locus-tag	class	description
ZPR_0002	COG0481	GTPase activity
ZPR_0003	COG0217	transcriptional regulatory protein
ZPR_0004	COG3263	regulation of cellular component size
ZPR_0005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_0008	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_0009	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_0010	COG0594	ribonuclease P activity
ZPR_0011	COG0793	Belongs to the peptidase S41A family
ZPR_0012	COG2153	protein acetylation
ZPR_0013	COG0698	ribose 5-phosphate isomerase
ZPR_0016	COG0557	exoribonuclease II activity
ZPR_0022	COG0531	amino acid
ZPR_0023	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZPR_0027	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZPR_0029	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZPR_0030	COG0445	tRNA wobble uridine modification
ZPR_0035	COG0470	DNA polymerase III
ZPR_0036	COG0126	phosphoglycerate kinase activity
ZPR_0037	COG3942	CHAP domain
ZPR_0037	COG1388	LysM domain
ZPR_0039	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZPR_0043	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_0044	COG1215	transferase activity, transferring glycosyl groups
ZPR_0046	COG0151	Belongs to the GarS family
ZPR_0051	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ZPR_0061	COG0356	it plays a direct role in the translocation of protons across the membrane
ZPR_0062	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZPR_0063	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZPR_0064	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZPR_0065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZPR_0066	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZPR_0069	COG0756	dUTP diphosphatase activity
ZPR_0076	COG1607	acyl-coa hydrolase
ZPR_0078	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZPR_0078	COG0758	DNA mediated transformation
ZPR_0079	COG0180	Tryptophanyl-tRNA synthetase
ZPR_0086	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZPR_0087	COG0826	peptidase U32
ZPR_0090	COG1774	PSP1 C-terminal conserved region
ZPR_0092	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZPR_0093	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ZPR_0098	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_0098	COG1506	peptidase
ZPR_0101	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZPR_0105	COG0113	porphobilinogen synthase activity
ZPR_0107	COG0408	coproporphyrinogen oxidase activity
ZPR_0110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZPR_0112	COG0181	hydroxymethylbilane synthase activity
ZPR_0113	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ZPR_0116	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZPR_0120	COG1024	Enoyl-CoA hydratase
ZPR_0125	COG1418	mRNA catabolic process
ZPR_0128	COG0484	heat shock protein binding
ZPR_0132	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_0135	COG0720	synthase
ZPR_0137	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZPR_0139	COG0352	thiamine-phosphate diphosphorylase activity
ZPR_0140	COG2022	thiamine diphosphate biosynthetic process
ZPR_0141	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZPR_0143	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZPR_0144	COG0024	Methionine aminopeptidase
ZPR_0145	COG1621	beta-fructofuranosidase activity
ZPR_0156	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ZPR_0157	COG1335	isochorismatase
ZPR_0161	COG1381	Involved in DNA repair and RecF pathway recombination
ZPR_0175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZPR_0178	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZPR_0180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ZPR_0182	COG0189	ligase activity
ZPR_0184	COG0322	excinuclease ABC activity
ZPR_0185	COG1752	Esterase of the alpha-beta hydrolase superfamily
ZPR_0188	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZPR_0189	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ZPR_0190	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ZPR_0192	COG3483	tryptophan 2,3-dioxygenase activity
ZPR_0194	COG0166	Belongs to the GPI family
ZPR_0197	COG2356	endonuclease I
ZPR_0205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZPR_0208	COG2151	metal-sulfur cluster biosynthetic enzyme
ZPR_0209	COG2166	iron-sulfur cluster assembly
ZPR_0211	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZPR_0212	COG0719	Fe-S assembly protein
ZPR_0213	COG0396	ATPase activity
ZPR_0215	COG0719	Fe-S assembly protein
ZPR_0217	COG0316	Belongs to the HesB IscA family
ZPR_0218	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZPR_0223	COG4206	TonB-dependent receptor
ZPR_0223	COG1629	transport
ZPR_0227	COG0006	proline dipeptidase activity
ZPR_0228	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_0229	COG0367	asparagine synthase
ZPR_0231	COG1053	succinate dehydrogenase
ZPR_0232	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ZPR_0236	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZPR_0236	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZPR_0240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZPR_0240	COG1321	iron dependent repressor
ZPR_0248	COG1999	signal sequence binding
ZPR_0249	COG0750	zinc metalloprotease
ZPR_0250	COG0584	glycerophosphoryl diester phosphodiesterase
ZPR_0253	COG1629	transport
ZPR_0253	COG4206	TonB-dependent receptor
ZPR_0263	COG0534	Mate efflux family protein
ZPR_0271	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_0272	COG1074	ATP-dependent DNA helicase activity
ZPR_0274	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZPR_0276	COG0328	RNA-DNA hybrid ribonuclease activity
ZPR_0278	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZPR_0279	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZPR_0280	COG0571	ribonuclease III activity
ZPR_0282	COG0469	pyruvate kinase activity
ZPR_0283	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZPR_0284	COG0702	epimerase
ZPR_0289	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ZPR_0291	COG1538	Outer membrane efflux protein
ZPR_0293	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_0296	COG1446	asparaginase
ZPR_0297	COG0662	Cupin 2, conserved barrel domain protein
ZPR_0299	COG0653	protein targeting
ZPR_0302	COG3279	Response regulator of the LytR AlgR family
ZPR_0306	COG2824	Alkylphosphonate utilization operon protein PhnA
ZPR_0307	COG0793	Belongs to the peptidase S41A family
ZPR_0308	COG3339	Conserved Protein
ZPR_0312	COG4221	oxidoreductase activity
ZPR_0315	COG0714	Associated with various cellular activities
ZPR_0318	COG2304	oxidoreductase activity
ZPR_0323	COG0288	reversible hydration of carbon dioxide
ZPR_0328	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZPR_0332	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZPR_0333	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZPR_0334	COG0194	GDP metabolic process
ZPR_0335	COG1561	YicC-like family, N-terminal region
ZPR_0336	COG0429	hydrolase of the alpha beta-hydrolase fold
ZPR_0341	COG0626	cystathionine gamma-synthase activity
ZPR_0344	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZPR_0351	COG4206	TonB-dependent receptor
ZPR_0351	COG1629	transport
ZPR_0354	COG4124	Belongs to the glycosyl hydrolase 26 family
ZPR_0357	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ZPR_0358	COG2942	2-epimerase
ZPR_0359	COG2272	Belongs to the type-B carboxylesterase lipase family
ZPR_0361	COG2382	esterase
ZPR_0361	COG3693	PFAM glycoside hydrolase, family 10
ZPR_0362	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZPR_0364	COG0471	metal ion transport
ZPR_0379	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_0380	COG1595	DNA-templated transcription, initiation
ZPR_0384	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_0387	COG0612	Peptidase, M16
ZPR_0390	COG4206	TonB-dependent receptor
ZPR_0390	COG1629	transport
ZPR_0392	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_0398	COG3720	iron ion transport
ZPR_0399	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZPR_0400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZPR_0402	COG4206	TonB-dependent receptor
ZPR_0412	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZPR_0414	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZPR_0416	COG2095	MarC family integral membrane protein
ZPR_0420	COG0793	Belongs to the peptidase S41A family
ZPR_0426	COG4585	Histidine kinase
ZPR_0427	COG2197	response regulator
ZPR_0443	COG1629	transport
ZPR_0443	COG4206	TonB-dependent receptor
ZPR_0446	COG0477	Major facilitator Superfamily
ZPR_0448	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZPR_0449	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZPR_0450	COG0193	aminoacyl-tRNA hydrolase activity
ZPR_0451	COG0196	riboflavin kinase activity
ZPR_0453	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZPR_0457	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZPR_0458	COG2239	Acts as a magnesium transporter
ZPR_0459	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_0462	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZPR_0463	COG0702	epimerase
ZPR_0465	COG0527	aspartate kinase activity
ZPR_0468	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ZPR_0472	COG1793	dna ligase
ZPR_0474	COG1201	RNA secondary structure unwinding
ZPR_0476	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZPR_0481	COG0423	glycine-tRNA ligase activity
ZPR_0482	COG1528	Iron-storage protein
ZPR_0484	COG1522	sequence-specific DNA binding
ZPR_0486	COG2363	Small membrane protein
ZPR_0487	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZPR_0490	COG0463	Glycosyl transferase, family 2
ZPR_0491	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZPR_0494	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZPR_0499	COG0745	RESPONSE REGULATOR receiver
ZPR_0500	COG5002	protein histidine kinase activity
ZPR_0502	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZPR_0505	COG0489	protein tyrosine kinase activity
ZPR_0507	COG0492	ferredoxin-NADP+ reductase activity
ZPR_0511	COG1960	acyl-CoA dehydrogenase activity
ZPR_0512	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ZPR_0513	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZPR_0514	COG0052	Belongs to the universal ribosomal protein uS2 family
ZPR_0515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZPR_0516	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZPR_0517	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZPR_0517	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZPR_0519	COG1446	asparaginase
ZPR_0522	COG0726	polysaccharide deacetylase
ZPR_0525	COG3273	potassium ion transport
ZPR_0525	COG0471	metal ion transport
ZPR_0527	COG4206	TonB-dependent receptor
ZPR_0527	COG1629	transport
ZPR_0529	COG0612	Peptidase, M16
ZPR_0538	COG0662	Cupin 2, conserved barrel domain protein
ZPR_0538	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ZPR_0539	COG0529	Catalyzes the synthesis of activated sulfate
ZPR_0540	COG0175	sulfate reduction
ZPR_0542	COG1218	3'(2'),5'-bisphosphate nucleotidase
ZPR_0543	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZPR_0544	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_0545	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ZPR_0553	COG0438	transferase activity, transferring glycosyl groups
ZPR_0557	COG0438	transferase activity, transferring glycosyl groups
ZPR_0561	COG0463	Glycosyl transferase, family 2
ZPR_0562	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_0573	COG0779	Required for maturation of 30S ribosomal subunits
ZPR_0574	COG0195	Participates in both transcription termination and antitermination
ZPR_0574	COG2251	uridine kinase activity
ZPR_0575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZPR_0578	COG0437	4 iron, 4 sulfur cluster binding
ZPR_0579	COG0052	Belongs to the universal ribosomal protein uS2 family
ZPR_0584	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ZPR_0585	COG2255	four-way junction helicase activity
ZPR_0586	COG2124	cytochrome p450
ZPR_0587	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZPR_0588	COG0281	malic enzyme
ZPR_0588	COG0280	phosphate acetyltransferase
ZPR_0589	COG0632	four-way junction helicase activity
ZPR_0591	COG0509	glycine decarboxylation via glycine cleavage system
ZPR_0595	COG0109	protoheme IX farnesyltransferase activity
ZPR_0596	COG1845	cytochrome c oxidase, subunit III
ZPR_0597	COG1845	cytochrome c oxidase, subunit III
ZPR_0600	COG1999	signal sequence binding
ZPR_0601	COG2322	membrane
ZPR_0603	COG1136	(ABC) transporter
ZPR_0604	COG1136	(ABC) transporter
ZPR_0604	COG0577	efflux transmembrane transporter activity
ZPR_0605	COG0577	efflux transmembrane transporter activity
ZPR_0605	COG1136	(ABC) transporter
ZPR_0606	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_0609	COG1214	PFAM Peptidase M22, glycoprotease
ZPR_0610	COG0668	transmembrane transport
ZPR_0611	COG1331	Highly conserved protein containing a thioredoxin domain
ZPR_0615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZPR_0618	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZPR_0621	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZPR_0623	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZPR_0624	COG0596	Alpha beta hydrolase
ZPR_0627	COG1950	PFAM Membrane protein of
ZPR_0628	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZPR_0630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZPR_0632	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_0632	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_0633	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_0634	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZPR_0635	COG0587	DNA-directed DNA polymerase activity
ZPR_0638	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZPR_0640	COG0457	Tetratricopeptide repeat
ZPR_0643	COG1253	flavin adenine dinucleotide binding
ZPR_0644	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZPR_0647	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_0647	COG1506	peptidase
ZPR_0648	COG3104	oligopeptide transport
ZPR_0650	COG2333	competence protein COMEC
ZPR_0650	COG0658	competence protein
ZPR_0653	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_0655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZPR_0657	COG0772	Belongs to the SEDS family
ZPR_0658	COG0768	penicillin binding
ZPR_0661	COG1077	Cell shape determining protein MreB Mrl
ZPR_0662	COG0138	bifunctional purine biosynthesis protein purh
ZPR_0668	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_0673	COG4977	sequence-specific DNA binding
ZPR_0673	COG1917	Cupin 2, conserved barrel domain protein
ZPR_0675	COG2217	Heavy metal translocating P-type atpase
ZPR_0676	COG0701	Predicted permease
ZPR_0679	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ZPR_0680	COG0321	lipoyl(octanoyl) transferase activity
ZPR_0681	COG1629	transport
ZPR_0681	COG4206	TonB-dependent receptor
ZPR_0683	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZPR_0684	COG1629	transport
ZPR_0684	COG4206	TonB-dependent receptor
ZPR_0687	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZPR_0688	COG1629	transport
ZPR_0688	COG4206	TonB-dependent receptor
ZPR_0690	COG1629	transport
ZPR_0690	COG4206	TonB-dependent receptor
ZPR_0691	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZPR_0701	COG4206	TonB-dependent receptor
ZPR_0701	COG1629	transport
ZPR_0713	COG0702	epimerase
ZPR_0714	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZPR_0727	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZPR_0734	COG4115	mRNA cleavage
ZPR_0741	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZPR_0746	COG0456	acetyltransferase
ZPR_0747	COG1846	Transcriptional regulator
ZPR_0748	COG4206	TonB-dependent receptor
ZPR_0748	COG1629	transport
ZPR_0750	COG4206	TonB-dependent receptor
ZPR_0750	COG1629	transport
ZPR_0755	COG4191	Histidine kinase
ZPR_0755	COG2205	protein histidine kinase activity
ZPR_0755	COG0745	RESPONSE REGULATOR receiver
ZPR_0759	COG0798	PFAM Bile acid sodium symporter
ZPR_0764	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ZPR_0765	COG1349	DNA-binding transcription factor activity
ZPR_0768	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ZPR_0771	COG0386	Belongs to the glutathione peroxidase family
ZPR_0772	COG1846	Transcriptional regulator
ZPR_0777	COG0659	secondary active sulfate transmembrane transporter activity
ZPR_0778	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZPR_0780	COG1160	GTP binding
ZPR_0786	COG0739	heme binding
ZPR_0787	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZPR_0791	COG3186	Phenylalanine-4-hydroxylase
ZPR_0793	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ZPR_0795	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ZPR_0797	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ZPR_0801	COG0110	maltose O-acetyltransferase activity
ZPR_0805	COG0688	phosphatidylethanolamine metabolic process
ZPR_0806	COG4589	Belongs to the CDS family
ZPR_0808	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZPR_0809	COG0799	negative regulation of ribosome biogenesis
ZPR_0810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ZPR_0810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ZPR_0812	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZPR_0813	COG1051	belongs to the nudix hydrolase family
ZPR_0818	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZPR_0820	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZPR_0822	COG0564	pseudouridine synthase activity
ZPR_0823	COG3022	response to hydroperoxide
ZPR_0829	COG0159	tryptophan synthase activity
ZPR_0830	COG0133	tryptophan synthase activity
ZPR_0831	COG0135	phosphoribosylanthranilate isomerase activity
ZPR_0832	COG0134	indole-3-glycerol-phosphate synthase activity
ZPR_0833	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZPR_0834	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZPR_0834	COG0512	Glutamine amidotransferase of anthranilate synthase
ZPR_0835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZPR_0836	COG2353	YceI-like domain
ZPR_0837	COG0778	Nitroreductase
ZPR_0839	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZPR_0841	COG2884	Cell division ATP-binding protein ftsE
ZPR_0845	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ZPR_0846	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZPR_0847	COG0450	alkyl hydroperoxide reductase
ZPR_0849	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZPR_0850	COG0569	domain protein
ZPR_0851	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZPR_0854	COG1132	(ABC) transporter
ZPR_0856	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZPR_0858	COG1862	Preprotein translocase
ZPR_0860	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZPR_0861	COG0167	dihydroorotate dehydrogenase activity
ZPR_0865	COG0516	GMP reductase activity
ZPR_0865	COG0517	IMP dehydrogenase activity
ZPR_0868	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZPR_0869	COG0714	Associated with various cellular activities
ZPR_0870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZPR_0872	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_0876	COG1233	COG1233 Phytoene dehydrogenase and related
ZPR_0887	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZPR_0888	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ZPR_0889	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ZPR_0892	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZPR_0893	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ZPR_0894	COG0343	queuine tRNA-ribosyltransferase activity
ZPR_0896	COG0825	malonyl-CoA metabolic process
ZPR_0897	COG0305	Participates in initiation and elongation during chromosome replication
ZPR_0899	COG0432	Pfam Uncharacterised protein family UPF0047
ZPR_0904	COG4206	TonB-dependent receptor
ZPR_0904	COG1629	transport
ZPR_0905	COG4206	TonB-dependent receptor
ZPR_0905	COG1629	transport
ZPR_0907	COG1629	transport
ZPR_0907	COG4206	TonB-dependent receptor
ZPR_0911	COG3250	beta-galactosidase activity
ZPR_0919	COG2814	Major facilitator Superfamily
ZPR_0922	COG0492	ferredoxin-NADP+ reductase activity
ZPR_0923	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZPR_0924	COG0095	Lipoate-protein ligase
ZPR_0926	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZPR_0928	COG1185	polyribonucleotide nucleotidyltransferase activity
ZPR_0930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZPR_0931	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZPR_0932	COG0191	fructose-bisphosphate aldolase activity
ZPR_0934	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZPR_0936	COG2226	methyltransferase
ZPR_0937	COG0569	domain protein
ZPR_0938	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZPR_0940	COG3239	Fatty acid desaturase
ZPR_0941	COG0357	Ribosomal RNA small subunit methyltransferase G
ZPR_0943	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_0948	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_0949	COG1805	sodium ion transport
ZPR_0950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_0951	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_0952	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_0955	COG1477	protein flavinylation
ZPR_0956	COG2226	methyltransferase
ZPR_0961	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ZPR_0964	COG0740	serine-type endopeptidase activity
ZPR_0968	COG5002	protein histidine kinase activity
ZPR_0969	COG0745	RESPONSE REGULATOR receiver
ZPR_0974	COG0101	tRNA pseudouridine synthase activity
ZPR_0975	COG1132	(ABC) transporter
ZPR_0978	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ZPR_0979	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZPR_0982	COG0149	triose-phosphate isomerase activity
ZPR_0983	COG2264	protein methyltransferase activity
ZPR_0990	COG0629	single-stranded DNA binding
ZPR_0994	COG2197	response regulator
ZPR_1008	COG3250	beta-galactosidase activity
ZPR_1012	COG4145	pantothenate transmembrane transporter activity
ZPR_1014	COG2186	Transcriptional regulator
ZPR_1016	COG4206	TonB-dependent receptor
ZPR_1016	COG1629	transport
ZPR_1020	COG4206	TonB-dependent receptor
ZPR_1020	COG1629	transport
ZPR_1023	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_1024	COG2382	esterase
ZPR_1025	COG3693	PFAM glycoside hydrolase, family 10
ZPR_1025	COG2382	esterase
ZPR_1026	COG2382	esterase
ZPR_1028	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_1030	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_1031	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_1033	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_1043	COG2354	Protein conserved in bacteria
ZPR_1045	COG0745	RESPONSE REGULATOR receiver
ZPR_1053	COG2318	DinB family
ZPR_1056	COG0584	glycerophosphoryl diester phosphodiesterase
ZPR_1057	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ZPR_1059	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZPR_1062	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZPR_1064	COG1917	Cupin 2, conserved barrel domain protein
ZPR_1064	COG2169	Transcriptional regulator
ZPR_1069	COG2267	carboxylic ester hydrolase activity
ZPR_1071	COG3952	Lipid A Biosynthesis
ZPR_1071	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_1073	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_1074	COG1703	isobutyryl-CoA mutase activity
ZPR_1075	COG1764	response to oxidative stress
ZPR_1082	COG0653	protein targeting
ZPR_1086	COG1136	(ABC) transporter
ZPR_1090	COG0488	(ABC) transporter
ZPR_1100	COG1215	transferase activity, transferring glycosyl groups
ZPR_1101	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ZPR_1112	COG0367	asparagine synthase
ZPR_1113	COG1083	cytidylyl-transferase
ZPR_1114	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZPR_1117	COG2089	acid synthase
ZPR_1118	COG1216	Glycosyl transferase, family 2
ZPR_1120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZPR_1124	COG0438	transferase activity, transferring glycosyl groups
ZPR_1126	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ZPR_1128	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZPR_1131	COG1137	ATPase activity
ZPR_1133	COG0805	protein transport
ZPR_1134	COG0517	IMP dehydrogenase activity
ZPR_1134	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZPR_1135	COG0514	ATP-dependent DNA helicase (RecQ)
ZPR_1141	COG3876	Protein conserved in bacteria
ZPR_1142	COG0577	efflux transmembrane transporter activity
ZPR_1145	COG1115	amino acid carrier protein
ZPR_1150	COG1115	amino acid carrier protein
ZPR_1152	COG1960	acyl-CoA dehydrogenase activity
ZPR_1153	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZPR_1154	COG4974	Belongs to the 'phage' integrase family
ZPR_1160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZPR_1164	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZPR_1165	COG0081	regulation of translation
ZPR_1166	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZPR_1167	COG0222	ribosome binding
ZPR_1168	COG0085	RNA polymerase activity
ZPR_1169	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZPR_1171	COG0248	Ppx GppA phosphatase
ZPR_1172	COG1115	amino acid carrier protein
ZPR_1173	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZPR_1174	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ZPR_1178	COG0579	oxidoreductase
ZPR_1181	COG0561	phosphatase activity
ZPR_1183	COG1073	alpha beta
ZPR_1189	COG0784	Response regulator, receiver
ZPR_1189	COG2205	protein histidine kinase activity
ZPR_1191	COG0326	Molecular chaperone. Has ATPase activity
ZPR_1194	COG1506	peptidase
ZPR_1195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZPR_1196	COG3385	transposase activity
ZPR_1202	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ZPR_1212	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ZPR_1214	COG0009	L-threonylcarbamoyladenylate synthase
ZPR_1215	COG0542	response to heat
ZPR_1219	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZPR_1226	COG0300	oxidoreductase activity
ZPR_1227	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ZPR_1229	COG0488	(ABC) transporter
ZPR_1233	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZPR_1235	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_1236	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZPR_1240	COG1546	Belongs to the CinA family
ZPR_1240	COG1058	Belongs to the CinA family
ZPR_1241	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZPR_1242	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZPR_1244	COG0552	protein localization to endoplasmic reticulum
ZPR_1245	COG0154	amidase activity
ZPR_1253	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZPR_1260	COG0656	L-ascorbic acid biosynthetic process
ZPR_1261	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_1263	COG4974	Belongs to the 'phage' integrase family
ZPR_1282	COG0612	Peptidase, M16
ZPR_1284	COG1629	transport
ZPR_1284	COG4206	TonB-dependent receptor
ZPR_1290	COG4974	Belongs to the 'phage' integrase family
ZPR_1296	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZPR_1310	COG0517	IMP dehydrogenase activity
ZPR_1311	COG4584	PFAM Integrase catalytic
ZPR_1312	COG1484	DNA-dependent DNA replication
ZPR_1321	COG3328	transposase activity
ZPR_1346	COG4977	sequence-specific DNA binding
ZPR_1346	COG1917	Cupin 2, conserved barrel domain protein
ZPR_1347	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_1352	COG2985	domain, Protein
ZPR_1352	COG0490	domain, Protein
ZPR_1355	COG0589	response to stress
ZPR_1356	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZPR_1359	COG1053	succinate dehydrogenase
ZPR_1360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ZPR_1362	COG4221	oxidoreductase activity
ZPR_1363	COG0569	domain protein
ZPR_1364	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZPR_1367	COG2205	protein histidine kinase activity
ZPR_1369	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZPR_1370	COG0666	response to abiotic stimulus
ZPR_1371	COG3047	cAMP biosynthetic process
ZPR_1376	COG3534	alpha-L-arabinofuranosidase
ZPR_1379	COG1506	peptidase
ZPR_1379	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_1380	COG0561	phosphatase activity
ZPR_1381	COG1629	transport
ZPR_1381	COG4206	TonB-dependent receptor
ZPR_1382	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZPR_1383	COG3938	Belongs to the proline racemase family
ZPR_1385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZPR_1386	COG2207	Transcriptional regulator
ZPR_1388	COG3250	beta-galactosidase activity
ZPR_1389	COG0006	proline dipeptidase activity
ZPR_1394	COG2311	Membrane
ZPR_1402	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ZPR_1403	COG1845	cytochrome c oxidase, subunit III
ZPR_1407	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZPR_1408	COG0069	glutamate synthase activity
ZPR_1428	COG0598	Magnesium transport protein CorA
ZPR_1431	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_1443	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ZPR_1454	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_1456	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZPR_1458	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZPR_1463	COG0681	Belongs to the peptidase S26 family
ZPR_1464	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZPR_1466	COG1475	DNA binding
ZPR_1467	COG1192	Involved in chromosome partitioning
ZPR_1468	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_1469	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_1469	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_1470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_1472	COG0572	uridine kinase
ZPR_1473	COG2010	Cytochrome c
ZPR_1474	COG2133	pyrroloquinoline quinone binding
ZPR_1478	COG0745	RESPONSE REGULATOR receiver
ZPR_1479	COG5002	protein histidine kinase activity
ZPR_1482	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZPR_1492	COG3239	Fatty acid desaturase
ZPR_1496	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZPR_1518	COG4584	PFAM Integrase catalytic
ZPR_1521	COG2801	Transposase and inactivated derivatives
ZPR_1541	COG3250	beta-galactosidase activity
ZPR_1545	COG0657	acetylesterase activity
ZPR_1545	COG2755	lipolytic protein G-D-S-L family
ZPR_1547	COG1629	transport
ZPR_1547	COG4206	TonB-dependent receptor
ZPR_1548	COG1609	Transcriptional regulator
ZPR_1549	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_1549	COG3347	Dehydrogenase
ZPR_1550	COG4952	isomerase
ZPR_1552	COG1304	FMN binding
ZPR_1554	COG1629	transport
ZPR_1554	COG4206	TonB-dependent receptor
ZPR_1561	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_1565	COG1673	EVE domain
ZPR_1570	COG4771	TonB-dependent receptor
ZPR_1582	COG1858	cytochrome C peroxidase
ZPR_1588	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_1590	COG0386	Belongs to the glutathione peroxidase family
ZPR_1605	COG3119	arylsulfatase activity
ZPR_1607	COG4771	TonB-dependent receptor
ZPR_1615	COG3851	Histidine kinase
ZPR_1629	COG1629	transport
ZPR_1629	COG4206	TonB-dependent receptor
ZPR_1640	COG0494	nUDIX hydrolase
ZPR_1642	COG0516	GMP reductase activity
ZPR_1643	COG0019	diaminopimelate decarboxylase activity
ZPR_1644	COG2814	Major facilitator Superfamily
ZPR_1645	COG0045	succinate-CoA ligase (ADP-forming) activity
ZPR_1647	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ZPR_1654	COG1228	amidohydrolase
ZPR_1656	COG1064	alcohol dehydrogenase
ZPR_1657	COG0028	Belongs to the TPP enzyme family
ZPR_1658	COG0626	cystathionine gamma-synthase activity
ZPR_1659	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ZPR_1663	COG3956	TIGRFAM MazG family protein
ZPR_1664	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZPR_1666	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZPR_1670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZPR_1674	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZPR_1676	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ZPR_1678	COG0501	Belongs to the peptidase M48B family
ZPR_1679	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZPR_1681	COG1228	amidohydrolase
ZPR_1684	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZPR_1686	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZPR_1688	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ZPR_1690	COG0105	UTP biosynthetic process
ZPR_1691	COG0473	3-isopropylmalate dehydrogenase activity
ZPR_1692	COG0066	3-isopropylmalate dehydratase activity
ZPR_1693	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZPR_1694	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZPR_1697	COG3387	PFAM Glycoside hydrolase 15-related
ZPR_1698	COG3387	PFAM Glycoside hydrolase 15-related
ZPR_1699	COG0564	pseudouridine synthase activity
ZPR_1701	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ZPR_1707	COG1760	l-serine dehydratase
ZPR_1708	COG0443	Heat shock 70 kDa protein
ZPR_1715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ZPR_1718	COG2996	Protein conserved in bacteria
ZPR_1730	COG0022	dehydrogenase e1 component
ZPR_1732	COG1611	Belongs to the LOG family
ZPR_1733	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZPR_1735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZPR_1740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_1744	COG1994	Peptidase M50
ZPR_1748	COG1921	L-seryl-tRNASec selenium transferase activity
ZPR_1749	COG0251	oxidation-reduction process
ZPR_1751	COG4206	TonB-dependent receptor
ZPR_1751	COG1629	transport
ZPR_1757	COG1475	DNA binding
ZPR_1759	COG0629	single-stranded DNA binding
ZPR_1776	COG1388	LysM domain
ZPR_1776	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZPR_1784	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZPR_1794	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZPR_1794	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_1796	COG0450	alkyl hydroperoxide reductase
ZPR_1803	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_1804	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_1810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_1811	COG0783	Belongs to the Dps family
ZPR_1812	COG0783	Belongs to the Dps family
ZPR_1814	COG0737	Belongs to the 5'-nucleotidase family
ZPR_1817	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_1818	COG0737	Belongs to the 5'-nucleotidase family
ZPR_1828	COG4974	Belongs to the 'phage' integrase family
ZPR_1829	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZPR_1831	COG0592	DNA-directed DNA polymerase activity
ZPR_1836	COG1702	phosphate starvation-inducible protein PhoH
ZPR_1837	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZPR_1838	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ZPR_1842	COG1363	Peptidase, m42
ZPR_1851	COG0116	Belongs to the methyltransferase superfamily
ZPR_1855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZPR_1856	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZPR_1863	COG1104	cysteine desulfurase activity
ZPR_1867	COG1418	mRNA catabolic process
ZPR_1868	COG0656	L-ascorbic acid biosynthetic process
ZPR_1869	COG4974	Belongs to the 'phage' integrase family
ZPR_1872	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZPR_1874	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_1876	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZPR_1877	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZPR_1880	COG2270	Major facilitator Superfamily
ZPR_1884	COG1595	DNA-templated transcription, initiation
ZPR_1885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ZPR_1886	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZPR_1887	COG2814	Major facilitator Superfamily
ZPR_1889	COG0539	negative regulation of cytoplasmic translation
ZPR_1896	COG0346	lactoylglutathione lyase activity
ZPR_1897	COG4302	ethanolamine ammonia-lyase activity
ZPR_1898	COG4303	Ethanolamine ammonia lyase large subunit
ZPR_1899	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ZPR_1900	COG1764	response to oxidative stress
ZPR_1901	COG1846	Transcriptional regulator
ZPR_1903	COG0590	tRNA wobble adenosine to inosine editing
ZPR_1905	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ZPR_1906	COG0540	Belongs to the ATCase OTCase family
ZPR_1908	COG1234	tRNA 3'-trailer cleavage
ZPR_1909	COG0259	pyridoxamine-phosphate oxidase activity
ZPR_1911	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZPR_1912	COG0248	Ppx GppA phosphatase
ZPR_1914	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZPR_1915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZPR_1917	COG0745	RESPONSE REGULATOR receiver
ZPR_1918	COG0642	Histidine kinase
ZPR_1920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_1921	COG1477	protein flavinylation
ZPR_1936	COG4181	ATPase activity
ZPR_1944	COG0312	modulator of DNA gyrase
ZPR_1945	COG0312	modulator of DNA gyrase
ZPR_1947	COG0714	Associated with various cellular activities
ZPR_1954	COG3279	Response regulator of the LytR AlgR family
ZPR_1960	COG1538	Outer membrane efflux protein
ZPR_1963	COG1629	transport
ZPR_1963	COG4206	TonB-dependent receptor
ZPR_1965	COG1785	Belongs to the alkaline phosphatase family
ZPR_1966	COG1785	Belongs to the alkaline phosphatase family
ZPR_1973	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ZPR_1974	COG0351	phosphomethylpyrimidine kinase
ZPR_1975	COG0352	thiamine-phosphate diphosphorylase activity
ZPR_1976	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ZPR_1979	COG1733	regulation of RNA biosynthetic process
ZPR_1984	COG0730	response to heat
ZPR_1985	COG1271	oxidase subunit
ZPR_1987	COG3940	Belongs to the glycosyl hydrolase 43 family
ZPR_1988	COG1476	TRANSCRIPTIONal
ZPR_1998	COG0439	Biotin carboxylase
ZPR_1999	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ZPR_2000	COG0107	imidazoleglycerol-phosphate synthase activity
ZPR_2001	COG0140	phosphoribosyl-ATP diphosphatase activity
ZPR_2001	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZPR_2003	COG1741	Belongs to the pirin family
ZPR_2005	COG1942	4-Oxalocrotonate Tautomerase
ZPR_2006	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ZPR_2009	COG0514	ATP-dependent DNA helicase (RecQ)
ZPR_2010	COG0598	Magnesium transport protein CorA
ZPR_2011	COG2706	6-phosphogluconolactonase activity
ZPR_2015	COG0745	RESPONSE REGULATOR receiver
ZPR_2017	COG0668	transmembrane transport
ZPR_2018	COG2957	Belongs to the agmatine deiminase family
ZPR_2019	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZPR_2020	COG0545	Peptidyl-prolyl cis-trans isomerase
ZPR_2024	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZPR_2024	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZPR_2028	COG1595	DNA-templated transcription, initiation
ZPR_2029	COG1132	(ABC) transporter
ZPR_2030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZPR_2031	COG0463	Glycosyl transferase, family 2
ZPR_2033	COG0254	rRNA binding
ZPR_2038	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZPR_2040	COG1741	Belongs to the pirin family
ZPR_2047	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ZPR_2053	COG1607	acyl-coa hydrolase
ZPR_2058	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZPR_2060	COG4206	TonB-dependent receptor
ZPR_2069	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ZPR_2072	COG1629	transport
ZPR_2072	COG4206	TonB-dependent receptor
ZPR_2073	COG2936	dipeptidyl-peptidase activity
ZPR_2074	COG2936	dipeptidyl-peptidase activity
ZPR_2075	COG1045	serine acetyltransferase
ZPR_2080	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZPR_2084	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ZPR_2086	COG0069	glutamate synthase activity
ZPR_2087	COG0589	response to stress
ZPR_2093	COG1842	Phage shock protein A
ZPR_2101	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ZPR_2103	COG0670	Belongs to the BI1 family
ZPR_2106	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ZPR_2111	COG0513	Belongs to the DEAD box helicase family
ZPR_2112	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZPR_2113	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZPR_2115	COG1295	ribonuclease BN
ZPR_2118	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ZPR_2119	COG3279	Response regulator of the LytR AlgR family
ZPR_2120	COG0360	Binds together with S18 to 16S ribosomal RNA
ZPR_2121	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZPR_2122	COG0359	binds to the 23S rRNA
ZPR_2124	COG0577	efflux transmembrane transporter activity
ZPR_2125	COG0124	histidyl-tRNA synthetase
ZPR_2129	COG4771	TonB-dependent receptor
ZPR_2134	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_2135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ZPR_2137	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZPR_2144	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_2147	COG0235	Class ii aldolase
ZPR_2148	COG2160	L-arabinose isomerase activity
ZPR_2153	COG4206	TonB-dependent receptor
ZPR_2153	COG1629	transport
ZPR_2159	COG3537	Alpha-1,2-mannosidase
ZPR_2189	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ZPR_2194	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_2203	COG3152	Membrane
ZPR_2206	COG4585	Histidine kinase
ZPR_2208	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZPR_2210	COG3852	Histidine kinase
ZPR_2212	COG2076	Multidrug Resistance protein
ZPR_2213	COG3275	phosphorelay sensor kinase activity
ZPR_2214	COG3279	Response regulator of the LytR AlgR family
ZPR_2216	COG1482	cell wall glycoprotein biosynthetic process
ZPR_2218	COG4974	Belongs to the 'phage' integrase family
ZPR_2223	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZPR_2226	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_2236	COG2207	Transcriptional regulator
ZPR_2236	COG1609	Transcriptional regulator
ZPR_2240	COG1629	transport
ZPR_2240	COG4206	TonB-dependent receptor
ZPR_2251	COG0668	transmembrane transport
ZPR_2252	COG0783	Belongs to the Dps family
ZPR_2256	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_2257	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ZPR_2258	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ZPR_2259	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ZPR_2267	COG0460	homoserine dehydrogenase
ZPR_2267	COG0527	aspartate kinase activity
ZPR_2268	COG0083	homoserine kinase activity
ZPR_2269	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ZPR_2274	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZPR_2275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ZPR_2275	COG4651	solute:proton antiporter activity
ZPR_2277	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZPR_2278	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZPR_2279	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZPR_2281	COG4251	negative regulation of phosphorylation
ZPR_2284	COG0405	Gamma-glutamyltransferase
ZPR_2285	COG1187	pseudouridine synthase activity
ZPR_2288	COG0339	signal peptide processing
ZPR_2291	COG2084	Dehydrogenase
ZPR_2292	COG2116	formate transmembrane transporter activity
ZPR_2293	COG4999	Histidine kinase
ZPR_2293	COG3850	Histidine kinase
ZPR_2293	COG2205	protein histidine kinase activity
ZPR_2293	COG3437	response regulator, receiver
ZPR_2297	COG1215	transferase activity, transferring glycosyl groups
ZPR_2299	COG2217	Heavy metal translocating P-type atpase
ZPR_2301	COG3278	Belongs to the heme-copper respiratory oxidase family
ZPR_2304	COG0348	domain, Protein
ZPR_2312	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZPR_2314	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2321	COG0668	transmembrane transport
ZPR_2323	COG0424	maF-like protein
ZPR_2327	COG1333	cytochrome c biogenesis protein
ZPR_2327	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZPR_2332	COG1393	Belongs to the ArsC family
ZPR_2333	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ZPR_2336	COG2308	Evidence 4 Homologs of previously reported genes of
ZPR_2341	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZPR_2344	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_2351	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZPR_2354	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZPR_2355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ZPR_2356	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ZPR_2358	COG0686	Belongs to the AlaDH PNT family
ZPR_2361	COG0802	atpase or kinase
ZPR_2362	COG2204	response regulator
ZPR_2363	COG1078	dGTPase activity
ZPR_2364	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_2365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZPR_2365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ZPR_2366	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_2367	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZPR_2368	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_2377	COG0612	Peptidase, M16
ZPR_2378	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2381	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZPR_2387	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZPR_2388	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZPR_2389	COG0131	Imidazoleglycerol-phosphate dehydratase
ZPR_2390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZPR_2392	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZPR_2394	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_2397	COG2860	membrane
ZPR_2398	COG0492	ferredoxin-NADP+ reductase activity
ZPR_2410	COG3385	transposase activity
ZPR_2414	COG0714	Associated with various cellular activities
ZPR_2421	COG0494	nUDIX hydrolase
ZPR_2422	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZPR_2427	COG4206	TonB-dependent receptor
ZPR_2427	COG1629	transport
ZPR_2429	COG3275	phosphorelay sensor kinase activity
ZPR_2432	COG3279	Response regulator of the LytR AlgR family
ZPR_2435	COG1595	DNA-templated transcription, initiation
ZPR_2439	COG0673	inositol 2-dehydrogenase activity
ZPR_2440	COG2211	Major facilitator Superfamily
ZPR_2449	COG4206	TonB-dependent receptor
ZPR_2449	COG1629	transport
ZPR_2456	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ZPR_2459	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ZPR_2461	COG3387	PFAM Glycoside hydrolase 15-related
ZPR_2467	COG1960	acyl-CoA dehydrogenase activity
ZPR_2468	COG0183	Belongs to the thiolase family
ZPR_2469	COG1250	3-hydroxyacyl-CoA dehydrogenase
ZPR_2469	COG1024	Enoyl-CoA hydratase
ZPR_2470	COG1846	Transcriptional regulator
ZPR_2471	COG1022	Amp-dependent synthetase and ligase
ZPR_2474	COG2356	endonuclease I
ZPR_2475	COG0300	oxidoreductase activity
ZPR_2487	COG3850	Histidine kinase
ZPR_2487	COG2205	protein histidine kinase activity
ZPR_2487	COG3437	response regulator, receiver
ZPR_2487	COG4999	Histidine kinase
ZPR_2488	COG1629	transport
ZPR_2488	COG4206	TonB-dependent receptor
ZPR_2491	COG3250	beta-galactosidase activity
ZPR_2492	COG1501	Belongs to the glycosyl hydrolase 31 family
ZPR_2493	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_2494	COG1940	carbohydrate kinase activity
ZPR_2495	COG0673	inositol 2-dehydrogenase activity
ZPR_2497	COG3250	beta-galactosidase activity
ZPR_2507	COG0662	Cupin 2, conserved barrel domain protein
ZPR_2507	COG2207	Transcriptional regulator
ZPR_2511	COG0584	glycerophosphoryl diester phosphodiesterase
ZPR_2515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ZPR_2525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZPR_2526	COG0514	ATP-dependent DNA helicase (RecQ)
ZPR_2528	COG2921	Belongs to the UPF0250 family
ZPR_2530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZPR_2532	COG4774	siderophore transport
ZPR_2534	COG0321	lipoyl(octanoyl) transferase activity
ZPR_2534	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZPR_2537	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ZPR_2538	COG0857	belongs to the CobB CobQ family
ZPR_2538	COG0280	phosphate acetyltransferase
ZPR_2543	COG2205	protein histidine kinase activity
ZPR_2546	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZPR_2547	COG0302	gtp cyclohydrolase
ZPR_2551	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZPR_2553	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZPR_2555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_2556	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZPR_2557	COG0745	RESPONSE REGULATOR receiver
ZPR_2558	COG5002	protein histidine kinase activity
ZPR_2567	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ZPR_2569	COG1764	response to oxidative stress
ZPR_2571	COG1047	Peptidyl-prolyl cis-trans
ZPR_2572	COG0673	inositol 2-dehydrogenase activity
ZPR_2577	COG0527	aspartate kinase activity
ZPR_2581	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZPR_2582	COG3265	gluconokinase activity
ZPR_2583	COG2610	gluconate transmembrane transporter activity
ZPR_2585	COG0217	transcriptional regulatory protein
ZPR_2586	COG2154	pterin-4-alpha-carbinolamine dehydratase
ZPR_2588	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ZPR_2589	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ZPR_2589	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ZPR_2590	COG2986	histidine ammonia-lyase
ZPR_2592	COG0542	response to heat
ZPR_2593	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZPR_2596	COG0183	Belongs to the thiolase family
ZPR_2602	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_2605	COG1607	acyl-coa hydrolase
ZPR_2606	COG0668	transmembrane transport
ZPR_2608	COG0668	transmembrane transport
ZPR_2609	COG2814	Major facilitator Superfamily
ZPR_2616	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2618	COG2072	flavoprotein involved in K transport
ZPR_2619	COG4221	oxidoreductase activity
ZPR_2620	COG2130	NADP-dependent
ZPR_2622	COG1289	transmembrane transporter activity
ZPR_2626	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZPR_2629	COG1902	pentaerythritol trinitrate reductase activity
ZPR_2631	COG0604	alcohol dehydrogenase
ZPR_2634	COG1917	Cupin 2, conserved barrel domain protein
ZPR_2634	COG2169	Transcriptional regulator
ZPR_2637	COG2211	Major facilitator Superfamily
ZPR_2638	COG0583	DNA-binding transcription factor activity
ZPR_2639	COG2855	membrane
ZPR_2640	COG0698	ribose 5-phosphate isomerase
ZPR_2641	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ZPR_2642	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZPR_2643	COG0363	glucosamine-6-phosphate deaminase activity
ZPR_2647	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ZPR_2648	COG3384	dioxygenase
ZPR_2651	COG2723	6-phospho-beta-galactosidase activity
ZPR_2691	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZPR_2698	COG0023	Translation Initiation Factor
ZPR_2700	COG0813	purine-nucleoside phosphorylase activity
ZPR_2701	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZPR_2704	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ZPR_2705	COG1193	negative regulation of DNA recombination
ZPR_2706	COG3011	Protein conserved in bacteria
ZPR_2710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZPR_2713	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZPR_2715	COG0693	protein deglycase activity
ZPR_2718	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZPR_2719	COG1522	sequence-specific DNA binding
ZPR_2723	COG1970	mechanosensitive ion channel activity
ZPR_2727	COG0012	GTP binding
ZPR_2729	COG2226	methyltransferase
ZPR_2730	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_2731	COG3537	Alpha-1,2-mannosidase
ZPR_2732	COG3537	Alpha-1,2-mannosidase
ZPR_2734	COG0247	lactate metabolic process
ZPR_2736	COG0438	transferase activity, transferring glycosyl groups
ZPR_2737	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_2739	COG0247	lactate metabolic process
ZPR_2739	COG2181	nitrate reductase activity
ZPR_2740	COG0247	lactate metabolic process
ZPR_2740	COG2181	nitrate reductase activity
ZPR_2742	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZPR_2745	COG0251	oxidation-reduction process
ZPR_2746	COG0667	Aldo Keto reductase
ZPR_2748	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ZPR_2750	COG1803	Methylglyoxal synthase
ZPR_2751	COG0205	6-phosphofructokinase activity
ZPR_2753	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZPR_2764	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZPR_2766	COG0726	polysaccharide deacetylase
ZPR_2768	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZPR_2773	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZPR_2775	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2776	COG2986	histidine ammonia-lyase
ZPR_2780	COG4974	Belongs to the 'phage' integrase family
ZPR_2794	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZPR_2795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZPR_2796	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ZPR_2797	COG0137	argininosuccinate synthase activity
ZPR_2799	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZPR_2800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZPR_2802	COG0028	Belongs to the TPP enzyme family
ZPR_2804	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZPR_2804	COG3153	acetyltransferase
ZPR_2806	COG1984	allophanate hydrolase subunit 2
ZPR_2807	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ZPR_2809	COG1914	H( )-stimulated, divalent metal cation uptake system
ZPR_2811	COG0606	chelatase, subunit chli
ZPR_2813	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZPR_2814	COG0205	6-phosphofructokinase activity
ZPR_2815	COG0366	Alpha amylase catalytic
ZPR_2816	COG0366	Alpha amylase catalytic
ZPR_2817	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_2818	COG1554	hydrolase, family 65, central catalytic
ZPR_2819	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZPR_2822	COG4206	TonB-dependent receptor
ZPR_2822	COG1629	transport
ZPR_2823	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZPR_2825	COG0366	Alpha amylase catalytic
ZPR_2833	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ZPR_2834	COG1085	galactose-1-phosphate uridylyltransferase
ZPR_2839	COG4232	protein-disulfide reductase activity
ZPR_2840	COG0037	tRNA processing
ZPR_2844	COG0513	Belongs to the DEAD box helicase family
ZPR_2846	COG3275	phosphorelay sensor kinase activity
ZPR_2848	COG3279	Response regulator of the LytR AlgR family
ZPR_2851	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_2854	COG0450	alkyl hydroperoxide reductase
ZPR_2860	COG1674	ftsk spoiiie
ZPR_2864	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZPR_2864	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZPR_2870	COG4771	TonB-dependent receptor
ZPR_2871	COG0561	phosphatase activity
ZPR_2875	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_2876	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZPR_2877	COG0420	3'-5' exonuclease activity
ZPR_2878	COG0419	ATPase involved in DNA repair
ZPR_2880	COG1272	protein, Hemolysin III
ZPR_2895	COG0673	inositol 2-dehydrogenase activity
ZPR_2898	COG1629	transport
ZPR_2898	COG4206	TonB-dependent receptor
ZPR_2906	COG2201	protein-glutamate methylesterase activity
ZPR_2907	COG3530	Putative quorum-sensing-regulated virulence factor
ZPR_2908	COG0504	CTP synthase activity
ZPR_2909	COG0706	membrane insertase activity
ZPR_2913	COG0519	Catalyzes the synthesis of GMP from XMP
ZPR_2913	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZPR_2914	COG1388	LysM domain
ZPR_2914	COG3942	CHAP domain
ZPR_2917	COG1335	isochorismatase
ZPR_2921	COG0482	sulfurtransferase activity
ZPR_2927	COG3002	Belongs to the UPF0753 family
ZPR_2928	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ZPR_2929	COG0076	glutamate decarboxylase activity
ZPR_2930	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ZPR_2935	COG1501	Belongs to the glycosyl hydrolase 31 family
ZPR_2936	COG1629	transport
ZPR_2936	COG4206	TonB-dependent receptor
ZPR_2937	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZPR_2938	COG3250	beta-galactosidase activity
ZPR_2939	COG0702	epimerase
ZPR_2943	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZPR_2952	COG2721	sulfolactate sulfo-lyase activity
ZPR_2953	COG0246	Mannitol dehydrogenase
ZPR_2955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ZPR_2957	COG0800	Aldolase
ZPR_2958	COG1304	FMN binding
ZPR_2960	COG1904	glucuronate isomerase
ZPR_2961	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2962	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ZPR_2968	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_2970	COG1312	Catalyzes the dehydration of D-mannonate
ZPR_2971	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ZPR_2973	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ZPR_2974	COG2010	Cytochrome c
ZPR_2974	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ZPR_2975	COG2080	2 iron, 2 sulfur cluster binding
ZPR_2977	COG0314	molybdopterin synthase activity
ZPR_2978	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ZPR_2979	COG0315	cyclic pyranopterin monophosphate synthase activity
ZPR_2980	COG0746	molybdenum cofactor guanylyltransferase activity
ZPR_2980	COG0315	cyclic pyranopterin monophosphate synthase activity
ZPR_2981	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZPR_2985	COG3842	ATPase activity
ZPR_2986	COG0303	'Molybdopterin
ZPR_2987	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ZPR_2988	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ZPR_2989	COG2080	2 iron, 2 sulfur cluster binding
ZPR_2991	COG0673	inositol 2-dehydrogenase activity
ZPR_2995	COG2115	Belongs to the xylose isomerase family
ZPR_2997	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_3019	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_3019	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZPR_3024	COG0477	Major facilitator Superfamily
ZPR_3024	COG2814	Major facilitator Superfamily
ZPR_3031	COG1609	Transcriptional regulator
ZPR_3033	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ZPR_3034	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ZPR_3035	COG1904	glucuronate isomerase
ZPR_3036	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_3037	COG3661	Belongs to the glycosyl hydrolase 67 family
ZPR_3038	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_3042	COG1629	transport
ZPR_3042	COG4206	TonB-dependent receptor
ZPR_3043	COG0671	phosphoesterase, PA-phosphatase related
ZPR_3045	COG0534	Mate efflux family protein
ZPR_3049	COG0071	Belongs to the small heat shock protein (HSP20) family
ZPR_3051	COG4585	Histidine kinase
ZPR_3052	COG2197	response regulator
ZPR_3053	COG0488	(ABC) transporter
ZPR_3056	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ZPR_3062	COG1266	CAAX protease self-immunity
ZPR_3063	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_3064	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ZPR_3065	COG1575	Belongs to the MenA family. Type 1 subfamily
ZPR_3069	COG1360	Flagellar Motor Protein
ZPR_3070	COG2267	carboxylic ester hydrolase activity
ZPR_3073	COG1629	transport
ZPR_3073	COG4206	TonB-dependent receptor
ZPR_3075	COG2885	chlorophyll binding
ZPR_3081	COG0668	transmembrane transport
ZPR_3088	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_3090	COG4106	trans-aconitate 2-methyltransferase activity
ZPR_3093	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZPR_3096	COG0242	peptide deformylase activity
ZPR_3097	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZPR_3098	COG2171	N-acyltransferase activity
ZPR_3103	COG0009	L-threonylcarbamoyladenylate synthase
ZPR_3113	COG0556	nucleotide-excision repair
ZPR_3115	COG2204	response regulator
ZPR_3117	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ZPR_3117	COG3264	Mechanosensitive ion channel
ZPR_3118	COG1668	transmembrane transport
ZPR_3119	COG4152	abc transporter atp-binding protein
ZPR_3121	COG0484	heat shock protein binding
ZPR_3122	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZPR_3125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ZPR_3125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZPR_3127	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZPR_3133	COG0347	Belongs to the P(II) protein family
ZPR_3134	COG0004	ammonium transporteR
ZPR_3140	COG1522	sequence-specific DNA binding
ZPR_3142	COG2095	MarC family integral membrane protein
ZPR_3143	COG1703	isobutyryl-CoA mutase activity
ZPR_3143	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_3143	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_3144	COG0788	formyltetrahydrofolate deformylase activity
ZPR_3145	COG0753	catalase activity
ZPR_3148	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZPR_3149	COG0284	orotidine-5'-phosphate decarboxylase activity
ZPR_3150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZPR_3151	COG1131	(ABC) transporter
ZPR_3153	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZPR_3155	COG0174	glutamine synthetase
ZPR_3169	COG0561	phosphatase activity
ZPR_3170	COG4206	TonB-dependent receptor
ZPR_3170	COG1629	transport
ZPR_3171	COG2814	Major facilitator Superfamily
ZPR_3176	COG4206	TonB-dependent receptor
ZPR_3176	COG1629	transport
ZPR_3183	COG0523	cobalamin synthesis protein
ZPR_3185	COG1785	Belongs to the alkaline phosphatase family
ZPR_3188	COG4206	TonB-dependent receptor
ZPR_3188	COG1629	transport
ZPR_3194	COG1629	transport
ZPR_3194	COG4206	TonB-dependent receptor
ZPR_3196	COG1621	beta-fructofuranosidase activity
ZPR_3197	COG2814	Major facilitator Superfamily
ZPR_3202	COG1595	DNA-templated transcription, initiation
ZPR_3206	COG3511	phospholipase C
ZPR_3217	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_3218	COG1074	ATP-dependent DNA helicase activity
ZPR_3224	COG2234	aminopeptidase activity
ZPR_3227	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ZPR_3230	COG1250	3-hydroxyacyl-CoA dehydrogenase
ZPR_3232	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ZPR_3233	COG0322	excinuclease ABC activity
ZPR_3235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ZPR_3236	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZPR_3241	COG1215	transferase activity, transferring glycosyl groups
ZPR_3242	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZPR_3243	COG0497	DNA recombination
ZPR_3248	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZPR_3250	COG0737	Belongs to the 5'-nucleotidase family
ZPR_3250	COG4085	toxin activity
ZPR_3250	COG1525	nuclease
ZPR_3252	COG0737	Belongs to the 5'-nucleotidase family
ZPR_3254	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZPR_3266	COG4206	TonB-dependent receptor
ZPR_3266	COG1629	transport
ZPR_3272	COG4974	Belongs to the 'phage' integrase family
ZPR_3281	COG2963	transposase activity
ZPR_3282	COG2801	Transposase and inactivated derivatives
ZPR_3303	COG2378	regulation of single-species biofilm formation
ZPR_3321	COG2963	transposase activity
ZPR_3325	COG1309	transcriptional regulator
ZPR_3328	COG0519	Catalyzes the synthesis of GMP from XMP
ZPR_3329	COG1917	Cupin 2, conserved barrel domain protein
ZPR_3329	COG4977	sequence-specific DNA binding
ZPR_3330	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_3341	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ZPR_3344	COG3685	Protein conserved in bacteria
ZPR_3345	COG2124	cytochrome p450
ZPR_3355	COG2801	Transposase and inactivated derivatives
ZPR_3356	COG2801	Transposase and inactivated derivatives
ZPR_3358	COG0401	homolog of Blt101
ZPR_3360	COG3685	Protein conserved in bacteria
ZPR_3361	COG0667	Aldo Keto reductase
ZPR_3364	COG5002	protein histidine kinase activity
ZPR_3370	COG2217	Heavy metal translocating P-type atpase
ZPR_3375	COG0640	Transcriptional regulator
ZPR_3378	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_3384	COG2132	Multicopper oxidase
ZPR_3386	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_3399	COG0531	amino acid
ZPR_3401	COG1830	Aldolase
ZPR_3402	COG1301	dicarboxylic acid transport
ZPR_3403	COG0596	Alpha beta hydrolase
ZPR_3404	COG0205	6-phosphofructokinase activity
ZPR_3405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_3409	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ZPR_3410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ZPR_3411	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZPR_3414	COG2217	Heavy metal translocating P-type atpase
ZPR_3415	COG2814	Major facilitator Superfamily
ZPR_3418	COG4372	Transposase
ZPR_3425	COG1618	nucleotide phosphatase activity, acting on free nucleotides
ZPR_3431	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ZPR_3432	COG4804	nuclease activity
ZPR_3433	COG5290	Psort location Cytoplasmic, score
ZPR_3434	COG0732	type I restriction modification DNA specificity domain
ZPR_3435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ZPR_3443	COG1629	transport
ZPR_3443	COG4206	TonB-dependent receptor
ZPR_3447	COG2207	Transcriptional regulator
ZPR_3450	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_3470	COG3119	arylsulfatase activity
ZPR_3471	COG2382	esterase
ZPR_3471	COG3693	PFAM glycoside hydrolase, family 10
ZPR_3473	COG2272	Belongs to the type-B carboxylesterase lipase family
ZPR_3474	COG2942	2-epimerase
ZPR_3475	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ZPR_3482	COG4206	TonB-dependent receptor
ZPR_3482	COG1629	transport
ZPR_3484	COG4206	TonB-dependent receptor
ZPR_3484	COG1629	transport
ZPR_3489	COG3328	transposase activity
ZPR_3498	COG2827	Endonuclease containing a URI domain
ZPR_3499	COG1610	YqeY-like protein
ZPR_3503	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_3504	COG3119	arylsulfatase activity
ZPR_3515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZPR_3516	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZPR_3517	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZPR_3522	COG1490	D-aminoacyl-tRNA deacylase activity
ZPR_3523	COG1162	GTPase activity
ZPR_3524	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ZPR_3525	COG0287	Prephenate dehydrogenase
ZPR_3526	COG0436	Aminotransferase
ZPR_3527	COG0077	Prephenate dehydratase
ZPR_3527	COG1605	Chorismate mutase
ZPR_3528	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZPR_3529	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_3541	COG3590	peptidase
ZPR_3545	COG4974	Belongs to the 'phage' integrase family
ZPR_3548	COG2801	Transposase and inactivated derivatives
ZPR_3552	COG0612	Peptidase, M16
ZPR_3555	COG1629	transport
ZPR_3555	COG4206	TonB-dependent receptor
ZPR_3561	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZPR_3571	COG0784	Response regulator, receiver
ZPR_3573	COG4251	negative regulation of phosphorylation
ZPR_3575	COG5002	protein histidine kinase activity
ZPR_3577	COG3279	Response regulator of the LytR AlgR family
ZPR_3579	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZPR_3580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZPR_3583	COG1611	Belongs to the LOG family
ZPR_3584	COG2890	protein-(glutamine-N5) methyltransferase activity
ZPR_3586	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZPR_3586	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZPR_3587	COG1011	Hydrolase
ZPR_3588	COG1739	Uncharacterized protein family UPF0029
ZPR_3590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZPR_3591	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZPR_3592	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZPR_3594	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZPR_3596	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZPR_3597	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZPR_3602	COG0336	Belongs to the RNA methyltransferase TrmD family
ZPR_3603	COG0335	large ribosomal subunit rRNA binding
ZPR_3605	COG2814	Major facilitator Superfamily
ZPR_3614	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZPR_3615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZPR_3617	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZPR_3623	COG0460	homoserine dehydrogenase
ZPR_3623	COG0527	aspartate kinase activity
ZPR_3624	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ZPR_3626	COG1410	methionine synthase
ZPR_3626	COG0646	methionine synthase
ZPR_3627	COG1765	OsmC-like protein
ZPR_3628	COG0492	ferredoxin-NADP+ reductase activity
ZPR_3629	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZPR_3629	COG1648	precorrin-2 dehydrogenase activity
ZPR_3631	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZPR_3633	COG1959	2 iron, 2 sulfur cluster binding
ZPR_3636	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZPR_3639	COG1960	acyl-CoA dehydrogenase activity
ZPR_3640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZPR_3645	COG3273	potassium ion transport
ZPR_3645	COG0471	metal ion transport
ZPR_3649	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_3650	COG2207	Transcriptional regulator
ZPR_3651	COG1428	Deoxynucleoside kinase
ZPR_3655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ZPR_3656	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZPR_3658	COG0022	dehydrogenase e1 component
ZPR_3658	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_3660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ZPR_3662	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZPR_3665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZPR_3674	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZPR_3677	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZPR_3683	COG0673	inositol 2-dehydrogenase activity
ZPR_3685	COG1519	Transferase
ZPR_3685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZPR_3694	COG4206	TonB-dependent receptor
ZPR_3694	COG1629	transport
ZPR_3697	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ZPR_3703	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ZPR_3710	COG2249	NAD(P)H dehydrogenase (quinone) activity
ZPR_3719	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZPR_3722	COG1119	ATPase activity
ZPR_3723	COG0657	acetylesterase activity
ZPR_3723	COG2755	lipolytic protein G-D-S-L family
ZPR_3726	COG1132	(ABC) transporter
ZPR_3734	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_3737	COG1428	Deoxynucleoside kinase
ZPR_3740	COG0525	valine-tRNA ligase activity
ZPR_3742	COG0436	Aminotransferase
ZPR_3743	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZPR_3746	COG1216	Glycosyl transferase, family 2
ZPR_3748	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZPR_3750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZPR_3752	COG1663	tetraacyldisaccharide 4'-kinase activity
ZPR_3753	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ZPR_3757	COG3263	regulation of cellular component size
ZPR_3758	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZPR_3762	COG0415	Belongs to the DNA photolyase family
ZPR_3763	COG3046	protein related to deoxyribodipyrimidine photolyase
ZPR_3764	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_3767	COG3844	kynureninase activity
ZPR_3769	COG0671	phosphoesterase, PA-phosphatase related
ZPR_3770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZPR_3777	COG3340	Belongs to the peptidase S51 family
ZPR_3778	COG2066	Belongs to the glutaminase family
ZPR_3781	COG0442	prolyl-tRNA aminoacylation
ZPR_3785	COG0302	gtp cyclohydrolase
ZPR_3786	COG0215	cysteine-tRNA ligase activity
ZPR_3787	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZPR_3788	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZPR_3791	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZPR_3793	COG0187	DNA topoisomerase II activity
ZPR_3795	COG0602	queuosine metabolic process
ZPR_3800	COG1619	proteins homologs of microcin C7 resistance protein MccF
ZPR_3804	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZPR_3807	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZPR_3808	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZPR_3810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZPR_3811	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZPR_3812	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZPR_3813	COG0768	penicillin binding
ZPR_3815	COG0275	rRNA processing
ZPR_3816	COG2001	Belongs to the MraZ family
ZPR_3818	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZPR_3823	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ZPR_3824	COG2197	response regulator
ZPR_3825	COG0358	DNA primase activity
ZPR_3830	COG1187	pseudouridine synthase activity
ZPR_3834	COG3339	Conserved Protein
ZPR_3835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZPR_3836	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZPR_3837	COG0018	arginyl-trna synthetase
ZPR_3839	COG2095	MarC family integral membrane protein
ZPR_3842	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ZPR_3846	COG0297	glycogen (starch) synthase activity
ZPR_3847	COG0148	phosphopyruvate hydratase activity
ZPR_3848	COG0505	Belongs to the CarA family
ZPR_3849	COG0203	ribosomal protein L17
ZPR_3850	COG0202	RNA polymerase activity
ZPR_3851	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZPR_3852	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZPR_3853	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZPR_3854	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZPR_3856	COG0200	Binds to the 23S rRNA
ZPR_3857	COG1841	ribosomal large subunit assembly
ZPR_3858	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZPR_3859	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZPR_3860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZPR_3861	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZPR_3862	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZPR_3863	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZPR_3864	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZPR_3865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZPR_3866	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZPR_3867	COG0255	Belongs to the universal ribosomal protein uL29 family
ZPR_3868	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZPR_3869	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZPR_3870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZPR_3871	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZPR_3872	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZPR_3873	COG0089	rRNA binding
ZPR_3874	COG0088	Forms part of the polypeptide exit tunnel
ZPR_3875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZPR_3876	COG0051	transcription antitermination factor activity, RNA binding
ZPR_3877	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZPR_3878	COG0049	tRNA binding
ZPR_3879	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZPR_3880	COG4206	TonB-dependent receptor
ZPR_3880	COG1629	transport
ZPR_3882	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZPR_3888	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZPR_3892	COG2003	Belongs to the UPF0758 family
ZPR_3893	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZPR_3898	COG2373	Large extracellular alpha-helical protein
ZPR_3900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZPR_3901	COG0563	adenylate kinase activity
ZPR_3903	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZPR_3904	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZPR_3906	COG0339	signal peptide processing
ZPR_3910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ZPR_3910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ZPR_3911	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZPR_3915	COG1215	transferase activity, transferring glycosyl groups
ZPR_3917	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZPR_3918	COG1127	ABC transporter
ZPR_3921	COG0300	oxidoreductase activity
ZPR_3924	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZPR_3925	COG0295	cytidine deaminase activity
ZPR_3927	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_3928	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ZPR_3931	COG0285	dihydrofolate synthase activity
ZPR_3933	COG0848	biopolymer transport protein
ZPR_3934	COG0811	peptide transport
ZPR_3935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZPR_3937	COG1960	acyl-CoA dehydrogenase activity
ZPR_3938	COG0067	glutamate synthase
ZPR_3938	COG0070	glutamate synthase
ZPR_3938	COG0069	glutamate synthase activity
ZPR_3942	COG0563	adenylate kinase activity
ZPR_3967	COG1733	regulation of RNA biosynthetic process
ZPR_3981	COG4372	Transposase
ZPR_3983	COG4974	Belongs to the 'phage' integrase family
ZPR_4014	COG2003	Belongs to the UPF0758 family
ZPR_4015	COG0629	single-stranded DNA binding
ZPR_4033	COG2814	Major facilitator Superfamily
ZPR_4052	COG0723	plastoquinol--plastocyanin reductase activity
ZPR_4058	COG0531	amino acid
ZPR_4061	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZPR_4063	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZPR_4064	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_4067	COG2132	Multicopper oxidase
ZPR_4068	COG2217	Heavy metal translocating P-type atpase
ZPR_4071	COG3781	membrane
ZPR_4080	COG0347	Belongs to the P(II) protein family
ZPR_4093	COG4206	TonB-dependent receptor
ZPR_4093	COG1629	transport
ZPR_4095	COG0612	Peptidase, M16
ZPR_4097	COG1609	Transcriptional regulator
ZPR_4097	COG2207	Transcriptional regulator
ZPR_4102	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ZPR_4105	COG1309	transcriptional regulator
ZPR_4106	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_4107	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_4109	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ZPR_4122	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ZPR_4133	COG2003	Belongs to the UPF0758 family
ZPR_4134	COG0629	single-stranded DNA binding
ZPR_4144	COG0488	(ABC) transporter
ZPR_4150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_4152	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZPR_4152	COG1754	DNA topoisomerase type I activity
ZPR_4153	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZPR_4158	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZPR_4159	COG0459	protein refolding
ZPR_4161	COG3142	Participates in the control of copper homeostasis
ZPR_4168	COG0471	metal ion transport
ZPR_4176	COG1629	transport
ZPR_4176	COG4206	TonB-dependent receptor
ZPR_4178	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZPR_4179	COG3537	Alpha-1,2-mannosidase
ZPR_4182	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ZPR_4184	COG3537	Alpha-1,2-mannosidase
ZPR_4186	COG3279	Response regulator of the LytR AlgR family
ZPR_4191	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ZPR_4192	COG2226	methyltransferase
ZPR_4195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZPR_4198	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ZPR_4199	COG0463	Glycosyl transferase, family 2
ZPR_4205	COG0010	Belongs to the arginase family
ZPR_4207	COG1187	pseudouridine synthase activity
ZPR_4211	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ZPR_4212	COG2081	HI0933 family
ZPR_4214	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_4215	COG2323	membrane
ZPR_4217	COG0861	Integral membrane protein TerC family
ZPR_4220	COG0673	inositol 2-dehydrogenase activity
ZPR_4221	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_4224	COG1629	transport
ZPR_4224	COG4206	TonB-dependent receptor
ZPR_4227	COG1629	transport
ZPR_4227	COG4206	TonB-dependent receptor
ZPR_4234	COG2217	Heavy metal translocating P-type atpase
ZPR_4235	COG2207	Transcriptional regulator
ZPR_4240	COG2217	Heavy metal translocating P-type atpase
ZPR_4249	COG0069	glutamate synthase activity
ZPR_4257	COG2132	Multicopper oxidase
ZPR_4260	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_4269	COG0629	single-stranded DNA binding
ZPR_4270	COG0629	single-stranded DNA binding
ZPR_4275	COG2814	Major facilitator Superfamily
ZPR_4284	COG1475	DNA binding
ZPR_4287	COG0739	heme binding
ZPR_4292	COG2315	Protein conserved in bacteria
ZPR_4297	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZPR_4298	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZPR_4302	COG3063	Type IV pilus biogenesis stability protein PilW
ZPR_4304	COG4219	Peptidase M56
ZPR_4304	COG2602	Beta-lactamase
ZPR_4309	COG0784	Response regulator, receiver
ZPR_4309	COG2198	Histidine kinase
ZPR_4309	COG5002	protein histidine kinase activity
ZPR_4311	COG1346	cytolysis
ZPR_4312	COG1380	Effector of murein hydrolase LrgA
ZPR_4314	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZPR_4315	COG2072	flavoprotein involved in K transport
ZPR_4320	COG1607	acyl-coa hydrolase
ZPR_4322	COG4221	oxidoreductase activity
ZPR_4333	COG3250	beta-galactosidase activity
ZPR_4336	COG2017	converts alpha-aldose to the beta-anomer
ZPR_4338	COG3940	Belongs to the glycosyl hydrolase 43 family
ZPR_4343	COG5002	protein histidine kinase activity
ZPR_4346	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_4352	COG1522	sequence-specific DNA binding
ZPR_4353	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZPR_4354	COG0778	Nitroreductase
ZPR_4358	COG3254	rhamnose metabolic process
ZPR_4359	COG0738	Major facilitator superfamily
ZPR_4361	COG3618	amidohydrolase
ZPR_4362	COG1063	alcohol dehydrogenase
ZPR_4364	COG4977	sequence-specific DNA binding
ZPR_4365	COG2207	Transcriptional regulator
ZPR_4366	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_4368	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_4369	COG0179	Fumarylacetoacetate (FAA) hydrolase
ZPR_4371	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_4375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_4376	COG1966	Carbon starvation protein
ZPR_4383	COG1629	transport
ZPR_4383	COG4206	TonB-dependent receptor
ZPR_4384	COG3537	Alpha-1,2-mannosidase
ZPR_4385	COG2188	Transcriptional regulator
ZPR_4386	COG3119	arylsulfatase activity
ZPR_4389	COG1629	transport
ZPR_4389	COG4206	TonB-dependent receptor
ZPR_4395	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_4406	COG3177	Filamentation induced by cAMP protein fic
ZPR_4416	COG2003	Belongs to the UPF0758 family
ZPR_4417	COG0629	single-stranded DNA binding
ZPR_4424	COG2827	Endonuclease containing a URI domain
ZPR_4425	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ZPR_4430	COG3118	belongs to the thioredoxin family
ZPR_4432	COG3275	phosphorelay sensor kinase activity
ZPR_4433	COG3279	Response regulator of the LytR AlgR family
ZPR_4435	COG0228	four-way junction DNA binding
ZPR_4436	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZPR_4437	COG0495	leucyl-tRNA aminoacylation
ZPR_4439	COG2177	Part of the ABC transporter FtsEX involved in
ZPR_4441	COG1968	undecaprenyl-diphosphatase activity
ZPR_4442	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZPR_4445	COG0519	Catalyzes the synthesis of GMP from XMP
ZPR_4447	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZPR_4449	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ZPR_4450	COG5002	protein histidine kinase activity
ZPR_4453	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZPR_4456	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_4461	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ZPR_4467	COG1733	regulation of RNA biosynthetic process
ZPR_4468	COG0702	epimerase
ZPR_4469	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ZPR_4471	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZPR_4479	COG3279	Response regulator of the LytR AlgR family
ZPR_4480	COG4585	Histidine kinase
ZPR_4481	COG3279	Response regulator of the LytR AlgR family
ZPR_4482	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZPR_4483	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZPR_4485	COG0612	Peptidase, M16
ZPR_4486	COG0612	Peptidase, M16
ZPR_4492	COG0776	regulation of translation
ZPR_4493	COG1530	ribonuclease E activity
ZPR_4495	COG2137	regulation of response to DNA damage stimulus
ZPR_4499	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZPR_4500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZPR_4501	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZPR_4502	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZPR_4503	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_4504	COG1320	monovalent cation:proton antiporter activity
ZPR_4505	COG2212	antiporter activity
ZPR_4508	COG1006	Multisubunit Na H antiporter MnhC subunit
ZPR_4509	COG2111	Na H antiporter
ZPR_4512	COG3655	Transcriptional regulator
ZPR_4514	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZPR_4515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZPR_4516	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZPR_4518	COG0297	glycogen (starch) synthase activity
ZPR_4519	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ZPR_4520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ZPR_4523	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ZPR_4527	COG0667	Aldo Keto reductase
ZPR_4528	COG1360	Flagellar Motor Protein
ZPR_4529	COG0708	Exodeoxyribonuclease III
ZPR_4531	COG2738	Putative neutral zinc metallopeptidase
ZPR_4532	COG0528	UMP kinase activity
ZPR_4533	COG0233	cytoplasmic translational termination
ZPR_4536	COG0017	Asparaginyl-tRNA synthetase
ZPR_4538	COG0564	pseudouridine synthase activity
ZPR_4539	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZPR_4543	COG0848	biopolymer transport protein
ZPR_4545	COG0811	peptide transport
ZPR_4547	COG0252	asparaginase activity
ZPR_4549	COG0084	hydrolase, TatD family'
ZPR_4552	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_4553	COG0567	Dehydrogenase, E1 component
ZPR_4556	COG1309	transcriptional regulator
ZPR_4561	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZPR_4565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_4568	COG3590	peptidase
ZPR_4570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZPR_4571	COG0792	nuclease activity
ZPR_4573	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZPR_4573	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZPR_4577	COG0123	including yeast histone deacetylase and acetoin utilization protein
ZPR_4579	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZPR_4580	COG0629	single-stranded DNA binding
ZPR_4587	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZPR_4596	COG0517	IMP dehydrogenase activity
ZPR_4599	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZPR_4601	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_4605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ZPR_4607	COG1573	uracil-dna glycosylase
ZPR_4608	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZPR_4610	COG1435	thymidine kinase activity
ZPR_4611	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZPR_4612	COG1970	mechanosensitive ion channel activity
ZPR_4613	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZPR_4614	COG1505	serine-type exopeptidase activity
ZPR_4618	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZPR_4620	COG0439	Biotin carboxylase
ZPR_4621	COG0511	ligase activity, forming carbon-carbon bonds
ZPR_4622	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZPR_4623	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ZPR_4625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZPR_4626	COG0307	riboflavin synthase, alpha
ZPR_4628	COG4191	Histidine kinase
ZPR_4629	COG2204	response regulator
ZPR_4631	COG1136	(ABC) transporter
ZPR_4633	COG0577	efflux transmembrane transporter activity
ZPR_4634	COG0577	efflux transmembrane transporter activity
ZPR_4635	COG1136	(ABC) transporter
ZPR_4635	COG0577	efflux transmembrane transporter activity
ZPR_4637	COG0577	efflux transmembrane transporter activity
ZPR_4637	COG1136	(ABC) transporter
ZPR_4639	COG0577	efflux transmembrane transporter activity
ZPR_4639	COG1136	(ABC) transporter
ZPR_4640	COG0577	efflux transmembrane transporter activity
ZPR_4641	COG0577	efflux transmembrane transporter activity
ZPR_4641	COG1136	(ABC) transporter
ZPR_4642	COG0577	efflux transmembrane transporter activity
ZPR_4644	COG1136	(ABC) transporter
ZPR_4644	COG0577	efflux transmembrane transporter activity
ZPR_4652	COG1629	transport
ZPR_4652	COG4206	TonB-dependent receptor
ZPR_4655	COG4206	TonB-dependent receptor
ZPR_4655	COG1629	transport
ZPR_4657	COG0673	inositol 2-dehydrogenase activity
ZPR_4662	COG1629	transport
ZPR_4662	COG4206	TonB-dependent receptor
ZPR_4665	COG3279	Response regulator of the LytR AlgR family
ZPR_4672	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ZPR_4673	COG0732	type I restriction modification DNA specificity domain
ZPR_4675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ZPR_4677	COG3541	Predicted nucleotidyltransferase
ZPR_4679	COG3279	Response regulator of the LytR AlgR family
ZPR_4680	COG3275	phosphorelay sensor kinase activity
ZPR_4684	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_4689	COG0346	lactoylglutathione lyase activity
ZPR_4690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZPR_4691	COG4591	ABC-type transport system involved in lipoprotein release permease component
ZPR_4696	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_4698	COG1940	carbohydrate kinase activity
ZPR_4699	COG0363	glucosamine-6-phosphate deaminase activity
ZPR_4703	COG1629	transport
ZPR_4703	COG4206	TonB-dependent receptor
ZPR_4704	COG0405	Gamma-glutamyltransferase
ZPR_4705	COG0791	NLP P60 protein
ZPR_4706	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_4707	COG1649	PFAM Uncharacterised BCR, COG1649
ZPR_4716	COG1349	DNA-binding transcription factor activity
ZPR_4717	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate