locus-tag	class	description
INR75_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INR75_00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INR75_00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INR75_00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
INR75_00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INR75_00060	COG0336	Belongs to the RNA methyltransferase TrmD family
INR75_00065	COG0335	large ribosomal subunit rRNA binding
INR75_00075	COG2814	Major facilitator Superfamily
INR75_00110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INR75_00115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INR75_00120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INR75_00125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INR75_00135	COG1404	Belongs to the peptidase S8 family
INR75_00140	COG1054	Belongs to the UPF0176 family
INR75_00145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INR75_00155	COG0778	Nitroreductase
INR75_00160	COG2353	YceI-like domain
INR75_00165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INR75_00170	COG0512	Glutamine amidotransferase of anthranilate synthase
INR75_00170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INR75_00175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INR75_00180	COG0134	indole-3-glycerol-phosphate synthase activity
INR75_00185	COG0135	phosphoribosylanthranilate isomerase activity
INR75_00190	COG0133	tryptophan synthase activity
INR75_00195	COG0159	tryptophan synthase activity
INR75_00220	COG3022	response to hydroperoxide
INR75_00225	COG0564	pseudouridine synthase activity
INR75_00235	COG1181	Belongs to the D-alanine--D-alanine ligase family
INR75_00245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INR75_00275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INR75_00285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
INR75_00285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
INR75_00290	COG0799	negative regulation of ribosome biogenesis
INR75_00295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INR75_00305	COG4589	Belongs to the CDS family
INR75_00310	COG0688	phosphatidylethanolamine metabolic process
INR75_00320	COG0525	valine-tRNA ligase activity
INR75_00330	COG0436	Aminotransferase
INR75_00335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INR75_00360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INR75_00365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INR75_00375	COG1663	tetraacyldisaccharide 4'-kinase activity
INR75_00380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INR75_00400	COG3263	regulation of cellular component size
INR75_00405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
INR75_00425	COG0415	Belongs to the DNA photolyase family
INR75_00430	COG3046	protein related to deoxyribodipyrimidine photolyase
INR75_00440	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_00455	COG3844	kynureninase activity
INR75_00465	COG0671	phosphoesterase, PA-phosphatase related
INR75_00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INR75_00505	COG3340	Belongs to the peptidase S51 family
INR75_00510	COG2066	Belongs to the glutaminase family
INR75_00515	COG0268	Binds directly to 16S ribosomal RNA
INR75_00530	COG0442	prolyl-tRNA aminoacylation
INR75_00550	COG0302	gtp cyclohydrolase
INR75_00555	COG0215	cysteine-tRNA ligase activity
INR75_00560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INR75_00565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INR75_00585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INR75_00595	COG0187	DNA topoisomerase II activity
INR75_00605	COG0602	queuosine metabolic process
INR75_00615	COG4771	TonB-dependent receptor
INR75_00625	COG1619	proteins homologs of microcin C7 resistance protein MccF
INR75_00660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INR75_00665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INR75_00675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INR75_00680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INR75_00685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INR75_00700	COG0275	rRNA processing
INR75_00705	COG2001	Belongs to the MraZ family
INR75_00710	COG2267	carboxylic ester hydrolase activity
INR75_00715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
INR75_00735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INR75_00740	COG2197	response regulator
INR75_00745	COG0358	DNA primase activity
INR75_00765	COG1187	pseudouridine synthase activity
INR75_00785	COG3339	Conserved Protein
INR75_00800	COG1053	succinate dehydrogenase
INR75_00805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INR75_00810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INR75_00815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INR75_00820	COG0018	arginyl-trna synthetase
INR75_00830	COG2095	MarC family integral membrane protein
INR75_00845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INR75_00870	COG0148	phosphopyruvate hydratase activity
INR75_00880	COG0203	ribosomal protein L17
INR75_00885	COG0202	RNA polymerase activity
INR75_00890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INR75_00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INR75_00900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INR75_00905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INR75_00910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INR75_00920	COG0200	Binds to the 23S rRNA
INR75_00925	COG1841	ribosomal large subunit assembly
INR75_00930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INR75_00935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INR75_00940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INR75_00945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INR75_00950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INR75_00955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INR75_00960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INR75_00965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INR75_00970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INR75_00975	COG0255	Belongs to the universal ribosomal protein uL29 family
INR75_00980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INR75_00985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INR75_00990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INR75_00995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INR75_01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INR75_01005	COG0089	rRNA binding
INR75_01010	COG0088	Forms part of the polypeptide exit tunnel
INR75_01015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INR75_01020	COG0051	transcription antitermination factor activity, RNA binding
INR75_01025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INR75_01030	COG0049	tRNA binding
INR75_01035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INR75_01040	COG1629	transport
INR75_01040	COG4206	TonB-dependent receptor
INR75_01050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INR75_01060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INR75_01080	COG2003	Belongs to the UPF0758 family
INR75_01085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INR75_01120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INR75_01125	COG0563	adenylate kinase activity
INR75_01130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INR75_01135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
INR75_01140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INR75_01145	COG0339	signal peptide processing
INR75_01165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INR75_01165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INR75_01170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INR75_01210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INR75_01215	COG1127	ABC transporter
INR75_01230	COG0300	oxidoreductase activity
INR75_01240	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_01245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
INR75_01250	COG0295	cytidine deaminase activity
INR75_01260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_01265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INR75_01280	COG0285	dihydrofolate synthase activity
INR75_01290	COG0848	biopolymer transport protein
INR75_01295	COG0811	peptide transport
INR75_01300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INR75_01310	COG1960	acyl-CoA dehydrogenase activity
INR75_01315	COG0070	glutamate synthase
INR75_01315	COG0069	glutamate synthase activity
INR75_01315	COG0067	glutamate synthase
INR75_01360	COG1629	transport
INR75_01365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INR75_01370	COG0702	epimerase
INR75_01375	COG4771	TonB-dependent receptor
INR75_01380	COG0702	epimerase
INR75_01390	COG4771	TonB-dependent receptor
INR75_01395	COG0321	lipoyl(octanoyl) transferase activity
INR75_01400	COG0401	homolog of Blt101
INR75_01405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INR75_01420	COG0701	Predicted permease
INR75_01425	COG2217	Heavy metal translocating P-type atpase
INR75_01435	COG4977	sequence-specific DNA binding
INR75_01435	COG1917	Cupin 2, conserved barrel domain protein
INR75_01490	COG0138	bifunctional purine biosynthesis protein purh
INR75_01495	COG1077	Cell shape determining protein MreB Mrl
INR75_01510	COG0768	penicillin binding
INR75_01515	COG0772	Belongs to the SEDS family
INR75_01530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INR75_01540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_01545	COG0791	NLP P60 protein
INR75_01550	COG2333	competence protein COMEC
INR75_01550	COG0658	competence protein
INR75_01560	COG3104	oligopeptide transport
INR75_01565	COG0823	Involved in the tonB-independent uptake of proteins
INR75_01565	COG1506	peptidase
INR75_01585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INR75_01590	COG1253	flavin adenine dinucleotide binding
INR75_01600	COG0457	Tetratricopeptide repeat
INR75_01610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
INR75_01630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INR75_01635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_01640	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_01650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INR75_01660	COG0544	peptidyl-prolyl cis-trans isomerase activity
INR75_01680	COG0596	Alpha beta hydrolase
INR75_01685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
INR75_01695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INR75_01705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INR75_01710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
INR75_01725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INR75_01745	COG1331	Highly conserved protein containing a thioredoxin domain
INR75_01750	COG0668	transmembrane transport
INR75_01755	COG1214	PFAM Peptidase M22, glycoprotease
INR75_01770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_01775	COG0577	efflux transmembrane transporter activity
INR75_01775	COG1136	(ABC) transporter
INR75_01780	COG1136	(ABC) transporter
INR75_01780	COG0577	efflux transmembrane transporter activity
INR75_01785	COG1136	(ABC) transporter
INR75_01795	COG2322	membrane
INR75_01800	COG1999	signal sequence binding
INR75_01815	COG1845	cytochrome c oxidase, subunit III
INR75_01820	COG1845	cytochrome c oxidase, subunit III
INR75_01825	COG0109	protoheme IX farnesyltransferase activity
INR75_01845	COG0509	glycine decarboxylation via glycine cleavage system
INR75_01855	COG0632	four-way junction helicase activity
INR75_01860	COG0280	phosphate acetyltransferase
INR75_01860	COG0281	malic enzyme
INR75_01865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INR75_01870	COG2124	cytochrome p450
INR75_01875	COG2255	four-way junction helicase activity
INR75_01880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
INR75_01905	COG0052	Belongs to the universal ribosomal protein uS2 family
INR75_01910	COG0437	4 iron, 4 sulfur cluster binding
INR75_01915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
INR75_01915	COG2010	Cytochrome c
INR75_01925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INR75_01930	COG0195	Participates in both transcription termination and antitermination
INR75_01930	COG2251	uridine kinase activity
INR75_01935	COG0779	Required for maturation of 30S ribosomal subunits
INR75_01940	COG0589	response to stress
INR75_01980	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
INR75_01985	COG0438	transferase activity, transferring glycosyl groups
INR75_02005	COG0110	maltose O-acetyltransferase activity
INR75_02055	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INR75_02060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_02065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
INR75_02070	COG1218	3'(2'),5'-bisphosphate nucleotidase
INR75_02080	COG0175	sulfate reduction
INR75_02085	COG0529	Catalyzes the synthesis of activated sulfate
INR75_02090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INR75_02090	COG0662	Cupin 2, conserved barrel domain protein
INR75_02140	COG1629	transport
INR75_02150	COG0471	metal ion transport
INR75_02150	COG3273	potassium ion transport
INR75_02180	COG1446	asparaginase
INR75_02190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INR75_02190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INR75_02195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INR75_02200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INR75_02205	COG0052	Belongs to the universal ribosomal protein uS2 family
INR75_02210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INR75_02215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INR75_02240	COG0492	ferredoxin-NADP+ reductase activity
INR75_02250	COG0489	protein tyrosine kinase activity
INR75_02265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INR75_02275	COG5002	protein histidine kinase activity
INR75_02280	COG0745	RESPONSE REGULATOR receiver
INR75_02285	COG4771	TonB-dependent receptor
INR75_02305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INR75_02320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INR75_02325	COG0463	Glycosyl transferase, family 2
INR75_02340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INR75_02345	COG2363	Small membrane protein
INR75_02355	COG1522	sequence-specific DNA binding
INR75_02365	COG1528	Iron-storage protein
INR75_02370	COG0423	glycine-tRNA ligase activity
INR75_02410	COG1201	RNA secondary structure unwinding
INR75_02415	COG1793	dna ligase
INR75_02430	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
INR75_02445	COG0460	homoserine dehydrogenase
INR75_02445	COG0527	aspartate kinase activity
INR75_02455	COG0702	epimerase
INR75_02460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INR75_02470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INR75_02475	COG2239	Acts as a magnesium transporter
INR75_02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INR75_02500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INR75_02510	COG0196	riboflavin kinase activity
INR75_02515	COG0193	aminoacyl-tRNA hydrolase activity
INR75_02520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INR75_02525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INR75_02545	COG4585	Histidine kinase
INR75_02570	COG0793	Belongs to the peptidase S41A family
INR75_02590	COG2095	MarC family integral membrane protein
INR75_02600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
INR75_02610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INR75_02615	COG0590	tRNA wobble adenosine to inosine editing
INR75_02665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INR75_02670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
INR75_02675	COG3720	iron ion transport
INR75_02990	COG3292	Two component regulator propeller
INR75_02990	COG0745	RESPONSE REGULATOR receiver
INR75_02990	COG2205	protein histidine kinase activity
INR75_02995	COG1629	transport
INR75_02995	COG4206	TonB-dependent receptor
INR75_03000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INR75_03010	COG3867	Arabinogalactan endo-beta-1,4-galactanase
INR75_03015	COG3250	beta-galactosidase activity
INR75_03025	COG4974	Belongs to the 'phage' integrase family
INR75_03045	COG2942	2-epimerase
INR75_03050	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INR75_03065	COG2207	Transcriptional regulator
INR75_03070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INR75_03075	COG4771	TonB-dependent receptor
INR75_03080	COG0702	epimerase
INR75_03095	COG3345	alpha-galactosidase
INR75_03100	COG2942	2-epimerase
INR75_03120	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_03130	COG4771	TonB-dependent receptor
INR75_03175	COG0583	DNA-binding transcription factor activity
INR75_03180	COG0753	catalase activity
INR75_03205	COG2003	Belongs to the UPF0758 family
INR75_03210	COG0629	single-stranded DNA binding
INR75_03220	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_03275	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_03285	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_03295	COG2382	esterase
INR75_03295	COG3693	PFAM glycoside hydrolase, family 10
INR75_03300	COG2382	esterase
INR75_03300	COG3693	PFAM glycoside hydrolase, family 10
INR75_03305	COG2382	esterase
INR75_03310	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_03320	COG1609	Transcriptional regulator
INR75_03325	COG0702	epimerase
INR75_03330	COG4771	TonB-dependent receptor
INR75_03405	COG0702	epimerase
INR75_03410	COG1629	transport
INR75_03440	COG4974	Belongs to the 'phage' integrase family
INR75_03485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INR75_03490	COG0626	cystathionine gamma-synthase activity
INR75_03515	COG0429	hydrolase of the alpha beta-hydrolase fold
INR75_03520	COG1561	YicC-like family, N-terminal region
INR75_03525	COG0194	GDP metabolic process
INR75_03530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INR75_03535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INR75_03555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INR75_03580	COG0288	reversible hydration of carbon dioxide
INR75_03585	COG0659	secondary active sulfate transmembrane transporter activity
INR75_03615	COG2304	oxidoreductase activity
INR75_03630	COG0714	Associated with various cellular activities
INR75_03640	COG4221	oxidoreductase activity
INR75_03660	COG3339	Conserved Protein
INR75_03665	COG0793	Belongs to the peptidase S41A family
INR75_03730	COG0662	Cupin 2, conserved barrel domain protein
INR75_03735	COG1446	asparaginase
INR75_03750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_03765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
INR75_03770	COG3118	belongs to the thioredoxin family
INR75_03780	COG2954	triphosphatase activity
INR75_03790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INR75_03805	COG0571	ribonuclease III activity
INR75_03810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INR75_03815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INR75_03820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INR75_03825	COG0328	RNA-DNA hybrid ribonuclease activity
INR75_03835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INR75_03845	COG1074	ATP-dependent DNA helicase activity
INR75_03850	COG0156	8-amino-7-oxononanoate synthase activity
INR75_03885	COG0534	Mate efflux family protein
INR75_03925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INR75_03930	COG2022	thiamine diphosphate biosynthetic process
INR75_03935	COG0352	thiamine-phosphate diphosphorylase activity
INR75_03945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INR75_03955	COG0720	synthase
INR75_03965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_03980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INR75_03980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INR75_03990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
INR75_04000	COG1573	uracil-dna glycosylase
INR75_04005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INR75_04015	COG1435	thymidine kinase activity
INR75_04020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INR75_04025	COG1970	mechanosensitive ion channel activity
INR75_04030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INR75_04035	COG1505	serine-type exopeptidase activity
INR75_04050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INR75_04060	COG0439	Biotin carboxylase
INR75_04065	COG0511	ligase activity, forming carbon-carbon bonds
INR75_04070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INR75_04075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
INR75_04085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INR75_04090	COG0307	riboflavin synthase, alpha
INR75_04105	COG2204	response regulator
INR75_04115	COG0577	efflux transmembrane transporter activity
INR75_04115	COG1136	(ABC) transporter
INR75_04135	COG0577	efflux transmembrane transporter activity
INR75_04135	COG1136	(ABC) transporter
INR75_04145	COG1136	(ABC) transporter
INR75_04145	COG0577	efflux transmembrane transporter activity
INR75_04160	COG3250	beta-galactosidase activity
INR75_04175	COG3250	beta-galactosidase activity
INR75_04190	COG0702	epimerase
INR75_04195	COG4771	TonB-dependent receptor
INR75_04200	COG3292	Two component regulator propeller
INR75_04200	COG2205	protein histidine kinase activity
INR75_04200	COG0745	RESPONSE REGULATOR receiver
INR75_04215	COG0346	lactoylglutathione lyase activity
INR75_04220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INR75_04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
INR75_04240	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_04250	COG1846	Transcriptional regulator
INR75_04250	COG1940	carbohydrate kinase activity
INR75_04255	COG0363	glucosamine-6-phosphate deaminase activity
INR75_04265	COG0791	NLP P60 protein
INR75_04270	COG4948	Mandelate Racemase Muconate Lactonizing
INR75_04275	COG1649	PFAM Uncharacterised BCR, COG1649
INR75_04285	COG1629	transport
INR75_04290	COG1349	DNA-binding transcription factor activity
INR75_04295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INR75_04300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INR75_04310	COG0481	GTPase activity
INR75_04320	COG0217	transcriptional regulatory protein
INR75_04325	COG3263	regulation of cellular component size
INR75_04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_04345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INR75_04350	COG0594	ribonuclease P activity
INR75_04355	COG0793	Belongs to the peptidase S41A family
INR75_04360	COG2153	protein acetylation
INR75_04365	COG0698	ribose 5-phosphate isomerase
INR75_04375	COG0557	exoribonuclease II activity
INR75_04395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INR75_04400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INR75_04420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INR75_04430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INR75_04435	COG0445	tRNA wobble uridine modification
INR75_04460	COG0470	DNA polymerase III
INR75_04465	COG0126	phosphoglycerate kinase activity
INR75_04470	COG1388	LysM domain
INR75_04470	COG3942	CHAP domain
INR75_04480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INR75_04485	COG0739	heme binding
INR75_04500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_04505	COG1215	transferase activity, transferring glycosyl groups
INR75_04515	COG0151	Belongs to the GarS family
INR75_04540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
INR75_04575	COG0356	it plays a direct role in the translocation of protons across the membrane
INR75_04580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INR75_04585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INR75_04590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INR75_04595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INR75_04600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INR75_04615	COG0756	dUTP diphosphatase activity
INR75_04620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INR75_04650	COG1607	acyl-coa hydrolase
INR75_04660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INR75_04660	COG0758	DNA mediated transformation
INR75_04665	COG0180	Tryptophanyl-tRNA synthetase
INR75_04700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INR75_04705	COG0826	peptidase U32
INR75_04715	COG1054	Belongs to the UPF0176 family
INR75_04720	COG1774	PSP1 C-terminal conserved region
INR75_04730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INR75_04735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
INR75_04780	COG0113	porphobilinogen synthase activity
INR75_04790	COG0408	coproporphyrinogen oxidase activity
INR75_04805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
INR75_04820	COG0181	hydroxymethylbilane synthase activity
INR75_04825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
INR75_04840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INR75_04850	COG1981	membrane
INR75_04860	COG1024	Enoyl-CoA hydratase
INR75_04875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INR75_04885	COG1418	mRNA catabolic process
INR75_04890	COG0204	Acyl-transferase
INR75_04905	COG0484	heat shock protein binding
INR75_04925	COG4771	TonB-dependent receptor
INR75_04930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INR75_04930	COG1321	iron dependent repressor
INR75_04960	COG1999	signal sequence binding
INR75_04965	COG0750	zinc metalloprotease
INR75_04975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INR75_04980	COG1621	beta-fructofuranosidase activity
INR75_04995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INR75_05000	COG1335	isochorismatase
INR75_05020	COG1381	Involved in DNA repair and RecF pathway recombination
INR75_05080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INR75_05095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INR75_05100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INR75_05110	COG0189	ligase activity
INR75_05120	COG0322	excinuclease ABC activity
INR75_05125	COG1752	Esterase of the alpha-beta hydrolase superfamily
INR75_05135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
INR75_05140	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
INR75_05145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
INR75_05155	COG3483	tryptophan 2,3-dioxygenase activity
INR75_05165	COG0166	Belongs to the GPI family
INR75_05170	COG4771	TonB-dependent receptor
INR75_05180	COG2356	endonuclease I
INR75_05215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INR75_05230	COG2151	metal-sulfur cluster biosynthetic enzyme
INR75_05235	COG2166	iron-sulfur cluster assembly
INR75_05245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INR75_05250	COG0719	Fe-S assembly protein
INR75_05255	COG0396	ATPase activity
INR75_05265	COG0719	Fe-S assembly protein
INR75_05275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INR75_05290	COG0006	proline dipeptidase activity
INR75_05295	COG0367	asparagine synthase
INR75_05305	COG1053	succinate dehydrogenase
INR75_05315	COG0436	Aminotransferase
INR75_05335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_05340	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_05350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INR75_05365	COG0517	IMP dehydrogenase activity
INR75_05375	COG3409	Peptidoglycan-binding domain 1 protein
INR75_05375	COG3773	Cell wall hydrolase
INR75_05410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INR75_05445	COG0629	single-stranded DNA binding
INR75_05450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INR75_05465	COG0123	including yeast histone deacetylase and acetoin utilization protein
INR75_05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INR75_05470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INR75_05480	COG0792	nuclease activity
INR75_05490	COG3590	peptidase
INR75_05505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_05535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INR75_05560	COG1309	transcriptional regulator
INR75_05570	COG0567	Dehydrogenase, E1 component
INR75_05575	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_05585	COG0084	hydrolase, TatD family'
INR75_05595	COG0252	asparaginase activity
INR75_05605	COG0811	peptide transport
INR75_05615	COG0848	biopolymer transport protein
INR75_05635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
INR75_05640	COG0564	pseudouridine synthase activity
INR75_05650	COG0017	Asparaginyl-tRNA synthetase
INR75_05665	COG0233	cytoplasmic translational termination
INR75_05670	COG0528	UMP kinase activity
INR75_05675	COG2738	Putative neutral zinc metallopeptidase
INR75_05685	COG0708	Exodeoxyribonuclease III
INR75_05690	COG1360	Flagellar Motor Protein
INR75_05695	COG0667	Aldo Keto reductase
INR75_05705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INR75_05720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INR75_05725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INR75_05730	COG0297	glycogen (starch) synthase activity
INR75_05740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INR75_05745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INR75_05750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
INR75_05760	COG3655	Transcriptional regulator
INR75_05775	COG2111	Na H antiporter
INR75_05775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INR75_05780	COG2111	Na H antiporter
INR75_05785	COG1006	Multisubunit Na H antiporter MnhC subunit
INR75_05790	COG0651	ATP synthesis coupled electron transport
INR75_05795	COG1863	multisubunit Na H antiporter MnhE subunit
INR75_05800	COG2212	antiporter activity
INR75_05805	COG1320	monovalent cation:proton antiporter activity
INR75_05810	COG0156	8-amino-7-oxononanoate synthase activity
INR75_05820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
INR75_05825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INR75_05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INR75_05835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INR75_05850	COG2137	regulation of response to DNA damage stimulus
INR75_05865	COG1530	ribonuclease E activity
INR75_05870	COG0776	regulation of translation
INR75_05880	COG0629	single-stranded DNA binding
INR75_05900	COG0612	Peptidase, M16
INR75_05905	COG0612	Peptidase, M16
INR75_05915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INR75_05920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INR75_05935	COG1629	transport
INR75_05960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
INR75_05970	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
INR75_05975	COG0702	epimerase
INR75_05980	COG1733	regulation of RNA biosynthetic process
INR75_06000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INR75_06030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INR75_06045	COG2205	protein histidine kinase activity
INR75_06050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
INR75_06060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
INR75_06070	COG0519	Catalyzes the synthesis of GMP from XMP
INR75_06085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INR75_06090	COG1968	undecaprenyl-diphosphatase activity
INR75_06100	COG2177	Part of the ABC transporter FtsEX involved in
INR75_06105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
INR75_06110	COG0495	leucyl-tRNA aminoacylation
INR75_06115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INR75_06120	COG0228	four-way junction DNA binding
INR75_06135	COG3118	belongs to the thioredoxin family
INR75_06150	COG4974	Belongs to the 'phage' integrase family
INR75_06155	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
INR75_06225	COG4974	Belongs to the 'phage' integrase family
INR75_06245	COG4771	TonB-dependent receptor
INR75_06275	COG3360	Dodecin
INR75_06290	COG3685	Protein conserved in bacteria
INR75_06295	COG2124	cytochrome p450
INR75_06305	COG3177	Filamentation induced by cAMP protein fic
INR75_06315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INR75_06320	COG1522	sequence-specific DNA binding
INR75_06345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_06385	COG4221	oxidoreductase activity
INR75_06395	COG1607	acyl-coa hydrolase
INR75_06420	COG2072	flavoprotein involved in K transport
INR75_06430	COG1380	Effector of murein hydrolase LrgA
INR75_06435	COG1346	cytolysis
INR75_06445	COG0784	Response regulator, receiver
INR75_06445	COG2198	Histidine kinase
INR75_06445	COG5002	protein histidine kinase activity
INR75_06505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INR75_06510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INR75_06530	COG2315	Protein conserved in bacteria
INR75_06535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INR75_06550	COG0739	heme binding
INR75_06555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INR75_06775	COG4712	double-strand break repair protein
INR75_06800	COG2197	response regulator
INR75_06875	COG0861	Integral membrane protein TerC family
INR75_06890	COG2323	membrane
INR75_06895	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_06905	COG2081	HI0933 family
INR75_06910	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
INR75_06930	COG1187	pseudouridine synthase activity
INR75_06940	COG0010	Belongs to the arginase family
INR75_06965	COG1215	transferase activity, transferring glycosyl groups
INR75_06970	COG0463	Glycosyl transferase, family 2
INR75_06980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
INR75_07000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INR75_07025	COG3279	Response regulator of the LytR AlgR family
INR75_07045	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INR75_07065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INR75_07075	COG1629	transport
INR75_07090	COG4771	TonB-dependent receptor
INR75_07125	COG0471	metal ion transport
INR75_07170	COG3142	Participates in the control of copper homeostasis
INR75_07180	COG0459	protein refolding
INR75_07185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INR75_07210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INR75_07215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INR75_07215	COG1754	DNA topoisomerase type I activity
INR75_07225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_07255	COG0488	(ABC) transporter
INR75_07260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_07285	COG4771	TonB-dependent receptor
INR75_07295	COG1629	transport
INR75_07295	COG4206	TonB-dependent receptor
INR75_07300	COG0702	epimerase
INR75_07320	COG3292	Two component regulator propeller
INR75_07320	COG2205	protein histidine kinase activity
INR75_07320	COG0745	RESPONSE REGULATOR receiver
INR75_07340	COG0798	PFAM Bile acid sodium symporter
INR75_07370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INR75_07375	COG1349	DNA-binding transcription factor activity
INR75_07390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INR75_07400	COG0386	Belongs to the glutathione peroxidase family
INR75_07405	COG1846	Transcriptional regulator
INR75_07430	COG0659	secondary active sulfate transmembrane transporter activity
INR75_07435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INR75_07440	COG1160	GTP binding
INR75_07470	COG0739	heme binding
INR75_07475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INR75_07510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
INR75_07520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
INR75_07535	COG0110	maltose O-acetyltransferase activity
INR75_07550	COG1428	Deoxynucleoside kinase
INR75_07560	COG0823	Involved in the tonB-independent uptake of proteins
INR75_07570	COG0657	acetylesterase activity
INR75_07570	COG2755	lipolytic protein G-D-S-L family
INR75_07575	COG1119	ATPase activity
INR75_07580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INR75_07610	COG0347	Belongs to the P(II) protein family
INR75_07645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_07650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INR75_07660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INR75_07675	COG0531	amino acid
INR75_07700	COG0723	plastoquinol--plastocyanin reductase activity
INR75_07750	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
INR75_07785	COG2207	Transcriptional regulator
INR75_07785	COG1917	Cupin 2, conserved barrel domain protein
INR75_07790	COG4716	Myosin-crossreactive antigen
INR75_07795	COG1024	Enoyl-CoA hydratase
INR75_07795	COG1250	3-hydroxyacyl-CoA dehydrogenase
INR75_07830	COG4372	Transposase
INR75_07850	COG4974	Belongs to the 'phage' integrase family
INR75_07860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
INR75_07900	COG4771	TonB-dependent receptor
INR75_07905	COG0702	epimerase
INR75_07945	COG1519	Transferase
INR75_07945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INR75_07970	COG1629	transport
INR75_07975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INR75_08010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_08030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INR75_08035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
INR75_08045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INR75_08055	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_08055	COG0022	dehydrogenase e1 component
INR75_08065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INR75_08070	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
INR75_08090	COG1428	Deoxynucleoside kinase
INR75_08095	COG2207	Transcriptional regulator
INR75_08100	COG1012	belongs to the aldehyde dehydrogenase family
INR75_08120	COG0471	metal ion transport
INR75_08120	COG3273	potassium ion transport
INR75_08140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INR75_08150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INR75_08155	COG1960	acyl-CoA dehydrogenase activity
INR75_08175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INR75_08185	COG1959	2 iron, 2 sulfur cluster binding
INR75_08195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
INR75_08205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
INR75_08205	COG1648	precorrin-2 dehydrogenase activity
INR75_08210	COG0492	ferredoxin-NADP+ reductase activity
INR75_08215	COG1765	OsmC-like protein
INR75_08230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INR75_08235	COG0527	aspartate kinase activity
INR75_08235	COG0460	homoserine dehydrogenase
INR75_08250	COG0077	Prephenate dehydratase
INR75_08250	COG1605	Chorismate mutase
INR75_08255	COG0436	Aminotransferase
INR75_08260	COG0287	Prephenate dehydrogenase
INR75_08265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INR75_08270	COG1162	GTPase activity
INR75_08275	COG1490	D-aminoacyl-tRNA deacylase activity
INR75_08300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INR75_08305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INR75_08310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INR75_08345	COG4771	TonB-dependent receptor
INR75_08350	COG0702	epimerase
INR75_08365	COG3119	arylsulfatase activity
INR75_08370	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_08380	COG1610	YqeY-like protein
INR75_08490	COG0156	8-amino-7-oxononanoate synthase activity
INR75_08520	COG4771	TonB-dependent receptor
INR75_08535	COG4974	Belongs to the 'phage' integrase family
INR75_08545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INR75_08570	COG1051	belongs to the nudix hydrolase family
INR75_08575	COG0135	phosphoribosylanthranilate isomerase activity
INR75_08600	COG0798	PFAM Bile acid sodium symporter
INR75_08645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
INR75_08650	COG0604	alcohol dehydrogenase
INR75_08650	COG3321	synthase
INR75_08770	COG0737	Belongs to the 5'-nucleotidase family
INR75_08775	COG0737	Belongs to the 5'-nucleotidase family
INR75_08785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INR75_08810	COG0497	DNA recombination
INR75_08815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INR75_08830	COG0237	dephospho-CoA kinase activity
INR75_08845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INR75_08850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INR75_08865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INR75_08875	COG1250	3-hydroxyacyl-CoA dehydrogenase
INR75_08885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
INR75_08890	COG2234	aminopeptidase activity
INR75_08910	COG2354	Protein conserved in bacteria
INR75_08920	COG0745	RESPONSE REGULATOR receiver
INR75_08980	COG0584	glycerophosphoryl diester phosphodiesterase
INR75_08985	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
INR75_08990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_09000	COG2755	lipolytic protein G-D-S-L family
INR75_09015	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_09020	COG4771	TonB-dependent receptor
INR75_09025	COG0702	epimerase
INR75_09050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
INR75_09060	COG3781	membrane
INR75_09075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
INR75_09080	COG1917	Cupin 2, conserved barrel domain protein
INR75_09080	COG2169	Transcriptional regulator
INR75_09120	COG4771	TonB-dependent receptor
INR75_09125	COG0702	epimerase
INR75_09130	COG3250	beta-galactosidase activity
INR75_09140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_09140	COG3952	Lipid A Biosynthesis
INR75_09145	COG1215	transferase activity, transferring glycosyl groups
INR75_09150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_09155	COG1703	isobutyryl-CoA mutase activity
INR75_09160	COG1764	response to oxidative stress
INR75_09205	COG0653	protein targeting
INR75_09225	COG1136	(ABC) transporter
INR75_09245	COG0488	(ABC) transporter
INR75_09255	COG0489	protein tyrosine kinase activity
INR75_09290	COG1216	Glycosyl transferase, family 2
INR75_09290	COG0463	Glycosyl transferase, family 2
INR75_09330	COG1083	cytidylyl-transferase
INR75_09340	COG2089	acid synthase
INR75_09365	COG2813	Specifically methylates the guanine in position
INR75_09375	COG0438	transferase activity, transferring glycosyl groups
INR75_09385	COG0438	transferase activity, transferring glycosyl groups
INR75_09390	COG0438	transferase activity, transferring glycosyl groups
INR75_09395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INR75_09400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
INR75_09410	COG1137	ATPase activity
INR75_09420	COG0805	protein transport
INR75_09425	COG0517	IMP dehydrogenase activity
INR75_09425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
INR75_09430	COG0514	ATP-dependent DNA helicase (RecQ)
INR75_09455	COG3876	Protein conserved in bacteria
INR75_09460	COG0577	efflux transmembrane transporter activity
INR75_09475	COG1115	amino acid carrier protein
INR75_09515	COG1115	amino acid carrier protein
INR75_09525	COG1960	acyl-CoA dehydrogenase activity
INR75_09530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INR75_09535	COG4974	Belongs to the 'phage' integrase family
INR75_09565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INR75_09585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INR75_09590	COG0081	regulation of translation
INR75_09595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INR75_09600	COG0222	ribosome binding
INR75_09605	COG0085	RNA polymerase activity
INR75_09610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INR75_09625	COG1115	amino acid carrier protein
INR75_09630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INR75_09635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INR75_09655	COG0579	oxidoreductase
INR75_09670	COG0561	phosphatase activity
INR75_09710	COG5002	protein histidine kinase activity
INR75_09710	COG2198	Histidine kinase
INR75_09710	COG0784	Response regulator, receiver
INR75_09720	COG0326	Molecular chaperone. Has ATPase activity
INR75_09735	COG1506	peptidase
INR75_09740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INR75_09770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INR75_09795	COG4181	ATPase activity
INR75_09845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INR75_09865	COG1473	amidohydrolase
INR75_09880	COG0009	L-threonylcarbamoyladenylate synthase
INR75_09890	COG1360	Flagellar Motor Protein
INR75_09895	COG0463	Glycosyl transferase, family 2
INR75_09910	COG1575	Belongs to the MenA family. Type 1 subfamily
INR75_09915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INR75_09925	COG4948	Mandelate Racemase Muconate Lactonizing
INR75_09930	COG1266	CAAX protease self-immunity
INR75_09970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INR75_09985	COG0488	(ABC) transporter
INR75_09990	COG2197	response regulator
INR75_09995	COG4585	Histidine kinase
INR75_10005	COG0071	Belongs to the small heat shock protein (HSP20) family
INR75_10025	COG0534	Mate efflux family protein
INR75_10035	COG0671	phosphoesterase, PA-phosphatase related
INR75_10040	COG4771	TonB-dependent receptor
INR75_10045	COG0702	epimerase
INR75_10060	COG1312	Catalyzes the dehydration of D-mannonate
INR75_10070	COG3661	Belongs to the glycosyl hydrolase 67 family
INR75_10075	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_10080	COG1904	glucuronate isomerase
INR75_10090	COG0800	Aldolase
INR75_10095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
INR75_10110	COG1609	Transcriptional regulator
INR75_10145	COG0477	Major facilitator Superfamily
INR75_10145	COG2814	Major facilitator Superfamily
INR75_10170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INR75_10170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_10175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_10185	COG2115	Belongs to the xylose isomerase family
INR75_10195	COG2080	2 iron, 2 sulfur cluster binding
INR75_10200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
INR75_10205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
INR75_10210	COG0303	'Molybdopterin
INR75_10235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
INR75_10240	COG0746	molybdenum cofactor guanylyltransferase activity
INR75_10245	COG0315	cyclic pyranopterin monophosphate synthase activity
INR75_10250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INR75_10255	COG0314	molybdopterin synthase activity
INR75_10265	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
INR75_10280	COG1312	Catalyzes the dehydration of D-mannonate
INR75_10285	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_10290	COG3401	FG-GAP repeat protein
INR75_10295	COG3250	beta-galactosidase activity
INR75_10300	COG2755	lipolytic protein G-D-S-L family
INR75_10310	COG2755	lipolytic protein G-D-S-L family
INR75_10315	COG3254	rhamnose metabolic process
INR75_10340	COG1629	transport
INR75_10360	COG4771	TonB-dependent receptor
INR75_10375	COG0702	epimerase
INR75_10380	COG4771	TonB-dependent receptor
INR75_10395	COG1304	FMN binding
INR75_10405	COG4952	isomerase
INR75_10410	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_10410	COG3347	Dehydrogenase
INR75_10415	COG2188	Transcriptional regulator
INR75_10420	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INR75_10425	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_10430	COG1904	glucuronate isomerase
INR75_10440	COG0800	Aldolase
INR75_10450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
INR75_10460	COG0246	Mannitol dehydrogenase
INR75_10465	COG2721	sulfolactate sulfo-lyase activity
INR75_10490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_10495	COG0657	acetylesterase activity
INR75_10505	COG2755	lipolytic protein G-D-S-L family
INR75_10530	COG3940	Belongs to the glycosyl hydrolase 43 family
INR75_10535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_10590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INR75_10630	COG1064	alcohol dehydrogenase
INR75_10635	COG1064	alcohol dehydrogenase
INR75_10685	COG1942	4-Oxalocrotonate Tautomerase
INR75_10690	COG0673	inositol 2-dehydrogenase activity
INR75_10695	COG0656	L-ascorbic acid biosynthetic process
INR75_10710	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_10715	COG2814	Major facilitator Superfamily
INR75_10720	COG0702	epimerase
INR75_10725	COG0640	Transcriptional regulator
INR75_10740	COG0702	epimerase
INR75_10745	COG3250	beta-galactosidase activity
INR75_10750	COG0612	Peptidase, M16
INR75_10760	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
INR75_10765	COG0076	glutamate decarboxylase activity
INR75_10775	COG0519	Catalyzes the synthesis of GMP from XMP
INR75_10775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INR75_10805	COG0482	sulfurtransferase activity
INR75_10820	COG0706	membrane insertase activity
INR75_10825	COG0504	CTP synthase activity
INR75_10830	COG3530	Putative quorum-sensing-regulated virulence factor
INR75_10835	COG2201	protein-glutamate methylesterase activity
INR75_10890	COG0494	nUDIX hydrolase
INR75_10900	COG0516	GMP reductase activity
INR75_10910	COG0019	diaminopimelate decarboxylase activity
INR75_10915	COG2814	Major facilitator Superfamily
INR75_10920	COG0045	succinate-CoA ligase (ADP-forming) activity
INR75_10930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INR75_10950	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_10965	COG1064	alcohol dehydrogenase
INR75_10970	COG0028	Belongs to the TPP enzyme family
INR75_10975	COG0626	cystathionine gamma-synthase activity
INR75_10980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
INR75_10995	COG3956	TIGRFAM MazG family protein
INR75_11000	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INR75_11010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INR75_11030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INR75_11050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INR75_11060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INR75_11065	COG0501	Belongs to the peptidase M48B family
INR75_11070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INR75_11080	COG0804	urea catabolic process
INR75_11095	COG2195	Cleaves the N-terminal amino acid of tripeptides
INR75_11110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INR75_11120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INR75_11130	COG0105	UTP biosynthetic process
INR75_11145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INR75_11155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INR75_11165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INR75_11190	COG0681	Belongs to the peptidase S26 family
INR75_11195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INR75_11205	COG1475	DNA binding
INR75_11210	COG1192	Involved in chromosome partitioning
INR75_11215	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_11220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_11220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_11225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_11235	COG0572	uridine kinase
INR75_11245	COG2133	pyrroloquinoline quinone binding
INR75_11255	COG4974	Belongs to the 'phage' integrase family
INR75_11275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INR75_11355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INR75_11435	COG4974	Belongs to the 'phage' integrase family
INR75_11465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
INR75_11565	COG4974	Belongs to the 'phage' integrase family
INR75_11570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INR75_11580	COG0592	DNA-directed DNA polymerase activity
INR75_11605	COG1702	phosphate starvation-inducible protein PhoH
INR75_11610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INR75_11615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INR75_11620	COG2176	DNA-directed DNA polymerase activity
INR75_11645	COG1363	Peptidase, m42
INR75_11690	COG0116	Belongs to the methyltransferase superfamily
INR75_11705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INR75_11710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INR75_11745	COG1104	cysteine desulfurase activity
INR75_11770	COG1418	mRNA catabolic process
INR75_11775	COG0656	L-ascorbic acid biosynthetic process
INR75_11780	COG4974	Belongs to the 'phage' integrase family
INR75_11790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INR75_11805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_11815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INR75_11820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INR75_11835	COG2270	Major facilitator Superfamily
INR75_11860	COG1595	DNA-templated transcription, initiation
INR75_11865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INR75_11870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INR75_11875	COG2814	Major facilitator Superfamily
INR75_11880	COG0539	negative regulation of cytoplasmic translation
INR75_11890	COG2198	Histidine kinase
INR75_11890	COG0643	Histidine kinase
INR75_11890	COG0784	Response regulator, receiver
INR75_11895	COG5002	protein histidine kinase activity
INR75_11935	COG0346	lactoylglutathione lyase activity
INR75_11940	COG4302	ethanolamine ammonia-lyase activity
INR75_11945	COG4303	Ethanolamine ammonia lyase large subunit
INR75_11950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INR75_11960	COG0667	Aldo Keto reductase
INR75_11970	COG1764	response to oxidative stress
INR75_11975	COG1846	Transcriptional regulator
INR75_11985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INR75_11995	COG1335	isochorismatase
INR75_12000	COG0668	transmembrane transport
INR75_12010	COG1082	Xylose isomerase domain protein TIM barrel
INR75_12015	COG0590	tRNA wobble adenosine to inosine editing
INR75_12025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INR75_12030	COG0540	Belongs to the ATCase OTCase family
INR75_12040	COG1234	tRNA 3'-trailer cleavage
INR75_12045	COG0259	pyridoxamine-phosphate oxidase activity
INR75_12050	COG0406	alpha-ribazole phosphatase activity
INR75_12050	COG0494	nUDIX hydrolase
INR75_12055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INR75_12070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INR75_12085	COG0742	ribosomal rna small subunit methyltransferase
INR75_12105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INR75_12110	COG0415	Belongs to the DNA photolyase family
INR75_12115	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_12145	COG0668	transmembrane transport
INR75_12155	COG0424	maF-like protein
INR75_12175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INR75_12175	COG1333	cytochrome c biogenesis protein
INR75_12200	COG1393	Belongs to the ArsC family
INR75_12205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INR75_12220	COG2308	Evidence 4 Homologs of previously reported genes of
INR75_12240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
INR75_12255	COG0156	8-amino-7-oxononanoate synthase activity
INR75_12290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INR75_12300	COG0655	NAD(P)H dehydrogenase (quinone) activity
INR75_12305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INR75_12310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INR75_12320	COG0686	Belongs to the AlaDH PNT family
INR75_12335	COG0802	atpase or kinase
INR75_12340	COG2204	response regulator
INR75_12345	COG1078	dGTPase activity
INR75_12350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_12355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INR75_12355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INR75_12360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_12365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INR75_12370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_12390	COG0612	Peptidase, M16
INR75_12395	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_12410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INR75_12415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INR75_12425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INR75_12430	COG0131	Imidazoleglycerol-phosphate dehydratase
INR75_12435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INR75_12445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INR75_12450	COG0107	imidazoleglycerol-phosphate synthase activity
INR75_12455	COG0140	phosphoribosyl-ATP diphosphatase activity
INR75_12455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INR75_12470	COG1741	Belongs to the pirin family
INR75_12500	COG0101	tRNA pseudouridine synthase activity
INR75_12505	COG0514	ATP-dependent DNA helicase (RecQ)
INR75_12510	COG0598	Magnesium transport protein CorA
INR75_12515	COG2706	6-phosphogluconolactonase activity
INR75_12530	COG0189	ligase activity
INR75_12550	COG0745	RESPONSE REGULATOR receiver
INR75_12560	COG0545	Peptidyl-prolyl cis-trans isomerase
INR75_12575	COG2814	Major facilitator Superfamily
INR75_12580	COG2217	Heavy metal translocating P-type atpase
INR75_12595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INR75_12605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
INR75_12625	COG1830	Aldolase
INR75_12635	COG0531	amino acid
INR75_12690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INR75_12720	COG0347	Belongs to the P(II) protein family
INR75_12750	COG2132	Multicopper oxidase
INR75_12755	COG0531	amino acid
INR75_12850	COG0347	Belongs to the P(II) protein family
INR75_12940	COG0629	single-stranded DNA binding
INR75_12945	COG2003	Belongs to the UPF0758 family
INR75_13065	COG0668	transmembrane transport
INR75_13075	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_13080	COG1764	response to oxidative stress
INR75_13085	COG1846	Transcriptional regulator
INR75_13100	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
INR75_13115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_13120	COG1309	transcriptional regulator
INR75_13135	COG3321	synthase
INR75_13135	COG0604	alcohol dehydrogenase
INR75_13160	COG0463	Glycosyl transferase, family 2
INR75_13165	COG3952	Lipid A Biosynthesis
INR75_13165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_13180	COG0745	RESPONSE REGULATOR receiver
INR75_13185	COG0642	Histidine kinase
INR75_13195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_13200	COG1477	protein flavinylation
INR75_13235	COG2207	Transcriptional regulator
INR75_13240	COG4771	TonB-dependent receptor
INR75_13245	COG0702	epimerase
INR75_13260	COG4124	Belongs to the glycosyl hydrolase 26 family
INR75_13265	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INR75_13315	COG2826	transposase and inactivated derivatives, IS30 family
INR75_13360	COG1678	Uncharacterized ACR, COG1678
INR75_13370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INR75_13375	COG0514	ATP-dependent DNA helicase (RecQ)
INR75_13395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INR75_13415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INR75_13415	COG0321	lipoyl(octanoyl) transferase activity
INR75_13445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INR75_13450	COG0280	phosphate acetyltransferase
INR75_13450	COG0857	belongs to the CobB CobQ family
INR75_13475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INR75_13485	COG2205	protein histidine kinase activity
INR75_13495	COG1136	(ABC) transporter
INR75_13500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INR75_13515	COG4771	TonB-dependent receptor
INR75_13540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INR75_13545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INR75_13555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INR75_13580	COG0702	epimerase
INR75_13585	COG3534	alpha-L-arabinofuranosidase
INR75_13590	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_13605	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_13610	COG3940	Belongs to the glycosyl hydrolase 43 family
INR75_13620	COG0235	Class ii aldolase
INR75_13625	COG2160	L-arabinose isomerase activity
INR75_13695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INR75_13730	COG4206	TonB-dependent receptor
INR75_13730	COG1629	transport
INR75_13745	COG2076	Multidrug Resistance protein
INR75_13750	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_13755	COG2205	protein histidine kinase activity
INR75_13755	COG3292	Two component regulator propeller
INR75_13755	COG0745	RESPONSE REGULATOR receiver
INR75_13760	COG4771	TonB-dependent receptor
INR75_13765	COG0702	epimerase
INR75_13775	COG3250	beta-galactosidase activity
INR75_13785	COG1501	Belongs to the glycosyl hydrolase 31 family
INR75_13790	COG1082	Xylose isomerase domain protein TIM barrel
INR75_13795	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_13800	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_13810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INR75_13820	COG1482	cell wall glycoprotein biosynthetic process
INR75_13855	COG2311	Membrane
INR75_13875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_13920	COG0006	proline dipeptidase activity
INR75_13925	COG3250	beta-galactosidase activity
INR75_13930	COG0823	Involved in the tonB-independent uptake of proteins
INR75_13930	COG1506	peptidase
INR75_13940	COG4948	Mandelate Racemase Muconate Lactonizing
INR75_13945	COG4771	TonB-dependent receptor
INR75_13955	COG1629	transport
INR75_13975	COG1917	Cupin 2, conserved barrel domain protein
INR75_13975	COG4977	sequence-specific DNA binding
INR75_13980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INR75_13990	COG3938	Belongs to the proline racemase family
INR75_14000	COG0823	Involved in the tonB-independent uptake of proteins
INR75_14000	COG1506	peptidase
INR75_14015	COG3534	alpha-L-arabinofuranosidase
INR75_14070	COG2826	transposase and inactivated derivatives, IS30 family
INR75_14085	COG2826	transposase and inactivated derivatives, IS30 family
INR75_14130	COG2826	transposase and inactivated derivatives, IS30 family
INR75_14145	COG2826	transposase and inactivated derivatives, IS30 family
INR75_14160	COG2826	transposase and inactivated derivatives, IS30 family
INR75_14200	COG2826	transposase and inactivated derivatives, IS30 family
INR75_14215	COG4974	Belongs to the 'phage' integrase family
INR75_14220	COG1473	amidohydrolase
INR75_14230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INR75_14260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
INR75_14270	COG1764	response to oxidative stress
INR75_14275	COG1047	Peptidyl-prolyl cis-trans
INR75_14280	COG0673	inositol 2-dehydrogenase activity
INR75_14305	COG0527	aspartate kinase activity
INR75_14320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INR75_14325	COG3265	gluconokinase activity
INR75_14330	COG2610	gluconate transmembrane transporter activity
INR75_14340	COG0217	transcriptional regulatory protein
INR75_14345	COG2154	pterin-4-alpha-carbinolamine dehydratase
INR75_14355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INR75_14360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INR75_14360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INR75_14365	COG2986	histidine ammonia-lyase
INR75_14375	COG0542	response to heat
INR75_14380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INR75_14395	COG0183	Belongs to the thiolase family
INR75_14425	COG1012	belongs to the aldehyde dehydrogenase family
INR75_14440	COG1607	acyl-coa hydrolase
INR75_14445	COG0668	transmembrane transport
INR75_14455	COG0668	transmembrane transport
INR75_14460	COG2814	Major facilitator Superfamily
INR75_14490	COG4221	oxidoreductase activity
INR75_14505	COG4221	oxidoreductase activity
INR75_14510	COG2130	NADP-dependent
INR75_14515	COG1289	transmembrane transporter activity
INR75_14535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INR75_14545	COG1902	pentaerythritol trinitrate reductase activity
INR75_14555	COG0604	alcohol dehydrogenase
INR75_14575	COG0583	DNA-binding transcription factor activity
INR75_14580	COG2855	membrane
INR75_14585	COG0698	ribose 5-phosphate isomerase
INR75_14590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INR75_14595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INR75_14600	COG0363	glucosamine-6-phosphate deaminase activity
INR75_14610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INR75_14615	COG3384	dioxygenase
INR75_14625	COG2723	6-phospho-beta-galactosidase activity
INR75_14640	COG1629	transport
INR75_14700	COG0022	dehydrogenase e1 component
INR75_14710	COG0023	Translation Initiation Factor
INR75_14720	COG0813	purine-nucleoside phosphorylase activity
INR75_14725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INR75_14730	COG1054	Belongs to the UPF0176 family
INR75_14740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INR75_14750	COG3011	Protein conserved in bacteria
INR75_14765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INR75_14790	COG0778	Nitroreductase
INR75_14805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INR75_14815	COG0693	protein deglycase activity
INR75_14820	COG1295	ribonuclease BN
INR75_14830	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
INR75_14835	COG1522	sequence-specific DNA binding
INR75_14860	COG1970	mechanosensitive ion channel activity
INR75_14880	COG0012	GTP binding
INR75_14890	COG2226	methyltransferase
INR75_14900	COG3537	Alpha-1,2-mannosidase
INR75_14905	COG3537	Alpha-1,2-mannosidase
INR75_14935	COG0247	lactate metabolic process
INR75_14945	COG0438	transferase activity, transferring glycosyl groups
INR75_14950	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_14960	COG0247	lactate metabolic process
INR75_14960	COG2181	nitrate reductase activity
INR75_14965	COG0247	lactate metabolic process
INR75_14965	COG2181	nitrate reductase activity
INR75_14975	COG0860	N-Acetylmuramoyl-L-alanine amidase
INR75_14985	COG0251	oxidation-reduction process
INR75_14990	COG0667	Aldo Keto reductase
INR75_15000	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
INR75_15010	COG1803	Methylglyoxal synthase
INR75_15015	COG0205	6-phosphofructokinase activity
INR75_15025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INR75_15040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INR75_15080	COG1215	transferase activity, transferring glycosyl groups
INR75_15085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INR75_15090	COG0038	chloride channel
INR75_15100	COG0726	polysaccharide deacetylase
INR75_15110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INR75_15135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INR75_15145	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_15170	COG4974	Belongs to the 'phage' integrase family
INR75_15245	COG0805	protein transport
INR75_15250	COG2963	transposase activity
INR75_15260	COG0681	Belongs to the peptidase S26 family
INR75_15265	COG3279	Response regulator of the LytR AlgR family
INR75_15270	COG3275	phosphorelay sensor kinase activity
INR75_15280	COG5002	protein histidine kinase activity
INR75_15285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INR75_15325	COG0124	histidyl-tRNA synthetase
INR75_15330	COG0577	efflux transmembrane transporter activity
INR75_15345	COG0359	binds to the 23S rRNA
INR75_15350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INR75_15355	COG0360	Binds together with S18 to 16S ribosomal RNA
INR75_15360	COG3279	Response regulator of the LytR AlgR family
INR75_15365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INR75_15380	COG1295	ribonuclease BN
INR75_15390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INR75_15395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INR75_15420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INR75_15435	COG0670	Belongs to the BI1 family
INR75_15440	COG1091	dTDP-4-dehydrorhamnose reductase activity
INR75_15490	COG1842	Phage shock protein A
INR75_15520	COG0589	response to stress
INR75_15525	COG0069	glutamate synthase activity
INR75_15530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INR75_15540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INR75_15590	COG1045	serine acetyltransferase
INR75_15600	COG2936	dipeptidyl-peptidase activity
INR75_15610	COG4771	TonB-dependent receptor
INR75_15665	COG4206	TonB-dependent receptor
INR75_15675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INR75_15680	COG1120	ATPase activity
INR75_15700	COG1607	acyl-coa hydrolase
INR75_15715	COG2363	Small membrane protein
INR75_15725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INR75_15750	COG1741	Belongs to the pirin family
INR75_15760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INR75_15785	COG0254	rRNA binding
INR75_15795	COG0463	Glycosyl transferase, family 2
INR75_15800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INR75_15805	COG1132	(ABC) transporter
INR75_15830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INR75_15830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INR75_15835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INR75_15835	COG0047	phosphoribosylformylglycinamidine synthase activity
INR75_15850	COG1022	Amp-dependent synthetase and ligase
INR75_15855	COG1846	Transcriptional regulator
INR75_15860	COG1250	3-hydroxyacyl-CoA dehydrogenase
INR75_15860	COG1024	Enoyl-CoA hydratase
INR75_15870	COG0183	Belongs to the thiolase family
INR75_15875	COG1960	acyl-CoA dehydrogenase activity
INR75_15895	COG3387	PFAM Glycoside hydrolase 15-related
INR75_15930	COG2183	response to ionizing radiation
INR75_15945	COG4771	TonB-dependent receptor
INR75_15950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INR75_15990	COG2211	Major facilitator Superfamily
INR75_15995	COG0673	inositol 2-dehydrogenase activity
INR75_16015	COG1595	DNA-templated transcription, initiation
INR75_16025	COG3279	Response regulator of the LytR AlgR family
INR75_16035	COG3275	phosphorelay sensor kinase activity
INR75_16045	COG4206	TonB-dependent receptor
INR75_16045	COG1629	transport
INR75_16070	COG0494	nUDIX hydrolase
INR75_16075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INR75_16105	COG0714	Associated with various cellular activities
INR75_16170	COG0492	ferredoxin-NADP+ reductase activity
INR75_16175	COG2860	membrane
INR75_16195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INR75_16200	COG0439	Biotin carboxylase
INR75_16210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_16250	COG1476	TRANSCRIPTIONal
INR75_16255	COG3940	Belongs to the glycosyl hydrolase 43 family
INR75_16265	COG1271	oxidase subunit
INR75_16270	COG0730	response to heat
INR75_16290	COG1733	regulation of RNA biosynthetic process
INR75_16305	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
INR75_16310	COG0352	thiamine-phosphate diphosphorylase activity
INR75_16315	COG0351	phosphomethylpyrimidine kinase
INR75_16320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
INR75_16330	COG2207	Transcriptional regulator
INR75_16345	COG1785	Belongs to the alkaline phosphatase family
INR75_16350	COG1785	Belongs to the alkaline phosphatase family
INR75_16360	COG4206	TonB-dependent receptor
INR75_16360	COG1629	transport
INR75_16395	COG3279	Response regulator of the LytR AlgR family
INR75_16425	COG0714	Associated with various cellular activities
INR75_16435	COG0312	modulator of DNA gyrase
INR75_16440	COG0312	modulator of DNA gyrase
INR75_16490	COG0348	domain, Protein
INR75_16505	COG3278	Belongs to the heme-copper respiratory oxidase family
INR75_16515	COG2217	Heavy metal translocating P-type atpase
INR75_16545	COG4999	Histidine kinase
INR75_16545	COG3850	Histidine kinase
INR75_16545	COG3437	response regulator, receiver
INR75_16545	COG2205	protein histidine kinase activity
INR75_16550	COG2116	formate transmembrane transporter activity
INR75_16555	COG2084	Dehydrogenase
INR75_16570	COG0339	signal peptide processing
INR75_16585	COG1187	pseudouridine synthase activity
INR75_16595	COG0405	Gamma-glutamyltransferase
INR75_16610	COG4251	negative regulation of phosphorylation
INR75_16620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INR75_16625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INR75_16630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INR75_16640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INR75_16640	COG4651	solute:proton antiporter activity
INR75_16670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INR75_16675	COG0083	homoserine kinase activity
INR75_16680	COG0460	homoserine dehydrogenase
INR75_16680	COG0527	aspartate kinase activity
INR75_16700	COG3437	response regulator, receiver
INR75_16720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INR75_16725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INR75_16730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INR75_16735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_16750	COG0783	Belongs to the Dps family
INR75_16755	COG0668	transmembrane transport
INR75_16785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_16810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INR75_16820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INR75_16825	COG1611	Belongs to the LOG family
INR75_16835	COG0022	dehydrogenase e1 component
INR75_16890	COG2996	Protein conserved in bacteria
INR75_16900	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INR75_16930	COG0443	Heat shock 70 kDa protein
INR75_16935	COG1760	l-serine dehydratase
INR75_16955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INR75_16975	COG3387	PFAM Glycoside hydrolase 15-related
INR75_16990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INR75_16995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INR75_17000	COG0066	3-isopropylmalate dehydratase activity
INR75_17005	COG0473	3-isopropylmalate dehydrogenase activity
INR75_17015	COG0165	Argininosuccinate lyase
INR75_17020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INR75_17025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INR75_17035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INR75_17040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INR75_17045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INR75_17050	COG0137	argininosuccinate synthase activity
INR75_17060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INR75_17065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INR75_17075	COG0028	Belongs to the TPP enzyme family
INR75_17085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INR75_17085	COG3153	acetyltransferase
INR75_17095	COG4585	Histidine kinase
INR75_17115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
INR75_17120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
INR75_17125	COG1914	H( )-stimulated, divalent metal cation uptake system
INR75_17180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INR75_17185	COG0205	6-phosphofructokinase activity
INR75_17190	COG0366	Alpha amylase catalytic
INR75_17195	COG0366	Alpha amylase catalytic
INR75_17200	COG1082	Xylose isomerase domain protein TIM barrel
INR75_17205	COG1554	hydrolase, family 65, central catalytic
INR75_17210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INR75_17225	COG4206	TonB-dependent receptor
INR75_17225	COG1629	transport
INR75_17230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INR75_17240	COG0366	Alpha amylase catalytic
INR75_17270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INR75_17275	COG1085	galactose-1-phosphate uridylyltransferase
INR75_17300	COG4232	protein-disulfide reductase activity
INR75_17305	COG0037	tRNA processing
INR75_17310	COG3549	Plasmid maintenance system killer
INR75_17320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INR75_17350	COG3279	Response regulator of the LytR AlgR family
INR75_17370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_17375	COG1757	Na H antiporter
INR75_17380	COG0450	alkyl hydroperoxide reductase
INR75_17410	COG1674	ftsk spoiiie
INR75_17425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INR75_17425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INR75_17450	COG4771	TonB-dependent receptor
INR75_17455	COG0561	phosphatase activity
INR75_17475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INR75_17480	COG0420	3'-5' exonuclease activity
INR75_17485	COG0419	ATPase involved in DNA repair
INR75_17495	COG1272	protein, Hemolysin III
INR75_17500	COG2197	response regulator
INR75_17565	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
INR75_17645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_17675	COG0386	Belongs to the glutathione peroxidase family
INR75_17685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_17700	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_17730	COG0242	peptide deformylase activity
INR75_17760	COG4974	Belongs to the 'phage' integrase family
INR75_17770	COG1012	belongs to the aldehyde dehydrogenase family
INR75_17775	COG0656	L-ascorbic acid biosynthetic process
INR75_17795	COG1368	sulfuric ester hydrolase activity
INR75_17810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INR75_17825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INR75_17840	COG0154	amidase activity
INR75_17845	COG0552	protein localization to endoplasmic reticulum
INR75_17855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INR75_17860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INR75_17865	COG1058	Belongs to the CinA family
INR75_17865	COG1546	Belongs to the CinA family
INR75_17875	COG0179	Fumarylacetoacetate (FAA) hydrolase
INR75_17885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
INR75_17890	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_17895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INR75_17915	COG0488	(ABC) transporter
INR75_17925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INR75_17930	COG0300	oxidoreductase activity
INR75_17965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INR75_17980	COG3118	belongs to the thioredoxin family
INR75_17985	COG0542	response to heat
INR75_18005	COG1012	belongs to the aldehyde dehydrogenase family
INR75_18015	COG4106	trans-aconitate 2-methyltransferase activity
INR75_18025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INR75_18040	COG0242	peptide deformylase activity
INR75_18045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INR75_18050	COG2171	N-acyltransferase activity
INR75_18080	COG0009	L-threonylcarbamoyladenylate synthase
INR75_18085	COG0517	IMP dehydrogenase activity
INR75_18085	COG0617	tRNA 3'-terminal CCA addition
INR75_18085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INR75_18125	COG0556	nucleotide-excision repair
INR75_18135	COG2204	response regulator
INR75_18145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
INR75_18145	COG3264	Mechanosensitive ion channel
INR75_18150	COG1668	transmembrane transport
INR75_18155	COG4152	abc transporter atp-binding protein
INR75_18165	COG0484	heat shock protein binding
INR75_18170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INR75_18185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INR75_18185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
INR75_18195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INR75_18215	COG0347	Belongs to the P(II) protein family
INR75_18220	COG0004	ammonium transporteR
INR75_18245	COG2226	methyltransferase
INR75_18250	COG1522	sequence-specific DNA binding
INR75_18260	COG2095	MarC family integral membrane protein
INR75_18265	COG1703	isobutyryl-CoA mutase activity
INR75_18265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_18265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_18270	COG0788	formyltetrahydrofolate deformylase activity
INR75_18275	COG0753	catalase activity
INR75_18290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INR75_18295	COG0284	orotidine-5'-phosphate decarboxylase activity
INR75_18300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INR75_18305	COG1131	(ABC) transporter
INR75_18315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INR75_18325	COG0174	glutamine synthetase
INR75_18350	COG4206	TonB-dependent receptor
INR75_18350	COG1629	transport
INR75_18360	COG2814	Major facilitator Superfamily
INR75_18365	COG2885	chlorophyll binding
INR75_18400	COG1994	Peptidase M50
INR75_18425	COG0604	alcohol dehydrogenase
INR75_18450	COG3250	beta-galactosidase activity
INR75_18460	COG0702	epimerase
INR75_18465	COG1629	transport
INR75_18465	COG4206	TonB-dependent receptor
INR75_18470	COG0745	RESPONSE REGULATOR receiver
INR75_18470	COG3292	Two component regulator propeller
INR75_18470	COG2205	protein histidine kinase activity
INR75_18475	COG2205	protein histidine kinase activity
INR75_18475	COG0745	RESPONSE REGULATOR receiver
INR75_18475	COG3292	Two component regulator propeller
INR75_18480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INR75_18485	COG1621	beta-fructofuranosidase activity
INR75_18500	COG1621	beta-fructofuranosidase activity
INR75_18510	COG4771	TonB-dependent receptor
INR75_18515	COG1621	beta-fructofuranosidase activity
INR75_18520	COG2814	Major facilitator Superfamily
INR75_18525	COG3292	Two component regulator propeller
INR75_18525	COG2205	protein histidine kinase activity
INR75_18525	COG0745	RESPONSE REGULATOR receiver
INR75_18530	COG0629	single-stranded DNA binding
INR75_18535	COG2003	Belongs to the UPF0758 family
INR75_18545	COG2076	Multidrug Resistance protein
INR75_18555	COG3852	Histidine kinase
INR75_18565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INR75_18590	COG1629	transport
INR75_18600	COG3279	Response regulator of the LytR AlgR family
INR75_18615	COG2201	protein-glutamate methylesterase activity
INR75_18625	COG0629	single-stranded DNA binding
INR75_18630	COG2003	Belongs to the UPF0758 family
INR75_18730	COG0156	8-amino-7-oxononanoate synthase activity
INR75_18755	COG2304	oxidoreductase activity
INR75_18820	COG2264	protein methyltransferase activity
INR75_18825	COG0149	triose-phosphate isomerase activity
INR75_18840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INR75_18845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INR75_18855	COG1132	(ABC) transporter
INR75_18860	COG0101	tRNA pseudouridine synthase activity
INR75_18880	COG0745	RESPONSE REGULATOR receiver
INR75_18885	COG5002	protein histidine kinase activity
INR75_18905	COG0740	serine-type endopeptidase activity
INR75_18920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INR75_18945	COG2226	methyltransferase
INR75_18950	COG1477	protein flavinylation
INR75_18965	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INR75_18970	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INR75_18980	COG1805	sodium ion transport
INR75_18985	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INR75_19010	COG1012	belongs to the aldehyde dehydrogenase family
INR75_19020	COG0357	Ribosomal RNA small subunit methyltransferase G
INR75_19025	COG3239	Fatty acid desaturase
INR75_19030	COG0436	Aminotransferase
INR75_19035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INR75_19040	COG0569	domain protein
INR75_19045	COG2226	methyltransferase
INR75_19065	COG0191	fructose-bisphosphate aldolase activity
INR75_19070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
INR75_19075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INR75_19080	COG1185	polyribonucleotide nucleotidyltransferase activity
INR75_19090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INR75_19100	COG0095	Lipoate-protein ligase
INR75_19105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INR75_19110	COG0492	ferredoxin-NADP+ reductase activity
INR75_19125	COG2814	Major facilitator Superfamily
INR75_19125	COG0477	Major facilitator Superfamily
INR75_19165	COG3250	beta-galactosidase activity
INR75_19170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_19195	COG0702	epimerase
INR75_19200	COG4771	TonB-dependent receptor
INR75_19205	COG2205	protein histidine kinase activity
INR75_19205	COG0745	RESPONSE REGULATOR receiver
INR75_19205	COG0745	RESPONSE REGULATOR receiver
INR75_19205	COG3292	Two component regulator propeller
INR75_19205	COG3292	Two component regulator propeller
INR75_19205	COG2205	protein histidine kinase activity
INR75_19210	COG4677	pectinesterase activity
INR75_19215	COG0432	Pfam Uncharacterised protein family UPF0047
INR75_19225	COG0305	Participates in initiation and elongation during chromosome replication
INR75_19230	COG0825	malonyl-CoA metabolic process
INR75_19240	COG0343	queuine tRNA-ribosyltransferase activity
INR75_19245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
INR75_19250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INR75_19265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INR75_19270	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INR75_19275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INR75_19300	COG0789	Transcriptional regulator
INR75_19305	COG1233	COG1233 Phytoene dehydrogenase and related
INR75_19325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_19330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INR75_19335	COG0714	Associated with various cellular activities
INR75_19340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INR75_19355	COG0517	IMP dehydrogenase activity
INR75_19355	COG0516	GMP reductase activity
INR75_19375	COG0167	dihydroorotate dehydrogenase activity
INR75_19380	COG2195	Cleaves the N-terminal amino acid of tripeptides
INR75_19400	COG1862	Preprotein translocase
INR75_19410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INR75_19420	COG1132	(ABC) transporter
INR75_19435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INR75_19440	COG0569	domain protein
INR75_19450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INR75_19460	COG0450	alkyl hydroperoxide reductase
INR75_19465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INR75_19470	COG1228	amidohydrolase
INR75_19490	COG2884	Cell division ATP-binding protein ftsE
INR75_19500	COG1858	cytochrome C peroxidase
INR75_19525	COG1217	gtp-binding protein TYPA
INR75_19535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INR75_19540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_19650	COG3590	peptidase
INR75_19770	COG2197	response regulator
INR75_19775	COG4585	Histidine kinase
INR75_19805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INR75_19880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
INR75_19925	COG2003	Belongs to the UPF0758 family
INR75_19930	COG0629	single-stranded DNA binding
INR75_19935	COG0783	Belongs to the Dps family
INR75_19945	COG0450	alkyl hydroperoxide reductase
INR75_19975	COG0737	Belongs to the 5'-nucleotidase family
INR75_19990	COG1271	oxidase subunit
INR75_20015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_20050	COG2814	Major facilitator Superfamily
INR75_20060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INR75_20060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_20065	COG0730	response to heat
INR75_20100	COG1216	Glycosyl transferase, family 2
INR75_20100	COG1442	glycosyl transferase family 8
INR75_20105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_20110	COG0110	maltose O-acetyltransferase activity
INR75_20130	COG0438	transferase activity, transferring glycosyl groups
INR75_20155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INR75_20160	COG1216	Glycosyl transferase, family 2
INR75_20195	COG0784	Response regulator, receiver
INR75_20205	COG4251	negative regulation of phosphorylation
INR75_20215	COG4251	negative regulation of phosphorylation
INR75_20225	COG3279	Response regulator of the LytR AlgR family
INR75_20230	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_20235	COG0657	acetylesterase activity
INR75_20235	COG2755	lipolytic protein G-D-S-L family
INR75_20250	COG0431	NADPH-dependent FMN reductase
INR75_20275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
INR75_20285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INR75_20290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INR75_20295	COG1611	Belongs to the LOG family
INR75_20300	COG2890	protein-(glutamine-N5) methyltransferase activity
INR75_20310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INR75_20310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INR75_20315	COG1011	Hydrolase
INR75_20320	COG1739	Uncharacterized protein family UPF0029
INR75_20325	COG0824	Thioesterase