locus-tag	class	description
HG535_0A00160	COG0833	amino acid
HG535_0A00170	COG2040	homocysteine
HG535_0A00310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG535_0A00640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG535_0A00680	COG0833	amino acid
HG535_0A00700	COG0515	serine threonine protein kinase
HG535_0A00700	COG2815	serine threonine protein kinase
HG535_0A00840	COG1132	(ABC) transporter
HG535_0A00850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG535_0A00860	COG1819	glycosyl
HG535_0A00920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG535_0A01010	COG0833	amino acid
HG535_0A01020	COG0833	amino acid
HG535_0A01100	COG0484	heat shock protein binding
HG535_0A01210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG535_0A01220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG535_0A01280	COG1196	nuclear chromosome segregation
HG535_0A01300	COG0484	heat shock protein binding
HG535_0A01320	COG0215	cysteine-tRNA ligase activity
HG535_0A01520	COG0753	catalase activity
HG535_0A01550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG535_0A01570	COG0471	metal ion transport
HG535_0A01580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG535_0A01650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG535_0A01840	COG1113	amino acid transport
HG535_0A01870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG535_0A01930	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HG535_0A02000	COG0423	glycine-tRNA ligase activity
HG535_0A02050	COG2895	sulfate adenylyltransferase (ATP) activity
HG535_0A02120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG535_0A02160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0A02270	COG0316	Belongs to the HesB IscA family
HG535_0A02600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG535_0A02640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG535_0A02710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HG535_0A02920	COG0417	DNA replication proofreading
HG535_0A03050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HG535_0A03090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG535_0A03120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG535_0A03170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG535_0A03170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG535_0A03250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HG535_0A03320	COG1222	aaa ATPase
HG535_0A03350	COG0154	amidase activity
HG535_0A03430	COG2234	aminopeptidase activity
HG535_0A03440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG535_0A03460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0A03500	COG0149	triose-phosphate isomerase activity
HG535_0A03540	COG0408	coproporphyrinogen oxidase activity
HG535_0A03600	COG0051	transcription antitermination factor activity, RNA binding
HG535_0A03610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG535_0A03630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG535_0A03650	COG2815	serine threonine protein kinase
HG535_0A03650	COG0515	serine threonine protein kinase
HG535_0A03670	COG1024	Enoyl-CoA hydratase
HG535_0A03700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG535_0A03810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG535_0A03810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG535_0A03820	COG0513	Belongs to the DEAD box helicase family
HG535_0A03850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG535_0A03860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HG535_0A03890	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG535_0A03900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG535_0A03940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG535_0A03960	COG0010	Belongs to the arginase family
HG535_0A03990	COG0513	Belongs to the DEAD box helicase family
HG535_0A04010	COG0443	Heat shock 70 kDa protein
HG535_0A04020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG535_0A04100	COG1953	Uracil, thiamine, allantoin
HG535_0A04210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG535_0A04300	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0A04310	COG0557	exoribonuclease II activity
HG535_0A04320	COG0233	cytoplasmic translational termination
HG535_0A04380	COG1111	helicase
HG535_0A04380	COG1205	dead DEAH box helicase
HG535_0A04470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG535_0A04540	COG0483	inositol monophosphate 1-phosphatase activity
HG535_0A04580	COG1914	H( )-stimulated, divalent metal cation uptake system
HG535_0A04640	COG0534	Mate efflux family protein
HG535_0A04650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG535_0A04710	COG0083	homoserine kinase activity
HG535_0A04720	COG0612	Peptidase, M16
HG535_0A04840	COG0588	phosphoglycerate mutase activity
HG535_0A04850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG535_0A04880	COG1053	succinate dehydrogenase
HG535_0A04900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0A05000	COG0513	Belongs to the DEAD box helicase family
HG535_0A05020	COG0443	Heat shock 70 kDa protein
HG535_0A05070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG535_0A05270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG535_0A05350	COG0513	Belongs to the DEAD box helicase family
HG535_0A05520	COG0180	Tryptophanyl-tRNA synthetase
HG535_0A05620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0A05670	COG0166	Belongs to the GPI family
HG535_0A05750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG535_0A05760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0A05780	COG2119	membrane
HG535_0A05860	COG0513	Belongs to the DEAD box helicase family
HG535_0A05870	COG2815	serine threonine protein kinase
HG535_0A05870	COG0515	serine threonine protein kinase
HG535_0A05880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG535_0A05890	COG0515	serine threonine protein kinase
HG535_0A05930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HG535_0A05970	COG3842	ATPase activity
HG535_0A06000	COG0736	holo-[acyl-carrier-protein] synthase activity
HG535_0A06060	COG0285	dihydrofolate synthase activity
HG535_0A06080	COG0585	pseudouridine synthase activity
HG535_0A06180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG535_0A06190	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0A06230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG535_0A06280	COG0417	DNA replication proofreading
HG535_0A06320	COG0484	heat shock protein binding
HG535_0A06370	COG0297	glycogen (starch) synthase activity
HG535_0A06410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0A06430	COG0109	protoheme IX farnesyltransferase activity
HG535_0A06490	COG4991	sh3 domain protein
HG535_0A06490	COG3064	Membrane
HG535_0A06490	COG0515	serine threonine protein kinase
HG535_0A06550	COG2814	Major facilitator Superfamily
HG535_0A06580	COG0736	holo-[acyl-carrier-protein] synthase activity
HG535_0A06630	COG0515	serine threonine protein kinase
HG535_0A06680	COG0326	Molecular chaperone. Has ATPase activity
HG535_0A06750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG535_0A06770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG535_0A06770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG535_0A06780	COG0514	ATP-dependent DNA helicase (RecQ)
HG535_0A06810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG535_0A07050	COG1643	Atp-dependent helicase
HG535_0A07110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG535_0A07120	COG4770	biotin carboxylase activity
HG535_0A07170	COG2226	methyltransferase
HG535_0A07370	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG535_0A07400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG535_0A07410	COG0523	cobalamin synthesis protein
HG535_0A07480	COG0512	Glutamine amidotransferase of anthranilate synthase
HG535_0A07480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG535_0A07570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG535_0A07590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG535_0A07600	COG0513	Belongs to the DEAD box helicase family
HG535_0A07670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG535_0A07760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG535_0A07850	COG1716	ATPase activity
HG535_0A07850	COG1131	(ABC) transporter
HG535_0A07850	COG0842	Transport permease protein
HG535_0A07870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG535_0A07930	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0A07940	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0A07980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG535_0A08050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG535_0A08150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG535_0A08250	COG0515	serine threonine protein kinase
HG535_0A08310	COG0012	GTP binding
HG535_0A08340	COG0833	amino acid
HG535_0A08470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0A08660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG535_0A08710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG535_0A08730	COG0450	alkyl hydroperoxide reductase
HG535_0A08740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG535_0A08790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG535_0A08810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0A08820	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG535_0A08900	COG0673	inositol 2-dehydrogenase activity
HG535_0A08910	COG0415	Belongs to the DNA photolyase family
HG535_0A08930	COG2814	Major facilitator Superfamily
HG535_0A08970	COG3345	alpha-galactosidase
HG535_0A08980	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0A09000	COG0306	phosphate transporter
HG535_0A09020	COG0163	prenyltransferase activity
HG535_0A09040	COG0246	Mannitol dehydrogenase
HG535_0A09070	COG0667	Aldo Keto reductase
HG535_0A09080	COG0667	Aldo Keto reductase
HG535_0A09120	COG2814	Major facilitator Superfamily
HG535_0A09160	COG0252	asparaginase activity
HG535_0B00110	COG1953	Uracil, thiamine, allantoin
HG535_0B00170	COG0842	Transport permease protein
HG535_0B00170	COG1131	(ABC) transporter
HG535_0B00170	COG1716	ATPase activity
HG535_0B00180	COG0656	L-ascorbic acid biosynthetic process
HG535_0B00240	COG2814	Major facilitator Superfamily
HG535_0B00270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG535_0B00280	COG0477	Major facilitator Superfamily
HG535_0B00330	COG1185	polyribonucleotide nucleotidyltransferase activity
HG535_0B00370	COG0529	Catalyzes the synthesis of activated sulfate
HG535_0B00370	COG2046	Belongs to the sulfate adenylyltransferase family
HG535_0B00380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG535_0B00510	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HG535_0B00570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG535_0B00580	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HG535_0B00590	COG1946	Acyl-CoA thioesterase
HG535_0B00630	COG0235	Class ii aldolase
HG535_0B00640	COG0662	Cupin 2, conserved barrel domain protein
HG535_0B00670	COG0560	Phosphoserine phosphatase
HG535_0B00670	COG3830	Belongs to the UPF0237 family
HG535_0B00700	COG3961	Belongs to the TPP enzyme family
HG535_0B00710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0B00810	COG0222	ribosome binding
HG535_0B00820	COG0515	serine threonine protein kinase
HG535_0B00820	COG2815	serine threonine protein kinase
HG535_0B00840	COG2816	NAD+ diphosphatase activity
HG535_0B00850	COG0584	glycerophosphoryl diester phosphodiesterase
HG535_0B00910	COG0515	serine threonine protein kinase
HG535_0B00910	COG2815	serine threonine protein kinase
HG535_0B00920	COG0513	Belongs to the DEAD box helicase family
HG535_0B01000	COG0352	thiamine-phosphate diphosphorylase activity
HG535_0B01110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG535_0B01120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HG535_0B01170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HG535_0B01190	COG1546	Belongs to the CinA family
HG535_0B01190	COG1058	Belongs to the CinA family
HG535_0B01200	COG0488	(ABC) transporter
HG535_0B01220	COG0463	Glycosyl transferase, family 2
HG535_0B01270	COG1119	ATPase activity
HG535_0B01280	COG0156	8-amino-7-oxononanoate synthase activity
HG535_0B01340	COG1612	heme a metabolic process
HG535_0B01420	COG0672	)-iron permease
HG535_0B01450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HG535_0B01540	COG0513	Belongs to the DEAD box helicase family
HG535_0B01590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG535_0B01590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG535_0B01610	COG2814	Major facilitator Superfamily
HG535_0B01640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG535_0B01660	COG0386	Belongs to the glutathione peroxidase family
HG535_0B01670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0B01690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG535_0B01710	COG2814	Major facilitator Superfamily
HG535_0B01750	COG0107	imidazoleglycerol-phosphate synthase activity
HG535_0B01760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG535_0B01770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG535_0B01820	COG0484	heat shock protein binding
HG535_0B01840	COG0519	Catalyzes the synthesis of GMP from XMP
HG535_0B01840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG535_0B02020	COG0004	ammonium transporteR
HG535_0B02100	COG0367	asparagine synthase
HG535_0B02110	COG0659	secondary active sulfate transmembrane transporter activity
HG535_0B02260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG535_0B02290	COG2814	Major facilitator Superfamily
HG535_0B02350	COG0517	IMP dehydrogenase activity
HG535_0B02350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG535_0B02390	COG0058	SHG alpha-glucan phosphorylase activity
HG535_0B02410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG535_0B02430	COG1183	phosphatidylcholine synthase activity
HG535_0B02610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG535_0B02640	COG0488	(ABC) transporter
HG535_0B02720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0B02730	COG1121	(ABC) transporter
HG535_0B02880	COG2351	hydroxyisourate hydrolase activity
HG535_0B02980	COG0436	Aminotransferase
HG535_0B03130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG535_0B03150	COG1643	Atp-dependent helicase
HG535_0B03170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG535_0B03240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG535_0B03260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG535_0B03290	COG0022	dehydrogenase e1 component
HG535_0B03290	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG535_0B03330	COG0515	serine threonine protein kinase
HG535_0B03410	COG0513	Belongs to the DEAD box helicase family
HG535_0B03520	COG2233	PERMEase
HG535_0B03530	COG0085	RNA polymerase activity
HG535_0B03550	COG0009	L-threonylcarbamoyladenylate synthase
HG535_0B03680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0B03790	COG0028	Belongs to the TPP enzyme family
HG535_0B03800	COG0017	Asparaginyl-tRNA synthetase
HG535_0B03870	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0B03970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG535_0B04030	COG0126	phosphoglycerate kinase activity
HG535_0B04040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HG535_0B04120	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG535_0B04150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG535_0B04230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG535_0B04240	COG0484	heat shock protein binding
HG535_0B04280	COG0473	3-isopropylmalate dehydrogenase activity
HG535_0B04290	COG1104	cysteine desulfurase activity
HG535_0B04360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG535_0B04370	COG0440	acetolactate synthase activity
HG535_0B04380	COG0538	isocitrate dehydrogenase activity
HG535_0B04400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HG535_0B04430	COG0488	(ABC) transporter
HG535_0B04450	COG4991	sh3 domain protein
HG535_0B04450	COG3064	Membrane
HG535_0B04450	COG0515	serine threonine protein kinase
HG535_0B04530	COG0442	prolyl-tRNA aminoacylation
HG535_0B04580	COG0277	FAD linked oxidase domain protein
HG535_0B04610	COG0070	glutamate synthase
HG535_0B04610	COG0067	glutamate synthase
HG535_0B04610	COG0069	glutamate synthase activity
HG535_0B04640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG535_0B04680	COG0515	serine threonine protein kinase
HG535_0B04680	COG2815	serine threonine protein kinase
HG535_0B04780	COG0406	alpha-ribazole phosphatase activity
HG535_0B04800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG535_0B04900	COG0049	tRNA binding
HG535_0B04950	COG1953	Uracil, thiamine, allantoin
HG535_0B05080	COG0656	L-ascorbic acid biosynthetic process
HG535_0B05290	COG0366	Alpha amylase catalytic
HG535_0B05370	COG0515	serine threonine protein kinase
HG535_0B05370	COG2815	serine threonine protein kinase
HG535_0B05660	COG0113	porphobilinogen synthase activity
HG535_0B05700	COG0724	RNA recognition motif
HG535_0B05750	COG0724	RNA recognition motif
HG535_0B05840	COG0515	serine threonine protein kinase
HG535_0B05840	COG2815	serine threonine protein kinase
HG535_0B05970	COG0515	serine threonine protein kinase
HG535_0B06000	COG0525	valine-tRNA ligase activity
HG535_0B06030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG535_0B06200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG535_0B06230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG535_0B06250	COG2365	Tyrosine phosphatase family
HG535_0B06280	COG0495	leucyl-tRNA aminoacylation
HG535_0B06470	COG0538	isocitrate dehydrogenase activity
HG535_0B06510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0B06580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG535_0B06640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG535_0B06740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG535_0B06760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG535_0B06830	COG4178	(ABC) transporter
HG535_0B06870	COG1643	Atp-dependent helicase
HG535_0B06910	COG0418	dihydroorotase activity
HG535_0B06930	COG1546	Belongs to the CinA family
HG535_0B06930	COG1058	Belongs to the CinA family
HG535_0B06970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG535_0B07030	COG0833	amino acid
HG535_0C00180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG535_0C00180	COG1017	nitric oxide dioxygenase activity
HG535_0C00200	COG1132	(ABC) transporter
HG535_0C00210	COG2814	Major facilitator Superfamily
HG535_0C00220	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HG535_0C00320	COG0405	Gamma-glutamyltransferase
HG535_0C00430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG535_0C00480	COG0049	tRNA binding
HG535_0C00510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG535_0C00590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG535_0C00740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG535_0C00770	COG2815	serine threonine protein kinase
HG535_0C00770	COG0515	serine threonine protein kinase
HG535_0C00840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG535_0C00900	COG0667	Aldo Keto reductase
HG535_0C00940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG535_0C00960	COG1643	Atp-dependent helicase
HG535_0C00970	COG2814	Major facilitator Superfamily
HG535_0C00980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG535_0C01070	COG0443	Heat shock 70 kDa protein
HG535_0C01110	COG1956	GAF domain-containing protein
HG535_0C01190	COG0105	UTP biosynthetic process
HG535_0C01210	COG2815	serine threonine protein kinase
HG535_0C01210	COG0515	serine threonine protein kinase
HG535_0C01270	COG0833	amino acid
HG535_0C01340	COG1785	Belongs to the alkaline phosphatase family
HG535_0C01380	COG0753	catalase activity
HG535_0C01450	COG0515	serine threonine protein kinase
HG535_0C01470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG535_0C01560	COG0183	Belongs to the thiolase family
HG535_0C01570	COG3265	gluconokinase activity
HG535_0C01580	COG0515	serine threonine protein kinase
HG535_0C01620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG535_0C01670	COG0513	Belongs to the DEAD box helicase family
HG535_0C01680	COG0154	amidase activity
HG535_0C01770	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG535_0C01870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG535_0C01900	COG0572	uridine kinase
HG535_0C01920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG535_0C01950	COG0318	PFAM AMP-dependent synthetase and ligase
HG535_0C01970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG535_0C02020	COG0259	pyridoxamine-phosphate oxidase activity
HG535_0C02050	COG2264	protein methyltransferase activity
HG535_0C02060	COG0088	Forms part of the polypeptide exit tunnel
HG535_0C02080	COG0575	Belongs to the CDS family
HG535_0C02130	COG1999	signal sequence binding
HG535_0C02180	COG1953	Uracil, thiamine, allantoin
HG535_0C02190	COG0842	Transport permease protein
HG535_0C02190	COG1131	(ABC) transporter
HG535_0C02190	COG1716	ATPase activity
HG535_0C02230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG535_0C02330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG535_0C02340	COG0142	geranyltranstransferase activity
HG535_0C02440	COG0135	phosphoribosylanthranilate isomerase activity
HG535_0C02490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG535_0C02540	COG0515	serine threonine protein kinase
HG535_0C02560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG535_0C02590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG535_0C02610	COG0515	serine threonine protein kinase
HG535_0C02610	COG2815	serine threonine protein kinase
HG535_0C02640	COG0351	phosphomethylpyrimidine kinase
HG535_0C02640	COG0352	thiamine-phosphate diphosphorylase activity
HG535_0C02670	COG0137	argininosuccinate synthase activity
HG535_0C02680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG535_0C02700	COG1253	flavin adenine dinucleotide binding
HG535_0C02720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG535_0C02750	COG0515	serine threonine protein kinase
HG535_0C02830	COG0564	pseudouridine synthase activity
HG535_0C02860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG535_0C02940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HG535_0C03060	COG1131	(ABC) transporter
HG535_0C03060	COG1716	ATPase activity
HG535_0C03060	COG0842	Transport permease protein
HG535_0C03070	COG4702	Belongs to the UPF0303 family
HG535_0C03190	COG2226	methyltransferase
HG535_0C03560	COG0515	serine threonine protein kinase
HG535_0C03560	COG2815	serine threonine protein kinase
HG535_0C03630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0C03670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG535_0C03690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG535_0C03700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG535_0C03750	COG0018	arginyl-trna synthetase
HG535_0C03760	COG2814	Major facilitator Superfamily
HG535_0C03780	COG2814	Major facilitator Superfamily
HG535_0C03920	COG0656	L-ascorbic acid biosynthetic process
HG535_0C03940	COG0492	ferredoxin-NADP+ reductase activity
HG535_0C03960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG535_0C04040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG535_0C04060	COG0626	cystathionine gamma-synthase activity
HG535_0C04070	COG1362	aminopeptidase activity
HG535_0C04090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG535_0C04310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0C04330	COG0493	'glutamate synthase
HG535_0C04380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG535_0C04390	COG3961	Belongs to the TPP enzyme family
HG535_0C04450	COG0557	exoribonuclease II activity
HG535_0C04460	COG0488	(ABC) transporter
HG535_0C04480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG535_0C04570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG535_0C04580	COG0017	Asparaginyl-tRNA synthetase
HG535_0C04590	COG0165	Argininosuccinate lyase
HG535_0C04630	COG1252	NADH dehydrogenase
HG535_0C04760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG535_0C04770	COG0481	GTPase activity
HG535_0C04790	COG0515	serine threonine protein kinase
HG535_0C04840	COG4581	dead DEAH box helicase
HG535_0C04930	COG0436	Aminotransferase
HG535_0C05010	COG0203	ribosomal protein L17
HG535_0C05020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG535_0C05240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG535_0C05340	COG0191	fructose-bisphosphate aldolase activity
HG535_0C05620	COG0667	Aldo Keto reductase
HG535_0C05730	COG1252	NADH dehydrogenase
HG535_0C05750	COG0193	aminoacyl-tRNA hydrolase activity
HG535_0C05770	COG0477	Major facilitator Superfamily
HG535_0C05780	COG0477	Major facilitator Superfamily
HG535_0C05810	COG0543	2 iron, 2 sulfur cluster binding
HG535_0C05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG535_0C05830	COG3425	synthase
HG535_0C06000	COG0175	sulfate reduction
HG535_0C06190	COG0463	Glycosyl transferase, family 2
HG535_0C06300	COG4106	trans-aconitate 2-methyltransferase activity
HG535_0C06300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG535_0C06400	COG4336	lyase activity
HG535_0C06410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG535_0C06410	COG1017	nitric oxide dioxygenase activity
HG535_0C06430	COG2175	clavaminate synthase activity
HG535_0C06470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG535_0C06480	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG535_0C06490	COG0277	FAD linked oxidase domain protein
HG535_0C06510	COG0488	(ABC) transporter
HG535_0C06550	COG2271	Major facilitator Superfamily
HG535_0D00110	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HG535_0D00190	COG1064	alcohol dehydrogenase
HG535_0D00200	COG0167	dihydroorotate dehydrogenase activity
HG535_0D00260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG535_0D00380	COG0484	heat shock protein binding
HG535_0D00440	COG0402	S-adenosylhomocysteine deaminase activity
HG535_0D00480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG535_0D00510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG535_0D00530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG535_0D00550	COG0459	protein refolding
HG535_0D00610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG535_0D00620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG535_0D00710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0D00730	COG1643	Atp-dependent helicase
HG535_0D00770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG535_0D00920	COG1160	GTP binding
HG535_0D00930	COG0039	L-malate dehydrogenase activity
HG535_0D00970	COG3961	Belongs to the TPP enzyme family
HG535_0D00990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG535_0D01100	COG0412	Dienelactone hydrolase
HG535_0D01150	COG0681	Belongs to the peptidase S26 family
HG535_0D01330	COG0003	Pfam Anion-transporting ATPase
HG535_0D01380	COG0484	heat shock protein binding
HG535_0D01390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG535_0D01400	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HG535_0D01450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG535_0D01490	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0D01500	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0D01580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG535_0D01640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG535_0D01680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG535_0D01710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG535_0D01720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0D01720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0D01840	COG0724	RNA recognition motif
HG535_0D02020	COG0473	3-isopropylmalate dehydrogenase activity
HG535_0D02030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG535_0D02070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG535_0D02120	COG0473	3-isopropylmalate dehydrogenase activity
HG535_0D02150	COG0288	reversible hydration of carbon dioxide
HG535_0D02380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG535_0D02460	COG2890	protein-(glutamine-N5) methyltransferase activity
HG535_0D02480	COG0484	heat shock protein binding
HG535_0D02490	COG2814	Major facilitator Superfamily
HG535_0D02500	COG2814	Major facilitator Superfamily
HG535_0D02530	COG4221	oxidoreductase activity
HG535_0D02550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG535_0D02560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0D02670	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG535_0D02680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG535_0D02690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG535_0D02770	COG0138	bifunctional purine biosynthesis protein purh
HG535_0D02960	COG0285	dihydrofolate synthase activity
HG535_0D03020	COG0028	Belongs to the TPP enzyme family
HG535_0D03060	COG0515	serine threonine protein kinase
HG535_0D03060	COG2815	serine threonine protein kinase
HG535_0D03070	COG0033	Phosphoglucomutase
HG535_0D03130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG535_0D03180	COG2815	serine threonine protein kinase
HG535_0D03180	COG0515	serine threonine protein kinase
HG535_0D03190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HG535_0D03200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG535_0D03200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG535_0D03240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG535_0D03260	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HG535_0D03330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0D03340	COG2814	Major facilitator Superfamily
HG535_0D03360	COG1448	Aminotransferase
HG535_0D03380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG535_0D03390	COG1362	aminopeptidase activity
HG535_0D03400	COG2815	serine threonine protein kinase
HG535_0D03400	COG0515	serine threonine protein kinase
HG535_0D03490	COG2255	four-way junction helicase activity
HG535_0D03640	COG0052	Belongs to the universal ribosomal protein uS2 family
HG535_0D03740	COG0529	Catalyzes the synthesis of activated sulfate
HG535_0D03840	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0D03900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG535_0D03920	COG0281	malic enzyme
HG535_0D04040	COG2116	formate transmembrane transporter activity
HG535_0D04070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG535_0D04160	COG0546	phosphoglycolate phosphatase activity
HG535_0D04180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG535_0D04200	COG2814	Major facilitator Superfamily
HG535_0D04230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG535_0D04240	COG0473	3-isopropylmalate dehydrogenase activity
HG535_0D04250	COG1408	metallophosphoesterase
HG535_0D04330	COG0200	Binds to the 23S rRNA
HG535_0D04430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG535_0D04510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0D04560	COG0656	L-ascorbic acid biosynthetic process
HG535_0D04630	COG0085	RNA polymerase activity
HG535_0D04670	COG0842	Transport permease protein
HG535_0D04670	COG1131	(ABC) transporter
HG535_0D04670	COG1716	ATPase activity
HG535_0D04740	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG535_0D04750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG535_0D04830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG535_0D04850	COG1394	ATPase activity, coupled to movement of substances
HG535_0D04870	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG535_0D05030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG535_0D05140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG535_0D05210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG535_0D05230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG535_0D05260	COG0386	Belongs to the glutathione peroxidase family
HG535_0D05360	COG0450	alkyl hydroperoxide reductase
HG535_0D05390	COG0194	GDP metabolic process
HG535_0D05540	COG2124	cytochrome p450
HG535_0D05570	COG0515	serine threonine protein kinase
HG535_0D05580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG535_0D05630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG535_0D05750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG535_0D05800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG535_0D05820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HG535_0D05830	COG0515	serine threonine protein kinase
HG535_0D05830	COG0515	serine threonine protein kinase
HG535_0D05840	COG0072	phenylalanine-tRNA ligase activity
HG535_0D05960	COG2814	Major facilitator Superfamily
HG535_0D06000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG535_0D06020	COG1063	alcohol dehydrogenase
HG535_0D06220	COG0667	Aldo Keto reductase
HG535_0D06230	COG0154	amidase activity
HG535_0D06240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG535_0D06310	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0D06350	COG0306	phosphate transporter
HG535_0E00150	COG0475	glutathione-regulated potassium exporter activity
HG535_0E00160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG535_0E00190	COG2017	converts alpha-aldose to the beta-anomer
HG535_0E00200	COG0154	amidase activity
HG535_0E00210	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0E00250	COG0484	heat shock protein binding
HG535_0E00310	COG1132	(ABC) transporter
HG535_0E00420	COG5265	(ABC) transporter
HG535_0E00440	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG535_0E00530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG535_0E00540	COG0154	amidase activity
HG535_0E00550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0E00580	COG0302	gtp cyclohydrolase
HG535_0E00590	COG0515	serine threonine protein kinase
HG535_0E00590	COG1357	PFAM Pentapeptide repeats (8 copies)
HG535_0E00620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG535_0E00620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG535_0E00750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HG535_0E00770	COG1902	pentaerythritol trinitrate reductase activity
HG535_0E00810	COG0148	phosphopyruvate hydratase activity
HG535_0E00850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG535_0E00890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0E00940	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HG535_0E01010	COG0045	succinate-CoA ligase (ADP-forming) activity
HG535_0E01040	COG0205	6-phosphofructokinase activity
HG535_0E01270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG535_0E01280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG535_0E01350	COG0513	Belongs to the DEAD box helicase family
HG535_0E01540	COG0626	cystathionine gamma-synthase activity
HG535_0E01620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG535_0E01880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG535_0E01930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG535_0E02090	COG2814	Major facilitator Superfamily
HG535_0E02100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG535_0E02110	COG1063	alcohol dehydrogenase
HG535_0E02130	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0E02310	COG0509	glycine decarboxylation via glycine cleavage system
HG535_0E02390	COG0644	oxidoreductase
HG535_0E02390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HG535_0E02510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG535_0E02540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0E02550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG535_0E02550	COG3266	domain, Protein
HG535_0E02560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG535_0E02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG535_0E02760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG535_0E02850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0E03010	COG0626	cystathionine gamma-synthase activity
HG535_0E03040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG535_0E03050	COG1196	nuclear chromosome segregation
HG535_0E03220	COG0515	serine threonine protein kinase
HG535_0E03230	COG0427	acetyl-CoA hydrolase
HG535_0E03260	COG0167	dihydroorotate dehydrogenase activity
HG535_0E03290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG535_0E03330	COG0006	proline dipeptidase activity
HG535_0E03390	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0E03450	COG0217	transcriptional regulatory protein
HG535_0E03480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG535_0E03550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG535_0E03570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG535_0E03780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG535_0E03870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG535_0E03970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG535_0E04000	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HG535_0E04010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HG535_0E04120	COG0133	tryptophan synthase activity
HG535_0E04180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG535_0E04210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG535_0E04230	COG2814	Major facilitator Superfamily
HG535_0E04300	COG0024	Methionine aminopeptidase
HG535_0E04500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG535_0E04560	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HG535_0E04570	COG3474	cytochrome
HG535_0E04590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG535_0E04650	COG1053	succinate dehydrogenase
HG535_0E04780	COG2814	Major facilitator Superfamily
HG535_0E04820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG535_0E04830	COG0085	RNA polymerase activity
HG535_0E04830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG535_0E04840	COG4285	Biotin-protein ligase, N terminal
HG535_0E04850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG535_0E04860	COG0459	protein refolding
HG535_0E05020	COG0515	serine threonine protein kinase
HG535_0E05090	COG1793	dna ligase
HG535_0E05150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HG535_0E05270	COG0481	GTPase activity
HG535_0E05430	COG0724	RNA recognition motif
HG535_0E05440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG535_0E05500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HG535_0E05560	COG2814	Major facilitator Superfamily
HG535_0E05570	COG0316	Belongs to the HesB IscA family
HG535_0E05580	COG0542	response to heat
HG535_0E05610	COG0443	Heat shock 70 kDa protein
HG535_0E05710	COG0017	Asparaginyl-tRNA synthetase
HG535_0E05780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG535_0E05800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0E05840	COG2873	o-acetylhomoserine
HG535_0F00250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG535_0F00260	COG0515	serine threonine protein kinase
HG535_0F00400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG535_0F00670	COG0076	glutamate decarboxylase activity
HG535_0F00720	COG1022	Amp-dependent synthetase and ligase
HG535_0F00770	COG1230	cation diffusion facilitator family transporter
HG535_0F00890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG535_0F00930	COG0505	Belongs to the CarA family
HG535_0F01030	COG0328	RNA-DNA hybrid ribonuclease activity
HG535_0F01160	COG4221	oxidoreductase activity
HG535_0F01550	COG0047	phosphoribosylformylglycinamidine synthase activity
HG535_0F01550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG535_0F01650	COG0443	Heat shock 70 kDa protein
HG535_0F01750	COG0515	serine threonine protein kinase
HG535_0F01750	COG2815	serine threonine protein kinase
HG535_0F01880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG535_0F01920	COG1073	alpha beta
HG535_0F01940	COG2814	Major facilitator Superfamily
HG535_0F02140	COG0670	Belongs to the BI1 family
HG535_0F02150	COG0039	L-malate dehydrogenase activity
HG535_0F02200	COG1914	H( )-stimulated, divalent metal cation uptake system
HG535_0F02360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG535_0F02380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG535_0F02450	COG0842	Transport permease protein
HG535_0F02450	COG1131	(ABC) transporter
HG535_0F02450	COG1716	ATPase activity
HG535_0F02540	COG0484	heat shock protein binding
HG535_0F02720	COG0489	protein tyrosine kinase activity
HG535_0F02800	COG0477	Major facilitator Superfamily
HG535_0F02820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG535_0F02840	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HG535_0F02850	COG1085	galactose-1-phosphate uridylyltransferase
HG535_0F02860	COG0033	Phosphoglucomutase
HG535_0F02950	COG1643	Atp-dependent helicase
HG535_0F02980	COG0318	PFAM AMP-dependent synthetase and ligase
HG535_0F03000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0F03030	COG0756	dUTP diphosphatase activity
HG535_0F03110	COG0307	riboflavin synthase, alpha
HG535_0F03150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HG535_0F03160	COG1196	nuclear chromosome segregation
HG535_0F03360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0F03370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG535_0F03370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG535_0F03400	COG0515	serine threonine protein kinase
HG535_0F03400	COG2815	serine threonine protein kinase
HG535_0F03490	COG0484	heat shock protein binding
HG535_0F03560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG535_0F03590	COG0527	aspartate kinase activity
HG535_0F03660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG535_0F03680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG535_0F03720	COG0251	oxidation-reduction process
HG535_0F03750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG535_0F03760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG535_0F03840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG535_0F03890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG535_0F03890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG535_0F03900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG535_0F03930	COG0251	oxidation-reduction process
HG535_0F03980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG535_0F04210	COG0612	Peptidase, M16
HG535_0F04250	COG0564	pseudouridine synthase activity
HG535_0F04500	COG0237	dephospho-CoA kinase activity
HG535_0F04530	COG0321	lipoyl(octanoyl) transferase activity
HG535_0F04590	COG1230	cation diffusion facilitator family transporter
HG535_0F04600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG535_0F04630	COG3844	kynureninase activity
HG535_0F04650	COG1213	nucleotidyl transferase
HG535_0F04670	COG0459	protein refolding
HG535_0F04870	COG0563	adenylate kinase activity
HG535_0F04920	COG2814	Major facilitator Superfamily
HG535_0F04930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HG535_0F04940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG535_0F05000	COG0156	8-amino-7-oxononanoate synthase activity
HG535_0F05020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG535_0F05030	COG0181	hydroxymethylbilane synthase activity
HG535_0F05080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG535_0F05150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG535_0F05280	COG1506	peptidase
HG535_0F05280	COG4946	Tricorn protease homolog
HG535_0F05280	COG0823	Involved in the tonB-independent uptake of proteins
HG535_0F05370	COG0822	iron-sulfur transferase activity
HG535_0F05500	COG1648	precorrin-2 dehydrogenase activity
HG535_0F05500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG535_0F05540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG535_0F05630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG535_0F05650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG535_0F05650	COG2857	Cytochrome c1
HG535_0F05660	COG0435	Glutathione S-transferase
HG535_0F05700	COG1234	tRNA 3'-trailer cleavage
HG535_0F05770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HG535_0F05790	COG2895	sulfate adenylyltransferase (ATP) activity
HG535_0F05820	COG1643	Atp-dependent helicase
HG535_0F05860	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0F05970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG535_0F06000	COG5002	protein histidine kinase activity
HG535_0F06000	COG0784	Response regulator, receiver
HG535_0F06000	COG2205	protein histidine kinase activity
HG535_0F06080	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG535_0F06120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG535_0F06190	COG0183	Belongs to the thiolase family
HG535_0F06260	COG2814	Major facilitator Superfamily
HG535_0F06290	COG2814	Major facilitator Superfamily
HG535_0F06340	COG0154	amidase activity
HG535_0G00130	COG0667	Aldo Keto reductase
HG535_0G00140	COG0667	Aldo Keto reductase
HG535_0G00150	COG2814	Major facilitator Superfamily
HG535_0G00160	COG0246	Mannitol dehydrogenase
HG535_0G00300	COG0724	RNA recognition motif
HG535_0G00330	COG0688	phosphatidylethanolamine metabolic process
HG535_0G00340	COG2131	deaminase
HG535_0G00350	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG535_0G00420	COG0481	GTPase activity
HG535_0G00460	COG0515	serine threonine protein kinase
HG535_0G00490	COG0004	ammonium transporteR
HG535_0G00530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HG535_0G00540	COG0515	serine threonine protein kinase
HG535_0G00540	COG3266	domain, Protein
HG535_0G00660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG535_0G00770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG535_0G00830	COG1444	tRNA N-acetyltransferase activity
HG535_0G00970	COG0187	DNA topoisomerase II activity
HG535_0G01130	COG0443	Heat shock 70 kDa protein
HG535_0G01200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG535_0G01200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG535_0G01390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG535_0G01450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG535_0G01500	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HG535_0G01540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG535_0G01610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG535_0G01630	COG0277	FAD linked oxidase domain protein
HG535_0G01640	COG0656	L-ascorbic acid biosynthetic process
HG535_0G01690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG535_0G01730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG535_0G01780	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG535_0G01850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG535_0G01860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG535_0G01870	COG0626	cystathionine gamma-synthase activity
HG535_0G01930	COG0515	serine threonine protein kinase
HG535_0G01930	COG2815	serine threonine protein kinase
HG535_0G02020	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG535_0G02130	COG0724	RNA recognition motif
HG535_0G02170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0G02180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG535_0G02210	COG0405	Gamma-glutamyltransferase
HG535_0G02220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG535_0G02300	COG0481	GTPase activity
HG535_0G02320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG535_0G02400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG535_0G02430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG535_0G02500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG535_0G02640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG535_0G02680	COG0459	protein refolding
HG535_0G02920	COG1741	Belongs to the pirin family
HG535_0G03030	COG0114	fumarate hydratase activity
HG535_0G03050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG535_0G03110	COG1132	(ABC) transporter
HG535_0G03160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG535_0G03170	COG0833	amino acid
HG535_0G03210	COG1621	beta-fructofuranosidase activity
HG535_0G03230	COG0523	cobalamin synthesis protein
HG535_0G03250	COG1454	alcohol dehydrogenase
HG535_0G03390	COG0564	pseudouridine synthase activity
HG535_0G03450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG535_0G03560	COG2124	cytochrome p450
HG535_0G03640	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG535_0G03790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG535_0G03870	COG0519	Catalyzes the synthesis of GMP from XMP
HG535_0G03870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG535_0G04030	COG1132	(ABC) transporter
HG535_0G04040	COG2815	serine threonine protein kinase
HG535_0G04040	COG0515	serine threonine protein kinase
HG535_0G04190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG535_0G04270	COG0515	serine threonine protein kinase
HG535_0G04270	COG2815	serine threonine protein kinase
HG535_0G04320	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HG535_0G04340	COG2814	Major facilitator Superfamily
HG535_0G04380	COG0081	regulation of translation
HG535_0G04390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HG535_0G04420	COG0484	heat shock protein binding
HG535_0G04470	COG1196	nuclear chromosome segregation
HG535_0G04490	COG1069	ribulokinase activity
HG535_0G04590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG535_0G04640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG535_0G04690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG535_0G04710	COG0617	tRNA 3'-terminal CCA addition
HG535_0G04780	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG535_0G04810	COG0484	heat shock protein binding
HG535_0G04880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG535_0G04900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG535_0G04960	COG0157	Belongs to the NadC ModD family
HG535_0G05020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG535_0G05070	COG5212	phosphodiesterase
HG535_0G05080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HG535_0G05120	COG0248	Ppx GppA phosphatase
HG535_0G05150	COG2814	Major facilitator Superfamily
HG535_0G05160	COG2814	Major facilitator Superfamily
HG535_0G05180	COG0154	amidase activity
HG535_0G05220	COG1028	Short-chain dehydrogenase reductase Sdr
HG535_0G05260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG535_0G05350	COG0459	protein refolding
HG535_0G05390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG535_0G05420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG535_0G05480	COG0667	Aldo Keto reductase
HG535_0G05500	COG1132	(ABC) transporter
HG535_0G05630	COG2814	Major facilitator Superfamily
HG535_0G05640	COG0833	amino acid
HG535_0G05660	COG0833	amino acid
HG535_0H00120	COG1012	belongs to the aldehyde dehydrogenase family
HG535_0H00130	COG0154	amidase activity
HG535_0H00140	COG0667	Aldo Keto reductase
HG535_0H00160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG535_0H00170	COG0656	L-ascorbic acid biosynthetic process
HG535_0H00190	COG0563	adenylate kinase activity
HG535_0H00240	COG0666	response to abiotic stimulus
HG535_0H00300	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HG535_0H00410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG535_0H00450	COG0039	L-malate dehydrogenase activity
HG535_0H00600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG535_0H00660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG535_0H00730	COG0588	phosphoglycerate mutase activity
HG535_0H00790	COG0833	amino acid
HG535_0H00800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG535_0H00830	COG0459	protein refolding
HG535_0H00860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG535_0H00910	COG0515	serine threonine protein kinase
HG535_0H00910	COG2815	serine threonine protein kinase
HG535_0H00980	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG535_0H00990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG535_0H01050	COG2815	serine threonine protein kinase
HG535_0H01050	COG0515	serine threonine protein kinase
HG535_0H01060	COG0475	glutathione-regulated potassium exporter activity
HG535_0H01080	COG0210	DNA helicase
HG535_0H01130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG535_0H01280	COG1196	nuclear chromosome segregation
HG535_0H01300	COG0484	heat shock protein binding
HG535_0H01450	COG0450	alkyl hydroperoxide reductase
HG535_0H01490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG535_0H01560	COG0443	Heat shock 70 kDa protein
HG535_0H01570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG535_0H01620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG535_0H01640	COG0443	Heat shock 70 kDa protein
HG535_0H01660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG535_0H01700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG535_0H01780	COG0659	secondary active sulfate transmembrane transporter activity
HG535_0H01790	COG0006	proline dipeptidase activity
HG535_0H01870	COG0101	tRNA pseudouridine synthase activity
HG535_0H01880	COG0513	Belongs to the DEAD box helicase family
HG535_0H01960	COG0228	four-way junction DNA binding
HG535_0H02010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG535_0H02060	COG1196	nuclear chromosome segregation
HG535_0H02140	COG0484	heat shock protein binding
HG535_0H02190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG535_0H02300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG535_0H02360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG535_0H02420	COG0542	response to heat
HG535_0H02560	COG0180	Tryptophanyl-tRNA synthetase
HG535_0H02590	COG2217	Heavy metal translocating P-type atpase
HG535_0H02680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG535_0H02710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG535_0H02810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG535_0H02830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG535_0H02890	COG0443	Heat shock 70 kDa protein
HG535_0H03070	COG1902	pentaerythritol trinitrate reductase activity
HG535_0H03090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG535_0H03190	COG0656	L-ascorbic acid biosynthetic process
HG535_0H03200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG535_0H03240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG535_0H03240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG535_0H03260	COG0210	DNA helicase
HG535_0H03280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG535_0H03310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG535_0H03310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG535_0H03420	COG2814	Major facilitator Superfamily
HG535_0H03490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG535_0H03750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG535_0H03800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG535_0H03940	COG0489	protein tyrosine kinase activity
HG535_0H03990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG535_0H04120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG535_0H04150	COG0460	homoserine dehydrogenase
HG535_0H04150	COG0527	aspartate kinase activity
HG535_0H04250	COG0515	serine threonine protein kinase
HG535_0H04250	COG2815	serine threonine protein kinase
HG535_0H04300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family