locus-tag	class	description
C3497_00010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C3497_00015	COG0602	queuosine metabolic process
C3497_00025	COG2885	chlorophyll binding
C3497_00030	COG0823	Involved in the tonB-independent uptake of proteins
C3497_00045	COG0811	peptide transport
C3497_00050	COG0824	Thioesterase
C3497_00060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C3497_00065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C3497_00080	COG1132	(ABC) transporter
C3497_00095	COG2895	sulfate adenylyltransferase (ATP) activity
C3497_00100	COG0175	sulfate reduction
C3497_00105	COG0175	sulfate reduction
C3497_00115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3497_00120	COG0583	DNA-binding transcription factor activity
C3497_00125	COG0252	asparaginase activity
C3497_00130	COG1027	Aspartate ammonia-lyase
C3497_00135	COG5265	(ABC) transporter
C3497_00155	COG1960	acyl-CoA dehydrogenase activity
C3497_00180	COG2067	long-chain fatty acid transport protein
C3497_00185	COG1024	Enoyl-CoA hydratase
C3497_00185	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3497_00190	COG0183	Belongs to the thiolase family
C3497_00205	COG1805	sodium ion transport
C3497_00220	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C3497_00230	COG1024	Enoyl-CoA hydratase
C3497_00255	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C3497_00265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3497_00270	COG3161	chorismate lyase activity
C3497_00275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C3497_00280	COG0284	orotidine-5'-phosphate decarboxylase activity
C3497_00295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C3497_00330	COG1965	Belongs to the frataxin family
C3497_00365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3497_00370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3497_00375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C3497_00380	COG0069	glutamate synthase activity
C3497_00380	COG0067	glutamate synthase
C3497_00380	COG0070	glutamate synthase
C3497_00390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3497_00400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3497_00450	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3497_00455	COG2070	2-Nitropropane dioxygenase
C3497_00460	COG2860	membrane
C3497_00475	COG5001	Diguanylate cyclase
C3497_00490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3497_00495	COG3132	Protein of unknown function, DUF480
C3497_00500	COG0129	dihydroxy-acid dehydratase activity
C3497_00520	COG1121	(ABC) transporter
C3497_00525	COG0735	belongs to the Fur family
C3497_00535	COG1136	(ABC) transporter
C3497_00550	COG1194	a g-specific adenine glycosylase
C3497_00555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3497_00570	COG0310	cobalt ion transport
C3497_00575	COG0310	cobalt ion transport
C3497_00585	COG1122	ATPase activity
C3497_00595	COG3852	Histidine kinase
C3497_00605	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C3497_00610	COG0840	transmembrane signaling receptor activity
C3497_00620	COG2204	response regulator
C3497_00625	COG1024	Enoyl-CoA hydratase
C3497_00625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3497_00630	COG0309	Hydrogenase expression formation protein (HypE)
C3497_00635	COG0409	Hydrogenase expression formation protein
C3497_00640	COG0298	carbon dioxide binding
C3497_00645	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C3497_00655	COG0375	protein maturation
C3497_00700	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C3497_00715	COG1902	pentaerythritol trinitrate reductase activity
C3497_00725	COG1304	FMN binding
C3497_00730	COG0583	DNA-binding transcription factor activity
C3497_00735	COG0583	DNA-binding transcription factor activity
C3497_00740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3497_00760	COG3706	GGDEF domain
C3497_00770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3497_00775	COG0459	protein refolding
C3497_00790	COG1024	Enoyl-CoA hydratase
C3497_00795	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3497_00800	COG2050	protein possibly involved in aromatic compounds catabolism
C3497_00810	COG3396	Phenylacetate-CoA oxygenase
C3497_00815	COG3460	Phenylacetate-CoA oxygenase
C3497_00820	COG3396	Phenylacetate-CoA oxygenase
C3497_00825	COG2151	metal-sulfur cluster biosynthetic enzyme
C3497_00830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3497_00840	COG0183	Belongs to the thiolase family
C3497_00855	COG0411	ABC transporter
C3497_00875	COG0513	Belongs to the DEAD box helicase family
C3497_00880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3497_00885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3497_00900	COG4232	protein-disulfide reductase activity
C3497_00910	COG0625	glutathione transferase activity
C3497_00950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3497_00960	COG0018	arginyl-trna synthetase
C3497_00970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3497_00990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3497_01005	COG0303	'Molybdopterin
C3497_01010	COG0437	4 iron, 4 sulfur cluster binding
C3497_01015	COG2414	aldehyde ferredoxin oxidoreductase
C3497_01040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3497_01055	COG3243	poly(R)-hydroxyalkanoic acid synthase
C3497_01075	COG1960	acyl-CoA dehydrogenase activity
C3497_01080	COG0183	Belongs to the thiolase family
C3497_01085	COG1960	acyl-CoA dehydrogenase activity
C3497_01095	COG2207	Transcriptional regulator
C3497_01100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3497_01135	COG1115	amino acid carrier protein
C3497_01140	COG1660	Displays ATPase and GTPase activities
C3497_01155	COG0642	Histidine kinase
C3497_01160	COG0745	RESPONSE REGULATOR receiver
C3497_01170	COG0745	RESPONSE REGULATOR receiver
C3497_01180	COG1858	cytochrome C peroxidase
C3497_01190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3497_01195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3497_01200	COG2201	protein-glutamate methylesterase activity
C3497_01205	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C3497_01215	COG0840	transmembrane signaling receptor activity
C3497_01220	COG0835	chemotaxis
C3497_01225	COG0840	transmembrane signaling receptor activity
C3497_01230	COG0643	Histidine kinase
C3497_01230	COG2198	Histidine kinase
C3497_01240	COG0840	transmembrane signaling receptor activity
C3497_01250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C3497_01255	COG0393	Putative heavy-metal-binding
C3497_01265	COG0217	transcriptional regulatory protein
C3497_01275	COG0433	COG0433 Predicted ATPase
C3497_01285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3497_01290	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C3497_01295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C3497_01305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3497_01315	COG1560	Kdo2-lipid A biosynthetic process
C3497_01325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3497_01335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C3497_01360	COG2255	four-way junction helicase activity
C3497_01370	COG0632	four-way junction helicase activity
C3497_01380	COG1530	ribonuclease E activity
C3497_01385	COG0424	maF-like protein
C3497_01390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3497_01395	COG0799	negative regulation of ribosome biogenesis
C3497_01400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3497_01415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3497_01440	COG1218	3'(2'),5'-bisphosphate nucleotidase
C3497_01445	COG0471	metal ion transport
C3497_01445	COG3273	potassium ion transport
C3497_01450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C3497_01465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3497_01470	COG0109	protoheme IX farnesyltransferase activity
C3497_01475	COG1612	heme a metabolic process
C3497_01505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C3497_01510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3497_01525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3497_01535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C3497_01540	COG1492	cobalamin metabolic process
C3497_01575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3497_01580	COG1960	acyl-CoA dehydrogenase activity
C3497_01590	COG0840	transmembrane signaling receptor activity
C3497_01620	COG1024	Enoyl-CoA hydratase
C3497_01625	COG1253	flavin adenine dinucleotide binding
C3497_01630	COG1802	Transcriptional regulator
C3497_01635	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3497_01635	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3497_01640	COG1703	isobutyryl-CoA mutase activity
C3497_01645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3497_01650	COG0439	Biotin carboxylase
C3497_01655	COG1509	lysine 2,3-aminomutase activity
C3497_01670	COG4191	Histidine kinase
C3497_01670	COG0784	Response regulator, receiver
C3497_01680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3497_01680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3497_01680	COG1703	isobutyryl-CoA mutase activity
C3497_01690	COG1022	Amp-dependent synthetase and ligase
C3497_01695	COG0411	ABC transporter
C3497_01700	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3497_01725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3497_01735	COG2205	protein histidine kinase activity
C3497_01755	COG0500	methyltransferase
C3497_01765	COG0277	FAD linked oxidase domain protein
C3497_01785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3497_01795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3497_01805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3497_01810	COG0081	regulation of translation
C3497_01815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3497_01820	COG0222	ribosome binding
C3497_01825	COG0085	RNA polymerase activity
C3497_01830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3497_01835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3497_01840	COG0049	tRNA binding
C3497_01845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3497_01850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3497_01855	COG0051	transcription antitermination factor activity, RNA binding
C3497_01860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3497_01865	COG0088	Forms part of the polypeptide exit tunnel
C3497_01870	COG0089	rRNA binding
C3497_01875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3497_01880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3497_01885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C3497_01890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3497_01895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3497_01900	COG0255	Belongs to the universal ribosomal protein uL29 family
C3497_01905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3497_01910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3497_01915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3497_01920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3497_01925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3497_01930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3497_01935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3497_01940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3497_01945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3497_01950	COG1841	ribosomal large subunit assembly
C3497_01955	COG0200	Binds to the 23S rRNA
C3497_01960	COG0201	protein transport
C3497_01965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3497_01970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3497_01975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3497_01980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3497_01985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3497_01990	COG0202	RNA polymerase activity
C3497_01995	COG0203	ribosomal protein L17
C3497_02000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3497_02020	COG2814	Major facilitator Superfamily
C3497_02025	COG0629	single-stranded DNA binding
C3497_02030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C3497_02035	COG0732	type I restriction modification DNA specificity domain
C3497_02045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3497_02050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3497_02060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3497_02090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C3497_02090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C3497_02095	COG4654	Cytochrome c, class I
C3497_02105	COG3852	Histidine kinase
C3497_02110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C3497_02115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3497_02115	COG0543	2 iron, 2 sulfur cluster binding
C3497_02130	COG0746	molybdenum cofactor guanylyltransferase activity
C3497_02160	COG0762	integral membrane protein
C3497_02165	COG1872	DUF167
C3497_02180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3497_02185	COG0540	Belongs to the ATCase OTCase family
C3497_02190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3497_02195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3497_02200	COG1678	Uncharacterized ACR, COG1678
C3497_02205	COG0415	Belongs to the DNA photolyase family
C3497_02210	COG2198	Histidine kinase
C3497_02210	COG0643	Histidine kinase
C3497_02215	COG0840	transmembrane signaling receptor activity
C3497_02220	COG0835	chemotaxis
C3497_02245	COG0352	thiamine-phosphate diphosphorylase activity
C3497_02250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3497_02255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3497_02260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3497_02265	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C3497_02275	COG0494	nUDIX hydrolase
C3497_02280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C3497_02285	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C3497_02290	COG0237	dephospho-CoA kinase activity
C3497_02300	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
C3497_02305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3497_02320	COG3852	Histidine kinase
C3497_02345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3497_02355	COG0662	Cupin 2, conserved barrel domain protein
C3497_02360	COG1850	ribulose-bisphosphate carboxylase activity
C3497_02365	COG3568	Endonuclease Exonuclease Phosphatase
C3497_02370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3497_02375	COG1832	CoA-binding protein
C3497_02380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3497_02400	COG0789	Transcriptional regulator
C3497_02415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3497_02420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3497_02460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3497_02475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3497_02480	COG1196	nuclear chromosome segregation
C3497_02490	COG0732	type I restriction modification DNA specificity domain
C3497_02520	COG0582	viral genome integration into host DNA
C3497_02525	COG0012	GTP binding
C3497_02530	COG0193	aminoacyl-tRNA hydrolase activity
C3497_02535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3497_02540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3497_02550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3497_02555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C3497_02565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3497_02570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3497_02575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3497_02580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3497_02585	COG0742	ribosomal rna small subunit methyltransferase
C3497_02590	COG0612	Peptidase, M16
C3497_02595	COG0612	Peptidase, M16
C3497_02605	COG2884	Cell division ATP-binding protein ftsE
C3497_02610	COG2177	Part of the ABC transporter FtsEX involved in
C3497_02625	COG1132	(ABC) transporter
C3497_02645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3497_02655	COG1862	Preprotein translocase
C3497_02665	COG1464	Belongs to the NlpA lipoprotein family
C3497_02670	COG2011	ABC-type metal ion transport system permease component
C3497_02680	COG0410	ABC transporter
C3497_02700	COG0683	leucine binding
C3497_02710	COG1522	sequence-specific DNA binding
C3497_02715	COG0343	queuine tRNA-ribosyltransferase activity
C3497_02720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3497_02730	COG0583	DNA-binding transcription factor activity
C3497_02740	COG0670	Belongs to the BI1 family
C3497_02745	COG0825	malonyl-CoA metabolic process
C3497_02750	COG0037	tRNA processing
C3497_02765	COG0105	UTP biosynthetic process
C3497_02770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3497_02785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3497_02790	COG0124	histidyl-tRNA synthetase
C3497_02800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3497_02805	COG1160	GTP binding
C3497_02810	COG1923	regulation of RNA biosynthetic process
C3497_02815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3497_02820	COG0330	HflC and HflK could
C3497_02825	COG0330	HflC and HflK could
C3497_02835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C3497_02840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3497_02860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3497_02865	COG3707	response regulator
C3497_02870	COG1116	anion transmembrane transporter activity
C3497_02870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3497_02875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3497_02880	COG1116	anion transmembrane transporter activity
C3497_02890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3497_02905	COG0583	DNA-binding transcription factor activity
C3497_02935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3497_02945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3497_02950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3497_02955	COG0723	plastoquinol--plastocyanin reductase activity
C3497_02960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3497_02965	COG2857	Cytochrome c1
C3497_02970	COG0625	glutathione transferase activity
C3497_02975	COG2969	positive regulation of protein catabolic process
C3497_02980	COG0438	transferase activity, transferring glycosyl groups
C3497_02985	COG2703	oxygen carrier activity
C3497_02995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3497_03000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C3497_03010	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C3497_03015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3497_03020	COG0459	protein refolding
C3497_03025	COG0745	RESPONSE REGULATOR receiver
C3497_03030	COG0642	Histidine kinase
C3497_03040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3497_03055	COG4555	ABC transporter
C3497_03070	COG0741	lytic transglycosylase activity
C3497_03075	COG0442	prolyl-tRNA aminoacylation
C3497_03080	COG0494	nUDIX hydrolase
C3497_03095	COG0733	neurotransmitter:sodium symporter activity
C3497_03100	COG1522	sequence-specific DNA binding
C3497_03105	COG1116	anion transmembrane transporter activity
C3497_03110	COG0390	transport system, permease component
C3497_03135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3497_03155	COG2096	Adenosyltransferase
C3497_03160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3497_03165	COG0745	RESPONSE REGULATOR receiver
C3497_03165	COG3706	GGDEF domain
C3497_03175	COG0429	hydrolase of the alpha beta-hydrolase fold
C3497_03195	COG0668	transmembrane transport
C3497_03210	COG0482	sulfurtransferase activity
C3497_03230	COG3025	triphosphatase activity
C3497_03235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C3497_03240	COG3164	Protein of unknown function
C3497_03245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3497_03250	COG0312	modulator of DNA gyrase
C3497_03275	COG0745	RESPONSE REGULATOR receiver
C3497_03290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3497_03295	COG0542	response to heat
C3497_03300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C3497_03305	COG1278	Cold shock
C3497_03310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3497_03315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3497_03320	COG2003	Belongs to the UPF0758 family
C3497_03325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3497_03330	COG0756	dUTP diphosphatase activity
C3497_03340	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3497_03360	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C3497_03365	COG0538	isocitrate dehydrogenase activity
C3497_03370	COG0589	response to stress
C3497_03380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3497_03395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3497_03410	COG2885	chlorophyll binding
C3497_03415	COG3706	GGDEF domain
C3497_03435	COG0469	pyruvate kinase activity
C3497_03450	COG0126	phosphoglycerate kinase activity
C3497_03455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3497_03460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3497_03465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3497_03480	COG0483	inositol monophosphate 1-phosphatase activity
C3497_03485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3497_03495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3497_03495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3497_03505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C3497_03515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C3497_03520	COG2833	Protein of unknown function (DUF455)
C3497_03525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3497_03530	COG1333	cytochrome c biogenesis protein
C3497_03535	COG2863	cytochrome
C3497_03540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C3497_03560	COG2226	methyltransferase
C3497_03565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3497_03575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3497_03580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3497_03590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C3497_03595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C3497_03600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3497_03605	COG0640	Transcriptional regulator
C3497_03610	COG4942	peptidase
C3497_03615	COG0793	Belongs to the peptidase S41A family
C3497_03625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C3497_03630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3497_03630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3497_03635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3497_03640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3497_03645	COG0406	alpha-ribazole phosphatase activity
C3497_03650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C3497_03660	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C3497_03665	COG0312	modulator of DNA gyrase
C3497_03670	COG3028	Belongs to the UPF0307 family
C3497_03675	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3497_03680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C3497_03685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3497_03690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C3497_03695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C3497_03710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3497_03740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3497_03745	COG1360	Flagellar Motor Protein
C3497_03755	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C3497_03760	COG1765	OsmC-like protein
C3497_03765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3497_03770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3497_03775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3497_03780	COG0316	Belongs to the HesB IscA family
C3497_03785	COG0739	heme binding
C3497_03790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3497_03825	COG2030	dehydratase
C3497_03830	COG1469	GTP cyclohydrolase I activity
C3497_03835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3497_03840	COG0142	geranyltranstransferase activity
C3497_03845	COG1722	exodeoxyribonuclease VII activity
C3497_03855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3497_03860	COG1047	Peptidyl-prolyl cis-trans
C3497_03865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3497_03870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3497_03875	COG0196	riboflavin kinase activity
C3497_03880	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3497_03885	COG0802	atpase or kinase
C3497_03890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3497_03905	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C3497_03905	COG0662	Cupin 2, conserved barrel domain protein
C3497_03915	COG0564	pseudouridine synthase activity
C3497_03930	COG3243	poly(R)-hydroxyalkanoic acid synthase
C3497_03935	COG1028	Short-chain dehydrogenase reductase Sdr
C3497_03945	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C3497_03950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3497_03955	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3497_03960	COG0277	FAD linked oxidase domain protein
C3497_03995	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3497_04000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C3497_04020	COG0318	PFAM AMP-dependent synthetase and ligase
C3497_04025	COG0028	Belongs to the TPP enzyme family
C3497_04030	COG0440	acetolactate synthase activity
C3497_04035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3497_04040	COG2814	Major facilitator Superfamily
C3497_04045	COG0501	Belongs to the peptidase M48B family
C3497_04050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3497_04055	COG0066	3-isopropylmalate dehydratase activity
C3497_04060	COG0473	3-isopropylmalate dehydrogenase activity
C3497_04080	COG0101	tRNA pseudouridine synthase activity
C3497_04085	COG0135	phosphoribosylanthranilate isomerase activity
C3497_04090	COG0133	tryptophan synthase activity
C3497_04095	COG0159	tryptophan synthase activity
C3497_04100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3497_04105	COG0285	dihydrofolate synthase activity
C3497_04130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3497_04135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3497_04140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3497_04155	COG0215	cysteine-tRNA ligase activity
C3497_04165	COG0484	heat shock protein binding
C3497_04170	COG0443	Heat shock 70 kDa protein
C3497_04175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3497_04190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3497_04195	COG1420	regulation of RNA biosynthetic process
C3497_04200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3497_04205	COG0497	DNA recombination
C3497_04210	COG0735	belongs to the Fur family
C3497_04215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3497_04220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3497_04225	COG0784	Response regulator, receiver
C3497_04225	COG2205	protein histidine kinase activity
C3497_04225	COG5002	protein histidine kinase activity
C3497_04230	COG0505	Belongs to the CarA family
C3497_04235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3497_04240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3497_04255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C3497_04260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3497_04270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3497_04285	COG0573	inorganic phosphate transmembrane transporter activity
C3497_04310	COG0701	Predicted permease
C3497_04325	COG0798	PFAM Bile acid sodium symporter
C3497_04345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3497_04350	COG0640	Transcriptional regulator
C3497_04370	COG5433	transposase activity
C3497_04375	COG0149	triose-phosphate isomerase activity
C3497_04390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3497_04395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3497_04400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3497_04405	COG0649	NAD binding
C3497_04415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3497_04420	COG1034	ATP synthesis coupled electron transport
C3497_04425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C3497_04430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C3497_04440	COG0713	ATP synthesis coupled electron transport
C3497_04455	COG1007	ATP synthesis coupled electron transport
C3497_04470	COG0537	adenosine 5'-monophosphoramidase activity
C3497_04480	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C3497_04485	COG3383	formate dehydrogenase (NAD+) activity
C3497_04490	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
C3497_04495	COG3259	Nickel-dependent hydrogenase
C3497_04510	COG1230	cation diffusion facilitator family transporter
C3497_04525	COG2267	carboxylic ester hydrolase activity
C3497_04545	COG0326	Molecular chaperone. Has ATPase activity
C3497_04555	COG5002	protein histidine kinase activity
C3497_04555	COG0784	Response regulator, receiver
C3497_04555	COG2198	Histidine kinase
C3497_04565	COG2703	oxygen carrier activity
C3497_04585	COG3706	GGDEF domain
C3497_04615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3497_04625	COG2204	response regulator
C3497_04640	COG0741	lytic transglycosylase activity
C3497_04670	COG1704	LemA family
C3497_04675	COG2271	Major facilitator Superfamily
C3497_04685	COG0604	alcohol dehydrogenase
C3497_04695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3497_04700	COG2111	Na H antiporter
C3497_04700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3497_04705	COG1006	Multisubunit Na H antiporter MnhC subunit
C3497_04720	COG2212	antiporter activity
C3497_04725	COG1320	monovalent cation:proton antiporter activity
C3497_04760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3497_04765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3497_04770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3497_04775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3497_04780	COG0659	secondary active sulfate transmembrane transporter activity
C3497_04785	COG3622	Belongs to the hyi family
C3497_04790	COG0277	FAD linked oxidase domain protein
C3497_04795	COG0277	FAD linked oxidase domain protein
C3497_04800	COG0247	lactate metabolic process
C3497_04805	COG0631	protein serine/threonine phosphatase activity
C3497_04810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3497_04815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C3497_04820	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C3497_04850	COG0513	Belongs to the DEAD box helicase family
C3497_04855	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C3497_04860	COG0667	Aldo Keto reductase
C3497_04875	COG0584	glycerophosphoryl diester phosphodiesterase
C3497_04880	COG0142	geranyltranstransferase activity
C3497_04890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3497_04895	COG1840	ABC-type Fe3 transport system, periplasmic component
C3497_04905	COG0791	NLP P60 protein
C3497_04910	COG3039	Transposase
C3497_04925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3497_04930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3497_04940	COG0436	Aminotransferase
C3497_04950	COG1490	D-aminoacyl-tRNA deacylase activity
C3497_04975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3497_04975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C3497_04985	COG2719	SpoVR family
C3497_05005	COG2766	serine protein kinase
C3497_05010	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3497_05015	COG0740	serine-type endopeptidase activity
C3497_05020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3497_05050	COG0494	nUDIX hydrolase
C3497_05055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3497_05070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3497_05070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C3497_05075	COG2354	Protein conserved in bacteria
C3497_05080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3497_05090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3497_05105	COG1196	nuclear chromosome segregation
C3497_05125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3497_05140	COG1136	(ABC) transporter
C3497_05165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3497_05175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3497_05185	COG0739	heme binding
C3497_05200	COG0047	phosphoribosylformylglycinamidine synthase activity
C3497_05200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3497_05215	COG1999	signal sequence binding
C3497_05235	COG0824	Thioesterase
C3497_05240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3497_05250	COG0779	Required for maturation of 30S ribosomal subunits
C3497_05255	COG0195	Participates in both transcription termination and antitermination
C3497_05255	COG2251	uridine kinase activity
C3497_05260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3497_05265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3497_05270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3497_05275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3497_05280	COG1185	polyribonucleotide nucleotidyltransferase activity
C3497_05285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3497_05310	COG1115	amino acid carrier protein
C3497_05320	COG0252	asparaginase activity
C3497_05325	COG3245	cytochrome
C3497_05350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C3497_05375	COG4263	nitrous-oxide reductase activity
C3497_05385	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C3497_05405	COG0556	nucleotide-excision repair
C3497_05410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3497_05415	COG1530	ribonuclease E activity
C3497_05430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3497_05435	COG0424	maF-like protein
C3497_05440	COG1399	metal-binding, possibly nucleic acid-binding protein
C3497_05445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3497_05450	COG0416	fatty acid biosynthetic process
C3497_05455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3497_05470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3497_05475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3497_05485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3497_05510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3497_05520	COG0481	GTPase activity
C3497_05525	COG0681	Belongs to the peptidase S26 family
C3497_05535	COG0571	ribonuclease III activity
C3497_05540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3497_05545	COG1381	Involved in DNA repair and RecF pathway recombination
C3497_05550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C3497_05555	COG0736	holo-[acyl-carrier-protein] synthase activity
C3497_05560	COG1472	Belongs to the glycosyl hydrolase 3 family
C3497_05565	COG0322	excinuclease ABC activity
C3497_05570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3497_05620	COG3437	response regulator, receiver
C3497_05630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3497_05640	COG3039	Transposase
C3497_05675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3497_05680	COG1183	phosphatidylcholine synthase activity
C3497_05685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3497_05695	COG0028	Belongs to the TPP enzyme family
C3497_05710	COG0308	aminopeptidase N
C3497_05720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3497_05725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3497_05730	COG1428	Deoxynucleoside kinase
C3497_05745	COG0617	tRNA 3'-terminal CCA addition
C3497_05750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C3497_05760	COG0850	regulation of cytokinetic process
C3497_05770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C3497_05775	COG1393	Belongs to the ArsC family
C3497_05785	COG0676	glucose-6-phosphate 1-epimerase activity
C3497_05790	COG1042	CoA-binding domain protein
C3497_05790	COG0045	succinate-CoA ligase (ADP-forming) activity
C3497_05790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3497_05795	COG4251	negative regulation of phosphorylation
C3497_05800	COG0840	transmembrane signaling receptor activity
C3497_05815	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C3497_05830	COG4181	ATPase activity
C3497_05845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3497_05870	COG0402	S-adenosylhomocysteine deaminase activity
C3497_05905	COG0745	RESPONSE REGULATOR receiver
C3497_05905	COG3706	GGDEF domain
C3497_05925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3497_05930	COG1360	Flagellar Motor Protein
C3497_05940	COG2198	Histidine kinase
C3497_05940	COG0643	Histidine kinase
C3497_05945	COG0840	transmembrane signaling receptor activity
C3497_05955	COG2201	protein-glutamate methylesterase activity
C3497_05960	COG0784	Response regulator, receiver
C3497_05960	COG0835	chemotaxis
C3497_05965	COG0835	chemotaxis
C3497_05965	COG0784	Response regulator, receiver
C3497_05970	COG0745	RESPONSE REGULATOR receiver
C3497_05975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C3497_05980	COG0643	Histidine kinase
C3497_05980	COG2198	Histidine kinase
C3497_05990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3497_05995	COG0268	Binds directly to 16S ribosomal RNA
C3497_06005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3497_06010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3497_06015	COG0137	argininosuccinate synthase activity
C3497_06025	COG3123	guanosine phosphorylase activity
C3497_06030	COG1666	GTP binding
C3497_06035	COG0501	Belongs to the peptidase M48B family
C3497_06040	COG0071	Belongs to the small heat shock protein (HSP20) family
C3497_06055	COG4191	Histidine kinase
C3497_06060	COG0590	tRNA wobble adenosine to inosine editing
C3497_06065	COG1376	ErfK ybiS ycfS ynhG family protein
C3497_06085	COG0354	folic acid binding
C3497_06090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3497_06095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3497_06110	COG0084	hydrolase, TatD family'
C3497_06125	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3497_06175	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
C3497_06230	COG4659	FMN binding
C3497_06235	COG4658	electron transport chain
C3497_06250	COG4657	Part of a membrane complex involved in electron transport
C3497_06270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3497_06290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C3497_06310	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C3497_06330	COG0659	secondary active sulfate transmembrane transporter activity
C3497_06355	COG1305	Transglutaminase-like
C3497_06370	COG1473	amidohydrolase
C3497_06375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C3497_06380	COG2200	EAL domain
C3497_06390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3497_06400	COG0560	Phosphoserine phosphatase
C3497_06405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C3497_06410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C3497_06420	COG4372	Transposase
C3497_06435	COG2900	Belongs to the SlyX family
C3497_06440	COG0826	peptidase U32
C3497_06445	COG2703	oxygen carrier activity
C3497_06450	COG0471	metal ion transport
C3497_06450	COG3273	potassium ion transport
C3497_06455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C3497_06460	COG2226	methyltransferase
C3497_06465	COG2267	carboxylic ester hydrolase activity
C3497_06470	COG0156	8-amino-7-oxononanoate synthase activity
C3497_06480	COG3022	response to hydroperoxide
C3497_06485	COG2866	Carboxypeptidase
C3497_06495	COG0513	Belongs to the DEAD box helicase family
C3497_06500	COG1278	Cold shock
C3497_06505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3497_06530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3497_06535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3497_06550	COG3228	Belongs to the MtfA family
C3497_06560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3497_06565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C3497_06570	COG0248	Ppx GppA phosphatase
C3497_06575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3497_06580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3497_06595	COG0318	PFAM AMP-dependent synthetase and ligase
C3497_06605	COG0084	hydrolase, TatD family'
C3497_06610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3497_06620	COG1570	exodeoxyribonuclease VII activity
C3497_06625	COG0811	peptide transport
C3497_06630	COG0848	biopolymer transport protein
C3497_06635	COG1663	tetraacyldisaccharide 4'-kinase activity
C3497_06640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C3497_06645	COG0563	adenylate kinase activity
C3497_06650	COG0205	6-phosphofructokinase activity
C3497_06655	COG1881	PFAM PEBP family protein
C3497_06660	COG0728	peptidoglycan biosynthetic process
C3497_06665	COG1309	transcriptional regulator
C3497_06685	COG1960	acyl-CoA dehydrogenase activity
C3497_06700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3497_06710	COG2350	Protein conserved in bacteria
C3497_06715	COG2917	probably involved in intracellular septation
C3497_06730	COG0745	RESPONSE REGULATOR receiver
C3497_06750	COG1573	uracil-dna glycosylase
C3497_06760	COG0583	DNA-binding transcription factor activity
C3497_06775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3497_06795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3497_06805	COG1196	nuclear chromosome segregation
C3497_06810	COG0436	Aminotransferase
C3497_06815	COG2171	N-acyltransferase activity
C3497_06825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3497_06835	COG0784	Response regulator, receiver
C3497_06840	COG0386	Belongs to the glutathione peroxidase family
C3497_06850	COG0633	Ferredoxin
C3497_06855	COG0443	Heat shock 70 kDa protein
C3497_06860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C3497_06870	COG0822	iron-sulfur transferase activity
C3497_06875	COG1104	cysteine desulfurase activity
C3497_06880	COG1104	cysteine desulfurase activity
C3497_06890	COG1045	serine acetyltransferase
C3497_06910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3497_06930	COG2501	S4 domain
C3497_06950	COG3012	SEC-C Motif Domain Protein
C3497_06950	COG3318	Belongs to the UPF0149 family
C3497_06995	COG0519	Catalyzes the synthesis of GMP from XMP
C3497_06995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3497_07010	COG2914	Belongs to the UPF0125 (RnfH) family
C3497_07020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3497_07025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C3497_07030	COG1199	ATP-dependent helicase activity
C3497_07045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C3497_07050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3497_07055	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3497_07060	COG0567	Dehydrogenase, E1 component
C3497_07065	COG0372	Belongs to the citrate synthase family
C3497_07070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C3497_07075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3497_07080	COG1053	succinate dehydrogenase
C3497_07095	COG2188	Transcriptional regulator
C3497_07100	COG0039	L-malate dehydrogenase activity
C3497_07120	COG3039	Transposase
C3497_07130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3497_07145	COG0517	IMP dehydrogenase activity
C3497_07150	COG0579	oxidoreductase
C3497_07155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3497_07160	COG0328	RNA-DNA hybrid ribonuclease activity
C3497_07170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3497_07180	COG5001	Diguanylate cyclase
C3497_07180	COG4251	negative regulation of phosphorylation
C3497_07180	COG3706	GGDEF domain
C3497_07180	COG2203	Gaf domain
C3497_07185	COG0741	lytic transglycosylase activity
C3497_07185	COG1388	LysM domain
C3497_07200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3497_07205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3497_07225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3497_07230	COG1067	ATP-dependent peptidase activity
C3497_07235	COG0587	DNA-directed DNA polymerase activity
C3497_07245	COG5001	Diguanylate cyclase
C3497_07245	COG5002	protein histidine kinase activity
C3497_07295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3497_07305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3497_07310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3497_07315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3497_07320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3497_07325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C3497_07345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3497_07350	COG0575	Belongs to the CDS family
C3497_07355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3497_07360	COG0233	cytoplasmic translational termination
C3497_07365	COG0528	UMP kinase activity
C3497_07370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3497_07375	COG0052	Belongs to the universal ribosomal protein uS2 family
C3497_07380	COG0024	Methionine aminopeptidase
C3497_07385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C3497_07390	COG2862	Uncharacterized protein family, UPF0114
C3497_07395	COG2815	serine threonine protein kinase
C3497_07395	COG0515	serine threonine protein kinase
C3497_07415	COG1136	(ABC) transporter
C3497_07420	COG1562	ergosterol biosynthetic process
C3497_07430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C3497_07440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3497_07455	COG0306	phosphate transporter
C3497_07465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C3497_07480	COG0791	NLP P60 protein
C3497_07490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C3497_07495	COG0148	phosphopyruvate hydratase activity
C3497_07500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C3497_07505	COG0504	CTP synthase activity
C3497_07525	COG1187	pseudouridine synthase activity
C3497_07530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3497_07535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C3497_07540	COG0180	Tryptophanyl-tRNA synthetase
C3497_07545	COG1994	Peptidase M50
C3497_07550	COG0009	L-threonylcarbamoyladenylate synthase
C3497_07555	COG0613	PHP domain protein
C3497_07620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3497_07625	COG0509	glycine decarboxylation via glycine cleavage system
C3497_07630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3497_07630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3497_07650	COG1215	transferase activity, transferring glycosyl groups
C3497_07655	COG0583	DNA-binding transcription factor activity
C3497_07670	COG0840	transmembrane signaling receptor activity
C3497_07675	COG0488	(ABC) transporter
C3497_07695	COG3128	pkhd-type hydroxylase
C3497_07700	COG4774	siderophore transport
C3497_07710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3497_07730	COG2133	pyrroloquinoline quinone binding
C3497_07755	COG1012	belongs to the aldehyde dehydrogenase family
C3497_07760	COG3284	Transcriptional regulator
C3497_07820	COG2197	response regulator
C3497_07830	COG0535	radical SAM domain protein
C3497_07840	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C3497_07845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3497_07895	COG4772	TonB-dependent receptor
C3497_07905	COG0542	response to heat
C3497_07915	COG0314	molybdopterin synthase activity
C3497_07920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C3497_07925	COG0303	'Molybdopterin
C3497_07930	COG1763	Mo-molybdopterin cofactor biosynthetic process
C3497_07935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3497_07940	COG0601	transmembrane transport
C3497_07965	COG1295	ribonuclease BN
C3497_07975	COG0228	four-way junction DNA binding
C3497_07980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3497_07985	COG0336	Belongs to the RNA methyltransferase TrmD family
C3497_07990	COG0335	large ribosomal subunit rRNA binding
C3497_08000	COG0795	lipopolysaccharide-transporting ATPase activity
C3497_08005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3497_08020	COG0525	valine-tRNA ligase activity
C3497_08025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C3497_08030	COG1280	lysine exporter protein (LysE YggA)
C3497_08040	COG0583	DNA-binding transcription factor activity
C3497_08050	COG0425	Belongs to the sulfur carrier protein TusA family
C3497_08055	COG4783	chaperone-mediated protein folding
C3497_08060	COG0315	cyclic pyranopterin monophosphate synthase activity
C3497_08080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3497_08085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3497_08085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3497_08090	COG1607	acyl-coa hydrolase
C3497_08095	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3497_08120	COG2205	protein histidine kinase activity
C3497_08125	COG0745	RESPONSE REGULATOR receiver
C3497_08140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C3497_08145	COG0830	nickel cation binding
C3497_08150	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C3497_08155	COG0804	urea catabolic process
C3497_08160	COG0832	Belongs to the urease beta subunit family
C3497_08165	COG0831	urea catabolic process
C3497_08170	COG0829	nickel cation binding
C3497_08245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C3497_08250	COG1518	maintenance of DNA repeat elements
C3497_08260	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C3497_08280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3497_08290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3497_08295	COG0628	permease
C3497_08310	COG1858	cytochrome C peroxidase
C3497_08315	COG1178	ABC-type Fe3 transport system permease component
C3497_08320	COG3842	ATPase activity
C3497_08325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C3497_08330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C3497_08335	COG0167	dihydroorotate dehydrogenase activity
C3497_08340	COG4657	Part of a membrane complex involved in electron transport
C3497_08345	COG2878	Part of a membrane complex involved in electron transport
C3497_08350	COG4656	Part of a membrane complex involved in electron transport
C3497_08370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3497_08380	COG1704	LemA family
C3497_08385	COG0501	Belongs to the peptidase M48B family
C3497_08400	COG2119	membrane
C3497_08405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3497_08420	COG0426	domain, Protein
C3497_08420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3497_08435	COG0254	rRNA binding
C3497_08445	COG0166	Belongs to the GPI family
C3497_08450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C3497_08455	COG0501	Belongs to the peptidase M48B family
C3497_08465	COG1162	GTPase activity
C3497_08475	COG2308	Evidence 4 Homologs of previously reported genes of
C3497_08480	COG0183	Belongs to the thiolase family
C3497_08520	COG3039	Transposase
C3497_08605	COG0527	aspartate kinase activity
C3497_08620	COG0720	synthase
C3497_08630	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3497_08640	COG3790	cyd operon protein YbgE
C3497_08650	COG1294	oxidase, subunit
C3497_08665	COG2204	response regulator
C3497_08670	COG0723	plastoquinol--plastocyanin reductase activity
C3497_08690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3497_08690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3497_08700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3497_08710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3497_08720	COG1238	metal cluster binding
C3497_08725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3497_08740	COG0842	Transport permease protein
C3497_08745	COG0842	Transport permease protein
C3497_08745	COG1129	ABC transporter
C3497_08750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3497_08780	COG0688	phosphatidylethanolamine metabolic process
C3497_08800	COG3706	GGDEF domain
C3497_08810	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C3497_08820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3497_08825	COG2176	DNA-directed DNA polymerase activity
C3497_08825	COG5002	protein histidine kinase activity
C3497_08830	COG0745	RESPONSE REGULATOR receiver
C3497_08835	COG5002	protein histidine kinase activity
C3497_08845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3497_08860	COG0861	Integral membrane protein TerC family
C3497_08865	COG1253	flavin adenine dinucleotide binding
C3497_08870	COG0628	permease
C3497_08890	COG1454	alcohol dehydrogenase
C3497_08895	COG2010	Cytochrome c
C3497_08970	COG2010	Cytochrome c
C3497_08995	COG2010	Cytochrome c
C3497_09000	COG1648	precorrin-2 dehydrogenase activity
C3497_09000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3497_09005	COG0477	Major facilitator Superfamily
C3497_09010	COG0583	DNA-binding transcription factor activity
C3497_09020	COG0784	Response regulator, receiver
C3497_09020	COG2205	protein histidine kinase activity
C3497_09020	COG5002	protein histidine kinase activity
C3497_09025	COG2205	protein histidine kinase activity
C3497_09025	COG3850	Histidine kinase
C3497_09025	COG4999	Histidine kinase
C3497_09025	COG3437	response regulator, receiver
C3497_09030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3497_09045	COG3842	ATPase activity
C3497_09050	COG1840	ABC-type Fe3 transport system, periplasmic component
C3497_09055	COG1802	Transcriptional regulator
C3497_09065	COG1238	metal cluster binding
C3497_09075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3497_09095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3497_09110	COG3039	Transposase
C3497_09130	COG2197	response regulator
C3497_09135	COG3706	GGDEF domain
C3497_09140	COG3706	GGDEF domain
C3497_09165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C3497_09185	COG2257	FlhB HrpN YscU SpaS Family
C3497_09190	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C3497_09195	COG0735	belongs to the Fur family
C3497_09200	COG3746	phosphate-selective porin O and P
C3497_09210	COG1121	(ABC) transporter
C3497_09225	COG1677	Flagellar hook-basal body complex protein FliE
C3497_09235	COG3852	Histidine kinase
C3497_09240	COG1766	The M ring may be actively involved in energy transduction
C3497_09245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3497_09255	COG1157	protein secretion by the type III secretion system
C3497_09275	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3497_09285	COG3190	flagellar
C3497_09295	COG1987	bacterial-type flagellum assembly
C3497_09315	COG1256	bacterial-type flagellum assembly
C3497_09320	COG3951	Flagellar rod assembly protein muramidase FlgJ
C3497_09320	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3497_09325	COG1706	bacterial-type flagellum-dependent cell motility
C3497_09330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C3497_09335	COG4786	Flagellar basal body rod
C3497_09340	COG4787	bacterial-type flagellum-dependent cell motility
C3497_09345	COG1749	Flagellar hook protein flgE
C3497_09350	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C3497_09355	COG1558	bacterial-type flagellum-dependent cell motility
C3497_09360	COG1815	bacterial-type flagellum-dependent cell motility
C3497_09395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3497_09400	COG2850	peptidyl-arginine hydroxylation
C3497_09410	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C3497_09415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3497_09420	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3497_09425	COG0714	Associated with various cellular activities
C3497_09440	COG2951	lytic endotransglycosylase activity
C3497_09455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3497_09460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C3497_09475	COG0776	regulation of translation
C3497_09480	COG0072	phenylalanine-tRNA ligase activity
C3497_09480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3497_09485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3497_09490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3497_09495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3497_09500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3497_09505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3497_09540	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C3497_09550	COG0776	regulation of translation
C3497_09560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3497_09565	COG0287	Prephenate dehydrogenase
C3497_09590	COG0402	S-adenosylhomocysteine deaminase activity
C3497_09595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C3497_09595	COG2885	chlorophyll binding
C3497_09600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C3497_09640	COG0438	transferase activity, transferring glycosyl groups
C3497_09645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C3497_09665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3497_09735	COG3609	addiction module antidote protein, CC2985 family
C3497_09750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3497_09840	COG3617	BRO family, N-terminal domain
C3497_09910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3497_09920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C3497_09930	COG2217	Heavy metal translocating P-type atpase
C3497_09945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3497_09950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3497_09960	COG3094	Invasion gene expression up-regulator, SirB
C3497_09975	COG3243	poly(R)-hydroxyalkanoic acid synthase
C3497_10020	COG3278	Belongs to the heme-copper respiratory oxidase family
C3497_10030	COG2217	Heavy metal translocating P-type atpase
C3497_10045	COG0489	protein tyrosine kinase activity
C3497_10050	COG3047	cAMP biosynthetic process
C3497_10050	COG2885	chlorophyll binding
C3497_10055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3497_10055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3497_10060	COG0659	secondary active sulfate transmembrane transporter activity
C3497_10065	COG1254	Belongs to the acylphosphatase family
C3497_10080	COG0281	malic enzyme
C3497_10080	COG0280	phosphate acetyltransferase
C3497_10105	COG1450	Type ii and iii secretion system protein
C3497_10120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3497_10125	COG1459	type II secretion system
C3497_10135	COG4969	Belongs to the N-Me-Phe pilin family
C3497_10145	COG4968	Prepilin-type N-terminal cleavage methylation domain
C3497_10170	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C3497_10175	COG0210	DNA helicase
C3497_10185	COG0495	leucyl-tRNA aminoacylation
C3497_10195	COG1466	dna polymerase III delta subunit
C3497_10200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3497_10210	COG4974	Belongs to the 'phage' integrase family
C3497_10215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3497_10225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3497_10230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3497_10235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3497_10260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3497_10270	COG4536	flavin adenine dinucleotide binding
C3497_10285	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C3497_10300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3497_10330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3497_10370	COG0318	PFAM AMP-dependent synthetase and ligase
C3497_10395	COG1216	Glycosyl transferase, family 2
C3497_10395	COG1442	glycosyl transferase family 8
C3497_10400	COG0297	glycogen (starch) synthase activity
C3497_10400	COG0438	transferase activity, transferring glycosyl groups
C3497_10405	COG0463	Glycosyl transferase, family 2
C3497_10405	COG1216	Glycosyl transferase, family 2
C3497_10430	COG0438	transferase activity, transferring glycosyl groups
C3497_10435	COG0297	glycogen (starch) synthase activity
C3497_10440	COG0367	asparagine synthase
C3497_10445	COG0438	transferase activity, transferring glycosyl groups
C3497_10475	COG3267	Type II secretory pathway component ExeA
C3497_10475	COG3409	Peptidoglycan-binding domain 1 protein
C3497_10485	COG0489	protein tyrosine kinase activity
C3497_10510	COG0577	efflux transmembrane transporter activity
C3497_10510	COG1136	(ABC) transporter
C3497_10530	COG0300	oxidoreductase activity
C3497_10550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C3497_10565	COG1469	GTP cyclohydrolase I activity
C3497_10580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3497_10605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3497_10615	COG0134	indole-3-glycerol-phosphate synthase activity
C3497_10620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3497_10635	COG0583	DNA-binding transcription factor activity
C3497_10710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3497_10715	COG0501	Belongs to the peptidase M48B family
C3497_10730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3497_10740	COG0542	response to heat
C3497_10745	COG0071	Belongs to the small heat shock protein (HSP20) family
C3497_10765	COG2188	Transcriptional regulator
C3497_10775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C3497_10800	COG3627	carbon phosphorus lyase activity
C3497_10805	COG4107	phosphonate C-P lyase system protein PhnK
C3497_10810	COG4778	phosphonate C-P lyase system protein PhnL
C3497_10815	COG3454	Phosphonate metabolism
C3497_10820	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C3497_10825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3497_10845	COG3172	ATPase kinase involved in NAD metabolism
C3497_10845	COG1056	cytidyltransferase-related domain
C3497_10850	COG2856	Zn peptidase
C3497_10885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3497_10970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3497_10975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3497_10995	COG2132	Multicopper oxidase
C3497_11020	COG5002	protein histidine kinase activity
C3497_11100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3497_11110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3497_11125	COG1196	nuclear chromosome segregation
C3497_11195	COG2003	Belongs to the UPF0758 family
C3497_11280	COG0582	viral genome integration into host DNA
C3497_11285	COG3246	L-lysine catabolic process to acetate
C3497_11290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3497_11300	COG0546	phosphoglycolate phosphatase activity
C3497_11310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3497_11320	COG1716	ATPase activity
C3497_11325	COG0631	protein serine/threonine phosphatase activity
C3497_11330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C3497_11335	COG0045	succinate-CoA ligase (ADP-forming) activity
C3497_11350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3497_11360	COG0805	protein transport
C3497_11365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3497_11370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3497_11380	COG0140	phosphoribosyl-ATP diphosphatase activity
C3497_11385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3497_11390	COG0107	imidazoleglycerol-phosphate synthase activity
C3497_11395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3497_11400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3497_11405	COG0131	Imidazoleglycerol-phosphate dehydratase
C3497_11410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3497_11415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3497_11420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3497_11425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3497_11435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3497_11445	COG0842	Transport permease protein
C3497_11450	COG1131	(ABC) transporter
C3497_11470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C3497_11475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C3497_11480	COG1127	ABC transporter
C3497_11490	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C3497_11500	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C3497_11505	COG1024	Enoyl-CoA hydratase
C3497_11515	COG0204	Acyl-transferase
C3497_11520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C3497_11525	COG0751	glycine-tRNA ligase activity
C3497_11530	COG0752	glycyl-tRNA synthetase alpha subunit
C3497_11535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C3497_11540	COG4535	Mg2 and Co2 transporter CorC
C3497_11545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3497_11550	COG1702	phosphate starvation-inducible protein PhoH
C3497_11555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3497_11605	COG5433	transposase activity
C3497_11615	COG2154	pterin-4-alpha-carbinolamine dehydratase
C3497_11620	COG0009	L-threonylcarbamoyladenylate synthase
C3497_11625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C3497_11630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3497_11635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3497_11655	COG4566	intracellular signal transduction
C3497_11670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C3497_11675	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3497_11680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3497_11700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3497_11750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C3497_11755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3497_11765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3497_11770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C3497_11775	COG1674	ftsk spoiiie
C3497_11785	COG3039	Transposase
C3497_11790	COG0492	ferredoxin-NADP+ reductase activity
C3497_11795	COG2840	Smr protein MutS2
C3497_11805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3497_11805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3497_11810	COG1982	Orn Lys Arg decarboxylase major
C3497_11815	COG0717	Belongs to the dCTP deaminase family
C3497_11820	COG0583	DNA-binding transcription factor activity
C3497_11825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3497_11835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3497_11855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3497_11865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3497_11870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C3497_11875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3497_11880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C3497_11890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3497_11895	COG0006	proline dipeptidase activity
C3497_11900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3497_11920	COG0151	Belongs to the GarS family
C3497_11925	COG0408	coproporphyrinogen oxidase activity
C3497_11935	COG2959	enzyme of heme biosynthesis
C3497_11945	COG0181	hydroxymethylbilane synthase activity
C3497_11950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C3497_11995	COG0165	Argininosuccinate lyase
C3497_12025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C3497_12035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3497_12040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3497_12050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3497_12075	COG0631	protein serine/threonine phosphatase activity
C3497_12080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3497_12085	COG0653	protein targeting
C3497_12100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C3497_12105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3497_12115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3497_12120	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3497_12125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3497_12130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3497_12135	COG0772	Belongs to the SEDS family
C3497_12140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3497_12145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3497_12150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3497_12155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3497_12170	COG0275	rRNA processing
C3497_12175	COG2001	Belongs to the MraZ family
C3497_12190	COG0418	dihydroorotase activity
C3497_12200	COG0792	nuclease activity
C3497_12205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C3497_12210	COG2823	Periplasmic or secreted lipoprotein
C3497_12215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C3497_12230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3497_12240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3497_12250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3497_12255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3497_12260	COG0511	ligase activity, forming carbon-carbon bonds
C3497_12265	COG0439	Biotin carboxylase
C3497_12270	COG2264	protein methyltransferase activity
C3497_12310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C3497_12340	COG2165	general secretion pathway protein
C3497_12350	COG2165	general secretion pathway protein
C3497_12355	COG1459	type II secretion system
C3497_12360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3497_12370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3497_12385	COG1538	Outer membrane efflux protein
C3497_12390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3497_12395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C3497_12410	COG1918	ferrous iron import across plasma membrane
C3497_12415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3497_12425	COG3338	carbonate dehydratase activity
C3497_12430	COG0351	phosphomethylpyrimidine kinase
C3497_12435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3497_12455	COG3150	esterase
C3497_12460	COG2226	methyltransferase
C3497_12470	COG0557	exoribonuclease II activity
C3497_12480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3497_12485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3497_12490	COG2239	Acts as a magnesium transporter
C3497_12590	COG0305	Participates in initiation and elongation during chromosome replication
C3497_12595	COG0359	binds to the 23S rRNA
C3497_12600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3497_12610	COG0360	Binds together with S18 to 16S ribosomal RNA
C3497_12615	COG1643	Atp-dependent helicase
C3497_12620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3497_12625	COG0668	transmembrane transport
C3497_12630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3497_12645	COG1968	undecaprenyl-diphosphatase activity
C3497_12650	COG2807	transmembrane transport
C3497_12655	COG1187	pseudouridine synthase activity
C3497_12665	COG2212	antiporter activity
C3497_12675	COG0651	ATP synthesis coupled electron transport
C3497_12680	COG1006	Multisubunit Na H antiporter MnhC subunit
C3497_12685	COG2111	Na H antiporter
C3497_12685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3497_12690	COG1414	Transcriptional regulator
C3497_12705	COG0281	malic enzyme
C3497_12705	COG0280	phosphate acetyltransferase
C3497_12710	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C3497_12720	COG0741	lytic transglycosylase activity
C3497_12725	COG3023	N-Acetylmuramoyl-L-alanine amidase
C3497_12735	COG0778	Nitroreductase
C3497_12740	COG1797	cobyrinic acid a,c-diamide synthase activity
C3497_12745	COG1648	precorrin-2 dehydrogenase activity
C3497_12745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3497_12750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C3497_12755	COG4139	cobalamin transport
C3497_12760	COG4206	TonB-dependent receptor
C3497_12770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C3497_12775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C3497_12780	COG0406	alpha-ribazole phosphatase activity
C3497_12785	COG1132	(ABC) transporter
C3497_12790	COG0726	polysaccharide deacetylase
C3497_12795	COG0438	transferase activity, transferring glycosyl groups
C3497_12800	COG0438	transferase activity, transferring glycosyl groups
C3497_12815	COG0438	transferase activity, transferring glycosyl groups
C3497_12820	COG0438	transferase activity, transferring glycosyl groups
C3497_12845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3497_12845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C3497_12860	COG4636	protein conserved in cyanobacteria
C3497_12865	COG0367	asparagine synthase
C3497_12890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3497_12900	COG0110	maltose O-acetyltransferase activity
C3497_12935	COG0436	Aminotransferase
C3497_12940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C3497_12945	COG0235	Class ii aldolase
C3497_12955	COG2084	Dehydrogenase
C3497_12960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3497_12965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C3497_12980	COG1215	transferase activity, transferring glycosyl groups
C3497_12990	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C3497_12995	COG0457	Tetratricopeptide repeat
C3497_13005	COG1032	radical SAM domain protein
C3497_13030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3497_13040	COG3088	subunit of a heme lyase
C3497_13045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3497_13055	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C3497_13075	COG4133	protoheme IX ABC transporter activity
C3497_13080	COG3005	denitrification pathway
C3497_13085	COG3043	anaerobic respiration
C3497_13090	COG0348	domain, Protein
C3497_13095	COG0437	4 iron, 4 sulfur cluster binding
C3497_13100	COG0243	molybdopterin cofactor binding
C3497_13115	COG2197	response regulator
C3497_13120	COG3850	Histidine kinase
C3497_13130	COG5002	protein histidine kinase activity
C3497_13130	COG2176	DNA-directed DNA polymerase activity
C3497_13140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3497_13145	COG1758	RNA polymerase activity
C3497_13150	COG0194	GDP metabolic process
C3497_13155	COG1561	YicC-like family, N-terminal region
C3497_13165	COG0631	protein serine/threonine phosphatase activity
C3497_13170	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3497_13175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3497_13180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3497_13185	COG0616	signal peptide processing
C3497_13190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3497_13195	COG2022	thiamine diphosphate biosynthetic process
C3497_13230	COG0745	RESPONSE REGULATOR receiver
C3497_13240	COG2226	methyltransferase
C3497_13265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3497_13270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3497_13275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3497_13280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3497_13285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3497_13290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3497_13300	COG0356	it plays a direct role in the translocation of protons across the membrane
C3497_13310	COG1475	DNA binding
C3497_13315	COG1192	Involved in chromosome partitioning
C3497_13320	COG0357	Ribosomal RNA small subunit methyltransferase G
C3497_13325	COG0445	tRNA wobble uridine modification
C3497_13330	COG0697	spore germination
C3497_13335	COG2207	Transcriptional regulator
C3497_13345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3497_13350	COG0163	prenyltransferase activity
C3497_13380	COG0420	3'-5' exonuclease activity
C3497_13385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3497_13395	COG4774	siderophore transport
C3497_13425	COG4771	TonB-dependent receptor
C3497_13430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3497_13455	COG4771	TonB-dependent receptor
C3497_13475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C3497_13495	COG4771	TonB-dependent receptor
C3497_13505	COG1136	(ABC) transporter
C3497_13505	COG0577	efflux transmembrane transporter activity
C3497_13510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3497_13515	COG0735	belongs to the Fur family
C3497_13560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3497_13565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C3497_13580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3497_13585	COG1074	ATP-dependent DNA helicase activity
C3497_13590	COG0840	transmembrane signaling receptor activity
C3497_13620	COG2814	Major facilitator Superfamily
C3497_13625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C3497_13630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3497_13635	COG1546	Belongs to the CinA family
C3497_13640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3497_13645	COG2137	regulation of response to DNA damage stimulus
C3497_13650	COG1137	ATPase activity
C3497_13655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C3497_13660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3497_13670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C3497_13680	COG3039	Transposase
C3497_13685	COG3706	GGDEF domain
C3497_13685	COG0745	RESPONSE REGULATOR receiver
C3497_13690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3497_13695	COG3447	MASE1 domain protein
C3497_13695	COG5002	protein histidine kinase activity
C3497_13695	COG5001	Diguanylate cyclase
C3497_13700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3497_13715	COG0617	tRNA 3'-terminal CCA addition
C3497_13740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3497_13745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3497_13780	COG0604	alcohol dehydrogenase
C3497_13785	COG1309	transcriptional regulator
C3497_13790	COG5433	transposase activity
C3497_13795	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C3497_13845	COG2099	Precorrin-6x reductase
C3497_13860	COG2875	Belongs to the precorrin methyltransferase family
C3497_13900	COG0625	glutathione transferase activity
C3497_13915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3497_13920	COG2233	PERMEase
C3497_13930	COG0708	Exodeoxyribonuclease III
C3497_13935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3497_13945	COG0243	molybdopterin cofactor binding
C3497_13960	COG0251	oxidation-reduction process
C3497_13970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3497_13995	COG0410	ABC transporter
C3497_14000	COG0559	Belongs to the binding-protein-dependent transport system permease family
C3497_14015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3497_14020	COG4597	amino acid ABC transporter
C3497_14025	COG0765	amino acid transport
C3497_14030	COG1126	abc transporter atp-binding protein
C3497_14040	COG3876	Protein conserved in bacteria
C3497_14045	COG0659	secondary active sulfate transmembrane transporter activity
C3497_14050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3497_14055	COG0583	DNA-binding transcription factor activity
C3497_14060	COG2814	Major facilitator Superfamily
C3497_14080	COG1857	crispr-associated protein
C3497_14100	COG1518	maintenance of DNA repeat elements
C3497_14105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3497_14145	COG0411	ABC transporter
C3497_14155	COG2814	Major facilitator Superfamily
C3497_14160	COG0606	chelatase, subunit chli
C3497_14175	COG0347	Belongs to the P(II) protein family
C3497_14180	COG0004	ammonium transporteR
C3497_14195	COG0488	(ABC) transporter
C3497_14220	COG0697	spore germination
C3497_14230	COG0189	ligase activity
C3497_14240	COG0827	DNA restriction-modification system
C3497_14240	COG0732	type I restriction modification DNA specificity domain
C3497_14255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3497_14260	COG3706	GGDEF domain
C3497_14270	COG0488	(ABC) transporter
C3497_14285	COG0306	phosphate transporter
C3497_14290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3497_14295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3497_14300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3497_14305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3497_14310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C3497_14310	COG2813	Specifically methylates the guanine in position
C3497_14330	COG0288	reversible hydration of carbon dioxide
C3497_14335	COG1940	carbohydrate kinase activity
C3497_14340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3497_14345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3497_14355	COG0569	domain protein
C3497_14360	COG2204	response regulator
C3497_14365	COG5000	phosphorelay sensor kinase activity
C3497_14375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3497_14375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3497_14380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C3497_14385	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C3497_14395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3497_14400	COG0706	membrane insertase activity
C3497_14405	COG0594	ribonuclease P activity
C3497_14410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3497_14415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3497_14445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3497_14460	COG2974	May be involved in recombination
C3497_14470	COG1187	pseudouridine synthase activity
C3497_14480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3497_14490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3497_14500	COG3909	cytochrome
C3497_14505	COG0840	transmembrane signaling receptor activity
C3497_14510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3497_14515	COG4772	TonB-dependent receptor
C3497_14520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C3497_14530	COG0523	cobalamin synthesis protein
C3497_14535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3497_14540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3497_14545	COG2951	lytic endotransglycosylase activity
C3497_14555	COG0625	glutathione transferase activity
C3497_14560	COG2267	carboxylic ester hydrolase activity
C3497_14580	COG1028	Short-chain dehydrogenase reductase Sdr
C3497_14585	COG0037	tRNA processing
C3497_14615	COG0210	DNA helicase
C3497_14630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3497_14635	COG0321	lipoyl(octanoyl) transferase activity
C3497_14640	COG2921	Belongs to the UPF0250 family
C3497_14650	COG1686	Belongs to the peptidase S11 family
C3497_14660	COG0772	Belongs to the SEDS family
C3497_14665	COG0768	penicillin binding
C3497_14675	COG1792	Involved in formation and maintenance of cell shape
C3497_14680	COG1077	Cell shape determining protein MreB Mrl
C3497_14685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3497_14690	COG0154	amidase activity
C3497_14695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3497_14700	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C3497_14705	COG1305	Transglutaminase-like
C3497_14710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3497_14715	COG0501	Belongs to the peptidase M48B family
C3497_14720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3497_14725	COG0242	peptide deformylase activity
C3497_14730	COG1652	LysM domain
C3497_14735	COG0758	DNA mediated transformation
C3497_14740	COG2922	Belongs to the Smg family
C3497_14750	COG0783	Belongs to the Dps family