locus-tag	class	description
LB319_00015	COG2070	2-Nitropropane dioxygenase
LB319_00070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LB319_00090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LB319_00100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LB319_00125	COG0525	valine-tRNA ligase activity
LB319_00130	COG0113	porphobilinogen synthase activity
LB319_00145	COG3180	Ammonia monooxygenase
LB319_00150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LB319_00155	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LB319_00160	COG1902	pentaerythritol trinitrate reductase activity
LB319_00165	COG3180	Ammonia monooxygenase
LB319_00170	COG1335	isochorismatase
LB319_00185	COG0612	Peptidase, M16
LB319_00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LB319_00210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LB319_00215	COG1862	Preprotein translocase
LB319_00225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LB319_00230	COG0416	fatty acid biosynthetic process
LB319_00235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LB319_00250	COG0181	hydroxymethylbilane synthase activity
LB319_00255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LB319_00260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LB319_00265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LB319_00270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LB319_00285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LB319_00290	COG0193	aminoacyl-tRNA hydrolase activity
LB319_00295	COG0012	GTP binding
LB319_00300	COG0189	ligase activity
LB319_00310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LB319_00310	COG4106	trans-aconitate 2-methyltransferase activity
LB319_00320	COG0156	8-amino-7-oxononanoate synthase activity
LB319_00325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LB319_00350	COG1368	sulfuric ester hydrolase activity
LB319_00360	COG0826	peptidase U32
LB319_00365	COG0616	signal peptide processing
LB319_00370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LB319_00375	COG0459	protein refolding
LB319_00385	COG4804	nuclease activity
LB319_00390	COG2003	Belongs to the UPF0758 family
LB319_00465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LB319_00470	COG0384	phenazine biosynthesis protein PhzF
LB319_00485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LB319_00490	COG2249	NAD(P)H dehydrogenase (quinone) activity
LB319_00495	COG0436	Aminotransferase
LB319_00515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LB319_00535	COG0281	malic enzyme
LB319_00540	COG0497	DNA recombination
LB319_00545	COG0438	transferase activity, transferring glycosyl groups
LB319_00545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LB319_00570	COG5002	protein histidine kinase activity
LB319_00575	COG0372	Belongs to the citrate synthase family
LB319_00580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LB319_00585	COG2333	competence protein COMEC
LB319_00585	COG0658	competence protein
LB319_00605	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LB319_00610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LB319_00620	COG0583	DNA-binding transcription factor activity
LB319_00635	COG0477	Major facilitator Superfamily
LB319_00650	COG0357	Ribosomal RNA small subunit methyltransferase G
LB319_00655	COG0445	tRNA wobble uridine modification
LB319_00660	COG3386	PFAM SMP-30 Gluconolaconase
LB319_00665	COG0667	Aldo Keto reductase
LB319_00675	COG4771	TonB-dependent receptor
LB319_00680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LB319_00685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LB319_00700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LB319_00710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LB319_00720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LB319_00735	COG0175	sulfate reduction
LB319_00740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LB319_00740	COG1648	precorrin-2 dehydrogenase activity
LB319_00745	COG0175	sulfate reduction
LB319_00750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LB319_00755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LB319_00770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LB319_00775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LB319_00780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LB319_00785	COG1420	regulation of RNA biosynthetic process
LB319_00790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LB319_00800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LB319_00815	COG1139	Iron-sulfur cluster binding protein
LB319_00820	COG0247	lactate metabolic process
LB319_00840	COG0138	bifunctional purine biosynthesis protein purh
LB319_00845	COG1715	Restriction endonuclease
LB319_00865	COG2983	Belongs to the UPF0260 family
LB319_00880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LB319_00885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LB319_00890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LB319_00895	COG0237	dephospho-CoA kinase activity
LB319_00905	COG0424	maF-like protein
LB319_00925	COG2807	transmembrane transport
LB319_00930	COG0596	Alpha beta hydrolase
LB319_00935	COG1846	Transcriptional regulator
LB319_00940	COG0730	response to heat
LB319_00945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LB319_00955	COG1929	Belongs to the glycerate kinase type-1 family
LB319_00990	COG2999	glutathione oxidoreductase activity
LB319_01005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LB319_01010	COG1702	phosphate starvation-inducible protein PhoH
LB319_01015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LB319_01020	COG0835	chemotaxis
LB319_01025	COG0745	RESPONSE REGULATOR receiver
LB319_01030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LB319_01035	COG2201	protein-glutamate methylesterase activity
LB319_01040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LB319_01045	COG0643	Histidine kinase
LB319_01045	COG2198	Histidine kinase
LB319_01055	COG0840	transmembrane signaling receptor activity
LB319_01080	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_01090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LB319_01100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LB319_01125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LB319_01130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LB319_01135	COG0066	3-isopropylmalate dehydratase activity
LB319_01160	COG0488	(ABC) transporter
LB319_01170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LB319_01175	COG0512	Glutamine amidotransferase of anthranilate synthase
LB319_01175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LB319_01180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LB319_01185	COG1959	2 iron, 2 sulfur cluster binding
LB319_01190	COG1151	hydroxylamine reductase activity
LB319_01195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LB319_01205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LB319_01220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LB319_01240	COG0671	phosphoesterase, PA-phosphatase related
LB319_01295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LB319_01305	COG1131	(ABC) transporter
LB319_01325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LB319_01335	COG0469	pyruvate kinase activity
LB319_01340	COG3750	Belongs to the UPF0335 family
LB319_01345	COG0217	transcriptional regulatory protein
LB319_01350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LB319_01355	COG0632	four-way junction helicase activity
LB319_01365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LB319_01370	COG2255	four-way junction helicase activity
LB319_01375	COG0824	Thioesterase
LB319_01380	COG0811	peptide transport
LB319_01385	COG0848	biopolymer transport protein
LB319_01395	COG0823	Involved in the tonB-independent uptake of proteins
LB319_01400	COG2885	chlorophyll binding
LB319_01415	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_01420	COG0789	Transcriptional regulator
LB319_01440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LB319_01465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LB319_01470	COG0126	phosphoglycerate kinase activity
LB319_01480	COG1830	Aldolase
LB319_01485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LB319_01490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LB319_01495	COG0488	(ABC) transporter
LB319_01505	COG0215	cysteine-tRNA ligase activity
LB319_01510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LB319_01525	COG1760	l-serine dehydratase
LB319_01545	COG1530	ribonuclease E activity
LB319_01555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LB319_01565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LB319_01570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LB319_01580	COG0840	transmembrane signaling receptor activity
LB319_01585	COG0789	Transcriptional regulator
LB319_01600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LB319_01605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LB319_01615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LB319_01620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LB319_01630	COG0534	Mate efflux family protein
LB319_01640	COG0739	heme binding
LB319_01645	COG4581	dead DEAH box helicase
LB319_01650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LB319_01655	COG1329	Transcriptional regulator
LB319_01670	COG2813	Specifically methylates the guanine in position
LB319_01670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LB319_01675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LB319_01680	COG4221	oxidoreductase activity
LB319_01685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LB319_01685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LB319_01695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LB319_01700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LB319_01710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LB319_01725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LB319_01730	COG0489	protein tyrosine kinase activity
LB319_01735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LB319_01740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LB319_01745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LB319_01750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LB319_01755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LB319_01765	COG0776	regulation of translation
LB319_01770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LB319_01775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LB319_01780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LB319_01810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LB319_01815	COG0277	FAD linked oxidase domain protein
LB319_01830	COG4133	protoheme IX ABC transporter activity
LB319_01835	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LB319_01885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LB319_01890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LB319_01895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LB319_01900	COG1137	ATPase activity
LB319_01925	COG1278	Cold shock
LB319_01935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LB319_01960	COG2733	membrane
LB319_01965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LB319_01970	COG2814	Major facilitator Superfamily
LB319_01975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LB319_01980	COG0590	tRNA wobble adenosine to inosine editing
LB319_01985	COG1253	flavin adenine dinucleotide binding
LB319_01995	COG0151	Belongs to the GarS family
LB319_02000	COG1570	exodeoxyribonuclease VII activity
LB319_02015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LB319_02035	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_02045	COG1473	amidohydrolase
LB319_02055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LB319_02065	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_02085	COG0196	riboflavin kinase activity
LB319_02090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LB319_02095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LB319_02105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LB319_02115	COG0626	cystathionine gamma-synthase activity
LB319_02120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LB319_02125	COG0483	inositol monophosphate 1-phosphatase activity
LB319_02130	COG3108	Peptidase M15
LB319_02135	COG0352	thiamine-phosphate diphosphorylase activity
LB319_02140	COG2894	cell division
LB319_02160	COG0436	Aminotransferase
LB319_02170	COG0312	modulator of DNA gyrase
LB319_02180	COG0004	ammonium transporteR
LB319_02185	COG1923	regulation of RNA biosynthetic process
LB319_02190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LB319_02195	COG1678	Uncharacterized ACR, COG1678
LB319_02220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LB319_02245	COG0772	Belongs to the SEDS family
LB319_02255	COG0556	nucleotide-excision repair
LB319_02260	COG0343	queuine tRNA-ribosyltransferase activity
LB319_02265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LB319_02270	COG0477	Major facilitator Superfamily
LB319_02275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LB319_02280	COG0129	dihydroxy-acid dehydratase activity
LB319_02285	COG0837	glucose binding
LB319_02290	COG1794	racemase activity, acting on amino acids and derivatives
LB319_02295	COG1522	sequence-specific DNA binding
LB319_02305	COG1621	beta-fructofuranosidase activity
LB319_02310	COG1621	beta-fructofuranosidase activity
LB319_02425	COG5001	Diguanylate cyclase
LB319_02430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LB319_02435	COG0248	Ppx GppA phosphatase
LB319_02450	COG0842	Transport permease protein
LB319_02460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LB319_02465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LB319_02475	COG0187	DNA topoisomerase II activity
LB319_02480	COG2095	MarC family integral membrane protein
LB319_02495	COG2884	Cell division ATP-binding protein ftsE
LB319_02515	COG0287	Prephenate dehydrogenase
LB319_02520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LB319_02530	COG0719	Fe-S assembly protein
LB319_02535	COG0396	ATPase activity
LB319_02540	COG0719	Fe-S assembly protein
LB319_02545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LB319_02550	COG2151	metal-sulfur cluster biosynthetic enzyme
LB319_02555	COG0316	Belongs to the HesB IscA family
LB319_02565	COG2171	N-acyltransferase activity
LB319_02575	COG0194	GDP metabolic process
LB319_02610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LB319_02615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LB319_02615	COG1372	Participates in initiation and elongation during chromosome replication
LB319_02630	COG1696	Membrane protein involved in D-alanine export
LB319_02660	COG1160	GTP binding
LB319_02665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LB319_02675	COG1522	sequence-specific DNA binding
LB319_02680	COG1136	(ABC) transporter
LB319_02690	COG0442	prolyl-tRNA aminoacylation
LB319_02695	COG0504	CTP synthase activity
LB319_02705	COG0149	triose-phosphate isomerase activity
LB319_02715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LB319_02725	COG0583	DNA-binding transcription factor activity
LB319_02735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LB319_02750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LB319_02750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LB319_02770	COG5002	protein histidine kinase activity
LB319_02780	COG1494	fructose-1,6-bisphosphatase
LB319_02795	COG1960	acyl-CoA dehydrogenase activity
LB319_02800	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LB319_02825	COG0006	proline dipeptidase activity
LB319_02830	COG0347	Belongs to the P(II) protein family
LB319_02835	COG0174	glutamine synthetase
LB319_02855	COG0546	phosphoglycolate phosphatase activity
LB319_02860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LB319_02865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LB319_02885	COG0463	Glycosyl transferase, family 2
LB319_02890	COG0564	pseudouridine synthase activity
LB319_02900	COG1956	GAF domain-containing protein
LB319_02915	COG0508	dehydrogenase complex catalyzes the overall conversion of
LB319_02920	COG1607	acyl-coa hydrolase
LB319_02925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LB319_02930	COG0671	phosphoesterase, PA-phosphatase related
LB319_02935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LB319_02940	COG0049	tRNA binding
LB319_02945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LB319_02950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LB319_02955	COG0051	transcription antitermination factor activity, RNA binding
LB319_02960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LB319_02965	COG0088	Forms part of the polypeptide exit tunnel
LB319_02970	COG0089	rRNA binding
LB319_02975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LB319_02980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LB319_02985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LB319_02990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LB319_02995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LB319_03000	COG0255	Belongs to the universal ribosomal protein uL29 family
LB319_03005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LB319_03010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LB319_03015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LB319_03020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LB319_03025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LB319_03030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LB319_03035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LB319_03040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LB319_03045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LB319_03050	COG1841	ribosomal large subunit assembly
LB319_03055	COG0200	Binds to the 23S rRNA
LB319_03060	COG0201	protein transport
LB319_03065	COG0563	adenylate kinase activity
LB319_03070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LB319_03075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LB319_03080	COG0202	RNA polymerase activity
LB319_03085	COG0203	ribosomal protein L17
LB319_03095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LB319_03100	COG0538	isocitrate dehydrogenase activity
LB319_03105	COG0134	indole-3-glycerol-phosphate synthase activity
LB319_03110	COG0659	secondary active sulfate transmembrane transporter activity
LB319_03120	COG0038	chloride channel
LB319_03130	COG1185	polyribonucleotide nucleotidyltransferase activity
LB319_03135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LB319_03140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LB319_03145	COG1435	thymidine kinase activity
LB319_03150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LB319_03155	COG3064	Membrane
LB319_03155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LB319_03170	COG0779	Required for maturation of 30S ribosomal subunits
LB319_03175	COG2133	pyrroloquinoline quinone binding
LB319_03185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LB319_03190	COG4771	TonB-dependent receptor
LB319_03195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LB319_03200	COG1605	Chorismate mutase
LB319_03200	COG0287	Prephenate dehydrogenase
LB319_03205	COG0142	geranyltranstransferase activity
LB319_03210	COG1643	Atp-dependent helicase
LB319_03215	COG2814	Major facilitator Superfamily
LB319_03235	COG2264	protein methyltransferase activity
LB319_03245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LB319_03250	COG1116	anion transmembrane transporter activity
LB319_03255	COG2999	glutathione oxidoreductase activity
LB319_03265	COG0742	ribosomal rna small subunit methyltransferase
LB319_03270	COG1187	pseudouridine synthase activity
LB319_03275	COG1301	dicarboxylic acid transport
LB319_03280	COG2223	nitrite transmembrane transporter activity
LB319_03285	COG0285	dihydrofolate synthase activity
LB319_03290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LB319_03295	COG0159	tryptophan synthase activity
LB319_03300	COG0133	tryptophan synthase activity
LB319_03305	COG0135	phosphoribosylanthranilate isomerase activity
LB319_03310	COG0284	orotidine-5'-phosphate decarboxylase activity
LB319_03325	COG1286	toxin biosynthetic process
LB319_03340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LB319_03345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LB319_03360	COG4974	Belongs to the 'phage' integrase family
LB319_03365	COG0825	malonyl-CoA metabolic process
LB319_03400	COG1706	bacterial-type flagellum-dependent cell motility
LB319_03405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LB319_03420	COG1749	Flagellar hook protein flgE
LB319_03425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LB319_03430	COG1558	bacterial-type flagellum-dependent cell motility
LB319_03440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LB319_03470	COG0455	bacterial-type flagellum organization
LB319_03500	COG1677	Flagellar hook-basal body complex protein FliE
LB319_03510	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LB319_03545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LB319_03565	COG1987	bacterial-type flagellum assembly
LB319_03570	COG1684	flagellar biosynthetic protein fliR
LB319_03575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LB319_03590	COG0628	permease
LB319_03595	COG0726	polysaccharide deacetylase
LB319_03610	COG3138	arginine N-succinyltransferase
LB319_03625	COG0443	Heat shock 70 kDa protein
LB319_03630	COG0484	heat shock protein binding
LB319_03635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LB319_03640	COG2003	Belongs to the UPF0758 family
LB319_03665	COG0356	it plays a direct role in the translocation of protons across the membrane
LB319_03675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LB319_03680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LB319_03685	COG0322	excinuclease ABC activity
LB319_03690	COG1381	Involved in DNA repair and RecF pathway recombination
LB319_03700	COG0583	DNA-binding transcription factor activity
LB319_03710	COG0473	3-isopropylmalate dehydrogenase activity
LB319_03760	COG0679	Auxin Efflux Carrier
LB319_03765	COG0673	inositol 2-dehydrogenase activity
LB319_03770	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LB319_03775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LB319_03780	COG1764	response to oxidative stress
LB319_03805	COG2076	Multidrug Resistance protein
LB319_03825	COG0318	PFAM AMP-dependent synthetase and ligase
LB319_03840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LB319_03845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LB319_03850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LB319_03865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LB319_03870	COG0248	Ppx GppA phosphatase
LB319_03875	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LB319_03880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LB319_03885	COG2326	polyphosphate kinase activity
LB319_03895	COG0741	lytic transglycosylase activity
LB319_03900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LB319_03905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LB319_03910	COG3590	peptidase
LB319_03920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LB319_03930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LB319_03935	COG0081	regulation of translation
LB319_03940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LB319_03945	COG0222	ribosome binding
LB319_03955	COG0085	RNA polymerase activity
LB319_03960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LB319_03980	COG0439	Biotin carboxylase
LB319_03985	COG0511	ligase activity, forming carbon-carbon bonds
LB319_03990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LB319_04000	COG2022	thiamine diphosphate biosynthetic process
LB319_04005	COG2329	Antibiotic biosynthesis monooxygenase
LB319_04015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LB319_04050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LB319_04055	COG0564	pseudouridine synthase activity
LB319_04070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LB319_04095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LB319_04115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LB319_04120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LB319_04135	COG0482	sulfurtransferase activity
LB319_04140	COG2239	Acts as a magnesium transporter
LB319_04160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LB319_04175	COG1538	Outer membrane efflux protein
LB319_04180	COG0583	DNA-binding transcription factor activity
LB319_04185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LB319_04190	COG0154	amidase activity
LB319_04195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LB319_04200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LB319_04230	COG0540	Belongs to the ATCase OTCase family
LB319_04235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LB319_04245	COG1505	serine-type exopeptidase activity
LB319_04255	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_04265	COG0842	Transport permease protein
LB319_04270	COG0842	Transport permease protein
LB319_04270	COG1129	ABC transporter
LB319_04295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LB319_04300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LB319_04305	COG1872	DUF167
LB319_04310	COG0101	tRNA pseudouridine synthase activity
LB319_04315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LB319_04320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LB319_04325	COG0242	peptide deformylase activity
LB319_04330	COG1322	Protein conserved in bacteria
LB319_04345	COG0720	synthase
LB319_04350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LB319_04355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LB319_04370	COG0275	rRNA processing
LB319_04385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LB319_04395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LB319_04400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LB319_04410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LB319_04415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LB319_04420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LB319_04425	COG1181	Belongs to the D-alanine--D-alanine ligase family
LB319_04430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LB319_04435	COG0849	cell division
LB319_04440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LB319_04450	COG0038	chloride channel
LB319_04455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LB319_04460	COG0018	arginyl-trna synthetase
LB319_04470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LB319_04495	COG0259	pyridoxamine-phosphate oxidase activity
LB319_04500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LB319_04510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LB319_04515	COG0142	geranyltranstransferase activity
LB319_04520	COG1722	exodeoxyribonuclease VII activity
LB319_04530	COG1104	cysteine desulfurase activity
LB319_04545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LB319_04550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LB319_04555	COG0717	Belongs to the dCTP deaminase family
LB319_04560	COG0295	cytidine deaminase activity
LB319_04565	COG0305	Participates in initiation and elongation during chromosome replication
LB319_04575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LB319_04580	COG1215	transferase activity, transferring glycosyl groups
LB319_04585	COG1562	ergosterol biosynthetic process
LB319_04590	COG1562	ergosterol biosynthetic process
LB319_04595	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LB319_04600	COG1657	PFAM Prenyltransferase squalene oxidase
LB319_04615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LB319_04630	COG2201	protein-glutamate methylesterase activity
LB319_04635	COG2198	Histidine kinase
LB319_04635	COG0643	Histidine kinase
LB319_04640	COG0840	transmembrane signaling receptor activity
LB319_04645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LB319_04650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LB319_04675	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LB319_04680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LB319_04680	COG1199	ATP-dependent helicase activity
LB319_04715	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LB319_04715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LB319_04730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LB319_04740	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LB319_04780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LB319_04785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LB319_04790	COG2217	Heavy metal translocating P-type atpase
LB319_04830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LB319_04835	COG0653	protein targeting
LB319_04840	COG1278	Cold shock
LB319_04855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LB319_04860	COG3191	aminopeptidase activity
LB319_04890	COG0697	spore germination
LB319_04895	COG1448	Aminotransferase
LB319_04900	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
LB319_04905	COG0402	S-adenosylhomocysteine deaminase activity
LB319_04910	COG1846	Transcriptional regulator
LB319_04925	COG1621	beta-fructofuranosidase activity
LB319_04945	COG0544	peptidyl-prolyl cis-trans isomerase activity
LB319_04955	COG0740	serine-type endopeptidase activity
LB319_04960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LB319_04970	COG0408	coproporphyrinogen oxidase activity
LB319_04975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LB319_04990	COG3293	Transposase
LB319_04995	COG0723	plastoquinol--plastocyanin reductase activity
LB319_05000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LB319_05005	COG2857	Cytochrome c1
LB319_05020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LB319_05035	COG1566	PFAM secretion protein HlyD family protein
LB319_05040	COG2814	Major facilitator Superfamily
LB319_05045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LB319_05055	COG2252	PERMEase
LB319_05065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LB319_05095	COG0667	Aldo Keto reductase
LB319_05105	COG4206	TonB-dependent receptor
LB319_05115	COG4172	Belongs to the ABC transporter superfamily
LB319_05120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LB319_05135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LB319_05140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LB319_05160	COG0071	Belongs to the small heat shock protein (HSP20) family
LB319_05175	COG0668	transmembrane transport
LB319_05180	COG0800	Aldolase
LB319_05185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LB319_05190	COG0009	L-threonylcarbamoyladenylate synthase
LB319_05195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LB319_05200	COG3104	oligopeptide transport
LB319_05205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LB319_05210	COG0351	phosphomethylpyrimidine kinase
LB319_05210	COG0352	thiamine-phosphate diphosphorylase activity
LB319_05215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LB319_05225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LB319_05230	COG3781	membrane
LB319_05235	COG0277	FAD linked oxidase domain protein
LB319_05255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LB319_05265	COG0424	maF-like protein
LB319_05270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LB319_05285	COG1127	ABC transporter
LB319_05290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LB319_05300	COG0019	diaminopimelate decarboxylase activity
LB319_05305	COG2945	thiolester hydrolase activity
LB319_05310	COG1104	cysteine desulfurase activity
LB319_05315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LB319_05340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LB319_05345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LB319_05355	COG0137	argininosuccinate synthase activity
LB319_05365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LB319_05365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LB319_05385	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LB319_05395	COG1970	mechanosensitive ion channel activity
LB319_05405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LB319_05410	COG0573	inorganic phosphate transmembrane transporter activity
LB319_05415	COG0581	inorganic phosphate transmembrane transporter activity
LB319_05420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LB319_05425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LB319_05430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LB319_05435	COG5001	Diguanylate cyclase
LB319_05440	COG0617	tRNA 3'-terminal CCA addition
LB319_05460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LB319_05470	COG1842	Phage shock protein A
LB319_05500	COG0484	heat shock protein binding
LB319_05510	COG0552	protein localization to endoplasmic reticulum
LB319_05515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LB319_05520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LB319_05525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LB319_05530	COG0228	four-way junction DNA binding
LB319_05535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LB319_05540	COG0336	Belongs to the RNA methyltransferase TrmD family
LB319_05545	COG0335	large ribosomal subunit rRNA binding
LB319_05565	COG1215	transferase activity, transferring glycosyl groups
LB319_05570	COG1215	transferase activity, transferring glycosyl groups
LB319_05575	COG0457	Tetratricopeptide repeat
LB319_05580	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LB319_05585	COG2951	lytic endotransglycosylase activity
LB319_05595	COG1686	Belongs to the peptidase S11 family
LB319_05600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LB319_05605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LB319_05615	COG0084	hydrolase, TatD family'
LB319_05625	COG3956	TIGRFAM MazG family protein
LB319_05630	COG0557	exoribonuclease II activity
LB319_05640	COG1074	ATP-dependent DNA helicase activity
LB319_05650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LB319_05655	COG0802	atpase or kinase
LB319_05660	COG2205	protein histidine kinase activity
LB319_05675	COG1522	sequence-specific DNA binding
LB319_05685	COG2807	transmembrane transport
LB319_05690	COG2917	probably involved in intracellular septation
LB319_05695	COG1252	NADH dehydrogenase
LB319_05700	COG1573	uracil-dna glycosylase
LB319_05710	COG1968	undecaprenyl-diphosphatase activity
LB319_05735	COG0776	regulation of translation
LB319_05745	COG2204	response regulator
LB319_05750	COG5000	phosphorelay sensor kinase activity
LB319_05755	COG2204	response regulator
LB319_05765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LB319_05765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LB319_05775	COG1058	Belongs to the CinA family
LB319_05775	COG1546	Belongs to the CinA family
LB319_05780	COG2867	negative regulation of translational initiation
LB319_05785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LB319_05790	COG0288	reversible hydration of carbon dioxide
LB319_05800	COG0312	modulator of DNA gyrase
LB319_05805	COG1858	cytochrome C peroxidase
LB319_05815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LB319_05820	COG0028	Belongs to the TPP enzyme family
LB319_05825	COG0440	acetolactate synthase activity
LB319_05830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LB319_05835	COG0492	ferredoxin-NADP+ reductase activity
LB319_05850	COG0254	rRNA binding
LB319_05855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LB319_05865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LB319_05870	COG0750	zinc metalloprotease
LB319_05875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LB319_05880	COG0575	Belongs to the CDS family
LB319_05885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LB319_05890	COG0233	cytoplasmic translational termination
LB319_05895	COG0528	UMP kinase activity
LB319_05900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LB319_05905	COG0052	Belongs to the universal ribosomal protein uS2 family
LB319_05915	COG1794	racemase activity, acting on amino acids and derivatives
LB319_05920	COG1183	phosphatidylcholine synthase activity
LB319_05925	COG0688	phosphatidylethanolamine metabolic process
LB319_05935	COG0704	Plays a role in the regulation of phosphate uptake
LB319_05940	COG0745	RESPONSE REGULATOR receiver
LB319_05945	COG1040	competence protein
LB319_05950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LB319_05960	COG2971	BadF BadG BcrA BcrD
LB319_05970	COG1472	Belongs to the glycosyl hydrolase 3 family
LB319_05975	COG3724	N-succinylarginine dihydrolase activity
LB319_05990	COG2205	protein histidine kinase activity
LB319_06000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LB319_06005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LB319_06020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LB319_06045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LB319_06055	COG2226	methyltransferase
LB319_06060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LB319_06065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LB319_06070	COG0756	dUTP diphosphatase activity
LB319_06075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LB319_06080	COG1754	DNA topoisomerase type I activity
LB319_06080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LB319_06085	COG0758	DNA mediated transformation
LB319_06090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LB319_06095	COG2814	Major facilitator Superfamily
LB319_06100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LB319_06105	COG0156	8-amino-7-oxononanoate synthase activity
LB319_06115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LB319_06120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LB319_06145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LB319_06155	COG3158	transport of potassium into the cell
LB319_06170	COG0166	Belongs to the GPI family
LB319_06180	COG0513	Belongs to the DEAD box helicase family
LB319_06200	COG0805	protein transport
LB319_06205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LB319_06210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LB319_06225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LB319_06230	COG0360	Binds together with S18 to 16S ribosomal RNA
LB319_06235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LB319_06240	COG0359	binds to the 23S rRNA
LB319_06245	COG4948	Mandelate Racemase Muconate Lactonizing
LB319_06250	COG0302	gtp cyclohydrolase
LB319_06255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LB319_06255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LB319_06275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LB319_06285	COG1064	alcohol dehydrogenase
LB319_06290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LB319_06295	COG0588	phosphoglycerate mutase activity
LB319_06300	COG2866	Carboxypeptidase
LB319_06310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LB319_06335	COG3088	subunit of a heme lyase
LB319_06340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LB319_06345	COG1138	Cytochrome C-type biogenesis protein
LB319_06350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LB319_06360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LB319_06365	COG4771	TonB-dependent receptor
LB319_06370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LB319_06375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LB319_06380	COG1116	anion transmembrane transporter activity
LB319_06385	COG4948	Mandelate Racemase Muconate Lactonizing
LB319_06395	COG0519	Catalyzes the synthesis of GMP from XMP
LB319_06395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LB319_06410	COG0156	8-amino-7-oxononanoate synthase activity
LB319_06415	COG1648	precorrin-2 dehydrogenase activity
LB319_06415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LB319_06420	COG1012	belongs to the aldehyde dehydrogenase family
LB319_06430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LB319_06440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LB319_06445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LB319_06450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LB319_06475	COG0438	transferase activity, transferring glycosyl groups
LB319_06480	COG2223	nitrite transmembrane transporter activity
LB319_06485	COG2261	transglycosylase associated protein
LB319_06495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LB319_06500	COG0602	queuosine metabolic process
LB319_06545	COG0321	lipoyl(octanoyl) transferase activity
LB319_06550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LB319_06565	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LB319_06570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LB319_06570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LB319_06580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LB319_06585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LB319_06590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LB319_06595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LB319_06600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LB319_06610	COG2244	polysaccharide biosynthetic process
LB319_06615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LB319_06620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LB319_06630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LB319_06640	COG0745	RESPONSE REGULATOR receiver
LB319_06645	COG0642	Histidine kinase
LB319_06650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LB319_06655	COG1660	Displays ATPase and GTPase activities
LB319_06670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LB319_06675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LB319_06680	COG0668	transmembrane transport
LB319_06685	COG2353	YceI-like domain
LB319_06690	COG0655	NAD(P)H dehydrogenase (quinone) activity
LB319_06695	COG0583	DNA-binding transcription factor activity
LB319_06700	COG1741	Belongs to the pirin family
LB319_06705	COG1280	lysine exporter protein (LysE YggA)
LB319_06715	COG2321	neutral zinc metallopeptidase
LB319_06730	COG0308	aminopeptidase N
LB319_06745	COG0024	Methionine aminopeptidase
LB319_06750	COG1058	Belongs to the CinA family
LB319_06750	COG1546	Belongs to the CinA family
LB319_06760	COG0670	Belongs to the BI1 family
LB319_06765	COG4702	Belongs to the UPF0303 family
LB319_06770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LB319_06770	COG2885	chlorophyll binding
LB319_06775	COG0488	(ABC) transporter
LB319_06780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LB319_06785	COG0268	Binds directly to 16S ribosomal RNA
LB319_06790	COG3961	Belongs to the TPP enzyme family
LB319_06800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LB319_06810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LB319_06830	COG0300	oxidoreductase activity
LB319_06840	COG1090	epimerase
LB319_06845	COG0571	ribonuclease III activity
LB319_06875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LB319_06880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LB319_06900	COG0405	Gamma-glutamyltransferase
LB319_06960	COG0708	Exodeoxyribonuclease III
LB319_06965	COG0316	Belongs to the HesB IscA family
LB319_06970	COG0739	heme binding
LB319_06980	COG0784	Response regulator, receiver
LB319_06985	COG0596	Alpha beta hydrolase
LB319_06990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LB319_07010	COG2193	ferroxidase activity
LB319_07020	COG4957	zinc ion binding
LB319_07030	COG1214	PFAM Peptidase M22, glycoprotease
LB319_07040	COG0513	Belongs to the DEAD box helicase family
LB319_07050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LB319_07055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LB319_07060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LB319_07065	COG0612	Peptidase, M16
LB319_07070	COG0612	Peptidase, M16
LB319_07080	COG0352	thiamine-phosphate diphosphorylase activity
LB319_07085	COG2003	Belongs to the UPF0758 family
LB319_07090	COG1597	lipid kinase activity
LB319_07125	COG0495	leucyl-tRNA aminoacylation
LB319_07145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LB319_07165	COG2244	polysaccharide biosynthetic process
LB319_07175	COG0752	glycyl-tRNA synthetase alpha subunit
LB319_07195	COG0246	Mannitol dehydrogenase
LB319_07200	COG0415	Belongs to the DNA photolyase family
LB319_07210	COG2814	Major facilitator Superfamily
LB319_07215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LB319_07265	COG0814	amino acid
LB319_07290	COG1217	gtp-binding protein TYPA
LB319_07315	COG0363	glucosamine-6-phosphate deaminase activity
LB319_07330	COG0045	succinate-CoA ligase (ADP-forming) activity
LB319_07340	COG0210	DNA helicase
LB319_07355	COG2199	diguanylate cyclase activity
LB319_07355	COG2200	EAL domain
LB319_07360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LB319_07365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LB319_07390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LB319_07395	COG2096	Adenosyltransferase
LB319_07400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LB319_07405	COG0531	amino acid
LB319_07415	COG0140	phosphoribosyl-ATP diphosphatase activity
LB319_07420	COG0107	imidazoleglycerol-phosphate synthase activity
LB319_07425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LB319_07430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LB319_07435	COG0131	Imidazoleglycerol-phosphate dehydratase
LB319_07450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LB319_07455	COG0124	histidyl-tRNA synthetase
LB319_07460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LB319_07465	COG2890	protein-(glutamine-N5) methyltransferase activity
LB319_07475	COG5265	(ABC) transporter
LB319_07480	COG0072	phenylalanine-tRNA ligase activity
LB319_07480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LB319_07485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LB319_07490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LB319_07495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LB319_07505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LB319_07530	COG1538	Outer membrane efflux protein
LB319_07545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LB319_07550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LB319_07550	COG0517	IMP dehydrogenase activity
LB319_07555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LB319_07560	COG0047	phosphoribosylformylglycinamidine synthase activity
LB319_07600	COG0629	single-stranded DNA binding
LB319_07625	COG1657	PFAM Prenyltransferase squalene oxidase
LB319_07635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LB319_07640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LB319_07645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LB319_07650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LB319_07665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LB319_07670	COG4221	oxidoreductase activity
LB319_07675	COG1051	belongs to the nudix hydrolase family
LB319_07695	COG1742	UPF0060 membrane protein
LB319_07710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LB319_07720	COG1271	oxidase subunit
LB319_07725	COG1294	oxidase, subunit
LB319_07745	COG4221	oxidoreductase activity
LB319_07810	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LB319_07825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LB319_07835	COG1127	ABC transporter
LB319_07840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LB319_07845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LB319_07855	COG1454	alcohol dehydrogenase
LB319_07860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LB319_07870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LB319_07875	COG0328	RNA-DNA hybrid ribonuclease activity
LB319_07885	COG3453	Protein conserved in bacteria
LB319_07885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LB319_07895	COG0022	dehydrogenase e1 component
LB319_07895	COG0508	dehydrogenase complex catalyzes the overall conversion of
LB319_07900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LB319_07910	COG0148	phosphopyruvate hydratase activity
LB319_07940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LB319_07950	COG0505	Belongs to the CarA family
LB319_07965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LB319_07975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LB319_07980	COG0594	ribonuclease P activity
LB319_07985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LB319_07990	COG0706	membrane insertase activity
LB319_07995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LB319_08015	COG4774	siderophore transport
LB319_08020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LB319_08035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LB319_08050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LB319_08055	COG0728	peptidoglycan biosynthetic process
LB319_08060	COG0180	Tryptophanyl-tRNA synthetase
LB319_08075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LB319_08080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LB319_08090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LB319_08105	COG1573	uracil-dna glycosylase
LB319_08110	COG3386	PFAM SMP-30 Gluconolaconase
LB319_08120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LB319_08135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LB319_08155	COG0037	tRNA processing
LB319_08170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LB319_08175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LB319_08180	COG0799	negative regulation of ribosome biogenesis
LB319_08185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LB319_08195	COG0793	Belongs to the peptidase S41A family
LB319_08205	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LB319_08225	COG0656	L-ascorbic acid biosynthetic process
LB319_08240	COG1194	a g-specific adenine glycosylase
LB319_08245	COG0077	Prephenate dehydratase
LB319_08260	COG2985	domain, Protein
LB319_08270	COG0252	asparaginase activity
LB319_08280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LB319_08290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LB319_08295	COG0354	folic acid binding
LB319_08300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LB319_08305	COG0484	heat shock protein binding
LB319_08310	COG1295	ribonuclease BN
LB319_08315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LB319_08320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LB319_08340	COG1733	regulation of RNA biosynthetic process
LB319_08350	COG0708	Exodeoxyribonuclease III
LB319_08360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LB319_08365	COG1674	ftsk spoiiie
LB319_08370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LB319_08385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LB319_08390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LB319_08395	COG0736	holo-[acyl-carrier-protein] synthase activity
LB319_08400	COG0681	Belongs to the peptidase S26 family
LB319_08405	COG0628	permease
LB319_08415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LB319_08445	COG1940	carbohydrate kinase activity
LB319_08450	COG1758	RNA polymerase activity
LB319_08460	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LB319_08475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LB319_08480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LB319_08485	COG0436	Aminotransferase
LB319_08500	COG1045	serine acetyltransferase
LB319_08510	COG0583	DNA-binding transcription factor activity
LB319_08525	COG3279	Response regulator of the LytR AlgR family
LB319_08530	COG3275	phosphorelay sensor kinase activity
LB319_08540	COG0481	GTPase activity
LB319_08550	COG1410	methionine synthase
LB319_08550	COG0646	methionine synthase
LB319_08570	COG2853	Lipoprotein
LB319_08595	COG1012	belongs to the aldehyde dehydrogenase family
LB319_08600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LB319_08605	COG2610	gluconate transmembrane transporter activity
LB319_08610	COG3265	gluconokinase activity
LB319_08615	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LB319_08630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LB319_08635	COG0792	nuclease activity
LB319_08645	COG2989	Protein conserved in bacteria
LB319_08655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LB319_08660	COG0019	diaminopimelate decarboxylase activity
LB319_08670	COG0165	Argininosuccinate lyase
LB319_08675	COG1979	alcohol dehydrogenase
LB319_08680	COG3321	synthase
LB319_08680	COG0604	alcohol dehydrogenase
LB319_08685	COG0656	L-ascorbic acid biosynthetic process
LB319_08725	COG0668	transmembrane transport
LB319_08760	COG1132	(ABC) transporter
LB319_08765	COG0129	dihydroxy-acid dehydratase activity
LB319_08770	COG0583	DNA-binding transcription factor activity
LB319_08785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LB319_08790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LB319_08795	COG0539	negative regulation of cytoplasmic translation
LB319_08805	COG0776	regulation of translation
LB319_08815	COG0531	amino acid
LB319_08820	COG0546	phosphoglycolate phosphatase activity
LB319_08825	COG0110	maltose O-acetyltransferase activity
LB319_08850	COG4658	electron transport chain
LB319_08855	COG4656	Part of a membrane complex involved in electron transport
LB319_08865	COG4657	Part of a membrane complex involved in electron transport
LB319_08875	COG3604	Transcriptional regulator
LB319_08880	COG0535	radical SAM domain protein
LB319_08885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LB319_08895	COG5554	nitrogen fixation
LB319_08905	COG4774	siderophore transport
LB319_08910	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LB319_08915	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LB319_08920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LB319_08925	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LB319_08930	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LB319_08935	COG1433	Dinitrogenase iron-molybdenum cofactor
LB319_08965	COG1104	cysteine desulfurase activity
LB319_08970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LB319_08985	COG3585	molybdate ion transport
LB319_09005	COG0673	inositol 2-dehydrogenase activity
LB319_09010	COG2824	Alkylphosphonate utilization operon protein PhnA
LB319_09015	COG1120	ATPase activity
LB319_09020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LB319_09040	COG0716	FMN binding
LB319_09045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LB319_09065	COG0583	DNA-binding transcription factor activity
LB319_09130	COG3654	unkown
LB319_09160	COG1132	(ABC) transporter
LB319_09165	COG1132	(ABC) transporter
LB319_09165	COG2375	cellular response to nickel ion
LB319_09190	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_09200	COG3041	Addiction module toxin RelE StbE family
LB319_09285	COG3750	Belongs to the UPF0335 family
LB319_09310	COG1192	Involved in chromosome partitioning
LB319_09320	COG4695	Portal protein
LB319_09480	COG3041	Addiction module toxin RelE StbE family
LB319_09485	COG3077	Addiction module antitoxin, RelB DinJ family
LB319_09490	COG3645	SOS response
LB319_09505	COG1301	dicarboxylic acid transport
LB319_09515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LB319_09535	COG1028	Short-chain dehydrogenase reductase Sdr
LB319_09555	COG2814	Major facilitator Superfamily
LB319_09560	COG1064	alcohol dehydrogenase
LB319_09570	COG0667	Aldo Keto reductase
LB319_09575	COG0667	Aldo Keto reductase
LB319_09585	COG3293	Transposase
LB319_09660	COG3654	unkown
LB319_09680	COG1192	Involved in chromosome partitioning
LB319_09715	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LB319_09720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LB319_09725	COG0732	type I restriction modification DNA specificity domain
LB319_09740	COG1715	Restriction endonuclease
LB319_09745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LB319_09760	COG1192	Involved in chromosome partitioning
LB319_09785	COG3311	Transcriptional regulator
LB319_09825	COG2337	Toxic component of a toxin-antitoxin (TA) module