locus-tag	class	description
HG535_0A00130	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
HG535_0A00160	ENOG4108IQI	permease
HG535_0A00170	ENOG4107QK5	Homocysteine s-methyltransferase
HG535_0A00310	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG535_0A00480	ENOG4105K63	Thioredoxin
HG535_0A00590	ENOG4105E0X	reductase
HG535_0A00640	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HG535_0A00680	ENOG4108IQI	permease
HG535_0A00700	ENOG4105D9P	serine threonine protein kinase
HG535_0A00840	ENOG4105BZ1	(ABC) transporter
HG535_0A00850	ENOG4105DWV	Homoserine O-trans-acetylase
HG535_0A00920	ENOG4108JQ1	Dehydrogenase
HG535_0A00960	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HG535_0A01010	ENOG4108IQI	permease
HG535_0A01020	ENOG4108IQI	permease
HG535_0A01100	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0A01280	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG535_0A01300	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0A01320	ENOG4105C8N	cysteinyl-tRNA synthetase
HG535_0A01550	ENOG4108RVA	ribokinase
HG535_0A01570	ENOG4105C8P	)-transporter
HG535_0A01580	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG535_0A01650	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG535_0A01840	ENOG4105C85	amino acid
HG535_0A01930	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
HG535_0A02000	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HG535_0A02050	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HG535_0A02120	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HG535_0A02160	ENOG4105C0D	helicase
HG535_0A02210	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HG535_0A02270	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HG535_0A02450	ENOG4105D9P	serine threonine protein kinase
HG535_0A02640	ENOG41082NX	50s ribosomal protein l35
HG535_0A02710	ENOG4107QP3	malate synthase g
HG535_0A02920	ENOG4105CQ2	DNA polymerase
HG535_0A03050	ENOG4105E66	phosphoriboisomerase A
HG535_0A03090	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HG535_0A03120	ENOG4105DFA	alanine racemase domain protein
HG535_0A03170	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HG535_0A03250	ENOG4105CKU	formyltetrahydrofolate synthetase
HG535_0A03320	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HG535_0A03350	ENOG4105EUF	amidase EC 3.5.1.4
HG535_0A03430	ENOG4105IIU	Aminopeptidase
HG535_0A03440	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HG535_0A03460	ENOG4105C0D	helicase
HG535_0A03500	ENOG4105CP7	Triose-phosphate isomerase
HG535_0A03540	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HG535_0A03600	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HG535_0A03610	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG535_0A03630	ENOG4105CRK	lysyL-tRNA synthetase
HG535_0A03650	ENOG4105D9P	serine threonine protein kinase
HG535_0A03670	ENOG41060WC	Enoyl-CoA hydratase
HG535_0A03700	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HG535_0A03810	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG535_0A03820	ENOG4105C1J	atp-dependent rna helicase
HG535_0A03840	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HG535_0A03860	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HG535_0A03900	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HG535_0A03940	ENOG4105C5I	Dehydrogenase
HG535_0A03960	ENOG41066UZ	arginase EC 3.5.3.1
HG535_0A03990	ENOG4105C1J	atp-dependent rna helicase
HG535_0A04010	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0A04100	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG535_0A04300	ENOG4105C26	Dehydrogenase
HG535_0A04310	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HG535_0A04320	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HG535_0A04370	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG535_0A04380	ENOG4108I5C	dEAD DEAH box helicase
HG535_0A04410	ENOG4108PBA	serine threonine protein kinase
HG535_0A04450	ENOG4105ECY	inositol monophosphatase
HG535_0A04470	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG535_0A04540	ENOG4105ECY	inositol monophosphatase
HG535_0A04580	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HG535_0A04640	ENOG4107QMU	Mate efflux family protein
HG535_0A04650	ENOG4107QUV	Domain protein
HG535_0A04660	ENOG4105D9P	serine threonine protein kinase
HG535_0A04710	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HG535_0A04720	ENOG4105C1V	Peptidase, M16
HG535_0A04840	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG535_0A04850	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HG535_0A04900	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0A05000	ENOG4105C1J	atp-dependent rna helicase
HG535_0A05020	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0A05030	ENOG4108Z6B	deaminase
HG535_0A05070	ENOG4107Z6I	Thiamine biosynthesis protein
HG535_0A05130	ENOG4108MGY	Histidine kinase
HG535_0A05270	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG535_0A05350	ENOG4105C1J	atp-dependent rna helicase
HG535_0A05390	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
HG535_0A05520	ENOG4105C31	Tryptophanyl-tRNA synthetase
HG535_0A05620	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0A05670	ENOG4107QP8	phosphohexose isomerase
HG535_0A05800	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HG535_0A05860	ENOG4105C1J	atp-dependent rna helicase
HG535_0A05870	ENOG4105D9P	serine threonine protein kinase
HG535_0A05880	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG535_0A05890	ENOG4108UGD	Serine Threonine protein kinase
HG535_0A05930	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HG535_0A05970	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HG535_0A06000	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HG535_0A06060	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HG535_0A06080	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HG535_0A06180	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG535_0A06190	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HG535_0A06230	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG535_0A06260	ENOG4105KHC	sulfurtransferase
HG535_0A06280	ENOG4105CQ2	DNA polymerase
HG535_0A06320	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0A06370	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HG535_0A06410	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0A06430	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HG535_0A06550	ENOG4105C2C	drug resistance transporter, Bcr CflA
HG535_0A06580	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HG535_0A06630	ENOG4107QPV	Serine Threonine protein kinase
HG535_0A06680	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HG535_0A06750	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HG535_0A06770	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG535_0A06780	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HG535_0A06810	ENOG4105KDC	50s ribosomal protein l28
HG535_0A07040	ENOG4107XDR	Lactoylglutathione lyase
HG535_0A07050	ENOG4105CQ7	ATP-dependent helicase
HG535_0A07110	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HG535_0A07140	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HG535_0A07240	ENOG4105D98	threonine synthase
HG535_0A07370	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HG535_0A07410	ENOG4105CKI	cobalamin synthesis protein
HG535_0A07570	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HG535_0A07590	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HG535_0A07600	ENOG4105C1J	atp-dependent rna helicase
HG535_0A07640	ENOG4105K63	Thioredoxin
HG535_0A07670	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HG535_0A07690	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG535_0A07760	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HG535_0A07850	ENOG4105IDI	abc transporter atp-binding protein
HG535_0A07870	ENOG4105M2J	Glutaredoxin
HG535_0A07930	ENOG4105C26	Dehydrogenase
HG535_0A07940	ENOG4105C26	Dehydrogenase
HG535_0A07980	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HG535_0A08050	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HG535_0A08150	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HG535_0A08250	ENOG4107QPV	Serine Threonine protein kinase
HG535_0A08310	ENOG4105C3G	gtp-binding protein
HG535_0A08340	ENOG4108IQI	permease
HG535_0A08470	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0A08710	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HG535_0A08730	ENOG4105D3R	alkyl hydroperoxide reductase
HG535_0A08740	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HG535_0A08790	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG535_0A08810	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0A08820	ENOG4105DGU	Histone deacetylase
HG535_0A08900	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HG535_0A08910	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HG535_0A08930	ENOG4105D94	Major Facilitator Superfamily
HG535_0A08970	ENOG4105EX0	alpha-galactosidase
HG535_0A08980	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HG535_0A09000	ENOG4105CJ3	phosphate transporter
HG535_0A09020	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HG535_0A09030	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HG535_0A09040	ENOG4105DEI	Mannitol dehydrogenase
HG535_0A09070	ENOG4105CPC	Aldo Keto reductase
HG535_0A09080	ENOG4107SET	aldo keto reductase
HG535_0A09120	ENOG4107QNK	)-transporter
HG535_0A09130	ENOG4105CK7	Sodium proline symporter
HG535_0A09160	ENOG4107RB3	L-asparaginase
HG535_0B00110	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG535_0B00150	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG535_0B00170	ENOG4105IDI	abc transporter atp-binding protein
HG535_0B00180	ENOG4105CV8	reductase
HG535_0B00270	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HG535_0B00280	ENOG41079KZ	Major Facilitator Superfamily
HG535_0B00330	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HG535_0B00350	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HG535_0B00370	ENOG4107RIQ	Sulfate adenylate transferase
HG535_0B00450	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HG535_0B00510	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HG535_0B00570	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HG535_0B00580	ENOG4105CKU	formyltetrahydrofolate synthetase
HG535_0B00590	ENOG4105C29	acyl-CoA thioesterase
HG535_0B00640	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
HG535_0B00660	ENOG4105TPV	
HG535_0B00670	ENOG4105EAC	phosphoserine phosphatase
HG535_0B00700	ENOG4107RA9	decarboxylase
HG535_0B00710	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0B00810	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HG535_0B00820	ENOG4105D9P	serine threonine protein kinase
HG535_0B00830	ENOG4105D9P	serine threonine protein kinase
HG535_0B00840	ENOG4105E09	nadh pyrophosphatase
HG535_0B00850	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HG535_0B00920	ENOG4105C1J	atp-dependent rna helicase
HG535_0B01000	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HG535_0B01070	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HG535_0B01110	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HG535_0B01120	ENOG4105CNG	UPF0061 protein
HG535_0B01170	ENOG41076HS	cation diffusion facilitator family transporter
HG535_0B01190	ENOG4105CEV	competence damage-inducible protein
HG535_0B01200	ENOG4105C5H	ABC transporter
HG535_0B01220	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HG535_0B01270	ENOG4105DKW	ABC transporter
HG535_0B01280	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG535_0B01340	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HG535_0B01420	ENOG4105EKT	)-iron permease
HG535_0B01450	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HG535_0B01540	ENOG4105C1J	atp-dependent rna helicase
HG535_0B01590	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG535_0B01610	ENOG4107QNK	)-transporter
HG535_0B01640	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HG535_0B01660	ENOG4108V06	Glutathione peroxidase
HG535_0B01670	ENOG4105C0D	helicase
HG535_0B01690	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HG535_0B01750	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HG535_0B01760	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HG535_0B01770	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HG535_0B01820	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0B01840	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HG535_0B01960	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG535_0B02010	ENOG4105K63	Thioredoxin
HG535_0B02020	ENOG4105BZU	Histidine kinase
HG535_0B02100	ENOG4105CAQ	asparagine synthetase
HG535_0B02110	ENOG4105CHH	sulfate transporter
HG535_0B02260	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG535_0B02290	ENOG4107QNK	)-transporter
HG535_0B02350	ENOG4105C2X	Arabinose 5-phosphate isomerase
HG535_0B02390	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HG535_0B02410	ENOG4107SQD	Transcriptional regulator, GntR family
HG535_0B02430	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HG535_0B02610	ENOG4105EGD	dinuclear metal center protein, YbgI family
HG535_0B02640	ENOG4105C5H	ABC transporter
HG535_0B02720	ENOG4105C0D	helicase
HG535_0B02730	ENOG4105FDK	ABC transporter
HG535_0B02980	ENOG4105CHM	Aminotransferase
HG535_0B03150	ENOG4105CQ7	ATP-dependent helicase
HG535_0B03170	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HG535_0B03240	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HG535_0B03260	ENOG4105SYT	Methylenetetrahydrofolate reductase
HG535_0B03280	ENOG4105CEY	Amp-dependent synthetase and ligase
HG535_0B03290	ENOG4105CPP	Dehydrogenase, E1 component
HG535_0B03410	ENOG4105C1J	atp-dependent rna helicase
HG535_0B03520	ENOG4105C2W	permease
HG535_0B03530	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG535_0B03550	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG535_0B03660	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HG535_0B03680	ENOG4105C0D	helicase
HG535_0B03790	ENOG4105CFN	oxalyl-CoA decarboxylase
HG535_0B03800	ENOG4105C5S	asparaginyl-tRNA synthetase
HG535_0B03870	ENOG4105CHR	reductase
HG535_0B03970	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HG535_0B04030	ENOG4105BZA	Phosphoglycerate kinase
HG535_0B04040	ENOG4105D5T	phosphonate abc transporter
HG535_0B04120	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HG535_0B04150	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HG535_0B04230	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HG535_0B04240	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0B04280	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG535_0B04360	ENOG4105K46	50S ribosomal protein l27
HG535_0B04400	ENOG4105CHW	UPF0052 protein
HG535_0B04430	ENOG4105C5H	ABC transporter
HG535_0B04530	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HG535_0B04540	ENOG4105C7B	Threonine dehydratase
HG535_0B04580	ENOG4105CQB	FAD linked oxidase domain protein
HG535_0B04640	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HG535_0B04650	ENOG4108V5V	Serine Threonine protein kinase
HG535_0B04680	ENOG4105D9P	serine threonine protein kinase
HG535_0B04710	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0B04780	ENOG4105CVJ	phosphoglycerate mutase
HG535_0B04800	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HG535_0B04900	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HG535_0B04950	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG535_0B05270	ENOG4107R5B	glutamine synthetase
HG535_0B05330	ENOG4105CUT	histidyl-tRNA synthetase
HG535_0B05370	ENOG4105D9P	serine threonine protein kinase
HG535_0B05660	ENOG4105D52	delta-aminolevulinic acid dehydratase
HG535_0B05700	ENOG4105VFU	Rna-binding protein
HG535_0B05750	ENOG4105VFU	Rna-binding protein
HG535_0B05840	ENOG4105D9P	serine threonine protein kinase
HG535_0B05970	ENOG4108QVN	serine threonine protein kinase
HG535_0B06000	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HG535_0B06030	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
HG535_0B06200	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HG535_0B06250	ENOG4105M2Z	protein tyrosine serine phosphatase
HG535_0B06280	ENOG4105C8T	Leucyl-tRNA synthetase
HG535_0B06380	ENOG4107VK2	coenzyme PQQ biosynthesis protein PqqF
HG535_0B06580	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HG535_0B06640	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HG535_0B06740	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG535_0B06760	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HG535_0B06870	ENOG4105CQ7	ATP-dependent helicase
HG535_0B06910	ENOG4105EKE	dihydroorotase
HG535_0B06930	ENOG4105CEV	competence damage-inducible protein
HG535_0B06950	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HG535_0B06970	ENOG4105C22	threonyL-tRNA synthetase
HG535_0B07030	ENOG4108IQI	permease
HG535_0B07080	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG535_0C00180	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HG535_0C00200	ENOG4105BZ1	(ABC) transporter
HG535_0C00220	ENOG4105K6H	D-cysteine desulfhydrase
HG535_0C00320	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HG535_0C00430	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG535_0C00480	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HG535_0C00510	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HG535_0C00520	ENOG4105II7	pyrroline-5-carboxylate reductase
HG535_0C00740	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HG535_0C00770	ENOG4105D9P	serine threonine protein kinase
HG535_0C00840	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HG535_0C00900	ENOG4105CPC	Aldo Keto reductase
HG535_0C00940	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HG535_0C00960	ENOG4105CQ7	ATP-dependent helicase
HG535_0C00970	ENOG4107QNK	)-transporter
HG535_0C00980	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HG535_0C01110	ENOG4108ZGC	gaf domain protein
HG535_0C01190	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HG535_0C01210	ENOG4105D9P	serine threonine protein kinase
HG535_0C01220	ENOG4105CHR	reductase
HG535_0C01270	ENOG4108IQI	permease
HG535_0C01340	ENOG4105G6Z	alkaline phosphatase
HG535_0C01380	ENOG4105CH6	catalase
HG535_0C01470	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG535_0C01570	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HG535_0C01580	ENOG4108QVN	serine threonine protein kinase
HG535_0C01620	ENOG4105SYT	Methylenetetrahydrofolate reductase
HG535_0C01670	ENOG4105C1J	atp-dependent rna helicase
HG535_0C01680	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0C01740	ENOG4107QI1	Mate efflux family protein
HG535_0C01770	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HG535_0C01850	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HG535_0C01870	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HG535_0C01900	ENOG4105DBI	uridine monophosphokinase
HG535_0C01920	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HG535_0C01950	ENOG4105CEY	Amp-dependent synthetase and ligase
HG535_0C01970	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HG535_0C02020	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HG535_0C02080	ENOG4105KNE	Phosphatidate cytidylyltransferase
HG535_0C02120	ENOG4105C3G	gtp-binding protein
HG535_0C02150	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
HG535_0C02180	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HG535_0C02190	ENOG4105IDI	abc transporter atp-binding protein
HG535_0C02230	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HG535_0C02330	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HG535_0C02370	ENOG4105C26	Dehydrogenase
HG535_0C02440	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HG535_0C02490	ENOG4105VW4	glutaredoxin 3
HG535_0C02540	ENOG4105D9P	serine threonine protein kinase
HG535_0C02590	ENOG4105C8V	SAICAR synthetase
HG535_0C02600	ENOG4105D9P	serine threonine protein kinase
HG535_0C02610	ENOG4105D9P	serine threonine protein kinase
HG535_0C02640	ENOG4105DWF	phosphomethylpyrimidine kinase
HG535_0C02670	ENOG4105CDH	Citrulline--aspartate ligase
HG535_0C02680	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HG535_0C02720	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG535_0C02780	ENOG4105C1J	atp-dependent rna helicase
HG535_0C02800	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HG535_0C02830	ENOG4105EI2	Pseudouridine synthase
HG535_0C02860	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG535_0C02940	ENOG4105Y75	tpr repeat protein
HG535_0C03060	ENOG4105IDI	abc transporter atp-binding protein
HG535_0C03070	ENOG41090KN	UPF0303 protein
HG535_0C03190	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HG535_0C03560	ENOG4105D9P	serine threonine protein kinase
HG535_0C03630	ENOG4105C0D	helicase
HG535_0C03670	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HG535_0C03690	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HG535_0C03700	ENOG4105DWV	Homoserine O-trans-acetylase
HG535_0C03710	ENOG4107QI1	Mate efflux family protein
HG535_0C03760	ENOG4107QNK	)-transporter
HG535_0C03770	ENOG4107QNK	)-transporter
HG535_0C03780	ENOG4105C54	Major Facilitator superfamily
HG535_0C03940	ENOG4105C3M	thioredoxin reductase
HG535_0C03960	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HG535_0C04040	ENOG4105D06	uba thif-type nad fad binding protein
HG535_0C04060	ENOG4105C28	cystathionine
HG535_0C04070	ENOG4105DFM	M18 family aminopeptidase
HG535_0C04090	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG535_0C04170	ENOG4105CV8	reductase
HG535_0C04310	ENOG4105JD4	ATPase yjob
HG535_0C04330	ENOG4105EQH	reductase
HG535_0C04380	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HG535_0C04390	ENOG4107RA9	decarboxylase
HG535_0C04450	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HG535_0C04460	ENOG4105C5H	ABC transporter
HG535_0C04480	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HG535_0C04570	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HG535_0C04580	ENOG4105C5S	asparaginyl-tRNA synthetase
HG535_0C04590	ENOG4105CH7	arginosuccinase
HG535_0C04630	ENOG4105CEP	NADH dehydrogenase
HG535_0C04760	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HG535_0C04770	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG535_0C04840	ENOG4105CQR	helicase
HG535_0C04870	ENOG4108URH	decarboxylase
HG535_0C04930	ENOG4105CHM	Aminotransferase
HG535_0C05010	ENOG4108ZT0	50S ribosomal protein l17
HG535_0C05020	ENOG4105C6T	cysteine synthase
HG535_0C05240	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG535_0C05290	ENOG4105DJ4	phosphatidylserine decarboxylase
HG535_0C05340	ENOG4105D2N	Aldolase
HG535_0C05420	ENOG4105CHR	reductase
HG535_0C05540	ENOG4108PBA	serine threonine protein kinase
HG535_0C05620	ENOG4107SET	aldo keto reductase
HG535_0C05750	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HG535_0C05770	ENOG4105C54	Major Facilitator superfamily
HG535_0C05780	ENOG4105C54	Major Facilitator superfamily
HG535_0C05810	ENOG4105F57	Anthranilate dioxygenase reductase
HG535_0C05830	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
HG535_0C05910	ENOG4105EM7	Selenocysteine-specific translation elongation factor
HG535_0C05930	ENOG4105D9P	serine threonine protein kinase
HG535_0C06000	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HG535_0C06190	ENOG4105CKK	Glycosyl transferase, family 2
HG535_0C06300	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HG535_0C06400	ENOG4105CFM	UPF0317 protein
HG535_0C06410	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HG535_0C06430	ENOG4105E2B	Taurine dioxygenase
HG535_0C06470	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HG535_0C06480	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HG535_0C06490	ENOG4105CQB	FAD linked oxidase domain protein
HG535_0C06510	ENOG4105C5H	ABC transporter
HG535_0C06550	ENOG4105CSP	Major Facilitator Superfamily
HG535_0D00110	ENOG4105EUZ	Beta-lactamase domain protein
HG535_0D00190	ENOG4105DQ4	alcohol dehydrogenase
HG535_0D00200	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HG535_0D00260	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HG535_0D00380	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0D00440	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HG535_0D00480	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HG535_0D00510	ENOG4105D1H	recombination factor protein RarA
HG535_0D00530	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG535_0D00550	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG535_0D00610	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG535_0D00620	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG535_0D00730	ENOG4105CQ7	ATP-dependent helicase
HG535_0D00770	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG535_0D00920	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HG535_0D00930	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG535_0D00960	ENOG4105D9P	serine threonine protein kinase
HG535_0D00980	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG535_0D00990	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HG535_0D01330	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
HG535_0D01380	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0D01390	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HG535_0D01400	ENOG4108MYC	UTP-glucose-1-phosphate uridylyltransferase
HG535_0D01450	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG535_0D01470	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HG535_0D01490	ENOG4105C26	Dehydrogenase
HG535_0D01500	ENOG4105C26	Dehydrogenase
HG535_0D01580	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HG535_0D01640	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
HG535_0D01680	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG535_0D01840	ENOG4105VFU	Rna-binding protein
HG535_0D02020	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG535_0D02030	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG535_0D02040	ENOG4105DGU	Histone deacetylase
HG535_0D02070	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HG535_0D02120	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG535_0D02150	ENOG41077A9	carbonic anhydrase
HG535_0D02380	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HG535_0D02460	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HG535_0D02480	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0D02490	ENOG4105C2C	drug resistance transporter, Bcr CflA
HG535_0D02500	ENOG4105CNH	Multidrug resistance protein MdtL
HG535_0D02550	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG535_0D02560	ENOG4105C0D	helicase
HG535_0D02680	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HG535_0D02690	ENOG4105CRK	lysyL-tRNA synthetase
HG535_0D02740	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0D02770	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HG535_0D02790	ENOG4105CGF	Aromatic amino acid aminotransferase
HG535_0D02960	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HG535_0D03020	ENOG4105C7K	acetolactate synthase
HG535_0D03060	ENOG4105D9P	serine threonine protein kinase
HG535_0D03070	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HG535_0D03130	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HG535_0D03180	ENOG4105D9P	serine threonine protein kinase
HG535_0D03190	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HG535_0D03200	ENOG4105C2M	dna polymerase I
HG535_0D03240	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HG535_0D03260	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
HG535_0D03330	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0D03360	ENOG4105CGF	Aromatic amino acid aminotransferase
HG535_0D03380	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HG535_0D03390	ENOG4105DFM	M18 family aminopeptidase
HG535_0D03400	ENOG4105D9P	serine threonine protein kinase
HG535_0D03490	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HG535_0D03640	ENOG4105CE9	30S ribosomal protein S2
HG535_0D03740	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HG535_0D03840	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
HG535_0D03900	ENOG4105CUZ	uba thif-type nad fad binding protein
HG535_0D03920	ENOG4105C6K	Malic enzyme
HG535_0D04040	ENOG4105TMB	Formate nitrite transporter
HG535_0D04070	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG535_0D04160	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HG535_0D04200	ENOG4107QNK	)-transporter
HG535_0D04230	ENOG4105D06	uba thif-type nad fad binding protein
HG535_0D04240	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HG535_0D04250	ENOG4105DIN	metallophosphoesterase
HG535_0D04330	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HG535_0D04430	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HG535_0D04630	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG535_0D04670	ENOG4105IDI	abc transporter atp-binding protein
HG535_0D04740	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG535_0D04750	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HG535_0D04830	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG535_0D04850	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HG535_0D04870	ENOG4105D6Z	AFG1 family ATPase
HG535_0D05030	ENOG4105W0E	50S ribosomal protein L33
HG535_0D05140	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG535_0D05210	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HG535_0D05230	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HG535_0D05260	ENOG4108V06	Glutathione peroxidase
HG535_0D05390	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HG535_0D05540	ENOG41068W2	Cytochrome p-450
HG535_0D05570	ENOG4105D9P	serine threonine protein kinase
HG535_0D05580	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HG535_0D05630	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HG535_0D05750	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HG535_0D05800	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HG535_0D05820	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HG535_0D05830	ENOG4108QVN	serine threonine protein kinase
HG535_0D05830	ENOG4108QVN	serine threonine protein kinase
HG535_0D05840	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
HG535_0D05960	ENOG4107QNK	)-transporter
HG535_0D06000	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HG535_0D06020	ENOG4105CPQ	Dehydrogenase
HG535_0D06220	ENOG4105CPC	Aldo Keto reductase
HG535_0D06230	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0D06310	ENOG4105C26	Dehydrogenase
HG535_0D06350	ENOG4105CJ3	phosphate transporter
HG535_0E00160	ENOG4105ES4	Nitrilase
HG535_0E00190	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HG535_0E00200	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0E00210	ENOG410904N	short-chain dehydrogenase reductase
HG535_0E00250	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0E00310	ENOG4105BZ1	(ABC) transporter
HG535_0E00420	ENOG4108JJ7	ABC transporter
HG535_0E00430	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HG535_0E00440	ENOG4108X0B	nad(p)h dehydrogenase (quinone)
HG535_0E00530	ENOG4105CB5	ATP-dependent DNA helicase recG
HG535_0E00540	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0E00550	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0E00580	ENOG4105EUJ	GTP cyclohydrolase i
HG535_0E00620	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HG535_0E00750	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HG535_0E00770	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG535_0E00810	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HG535_0E00850	ENOG4105D06	uba thif-type nad fad binding protein
HG535_0E00890	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0E01010	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HG535_0E01040	ENOG4105CTQ	phosphohexokinase
HG535_0E01270	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HG535_0E01280	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HG535_0E01350	ENOG4105C1J	atp-dependent rna helicase
HG535_0E01540	ENOG4105C28	cystathionine
HG535_0E01880	ENOG4107QUV	Domain protein
HG535_0E01930	ENOG4105C8Y	Acetylornithine aminotransferase
HG535_0E02040	ENOG4105CHR	reductase
HG535_0E02090	ENOG4105C54	Major Facilitator superfamily
HG535_0E02100	ENOG4105D82	Glutamate dehydrogenase
HG535_0E02130	ENOG4105C26	Dehydrogenase
HG535_0E02210	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HG535_0E02310	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HG535_0E02390	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HG535_0E02500	ENOG4105CA9	Pyruvate kinase
HG535_0E02510	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HG535_0E02540	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0E02550	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HG535_0E02560	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG535_0E02630	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HG535_0E02760	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HG535_0E03010	ENOG4105C28	cystathionine
HG535_0E03050	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG535_0E03120	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HG535_0E03160	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HG535_0E03230	ENOG4105CYC	Transferase
HG535_0E03260	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HG535_0E03290	ENOG4108JQ1	Dehydrogenase
HG535_0E03330	ENOG4107RAQ	aminopeptidase
HG535_0E03390	ENOG4105C26	Dehydrogenase
HG535_0E03450	ENOG4105CDY	transcriptional regulatory protein
HG535_0E03480	ENOG4108JPW	Aminotransferase
HG535_0E03550	ENOG4105C6T	cysteine synthase
HG535_0E03570	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HG535_0E03780	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
HG535_0E03970	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG535_0E04000	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HG535_0E04010	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HG535_0E04120	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HG535_0E04180	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HG535_0E04210	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HG535_0E04230	ENOG4107QNK	)-transporter
HG535_0E04300	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HG535_0E04500	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HG535_0E04560	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
HG535_0E04570	ENOG4105R2D	cytochrome C
HG535_0E04650	ENOG4107EFR	Flavocytochrome c
HG535_0E04780	ENOG4105C54	Major Facilitator superfamily
HG535_0E04830	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HG535_0E04840	ENOG4105HS1	biotin--protein ligase
HG535_0E04850	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HG535_0E04860	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG535_0E05030	ENOG4105C1J	atp-dependent rna helicase
HG535_0E05090	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
HG535_0E05150	ENOG4107QPD	alcohol dehydrogenase
HG535_0E05270	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG535_0E05430	ENOG4105VFU	Rna-binding protein
HG535_0E05440	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG535_0E05500	ENOG41086MH	50S ribosomal protein L36
HG535_0E05560	ENOG4105C2C	drug resistance transporter, Bcr CflA
HG535_0E05580	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HG535_0E05610	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0E05690	ENOG4108V5V	Serine Threonine protein kinase
HG535_0E05710	ENOG4105C5S	asparaginyl-tRNA synthetase
HG535_0E05780	ENOG4108I0Z	Aconitate hydratase
HG535_0E05800	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0E05840	ENOG4108IQK	o-acetylhomoserine
HG535_0F00250	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG535_0F00260	ENOG4107Q25	Serine Threonine protein kinase
HG535_0F00400	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HG535_0F00670	ENOG4105CVK	Glutamate decarboxylase
HG535_0F00720	ENOG4108IQE	Amp-dependent synthetase and ligase
HG535_0F00770	ENOG4105PGM	cation diffusion facilitator family transporter
HG535_0F00890	ENOG4107RNN	dihydropyrimidinase (EC 3.5.2.2)
HG535_0F00930	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HG535_0F01030	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HG535_0F01160	ENOG4105EMU	Dehydrogenase
HG535_0F01550	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HG535_0F01650	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0F01750	ENOG4105D9P	serine threonine protein kinase
HG535_0F01880	ENOG4105C8Y	Acetylornithine aminotransferase
HG535_0F01920	ENOG4107XM9	(LipO)protein
HG535_0F01940	ENOG4107QNK	)-transporter
HG535_0F02110	ENOG4108PBA	serine threonine protein kinase
HG535_0F02140	ENOG4105HFZ	Membrane
HG535_0F02150	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG535_0F02200	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HG535_0F02360	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HG535_0F02380	ENOG4105D1H	recombination factor protein RarA
HG535_0F02450	ENOG4105IDI	abc transporter atp-binding protein
HG535_0F02540	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0F02720	ENOG4105D1F	ATP-binding protein
HG535_0F02820	ENOG4105CMR	udp-glucose 4-epimerase
HG535_0F02840	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HG535_0F02850	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HG535_0F02860	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HG535_0F02950	ENOG4105CQ7	ATP-dependent helicase
HG535_0F02980	ENOG4105CEY	Amp-dependent synthetase and ligase
HG535_0F03000	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0F03020	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HG535_0F03030	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HG535_0F03110	ENOG4108R6K	riboflavin synthase, subunit alpha
HG535_0F03150	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HG535_0F03370	ENOG410870F	Cyclic nucleotide-binding protein
HG535_0F03400	ENOG4105D9P	serine threonine protein kinase
HG535_0F03490	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0F03560	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HG535_0F03590	ENOG4105CFH	Aspartokinase
HG535_0F03660	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HG535_0F03680	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HG535_0F03720	ENOG4105KME	endoribonuclease L-psp
HG535_0F03750	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HG535_0F03760	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HG535_0F03800	ENOG4108I9X	Isocitrate lyase
HG535_0F03840	ENOG4105CAS	nag kinase
HG535_0F03890	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HG535_0F03900	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HG535_0F03930	ENOG4105KME	endoribonuclease L-psp
HG535_0F03980	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HG535_0F04100	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HG535_0F04140	ENOG4105MYT	Heat shock protein
HG535_0F04250	ENOG4105D3G	Pseudouridine synthase
HG535_0F04500	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HG535_0F04530	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HG535_0F04590	ENOG4105PGM	cation diffusion facilitator family transporter
HG535_0F04600	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HG535_0F04630	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HG535_0F04650	ENOG4107Z36	nucleotidyl transferase
HG535_0F04670	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG535_0F04920	ENOG4107QNK	)-transporter
HG535_0F04930	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HG535_0F04940	ENOG4107YD0	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HG535_0F05000	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HG535_0F05020	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HG535_0F05030	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HG535_0F05080	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG535_0F05150	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HG535_0F05270	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HG535_0F05280	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HG535_0F05370	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HG535_0F05500	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HG535_0F05540	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HG535_0F05610	ENOG4105D9P	serine threonine protein kinase
HG535_0F05630	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HG535_0F05650	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HG535_0F05660	ENOG4105CHF	Glutathione S-transferase
HG535_0F05700	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HG535_0F05770	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HG535_0F05790	ENOG4107QK2	May be the GTPase, regulating ATP sulfurylase activity (By similarity)
HG535_0F05820	ENOG4105CQ7	ATP-dependent helicase
HG535_0F05860	ENOG4105CHR	reductase
HG535_0F05970	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HG535_0F06000	ENOG4105BZU	Histidine kinase
HG535_0F06080	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HG535_0F06120	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HG535_0F06190	ENOG4105CHU	acetyl-coa acetyltransferase
HG535_0F06260	ENOG4107QNK	)-transporter
HG535_0F06290	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HG535_0F06340	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0G00130	ENOG4107SET	aldo keto reductase
HG535_0G00140	ENOG4105CPC	Aldo Keto reductase
HG535_0G00150	ENOG4105C54	Major Facilitator superfamily
HG535_0G00160	ENOG4105DEI	Mannitol dehydrogenase
HG535_0G00300	ENOG4105VFU	Rna-binding protein
HG535_0G00330	ENOG4105DJ4	phosphatidylserine decarboxylase
HG535_0G00340	ENOG4108UK2	deaminase
HG535_0G00350	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HG535_0G00420	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG535_0G00460	ENOG4108QVN	serine threonine protein kinase
HG535_0G00490	ENOG4105BZU	Histidine kinase
HG535_0G00530	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HG535_0G00540	ENOG4107WDG	serine threonine protein kinase
HG535_0G00660	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HG535_0G00770	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HG535_0G00830	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HG535_0G00970	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HG535_0G01130	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0G01180	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HG535_0G01200	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HG535_0G01390	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HG535_0G01450	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HG535_0G01500	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
HG535_0G01610	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HG535_0G01630	ENOG4105CQB	FAD linked oxidase domain protein
HG535_0G01640	ENOG4105CV8	reductase
HG535_0G01690	ENOG4105C22	threonyL-tRNA synthetase
HG535_0G01730	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HG535_0G01780	ENOG4105DGU	Histone deacetylase
HG535_0G01860	ENOG4105C5I	Dehydrogenase
HG535_0G01870	ENOG4105C28	cystathionine
HG535_0G01920	ENOG4108PBA	serine threonine protein kinase
HG535_0G01930	ENOG4105D9P	serine threonine protein kinase
HG535_0G02020	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HG535_0G02130	ENOG4105VFU	Rna-binding protein
HG535_0G02180	ENOG4105CTM	Glycoside hydrolase family 5
HG535_0G02210	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HG535_0G02220	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HG535_0G02300	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HG535_0G02320	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HG535_0G02400	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HG535_0G02430	ENOG4105CY0	Metallo-Beta-Lactamase
HG535_0G02500	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HG535_0G02640	ENOG4105CX6	glutaminyL-tRNA synthetase
HG535_0G02680	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG535_0G02830	ENOG4108PBA	serine threonine protein kinase
HG535_0G02920	ENOG4105EUB	pirin domain protein
HG535_0G03020	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HG535_0G03030	ENOG4105C9Q	fumarate hydratase class II
HG535_0G03050	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HG535_0G03110	ENOG4105BZ1	(ABC) transporter
HG535_0G03160	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HG535_0G03170	ENOG4108IQI	permease
HG535_0G03210	ENOG4108HKT	sucrose-6-phosphate hydrolase
HG535_0G03230	ENOG4105CKI	cobalamin synthesis protein
HG535_0G03250	ENOG4105C0A	alcohol dehydrogenase
HG535_0G03300	ENOG4108V5V	Serine Threonine protein kinase
HG535_0G03390	ENOG4105C34	Pseudouridine synthase
HG535_0G03450	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HG535_0G03560	ENOG4106A3M	Cytochrome p-450
HG535_0G03640	ENOG4105KZX	Pterin carbinolamine dehydratase
HG535_0G03700	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
HG535_0G03790	ENOG4105C7S	Dehydrogenase
HG535_0G03870	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HG535_0G04030	ENOG4105BZ1	(ABC) transporter
HG535_0G04040	ENOG4108DT4	serine threonine protein kinase
HG535_0G04190	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HG535_0G04270	ENOG4105D9P	serine threonine protein kinase
HG535_0G04320	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HG535_0G04380	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HG535_0G04390	ENOG4105VG0	50S ribosomal protein l34
HG535_0G04420	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0G04470	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG535_0G04490	ENOG4105EF1	ribulokinase
HG535_0G04590	ENOG4108JYK	Dehydrogenase
HG535_0G04640	ENOG4105M2J	Glutaredoxin
HG535_0G04680	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG535_0G04690	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG535_0G04710	ENOG4105DJ0	Poly(A) Polymerase
HG535_0G04780	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HG535_0G04880	ENOG4107QSE	Dipeptidase
HG535_0G04900	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HG535_0G04910	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HG535_0G05020	ENOG4105CX6	glutaminyL-tRNA synthetase
HG535_0G05040	ENOG4105CV8	reductase
HG535_0G05070	ENOG4107RF4	Phosphodiesterase
HG535_0G05080	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
HG535_0G05120	ENOG4105C9X	ppx gppa phosphatase
HG535_0G05150	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HG535_0G05160	ENOG4107QNK	)-transporter
HG535_0G05180	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0G05220	ENOG4105CHR	reductase
HG535_0G05260	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HG535_0G05350	ENOG4108PPE	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG535_0G05390	ENOG4105D1H	recombination factor protein RarA
HG535_0G05420	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HG535_0G05480	ENOG4107SET	aldo keto reductase
HG535_0G05500	ENOG4105BZ1	(ABC) transporter
HG535_0G05550	ENOG4105DDQ	anthranilate synthase
HG535_0G05630	ENOG4107QNK	)-transporter
HG535_0G05640	ENOG4108IQI	permease
HG535_0G05660	ENOG4108IQI	permease
HG535_0H00120	ENOG4105C26	Dehydrogenase
HG535_0H00130	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HG535_0H00140	ENOG4105CPC	Aldo Keto reductase
HG535_0H00160	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HG535_0H00170	ENOG4105CV8	reductase
HG535_0H00190	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HG535_0H00410	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HG535_0H00450	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HG535_0H00660	ENOG4105DJV	ribulose-phosphate 3-epimerase
HG535_0H00730	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HG535_0H00790	ENOG4108IQI	permease
HG535_0H00800	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HG535_0H00830	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HG535_0H00860	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HG535_0H00910	ENOG4105D9P	serine threonine protein kinase
HG535_0H00980	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
HG535_0H00990	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HG535_0H01050	ENOG4105D9P	serine threonine protein kinase
HG535_0H01080	ENOG4105C4R	Atp-dependent dna helicase
HG535_0H01130	ENOG4105DBV	ornithine carbamoyltransferase
HG535_0H01280	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG535_0H01300	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0H01450	ENOG4105D3R	alkyl hydroperoxide reductase
HG535_0H01490	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HG535_0H01560	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0H01570	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HG535_0H01620	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HG535_0H01640	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0H01660	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
HG535_0H01700	ENOG4105C0D	helicase
HG535_0H01770	ENOG4105C10	Electron transfer flavoprotein
HG535_0H01780	ENOG4105CHH	sulfate transporter
HG535_0H01790	ENOG4107RAQ	aminopeptidase
HG535_0H01870	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HG535_0H01880	ENOG4105C1J	atp-dependent rna helicase
HG535_0H01960	ENOG4105K5M	30s ribosomal protein S16
HG535_0H02010	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG535_0H02060	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HG535_0H02140	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HG535_0H02190	ENOG4107QN2	dihydrolipoyl dehydrogenase
HG535_0H02300	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HG535_0H02360	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HG535_0H02420	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HG535_0H02560	ENOG4105C31	Tryptophanyl-tRNA synthetase
HG535_0H02590	ENOG4105C59	p-type ATPase
HG535_0H02680	ENOG4105DC8	reductase
HG535_0H02710	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0H02810	ENOG4107T8T	UPF0173 metal-dependent hydrolase
HG535_0H02830	ENOG4105C9M	aspartyl-trna synthetase
HG535_0H02890	ENOG4105CFG	Acts as a chaperone (By similarity)
HG535_0H03030	ENOG4105C1J	atp-dependent rna helicase
HG535_0H03070	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HG535_0H03090	ENOG4108UJD	30S ribosomal protein S9
HG535_0H03200	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HG535_0H03240	ENOG4105D1H	recombination factor protein RarA
HG535_0H03260	ENOG4105C4R	Atp-dependent dna helicase
HG535_0H03280	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HG535_0H03310	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HG535_0H03340	ENOG4105D9P	serine threonine protein kinase
HG535_0H03420	ENOG4107QNK	)-transporter
HG535_0H03490	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
HG535_0H03750	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HG535_0H03770	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HG535_0H03800	ENOG4105E33	succinate dehydrogenase
HG535_0H03940	ENOG4105D1F	ATP-binding protein
HG535_0H03990	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HG535_0H04120	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HG535_0H04150	ENOG4105CFH	Aspartokinase
HG535_0H04250	ENOG4105D9P	serine threonine protein kinase
HG535_0H04300	ENOG4105CM2	brancheD-chain amino acid aminotransferase