locus-tag	class	description
IPMB12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPMB12_00010	COG0592	DNA-directed DNA polymerase activity
IPMB12_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPMB12_00025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPMB12_00035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IPMB12_00040	COG5510	response to toxic substance
IPMB12_00060	COG1438	arginine binding
IPMB12_00070	COG2274	protein secretion by the type I secretion system
IPMB12_00080	COG2816	NAD+ diphosphatase activity
IPMB12_00090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPMB12_00095	COG0594	ribonuclease P activity
IPMB12_00100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPMB12_00105	COG2261	transglycosylase associated protein
IPMB12_00110	COG3622	Belongs to the hyi family
IPMB12_00115	COG0527	aspartate kinase activity
IPMB12_00130	COG0583	DNA-binding transcription factor activity
IPMB12_00145	COG0483	inositol monophosphate 1-phosphatase activity
IPMB12_00150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IPMB12_00155	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IPMB12_00160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPMB12_00175	COG1132	(ABC) transporter
IPMB12_00195	COG3423	Transcriptional regulator
IPMB12_00235	COG0582	viral genome integration into host DNA
IPMB12_00245	COG0343	queuine tRNA-ribosyltransferase activity
IPMB12_00255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPMB12_00260	COG0501	Belongs to the peptidase M48B family
IPMB12_00280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPMB12_00290	COG2861	carbohydrate metabolic process
IPMB12_00295	COG4942	peptidase
IPMB12_00300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPMB12_00315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPMB12_00320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPMB12_00325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPMB12_00330	COG0463	Glycosyl transferase, family 2
IPMB12_00340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IPMB12_00345	COG0512	Glutamine amidotransferase of anthranilate synthase
IPMB12_00345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPMB12_00355	COG0133	tryptophan synthase activity
IPMB12_00360	COG0159	tryptophan synthase activity
IPMB12_00380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPMB12_00385	COG1609	Transcriptional regulator
IPMB12_00390	COG0826	peptidase U32
IPMB12_00395	COG0826	peptidase U32
IPMB12_00400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPMB12_00405	COG2166	iron-sulfur cluster assembly
IPMB12_00410	COG2823	Periplasmic or secreted lipoprotein
IPMB12_00420	COG0792	nuclease activity
IPMB12_00425	COG3107	peptidoglycan biosynthetic process
IPMB12_00440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPMB12_00445	COG1702	phosphate starvation-inducible protein PhoH
IPMB12_00450	COG0768	penicillin binding
IPMB12_00455	COG0772	Belongs to the SEDS family
IPMB12_00460	COG1686	Belongs to the peptidase S11 family
IPMB12_00470	COG0367	asparagine synthase
IPMB12_00480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPMB12_00485	COG2388	GCN5-related N-acetyl-transferase
IPMB12_00490	COG0205	6-phosphofructokinase activity
IPMB12_00500	COG0745	RESPONSE REGULATOR receiver
IPMB12_00505	COG2205	protein histidine kinase activity
IPMB12_00510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IPMB12_00515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IPMB12_00520	COG0616	signal peptide processing
IPMB12_00525	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IPMB12_00545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IPMB12_00560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPMB12_00560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IPMB12_00570	COG0861	Integral membrane protein TerC family
IPMB12_00575	COG0431	NADPH-dependent FMN reductase
IPMB12_00580	COG0783	Belongs to the Dps family
IPMB12_00590	COG3852	Histidine kinase
IPMB12_00595	COG0174	glutamine synthetase
IPMB12_00600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPMB12_00610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPMB12_00620	COG0668	transmembrane transport
IPMB12_00625	COG1309	transcriptional regulator
IPMB12_00635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IPMB12_00640	COG2003	Belongs to the UPF0758 family
IPMB12_00645	COG2900	Belongs to the SlyX family
IPMB12_00660	COG0203	ribosomal protein L17
IPMB12_00665	COG0202	RNA polymerase activity
IPMB12_00670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPMB12_00675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPMB12_00680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPMB12_00685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPMB12_00690	COG0201	protein transport
IPMB12_00695	COG0200	Binds to the 23S rRNA
IPMB12_00700	COG1841	ribosomal large subunit assembly
IPMB12_00715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPMB12_00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPMB12_00755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPMB12_00770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPMB12_00775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPMB12_00780	COG0089	rRNA binding
IPMB12_00790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPMB12_00795	COG0051	transcription antitermination factor activity, RNA binding
IPMB12_00805	COG0471	metal ion transport
IPMB12_00805	COG0490	domain, Protein
IPMB12_00810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPMB12_00835	COG2056	Na+-H+ antiporter family
IPMB12_00840	COG2027	D-alanyl-D-alanine carboxypeptidase
IPMB12_00860	COG1280	lysine exporter protein (LysE YggA)
IPMB12_00875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPMB12_00880	COG2252	PERMEase
IPMB12_00890	COG0653	protein targeting
IPMB12_00910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPMB12_00925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPMB12_00935	COG1862	Preprotein translocase
IPMB12_00940	COG1007	ATP synthesis coupled electron transport
IPMB12_00945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPMB12_00950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPMB12_00955	COG0713	ATP synthesis coupled electron transport
IPMB12_00965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IPMB12_00975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPMB12_00985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPMB12_00995	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IPMB12_01000	COG3201	nicotinamide mononucleotide transporter
IPMB12_01005	COG0737	Belongs to the 5'-nucleotidase family
IPMB12_01010	COG3850	Histidine kinase
IPMB12_01015	COG2197	response regulator
IPMB12_01025	COG2116	formate transmembrane transporter activity
IPMB12_01030	COG2146	nitrite reductase [NAD(P)H] activity
IPMB12_01035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IPMB12_01045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPMB12_01060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IPMB12_01065	COG1611	Belongs to the LOG family
IPMB12_01070	COG1448	Aminotransferase
IPMB12_01075	COG0534	Mate efflux family protein
IPMB12_01090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IPMB12_01110	COG2169	Transcriptional regulator
IPMB12_01110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPMB12_01115	COG0442	prolyl-tRNA aminoacylation
IPMB12_01120	COG0483	inositol monophosphate 1-phosphatase activity
IPMB12_01155	COG1509	lysine 2,3-aminomutase activity
IPMB12_01160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPMB12_01170	COG4974	Belongs to the 'phage' integrase family
IPMB12_01175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPMB12_01180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPMB12_01185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPMB12_01190	COG0488	(ABC) transporter
IPMB12_01200	COG2814	Major facilitator Superfamily
IPMB12_01225	COG2186	Transcriptional regulator
IPMB12_01230	COG0246	Mannitol dehydrogenase
IPMB12_01235	COG1904	glucuronate isomerase
IPMB12_01240	COG2271	Major facilitator Superfamily
IPMB12_01255	COG2376	Dihydroxyacetone kinase
IPMB12_01275	COG1760	l-serine dehydratase
IPMB12_01280	COG3949	Membrane
IPMB12_01300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPMB12_01320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_01330	COG2190	(PTS) system
IPMB12_01340	COG0166	Belongs to the GPI family
IPMB12_01345	COG0271	Belongs to the BolA IbaG family
IPMB12_01355	COG0646	methionine synthase
IPMB12_01355	COG1410	methionine synthase
IPMB12_01365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPMB12_01370	COG2207	Transcriptional regulator
IPMB12_01380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_01380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPMB12_01380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_01385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPMB12_01390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPMB12_01395	COG1882	Formate acetyltransferase
IPMB12_01400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IPMB12_01405	COG2376	Dihydroxyacetone kinase
IPMB12_01410	COG1461	Dihydroxyacetone kinase
IPMB12_01425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_01435	COG2376	Dihydroxyacetone kinase
IPMB12_01450	COG3775	system Galactitol-specific IIC component
IPMB12_01455	COG3414	Phosphotransferase system galactitol-specific IIB component
IPMB12_01480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPMB12_01485	COG0545	Peptidyl-prolyl cis-trans isomerase
IPMB12_01495	COG2923	Belongs to the DsrF TusC family
IPMB12_01520	COG0528	UMP kinase activity
IPMB12_01540	COG0242	peptide deformylase activity
IPMB12_01545	COG0758	DNA mediated transformation
IPMB12_01555	COG0561	phosphatase activity
IPMB12_01570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IPMB12_01585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPMB12_01585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPMB12_01595	COG3084	Protein conserved in bacteria
IPMB12_01600	COG0746	molybdenum cofactor guanylyltransferase activity
IPMB12_01605	COG1763	Mo-molybdopterin cofactor biosynthetic process
IPMB12_01635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPMB12_01640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IPMB12_01645	COG0583	DNA-binding transcription factor activity
IPMB12_01650	COG1584	GPR1 FUN34 yaaH family protein
IPMB12_01655	COG0443	Heat shock 70 kDa protein
IPMB12_01665	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IPMB12_01665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IPMB12_01670	COG1447	Phosphotransferase system cellobiose-specific component IIA
IPMB12_01680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IPMB12_01690	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IPMB12_01695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IPMB12_01705	COG0802	atpase or kinase
IPMB12_01710	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPMB12_01715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPMB12_01720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPMB12_01725	COG1923	regulation of RNA biosynthetic process
IPMB12_01730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPMB12_01735	COG0330	HflC and HflK could
IPMB12_01740	COG0330	HflC and HflK could
IPMB12_01765	COG2233	PERMEase
IPMB12_01785	COG0154	amidase activity
IPMB12_01800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IPMB12_01830	COG0745	RESPONSE REGULATOR receiver
IPMB12_01835	COG2205	protein histidine kinase activity
IPMB12_01855	COG1971	Probably functions as a manganese efflux pump
IPMB12_01865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPMB12_01880	COG1609	Transcriptional regulator
IPMB12_01885	COG0673	inositol 2-dehydrogenase activity
IPMB12_01890	COG1082	Xylose isomerase domain protein TIM barrel
IPMB12_01895	COG2271	Major facilitator Superfamily
IPMB12_01900	COG3265	gluconokinase activity
IPMB12_01910	COG4807	Protein conserved in bacteria
IPMB12_01915	COG4993	Dehydrogenase
IPMB12_01920	COG0402	S-adenosylhomocysteine deaminase activity
IPMB12_01925	COG0549	Belongs to the carbamate kinase family
IPMB12_01935	COG1304	FMN binding
IPMB12_01940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IPMB12_01945	COG0666	response to abiotic stimulus
IPMB12_01950	COG0583	DNA-binding transcription factor activity
IPMB12_01955	COG4565	transcriptional regulatory protein
IPMB12_01960	COG2205	protein histidine kinase activity
IPMB12_01965	COG0745	RESPONSE REGULATOR receiver
IPMB12_01975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPMB12_02005	COG0754	glutathionylspermidine amidase activity
IPMB12_02015	COG3111	PFAM Bacterial OB fold (BOF) protein
IPMB12_02020	COG2070	2-Nitropropane dioxygenase
IPMB12_02035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IPMB12_02040	COG2204	response regulator
IPMB12_02050	COG2271	Major facilitator Superfamily
IPMB12_02060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPMB12_02065	COG0022	dehydrogenase e1 component
IPMB12_02065	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPMB12_02070	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPMB12_02075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPMB12_02080	COG2084	Dehydrogenase
IPMB12_02085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IPMB12_02090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPMB12_02095	COG2213	PTS system mannitol-specific
IPMB12_02100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_02105	COG0246	Mannitol dehydrogenase
IPMB12_02110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPMB12_02160	COG3111	PFAM Bacterial OB fold (BOF) protein
IPMB12_02165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPMB12_02170	COG0151	Belongs to the GarS family
IPMB12_02180	COG1929	Belongs to the glycerate kinase type-1 family
IPMB12_02185	COG2084	Dehydrogenase
IPMB12_02195	COG4948	Mandelate Racemase Muconate Lactonizing
IPMB12_02200	COG4948	Mandelate Racemase Muconate Lactonizing
IPMB12_02205	COG2271	Major facilitator Superfamily
IPMB12_02210	COG2721	sulfolactate sulfo-lyase activity
IPMB12_02215	COG0488	(ABC) transporter
IPMB12_02230	COG0569	domain protein
IPMB12_02245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPMB12_02260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPMB12_02270	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IPMB12_02275	COG0352	thiamine-phosphate diphosphorylase activity
IPMB12_02280	COG0351	phosphomethylpyrimidine kinase
IPMB12_02285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IPMB12_02290	COG0477	Major facilitator Superfamily
IPMB12_02295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPMB12_02300	COG0081	regulation of translation
IPMB12_02310	COG0222	ribosome binding
IPMB12_02320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPMB12_02340	COG0575	Belongs to the CDS family
IPMB12_02345	COG0750	zinc metalloprotease
IPMB12_02350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPMB12_02355	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IPMB12_02360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPMB12_02375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPMB12_02380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPMB12_02385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPMB12_02390	COG1555	photosystem II stabilization
IPMB12_02395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IPMB12_02410	COG0285	dihydrofolate synthase activity
IPMB12_02415	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IPMB12_02420	COG1286	toxin biosynthetic process
IPMB12_02425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPMB12_02430	COG0163	prenyltransferase activity
IPMB12_02450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPMB12_02465	COG0626	cystathionine gamma-synthase activity
IPMB12_02475	COG0254	rRNA binding
IPMB12_02480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPMB12_02485	COG1720	tRNA m6t6A37 methyltransferase activity
IPMB12_02500	COG1464	Belongs to the NlpA lipoprotein family
IPMB12_02510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IPMB12_02515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IPMB12_02550	COG0494	nUDIX hydrolase
IPMB12_02555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPMB12_02570	COG0604	alcohol dehydrogenase
IPMB12_02575	COG1570	exodeoxyribonuclease VII activity
IPMB12_02580	COG0708	Exodeoxyribonuclease III
IPMB12_02585	COG2095	MarC family integral membrane protein
IPMB12_02590	COG0287	Prephenate dehydrogenase
IPMB12_02590	COG1605	Chorismate mutase
IPMB12_02595	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPMB12_02600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IPMB12_02605	COG1846	Transcriptional regulator
IPMB12_02605	COG1940	carbohydrate kinase activity
IPMB12_02610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPMB12_02620	COG2190	(PTS) system
IPMB12_02620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPMB12_02620	COG1263	PTS System
IPMB12_02640	COG3708	Transcriptional regulator
IPMB12_02640	COG2207	Transcriptional regulator
IPMB12_02645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IPMB12_02645	COG0316	Belongs to the HesB IscA family
IPMB12_02660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPMB12_02680	COG0037	tRNA processing
IPMB12_02695	COG2177	Part of the ABC transporter FtsEX involved in
IPMB12_02700	COG2884	Cell division ATP-binding protein ftsE
IPMB12_02715	COG1959	2 iron, 2 sulfur cluster binding
IPMB12_02725	COG0822	iron-sulfur transferase activity
IPMB12_02730	COG0316	Belongs to the HesB IscA family
IPMB12_02735	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IPMB12_02745	COG0633	Ferredoxin
IPMB12_02755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPMB12_02760	COG0505	Belongs to the CarA family
IPMB12_02770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IPMB12_02780	COG3732	PTS system glucitol sorbitol-specific
IPMB12_02785	COG3730	PTS system glucitol sorbitol-specific
IPMB12_02800	COG2390	Transcriptional regulator
IPMB12_02805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IPMB12_02810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IPMB12_02820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPMB12_02825	COG1534	Rna-binding protein
IPMB12_02835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPMB12_02840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPMB12_02850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPMB12_02855	COG0356	it plays a direct role in the translocation of protons across the membrane
IPMB12_02865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPMB12_02875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPMB12_02880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPMB12_02890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPMB12_02895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPMB12_02900	COG2233	PERMEase
IPMB12_02910	COG0439	Biotin carboxylase
IPMB12_02915	COG0511	ligase activity, forming carbon-carbon bonds
IPMB12_02920	COG1077	Cell shape determining protein MreB Mrl
IPMB12_02925	COG1792	Involved in formation and maintenance of cell shape
IPMB12_02930	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IPMB12_02940	COG0312	modulator of DNA gyrase
IPMB12_02945	COG0586	Pfam SNARE associated Golgi protein
IPMB12_02955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPMB12_02965	COG1397	ADP-ribosylglycohydrolase
IPMB12_02970	COG2188	Transcriptional regulator
IPMB12_02975	COG0659	secondary active sulfate transmembrane transporter activity
IPMB12_02985	COG1490	D-aminoacyl-tRNA deacylase activity
IPMB12_02990	COG1295	ribonuclease BN
IPMB12_02995	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IPMB12_03000	COG0268	Binds directly to 16S ribosomal RNA
IPMB12_03005	COG0126	phosphoglycerate kinase activity
IPMB12_03015	COG2840	Smr protein MutS2
IPMB12_03020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPMB12_03030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPMB12_03040	COG1426	Protein conserved in bacteria
IPMB12_03050	COG0124	histidyl-tRNA synthetase
IPMB12_03055	COG2976	Protein conserved in bacteria
IPMB12_03060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPMB12_03065	COG1160	GTP binding
IPMB12_03080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPMB12_03085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPMB12_03090	COG0497	DNA recombination
IPMB12_03105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IPMB12_03145	COG0589	response to stress
IPMB12_03150	COG0306	phosphate transporter
IPMB12_03155	COG0385	Bile acid
IPMB12_03160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPMB12_03165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPMB12_03170	COG0358	DNA primase activity
IPMB12_03175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPMB12_03180	COG2194	sulfuric ester hydrolase activity
IPMB12_03190	COG3383	formate dehydrogenase (NAD+) activity
IPMB12_03195	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPMB12_03200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPMB12_03200	COG0493	'glutamate synthase
IPMB12_03210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IPMB12_03215	COG1053	succinate dehydrogenase
IPMB12_03220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPMB12_03225	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IPMB12_03235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPMB12_03240	COG1047	Peptidyl-prolyl cis-trans
IPMB12_03250	COG2937	Belongs to the GPAT DAPAT family
IPMB12_03270	COG3150	esterase
IPMB12_03275	COG0187	DNA topoisomerase II activity
IPMB12_03285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IPMB12_03295	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IPMB12_03310	COG3842	ATPase activity
IPMB12_03315	COG1178	ABC-type Fe3 transport system permease component
IPMB12_03320	COG3842	ATPase activity
IPMB12_03370	COG0142	geranyltranstransferase activity
IPMB12_03380	COG0006	proline dipeptidase activity
IPMB12_03395	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPMB12_03400	COG0560	Phosphoserine phosphatase
IPMB12_03405	COG1113	amino acid transport
IPMB12_03410	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IPMB12_03415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IPMB12_03430	COG1012	belongs to the aldehyde dehydrogenase family
IPMB12_03430	COG1454	alcohol dehydrogenase
IPMB12_03440	COG0346	lactoylglutathione lyase activity
IPMB12_03470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IPMB12_03475	COG1575	Belongs to the MenA family. Type 1 subfamily
IPMB12_03495	COG1252	NADH dehydrogenase
IPMB12_03500	COG0250	Participates in transcription elongation, termination and antitermination
IPMB12_03515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPMB12_03520	COG0049	tRNA binding
IPMB12_03530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPMB12_03540	COG1760	l-serine dehydratase
IPMB12_03545	COG0814	amino acid
IPMB12_03565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPMB12_03565	COG4651	solute:proton antiporter activity
IPMB12_03575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPMB12_03580	COG4172	Belongs to the ABC transporter superfamily
IPMB12_03590	COG4171	peptide transport system, permease
IPMB12_03595	COG4168	peptide transport system, permease
IPMB12_03600	COG1530	ribonuclease E activity
IPMB12_03605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPMB12_03610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPMB12_03620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPMB12_03625	COG4221	oxidoreductase activity
IPMB12_03645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IPMB12_03650	COG0330	HflC and HflK could
IPMB12_03655	COG1585	Membrane protein implicated in regulation of membrane protease activity
IPMB12_03660	COG0747	negative chemotaxis
IPMB12_03665	COG0601	transmembrane transport
IPMB12_03670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPMB12_03675	COG0444	Belongs to the ABC transporter superfamily
IPMB12_03680	COG4608	Belongs to the ABC transporter superfamily
IPMB12_03685	COG1666	GTP binding
IPMB12_03700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPMB12_03710	COG0730	response to heat
IPMB12_03720	COG3025	triphosphatase activity
IPMB12_03745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPMB12_03750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPMB12_03750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPMB12_03780	COG3964	amidohydrolase
IPMB12_03795	COG3711	transcriptional antiterminator
IPMB12_03795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_03810	COG1399	metal-binding, possibly nucleic acid-binding protein
IPMB12_03820	COG0416	fatty acid biosynthetic process
IPMB12_03825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPMB12_03830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPMB12_03835	COG1028	Short-chain dehydrogenase reductase Sdr
IPMB12_03845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPMB12_03855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IPMB12_03860	COG0084	hydrolase, TatD family'
IPMB12_03870	COG0477	Major facilitator Superfamily
IPMB12_03875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPMB12_03900	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPMB12_03910	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPMB12_03915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPMB12_03955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPMB12_03960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPMB12_03965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPMB12_03970	COG0470	DNA polymerase III
IPMB12_03990	COG0284	orotidine-5'-phosphate decarboxylase activity
IPMB12_03995	COG0023	Translation Initiation Factor
IPMB12_04005	COG2721	sulfolactate sulfo-lyase activity
IPMB12_04030	COG0477	Major facilitator Superfamily
IPMB12_04040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPMB12_04045	COG2226	methyltransferase
IPMB12_04050	COG0066	3-isopropylmalate dehydratase activity
IPMB12_04065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPMB12_04070	COG3835	regulator
IPMB12_04075	COG4172	Belongs to the ABC transporter superfamily
IPMB12_04080	COG4239	(ABC) transporter, permease
IPMB12_04085	COG4174	ABC transporter (Permease)
IPMB12_04090	COG4166	transmembrane transport
IPMB12_04095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPMB12_04100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IPMB12_04105	COG4988	ABC transporter
IPMB12_04110	COG0492	ferredoxin-NADP+ reductase activity
IPMB12_04125	COG0778	Nitroreductase
IPMB12_04130	COG2814	Major facilitator Superfamily
IPMB12_04135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPMB12_04140	COG4771	TonB-dependent receptor
IPMB12_04145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IPMB12_04150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IPMB12_04185	COG4796	Type ii and iii secretion system protein
IPMB12_04190	COG0561	phosphatase activity
IPMB12_04195	COG0425	Belongs to the sulfur carrier protein TusA family
IPMB12_04200	COG0363	glucosamine-6-phosphate deaminase activity
IPMB12_04205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPMB12_04215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IPMB12_04225	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IPMB12_04230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPMB12_04235	COG0142	geranyltranstransferase activity
IPMB12_04250	COG0729	surface antigen
IPMB12_04255	COG2911	Protein conserved in bacteria
IPMB12_04265	COG3691	Protein conserved in bacteria
IPMB12_04270	COG2062	phosphohistidine phosphatase, SixA
IPMB12_04275	COG1074	ATP-dependent DNA helicase activity
IPMB12_04290	COG3116	cell division
IPMB12_04295	COG0768	penicillin binding
IPMB12_04305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPMB12_04315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPMB12_04320	COG0772	Belongs to the SEDS family
IPMB12_04325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPMB12_04330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPMB12_04340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IPMB12_04345	COG0849	cell division
IPMB12_04350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPMB12_04360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IPMB12_04370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IPMB12_04380	COG2985	domain, Protein
IPMB12_04385	COG0076	glutamate decarboxylase activity
IPMB12_04395	COG1393	Belongs to the ArsC family
IPMB12_04400	COG0735	belongs to the Fur family
IPMB12_04410	COG2867	negative regulation of translational initiation
IPMB12_04435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPMB12_04445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPMB12_04465	COG0582	viral genome integration into host DNA
IPMB12_04545	COG0270	DNA (cytosine-5-)-methyltransferase activity
IPMB12_04550	COG3727	T/G mismatch-specific endonuclease activity
IPMB12_04640	COG1528	Iron-storage protein
IPMB12_04690	COG3716	PTS system mannose fructose sorbose family IID component
IPMB12_04695	COG3715	PTS system
IPMB12_04700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPMB12_04705	COG2222	sugar isomerase
IPMB12_04710	COG1349	DNA-binding transcription factor activity
IPMB12_04715	COG1609	Transcriptional regulator
IPMB12_04720	COG1285	pathogenesis
IPMB12_04725	COG2211	Major facilitator Superfamily
IPMB12_04735	COG0149	triose-phosphate isomerase activity
IPMB12_04740	COG2390	Transcriptional regulator
IPMB12_04745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPMB12_04750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IPMB12_04755	COG0307	riboflavin synthase, alpha
IPMB12_04770	COG4221	oxidoreductase activity
IPMB12_04775	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IPMB12_04780	COG3180	Ammonia monooxygenase
IPMB12_04785	COG2999	glutathione oxidoreductase activity
IPMB12_04830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPMB12_04835	COG0585	pseudouridine synthase activity
IPMB12_04840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPMB12_04855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPMB12_04860	COG1349	DNA-binding transcription factor activity
IPMB12_04865	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_04870	COG1028	Short-chain dehydrogenase reductase Sdr
IPMB12_04885	COG3730	PTS system glucitol sorbitol-specific
IPMB12_04890	COG1349	DNA-binding transcription factor activity
IPMB12_04895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPMB12_04900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IPMB12_04910	COG3091	SprT-like family
IPMB12_04920	COG4206	TonB-dependent receptor
IPMB12_04925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPMB12_04965	COG3085	chromosome segregation
IPMB12_04970	COG0606	chelatase, subunit chli
IPMB12_04975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPMB12_04985	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IPMB12_04990	COG0739	heme binding
IPMB12_04995	COG1560	Kdo2-lipid A biosynthetic process
IPMB12_05005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPMB12_05010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPMB12_05035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPMB12_05040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IPMB12_05040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPMB12_05045	COG0347	Belongs to the P(II) protein family
IPMB12_05055	COG3070	regulator of competence-specific genes
IPMB12_05065	COG3118	belongs to the thioredoxin family
IPMB12_05075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IPMB12_05085	COG0602	queuosine metabolic process
IPMB12_05090	COG0288	reversible hydration of carbon dioxide
IPMB12_05100	COG1131	(ABC) transporter
IPMB12_05105	COG0842	Transport permease protein
IPMB12_05115	COG1473	amidohydrolase
IPMB12_05125	COG0800	Aldolase
IPMB12_05130	COG0193	aminoacyl-tRNA hydrolase activity
IPMB12_05135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPMB12_05140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPMB12_05140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IPMB12_05150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPMB12_05155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IPMB12_05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPMB12_05165	COG0859	PFAM glycosyl transferase family 9
IPMB12_05170	COG0859	PFAM glycosyl transferase family 9
IPMB12_05185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPMB12_05190	COG1840	ABC-type Fe3 transport system, periplasmic component
IPMB12_05195	COG1840	ABC-type Fe3 transport system, periplasmic component
IPMB12_05205	COG3842	ATPase activity
IPMB12_05215	COG2271	Major facilitator Superfamily
IPMB12_05220	COG4948	Mandelate Racemase Muconate Lactonizing
IPMB12_05230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPMB12_05245	COG2271	Major facilitator Superfamily
IPMB12_05250	COG0738	Major facilitator superfamily
IPMB12_05265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPMB12_05270	COG0137	argininosuccinate synthase activity
IPMB12_05275	COG0165	Argininosuccinate lyase
IPMB12_05290	COG4452	Inner membrane protein CreD
IPMB12_05300	COG2373	Large extracellular alpha-helical protein
IPMB12_05305	COG4953	penicillin-binding protein 1C
IPMB12_05310	COG0105	UTP biosynthetic process
IPMB12_05315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IPMB12_05325	COG4948	Mandelate Racemase Muconate Lactonizing
IPMB12_05330	COG2271	Major facilitator Superfamily
IPMB12_05335	COG1482	cell wall glycoprotein biosynthetic process
IPMB12_05345	COG3716	PTS system mannose fructose sorbose family IID component
IPMB12_05350	COG3715	PTS system
IPMB12_05360	COG0561	phosphatase activity
IPMB12_05365	COG0861	Integral membrane protein TerC family
IPMB12_05380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPMB12_05385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPMB12_05405	COG0776	regulation of translation
IPMB12_05410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IPMB12_05420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IPMB12_05430	COG0813	purine-nucleoside phosphorylase activity
IPMB12_05435	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IPMB12_05450	COG4145	pantothenate transmembrane transporter activity
IPMB12_05455	COG3924	membrane
IPMB12_05465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPMB12_05470	COG1120	ATPase activity
IPMB12_05475	COG1349	DNA-binding transcription factor activity
IPMB12_05480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IPMB12_05485	COG3395	kinase activity
IPMB12_05490	COG1454	alcohol dehydrogenase
IPMB12_05495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPMB12_05500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPMB12_05505	COG2271	Major facilitator Superfamily
IPMB12_05510	COG1349	DNA-binding transcription factor activity
IPMB12_05515	COG0167	dihydroorotate dehydrogenase activity
IPMB12_05525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPMB12_05540	COG0346	lactoylglutathione lyase activity
IPMB12_05545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPMB12_05555	COG0667	Aldo Keto reductase
IPMB12_05560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPMB12_05565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPMB12_05570	COG3115	cell septum assembly
IPMB12_05575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPMB12_05580	COG1854	S-ribosylhomocysteine lyase activity
IPMB12_05590	COG1942	4-Oxalocrotonate Tautomerase
IPMB12_05600	COG0671	phosphoesterase, PA-phosphatase related
IPMB12_05605	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IPMB12_05610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IPMB12_05615	COG0084	hydrolase, TatD family'
IPMB12_05620	COG0537	adenosine 5'-monophosphoramidase activity
IPMB12_05625	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
IPMB12_05665	COG3306	glycosyltransferase involved in LPS biosynthesis
IPMB12_05675	COG1199	ATP-dependent helicase activity
IPMB12_05690	COG0456	acetyltransferase
IPMB12_05705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IPMB12_05710	COG3842	ATPase activity
IPMB12_05715	COG1176	ABC-type spermidine putrescine transport system, permease component I
IPMB12_05720	COG1177	transmembrane transport
IPMB12_05740	COG0598	Magnesium transport protein CorA
IPMB12_05750	COG0456	acetyltransferase
IPMB12_05755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPMB12_05760	COG0765	amino acid transport
IPMB12_05765	COG1126	abc transporter atp-binding protein
IPMB12_05770	COG2079	MmgE PrpD family protein
IPMB12_05775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPMB12_05810	COG1757	Na H antiporter
IPMB12_05815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IPMB12_05820	COG2115	Belongs to the xylose isomerase family
IPMB12_05825	COG1070	Carbohydrate kinase
IPMB12_05830	COG2207	Transcriptional regulator
IPMB12_05830	COG1609	Transcriptional regulator
IPMB12_05835	COG2017	converts alpha-aldose to the beta-anomer
IPMB12_05850	COG0633	Ferredoxin
IPMB12_05850	COG3217	Mosc domain protein beta barrel domain protein
IPMB12_05855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IPMB12_05870	COG3071	HemY protein
IPMB12_05875	COG2959	enzyme of heme biosynthesis
IPMB12_05890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPMB12_05895	COG2915	High frequency lysogenization protein hflD homolog
IPMB12_05925	COG3074	FtsZ-dependent cytokinesis
IPMB12_05935	COG1160	GTP binding
IPMB12_05940	COG0791	NLP P60 protein
IPMB12_05965	COG1335	isochorismatase
IPMB12_05970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPMB12_05975	COG0494	nUDIX hydrolase
IPMB12_05980	COG1881	PFAM PEBP family protein
IPMB12_06015	COG2255	four-way junction helicase activity
IPMB12_06020	COG5567	small periplasmic lipoprotein
IPMB12_06025	COG0019	diaminopimelate decarboxylase activity
IPMB12_06030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPMB12_06045	COG1011	Hydrolase
IPMB12_06050	COG0210	DNA helicase
IPMB12_06090	COG1473	amidohydrolase
IPMB12_06105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPMB12_06110	COG0561	phosphatase activity
IPMB12_06115	COG0564	pseudouridine synthase activity
IPMB12_06120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPMB12_06130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPMB12_06135	COG3081	Nucleoid-associated protein
IPMB12_06140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IPMB12_06145	COG1289	transmembrane transporter activity
IPMB12_06150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IPMB12_06155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IPMB12_06160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPMB12_06180	COG4964	Belongs to the GSP D family
IPMB12_06235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPMB12_06240	COG1561	YicC-like family, N-terminal region
IPMB12_06245	COG2188	Transcriptional regulator
IPMB12_06255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPMB12_06285	COG1872	DUF167
IPMB12_06290	COG0762	integral membrane protein
IPMB12_06295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IPMB12_06300	COG2805	Type II/IV secretion system protein
IPMB12_06310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPMB12_06320	COG3092	negative regulation of chromosome organization
IPMB12_06325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IPMB12_06340	COG3214	Protein conserved in bacteria
IPMB12_06345	COG0596	Alpha beta hydrolase
IPMB12_06350	COG3468	outer membrane autotransporter barrel domain protein
IPMB12_06360	COG3493	citrate carrier protein
IPMB12_06365	COG0281	malic enzyme
IPMB12_06370	COG3290	protein histidine kinase activity
IPMB12_06375	COG4565	transcriptional regulatory protein
IPMB12_06380	COG0583	DNA-binding transcription factor activity
IPMB12_06405	COG1247	-acetyltransferase
IPMB12_06410	COG3313	Fe-S protein
IPMB12_06415	COG2824	Alkylphosphonate utilization operon protein PhnA
IPMB12_06455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPMB12_06465	COG0450	alkyl hydroperoxide reductase
IPMB12_06470	COG0513	Belongs to the DEAD box helicase family
IPMB12_06500	COG3958	Transketolase
IPMB12_06505	COG3959	Transketolase, thiamine diphosphate binding domain
IPMB12_06510	COG1028	Short-chain dehydrogenase reductase Sdr
IPMB12_06515	COG2271	Major facilitator Superfamily
IPMB12_06520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IPMB12_06530	COG2814	Major facilitator Superfamily
IPMB12_06540	COG2195	Cleaves the N-terminal amino acid of tripeptides
IPMB12_06545	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IPMB12_06550	COG1073	alpha beta
IPMB12_06555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IPMB12_06575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IPMB12_06580	COG0826	peptidase U32
IPMB12_06585	COG1054	Belongs to the UPF0176 family
IPMB12_06610	COG1733	regulation of RNA biosynthetic process
IPMB12_06620	COG0702	epimerase
IPMB12_06640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPMB12_06665	COG0640	Transcriptional regulator
IPMB12_06685	COG1238	metal cluster binding
IPMB12_06695	COG0456	acetyltransferase
IPMB12_06695	COG1846	Transcriptional regulator
IPMB12_06705	COG1162	GTPase activity
IPMB12_06730	COG0798	PFAM Bile acid sodium symporter
IPMB12_06740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPMB12_06755	COG0583	DNA-binding transcription factor activity
IPMB12_06790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPMB12_06800	COG1959	2 iron, 2 sulfur cluster binding
IPMB12_06810	COG1823	symporter activity
IPMB12_06840	COG3209	COG3209 Rhs family protein
IPMB12_06870	COG3209	COG3209 Rhs family protein
IPMB12_06940	COG3209	COG3209 Rhs family protein
IPMB12_07120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPMB12_07160	COG0582	viral genome integration into host DNA
IPMB12_07170	COG3776	membrane
IPMB12_07175	COG0742	ribosomal rna small subunit methyltransferase
IPMB12_07180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPMB12_07195	COG1131	(ABC) transporter
IPMB12_07200	COG0842	Transport permease protein
IPMB12_07205	COG0842	Transport permease protein
IPMB12_07215	COG5002	protein histidine kinase activity
IPMB12_07220	COG0745	RESPONSE REGULATOR receiver
IPMB12_07225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPMB12_07230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPMB12_07235	COG0741	lytic transglycosylase activity
IPMB12_07245	COG1194	a g-specific adenine glycosylase
IPMB12_07250	COG1605	Chorismate mutase
IPMB12_07250	COG0077	Prephenate dehydratase
IPMB12_07255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPMB12_07260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPMB12_07265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPMB12_07285	COG1185	polyribonucleotide nucleotidyltransferase activity
IPMB12_07295	COG0513	Belongs to the DEAD box helicase family
IPMB12_07300	COG4607	ABC-type enterochelin transport system periplasmic component
IPMB12_07320	COG0228	four-way junction DNA binding
IPMB12_07330	COG0336	Belongs to the RNA methyltransferase TrmD family
IPMB12_07340	COG4953	penicillin-binding protein 1C
IPMB12_07345	COG2373	Large extracellular alpha-helical protein
IPMB12_07355	COG2081	HI0933 family
IPMB12_07360	COG0523	cobalamin synthesis protein
IPMB12_07365	COG2879	small protein
IPMB12_07370	COG1966	Carbon starvation protein
IPMB12_07375	COG3279	Response regulator of the LytR AlgR family
IPMB12_07380	COG3275	phosphorelay sensor kinase activity
IPMB12_07390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPMB12_07395	COG0698	ribose 5-phosphate isomerase
IPMB12_07405	COG3395	kinase activity
IPMB12_07420	COG0312	modulator of DNA gyrase
IPMB12_07435	COG0613	PHP domain protein
IPMB12_07450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPMB12_07455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPMB12_07460	COG1758	RNA polymerase activity
IPMB12_07475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPMB12_07480	COG2183	response to ionizing radiation
IPMB12_07485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPMB12_07490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IPMB12_07490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IPMB12_07495	COG1368	sulfuric ester hydrolase activity
IPMB12_07500	COG1979	alcohol dehydrogenase
IPMB12_07510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPMB12_07520	COG1609	Transcriptional regulator
IPMB12_07525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPMB12_07530	COG1879	ABC-type sugar transport system periplasmic component
IPMB12_07535	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPMB12_07540	COG1129	ABC transporter
IPMB12_07555	COG1511	domain protein
IPMB12_07555	COG3264	Mechanosensitive ion channel
IPMB12_07560	COG0586	Pfam SNARE associated Golgi protein
IPMB12_07565	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IPMB12_07575	COG0842	Transport permease protein
IPMB12_07580	COG1129	ABC transporter
IPMB12_07580	COG0842	Transport permease protein
IPMB12_07585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPMB12_07605	COG0826	peptidase U32
IPMB12_07615	COG1760	l-serine dehydratase
IPMB12_07620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPMB12_07625	COG1388	LysM domain
IPMB12_07625	COG4942	peptidase
IPMB12_07640	COG2076	Multidrug Resistance protein
IPMB12_07650	COG1737	Transcriptional regulator
IPMB12_07660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_07660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPMB12_07690	COG0814	amino acid
IPMB12_07695	COG0626	cystathionine gamma-synthase activity
IPMB12_07705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPMB12_07710	COG3956	TIGRFAM MazG family protein
IPMB12_07720	COG3593	DNA synthesis involved in DNA repair
IPMB12_07725	COG0504	CTP synthase activity
IPMB12_07730	COG0148	phosphopyruvate hydratase activity
IPMB12_07740	COG0384	phenazine biosynthesis protein PhzF
IPMB12_07750	COG0542	response to heat
IPMB12_07765	COG0671	phosphoesterase, PA-phosphatase related
IPMB12_07770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPMB12_07780	COG0833	amino acid
IPMB12_07785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPMB12_07790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPMB12_07795	COG1466	dna polymerase III delta subunit
IPMB12_07800	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IPMB12_07805	COG0495	leucyl-tRNA aminoacylation
IPMB12_07820	COG2851	Citrate transporter
IPMB12_07825	COG0583	DNA-binding transcription factor activity
IPMB12_07830	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
IPMB12_07835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IPMB12_07855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPMB12_07865	COG0372	Belongs to the citrate synthase family
IPMB12_07870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPMB12_07880	COG0745	RESPONSE REGULATOR receiver
IPMB12_07885	COG2205	protein histidine kinase activity
IPMB12_07890	COG0628	permease
IPMB12_07895	COG4574	serine-type endopeptidase inhibitor activity
IPMB12_07900	COG1538	Outer membrane efflux protein
IPMB12_07905	COG0494	nUDIX hydrolase
IPMB12_07910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IPMB12_07930	COG2917	probably involved in intracellular septation
IPMB12_07935	COG0735	belongs to the Fur family
IPMB12_07945	COG0045	succinate-CoA ligase (ADP-forming) activity
IPMB12_07950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IPMB12_07955	COG1271	oxidase subunit
IPMB12_07960	COG1294	oxidase, subunit
IPMB12_07965	COG4890	Cyd operon protein YbgT
IPMB12_07970	COG0824	Thioesterase
IPMB12_07975	COG0811	peptide transport
IPMB12_07980	COG0848	biopolymer transport protein
IPMB12_07985	COG3064	Membrane
IPMB12_07990	COG0823	Involved in the tonB-independent uptake of proteins
IPMB12_07995	COG2885	chlorophyll binding
IPMB12_08010	COG0583	DNA-binding transcription factor activity
IPMB12_08015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IPMB12_08015	COG0473	3-isopropylmalate dehydrogenase activity
IPMB12_08020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IPMB12_08025	COG2271	Major facilitator Superfamily
IPMB12_08030	COG1105	Belongs to the carbohydrate kinase PfkB family
IPMB12_08045	COG0076	glutamate decarboxylase activity
IPMB12_08050	COG3468	outer membrane autotransporter barrel domain protein
IPMB12_08060	COG2137	regulation of response to DNA damage stimulus
IPMB12_08070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IPMB12_08095	COG1126	abc transporter atp-binding protein
IPMB12_08100	COG0765	amino acid transport
IPMB12_08105	COG0765	amino acid transport
IPMB12_08115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPMB12_08120	COG4535	Mg2 and Co2 transporter CorC
IPMB12_08125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPMB12_08130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPMB12_08135	COG0799	negative regulation of ribosome biogenesis
IPMB12_08140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPMB12_08150	COG0616	signal peptide processing
IPMB12_08165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPMB12_08170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IPMB12_08180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IPMB12_08185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPMB12_08200	COG3722	fumarate hydratase activity
IPMB12_08210	COG2213	PTS system mannitol-specific
IPMB12_08210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_08225	COG0613	PHP domain protein
IPMB12_08230	COG1263	PTS System
IPMB12_08230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPMB12_08230	COG2190	(PTS) system
IPMB12_08235	COG3711	transcriptional antiterminator
IPMB12_08245	COG1560	Kdo2-lipid A biosynthetic process
IPMB12_08260	COG2819	hydrolase of the alpha beta superfamily
IPMB12_08300	COG1263	PTS System
IPMB12_08300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPMB12_08300	COG2190	(PTS) system
IPMB12_08320	COG0406	alpha-ribazole phosphatase activity
IPMB12_08330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPMB12_08340	COG0765	amino acid transport
IPMB12_08345	COG2223	nitrite transmembrane transporter activity
IPMB12_08350	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPMB12_08355	COG1140	nitrate reductase beta subunit
IPMB12_08360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IPMB12_08365	COG2181	nitrate reductase activity
IPMB12_08375	COG2188	Transcriptional regulator
IPMB12_08390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_08390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IPMB12_08395	COG3715	PTS system
IPMB12_08400	COG3716	PTS system mannose fructose sorbose family IID component
IPMB12_08405	COG0246	Mannitol dehydrogenase
IPMB12_08415	COG2376	Dihydroxyacetone kinase
IPMB12_08420	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IPMB12_08425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IPMB12_08430	COG3154	lipid carrier protein
IPMB12_08435	COG0025	NhaP-type Na H and K H
IPMB12_08445	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IPMB12_08450	COG2252	PERMEase
IPMB12_08460	COG1122	ATPase activity
IPMB12_08465	COG4721	ABC-type cobalt transport system, permease component
IPMB12_08475	COG1322	Protein conserved in bacteria
IPMB12_08505	COG0039	L-malate dehydrogenase activity
IPMB12_08520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPMB12_08530	COG0545	Peptidyl-prolyl cis-trans isomerase
IPMB12_08535	COG0488	(ABC) transporter
IPMB12_08540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPMB12_08545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPMB12_08565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IPMB12_08570	COG1882	Formate acetyltransferase
IPMB12_08580	COG1349	DNA-binding transcription factor activity
IPMB12_08585	COG0004	ammonium transporteR
IPMB12_08590	COG0347	Belongs to the P(II) protein family
IPMB12_08595	COG0067	glutamate synthase
IPMB12_08595	COG0070	glutamate synthase
IPMB12_08595	COG0069	glutamate synthase activity
IPMB12_08600	COG0493	'glutamate synthase
IPMB12_08620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPMB12_08625	COG0800	Aldolase
IPMB12_08635	COG1737	Transcriptional regulator
IPMB12_08640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPMB12_08645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPMB12_08650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPMB12_08665	COG4149	molybdate abc transporter
IPMB12_08670	COG0725	ABC transporter, periplasmic molybdate-binding protein
IPMB12_08675	COG3585	molybdate ion transport
IPMB12_08675	COG2005	Transcriptional regulator
IPMB12_08680	COG1119	ATPase activity
IPMB12_08685	COG0556	nucleotide-excision repair
IPMB12_08690	COG0251	oxidation-reduction process
IPMB12_08700	COG1067	ATP-dependent peptidase activity
IPMB12_08705	COG3083	sulfuric ester hydrolase activity
IPMB12_08710	COG1028	Short-chain dehydrogenase reductase Sdr
IPMB12_08725	COG1414	Transcriptional regulator
IPMB12_08730	COG2731	YhcH YjgK YiaL family protein
IPMB12_08740	COG2223	nitrite transmembrane transporter activity
IPMB12_08755	COG2951	lytic endotransglycosylase activity
IPMB12_08760	COG2983	Belongs to the UPF0260 family
IPMB12_08765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPMB12_08775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPMB12_08780	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPMB12_08785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPMB12_08790	COG5642	Protein of unknown function (DUF2384)
IPMB12_08795	COG5654	RES domain protein
IPMB12_08835	COG0617	tRNA 3'-terminal CCA addition
IPMB12_08840	COG4991	sh3 domain protein
IPMB12_08850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IPMB12_08855	COG0314	molybdopterin synthase activity
IPMB12_08860	COG0670	Belongs to the BI1 family
IPMB12_08865	COG0346	lactoylglutathione lyase activity
IPMB12_08870	COG3133	Outer membrane lipoprotein
IPMB12_08880	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IPMB12_08885	COG0033	Phosphoglucomutase
IPMB12_08890	COG0517	IMP dehydrogenase activity
IPMB12_08890	COG0516	GMP reductase activity
IPMB12_08895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPMB12_08900	COG0494	nUDIX hydrolase
IPMB12_08920	COG3026	antisigma factor binding
IPMB12_08930	COG0681	Belongs to the peptidase S26 family
IPMB12_08940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPMB12_08960	COG3140	Belongs to the UPF0181 family
IPMB12_08970	COG0697	spore germination
IPMB12_08975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPMB12_08980	COG1794	racemase activity, acting on amino acids and derivatives
IPMB12_08985	COG2918	glutathione biosynthetic process
IPMB12_08995	COG1388	LysM domain
IPMB12_08995	COG0741	lytic transglycosylase activity
IPMB12_09000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPMB12_09010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IPMB12_09020	COG3209	COG3209 Rhs family protein
IPMB12_09065	COG2814	Major facilitator Superfamily
IPMB12_09080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPMB12_09085	COG0539	negative regulation of cytoplasmic translation
IPMB12_09090	COG0776	regulation of translation
IPMB12_09095	COG0658	competence protein
IPMB12_09095	COG2333	competence protein COMEC
IPMB12_09105	COG1663	tetraacyldisaccharide 4'-kinase activity
IPMB12_09110	COG2835	tetraacyldisaccharide 4'-kinase activity
IPMB12_09115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IPMB12_09130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IPMB12_09130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IPMB12_09135	COG0418	dihydroorotase activity
IPMB12_09145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPMB12_09150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IPMB12_09155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPMB12_09160	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IPMB12_09170	COG0237	dephospho-CoA kinase activity
IPMB12_09185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPMB12_09190	COG4969	Belongs to the N-Me-Phe pilin family
IPMB12_09195	COG2321	neutral zinc metallopeptidase
IPMB12_09200	COG3023	N-Acetylmuramoyl-L-alanine amidase
IPMB12_09205	COG3384	dioxygenase
IPMB12_09215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPMB12_09220	COG0564	pseudouridine synthase activity
IPMB12_09225	COG1496	oxidoreductase activity
IPMB12_09230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPMB12_09235	COG1349	DNA-binding transcription factor activity
IPMB12_09250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPMB12_09250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_09250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPMB12_09255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_09255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPMB12_09260	COG0737	Belongs to the 5'-nucleotidase family
IPMB12_09265	COG3713	MltA-interacting MipA family protein
IPMB12_09275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPMB12_09280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPMB12_09295	COG0564	pseudouridine synthase activity
IPMB12_09300	COG0406	alpha-ribazole phosphatase activity
IPMB12_09305	COG1811	Na channel or pump
IPMB12_09310	COG4783	chaperone-mediated protein folding
IPMB12_09315	COG0116	Belongs to the methyltransferase superfamily
IPMB12_09315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IPMB12_09320	COG0488	(ABC) transporter
IPMB12_09325	COG2995	paraquat-inducible protein a
IPMB12_09330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IPMB12_09330	COG3008	intermembrane lipid transfer
IPMB12_09335	COG3009	Protein conserved in bacteria
IPMB12_09345	COG2850	peptidyl-arginine hydroxylation
IPMB12_09355	COG1802	Transcriptional regulator
IPMB12_09360	COG2814	Major facilitator Superfamily
IPMB12_09375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPMB12_09380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPMB12_09385	COG1414	Transcriptional regulator
IPMB12_09400	COG0625	glutathione transferase activity
IPMB12_09405	COG2969	positive regulation of protein catabolic process
IPMB12_09410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPMB12_09420	COG1028	Short-chain dehydrogenase reductase Sdr
IPMB12_09425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IPMB12_09430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPMB12_09435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IPMB12_09440	COG3012	SEC-C Motif Domain Protein
IPMB12_09445	COG2431	L-lysine efflux transmembrane transporter activity
IPMB12_09450	COG2990	Protein conserved in bacteria
IPMB12_09455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPMB12_09460	COG0542	response to heat
IPMB12_09465	COG0644	oxidoreductase
IPMB12_09480	COG0742	ribosomal rna small subunit methyltransferase
IPMB12_09485	COG1187	pseudouridine synthase activity
IPMB12_09490	COG2814	Major facilitator Superfamily
IPMB12_09495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IPMB12_09500	COG3107	peptidoglycan biosynthetic process
IPMB12_09500	COG1674	ftsk spoiiie
IPMB12_09505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IPMB12_09510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPMB12_09525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IPMB12_09535	COG1882	Formate acetyltransferase
IPMB12_09540	COG2116	formate transmembrane transporter activity
IPMB12_09550	COG1944	ATP diphosphatase activity
IPMB12_09560	COG2860	membrane
IPMB12_09565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IPMB12_09570	COG0300	oxidoreductase activity
IPMB12_09575	COG3118	belongs to the thioredoxin family
IPMB12_09580	COG1297	OPT oligopeptide transporter protein
IPMB12_09590	COG0679	Auxin Efflux Carrier
IPMB12_09595	COG3022	response to hydroperoxide
IPMB12_09605	COG3111	PFAM Bacterial OB fold (BOF) protein
IPMB12_09615	COG3978	acetolactate synthase activity
IPMB12_09620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IPMB12_09625	COG0129	dihydroxy-acid dehydratase activity
IPMB12_09635	COG0673	inositol 2-dehydrogenase activity
IPMB12_09640	COG1473	amidohydrolase
IPMB12_09655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPMB12_09665	COG0747	negative chemotaxis
IPMB12_09670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IPMB12_09675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IPMB12_09685	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IPMB12_09705	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IPMB12_09710	COG0642	Histidine kinase
IPMB12_09715	COG0745	RESPONSE REGULATOR receiver
IPMB12_09720	COG2194	sulfuric ester hydrolase activity
IPMB12_09725	COG0671	phosphoesterase, PA-phosphatase related
IPMB12_09740	COG1393	Belongs to the ArsC family
IPMB12_09745	COG1671	Belongs to the UPF0178 family
IPMB12_09750	COG0028	Belongs to the TPP enzyme family
IPMB12_09755	COG0440	acetolactate synthase activity
IPMB12_09785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IPMB12_09800	COG0012	GTP binding
IPMB12_09805	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IPMB12_09825	COG0140	phosphoribosyl-ATP diphosphatase activity
IPMB12_09825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPMB12_09840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPMB12_09845	COG0131	Imidazoleglycerol-phosphate dehydratase
IPMB12_09845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IPMB12_09855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPMB12_09860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPMB12_09865	COG0433	COG0433 Predicted ATPase
IPMB12_09890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPMB12_09900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPMB12_09915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPMB12_09920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPMB12_09925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPMB12_09930	COG1678	Uncharacterized ACR, COG1678
IPMB12_09935	COG0189	ligase activity
IPMB12_09940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IPMB12_09945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IPMB12_09950	COG4977	sequence-specific DNA binding
IPMB12_09955	COG4977	sequence-specific DNA binding
IPMB12_09955	COG1917	Cupin 2, conserved barrel domain protein
IPMB12_09965	COG0235	Class ii aldolase
IPMB12_09975	COG3775	system Galactitol-specific IIC component
IPMB12_09980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPMB12_09985	COG1454	alcohol dehydrogenase
IPMB12_09995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPMB12_10000	COG0534	Mate efflux family protein
IPMB12_10005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPMB12_10005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPMB12_10005	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPMB12_10005	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPMB12_10025	COG0604	alcohol dehydrogenase
IPMB12_10040	COG0656	L-ascorbic acid biosynthetic process
IPMB12_10050	COG0513	Belongs to the DEAD box helicase family
IPMB12_10055	COG3246	L-lysine catabolic process to acetate
IPMB12_10060	COG2814	Major facilitator Superfamily
IPMB12_10065	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IPMB12_10075	COG0673	inositol 2-dehydrogenase activity
IPMB12_10080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPMB12_10090	COG0583	DNA-binding transcription factor activity
IPMB12_10100	COG3468	outer membrane autotransporter barrel domain protein
IPMB12_10110	COG0488	(ABC) transporter
IPMB12_10115	COG3038	cytochrome b561
IPMB12_10125	COG0095	Lipoate-protein ligase
IPMB12_10170	COG2986	histidine ammonia-lyase
IPMB12_10190	COG0814	amino acid
IPMB12_10200	COG0513	Belongs to the DEAD box helicase family
IPMB12_10215	COG0795	lipopolysaccharide-transporting ATPase activity
IPMB12_10220	COG0795	lipopolysaccharide-transporting ATPase activity
IPMB12_10230	COG2927	DNA polymerase III (CHI subunit)
IPMB12_10245	COG4993	Dehydrogenase
IPMB12_10250	COG2831	hemolysin activation secretion protein
IPMB12_10260	COG3210	domain, Protein
IPMB12_10260	COG3210	domain, Protein
IPMB12_10290	COG3210	domain, Protein
IPMB12_10320	COG0583	DNA-binding transcription factor activity
IPMB12_10325	COG0183	Belongs to the thiolase family
IPMB12_10330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IPMB12_10340	COG1349	DNA-binding transcription factor activity
IPMB12_10350	COG1515	deoxyribonuclease V activity
IPMB12_10365	COG2226	methyltransferase
IPMB12_10370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPMB12_10375	COG1114	Component of the transport system for branched-chain amino acids
IPMB12_10385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IPMB12_10395	COG1028	Short-chain dehydrogenase reductase Sdr
IPMB12_10400	COG0704	Plays a role in the regulation of phosphate uptake
IPMB12_10410	COG0581	inorganic phosphate transmembrane transporter activity
IPMB12_10415	COG0573	inorganic phosphate transmembrane transporter activity
IPMB12_10420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPMB12_10425	COG5002	protein histidine kinase activity
IPMB12_10445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPMB12_10450	COG2304	oxidoreductase activity
IPMB12_10460	COG5002	protein histidine kinase activity
IPMB12_10465	COG0745	RESPONSE REGULATOR receiver
IPMB12_10470	COG0402	S-adenosylhomocysteine deaminase activity
IPMB12_10500	COG1408	metallophosphoesterase
IPMB12_10505	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IPMB12_10520	COG5339	Protein conserved in bacteria
IPMB12_10525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IPMB12_10530	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPMB12_10540	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPMB12_10550	COG1733	regulation of RNA biosynthetic process
IPMB12_10555	COG2910	NAD(P)H-binding
IPMB12_10560	COG1757	Na H antiporter
IPMB12_10585	COG1643	Atp-dependent helicase
IPMB12_10590	COG3187	Heat shock protein
IPMB12_10600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPMB12_10625	COG1187	pseudouridine synthase activity
IPMB12_10630	COG0009	L-threonylcarbamoyladenylate synthase
IPMB12_10635	COG0613	PHP domain protein
IPMB12_10640	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IPMB12_10650	COG2890	protein-(glutamine-N5) methyltransferase activity
IPMB12_10655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPMB12_10660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IPMB12_10665	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IPMB12_10670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPMB12_10680	COG4948	Mandelate Racemase Muconate Lactonizing
IPMB12_10685	COG2271	Major facilitator Superfamily
IPMB12_10695	COG2925	Exonuclease
IPMB12_10700	COG1380	Effector of murein hydrolase LrgA
IPMB12_10705	COG1346	cytolysis
IPMB12_10710	COG2949	membrane
IPMB12_10715	COG1126	abc transporter atp-binding protein
IPMB12_10720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPMB12_10725	COG4215	(ABC) transporter
IPMB12_10730	COG4160	amino acid transport
IPMB12_10735	COG0322	excinuclease ABC activity
IPMB12_10755	COG0582	viral genome integration into host DNA
IPMB12_10810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPMB12_10860	COG3209	COG3209 Rhs family protein
IPMB12_11075	COG0667	Aldo Keto reductase
IPMB12_11080	COG0582	viral genome integration into host DNA
IPMB12_11085	COG2003	Belongs to the UPF0758 family
IPMB12_11170	COG0406	alpha-ribazole phosphatase activity
IPMB12_11190	COG3716	PTS system mannose fructose sorbose family IID component
IPMB12_11200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPMB12_11205	COG0800	Aldolase
IPMB12_11215	COG0129	dihydroxy-acid dehydratase activity
IPMB12_11220	COG1609	Transcriptional regulator
IPMB12_11230	COG1064	alcohol dehydrogenase
IPMB12_11245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPMB12_11250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPMB12_11255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPMB12_11265	COG0196	riboflavin kinase activity
IPMB12_11270	COG2259	Doxx family
IPMB12_11275	COG0583	DNA-binding transcription factor activity
IPMB12_11280	COG0302	gtp cyclohydrolase
IPMB12_11285	COG0531	amino acid
IPMB12_11290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPMB12_11290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPMB12_11295	COG0805	protein transport
IPMB12_11300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPMB12_11305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPMB12_11310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPMB12_11335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPMB12_11340	COG2731	YhcH YjgK YiaL family protein
IPMB12_11345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPMB12_11360	COG1704	LemA family
IPMB12_11365	COG2848	UPF0210 protein
IPMB12_11370	COG3830	Belongs to the UPF0237 family
IPMB12_11375	COG0436	Aminotransferase
IPMB12_11385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPMB12_11390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPMB12_11395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IPMB12_11405	COG0656	L-ascorbic acid biosynthetic process
IPMB12_11415	COG0697	spore germination
IPMB12_11420	COG5006	permease, DMT superfamily
IPMB12_11430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPMB12_11440	COG0195	Participates in both transcription termination and antitermination
IPMB12_11460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPMB12_11480	COG5007	Belongs to the BolA IbaG family
IPMB12_11490	COG2854	intermembrane phospholipid transfer
IPMB12_11495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IPMB12_11500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPMB12_11505	COG1127	ABC transporter
IPMB12_11515	COG0308	aminopeptidase N
IPMB12_11530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IPMB12_11535	COG1803	Methylglyoxal synthase
IPMB12_11540	COG0477	Major facilitator Superfamily
IPMB12_11545	COG0121	glutamine amidotransferase
IPMB12_11550	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IPMB12_11555	COG0387	Pfam Sodium calcium exchanger
IPMB12_11570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IPMB12_11580	COG3423	Transcriptional regulator
IPMB12_11595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IPMB12_11600	COG1519	Transferase
IPMB12_11605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IPMB12_11610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPMB12_11620	COG5492	domain, Protein
IPMB12_11630	COG1418	mRNA catabolic process
IPMB12_11640	COG2217	Heavy metal translocating P-type atpase
IPMB12_11650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPMB12_11660	COG2818	Glycosylase
IPMB12_11665	COG0752	glycyl-tRNA synthetase alpha subunit
IPMB12_11670	COG0751	glycine-tRNA ligase activity
IPMB12_11680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IPMB12_11685	COG2271	Major facilitator Superfamily
IPMB12_11690	COG1070	Carbohydrate kinase
IPMB12_11700	COG1830	Aldolase
IPMB12_11705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPMB12_11710	COG1560	Kdo2-lipid A biosynthetic process
IPMB12_11715	COG0243	molybdopterin cofactor binding
IPMB12_11715	COG3383	formate dehydrogenase (NAD+) activity
IPMB12_11720	COG0437	4 iron, 4 sulfur cluster binding
IPMB12_11725	COG2864	formate dehydrogenase
IPMB12_11730	COG3058	Necessary for formate dehydrogenase activity
IPMB12_11770	COG1122	ATPase activity
IPMB12_11780	COG2982	Protein involved in outer membrane biogenesis
IPMB12_11785	COG0717	Belongs to the dCTP deaminase family
IPMB12_11805	COG0489	protein tyrosine kinase activity
IPMB12_11810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPMB12_11810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPMB12_11830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IPMB12_11835	COG0402	S-adenosylhomocysteine deaminase activity
IPMB12_11845	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPMB12_11850	COG0477	Major facilitator Superfamily
IPMB12_11855	COG1115	amino acid carrier protein
IPMB12_11860	COG0577	efflux transmembrane transporter activity
IPMB12_11860	COG1136	(ABC) transporter
IPMB12_11865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPMB12_11875	COG3117	lipopolysaccharide transmembrane transporter activity
IPMB12_11885	COG1137	ATPase activity
IPMB12_11890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IPMB12_11900	COG1242	4 iron, 4 sulfur cluster binding
IPMB12_11905	COG2974	May be involved in recombination
IPMB12_11940	COG0629	single-stranded DNA binding
IPMB12_11955	COG3846	protein secretion by the type IV secretion system
IPMB12_11975	COG3504	Conjugal transfer protein
IPMB12_11985	COG3451	type IV secretory pathway VirB4
IPMB12_11990	COG5268	conjugation
IPMB12_12025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone