locus-tag	class	description
C3497_00010	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
C3497_00015	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
C3497_00025	ENOG4105KCK	Peptidoglycan-associated lipoprotein
C3497_00030	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
C3497_00040	ENOG4105M8F	Biopolymer transport protein exbD tolR
C3497_00045	ENOG4105E02	MotA TolQ exbB proton channel
C3497_00050	ENOG4107YD3	Thioesterase
C3497_00060	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
C3497_00065	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
C3497_00070	ENOG4107RRY	Cyanophycin synthetase
C3497_00075	ENOG4107RRY	Cyanophycin synthetase
C3497_00080	ENOG4105BZ1	(ABC) transporter
C3497_00095	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
C3497_00100	ENOG4105C11	sulfate adenylyltransferase), subunit 2
C3497_00115	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
C3497_00120	ENOG4107R11	Transcriptional regulator
C3497_00125	ENOG4105HDK	L-asparaginase
C3497_00130	ENOG4108IJ0	Aspartate ammonia-lyase
C3497_00135	ENOG4108JJ7	ABC transporter
C3497_00155	ENOG4107QPN	acyl-Coa dehydrogenase
C3497_00160	ENOG4105CHU	acetyl-coa acetyltransferase
C3497_00170	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
C3497_00180	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
C3497_00190	ENOG4105CHU	acetyl-coa acetyltransferase
C3497_00205	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C3497_00210	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C3497_00220	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
C3497_00225	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
C3497_00230	ENOG4105CGU	Enoyl-CoA hydratase
C3497_00255	ENOG41085EG	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
C3497_00260	ENOG4105KME	endoribonuclease L-psp
C3497_00265	ENOG4105CB5	ATP-dependent DNA helicase recG
C3497_00270	ENOG4105RUM	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
C3497_00275	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
C3497_00280	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
C3497_00295	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
C3497_00320	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
C3497_00330	ENOG4105XQ6	frataxin-like protein
C3497_00335	ENOG4108JQC	penicillin-binding protein 1A
C3497_00360	ENOG4105E4G	Type IV pilus
C3497_00365	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
C3497_00370	ENOG4105D49	3-dehydroquinate synthase
C3497_00375	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
C3497_00390	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
C3497_00400	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
C3497_00445	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
C3497_00450	ENOG4105C32	Amino acid ABC transporter (Permease)
C3497_00455	ENOG4105EA8	2-Nitropropane dioxygenase
C3497_00460	ENOG4105EN6	Membrane
C3497_00490	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
C3497_00495	ENOG4108YXG	UPF0502 protein
C3497_00500	ENOG4105C01	Dihydroxy-acid dehydratase
C3497_00515	ENOG4105CC5	ABC transporter
C3497_00520	ENOG4105DIK	(ABC) transporter
C3497_00525	ENOG4105MYN	Zinc uptake regulation protein
C3497_00535	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C3497_00550	ENOG4105CEN	a g-specific adenine glycosylase
C3497_00570	ENOG4108A51	
C3497_00575	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
C3497_00585	ENOG4108JJB	ABC transporter
C3497_00590	ENOG4105MRR	Transcriptional regulator (By similarity)
C3497_00595	ENOG4105BZU	Histidine kinase
C3497_00600	ENOG4105DPX	Hydrogenase, large subunit
C3497_00605	ENOG4105E3S	small subunit
C3497_00610	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_00625	ENOG4105F71	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
C3497_00650	ENOG4107RSS	Hydrogenase accessory protein HypB
C3497_00655	ENOG41081J6	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
C3497_00670	ENOG410631X	Hydrogenase expression formation protein
C3497_00675	ENOG4108UT5	Hydrogenase expression
C3497_00680	ENOG4105YYZ	Hydrogenase expression formation protein
C3497_00690	ENOG4108USZ	hydrogenase
C3497_00700	ENOG4105DPX	Hydrogenase, large subunit
C3497_00705	ENOG4105E3S	small subunit
C3497_00715	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C3497_00725	ENOG4105DMF	Dehydrogenase
C3497_00735	ENOG4105DND	Transcriptional regulator
C3497_00750	ENOG4105BZU	Histidine kinase
C3497_00755	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C3497_00760	ENOG4105BZU	Histidine kinase
C3497_00770	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C3497_00775	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C3497_00790	ENOG4108UKI	Enoyl-CoA hydratase
C3497_00795	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
C3497_00800	ENOG4108ZJI	phenylacetic acid degradation protein
C3497_00810	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
C3497_00815	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
C3497_00820	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
C3497_00825	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
C3497_00830	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
C3497_00840	ENOG4105CHU	acetyl-coa acetyltransferase
C3497_00855	ENOG4105C0Z	ABC transporter
C3497_00860	ENOG4108IV0	ABC, transporter
C3497_00875	ENOG4105C1J	atp-dependent rna helicase
C3497_00880	ENOG4107YIM	Involved in the transcription termination process (By similarity)
C3497_00885	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
C3497_00890	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
C3497_00900	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
C3497_00910	ENOG4108U78	Glutathione S-transferase
C3497_00915	ENOG4107U2T	alpha beta
C3497_00930	ENOG4105XPQ	lipid carrier protein
C3497_00935	ENOG4106RZ4	Peptidase U32
C3497_00940	ENOG4105CFP	Peptidase U32
C3497_00950	ENOG4105C8Y	Acetylornithine aminotransferase
C3497_00960	ENOG4105C75	arginyL-tRNA synthetase
C3497_00970	ENOG4108Z33	Thiol disulfide Interchange Protein
C3497_00990	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
C3497_01005	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
C3497_01010	ENOG4105QAX	Iron-sulfur
C3497_01015	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
C3497_01040	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
C3497_01055	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
C3497_01065	ENOG4108Z6Z	Transcriptional regulator
C3497_01075	ENOG4105C1G	acyl-Coa dehydrogenase
C3497_01080	ENOG4105CHU	acetyl-coa acetyltransferase
C3497_01085	ENOG4105C1G	acyl-Coa dehydrogenase
C3497_01095	ENOG4108R6W	Transcriptional regulator, ARAC family
C3497_01100	ENOG4107QX3	carboxylase
C3497_01115	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
C3497_01135	ENOG4105BZG	amino acid carrier protein
C3497_01140	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
C3497_01155	ENOG4105DHQ	Histidine kinase
C3497_01160	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
C3497_01170	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
C3497_01180	ENOG4105VBA	Cytochrome
C3497_01190	ENOG4105E3J	oxidoreductase
C3497_01195	ENOG4105C6T	cysteine synthase
C3497_01200	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
C3497_01205	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
C3497_01215	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_01220	ENOG4108V3W	Chemotaxis protein, CheW
C3497_01225	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_01230	ENOG4105CBS	Chea signal transduction histidine kinase
C3497_01240	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_01245	ENOG4108VYJ	response regulator receiver protein
C3497_01250	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
C3497_01255	ENOG4105K8R	UPF0145 protein
C3497_01265	ENOG4105CDY	transcriptional regulatory protein
C3497_01275	ENOG4105D7A	ATP-binding protein
C3497_01285	ENOG4105SYT	Methylenetetrahydrofolate reductase
C3497_01290	ENOG4105DX0	Hemolysin A
C3497_01295	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
C3497_01305	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
C3497_01315	ENOG4105D1S	lipid A biosynthesis
C3497_01325	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
C3497_01335	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C3497_01360	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
C3497_01370	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
C3497_01380	ENOG4105C03	ribonuclease
C3497_01385	ENOG4108Z03	MAF-like protein
C3497_01390	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
C3497_01395	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
C3497_01400	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
C3497_01415	ENOG4105CUV	Homoserine Kinase
C3497_01425	ENOG4108URH	decarboxylase
C3497_01430	ENOG4105C2M	dna polymerase I
C3497_01440	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
C3497_01450	ENOG4107QQG	Dehydrogenase
C3497_01455	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
C3497_01465	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C3497_01470	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
C3497_01475	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
C3497_01495	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
C3497_01505	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
C3497_01510	ENOG4105BZ9	Cytochrome C oxidase, subunit I
C3497_01515	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
C3497_01525	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
C3497_01530	ENOG4105EFT	decarboxylase
C3497_01535	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
C3497_01540	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
C3497_01575	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
C3497_01580	ENOG4105C1G	acyl-Coa dehydrogenase
C3497_01590	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_01620	ENOG41060WC	Enoyl-CoA hydratase
C3497_01625	ENOG4105C37	(CBS) domain
C3497_01630	ENOG4105DRR	Transcriptional regulator, GntR family
C3497_01635	ENOG4105D5P	Methylmalonyl-coA mutase
C3497_01640	ENOG4105DJT	lAO AO transport system ATPase
C3497_01645	ENOG4107QX3	carboxylase
C3497_01650	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
C3497_01655	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
C3497_01665	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C3497_01670	ENOG4105CQZ	Histidine kinase
C3497_01680	ENOG4105D5P	Methylmalonyl-coA mutase
C3497_01685	ENOG4105BZU	Histidine kinase
C3497_01690	ENOG4108IQE	Amp-dependent synthetase and ligase
C3497_01695	ENOG4105C0Z	ABC transporter
C3497_01700	ENOG4105C32	Amino acid ABC transporter (Permease)
C3497_01715	ENOG4108IV0	ABC, transporter
C3497_01725	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
C3497_01735	ENOG4105BZU	Histidine kinase
C3497_01745	ENOG4108W5X	Transcriptional Regulator, LuxR family
C3497_01755	ENOG4107EPK	O-methyltransferase, family 2
C3497_01765	ENOG4105CQB	FAD linked oxidase domain protein
C3497_01785	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C3497_01795	ENOG4105PM1	preprotein translocase subunit SecE
C3497_01805	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
C3497_01810	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
C3497_01815	ENOG4108VZM	50s ribosomal protein L10
C3497_01820	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
C3497_01825	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C3497_01830	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C3497_01835	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
C3497_01840	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
C3497_01845	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C3497_01850	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C3497_01855	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
C3497_01860	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
C3497_01865	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
C3497_01870	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
C3497_01875	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3497_01880	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
C3497_01885	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
C3497_01890	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
C3497_01895	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
C3497_01900	ENOG41083MP	50s ribosomal protein l29
C3497_01905	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
C3497_01910	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
C3497_01915	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
C3497_01920	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3497_01925	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
C3497_01930	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
C3497_01935	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
C3497_01940	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
C3497_01945	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
C3497_01950	ENOG4105VPB	50S ribosomal protein L30
C3497_01955	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
C3497_01960	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
C3497_01965	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
C3497_01970	ENOG41067V7	50S ribosomal protein L36
C3497_01975	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3497_01980	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
C3497_01985	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
C3497_01990	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C3497_01995	ENOG4108ZT0	50S ribosomal protein l17
C3497_02000	ENOG4105CMR	udp-glucose 4-epimerase
C3497_02015	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C3497_02020	ENOG4107RDB	Major Facilitator
C3497_02025	ENOG4108UUM	single-stranded DNA-binding protein
C3497_02030	ENOG4105CVR	type I restriction-modification system
C3497_02035	ENOG4105EKX	Restriction modification system DNA (Specificity
C3497_02045	ENOG4105DZR	Type I site-specific deoxyribonuclease
C3497_02050	ENOG4105C87	Aminotransferase class I and II
C3497_02060	ENOG4105CUZ	uba thif-type nad fad binding protein
C3497_02075	ENOG4105BZS	acriflavin resistance protein
C3497_02090	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
C3497_02095	ENOG4105W2Z	cytochrome C, class I
C3497_02100	ENOG4105BZU	Histidine kinase
C3497_02105	ENOG4105CUX	Signal transduction histidine kinase
C3497_02110	ENOG4105D58	Diguanylate phosphodiesterase
C3497_02115	ENOG4108EX3	reductase
C3497_02125	ENOG4108YXA	Membrane
C3497_02130	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
C3497_02135	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
C3497_02140	ENOG4105CZX	twitching motility protein
C3497_02145	ENOG4105CZX	twitching motility protein
C3497_02150	ENOG4105DFA	alanine racemase domain protein
C3497_02155	ENOG4105II7	pyrroline-5-carboxylate reductase
C3497_02160	ENOG4108VIA	integral membrane protein
C3497_02165	ENOG4105VZ9	UPF0235 protein
C3497_02180	ENOG4105CD3	dihydroorotase
C3497_02185	ENOG4105CXT	aspartate transcarbamylase
C3497_02190	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
C3497_02195	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
C3497_02200	ENOG4108UJU	UPF0301 protein
C3497_02205	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
C3497_02210	ENOG4105CBS	Chea signal transduction histidine kinase
C3497_02215	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_02220	ENOG4108V3W	Chemotaxis protein, CheW
C3497_02225	ENOG4105M3Z	response regulator
C3497_02230	ENOG4108UNF	response regulator
C3497_02235	ENOG4105VCQ	rubredoxin
C3497_02245	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
C3497_02250	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
C3497_02255	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
C3497_02260	ENOG4105T95	Thiol disulfide interChange protein
C3497_02265	ENOG4105CA3	membrane-bound lytic murein transglycosylase
C3497_02275	ENOG4105M6F	mutator MutT protein
C3497_02280	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
C3497_02285	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
C3497_02290	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
C3497_02300	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
C3497_02305	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
C3497_02310	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
C3497_02315	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C3497_02320	ENOG4105CUX	Signal transduction histidine kinase
C3497_02330	ENOG4105C5F	glutamine synthetase
C3497_02345	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
C3497_02355	ENOG4105G2U	Cupin 2, conserved barrel domain protein
C3497_02360	ENOG4107T6J	Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit
C3497_02365	ENOG4105X23	Endonuclease Exonuclease phosphatase
C3497_02370	ENOG4105DZQ	phospholipase D Transphosphatidylase
C3497_02375	ENOG4105K4P	CoA-binding domain protein
C3497_02380	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
C3497_02400	ENOG4105W1Y	Transcriptional regulator
C3497_02415	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
C3497_02420	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
C3497_02460	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
C3497_02475	ENOG4105DZR	Type I site-specific deoxyribonuclease
C3497_02480	ENOG4105ESI	atpase involved in dna repair
C3497_02485	ENOG4105CB5	ATP-dependent DNA helicase recG
C3497_02490	ENOG41082EK	Restriction modification system DNA (Specificity
C3497_02520	ENOG4105DFP	Integrase
C3497_02525	ENOG4105C3G	gtp-binding protein
C3497_02530	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
C3497_02535	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
C3497_02540	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
C3497_02550	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
C3497_02555	ENOG41081V9	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
C3497_02560	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
C3497_02565	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
C3497_02570	ENOG410890F	Dynamin family
C3497_02575	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
C3497_02580	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
C3497_02585	ENOG4106H78	methyltransferase
C3497_02590	ENOG4105C1V	Peptidase, M16
C3497_02605	ENOG4105CAK	Cell division ATP-binding protein ftsE
C3497_02610	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
C3497_02620	ENOG4108JU3	Alkyl hydroperoxide reductase
C3497_02625	ENOG4105BZ1	(ABC) transporter
C3497_02635	ENOG4107QTF	adenylosuccinate lyase
C3497_02645	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C3497_02655	ENOG4105VIE	preprotein translocase, subunit YajC
C3497_02665	ENOG4105D01	(LipO)protein
C3497_02670	ENOG4108UMI	ABC transporter, permease
C3497_02680	ENOG4108IV0	ABC, transporter
C3497_02685	ENOG4105C0Z	ABC transporter
C3497_02690	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
C3497_02695	ENOG4105C32	Amino acid ABC transporter (Permease)
C3497_02700	ENOG4105CP9	extracellular ligand-binding receptor
C3497_02705	ENOG4105C26	Dehydrogenase
C3497_02710	ENOG4105EW9	transcriptional regulator AsnC family
C3497_02715	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
C3497_02720	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
C3497_02730	ENOG41063Z6	transcriptional regulator, lysR family
C3497_02740	ENOG4108MN8	Membrane
C3497_02745	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
C3497_02750	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
C3497_02755	ENOG4108ZXC	Two component transcriptional regulator, luxr family
C3497_02760	ENOG4105BZU	Histidine kinase
C3497_02765	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
C3497_02770	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
C3497_02785	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
C3497_02790	ENOG4105CUT	histidyl-tRNA synthetase
C3497_02800	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
C3497_02805	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
C3497_02810	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
C3497_02815	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
C3497_02820	ENOG4107QJR	hflk protein
C3497_02825	ENOG4105EPW	hflc protein
C3497_02835	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
C3497_02840	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
C3497_02860	ENOG4105C2N	RNA methyltransferase TrmH family group 3
C3497_02880	ENOG4105D7T	ABC transporter
C3497_02885	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
C3497_02890	ENOG4108IFG	nitrite reductase, (NAD(P)H)
C3497_02905	ENOG41063Z6	transcriptional regulator, lysR family
C3497_02920	ENOG4108DBC	nitroreductase
C3497_02935	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
C3497_02940	ENOG4107QMP	dna polymerase iii subunits gamma and tau
C3497_02945	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
C3497_02950	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
C3497_02955	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C3497_02960	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C3497_02965	ENOG4105EIX	cytochrome c1
C3497_02970	ENOG4107MKT	Stringent starvation protein a
C3497_02975	ENOG4105KB2	stringent starvation protein b
C3497_02980	ENOG4105BZF	Glycosyl transferase (Group 1
C3497_02985	ENOG4105Y3Q	hemerythrin-like, metal-binding protein
C3497_02995	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
C3497_03000	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C3497_03010	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
C3497_03015	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C3497_03020	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C3497_03025	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
C3497_03030	ENOG4105DHQ	Histidine kinase
C3497_03040	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
C3497_03055	ENOG4108IUW	ABC transporter
C3497_03065	ENOG4105J0Q	Transcriptional regulator
C3497_03070	ENOG4105E4C	Lytic transglycosylase catalytic
C3497_03075	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
C3497_03080	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
C3497_03095	ENOG4105C8J	)-transporter
C3497_03100	ENOG4108YXU	transcriptional regulator AsnC family
C3497_03120	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
C3497_03125	ENOG4108RA0	tripartite ATP-independent periplasmic transporter, DctQ component
C3497_03130	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
C3497_03135	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
C3497_03155	ENOG4108WBT	adenosyltransferase
C3497_03160	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
C3497_03165	ENOG4105BZU	Histidine kinase
C3497_03175	ENOG4105DNZ	Alpha Beta Hydrolase
C3497_03190	ENOG4105CM2	brancheD-chain amino acid aminotransferase
C3497_03210	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
C3497_03230	ENOG4105I7R	Adenylate cyclase
C3497_03235	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
C3497_03240	ENOG4105QD6	exported protein
C3497_03250	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
C3497_03270	ENOG4105E0F	Histidine kinase
C3497_03275	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C3497_03285	ENOG4108I9X	Isocitrate lyase
C3497_03290	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
C3497_03295	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C3497_03300	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
C3497_03305	ENOG4105VEQ	Cold shock protein
C3497_03310	ENOG4105W0E	50S ribosomal protein L33
C3497_03315	ENOG4105KDC	50s ribosomal protein l28
C3497_03320	ENOG4105W5Q	DNA repair protein (RadC
C3497_03325	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
C3497_03330	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
C3497_03340	ENOG4107S7U	Sulfide dehydrogenase
C3497_03360	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
C3497_03365	ENOG4108HMX	isocitrate dehydrogenase (NADP)
C3497_03370	ENOG4107YZX	Universal stress protein
C3497_03380	ENOG4107QN1	sodium solute
C3497_03395	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C3497_03410	ENOG4108ZG0	Ompa motb domain protein
C3497_03415	ENOG4105BZU	Histidine kinase
C3497_03435	ENOG4105CA9	Pyruvate kinase
C3497_03450	ENOG4105BZA	Phosphoglycerate kinase
C3497_03455	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C3497_03460	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C3497_03465	ENOG4105CV1	Transketolase (EC 2.2.1.1)
C3497_03480	ENOG4105ECY	inositol monophosphatase
C3497_03485	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
C3497_03490	ENOG4105CSR	polyphosphate kinase 2
C3497_03495	ENOG4108EKC	n-acetylglutamate synthase
C3497_03500	ENOG4105BZU	Histidine kinase
C3497_03505	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
C3497_03510	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
C3497_03515	ENOG4105E66	phosphoriboisomerase A
C3497_03520	ENOG4105ED9	Protein of unknown function (DUF455)
C3497_03525	ENOG4105CRE	cytochrome C
C3497_03530	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
C3497_03540	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
C3497_03545	ENOG4105D52	delta-aminolevulinic acid dehydratase
C3497_03560	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
C3497_03565	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
C3497_03570	ENOG4105MJ2	Competence protein
C3497_03575	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
C3497_03580	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
C3497_03590	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
C3497_03595	ENOG4105VW4	glutaredoxin 3
C3497_03600	ENOG4107YZP	Rhodanese domain protein
C3497_03605	ENOG41080HT	Transcriptional regulator, arsr family
C3497_03610	ENOG41063SB	peptidase
C3497_03615	ENOG4105CN1	protease
C3497_03625	ENOG4105D06	uba thif-type nad fad binding protein
C3497_03630	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
C3497_03635	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
C3497_03640	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
C3497_03645	ENOG4105CVJ	phosphoglycerate mutase
C3497_03650	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
C3497_03660	ENOG4105CH5	extracellular solute-binding protein, family 7
C3497_03665	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
C3497_03670	ENOG4105N42	UPF0307 protein
C3497_03675	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
C3497_03680	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
C3497_03685	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
C3497_03690	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
C3497_03695	ENOG4105DHT	Metal Dependent Phosphohydrolase
C3497_03700	ENOG4108R99	pseudouridine synthase
C3497_03710	ENOG4105D00	flagellar biosynthetic protein flhB
C3497_03715	ENOG4105D7B	Flagellar biosynthesis protein flha
C3497_03720	ENOG4105BZU	Histidine kinase
C3497_03725	ENOG4105FZW	flagellar biosynthesis regulator FlhF
C3497_03735	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C3497_03740	ENOG4105E14	MotA TolQ exbB proton channel
C3497_03745	ENOG4105ER2	Ompa motb domain protein
C3497_03755	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
C3497_03760	ENOG4108UKZ	OsmC family
C3497_03765	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
C3497_03770	ENOG4108UJD	30S ribosomal protein S9
C3497_03775	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
C3497_03780	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
C3497_03785	ENOG4105DR5	peptidase
C3497_03790	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
C3497_03825	ENOG4108Z7G	MaoC domain protein dehydratase
C3497_03830	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
C3497_03835	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
C3497_03840	ENOG4105CTB	Polyprenyl synthetase
C3497_03845	ENOG41082UU	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C3497_03855	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
C3497_03860	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
C3497_03865	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
C3497_03870	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
C3497_03875	ENOG4105DTN	riboflavin biosynthesis protein ribF
C3497_03880	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
C3497_03885	ENOG4105K8N	protein family UPF0079, ATPase
C3497_03890	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
C3497_03905	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
C3497_03915	ENOG4105C34	Pseudouridine synthase
C3497_03920	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
C3497_03930	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
C3497_03935	ENOG4105CHR	reductase
C3497_03945	ENOG4108NVM	synthesis repressor PhaR
C3497_03950	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
C3497_03955	ENOG4105D78	K07001 NTE family protein
C3497_03960	ENOG4105CQB	FAD linked oxidase domain protein
C3497_03995	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
C3497_04000	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
C3497_04005	ENOG4105K63	Thioredoxin
C3497_04010	ENOG4108Z4U	Ferredoxin
C3497_04020	ENOG4105CEY	Amp-dependent synthetase and ligase
C3497_04025	ENOG4105C7K	acetolactate synthase
C3497_04030	ENOG4105M71	acetolactate synthase 1 regulatory subunit
C3497_04035	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
C3497_04040	ENOG4105D8G	Major Facilitator superfamily
C3497_04045	ENOG4108K0D	peptidase, M48
C3497_04050	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C3497_04055	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C3497_04060	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
C3497_04065	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
C3497_04080	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
C3497_04085	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
C3497_04090	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
C3497_04095	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
C3497_04100	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
C3497_04105	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
C3497_04120	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
C3497_04125	ENOG4105C28	cystathionine
C3497_04130	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
C3497_04135	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C3497_04140	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C3497_04155	ENOG4105C8N	cysteinyl-tRNA synthetase
C3497_04165	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
C3497_04170	ENOG4105CFG	Acts as a chaperone (By similarity)
C3497_04175	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3497_04190	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
C3497_04195	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
C3497_04200	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
C3497_04205	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
C3497_04210	ENOG41090R7	Ferric uptake
C3497_04215	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
C3497_04220	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
C3497_04225	ENOG4105BZU	Histidine kinase
C3497_04235	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
C3497_04240	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
C3497_04250	ENOG4105HBR	Rna-binding protein
C3497_04255	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
C3497_04260	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C3497_04270	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
C3497_04280	ENOG4105C8U	phosphate abc transporter
C3497_04285	ENOG4105C8U	phosphate abc transporter
C3497_04290	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C3497_04295	ENOG4107SDU	Methyl-accepting chemotaxis
C3497_04310	ENOG4107S21	permease
C3497_04320	ENOG4105I6B	RNA polymerase
C3497_04325	ENOG4105D6J	arsenicaL-resistance protein
C3497_04345	ENOG4108UXE	Protein tyrosine phosphatase
C3497_04350	ENOG41085FC	arsR family transcriptional regulator
C3497_04370	ENOG410600T	transposase
C3497_04375	ENOG4105CP7	Triose-phosphate isomerase
C3497_04380	ENOG4107EJC	Preprotein translocase subunit SecG
C3497_04390	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3497_04395	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C3497_04400	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3497_04405	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C3497_04415	ENOG4107QIZ	NADH dehydrogenase
C3497_04420	ENOG4108IEH	NADH dehydrogenase subunit g
C3497_04425	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
C3497_04430	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C3497_04435	ENOG4105DF2	NADH dehydrogenase subunit j
C3497_04440	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C3497_04445	ENOG4105D65	subunit l
C3497_04450	ENOG4105C8S	subunit m
C3497_04455	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C3497_04470	ENOG4105K59	histidine triad (HIT) protein
C3497_04510	ENOG4105PGM	cation diffusion facilitator family transporter
C3497_04525	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
C3497_04545	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
C3497_04555	ENOG4105BZU	Histidine kinase
C3497_04565	ENOG4105W3S	hemerythrin-like, metal-binding protein
C3497_04570	ENOG4105BZU	Histidine kinase
C3497_04585	ENOG4105BZU	Histidine kinase
C3497_04590	ENOG4107TSX	ABC branched chain amino acid family transporter periplasmic ligand binding protein
C3497_04595	ENOG4105C32	Amino acid ABC transporter (Permease)
C3497_04600	ENOG4105CNN	ABC, transporter
C3497_04605	ENOG4105C0Z	ABC transporter
C3497_04625	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C3497_04640	ENOG4105E4C	Lytic transglycosylase catalytic
C3497_04660	ENOG4105C5H	ABC transporter
C3497_04670	ENOG41085FR	LemA family
C3497_04675	ENOG4105DCM	major facilitator superfamily
C3497_04685	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
C3497_04690	ENOG4105CBS	Chea signal transduction histidine kinase
C3497_04695	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C3497_04700	ENOG4105D65	subunit l
C3497_04705	ENOG4108ZE9	Monovalent cation H antiporter subunit C
C3497_04710	ENOG4108JPZ	Monovalent cation H antiporter subunit D
C3497_04715	ENOG4105SC1	monovalent cation H antiporter subunit E
C3497_04720	ENOG41080TA	Multiple resistance and ph regulation protein f
C3497_04725	ENOG4105KJM	monovalent cation h antiporter subunit g
C3497_04760	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
C3497_04765	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3497_04770	ENOG4105K46	50S ribosomal protein l27
C3497_04775	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
C3497_04780	ENOG4105CHH	sulfate transporter
C3497_04785	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
C3497_04790	ENOG4105CQB	FAD linked oxidase domain protein
C3497_04795	ENOG4105EU8	FAD linked oxidase domain protein
C3497_04800	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
C3497_04805	ENOG4108ZF3	Phosphatase
C3497_04810	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
C3497_04815	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
C3497_04820	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
C3497_04830	ENOG4105BZU	Histidine kinase
C3497_04850	ENOG4105C1J	atp-dependent rna helicase
C3497_04855	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
C3497_04860	ENOG4105CPC	Aldo Keto reductase
C3497_04875	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
C3497_04880	ENOG4105EAH	synthase
C3497_04890	ENOG4105C7B	Threonine dehydratase
C3497_04905	ENOG4105K4H	Nlp p60 protein
C3497_04910	ENOG4105F2I	Transposase
C3497_04925	ENOG4108IAB	Phoh family
C3497_04930	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3497_04940	ENOG4105CHM	Aminotransferase
C3497_04945	ENOG4105D6E	homoserine dehydrogenase
C3497_04950	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
C3497_04965	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
C3497_04970	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C3497_04975	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
C3497_04980	ENOG4105BZU	Histidine kinase
C3497_04985	ENOG4105ED1	spovr family
C3497_05005	ENOG4105CYN	Serine protein kinase
C3497_05010	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
C3497_05015	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
C3497_05020	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
C3497_05050	ENOG4105P8F	nudix hydrolase
C3497_05055	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
C3497_05070	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
C3497_05075	ENOG4105CKW	Inner membrane protein yedI
C3497_05080	ENOG4105CRK	lysyL-tRNA synthetase
C3497_05085	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_05090	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
C3497_05105	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
C3497_05125	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
C3497_05140	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C3497_05145	ENOG4107SDU	Methyl-accepting chemotaxis
C3497_05155	ENOG4108EC8	DNA internalization-related competence protein ComEC
C3497_05165	ENOG4105E0X	reductase
C3497_05175	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
C3497_05185	ENOG4105DR5	peptidase
C3497_05200	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
C3497_05225	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
C3497_05235	ENOG41082UD	thioesterase Superfamily protein
C3497_05240	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C3497_05250	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
C3497_05255	ENOG4105CHV	Transcription elongation factor NusA
C3497_05260	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
C3497_05265	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
C3497_05270	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
C3497_05275	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
C3497_05280	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
C3497_05285	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3497_05315	ENOG4108IJ0	Aspartate ammonia-lyase
C3497_05320	ENOG4105HDK	L-asparaginase
C3497_05325	ENOG4105MPD	Cytochrome
C3497_05350	ENOG4108T0W	nitrous oxide maturation protein NosY
C3497_05355	ENOG4105CIG	ABC transporter
C3497_05360	ENOG4105DH4	Periplasmic copper-binding protein
C3497_05370	ENOG4105HEE	Binding Domain protein
C3497_05380	ENOG4105TX3	Histidine kinase
C3497_05385	ENOG4108UYB	regulatoR
C3497_05400	ENOG4105CGF	Aromatic amino acid aminotransferase
C3497_05405	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
C3497_05415	ENOG4105C03	ribonuclease
C3497_05420	ENOG4105EI2	Pseudouridine synthase
C3497_05430	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
C3497_05435	ENOG4108UHJ	MAF-like protein
C3497_05440	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
C3497_05445	ENOG4105VGS	50s ribosomal protein l32
C3497_05450	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
C3497_05455	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
C3497_05460	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
C3497_05465	ENOG4105CHR	reductase
C3497_05470	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
C3497_05475	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
C3497_05485	ENOG4108IYU	L-aspartate oxidase
C3497_05490	ENOG4105EMN	RNA polymerase sigma factor
C3497_05500	ENOG4105VQK	sigma E regulatory protein, MucB RseB
C3497_05510	ENOG4105C0H	protease
C3497_05520	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
C3497_05525	ENOG4105C3F	Signal peptidase i
C3497_05535	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
C3497_05540	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
C3497_05545	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
C3497_05550	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
C3497_05555	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
C3497_05560	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
C3497_05565	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
C3497_05570	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
C3497_05585	ENOG4105DIJ	Phosphoethanolamine transferase
C3497_05620	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
C3497_05630	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
C3497_05635	ENOG4108NIW	Leucine export protein LeuE
C3497_05640	ENOG4105F2I	Transposase
C3497_05665	ENOG4105CS1	NAD(P)H quinone oxidoreductase
C3497_05675	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C3497_05680	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
C3497_05685	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
C3497_05690	ENOG4108ZP8	Acetolactate synthase small subunit
C3497_05695	ENOG4105C7K	acetolactate synthase
C3497_05710	ENOG4105CD8	aminopeptidase N
C3497_05720	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
C3497_05725	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
C3497_05740	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3497_05745	ENOG4105DJ0	Poly(A) Polymerase
C3497_05750	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
C3497_05755	ENOG4107QMS	site-determining protein
C3497_05760	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
C3497_05770	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
C3497_05775	ENOG4105KUZ	arsenate reductase
C3497_05785	ENOG4105DSB	aldose 1-epimerase
C3497_05790	ENOG4105CD5	CoA-binding domain protein
C3497_05800	ENOG4108N3W	hemolysin secretion protein
C3497_05805	ENOG4105C26	Dehydrogenase
C3497_05815	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
C3497_05825	ENOG4108UJV	acyl-CoA thioesterase i
C3497_05830	ENOG4108I0Y	(ABC) transporter
C3497_05845	ENOG4105EIN	peptidylprolyl cis-trans isomerase
C3497_05850	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_05855	ENOG4105BZU	Histidine kinase
C3497_05865	ENOG4105BZU	Histidine kinase
C3497_05870	ENOG4107QUY	Guanine deaminase
C3497_05885	ENOG4105UIB	(ABC) transporter
C3497_05890	ENOG4108JQ9	ABC transporter
C3497_05905	ENOG4105BZU	Histidine kinase
C3497_05910	ENOG4105BZU	Histidine kinase
C3497_05915	ENOG4105GEH	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity)
C3497_05920	ENOG4106CIA	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region
C3497_05925	ENOG4107RD7	Flagellar Motor Protein, MotA
C3497_05930	ENOG4105ER2	Ompa motb domain protein
C3497_05935	ENOG4105CBS	Chea signal transduction histidine kinase
C3497_05940	ENOG4105CBS	Chea signal transduction histidine kinase
C3497_05945	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_05950	ENOG4105BZU	Histidine kinase
C3497_05955	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
C3497_05960	ENOG4107R88	Chemotaxis protein (CheV)
C3497_05965	ENOG4107R88	Chemotaxis protein (CheV)
C3497_05970	ENOG4108VYJ	response regulator receiver protein
C3497_05975	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
C3497_05980	ENOG4105CBS	Chea signal transduction histidine kinase
C3497_05990	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
C3497_05995	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
C3497_06005	ENOG4105C8Y	Acetylornithine aminotransferase
C3497_06010	ENOG4105DBV	ornithine carbamoyltransferase
C3497_06015	ENOG4105CDH	Citrulline--aspartate ligase
C3497_06025	ENOG4105NBK	UPF0345 protein
C3497_06030	ENOG4108VPT	UPF0234 protein
C3497_06035	ENOG4105D0M	Protease HtpX homolog
C3497_06040	ENOG4105VN1	Heat shock protein
C3497_06055	ENOG4105BZU	Histidine kinase
C3497_06060	ENOG4108Z6B	deaminase
C3497_06065	ENOG4108QQZ	ErfK YbiS YcfS YnhG family protein
C3497_06085	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
C3497_06090	ENOG4105HHA	aminodeoxychorismate lyase
C3497_06095	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
C3497_06100	ENOG4107QRG	dna polymerase iii
C3497_06110	ENOG4105F8V	Hydrolase, tatD family
C3497_06125	ENOG4107S7U	Sulfide dehydrogenase
C3497_06130	ENOG4108S1R	peptidylprolyl cis-trans isomerase
C3497_06135	ENOG4105XV5	nifz family
C3497_06140	ENOG410605C	May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity)
C3497_06150	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C3497_06155	ENOG4105C3J	Cysteine desulfurase
C3497_06160	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
C3497_06165	ENOG4105QAS	Iron-sulfur cluster assembly accessory protein
C3497_06175	ENOG4105WCA	Ferredoxin
C3497_06195	ENOG4108UR2	Nitrogen fixation protein NifX
C3497_06200	ENOG4105DK8	Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN
C3497_06205	ENOG4105D0B	Nitrogenase protein alpha chain
C3497_06220	ENOG4105VDB	UPF0125 protein
C3497_06225	ENOG4108E8M	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
C3497_06230	ENOG4108UQQ	Electron transport complex
C3497_06235	ENOG4105D6A	Electron transport complex
C3497_06240	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
C3497_06245	ENOG4108R3D	Electron transport complex
C3497_06250	ENOG4105DGN	Electron transport complex
C3497_06255	ENOG4105DS4	PAS PAC sensor Signal transduction histidine kinase
C3497_06260	ENOG4108JUA	Transcriptional regulator
C3497_06265	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
C3497_06280	ENOG41065RQ	ADP-ribosylation crystallin J1
C3497_06285	ENOG4105FZE	dinitrogenase iron-molybdenum cofactor biosynthesis
C3497_06290	ENOG4107IVC	4Fe-4S ferredoxin, iron-sulfur binding
C3497_06295	ENOG41084IN	nitrogen fixation protein
C3497_06300	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
C3497_06305	ENOG4105D0B	Nitrogenase protein alpha chain
C3497_06310	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
C3497_06315	ENOG4108K8Z	nad( )--dinitrogen-reductase ADP-d-ribosyltransferase
C3497_06330	ENOG4105CHH	sulfate transporter
C3497_06335	ENOG4105BZU	Histidine kinase
C3497_06370	ENOG4105CH2	amidohydrolase
C3497_06375	ENOG4105CV6	ABC transporter, permease
C3497_06380	ENOG4105BZU	Histidine kinase
C3497_06390	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C3497_06400	ENOG4105EAC	phosphoserine phosphatase
C3497_06405	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
C3497_06410	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
C3497_06420	ENOG4105E5H	Transposase
C3497_06435	ENOG4107JHD	SlyX family
C3497_06440	ENOG4105CFP	Peptidase U32
C3497_06445	ENOG4105W3S	hemerythrin-like, metal-binding protein
C3497_06455	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
C3497_06460	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
C3497_06465	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
C3497_06470	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
C3497_06480	ENOG4105D1Q	UPF0246 protein
C3497_06495	ENOG4105C1J	atp-dependent rna helicase
C3497_06500	ENOG4105VEQ	Cold shock protein
C3497_06505	ENOG4108JA2	transcriptioN-repair coupling factor
C3497_06530	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
C3497_06535	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
C3497_06560	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
C3497_06565	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
C3497_06570	ENOG4105C9X	ppx gppa phosphatase
C3497_06580	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
C3497_06595	ENOG4105CEY	Amp-dependent synthetase and ligase
C3497_06605	ENOG4105EYA	deoxyribonuclease
C3497_06610	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
C3497_06620	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C3497_06630	ENOG4109015	Biopolymer transport protein exbD tolR
C3497_06635	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
C3497_06640	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
C3497_06645	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
C3497_06650	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
C3497_06655	ENOG4108V1U	phospholipid-binding protein
C3497_06660	ENOG4105CJR	Integral membrane protein (MviN
C3497_06665	ENOG4108IG5	Transcriptional regulator
C3497_06670	ENOG4105BZJ	Electron transfer flavoprotein
C3497_06675	ENOG4105C10	Electron transfer flavoprotein
C3497_06685	ENOG4105CSU	acyl-Coa dehydrogenase
C3497_06690	ENOG4105EKQ	RNA-directed DNA polymerase
C3497_06700	ENOG4107TF3	peptidylprolyl cis-trans isomerase
C3497_06710	ENOG4105K9H	YciI-like protein
C3497_06715	ENOG4107835	probably involved in intracellular septation (By similarity)
C3497_06725	ENOG4105E0F	Histidine kinase
C3497_06730	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C3497_06740	ENOG41072GX	Peptidase M22 Glycoprotease
C3497_06750	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
C3497_06765	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
C3497_06775	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
C3497_06780	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
C3497_06795	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
C3497_06805	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
C3497_06810	ENOG4105CHM	Aminotransferase
C3497_06815	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
C3497_06820	ENOG4105CZX	twitching motility protein
C3497_06825	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
C3497_06845	ENOG4105WVQ	Fe-S assembly protein IscX
C3497_06850	ENOG4108ZIT	Ferredoxin, 2FE-2S
C3497_06855	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
C3497_06860	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
C3497_06865	ENOG4108Z4V	iron-sulfur cluster assembly
C3497_06870	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
C3497_06875	ENOG4105C3J	Cysteine desulfurase
C3497_06880	ENOG4105C3J	Cysteine desulfurase
C3497_06885	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
C3497_06890	ENOG4105D7W	serine acetyltransferase
C3497_06900	ENOG4105ECY	inositol monophosphatase
C3497_06905	ENOG4107QIJ	Aconitate hydratase 2
C3497_06910	ENOG4107QM5	aconitate hydratase
C3497_06930	ENOG4105WQ3	Rna-binding protein
C3497_06940	ENOG4105PI0	Ferredoxin
C3497_06950	ENOG4106RHG	Yeca family
C3497_06955	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
C3497_06990	ENOG4107QMH	DNA methylase
C3497_06995	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
C3497_07000	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
C3497_07010	ENOG4105VDB	UPF0125 protein
C3497_07020	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
C3497_07025	ENOG4105CNG	UPF0061 protein
C3497_07030	ENOG4105DVT	helicase
C3497_07045	ENOG4105D6Z	AFG1 family ATPase
C3497_07050	ENOG4107QN2	dihydrolipoyl dehydrogenase
C3497_07055	ENOG4105C7S	Dehydrogenase
C3497_07060	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
C3497_07065	ENOG4105BZN	citrate synthase
C3497_07070	ENOG410681N	tpr repeat protein
C3497_07075	ENOG4105E33	succinate dehydrogenase
C3497_07095	ENOG4105FDP	GntR family transcriptional regulator
C3497_07100	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
C3497_07120	ENOG4105F2I	Transposase
C3497_07125	ENOG4105BZU	Histidine kinase
C3497_07130	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
C3497_07145	ENOG4105W87	Cbs domain
C3497_07150	ENOG4105D5U	fad dependent oxidoreductase
C3497_07155	ENOG4108JDX	DNA polymerase iii, epsilon subunit
C3497_07160	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C3497_07170	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
C3497_07185	ENOG4105E9H	Lytic Murein transglycosylase
C3497_07195	ENOG4108YZY	peptidylprolyl cis-trans isomerase
C3497_07200	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3497_07205	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
C3497_07225	ENOG4105C0H	protease
C3497_07230	ENOG4105DAN	ATP-dependent protease
C3497_07235	ENOG4105C0B	DNA polymerase III (alpha subunit)
C3497_07240	ENOG4105CRQ	synthase (Component I)
C3497_07245	ENOG4105BZU	Histidine kinase
C3497_07285	ENOG4105FQT	
C3497_07305	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C3497_07310	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C3497_07315	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C3497_07320	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
C3497_07325	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C3497_07335	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3497_07340	ENOG4105DZP	Membrane-associated zinc metalloprotease
C3497_07345	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
C3497_07350	ENOG4105KNE	Phosphatidate cytidylyltransferase
C3497_07355	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
C3497_07360	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
C3497_07365	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
C3497_07370	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
C3497_07375	ENOG4105CE9	30S ribosomal protein S2
C3497_07380	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
C3497_07385	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
C3497_07390	ENOG4108TEB	UPF0114 protein
C3497_07395	ENOG4105D9P	serine threonine protein kinase
C3497_07415	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C3497_07420	ENOG4105FE1	phytoene synthase
C3497_07425	ENOG4105FE1	phytoene synthase
C3497_07430	ENOG4107S11	squalene-associated FAD-dependent desaturase
C3497_07440	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
C3497_07455	ENOG4105CJ3	phosphate transporter
C3497_07465	ENOG4105D6S	protein involved in catabolism of external DNA
C3497_07470	ENOG4108Z0R	Transferase
C3497_07480	ENOG4105K4H	Nlp p60 protein
C3497_07485	ENOG4105C2X	Arabinose 5-phosphate isomerase
C3497_07490	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
C3497_07495	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C3497_07500	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
C3497_07505	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
C3497_07525	ENOG4105FE9	pseudouridine synthase
C3497_07530	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
C3497_07535	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
C3497_07540	ENOG4105C31	Tryptophanyl-tRNA synthetase
C3497_07545	ENOG4108Z4T	Peptidase M50
C3497_07550	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
C3497_07555	ENOG4105DB7	PHP domain protein
C3497_07580	ENOG4108WWZ	General secretion pathway protein J
C3497_07585	ENOG4105X5Z	General secretion pathway protein I
C3497_07590	ENOG4105PBE	general secretion pathway protein h
C3497_07595	ENOG4108VAU	general secretion pathway protein G
C3497_07600	ENOG4105D7Q	type ii secretion system
C3497_07605	ENOG4107QHF	type ii secretion system protein e
C3497_07610	ENOG4105GVR	general secretion pathway protein D
C3497_07620	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
C3497_07625	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
C3497_07630	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3497_07650	ENOG4107QZ7	Cellulose synthase catalytic subunit
C3497_07655	ENOG4105DUM	transcriptional regulator, lysR family
C3497_07660	ENOG4105DP0	ferredoxin-NADP reductase
C3497_07665	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_07670	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
C3497_07675	ENOG4105C5H	ABC transporter
C3497_07695	ENOG4107E2E	PKHD-type hydroxylase
C3497_07700	ENOG4108IU3	tonb-dependent siderophore receptor
C3497_07705	ENOG4105BZU	Histidine kinase
C3497_07710	ENOG4106PMH	Extracellular solute-binding protein family 3
C3497_07755	ENOG4105C26	Dehydrogenase
C3497_07760	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
C3497_07780	ENOG4105BZU	Histidine kinase
C3497_07800	ENOG4105DZG	Dehydrogenase
C3497_07815	ENOG4105BZU	Histidine kinase
C3497_07820	ENOG4105WH1	Two component transcriptional regulator luxr family
C3497_07830	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
C3497_07835	ENOG4105WF7	pyrroloquinoline quinone biosynthesis protein d
C3497_07840	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
C3497_07845	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
C3497_07895	ENOG4105CHB	tonB-dependent Receptor
C3497_07905	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C3497_07915	ENOG4108ZAF	Molybdopterin
C3497_07920	ENOG4105M00	molybdopterin converting factor, subunit 1
C3497_07925	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
C3497_07930	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
C3497_07935	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
C3497_07940	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
C3497_07950	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
C3497_07965	ENOG4107S2Z	UPF0761 membrane protein
C3497_07975	ENOG4105K5M	30s ribosomal protein S16
C3497_07980	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
C3497_07985	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
C3497_07990	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
C3497_08000	ENOG4108M8S	permease YjgP YjgQ family protein
C3497_08005	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
C3497_08020	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
C3497_08025	ENOG410846T	CoA-transferase family III
C3497_08030	ENOG4105N14	lysine exporter protein LysE YggA
C3497_08040	ENOG4105ETT	transcriptional Regulator, LysR family
C3497_08050	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
C3497_08055	ENOG4105ERG	peptidase m48, ste24p
C3497_08060	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C3497_08080	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C3497_08085	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C3497_08095	ENOG4105D78	K07001 NTE family protein
C3497_08120	ENOG4105C08	Histidine kinase
C3497_08125	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
C3497_08130	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
C3497_08140	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
C3497_08145	ENOG4108WKG	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
C3497_08150	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
C3497_08155	ENOG4105CQM	Urea amidohydrolase subunit alpha
C3497_08160	ENOG4105KI2	Urea amidohydrolase subunit beta
C3497_08165	ENOG4108YZ9	Urea amidohydrolase subunit gamma
C3497_08170	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
C3497_08180	ENOG4108IV0	ABC, transporter
C3497_08245	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
C3497_08250	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
C3497_08260	ENOG4107EP5	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
C3497_08280	ENOG4105BZS	acriflavin resistance protein
C3497_08285	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
C3497_08290	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
C3497_08295	ENOG4105C02	permease
C3497_08310	ENOG4105CA0	peroxidase
C3497_08315	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
C3497_08320	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C3497_08325	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
C3497_08330	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
C3497_08335	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
C3497_08340	ENOG4105DGN	Electron transport complex
C3497_08345	ENOG4108R3D	Electron transport complex
C3497_08350	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
C3497_08355	ENOG4105D6A	Electron transport complex
C3497_08365	ENOG4105DZB	Electron transport complex
C3497_08370	ENOG4105CSM	endonuclease III
C3497_08380	ENOG4108V0P	LemA family
C3497_08385	ENOG4105D0M	Protease HtpX homolog
C3497_08390	ENOG4106RE7	Cytochrome
C3497_08395	ENOG4106RE7	Cytochrome
C3497_08405	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C3497_08415	ENOG4105CPI	Metal Dependent Phosphohydrolase
C3497_08430	ENOG4105CMQ	Chloride channel
C3497_08435	ENOG4105VFB	Binds the 23S rRNA (By similarity)
C3497_08445	ENOG4107QP8	phosphohexose isomerase
C3497_08450	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
C3497_08455	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
C3497_08465	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
C3497_08480	ENOG4105CHU	acetyl-coa acetyltransferase
C3497_08485	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
C3497_08520	ENOG4105F2I	Transposase
C3497_08605	ENOG4105CFH	Aspartokinase
C3497_08630	ENOG4107S7U	Sulfide dehydrogenase
C3497_08640	ENOG4105KJB	cyd operon protein YbgE
C3497_08650	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
C3497_08655	ENOG4105C4M	(Ubiquinol oxidase) subunit I
C3497_08665	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C3497_08670	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C3497_08700	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
C3497_08710	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
C3497_08720	ENOG4108UM1	dedA family
C3497_08725	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
C3497_08740	ENOG4105CMI	transporter
C3497_08745	ENOG4105CJ1	ABC, transporter
C3497_08750	ENOG4105D0S	secretion protein (HlyD
C3497_08780	ENOG4105DJ4	phosphatidylserine decarboxylase
C3497_08800	ENOG4105BZU	Histidine kinase
C3497_08810	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
C3497_08820	ENOG4107QN1	sodium solute
C3497_08825	ENOG4108IRC	dna polymerase iii
C3497_08830	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C3497_08835	ENOG4105BZU	Histidine kinase
C3497_08845	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C3497_08860	ENOG4105DU1	integral membrane protein, terc
C3497_08870	ENOG4105IPI	Membrane
C3497_08890	ENOG4105C0A	alcohol dehydrogenase
C3497_08895	ENOG4108VKQ	nitriC oxide reductase
C3497_08900	ENOG4105DSQ	Nitric oxide reductase
C3497_08915	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
C3497_08930	ENOG4105FAE	von Willebrand factor, type A
C3497_08935	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
C3497_08950	ENOG4108UMR	transcriptional regulator AsnC family
C3497_08960	ENOG4108ZGY	Transcriptional regulator (AsnC family)
C3497_08965	ENOG4106P6N	cytochrome d1 heme region
C3497_08990	ENOG4105CUW	cytochrome C-TYPE protein
C3497_09000	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
C3497_09005	ENOG4105CBP	Major Facilitator
C3497_09010	ENOG4105EGI	Transcriptional regulator
C3497_09020	ENOG4105BZU	Histidine kinase
C3497_09025	ENOG4105BZU	Histidine kinase
C3497_09030	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
C3497_09035	ENOG4107STF	Involved in phosphonate degradation (By similarity)
C3497_09045	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
C3497_09050	ENOG4105C4Y	ABC transporter
C3497_09055	ENOG4108WYP	Transcriptional regulator
C3497_09065	ENOG4105W39	Membrane
C3497_09075	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
C3497_09090	ENOG4105EW9	transcriptional regulator AsnC family
C3497_09095	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
C3497_09100	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
C3497_09110	ENOG4105F2I	Transposase
C3497_09130	ENOG4105WH1	Two component transcriptional regulator luxr family
C3497_09135	ENOG4105BZU	Histidine kinase
C3497_09140	ENOG4105BZU	Histidine kinase
C3497_09145	ENOG4105I03	Flagellin
C3497_09150	ENOG4107RGC	Glycosyl transferase, family 2
C3497_09165	ENOG4105DTS	flagellar hook-associated
C3497_09170	ENOG4105MQ3	flagellar protein FliS
C3497_09185	ENOG4105VM1	flagellar
C3497_09190	ENOG4108T7K	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity)
C3497_09195	ENOG4105MYN	Zinc uptake regulation protein
C3497_09200	ENOG4108P3C	
C3497_09210	ENOG4105FDK	ABC transporter
C3497_09225	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
C3497_09235	ENOG4105BZU	Histidine kinase
C3497_09240	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
C3497_09245	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
C3497_09255	ENOG4108JIR	Flagellum-specific ATP synthase
C3497_09275	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
C3497_09280	ENOG4105DD5	Flagellar motor switch protein
C3497_09285	ENOG4105K0P	flagellar biosynthesis protein
C3497_09290	ENOG4105CN7	Flagellar biosynthetic protein FliP
C3497_09295	ENOG4105VS8	Flagellar biosynthetic protein fliq
C3497_09300	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
C3497_09310	ENOG4105DTJ	flagellar hook-associated protein
C3497_09310	ENOG4105DTJ	flagellar hook-associated protein
C3497_09315	ENOG4105E1Q	flagellar hook-associated protein
C3497_09320	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
C3497_09325	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
C3497_09330	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
C3497_09335	ENOG4105CGA	flagellar basal-body rod protein FlgG
C3497_09340	ENOG4108KPB	Flagellar basal-body rod protein FlgF
C3497_09345	ENOG4105BZE	flagellar hook protein, FlgE
C3497_09350	ENOG4105W00	Flagellar hook capping protein
C3497_09355	ENOG4108ZC9	flagellar basal-body rod protein flgc
C3497_09360	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
C3497_09365	ENOG4105CKS	Flagella basal body P-ring formation protein flgA
C3497_09380	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C3497_09385	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C3497_09395	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C3497_09400	ENOG4105EZE	Cupin 4 family protein
C3497_09410	ENOG4105GJM	(LipO)protein
C3497_09415	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
C3497_09425	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
C3497_09435	ENOG4105F8C	transglutaminase domain-containing protein
C3497_09440	ENOG4105CVE	Lytic murein transglycosylase
C3497_09445	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C3497_09450	ENOG4108K5P	(LipO)protein
C3497_09455	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
C3497_09460	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
C3497_09475	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C3497_09480	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
C3497_09485	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
C3497_09490	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
C3497_09495	ENOG4105VJV	50s ribosomal protein L35
C3497_09500	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
C3497_09505	ENOG4105C22	threonyL-tRNA synthetase
C3497_09535	ENOG4105C6T	cysteine synthase
C3497_09540	ENOG4105CFV	Tetratricopeptide repeat protein
C3497_09550	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C3497_09555	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
C3497_09560	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
C3497_09570	ENOG4105CIH	Imidazole acetol-phosphate transaminase
C3497_09585	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C3497_09590	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
C3497_09595	ENOG4105UYK	outer membrane protein a
C3497_09600	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
C3497_09630	ENOG4105MFV	ABC-2 type transporter
C3497_09635	ENOG4105EY8	ABC transporter
C3497_09640	ENOG4105E2K	Glycosyl transferase (Group 1
C3497_09645	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
C3497_09665	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C3497_09735	ENOG4105YAJ	CopG Arc MetJ
C3497_09750	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C3497_09840	ENOG4105WXW	Antirepressor
C3497_09910	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
C3497_09920	ENOG4105F0N	pyrophosphate phospho-hydrolase
C3497_09930	ENOG4105C59	p-type ATPase
C3497_09945	ENOG4105D4P	Coproporphyrinogen iii oxidase
C3497_09950	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
C3497_09960	ENOG4108YY7	Invasion gene expression up-regulator SirB
C3497_09975	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
C3497_10020	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
C3497_10030	ENOG4105C59	p-type ATPase
C3497_10045	ENOG4105D1F	ATP-binding protein
C3497_10055	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
C3497_10060	ENOG4105CHH	sulfate transporter
C3497_10065	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
C3497_10070	ENOG4105C0B	DNA polymerase III (alpha subunit)
C3497_10075	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
C3497_10080	ENOG4105C6K	Malic enzyme
C3497_10120	ENOG4107QHF	type ii secretion system protein e
C3497_10125	ENOG4105D7Q	type ii secretion system
C3497_10130	ENOG4108VAU	general secretion pathway protein G
C3497_10135	ENOG4105KHS	type IV fimbrial pilin protein
C3497_10145	ENOG4106855	Competence protein
C3497_10170	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
C3497_10175	ENOG4105C4R	Atp-dependent dna helicase
C3497_10185	ENOG4105C8T	Leucyl-tRNA synthetase
C3497_10195	ENOG4105DJF	DNA polymerase III, delta' subunit
C3497_10200	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
C3497_10210	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C3497_10215	ENOG4108Z66	YbaK ebsC protein
C3497_10220	ENOG4105VFQ	Histone family protein nucleoid-structuring protein H-NS
C3497_10225	ENOG4107ZVW	dihydroneopterin aldolase
C3497_10230	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
C3497_10235	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C3497_10260	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3497_10270	ENOG4108JU6	CBS domain protein
C3497_10275	ENOG4107QHF	type ii secretion system protein e
C3497_10300	ENOG4105C9M	aspartyl-trna synthetase
C3497_10330	ENOG4105CAS	nag kinase
C3497_10370	ENOG4105CEY	Amp-dependent synthetase and ligase
C3497_10400	ENOG4107RA4	Glycosyl transferase (Group 1
C3497_10430	ENOG4107T8Q	Glycosyl transferase (Group 1
C3497_10435	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
C3497_10440	ENOG4105CAQ	asparagine synthetase
C3497_10445	ENOG4105CPK	Glycosyl transferase (Group 1
C3497_10470	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
C3497_10485	ENOG4108QV3	biosynthesis protein
C3497_10510	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C3497_10530	ENOG4108IXY	short-chain dehydrogenase reductase
C3497_10550	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
C3497_10565	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
C3497_10570	ENOG4108XDN	Transcriptional regulator
C3497_10580	ENOG4107Z67	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C3497_10595	ENOG4105BZU	Histidine kinase
C3497_10600	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C3497_10605	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
C3497_10615	ENOG4105DK0	Indole-3-glycerol phosphate synthase
C3497_10620	ENOG4107QYG	anthranilate phosphoribosyltransferase
C3497_10625	ENOG4105DDQ	anthranilate synthase
C3497_10635	ENOG4106NZI	LysR family Transcriptional regulator
C3497_10710	ENOG4105C0H	protease
C3497_10715	ENOG4105D0M	Protease HtpX homolog
C3497_10730	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C3497_10740	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C3497_10745	ENOG4105VN1	Heat shock protein
C3497_10765	ENOG4107RJJ	Transcriptional regulator
C3497_10775	ENOG4105D5T	phosphonate abc transporter
C3497_10800	ENOG4105FT8	Phosphonate metabolism
C3497_10805	ENOG4105ENV	phosphonate C-P lyase system protein PhnK
C3497_10810	ENOG4105HRV	phosphonate c-p lyase system protein phnl
C3497_10815	ENOG4105FD8	phosphonate metabolism protein PhnM
C3497_10820	ENOG4105MFQ	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity)
C3497_10825	ENOG4107SA6	carbon-phosphorus lyase complex accessory protein
C3497_10845	ENOG4107VZS	Nicotinamide-nucleotide adenylyltransferase
C3497_10850	ENOG4105M03	Domain of unknown function (DUF955)
C3497_10885	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
C3497_10970	ENOG4108IJF	Heavy metal efflux pump, CzcA
C3497_10975	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
C3497_10995	ENOG4107R16	Multicopper oxidase
C3497_11020	ENOG4105GR3	Histidine kinase
C3497_11100	ENOG4105C0D	helicase
C3497_11110	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
C3497_11125	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
C3497_11195	ENOG4105W5Q	DNA repair protein (RadC
C3497_11280	ENOG4105DFP	Integrase
C3497_11290	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
C3497_11300	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C3497_11305	ENOG4105DJV	ribulose-phosphate 3-epimerase
C3497_11310	ENOG4107QHF	type ii secretion system protein e
C3497_11320	ENOG4105Q36	FHA domain containing protein
C3497_11325	ENOG4108ZF3	Phosphatase
C3497_11330	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
C3497_11335	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
C3497_11350	ENOG4107QNR	UPF0135 protein
C3497_11355	ENOG4105C0H	protease
C3497_11360	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
C3497_11365	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
C3497_11370	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
C3497_11375	ENOG4105K59	histidine triad (HIT) protein
C3497_11380	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
C3497_11385	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
C3497_11390	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
C3497_11395	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
C3497_11400	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
C3497_11405	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
C3497_11410	ENOG4105CIH	Imidazole acetol-phosphate transaminase
C3497_11415	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
C3497_11420	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
C3497_11425	ENOG4105NXH	GreA GreB family elongation factor
C3497_11435	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
C3497_11445	ENOG4105E3A	(ABC) transporter
C3497_11450	ENOG4105DA5	(ABC) transporter
C3497_11470	ENOG4107PE3	Mammalian cell entry related domain protein
C3497_11475	ENOG4105CY3	ABC transporter, permease
C3497_11480	ENOG4105DHJ	ABC, transporter
C3497_11485	ENOG4105C2X	Arabinose 5-phosphate isomerase
C3497_11490	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
C3497_11500	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
C3497_11505	ENOG4105E39	Enoyl-CoA hydratase
C3497_11515	ENOG4105E9Q	Acyl-transferase
C3497_11520	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
C3497_11525	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
C3497_11530	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
C3497_11535	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
C3497_11540	ENOG4108JU5	Magnesium and cobalt efflux protein
C3497_11545	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
C3497_11550	ENOG4105C9A	Phoh family
C3497_11555	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
C3497_11605	ENOG410600T	transposase
C3497_11615	ENOG41090A4	Pterin carbinolamine dehydratase
C3497_11620	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C3497_11625	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
C3497_11630	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
C3497_11635	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
C3497_11655	ENOG4108ZXC	Two component transcriptional regulator, luxr family
C3497_11660	ENOG4105BZU	Histidine kinase
C3497_11670	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
C3497_11675	ENOG4107QSN	dihydrolipoamide acetyltransferase
C3497_11680	ENOG4107QN2	dihydrolipoyl dehydrogenase
C3497_11700	ENOG4108IJF	Heavy metal efflux pump, CzcA
C3497_11750	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
C3497_11755	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
C3497_11765	ENOG4105D1H	recombination factor protein RarA
C3497_11770	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
C3497_11775	ENOG4105CNU	cell division protein FtsK
C3497_11780	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
C3497_11785	ENOG4105F2I	Transposase
C3497_11790	ENOG4105C3M	thioredoxin reductase
C3497_11795	ENOG4108DG9	Smr protein MutS2
C3497_11800	ENOG4108YZA	Nitrogen regulatory protein pii
C3497_11805	ENOG4105C4K	Nad synthetase
C3497_11810	ENOG4105CXN	decarboxylase
C3497_11815	ENOG4105DHP	deoxycytidine triphosphate deaminase
C3497_11820	ENOG4105EJC	lysr family transcriptional regulator
C3497_11825	ENOG4107QP3	malate synthase g
C3497_11835	ENOG4105C8V	SAICAR synthetase
C3497_11845	ENOG4105DGW	oligopeptidase A
C3497_11855	ENOG4107RU9	Transcriptional regulator, Crp Fnr family
C3497_11865	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
C3497_11870	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
C3497_11875	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
C3497_11880	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
C3497_11885	ENOG4105EHM	Aminoglycoside phosphotransferase
C3497_11890	ENOG4108S0S	Nucleotidyl transferase
C3497_11895	ENOG4107RAQ	aminopeptidase
C3497_11900	ENOG4105D0A	hydroxylase
C3497_11905	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
C3497_11920	ENOG4105C12	Phosphoribosylglycinamide synthetase
C3497_11925	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
C3497_11935	ENOG4105ECF	c-methyltransferase
C3497_11940	ENOG41076E6	Uroporphyrinogen-III Synthase
C3497_11945	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
C3497_11950	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
C3497_11990	ENOG4108NEV	two component transcriptional regulator, LytTR family
C3497_11995	ENOG4105CH7	arginosuccinase
C3497_12035	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
C3497_12040	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
C3497_12050	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
C3497_12075	ENOG4108ZF3	Phosphatase
C3497_12080	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
C3497_12085	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C3497_12100	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C3497_12105	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
C3497_12110	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
C3497_12115	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
C3497_12120	ENOG4105CPF	Cell wall formation (By similarity)
C3497_12125	ENOG4105DFU	Cell wall formation (By similarity)
C3497_12130	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
C3497_12135	ENOG4105CNI	cell division protein FtsW
C3497_12140	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
C3497_12145	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C3497_12150	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
C3497_12155	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
C3497_12160	ENOG4105CJN	penicillin-binding protein
C3497_12170	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
C3497_12175	ENOG4108V6E	Cell division protein mraZ
C3497_12190	ENOG4105EKE	dihydroorotase
C3497_12195	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
C3497_12200	ENOG41082RQ	UPF0102 protein
C3497_12205	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
C3497_12210	ENOG4105W4M	Transport-associated protein
C3497_12215	ENOG4105VCC	30S ribosomal protein S21
C3497_12230	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C3497_12240	ENOG4105DFU	Cell wall formation (By similarity)
C3497_12250	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3497_12255	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
C3497_12260	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
C3497_12265	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
C3497_12270	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
C3497_12280	ENOG41080IJ	Diacylglycerol kinase
C3497_12310	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
C3497_12320	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
C3497_12350	ENOG4108VAU	general secretion pathway protein G
C3497_12355	ENOG4105D7Q	type ii secretion system
C3497_12360	ENOG4107QHF	type ii secretion system protein e
C3497_12370	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C3497_12380	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
C3497_12385	ENOG4105DFG	type I secretion outer membrane protein
C3497_12390	ENOG41082J7	Rhodanese domain protein
C3497_12395	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
C3497_12410	ENOG4105XFK	Ferrous iron transport protein A
C3497_12415	ENOG4105CE1	Ferrous iron transport protein b
C3497_12425	ENOG4108UHE	carbonic anhydrase
C3497_12430	ENOG4105DWF	phosphomethylpyrimidine kinase
C3497_12435	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
C3497_12450	ENOG4105KRS	Proteinase inhibitor
C3497_12455	ENOG4105IPS	esterase
C3497_12460	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
C3497_12465	ENOG4105FR1	rard protein
C3497_12480	ENOG4105E2X	shikimate dehydrogenase
C3497_12485	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
C3497_12490	ENOG4105CJW	magnesium transporter
C3497_12590	ENOG4105CDU	Replicative dna helicase
C3497_12595	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
C3497_12600	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
C3497_12610	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
C3497_12615	ENOG4105CQ7	ATP-dependent helicase
C3497_12625	ENOG4105D64	Mechanosensitive ion channel
C3497_12630	ENOG4105CX6	glutaminyL-tRNA synthetase
C3497_12645	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
C3497_12650	ENOG4108E7F	Transporter
C3497_12655	ENOG4105FE9	pseudouridine synthase
C3497_12660	ENOG4105KJM	monovalent cation h antiporter subunit g
C3497_12665	ENOG4105W4C	monovalent cation H antiporter subunit F
C3497_12675	ENOG4107R4Z	monovalent cation h antiporter subunit d
C3497_12680	ENOG4108ZE9	Monovalent cation H antiporter subunit C
C3497_12685	ENOG4105D65	subunit l
C3497_12690	ENOG4108N16	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region
C3497_12695	ENOG41061WM	D-Alanyl-D-Alanine
C3497_12705	ENOG4105C6K	Malic enzyme
C3497_12710	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
C3497_12720	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
C3497_12725	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
C3497_12735	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
C3497_12740	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
C3497_12745	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
C3497_12750	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
C3497_12755	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
C3497_12760	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
C3497_12765	ENOG4108YZT	Adenosylcobinamide kinase
C3497_12770	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
C3497_12775	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
C3497_12780	ENOG4105CVJ	phosphoglycerate mutase
C3497_12785	ENOG4105BZ1	(ABC) transporter
C3497_12790	ENOG4107BJW	polysaccharide deacetylase
C3497_12795	ENOG4107TYR	Glycosyl Transferase
C3497_12800	ENOG4108I69	Glycosyl transferases group 1
C3497_12805	ENOG4105D16	lipopolysaccharide heptosyltransferase i
C3497_12815	ENOG4108I69	Glycosyl transferases group 1
C3497_12820	ENOG4105CPK	Glycosyl transferase (Group 1
C3497_12825	ENOG4105CG5	Glycosyl transferase (Group 1
C3497_12830	ENOG4107XU6	Glycosyl transferase (Group 1
C3497_12840	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
C3497_12845	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C3497_12850	ENOG4108Z9W	Outer membrane porin
C3497_12865	ENOG4105CAQ	asparagine synthetase
C3497_12885	ENOG4105CKK	Glycosyl transferase, family 2
C3497_12890	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
C3497_12900	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
C3497_12920	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C3497_12925	ENOG4107TUY	Histidine kinase
C3497_12935	ENOG4105CHM	Aminotransferase
C3497_12940	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
C3497_12945	ENOG4107W7X	Aldolase
C3497_12955	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
C3497_12960	ENOG4108MTB	glycosyl transferase family
C3497_12965	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
C3497_12980	ENOG4107QZ7	Cellulose synthase catalytic subunit
C3497_12990	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
C3497_12995	ENOG4105EJG	cellulose synthase
C3497_13005	ENOG4105CCT	upf0313 protein
C3497_13030	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C3497_13040	ENOG4105KWW	Biogenesis protein
C3497_13045	ENOG4107QX9	Thiol disulfide interChange protein
C3497_13050	ENOG4105DA4	cytochrome c-type biogenesis protein
C3497_13055	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
C3497_13065	ENOG41060IM	Heme exporter protein
C3497_13070	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
C3497_13075	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
C3497_13080	ENOG4105CUW	cytochrome C-TYPE protein
C3497_13085	ENOG4108ZMS	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity)
C3497_13090	ENOG4105GXZ	Ferredoxin-type protein NapH
C3497_13095	ENOG4108BGM	Quinol dehydrogenase periplasmic component
C3497_13100	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
C3497_13115	ENOG4105WH1	Two component transcriptional regulator luxr family
C3497_13120	ENOG4105BZU	Histidine kinase
C3497_13130	ENOG4108IRC	dna polymerase iii
C3497_13140	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
C3497_13145	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
C3497_13150	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
C3497_13155	ENOG4105DSJ	YicC domain protein
C3497_13165	ENOG4108ZF3	Phosphatase
C3497_13170	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
C3497_13175	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
C3497_13180	ENOG4105CSA	Coproporphyrinogen iii oxidase
C3497_13190	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
C3497_13195	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
C3497_13200	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
C3497_13210	ENOG4107SDU	Methyl-accepting chemotaxis
C3497_13225	ENOG4105BZU	Histidine kinase
C3497_13230	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C3497_13240	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
C3497_13255	ENOG4105EKQ	RNA-directed DNA polymerase
C3497_13265	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
C3497_13270	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
C3497_13275	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
C3497_13280	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
C3497_13285	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C3497_13290	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C3497_13295	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C3497_13300	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
C3497_13310	ENOG4105FA0	parb-like partition protein
C3497_13315	ENOG4107QJE	Chromosome Partitioning Protein
C3497_13320	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
C3497_13325	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
C3497_13330	ENOG4105DXC	membrane
C3497_13340	ENOG4105EW9	transcriptional regulator AsnC family
C3497_13350	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
C3497_13380	ENOG4107RH8	nuclease SbcCD subunit D
C3497_13385	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
C3497_13395	ENOG4105E0K	tonB-dependent siderophore receptor
C3497_13425	ENOG4105D05	Receptor
C3497_13430	ENOG4108S2J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
C3497_13450	ENOG4105CTK	cobaltochelatase, cobn subunit
C3497_13455	ENOG4105D05	Receptor
C3497_13475	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
C3497_13495	ENOG4105D05	Receptor
C3497_13500	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
C3497_13505	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
C3497_13510	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
C3497_13515	ENOG4105I3K	Ferric uptake regulator, Fur family
C3497_13530	ENOG4105YHG	TonB family
C3497_13535	ENOG4108UQY	Iron-storage protein
C3497_13560	ENOG4105C5X	domain protein
C3497_13565	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
C3497_13570	ENOG4105E0C	molybdate abc transporter
C3497_13575	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
C3497_13580	ENOG4107QYX	exodeoxyribonuclease v alpha
C3497_13585	ENOG4107QKA	exodeoxyribonuclease V beta
C3497_13590	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_13595	ENOG4105BZU	Histidine kinase
C3497_13600	ENOG4105BZU	Histidine kinase
C3497_13620	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
C3497_13625	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
C3497_13630	ENOG4108ZAI	phosphatidylglycerophosphatase a
C3497_13635	ENOG4107TH8	cina domain protein
C3497_13640	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
C3497_13645	ENOG4108004	Modulates RecA activity (By similarity)
C3497_13650	ENOG4108IUZ	ABC transporter
C3497_13655	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C3497_13660	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
C3497_13665	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
C3497_13670	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
C3497_13680	ENOG4105F2I	Transposase
C3497_13685	ENOG4105BZU	Histidine kinase
C3497_13690	ENOG4105C7B	Threonine dehydratase
C3497_13695	ENOG4105BZU	Histidine kinase
C3497_13700	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
C3497_13715	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
C3497_13735	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
C3497_13740	ENOG4105BZS	acriflavin resistance protein
C3497_13745	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
C3497_13750	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
C3497_13770	ENOG4105BZU	Histidine kinase
C3497_13780	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
C3497_13785	ENOG4108WUH	Transcriptional regulator, TetR family
C3497_13790	ENOG410600T	transposase
C3497_13795	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
C3497_13800	ENOG4107QRP	cobalamin biosynthesis protein CobW
C3497_13805	ENOG4105CTK	cobaltochelatase, cobn subunit
C3497_13830	ENOG41081F0	Precorrin-8x methylmutase
C3497_13845	ENOG4105QUC	reductase
C3497_13860	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
C3497_13900	ENOG4108RXX	maleylacetoacetate isomerase
C3497_13910	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
C3497_13915	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
C3497_13920	ENOG4105C2W	permease
C3497_13930	ENOG4105CGK	Exodeoxyribonuclease III
C3497_13935	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
C3497_13945	ENOG4108J2R	molybdopterin oxidoreductase
C3497_13950	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
C3497_13960	ENOG4105M4H	endoribonuclease L-psp
C3497_13970	ENOG4105D4A	Cell wall formation (By similarity)
C3497_13990	ENOG4105C0Z	ABC transporter
C3497_13995	ENOG4108IV0	ABC, transporter
C3497_14000	ENOG4105C32	Amino acid ABC transporter (Permease)
C3497_14005	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
C3497_14020	ENOG4105EZ7	amino acid ABC transporter
C3497_14025	ENOG4105DRP	amino acid AbC transporter
C3497_14030	ENOG4105CDA	abc transporter atp-binding protein
C3497_14040	ENOG4105EHZ	conserved protein UCP016719
C3497_14045	ENOG4105CHH	sulfate transporter
C3497_14050	ENOG41080RH	Thioredoxin
C3497_14055	ENOG4106NZI	LysR family Transcriptional regulator
C3497_14060	ENOG4105D94	Major Facilitator Superfamily
C3497_14080	ENOG41060M0	Crispr-associated protein, cse4 family
C3497_14085	ENOG4108VWQ	crispr-associated protein
C3497_14100	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
C3497_14105	ENOG4105PWE	CRISPR-associated protein cas2
C3497_14135	ENOG4105C3R	Methionine synthase
C3497_14145	ENOG4105C0Z	ABC transporter
C3497_14150	ENOG4108IV0	ABC, transporter
C3497_14155	ENOG4105C2C	drug resistance transporter, Bcr CflA
C3497_14160	ENOG4105C0P	Mg chelatase subunit ChlI
C3497_14165	ENOG4105W0Z	cytoplasmic protein
C3497_14175	ENOG4108YZA	Nitrogen regulatory protein pii
C3497_14180	ENOG4105BZU	Histidine kinase
C3497_14190	ENOG4105ECA	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein
C3497_14195	ENOG4105C5H	ABC transporter
C3497_14215	ENOG4105ETT	transcriptional Regulator, LysR family
C3497_14220	ENOG4107RT3	EamA-like transporter family
C3497_14225	ENOG41081YB	ApbE family
C3497_14230	ENOG4105D7Z	glutathione synthase
C3497_14240	ENOG4105XEZ	This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the
C3497_14250	ENOG4105CFP	Peptidase U32
C3497_14255	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
C3497_14260	ENOG4105BZU	Histidine kinase
C3497_14270	ENOG4105C5H	ABC transporter
C3497_14285	ENOG4105CJ3	phosphate transporter
C3497_14290	ENOG4105YHU	PTS system
C3497_14295	ENOG41080Z8	PHOSPHOCARRIER protein
C3497_14300	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
C3497_14305	ENOG4105DWV	Homoserine O-trans-acetylase
C3497_14310	ENOG4105DWV	Homoserine O-trans-acetylase
C3497_14320	ENOG4105BZU	Histidine kinase
C3497_14330	ENOG41077A9	carbonic anhydrase
C3497_14335	ENOG4105DKQ	ROK family
C3497_14340	ENOG4105C25	Primosomal protein n'
C3497_14345	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
C3497_14350	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
C3497_14355	ENOG4105C1A	potassium transporter peripheral membrane
C3497_14360	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C3497_14365	ENOG4105ES5	Histidine kinase
C3497_14375	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C3497_14380	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
C3497_14385	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
C3497_14395	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
C3497_14400	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
C3497_14405	ENOG4105X5M	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
C3497_14415	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
C3497_14420	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
C3497_14425	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C3497_14445	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
C3497_14460	ENOG4105DH7	May be involved in recombination (By similarity)
C3497_14470	ENOG4105I08	Pseudouridine synthase
C3497_14480	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
C3497_14490	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C3497_14500	ENOG4105KA7	cytochrome C
C3497_14505	ENOG4105C8Q	Methyl-accepting chemotaxis
C3497_14510	ENOG4105C0H	protease
C3497_14515	ENOG4105GAV	receptor
C3497_14520	ENOG4105DSY	exodeoxyribonuclease V, gamma
C3497_14530	ENOG4105CKI	cobalamin synthesis protein
C3497_14535	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3497_14540	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
C3497_14545	ENOG4105CVE	Lytic murein transglycosylase
C3497_14550	ENOG4105CHR	reductase
C3497_14555	ENOG4105CYM	Glutathione S-transferase
C3497_14560	ENOG410832A	alpha/beta hydrolase fold
C3497_14580	ENOG4105CHR	reductase
C3497_14585	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
C3497_14595	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C3497_14600	ENOG4107SDU	Methyl-accepting chemotaxis
C3497_14615	ENOG4105C4R	Atp-dependent dna helicase
C3497_14630	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
C3497_14635	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
C3497_14640	ENOG4108Z43	UPF0250 protein
C3497_14645	ENOG4105F0I	Aminotransferase
C3497_14650	ENOG4105DZ1	carboxypeptidase
C3497_14660	ENOG4105CNI	cell division protein FtsW
C3497_14665	ENOG4105CJN	penicillin-binding protein
C3497_14675	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
C3497_14680	ENOG4105DFF	Rod shape-determining protein mreb
C3497_14685	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C3497_14690	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
C3497_14695	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C3497_14700	ENOG4105D03	DNA-3-methyladenine glycosylase II
C3497_14705	ENOG4108KS2	transglutaminase domain protein
C3497_14710	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3497_14715	ENOG4105D0M	Protease HtpX homolog
C3497_14720	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
C3497_14730	ENOG4108WZM	domain protein
C3497_14735	ENOG4105C79	DNA protecting protein DprA
C3497_14740	ENOG4108RPN	Protein smg homolog
C3497_14745	ENOG4105C9U	ATP-dependent DNA helicase RecQ
C3497_14755	ENOG4105C5Q	Transcriptional regulator