locus-tag	class	description
ZZ6_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZZ6_0002	COG0488	(ABC) transporter
ZZ6_0003	COG2885	chlorophyll binding
ZZ6_0003	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZZ6_0004	COG4702	Belongs to the UPF0303 family
ZZ6_0005	COG0670	Belongs to the BI1 family
ZZ6_0007	COG1058	Belongs to the CinA family
ZZ6_0007	COG1546	Belongs to the CinA family
ZZ6_0008	COG0024	Methionine aminopeptidase
ZZ6_0011	COG0308	aminopeptidase N
ZZ6_0014	COG2321	neutral zinc metallopeptidase
ZZ6_0016	COG1280	lysine exporter protein (LysE YggA)
ZZ6_0017	COG1741	Belongs to the pirin family
ZZ6_0018	COG0583	DNA-binding transcription factor activity
ZZ6_0019	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZZ6_0020	COG2353	YceI-like domain
ZZ6_0021	COG0668	transmembrane transport
ZZ6_0022	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZZ6_0023	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZZ6_0024	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZZ6_0026	COG1660	Displays ATPase and GTPase activities
ZZ6_0027	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZZ6_0028	COG0642	Histidine kinase
ZZ6_0029	COG0745	RESPONSE REGULATOR receiver
ZZ6_0033	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZZ6_0034	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZZ6_0035	COG2244	polysaccharide biosynthetic process
ZZ6_0037	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZZ6_0038	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZZ6_0039	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZZ6_0040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ZZ6_0041	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZZ6_0043	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ZZ6_0043	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ZZ6_0044	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZZ6_0047	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZZ6_0048	COG0321	lipoyl(octanoyl) transferase activity
ZZ6_0056	COG0602	queuosine metabolic process
ZZ6_0057	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZZ6_0060	COG2261	transglycosylase associated protein
ZZ6_0061	COG2223	nitrite transmembrane transporter activity
ZZ6_0066	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZZ6_0067	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZZ6_0068	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZZ6_0070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZZ6_0072	COG1012	belongs to the aldehyde dehydrogenase family
ZZ6_0074	COG0156	8-amino-7-oxononanoate synthase activity
ZZ6_0078	COG0519	Catalyzes the synthesis of GMP from XMP
ZZ6_0078	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZZ6_0079	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZZ6_0081	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ZZ6_0082	COG1138	Cytochrome C-type biogenesis protein
ZZ6_0083	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZZ6_0084	COG3088	subunit of a heme lyase
ZZ6_0089	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZZ6_0091	COG2866	Carboxypeptidase
ZZ6_0092	COG0588	phosphoglycerate mutase activity
ZZ6_0094	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZZ6_0096	COG1064	alcohol dehydrogenase
ZZ6_0098	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZZ6_0105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZZ6_0105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZZ6_0106	COG0302	gtp cyclohydrolase
ZZ6_0107	COG4948	Mandelate Racemase Muconate Lactonizing
ZZ6_0108	COG0359	binds to the 23S rRNA
ZZ6_0109	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZZ6_0110	COG0360	Binds together with S18 to 16S ribosomal RNA
ZZ6_0111	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZZ6_0114	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZZ6_0115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZZ6_0116	COG0805	protein transport
ZZ6_0121	COG0513	Belongs to the DEAD box helicase family
ZZ6_0123	COG0166	Belongs to the GPI family
ZZ6_0125	COG3158	transport of potassium into the cell
ZZ6_0126	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZZ6_0131	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZZ6_0132	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZZ6_0134	COG0156	8-amino-7-oxononanoate synthase activity
ZZ6_0135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZZ6_0137	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ZZ6_0138	COG0758	DNA mediated transformation
ZZ6_0139	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZZ6_0139	COG1754	DNA topoisomerase type I activity
ZZ6_0140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZZ6_0141	COG0756	dUTP diphosphatase activity
ZZ6_0142	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZZ6_0143	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZZ6_0144	COG2226	methyltransferase
ZZ6_0145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZZ6_0150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZZ6_0153	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZZ6_0154	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZZ6_0156	COG2205	protein histidine kinase activity
ZZ6_0159	COG3724	N-succinylarginine dihydrolase activity
ZZ6_0160	COG1472	Belongs to the glycosyl hydrolase 3 family
ZZ6_0162	COG2971	BadF BadG BcrA BcrD
ZZ6_0164	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZZ6_0165	COG1040	competence protein
ZZ6_0166	COG0745	RESPONSE REGULATOR receiver
ZZ6_0167	COG0704	Plays a role in the regulation of phosphate uptake
ZZ6_0169	COG0688	phosphatidylethanolamine metabolic process
ZZ6_0170	COG1183	phosphatidylcholine synthase activity
ZZ6_0172	COG0052	Belongs to the universal ribosomal protein uS2 family
ZZ6_0173	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZZ6_0174	COG0528	UMP kinase activity
ZZ6_0175	COG0233	cytoplasmic translational termination
ZZ6_0176	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZZ6_0177	COG0575	Belongs to the CDS family
ZZ6_0178	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZZ6_0179	COG0750	zinc metalloprotease
ZZ6_0180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZZ6_0182	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZZ6_0183	COG0254	rRNA binding
ZZ6_0186	COG0492	ferredoxin-NADP+ reductase activity
ZZ6_0187	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZZ6_0188	COG0440	acetolactate synthase activity
ZZ6_0189	COG0028	Belongs to the TPP enzyme family
ZZ6_0190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZZ6_0192	COG1858	cytochrome C peroxidase
ZZ6_0193	COG0312	modulator of DNA gyrase
ZZ6_0195	COG0288	reversible hydration of carbon dioxide
ZZ6_0196	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZZ6_0197	COG2867	negative regulation of translational initiation
ZZ6_0198	COG1058	Belongs to the CinA family
ZZ6_0198	COG1546	Belongs to the CinA family
ZZ6_0200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZZ6_0200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZZ6_0202	COG2204	response regulator
ZZ6_0203	COG5000	phosphorelay sensor kinase activity
ZZ6_0204	COG2204	response regulator
ZZ6_0206	COG0776	regulation of translation
ZZ6_0211	COG1968	undecaprenyl-diphosphatase activity
ZZ6_0213	COG1252	NADH dehydrogenase
ZZ6_0214	COG2917	probably involved in intracellular septation
ZZ6_0215	COG2807	transmembrane transport
ZZ6_0217	COG1522	sequence-specific DNA binding
ZZ6_0219	COG2205	protein histidine kinase activity
ZZ6_0220	COG0802	atpase or kinase
ZZ6_0221	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ZZ6_0223	COG1074	ATP-dependent DNA helicase activity
ZZ6_0225	COG0557	exoribonuclease II activity
ZZ6_0226	COG3956	TIGRFAM MazG family protein
ZZ6_0228	COG0084	hydrolase, TatD family'
ZZ6_0230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZZ6_0231	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZZ6_0232	COG1686	Belongs to the peptidase S11 family
ZZ6_0234	COG2951	lytic endotransglycosylase activity
ZZ6_0235	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ZZ6_0236	COG0457	Tetratricopeptide repeat
ZZ6_0237	COG1215	transferase activity, transferring glycosyl groups
ZZ6_0238	COG1215	transferase activity, transferring glycosyl groups
ZZ6_0241	COG0335	large ribosomal subunit rRNA binding
ZZ6_0242	COG0336	Belongs to the RNA methyltransferase TrmD family
ZZ6_0243	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZZ6_0244	COG0228	four-way junction DNA binding
ZZ6_0245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZZ6_0246	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZZ6_0247	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZZ6_0248	COG0552	protein localization to endoplasmic reticulum
ZZ6_0249	COG0484	heat shock protein binding
ZZ6_0255	COG1842	Phage shock protein A
ZZ6_0257	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZZ6_0258	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZZ6_0261	COG0617	tRNA 3'-terminal CCA addition
ZZ6_0263	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZZ6_0264	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZZ6_0265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZZ6_0266	COG0581	inorganic phosphate transmembrane transporter activity
ZZ6_0267	COG0573	inorganic phosphate transmembrane transporter activity
ZZ6_0268	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZZ6_0270	COG1970	mechanosensitive ion channel activity
ZZ6_0272	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ZZ6_0277	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZZ6_0278	COG0137	argininosuccinate synthase activity
ZZ6_0280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ZZ6_0281	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZZ6_0287	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZZ6_0288	COG1104	cysteine desulfurase activity
ZZ6_0289	COG2945	thiolester hydrolase activity
ZZ6_0290	COG0019	diaminopimelate decarboxylase activity
ZZ6_0292	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZZ6_0293	COG1127	ABC transporter
ZZ6_0296	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZZ6_0297	COG0424	maF-like protein
ZZ6_0299	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ZZ6_0302	COG0277	FAD linked oxidase domain protein
ZZ6_0303	COG3781	membrane
ZZ6_0304	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZZ6_0306	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZZ6_0307	COG0351	phosphomethylpyrimidine kinase
ZZ6_0307	COG0352	thiamine-phosphate diphosphorylase activity
ZZ6_0308	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZZ6_0309	COG3104	oligopeptide transport
ZZ6_0310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZZ6_0311	COG0009	L-threonylcarbamoyladenylate synthase
ZZ6_0312	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZZ6_0313	COG0800	Aldolase
ZZ6_0317	COG0071	Belongs to the small heat shock protein (HSP20) family
ZZ6_0320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZZ6_0321	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZZ6_0322	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZZ6_0326	COG4172	Belongs to the ABC transporter superfamily
ZZ6_0327	COG0592	DNA-directed DNA polymerase activity
ZZ6_0328	COG4206	TonB-dependent receptor
ZZ6_0330	COG0667	Aldo Keto reductase
ZZ6_0332	COG3394	polysaccharide catabolic process
ZZ6_0335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZZ6_0337	COG2252	PERMEase
ZZ6_0339	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZZ6_0340	COG2814	Major facilitator Superfamily
ZZ6_0341	COG1566	PFAM secretion protein HlyD family protein
ZZ6_0344	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ZZ6_0346	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZZ6_0347	COG2857	Cytochrome c1
ZZ6_0348	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZZ6_0349	COG0723	plastoquinol--plastocyanin reductase activity
ZZ6_0351	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZZ6_0352	COG0408	coproporphyrinogen oxidase activity
ZZ6_0354	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZZ6_0355	COG0740	serine-type endopeptidase activity
ZZ6_0357	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZZ6_0359	COG1621	beta-fructofuranosidase activity
ZZ6_0361	COG1846	Transcriptional regulator
ZZ6_0362	COG0402	S-adenosylhomocysteine deaminase activity
ZZ6_0363	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ZZ6_0364	COG1448	Aminotransferase
ZZ6_0365	COG0697	spore germination
ZZ6_0371	COG3191	aminopeptidase activity
ZZ6_0372	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZZ6_0375	COG1278	Cold shock
ZZ6_0376	COG0653	protein targeting
ZZ6_0377	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZZ6_0381	COG3706	GGDEF domain
ZZ6_0381	COG0745	RESPONSE REGULATOR receiver
ZZ6_0386	COG2217	Heavy metal translocating P-type atpase
ZZ6_0387	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZZ6_0388	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZZ6_0394	COG2943	transferase activity, transferring hexosyl groups
ZZ6_0395	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZZ6_0397	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZZ6_0400	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZZ6_0400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZZ6_0406	COG1199	ATP-dependent helicase activity
ZZ6_0406	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZZ6_0408	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZZ6_0413	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZZ6_0414	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZZ6_0416	COG2198	Histidine kinase
ZZ6_0416	COG0643	Histidine kinase
ZZ6_0417	COG2201	protein-glutamate methylesterase activity
ZZ6_0420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZZ6_0423	COG1657	PFAM Prenyltransferase squalene oxidase
ZZ6_0424	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ZZ6_0425	COG1562	ergosterol biosynthetic process
ZZ6_0426	COG1562	ergosterol biosynthetic process
ZZ6_0427	COG1215	transferase activity, transferring glycosyl groups
ZZ6_0428	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZZ6_0430	COG0305	Participates in initiation and elongation during chromosome replication
ZZ6_0431	COG0295	cytidine deaminase activity
ZZ6_0432	COG0717	Belongs to the dCTP deaminase family
ZZ6_0433	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZZ6_0434	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZZ6_0436	COG1104	cysteine desulfurase activity
ZZ6_0438	COG1722	exodeoxyribonuclease VII activity
ZZ6_0439	COG0142	geranyltranstransferase activity
ZZ6_0440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZZ6_0441	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZZ6_0442	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZZ6_0443	COG0259	pyridoxamine-phosphate oxidase activity
ZZ6_0449	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZZ6_0451	COG0018	arginyl-trna synthetase
ZZ6_0452	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZZ6_0453	COG0038	chloride channel
ZZ6_0455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZZ6_0456	COG0849	cell division
ZZ6_0457	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZZ6_0458	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZZ6_0459	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZZ6_0460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZZ6_0461	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZZ6_0463	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZZ6_0464	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZZ6_0466	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZZ6_0469	COG0275	rRNA processing
ZZ6_0473	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZZ6_0474	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZZ6_0475	COG0720	synthase
ZZ6_0478	COG1322	Protein conserved in bacteria
ZZ6_0479	COG0242	peptide deformylase activity
ZZ6_0480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZZ6_0481	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZZ6_0482	COG0101	tRNA pseudouridine synthase activity
ZZ6_0483	COG1872	DUF167
ZZ6_0484	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZZ6_0485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZZ6_0487	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ZZ6_0490	COG1129	ABC transporter
ZZ6_0490	COG0842	Transport permease protein
ZZ6_0491	COG0842	Transport permease protein
ZZ6_0493	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_0496	COG1505	serine-type exopeptidase activity
ZZ6_0498	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZZ6_0499	COG0540	Belongs to the ATCase OTCase family
ZZ6_0508	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZZ6_0509	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZZ6_0510	COG0154	amidase activity
ZZ6_0511	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZZ6_0512	COG0583	DNA-binding transcription factor activity
ZZ6_0513	COG1538	Outer membrane efflux protein
ZZ6_0516	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZZ6_0519	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZZ6_0520	COG2239	Acts as a magnesium transporter
ZZ6_0521	COG0482	sulfurtransferase activity
ZZ6_0524	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ZZ6_0525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZZ6_0529	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZZ6_0534	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ZZ6_0537	COG0564	pseudouridine synthase activity
ZZ6_0538	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZZ6_0544	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZZ6_0546	COG2329	Antibiotic biosynthesis monooxygenase
ZZ6_0547	COG2022	thiamine diphosphate biosynthetic process
ZZ6_0548	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZZ6_0549	COG0511	ligase activity, forming carbon-carbon bonds
ZZ6_0550	COG0439	Biotin carboxylase
ZZ6_0552	COG0456	acetyltransferase
ZZ6_0553	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZZ6_0554	COG0085	RNA polymerase activity
ZZ6_0555	COG0222	ribosome binding
ZZ6_0556	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZZ6_0557	COG0081	regulation of translation
ZZ6_0558	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZZ6_0561	COG3590	peptidase
ZZ6_0562	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZZ6_0563	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZZ6_0564	COG0741	lytic transglycosylase activity
ZZ6_0566	COG2326	polyphosphate kinase activity
ZZ6_0567	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZZ6_0568	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ZZ6_0569	COG0248	Ppx GppA phosphatase
ZZ6_0570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZZ6_0573	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZZ6_0574	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZZ6_0575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZZ6_0582	COG2076	Multidrug Resistance protein
ZZ6_0587	COG1764	response to oxidative stress
ZZ6_0588	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZZ6_0589	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZZ6_0591	COG0673	inositol 2-dehydrogenase activity
ZZ6_0602	COG0473	3-isopropylmalate dehydrogenase activity
ZZ6_0604	COG0583	DNA-binding transcription factor activity
ZZ6_0606	COG1381	Involved in DNA repair and RecF pathway recombination
ZZ6_0607	COG0322	excinuclease ABC activity
ZZ6_0608	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZZ6_0609	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZZ6_0611	COG0356	it plays a direct role in the translocation of protons across the membrane
ZZ6_0616	COG2003	Belongs to the UPF0758 family
ZZ6_0617	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZZ6_0618	COG0484	heat shock protein binding
ZZ6_0619	COG0443	Heat shock 70 kDa protein
ZZ6_0622	COG3138	arginine N-succinyltransferase
ZZ6_0625	COG0726	polysaccharide deacetylase
ZZ6_0626	COG0628	permease
ZZ6_0629	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZZ6_0631	COG1987	bacterial-type flagellum assembly
ZZ6_0635	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZZ6_0641	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZZ6_0643	COG1677	Flagellar hook-basal body complex protein FliE
ZZ6_0649	COG0455	bacterial-type flagellum organization
ZZ6_0656	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZZ6_0658	COG1558	bacterial-type flagellum-dependent cell motility
ZZ6_0659	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZZ6_0660	COG1749	Flagellar hook protein flgE
ZZ6_0662	COG4786	Flagellar basal body rod
ZZ6_0663	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ZZ6_0664	COG1706	bacterial-type flagellum-dependent cell motility
ZZ6_0667	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZZ6_0669	COG1360	Flagellar Motor Protein
ZZ6_0672	COG0825	malonyl-CoA metabolic process
ZZ6_0673	COG4974	Belongs to the 'phage' integrase family
ZZ6_0676	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZZ6_0677	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZZ6_0680	COG1286	toxin biosynthetic process
ZZ6_0683	COG0284	orotidine-5'-phosphate decarboxylase activity
ZZ6_0684	COG0135	phosphoribosylanthranilate isomerase activity
ZZ6_0685	COG0133	tryptophan synthase activity
ZZ6_0686	COG0159	tryptophan synthase activity
ZZ6_0687	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZZ6_0688	COG0285	dihydrofolate synthase activity
ZZ6_0689	COG2223	nitrite transmembrane transporter activity
ZZ6_0690	COG1301	dicarboxylic acid transport
ZZ6_0691	COG1187	pseudouridine synthase activity
ZZ6_0692	COG0742	ribosomal rna small subunit methyltransferase
ZZ6_0694	COG2999	glutathione oxidoreductase activity
ZZ6_0695	COG1116	anion transmembrane transporter activity
ZZ6_0696	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZZ6_0697	COG2264	protein methyltransferase activity
ZZ6_0701	COG2814	Major facilitator Superfamily
ZZ6_0702	COG1643	Atp-dependent helicase
ZZ6_0703	COG0142	geranyltranstransferase activity
ZZ6_0704	COG1605	Chorismate mutase
ZZ6_0704	COG0287	Prephenate dehydrogenase
ZZ6_0705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZZ6_0707	COG2133	pyrroloquinoline quinone binding
ZZ6_0708	COG0779	Required for maturation of 30S ribosomal subunits
ZZ6_0711	COG3064	Membrane
ZZ6_0711	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZZ6_0712	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZZ6_0713	COG1435	thymidine kinase activity
ZZ6_0714	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZZ6_0715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZZ6_0716	COG1185	polyribonucleotide nucleotidyltransferase activity
ZZ6_0718	COG0038	chloride channel
ZZ6_0719	COG0659	secondary active sulfate transmembrane transporter activity
ZZ6_0720	COG0134	indole-3-glycerol-phosphate synthase activity
ZZ6_0721	COG0538	isocitrate dehydrogenase activity
ZZ6_0722	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZZ6_0723	COG0203	ribosomal protein L17
ZZ6_0724	COG0202	RNA polymerase activity
ZZ6_0725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZZ6_0726	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZZ6_0727	COG0563	adenylate kinase activity
ZZ6_0728	COG0201	protein transport
ZZ6_0729	COG0200	Binds to the 23S rRNA
ZZ6_0730	COG1841	ribosomal large subunit assembly
ZZ6_0731	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZZ6_0732	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZZ6_0733	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZZ6_0734	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZZ6_0735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZZ6_0736	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZZ6_0737	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZZ6_0738	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZZ6_0739	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZZ6_0740	COG0255	Belongs to the universal ribosomal protein uL29 family
ZZ6_0741	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZZ6_0742	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZZ6_0743	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZZ6_0744	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZZ6_0745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZZ6_0746	COG0089	rRNA binding
ZZ6_0747	COG0088	Forms part of the polypeptide exit tunnel
ZZ6_0748	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZZ6_0749	COG0051	transcription antitermination factor activity, RNA binding
ZZ6_0750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZZ6_0751	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZZ6_0752	COG0049	tRNA binding
ZZ6_0753	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZZ6_0754	COG0671	phosphoesterase, PA-phosphatase related
ZZ6_0755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZZ6_0756	COG1607	acyl-coa hydrolase
ZZ6_0757	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZZ6_0760	COG1956	GAF domain-containing protein
ZZ6_0762	COG0564	pseudouridine synthase activity
ZZ6_0763	COG0463	Glycosyl transferase, family 2
ZZ6_0767	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZZ6_0768	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZZ6_0769	COG0546	phosphoglycolate phosphatase activity
ZZ6_0773	COG0174	glutamine synthetase
ZZ6_0774	COG0347	Belongs to the P(II) protein family
ZZ6_0775	COG0006	proline dipeptidase activity
ZZ6_0779	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ZZ6_0780	COG1960	acyl-CoA dehydrogenase activity
ZZ6_0783	COG1494	fructose-1,6-bisphosphatase
ZZ6_0785	COG5002	protein histidine kinase activity
ZZ6_0789	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZZ6_0789	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZZ6_0792	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZZ6_0794	COG0583	DNA-binding transcription factor activity
ZZ6_0796	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZZ6_0798	COG0149	triose-phosphate isomerase activity
ZZ6_0800	COG0504	CTP synthase activity
ZZ6_0801	COG0442	prolyl-tRNA aminoacylation
ZZ6_0803	COG1136	(ABC) transporter
ZZ6_0804	COG1522	sequence-specific DNA binding
ZZ6_0806	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ZZ6_0807	COG1160	GTP binding
ZZ6_0812	COG1696	Membrane protein involved in D-alanine export
ZZ6_0815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZZ6_0815	COG1372	Participates in initiation and elongation during chromosome replication
ZZ6_0816	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZZ6_0824	COG0194	GDP metabolic process
ZZ6_0825	COG2171	N-acyltransferase activity
ZZ6_0827	COG0316	Belongs to the HesB IscA family
ZZ6_0828	COG2151	metal-sulfur cluster biosynthetic enzyme
ZZ6_0829	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZZ6_0830	COG0719	Fe-S assembly protein
ZZ6_0831	COG0396	ATPase activity
ZZ6_0832	COG0719	Fe-S assembly protein
ZZ6_0834	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZZ6_0835	COG0287	Prephenate dehydrogenase
ZZ6_0839	COG2884	Cell division ATP-binding protein ftsE
ZZ6_0842	COG2095	MarC family integral membrane protein
ZZ6_0843	COG0187	DNA topoisomerase II activity
ZZ6_0844	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ZZ6_0845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZZ6_0846	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZZ6_0848	COG0842	Transport permease protein
ZZ6_0850	COG0248	Ppx GppA phosphatase
ZZ6_0851	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ZZ6_0852	COG5001	Diguanylate cyclase
ZZ6_0874	COG1621	beta-fructofuranosidase activity
ZZ6_0875	COG1621	beta-fructofuranosidase activity
ZZ6_0877	COG1522	sequence-specific DNA binding
ZZ6_0878	COG1794	racemase activity, acting on amino acids and derivatives
ZZ6_0879	COG0837	glucose binding
ZZ6_0880	COG0129	dihydroxy-acid dehydratase activity
ZZ6_0881	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZZ6_0882	COG0477	Major facilitator Superfamily
ZZ6_0883	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZZ6_0884	COG0343	queuine tRNA-ribosyltransferase activity
ZZ6_0885	COG0556	nucleotide-excision repair
ZZ6_0887	COG0772	Belongs to the SEDS family
ZZ6_0890	COG1792	Involved in formation and maintenance of cell shape
ZZ6_0892	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZZ6_0897	COG1678	Uncharacterized ACR, COG1678
ZZ6_0898	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZZ6_0899	COG1923	regulation of RNA biosynthetic process
ZZ6_0900	COG0004	ammonium transporteR
ZZ6_0902	COG0312	modulator of DNA gyrase
ZZ6_0908	COG1192	Involved in chromosome partitioning
ZZ6_0909	COG0352	thiamine-phosphate diphosphorylase activity
ZZ6_0910	COG3108	Peptidase M15
ZZ6_0911	COG0483	inositol monophosphate 1-phosphatase activity
ZZ6_0912	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZZ6_0913	COG0626	cystathionine gamma-synthase activity
ZZ6_0914	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZZ6_0916	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZZ6_0917	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZZ6_0918	COG0196	riboflavin kinase activity
ZZ6_0921	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_0923	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZZ6_0927	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_0931	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZZ6_0934	COG1570	exodeoxyribonuclease VII activity
ZZ6_0935	COG0151	Belongs to the GarS family
ZZ6_0937	COG1253	flavin adenine dinucleotide binding
ZZ6_0938	COG0590	tRNA wobble adenosine to inosine editing
ZZ6_0939	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZZ6_0940	COG2814	Major facilitator Superfamily
ZZ6_0941	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZZ6_0942	COG2733	membrane
ZZ6_0945	COG1538	Outer membrane efflux protein
ZZ6_0947	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZZ6_0949	COG1278	Cold shock
ZZ6_0953	COG1137	ATPase activity
ZZ6_0954	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZZ6_0956	COG0277	FAD linked oxidase domain protein
ZZ6_0957	COG0745	RESPONSE REGULATOR receiver
ZZ6_0958	COG2205	protein histidine kinase activity
ZZ6_0959	COG4133	protoheme IX ABC transporter activity
ZZ6_0960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZZ6_0964	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZZ6_0965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZZ6_0969	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZZ6_0970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZZ6_0971	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZZ6_0972	COG0776	regulation of translation
ZZ6_0974	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZZ6_0975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZZ6_0976	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZZ6_0977	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZZ6_0978	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZZ6_0979	COG0489	protein tyrosine kinase activity
ZZ6_0980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZZ6_0982	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZZ6_0984	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZZ6_0985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZZ6_0987	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZZ6_0987	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZZ6_0988	COG4221	oxidoreductase activity
ZZ6_0989	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZZ6_0990	COG2813	Specifically methylates the guanine in position
ZZ6_0990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZZ6_0993	COG1329	Transcriptional regulator
ZZ6_0994	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ZZ6_0995	COG4581	dead DEAH box helicase
ZZ6_0996	COG0739	heme binding
ZZ6_0998	COG0534	Mate efflux family protein
ZZ6_1000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZZ6_1001	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZZ6_1003	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZZ6_1004	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZZ6_1007	COG0789	Transcriptional regulator
ZZ6_1012	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZZ6_1013	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZZ6_1015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZZ6_1019	COG1530	ribonuclease E activity
ZZ6_1023	COG1760	l-serine dehydratase
ZZ6_1025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ZZ6_1026	COG0215	cysteine-tRNA ligase activity
ZZ6_1028	COG0488	(ABC) transporter
ZZ6_1029	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZZ6_1030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZZ6_1031	COG1830	Aldolase
ZZ6_1032	COG2194	sulfuric ester hydrolase activity
ZZ6_1033	COG0126	phosphoglycerate kinase activity
ZZ6_1034	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZZ6_1039	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZZ6_1041	COG0584	glycerophosphoryl diester phosphodiesterase
ZZ6_1042	COG2885	chlorophyll binding
ZZ6_1043	COG0823	Involved in the tonB-independent uptake of proteins
ZZ6_1045	COG0848	biopolymer transport protein
ZZ6_1046	COG0811	peptide transport
ZZ6_1047	COG0824	Thioesterase
ZZ6_1048	COG2255	four-way junction helicase activity
ZZ6_1049	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZZ6_1051	COG0632	four-way junction helicase activity
ZZ6_1052	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZZ6_1053	COG0217	transcriptional regulatory protein
ZZ6_1054	COG3750	Belongs to the UPF0335 family
ZZ6_1055	COG0469	pyruvate kinase activity
ZZ6_1058	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZZ6_1062	COG1131	(ABC) transporter
ZZ6_1064	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZZ6_1075	COG0671	phosphoesterase, PA-phosphatase related
ZZ6_1078	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZZ6_1082	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZZ6_1085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZZ6_1086	COG1151	hydroxylamine reductase activity
ZZ6_1087	COG1959	2 iron, 2 sulfur cluster binding
ZZ6_1088	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZZ6_1089	COG0512	Glutamine amidotransferase of anthranilate synthase
ZZ6_1089	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZZ6_1090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZZ6_1094	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ZZ6_1097	COG0463	Glycosyl transferase, family 2
ZZ6_1100	COG0066	3-isopropylmalate dehydratase activity
ZZ6_1101	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZZ6_1102	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZZ6_1109	COG2999	glutathione oxidoreductase activity
ZZ6_1112	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZZ6_1113	COG1702	phosphate starvation-inducible protein PhoH
ZZ6_1114	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZZ6_1115	COG0835	chemotaxis
ZZ6_1117	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ZZ6_1118	COG2201	protein-glutamate methylesterase activity
ZZ6_1119	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZZ6_1120	COG2198	Histidine kinase
ZZ6_1120	COG0643	Histidine kinase
ZZ6_1122	COG0840	transmembrane signaling receptor activity
ZZ6_1127	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_1129	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZZ6_1131	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZZ6_1144	COG1929	Belongs to the glycerate kinase type-1 family
ZZ6_1146	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZZ6_1147	COG0730	response to heat
ZZ6_1148	COG1846	Transcriptional regulator
ZZ6_1150	COG2807	transmembrane transport
ZZ6_1153	COG0424	maF-like protein
ZZ6_1155	COG0237	dephospho-CoA kinase activity
ZZ6_1156	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZZ6_1157	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ZZ6_1158	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZZ6_1161	COG2983	Belongs to the UPF0260 family
ZZ6_1164	COG1715	Restriction endonuclease
ZZ6_1165	COG0138	bifunctional purine biosynthesis protein purh
ZZ6_1167	COG0247	lactate metabolic process
ZZ6_1168	COG1139	Iron-sulfur cluster binding protein
ZZ6_1171	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZZ6_1173	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZZ6_1174	COG1420	regulation of RNA biosynthetic process
ZZ6_1175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZZ6_1176	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZZ6_1177	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZZ6_1180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZZ6_1181	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZZ6_1182	COG0175	sulfate reduction
ZZ6_1183	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZZ6_1183	COG1648	precorrin-2 dehydrogenase activity
ZZ6_1184	COG0175	sulfate reduction
ZZ6_1191	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZZ6_1193	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ZZ6_1195	COG0412	Dienelactone hydrolase
ZZ6_1196	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZZ6_1197	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZZ6_1200	COG0445	tRNA wobble uridine modification
ZZ6_1201	COG0357	Ribosomal RNA small subunit methyltransferase G
ZZ6_1202	COG1192	Involved in chromosome partitioning
ZZ6_1203	COG1475	DNA binding
ZZ6_1204	COG0477	Major facilitator Superfamily
ZZ6_1210	COG2333	competence protein COMEC
ZZ6_1210	COG0658	competence protein
ZZ6_1211	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZZ6_1212	COG0372	Belongs to the citrate synthase family
ZZ6_1213	COG5002	protein histidine kinase activity
ZZ6_1218	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZZ6_1218	COG0438	transferase activity, transferring glycosyl groups
ZZ6_1219	COG0497	DNA recombination
ZZ6_1220	COG0281	malic enzyme
ZZ6_1221	COG0459	protein refolding
ZZ6_1222	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZZ6_1223	COG0616	signal peptide processing
ZZ6_1226	COG1368	sulfuric ester hydrolase activity
ZZ6_1232	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZZ6_1233	COG0156	8-amino-7-oxononanoate synthase activity
ZZ6_1235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZZ6_1235	COG4106	trans-aconitate 2-methyltransferase activity
ZZ6_1237	COG0189	ligase activity
ZZ6_1238	COG0012	GTP binding
ZZ6_1239	COG0193	aminoacyl-tRNA hydrolase activity
ZZ6_1240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZZ6_1243	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZZ6_1244	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZZ6_1245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZZ6_1246	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZZ6_1247	COG0181	hydroxymethylbilane synthase activity
ZZ6_1250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ZZ6_1251	COG0416	fatty acid biosynthetic process
ZZ6_1252	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZZ6_1254	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZZ6_1256	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZZ6_1259	COG0612	Peptidase, M16
ZZ6_1261	COG1335	isochorismatase
ZZ6_1262	COG3180	Ammonia monooxygenase
ZZ6_1263	COG1902	pentaerythritol trinitrate reductase activity
ZZ6_1264	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZZ6_1265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZZ6_1266	COG3180	Ammonia monooxygenase
ZZ6_1268	COG0113	porphobilinogen synthase activity
ZZ6_1269	COG0525	valine-tRNA ligase activity
ZZ6_1274	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ZZ6_1280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZZ6_1293	COG0716	FMN binding
ZZ6_1298	COG1120	ATPase activity
ZZ6_1299	COG2824	Alkylphosphonate utilization operon protein PhnA
ZZ6_1300	COG0673	inositol 2-dehydrogenase activity
ZZ6_1304	COG3585	molybdate ion transport
ZZ6_1305	COG0157	Belongs to the NadC ModD family
ZZ6_1307	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZZ6_1311	COG4774	siderophore transport
ZZ6_1313	COG5554	nitrogen fixation
ZZ6_1315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZZ6_1316	COG0535	radical SAM domain protein
ZZ6_1318	COG4657	Part of a membrane complex involved in electron transport
ZZ6_1319	COG2878	Part of a membrane complex involved in electron transport
ZZ6_1321	COG4658	electron transport chain
ZZ6_1325	COG0546	phosphoglycolate phosphatase activity
ZZ6_1326	COG0531	amino acid
ZZ6_1328	COG0776	regulation of translation
ZZ6_1330	COG0539	negative regulation of cytoplasmic translation
ZZ6_1331	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZZ6_1332	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZZ6_1335	COG0583	DNA-binding transcription factor activity
ZZ6_1336	COG0129	dihydroxy-acid dehydratase activity
ZZ6_1338	COG1132	(ABC) transporter
ZZ6_1351	COG0656	L-ascorbic acid biosynthetic process
ZZ6_1352	COG1063	alcohol dehydrogenase
ZZ6_1353	COG1979	alcohol dehydrogenase
ZZ6_1354	COG0165	Argininosuccinate lyase
ZZ6_1356	COG0019	diaminopimelate decarboxylase activity
ZZ6_1357	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZZ6_1359	COG2989	Protein conserved in bacteria
ZZ6_1361	COG0792	nuclease activity
ZZ6_1362	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZZ6_1365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZZ6_1366	COG3265	gluconokinase activity
ZZ6_1367	COG2610	gluconate transmembrane transporter activity
ZZ6_1368	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZZ6_1369	COG1012	belongs to the aldehyde dehydrogenase family
ZZ6_1374	COG2853	Lipoprotein
ZZ6_1378	COG0646	methionine synthase
ZZ6_1378	COG1410	methionine synthase
ZZ6_1380	COG0481	GTPase activity
ZZ6_1382	COG3275	phosphorelay sensor kinase activity
ZZ6_1383	COG3279	Response regulator of the LytR AlgR family
ZZ6_1386	COG0583	DNA-binding transcription factor activity
ZZ6_1388	COG1045	serine acetyltransferase
ZZ6_1391	COG0436	Aminotransferase
ZZ6_1392	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ZZ6_1393	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZZ6_1396	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ZZ6_1398	COG1758	RNA polymerase activity
ZZ6_1399	COG1940	carbohydrate kinase activity
ZZ6_1405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZZ6_1407	COG0628	permease
ZZ6_1408	COG0681	Belongs to the peptidase S26 family
ZZ6_1409	COG0736	holo-[acyl-carrier-protein] synthase activity
ZZ6_1410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZZ6_1411	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZZ6_1414	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZZ6_1415	COG1674	ftsk spoiiie
ZZ6_1416	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ZZ6_1418	COG0708	Exodeoxyribonuclease III
ZZ6_1420	COG1733	regulation of RNA biosynthetic process
ZZ6_1421	COG1064	alcohol dehydrogenase
ZZ6_1424	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZZ6_1425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZZ6_1426	COG1295	ribonuclease BN
ZZ6_1427	COG0484	heat shock protein binding
ZZ6_1428	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZZ6_1430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZZ6_1432	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZZ6_1434	COG0252	asparaginase activity
ZZ6_1436	COG2985	domain, Protein
ZZ6_1439	COG0077	Prephenate dehydratase
ZZ6_1440	COG1194	a g-specific adenine glycosylase
ZZ6_1443	COG0656	L-ascorbic acid biosynthetic process
ZZ6_1449	COG0793	Belongs to the peptidase S41A family
ZZ6_1451	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZZ6_1452	COG0799	negative regulation of ribosome biogenesis
ZZ6_1453	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZZ6_1454	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZZ6_1457	COG0037	tRNA processing
ZZ6_1461	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ZZ6_1464	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ZZ6_1466	COG3386	PFAM SMP-30 Gluconolaconase
ZZ6_1467	COG1573	uracil-dna glycosylase
ZZ6_1468	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ZZ6_1469	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZZ6_1471	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZZ6_1472	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ZZ6_1474	COG0180	Tryptophanyl-tRNA synthetase
ZZ6_1476	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ZZ6_1479	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ZZ6_1482	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZZ6_1483	COG4774	siderophore transport
ZZ6_1487	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZZ6_1488	COG0706	membrane insertase activity
ZZ6_1489	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZZ6_1490	COG0594	ribonuclease P activity
ZZ6_1492	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZZ6_1496	COG0505	Belongs to the CarA family
ZZ6_1498	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZZ6_1504	COG0148	phosphopyruvate hydratase activity
ZZ6_1506	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZZ6_1507	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZZ6_1507	COG0022	dehydrogenase e1 component
ZZ6_1509	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZZ6_1509	COG3453	Protein conserved in bacteria
ZZ6_1511	COG0328	RNA-DNA hybrid ribonuclease activity
ZZ6_1512	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZZ6_1514	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZZ6_1515	COG1454	alcohol dehydrogenase
ZZ6_1517	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZZ6_1518	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZZ6_1519	COG1127	ABC transporter
ZZ6_1522	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZZ6_1525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZZ6_1526	COG0187	DNA topoisomerase II activity
ZZ6_1531	COG1294	oxidase, subunit
ZZ6_1532	COG1271	oxidase subunit
ZZ6_1534	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZZ6_1537	COG1742	UPF0060 membrane protein
ZZ6_1540	COG1051	belongs to the nudix hydrolase family
ZZ6_1541	COG4221	oxidoreductase activity
ZZ6_1542	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZZ6_1546	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZZ6_1547	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZZ6_1548	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZZ6_1549	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZZ6_1551	COG1657	PFAM Prenyltransferase squalene oxidase
ZZ6_1556	COG0629	single-stranded DNA binding
ZZ6_1559	COG0587	DNA-directed DNA polymerase activity
ZZ6_1563	COG0047	phosphoribosylformylglycinamidine synthase activity
ZZ6_1564	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZZ6_1565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZZ6_1565	COG0517	IMP dehydrogenase activity
ZZ6_1566	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZZ6_1570	COG1538	Outer membrane efflux protein
ZZ6_1572	COG4771	TonB-dependent receptor
ZZ6_1575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZZ6_1577	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ZZ6_1578	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZZ6_1579	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZZ6_1580	COG0072	phenylalanine-tRNA ligase activity
ZZ6_1580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZZ6_1581	COG5265	(ABC) transporter
ZZ6_1583	COG2890	protein-(glutamine-N5) methyltransferase activity
ZZ6_1584	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZZ6_1585	COG0124	histidyl-tRNA synthetase
ZZ6_1586	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZZ6_1589	COG0131	Imidazoleglycerol-phosphate dehydratase
ZZ6_1590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZZ6_1591	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZZ6_1592	COG0107	imidazoleglycerol-phosphate synthase activity
ZZ6_1593	COG0140	phosphoribosyl-ATP diphosphatase activity
ZZ6_1595	COG0531	amino acid
ZZ6_1596	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZZ6_1597	COG2096	Adenosyltransferase
ZZ6_1598	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZZ6_1603	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZZ6_1604	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZZ6_1605	COG2199	diguanylate cyclase activity
ZZ6_1605	COG2200	EAL domain
ZZ6_1609	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZZ6_1613	COG0045	succinate-CoA ligase (ADP-forming) activity
ZZ6_1616	COG0363	glucosamine-6-phosphate deaminase activity
ZZ6_1623	COG0814	amino acid
ZZ6_1631	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ZZ6_1632	COG2814	Major facilitator Superfamily
ZZ6_1637	COG0752	glycyl-tRNA synthetase alpha subunit
ZZ6_1639	COG2244	polysaccharide biosynthetic process
ZZ6_1643	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZZ6_1647	COG0495	leucyl-tRNA aminoacylation
ZZ6_1654	COG1597	lipid kinase activity
ZZ6_1655	COG2003	Belongs to the UPF0758 family
ZZ6_1656	COG0352	thiamine-phosphate diphosphorylase activity
ZZ6_1658	COG0612	Peptidase, M16
ZZ6_1659	COG0612	Peptidase, M16
ZZ6_1660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZZ6_1661	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZZ6_1662	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ZZ6_1664	COG0513	Belongs to the DEAD box helicase family
ZZ6_1666	COG1214	PFAM Peptidase M22, glycoprotease
ZZ6_1668	COG4957	zinc ion binding
ZZ6_1670	COG2193	ferroxidase activity
ZZ6_1673	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZZ6_1674	COG0596	Alpha beta hydrolase
ZZ6_1675	COG0784	Response regulator, receiver
ZZ6_1677	COG0739	heme binding
ZZ6_1678	COG0316	Belongs to the HesB IscA family
ZZ6_1679	COG0708	Exodeoxyribonuclease III
ZZ6_1691	COG0405	Gamma-glutamyltransferase
ZZ6_1695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZZ6_1696	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZZ6_1701	COG0571	ribonuclease III activity
ZZ6_1703	COG0300	oxidoreductase activity
ZZ6_1706	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZZ6_1707	COG3706	GGDEF domain
ZZ6_1708	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZZ6_1712	COG3961	Belongs to the TPP enzyme family
ZZ6_1713	COG0268	Binds directly to 16S ribosomal RNA
ZZ6_1719	COG0667	Aldo Keto reductase
ZZ6_1736	COG3654	unkown
ZZ6_1747	COG0667	Aldo Keto reductase
ZZ6_1748	COG2207	Transcriptional regulator
ZZ6_1750	COG3041	Addiction module toxin RelE StbE family
ZZ6_1751	COG1192	Involved in chromosome partitioning
ZZ6_1760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification