 ZOBELLIA_944 ZOBELLIA_944 ZOBELLIA_944 1130200 1131222 + Kelch repeats protein This conserved protein displays Kelch repeats. The kelch motif forms a beta sheet and several of these sheets associate to form a beta propeller structure%2C as demonstrated for galactose oxidase. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane%3B~Function unclear gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_944 ZOBELLIA_945 ZOBELLIA_945 ZOBELLIA_945 1131591 1132145 + Hypothetical protein Hypothetical protein. Putatively localized in the cytoplasm. gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_945 ZOBELLIA_946 ZOBELLIA_946 ZOBELLIA_946 1132248 1132859 + Conserved hypothetical protein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_946 ZOBELLIA_947 ZOBELLIA_947 ZOBELLIA_947 1132975 1133622 + Conserved hypothetical protein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane gene gene947 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_947 ZOBELLIA_948 ZOBELLIA_948 ZOBELLIA_948 1133736 1133912 + Putative protein Hypothetical protein gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_948 ZOBELLIA_949 ZOBELLIA_949 ZOBELLIA_949 1134030 1134650 + Conserved hypothetical protein Conserved hypothetical protein including an N-terminal region rich in glycine%2C reminiscent of the collagen triple helix repeats (GxxG)%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22%3B Localized in the outer membrane gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_949 ZOBELLIA_95 ZOBELLIA_95 ZOBELLIA_95 104706 105188 + MarR-type transcriptional regulator The transcriptional regulators with the marR-type HTH domain control a variety of biological functions%2C including resistance to multiple antibiotics%2C household disinfectants%2C organic solvents%2C oxidative stress agents. Many of the marR-like regulators respond to aromatic compounds%3B Contains a DNA-binding%2C winged helix-turn-helix (wHTH) domain%3B Localized in the cytoplasm%3B~Family membership gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_95 ZOBELLIA_950 ZOBELLIA_950 lipB lipB 1134687 1135406 - Lipoyltransferase Lipoyltransferase catalyzes the transfer of the endogenously synthesized lipoate to apoproteins%2C creating an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoate-dependent enzymes. Utilizes lipoyl-acyl-carrier-protein as a source of lipoyl groups%2C although octanoyl groups from octanoyl-ACP can also be transferred to the lipoyl domain of apoproteins. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_950 ZOBELLIA_951 ZOBELLIA_951 ZOBELLIA_951 1135433 1136170 - Conserved hypothetical lipoprotein Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane%3B~Conserved hypothetical protein gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_951 ZOBELLIA_952 ZOBELLIA_952 ZOBELLIA_952 1136202 1136360 + Conserved hypothetical protein Protein fragment found in hypothetical proteins from Flavobacteriaceae%3B Putatively localized in the cytoplasm gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_952 ZOBELLIA_953 ZOBELLIA_953 lysS lysS 1136557 1138245 + Lysyl-tRNA synthetase Lysyl-tRNA synthetase catalyzes the attachment of L-lysine to the tRNA(Lys) in a highly specific two-step reaction. LysS is an homodimer and binds 3 magnesium ions per subunit%3B Belongs to the class II of the aminoacyl-tRNA synthetases%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_953 ZOBELLIA_954 ZOBELLIA_954 ZOBELLIA_954 1138652 1141390 + Conserved cytochrome c-containing protein This protein has a modular architecture with a N-terminal cytochrome c%2C a central domain of unknown function (DUF1549) which includes a second cytochrome c and a C-terminal domain of unknown function (DUF1553). Cytochromes c typically function in electron transfer%2C but c-type cytochrome centers are also found in the active sites of many enzymes. The two domains DUF1549 and DUF1553 are usually found in Planctomycetes. Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 24 and 25%3B Localized in the outer membrane%3B~Function unclear gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_954 ZOBELLIA_955 ZOBELLIA_955 ZOBELLIA_955 1141394 1142905 + Conserved hypothetical protein Conserved hypothetical protein (family DUF1501). Belongs to the alkaline-phosphatase clan. Features a twin-arginine signal peptide. Localized in the periplasm.%3B~Family membership gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_955 ZOBELLIA_956 ZOBELLIA_956 ZOBELLIA_956 1142936 1143808 + TIM-barrel fold protein Conserved protein adopting a xylose-isomerase-like TIM barrel fold%3B Contains an uncleavable signal peptide%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_956 ZOBELLIA_957 ZOBELLIA_957 ZOBELLIA_957 1143818 1145209 + Conserved hypothetical membrane protein Contains five transmembrane helices in the N-terminal region and a central motif reminiscent of the Planctomycetes cytochrome C motif%3B Localized in the cytoplasmic membrane.%3B~Conserved hypothetical protein gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_957 ZOBELLIA_958 ZOBELLIA_958 sdcS sdcS 1145260 1146690 + Sodium-dependent dicarboxylate transporter sdcS Sodium-dependent dicarboxylate transporter sdcS mediates the transport of dicarboxylates across the cytoplasmic membrane via a Na(+)-electrochemical gradient. Features thirteen transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_958 ZOBELLIA_959 ZOBELLIA_959 ZOBELLIA_959 1146775 1147182 - Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 22 and 23%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene959 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_959 ZOBELLIA_96 ZOBELLIA_96 fadN fadN 105211 107616 + 3-Hydroxyl-CoA dehydrogenase / Enoyl-CoA hydratase Modular protein containing a N-terminal 3-Hydroxyl-CoA dehydrogenase domain and a C-terminal Enoyl-CoA hydratase domain. In Bacillus subtilis%2C this protein was formerly known as YusL%2C and has been renamed FadN by Matsuoka et al (JBC%2C 2007). FadN is involved in fatty acid degradation. 3-Hydroxyl-CoA dehydrogenase catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. It uses NAD as cofactor. Enoyl-CoA hydratase catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_96 ZOBELLIA_960 ZOBELLIA_960 ZOBELLIA_960 1147674 1150169 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 23 and 24%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene960 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_960 ZOBELLIA_961 ZOBELLIA_961 ZOBELLIA_961 1150882 1151325 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 18 and 19%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene961 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_961 ZOBELLIA_962 ZOBELLIA_962 ZOBELLIA_962 1151463 1151957 + Conserved hypothetical protein Localized in the cytoplasm gene gene962 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_962 ZOBELLIA_963 ZOBELLIA_963 hemL hemL 1152102 1153382 - Glutamate-1-semialdehyde 2%2C1-aminomutase. Glutamate-1-semialdehyde 2%2C1-aminomutase or Glutamate-1-semialdehyde aminotransferase (GSA) is a isomerase that catalyses the intramolecular transfer of amino group from C4 to C5 yielding the conversion of L-glutamate-1-semialdehyde (or (S)-4-amino-5-oxopentanoate) to 5-aminolevulinate during the second step of porphyrin biosynthesis by the C5 pathway%3B Uses the Pyridoxal phosphate as cofactor linked to a conserved lysine residue%3B Belongs to the class-III pyridoxal-phosphate - dependent aminotransferase family%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene963 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_963 ZOBELLIA_964 ZOBELLIA_964 ZOBELLIA_964 1153383 1154240 - Endo-beta-N-acetylglucosaminidase%2C family GH73 This enzyme%2C probably involved in peptidoglycan metabolism%2C is a modular protein with a N-terminal endo-beta-N-acetylglucosaminidase domain and a C-terminal LysM peptidoglycan-binding domain. Endo-beta-N-acetylglucosaminidase catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. The catalytic module belongs to the family 73 of the glycoside hydrolases (GH73). LysM domains belongs to the family 50 of the carbohydrate binding modules (CBM50). Contains a putative lipoprotein signal peptide cleaved between the residues 17 and 18%3B Possibly localized in the outer membrane%3B~Specificity unclear gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_964 ZOBELLIA_965 ZOBELLIA_965 dcyD dcyD 1154237 1155148 - D-cysteine desulfhydrase D-cysteine desulfhydrase catalyzes the alpha%2Cbeta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine. It uses pyridoxal phosphate as a cofactor. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_965 ZOBELLIA_966 ZOBELLIA_966 ZOBELLIA_966 1155215 1155544 - Conserved hypothetical protein Localized in the cytoplasm gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_966 ZOBELLIA_967 ZOBELLIA_967 ZOBELLIA_967 1155747 1155908 + Conserved hypothetical protein Localized in the cytoplasm. gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_967 ZOBELLIA_968 ZOBELLIA_968 ZOBELLIA_968 1155987 1156544 + Conserved hypothetical periplasmic protein Contains a signal peptide cleaved between the residues 27 and 28%3B Localized in the periplasmic space%3B~Conserved hypothetical protein gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_968 ZOBELLIA_969 ZOBELLIA_969 phhA phhA 1156665 1158428 + phenylalanine 4-monooxygenase Phenylalanine 4-monooxygenase%2C also known as phenylalanine-4-hydroxylase%2C is involved in L-phenylalanine biodegradation. It catalyzes the reaction: L-phenylalanine + tetrahydrobiopterin + O2 %3D L-tyrosine + 4a-hydroxytetrahydrobiopterin. It binds Fe(2+) ion as a cofactor. PhhA belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_969 ZOBELLIA_97 ZOBELLIA_97 ZOBELLIA_97 107661 108008 + 23S ribosomal protein Bacterial 23S rRNA proteins are a proteins encoded within an intervening sequence present within some 23S rRNA genes%3B The function of these proteins is not known%3B 23S ribosomal protein forms a homopentamer%3B Localized in the cytoplasm%3B~Family membership gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_97 ZOBELLIA_970 ZOBELLIA_970 ZOBELLIA_970 1158517 1159725 + Conserved hypothetical protein Localized in the cytoplasm. gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_970 ZOBELLIA_971 ZOBELLIA_971 ZOBELLIA_971 1159737 1160351 - Conserved hypothetical membrane protein Contains an uncleaved signal sequence%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_971 ZOBELLIA_972 ZOBELLIA_972 ZOBELLIA_972 1160401 1161363 - Conserved hypothetical protein Localized in the cytoplasm gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_972 ZOBELLIA_973 ZOBELLIA_973 ZOBELLIA_973 1161432 1161737 - Conserved hypothetical membrane protein Contains three transmembrane helices%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_973 ZOBELLIA_974 ZOBELLIA_974 ZOBELLIA_974 1161721 1161849 - Putative protein Hypothetical protein gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_974 ZOBELLIA_975 ZOBELLIA_975 ZOBELLIA_975 1161949 1162503 - Crp/Fnr-type transcriptional regulator The Crp/Fnr-type transcriptional regulators complexe with cyclic AMP and bind to operator sites near the promoter with a C-terminal HTH domain to regulate the transcription of several catabolite-sensitive operons%3B They predominantly act as transcription activators%2C but can also be important repressors%2C and respond to diverse intracellular and exogenous signals%3B Localized in the cytoplasm%3B~Family membership gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_975 ZOBELLIA_976 ZOBELLIA_976 ZOBELLIA_976 1162602 1163276 - Conserved hypothetical protein Localized in the cytoplasm gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_976 ZOBELLIA_977 ZOBELLIA_977 alaS alaS 1163516 1166131 - Alanyl-tRNA synthetase Alanyl-tRNA synthetase catalyses the attachment of alanine to its cognate transfer RNA molecule in a highly specific two-step reaction. AlaS forms is a homotetramer and belongs to the class II of the aminoacyl-tRNA synthetases. Binds 1 zinc ion per subunit. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_977 ZOBELLIA_978 ZOBELLIA_978 ZOBELLIA_978 1166233 1167210 + Metallopeptidase%2C family M23 Peptidase family M23 mainly contains endopeptidases that lyze bacterial cell wall peptidoglycans. One catalytic zinc ion is bound per peptidase molecule. The cation ligands occur in the conserved motifs HXXXD and HXH. The first histidine of the second motif is also involved in the catalysis. Features a transmembrane helix in N-terminus. Localized in the cytoplasmic membrane.%3B~Specificity unclear gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_978 ZOBELLIA_979 ZOBELLIA_979 ZOBELLIA_979 1167210 1167539 + MerR-type transcriptional regulator Transcriptional regulator belonging to the MerR family. Contains a N-terminal helix-turn-helix DNA binding motif%3B Forms a dimer%3B Localized in the cytoplasm%3B~Specificity unclear gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_979 ZOBELLIA_98 ZOBELLIA_98 fadA fadA 108048 109238 + 3-Ketoacyl-CoA thiolase 3-Ketoacyl-CoA thiolase%2C also known as acetyl-CoA C-acyltransferase%2C has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. It catalyzes the reaction: Acyl-CoA + acetyl-CoA %3D CoA + 3-oxoacyl-CoA. Localized in the cytoplasm.%3B~High confidence in function and specificity gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_98 ZOBELLIA_980 ZOBELLIA_980 ZOBELLIA_980 1167624 1168223 + LemA family protein Conserved protein belonging to the LemA family. LemA contains an amino terminal domain predicted as transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain%3B Localized in the cytoplasmic membrane%3B~Family membership gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_980 ZOBELLIA_981 ZOBELLIA_981 ZOBELLIA_981 1168230 1168670 + Conserved hypothetical protein Conserved protein belonging to the DUF477 family%3B Localized in the cytoplasm%3B~Family membership gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_981 ZOBELLIA_982 ZOBELLIA_982 ZOBELLIA_982 1168651 1169442 + Conserved hypothetical membrane protein Conserved protein belonging to the DUF477 family%3B Contains one C-terminal transmembrane segment%3B Contains a signal peptide cleaved between the residues 19 and 20%3B Localized in the cytoplasmic membrane%3B~Conserved hypothetical protein gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_982 ZOBELLIA_983 ZOBELLIA_983 ZOBELLIA_983 1169561 1170406 + Hypothetical protein Putatively localized in the cytoplasm gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_983 ZOBELLIA_984 ZOBELLIA_984 ZOBELLIA_984 1170403 1173192 - TonB-dependent Receptor Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations. Contains a carboxypeptidase regulatory domain (28-112) and the Plug module (127-183) acting as a channel gate%3B The signal peptide is cleaved between the residues 25 and 26%3B~Family membership gene gene984 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_984 ZOBELLIA_985 ZOBELLIA_985 engA engA 1173333 1174637 - GTP-binding protein EngA EngA is a GTPase of unknown physiological role but seems essential for cell viability%3B Contains two GTPase domain%3B Belongs to the Era/TrmE GTP-binding protein family%2C EngA subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene985 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_985 ZOBELLIA_986 ZOBELLIA_986 ZOBELLIA_986 1174783 1176318 - Conserved hypothetical protein Conserved protein likely adopting a beta-propeller fold%3B Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19%3B Localized in the outer membrane gene gene986 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_986 ZOBELLIA_987 ZOBELLIA_987 eraA eraA 1176426 1177310 - GTP-binding protein Era Era (E. coli Ras-like protein) is a multifunctional GTPase It binds to the 16S rRNA of the 30S subunit and appears to play a role in the assembly of the 30S subunit%2C possibly by chaperoning the 16S rRNA. Binds both GDP and GTP%2C has an intrinsic GTPase activity and is essential for cell growth%3B Contains a N-terminal GTPase domain and a C-terminal KH type-2 domain that is critical for RNA binding%3B Belongs to the Era/TrmE GTP-binding protein family%2C Era subfamily%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene987 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_987 ZOBELLIA_988 ZOBELLIA_988 ZOBELLIA_988 1177297 1178718 - Sodium / alanine symporter This permease transports alanine in association with sodium ions. It forms a channel through the cytoplasmic membrane%2C the interior face being hydrophilic to allow the passage of alanine molecules and sodium ions. Features eleven transmembrane helices. Localized in the cytoplasmic membrane.%3B~High confidence in function and specificity gene gene988 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_988 ZOBELLIA_99 ZOBELLIA_99 fadE fadE 109269 111065 + Acyl-CoA dehydrogenase Acyl-CoA dehydrogenase is involved in fatty acid degradation. It catalyzes the alpha%2Cbeta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2%2C3- enoyl CoA-products with concommitant reduction of enzyme- bound FAD. In Bacillus subtilis%2C this protein%2C formerly known as yusJ protein%2C has been renamed FadE by Matsuoka et al (JBC%2C 2007). Localized in the cytoplasm.%3B~Specificity unclear gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_99 ZOBELLIA_990 ZOBELLIA_990 ZOBELLIA_990 1179039 1180025 - Transposase%2C family 12 The transposases are encoded by mobile genetic elements such as transposon or insertion sequences (IS). Transposases catalyze the transposition%2C by site-specific DNA recombination%2C of these autonomous mobile genetic elements. The catalytic activity of this enzyme family involves DNA cleavage followed by a strand transfer reaction%3B Belongs to the family 12 of transposase%3B Localized in the cytoplasm%3B~Family membership gene gene990 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_990 ZOBELLIA_991 ZOBELLIA_991 ZOBELLIA_991 1180012 1180365 - Hypothetical protein Probably a cytoplasmic protein gene gene991 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_991 ZOBELLIA_992 ZOBELLIA_992 ZOBELLIA_992 1180654 1181049 + Hypothetical protein Probably localized in the cytoplasm gene gene992 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_992 ZOBELLIA_993 ZOBELLIA_993 ugpQ ugpQ 1181867 1182709 + Glycerophosphoryl diester phosphodiesterase Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols%3B Localized in the cytoplasm%3B~High confidence in function and specificity gene gene993 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_993 ZOBELLIA_994 ZOBELLIA_994 ZOBELLIA_994 1182848 1183426 + RNA polymerase ECF-type sigma factor Sigma factors are initiation factors of transcription that promote the attachment of RNA polymerase to specific initiation sites (promoters) and are then released%3B They alter the specificity of promoter recognition%3B This family represents a group of sigma factors that are able to regulate extra cellular function (ECF). ECF-sigma factors all retain two features: the ability to respond to extra-cytoplasmic functions via the TonB-dependent transducer genes%2C and regulation by anti-sigma and anti-anti-sigma factors%3B~Family membership gene gene994 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_994 ZOBELLIA_995 ZOBELLIA_995 ZOBELLIA_995 1183544 1184665 + Anti-sigma factor This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm%3B Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family%3B The N-terminal domain%2C without similarities%2C would interact with the N-terminal extension found in the TonB-dependant transducers%3B Protein localized in the cytoplasmic membrane%3B~Specificity unclear gene gene995 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_995 ZOBELLIA_996 ZOBELLIA_996 ZOBELLIA_996 1184895 1188341 + TonB-dependent Transducer Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins%3B The presence of an additional N-terminal extension (Secretin/TonB (STN) domain) that probably interacts with an anti-sigma factor%2C would be responsible of the signal transduction%3B Contains a carboxypeptidase regulatory domain (123-197) and a Plug module (214-344) acting as the channel gate%3B The signal peptide is cleaved between the residue 17 and 18%3B~Family membership gene gene996 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_996 ZOBELLIA_997 ZOBELLIA_997 ZOBELLIA_997 1188360 1189838 + Probable SusD/RagB family lipoprotein Protein probably involved in nutrient binding and belonging to the SusD/RagB family%3B Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer%3B Contains a lipoprotein signal peptide cleaved between the residues 18 and 19%3B Probably localized in the outer membrane%3B~Family membership gene gene997 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_997 ZOBELLIA_998 ZOBELLIA_998 ZOBELLIA_998 1189855 1191399 + Type I phosphodiesterase Type I phosphodiesterase catalyzes the cleavage of phosphodiester and phosphosulphate bonds in various compounds such as NAD%2C deoxynucleotides and nucleotide sugars%3B Contains a signal peptide cleaved between the residues 26 and 27%3B Localized in the periplasmic space%3B~Family membership gene gene998 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_998 ZOBELLIA_999 ZOBELLIA_999 ZOBELLIA_999 1191929 1193449 - Sulfatase%2C family S1-23 The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates%3B Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases)%2C subfamily 23%3B Contains a N-terminal transmembrane segment%2C Localized in the cytoplasmic membrane%3B~Family membership gene gene999 http://www.ncbi.nlm.nih.gov/gene/?term=ZOBELLIA_999 rRNA_01 rRNA_01 rRNA_01 1109573 1109686 + rRNA gene924 http://www.ncbi.nlm.nih.gov/gene/?term=rRNA_01 rRNA_02 rRNA_02 rRNA_02 1109842 1112686 + rRNA gene925 http://www.ncbi.nlm.nih.gov/gene/?term=rRNA_02 rRNA_03 rRNA_03 rRNA_03 1113308 1114833 + rRNA gene928 http://www.ncbi.nlm.nih.gov/gene/?term=rRNA_03 rRNA_04 rRNA_04 rRNA_04 3529953 3531478 + rRNA gene3041 http://www.ncbi.nlm.nih.gov/gene/?term=rRNA_04 rRNA_05 rRNA_05 rRNA_05 3532100 3534944 + rRNA gene3044 http://www.ncbi.nlm.nih.gov/gene/?term=rRNA_05 rRNA_06 rRNA_06 rRNA_06 3535100 3535213 + rRNA gene3045 http://www.ncbi.nlm.nih.gov/gene/?term=rRNA_06 tRNA_01 tRNA_01 tRNA_01 596403 596480 + tRNA-Pro Gene encoding for a Proline tRNA with the anticodon sequence UGG (36-38)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene462 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_01 tRNA_010 tRNA_010 tRNA_010 1072110 1072184 + tRNA-Val Gene encoding for a Valine tRNA with the anticodon sequence UAC (36-38)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene901 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_010 tRNA_011 tRNA_011 tRNA_011 1112892 1112968 + tRNA-Ala Gene encoding for a Alanine tRNA with the anticodon sequence UGC (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene926 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_011 tRNA_012 tRNA_012 tRNA_012 1113088 1113164 + tRNA-Ile Gene encoding for a Isoleucine tRNA with the anticodon sequence GAU (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene927 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_012 tRNA_013 tRNA_013 tRNA_013 1178849 1178924 + tRNA-Met Gene encoding for a Methionine tRNA with the anticodon sequence CAU (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene989 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_013 tRNA_014 tRNA_014 tRNA_014 1349374 1349450 + tRNA-Arg Gene encoding for a Arginine tRNA with the anticodon sequence UCU (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino- acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene1129 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_014 tRNA_015 tRNA_015 tRNA_015 1431358 1431433 + tRNA-Phe Gene encoding for a phenylalanine tRNA with the anticodon sequence GAA (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene1200 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_015 tRNA_016 tRNA_016 tRNA_016 1828178 1828254 + tRNA-Ala Gene encoding for a Alanine tRNA with the anticodon sequence GGC (35-37)%3B The tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene1544 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_016 tRNA_017 tRNA_017 tRNA_017 1960463 1960536 + tRNA-Met Gene encoding for a Methionine tRNA with the anticodon sequence CAU (35-37)%3B The tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene1661 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_017 tRNA_018 tRNA_018 tRNA_018 2004795 2004868 + tRNA-Cys Gene encoding for a Cysteine tRNA with the anticodon sequence GCA (33-35)%3B tRNA is the information adapter molecule. It is the direct interface between amino- acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene1702 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_018 tRNA_019 tRNA_019 tRNA_019 2295076 2295152 + tRNA-Asn Gene encoding for a Asparagine tRNA with the anticodon sequence GUU (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene1968 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_019 tRNA_02 tRNA_02 tRNA_02 596512 596598 + tRNA-Ser Gene encoding for a Serine tRNA with the anticodon sequence GCU (33-35)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene463 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_02 tRNA_020 tRNA_020 tRNA_020 2349060 2349134 + tRNA-Arg Gene encoding for a Arginine tRNA with the anticodon sequence CCU (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino- acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2011 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_020 tRNA_021 tRNA_021 tRNA_021 2500549 2500632 + tRNA-Leu Gene encoding for a Leucine tRNA with the anticodon sequence CAA (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene2142 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_021 tRNA_022 tRNA_022 tRNA_022 2548812 2548888 + tRNA-Asp Gene encoding for a Aspartic acid tRNA with the anticodon sequence GUC (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2181 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_022 tRNA_023 tRNA_023 tRNA_023 2673383 2673467 + tRNA-Leu Gene encoding for a Leucine tRNA with the anticodon sequence UAG (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene2289 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_023 tRNA_024 tRNA_024 tRNA_024 2735409 2735499 + tRNA-Ser Gene encoding for a Serine tRNA with the anticodon sequence GGA (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene2331 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_024 tRNA_025 tRNA_025 tRNA_025 2762741 2762815 + tRNA-Gln Gene encoding for a Glutamine tRNA with the anticodon sequence UUG (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2355 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_025 tRNA_026 tRNA_026 tRNA_026 2869347 2869430 + tRNA-Leu Gene encoding for a Leucine tRNA with the anticodon sequence UAA (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene2425 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_026 tRNA_027 tRNA_027 tRNA_027 2887334 2887417 + tRNA-Leu Gene encoding for a Leucine tRNA with the anticodon sequence UAA (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene2436 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_027 tRNA_028 tRNA_028 tRNA_028 2887502 2887577 + Gene encoding for a Glicine tRNA with the anticodon sequence GCC (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2437 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_028 tRNA_029 tRNA_029 tRNA_029 3240277 3240351 + tRNA-Glu Gene encoding for a Glutamic acid tRNA with the anticodon sequence UUC (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2766 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_029 tRNA_03 tRNA_03 tRNA_03 809454 809529 + Gene encoding for a Tryptophane tRNA with the anticodon sequence CCA (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene650 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_03 tRNA_030 tRNA_030 tRNA_030 3240433 3240507 + tRNA-Glu Gene encoding for a Glutamic acid tRNA with the anticodon sequence UUC (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2767 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_030 tRNA_031 tRNA_031 tRNA_031 3256212 3256285 + tRNA-Arg Gene encoding for a Arginine tRNA with the anticodon sequence ACG (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino- acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene2788 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_031 tRNA_032 tRNA_032 tRNA_032 3458622 3458708 + tRNA-Leu Gene encoding for a leucine tRNA with the anticodon sequence GAG (35-37)%3B Contains an additional stem of 5 bases of length%3B The tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene2976 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_032 tRNA_033 tRNA_033 tRNA_033 3499915 3499990 + tRNA-Lys Gene encoding for a Lysine tRNA with the anticodon sequence UUU (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene3011 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_033 tRNA_034 tRNA_034 tRNA_034 3500087 3500162 + tRNA-Lys Gene encoding for a Lysine tRNA with the anticodon sequence UUU (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene3012 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_034 tRNA_035 tRNA_035 tRNA_035 3531622 3531698 + tRNA-Ile Gene encoding for a Isoleucine tRNA with the anticodon sequence GAU (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene3042 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_035 tRNA_036 tRNA_036 tRNA_036 3531818 3531894 + tRNA-Ala Gene encoding for a Alanine tRNA with the anticodon sequence UGC (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene3043 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_036 tRNA_037 tRNA_037 tRNA_037 3690385 3690458 + tRNA-Pro Gene encoding for a Proline tRNA with the anticodon sequence GGG (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene3184 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_037 tRNA_038 tRNA_038 tRNA_038 4658078 4658154 + tRNA-Met Gene encoding for a Methionine tRNA with the anticodon sequence CAU (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene3957 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_038 tRNA_039 tRNA_039 tRNA_039 4714651 4714727 + tRNA-His Gene encoding for a Histidine tRNA with the anticodon sequence GUG (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene4004 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_039 tRNA_04 tRNA_04 tRNA_04 810839 810913 + tRNA-Thr Gene encoding for a Threonine tRNA with the anticodon sequence GGU (33-35)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene652 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_04 tRNA_040 tRNA_040 tRNA_040 4796782 4796869 + tRNA-Ser Gene encoding for a Serine tRNA with the anticodon sequence UGA (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene4083 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_040 tRNA_05 tRNA_05 tRNA_05 810982 811057 + tRNA-Gly Gene encoding for a glycine tRNA with the anticodon sequence UCC (34-36)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene653 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_05 tRNA_06 tRNA_06 tRNA_06 811116 811197 + tRNA-Tyr Gene encoding for a Tyrosine tRNA with the anticodon sequence GUA (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino- acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 2-tRNA tRNA gene654 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_06 tRNA_07 tRNA_07 tRNA_07 811222 811298 + tRNA-Thr Gene encoding for a Threonine tRNA with the anticodon sequence UGU (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene655 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_07 tRNA_08 tRNA_08 tRNA_08 951817 951890 + tRNA-Arg Gene encoding for a Arginine tRNA with the anticodon sequence UCG (35-37)%3B tRNA is the information adapter molecule. It is the direct interface between amino- acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene788 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_08 tRNA_09 tRNA_09 tRNA_09 1069691 1069768 + tRNA-Val Gene encoding for a Valine tRNA with the anticodon sequence GAC (36-38)%3B tRNA is the information adapter molecule. It is the direct interface between amino-acid sequence of a protein and the information in DNA. All have between 75-95 nucleotides%3B The amino acid is attached to the ribose of the terminal adenine residue of the universal sequence CCA at the 3' end of the tRNA%3B Belongs to the class 1-tRNA tRNA gene898 http://www.ncbi.nlm.nih.gov/gene/?term=tRNA_09