locus-tag	class	description
Zymop_0001	COG0268	Binds directly to 16S ribosomal RNA
Zymop_0002	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Zymop_0003	COG0488	(ABC) transporter
Zymop_0004	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Zymop_0004	COG2885	chlorophyll binding
Zymop_0005	COG4702	Belongs to the UPF0303 family
Zymop_0006	COG0670	Belongs to the BI1 family
Zymop_0008	COG1546	Belongs to the CinA family
Zymop_0008	COG1058	Belongs to the CinA family
Zymop_0009	COG0024	Methionine aminopeptidase
Zymop_0012	COG0308	aminopeptidase N
Zymop_0013	COG2321	neutral zinc metallopeptidase
Zymop_0014	COG0668	transmembrane transport
Zymop_0015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Zymop_0016	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Zymop_0017	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Zymop_0018	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Zymop_0018	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Zymop_0019	COG1660	Displays ATPase and GTPase activities
Zymop_0020	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Zymop_0021	COG0642	Histidine kinase
Zymop_0022	COG0745	RESPONSE REGULATOR receiver
Zymop_0024	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Zymop_0024	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Zymop_0026	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Zymop_0027	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Zymop_0029	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Zymop_0030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Zymop_0032	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Zymop_0032	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Zymop_0033	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Zymop_0036	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Zymop_0037	COG0321	lipoyl(octanoyl) transferase activity
Zymop_0039	COG0602	queuosine metabolic process
Zymop_0040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Zymop_0042	COG2261	transglycosylase associated protein
Zymop_0047	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Zymop_0048	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Zymop_0049	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Zymop_0051	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Zymop_0053	COG1012	belongs to the aldehyde dehydrogenase family
Zymop_0054	COG1648	precorrin-2 dehydrogenase activity
Zymop_0054	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Zymop_0058	COG0519	Catalyzes the synthesis of GMP from XMP
Zymop_0058	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Zymop_0059	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Zymop_0061	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Zymop_0062	COG1138	Cytochrome C-type biogenesis protein
Zymop_0063	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Zymop_0064	COG3088	subunit of a heme lyase
Zymop_0068	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Zymop_0070	COG2866	Carboxypeptidase
Zymop_0071	COG0588	phosphoglycerate mutase activity
Zymop_0072	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Zymop_0074	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Zymop_0075	COG0662	Cupin 2, conserved barrel domain protein
Zymop_0075	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Zymop_0078	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Zymop_0079	COG0302	gtp cyclohydrolase
Zymop_0080	COG4948	Mandelate Racemase Muconate Lactonizing
Zymop_0081	COG0359	binds to the 23S rRNA
Zymop_0082	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Zymop_0083	COG0360	Binds together with S18 to 16S ribosomal RNA
Zymop_0084	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Zymop_0087	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Zymop_0088	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Zymop_0089	COG0805	protein transport
Zymop_0093	COG0513	Belongs to the DEAD box helicase family
Zymop_0095	COG0166	Belongs to the GPI family
Zymop_0097	COG3158	transport of potassium into the cell
Zymop_0100	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Zymop_0101	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Zymop_0102	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Zymop_0104	COG0156	8-amino-7-oxononanoate synthase activity
Zymop_0105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Zymop_0106	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Zymop_0107	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Zymop_0107	COG0758	DNA mediated transformation
Zymop_0108	COG1754	DNA topoisomerase type I activity
Zymop_0108	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Zymop_0109	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Zymop_0110	COG0756	dUTP diphosphatase activity
Zymop_0111	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Zymop_0113	COG2226	methyltransferase
Zymop_0114	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Zymop_0119	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Zymop_0121	COG0129	dihydroxy-acid dehydratase activity
Zymop_0122	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Zymop_0122	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Zymop_0123	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Zymop_0124	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Zymop_0126	COG2205	protein histidine kinase activity
Zymop_0129	COG3724	N-succinylarginine dihydrolase activity
Zymop_0130	COG1472	Belongs to the glycosyl hydrolase 3 family
Zymop_0132	COG2971	BadF BadG BcrA BcrD
Zymop_0134	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Zymop_0135	COG1040	competence protein
Zymop_0136	COG0745	RESPONSE REGULATOR receiver
Zymop_0137	COG0704	Plays a role in the regulation of phosphate uptake
Zymop_0139	COG0688	phosphatidylethanolamine metabolic process
Zymop_0141	COG0052	Belongs to the universal ribosomal protein uS2 family
Zymop_0142	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Zymop_0143	COG0528	UMP kinase activity
Zymop_0144	COG0233	cytoplasmic translational termination
Zymop_0145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Zymop_0146	COG0575	Belongs to the CDS family
Zymop_0147	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Zymop_0148	COG0750	zinc metalloprotease
Zymop_0149	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Zymop_0151	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Zymop_0152	COG0254	rRNA binding
Zymop_0155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Zymop_0156	COG0440	acetolactate synthase activity
Zymop_0157	COG0028	Belongs to the TPP enzyme family
Zymop_0158	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Zymop_0159	COG3830	Belongs to the UPF0237 family
Zymop_0159	COG0560	Phosphoserine phosphatase
Zymop_0160	COG1858	cytochrome C peroxidase
Zymop_0161	COG0312	modulator of DNA gyrase
Zymop_0163	COG0288	reversible hydration of carbon dioxide
Zymop_0164	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Zymop_0165	COG2867	negative regulation of translational initiation
Zymop_0168	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Zymop_0168	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Zymop_0171	COG5000	phosphorelay sensor kinase activity
Zymop_0172	COG2204	response regulator
Zymop_0173	COG0776	regulation of translation
Zymop_0179	COG1968	undecaprenyl-diphosphatase activity
Zymop_0180	COG1573	uracil-dna glycosylase
Zymop_0181	COG1252	NADH dehydrogenase
Zymop_0182	COG2917	probably involved in intracellular septation
Zymop_0183	COG2807	transmembrane transport
Zymop_0185	COG1522	sequence-specific DNA binding
Zymop_0187	COG2205	protein histidine kinase activity
Zymop_0188	COG0802	atpase or kinase
Zymop_0189	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Zymop_0193	COG0557	exoribonuclease II activity
Zymop_0194	COG3956	TIGRFAM MazG family protein
Zymop_0195	COG0321	lipoyl(octanoyl) transferase activity
Zymop_0195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Zymop_0196	COG0084	hydrolase, TatD family'
Zymop_0198	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Zymop_0199	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Zymop_0200	COG1686	Belongs to the peptidase S11 family
Zymop_0202	COG2951	lytic endotransglycosylase activity
Zymop_0203	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Zymop_0204	COG0457	Tetratricopeptide repeat
Zymop_0209	COG0335	large ribosomal subunit rRNA binding
Zymop_0210	COG0336	Belongs to the RNA methyltransferase TrmD family
Zymop_0211	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Zymop_0212	COG0228	four-way junction DNA binding
Zymop_0213	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Zymop_0214	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Zymop_0215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Zymop_0216	COG0552	protein localization to endoplasmic reticulum
Zymop_0219	COG2166	iron-sulfur cluster assembly
Zymop_0220	COG2223	nitrite transmembrane transporter activity
Zymop_0224	COG1842	Phage shock protein A
Zymop_0226	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Zymop_0227	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Zymop_0230	COG0617	tRNA 3'-terminal CCA addition
Zymop_0231	COG5001	Diguanylate cyclase
Zymop_0232	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Zymop_0233	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Zymop_0234	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Zymop_0235	COG0581	inorganic phosphate transmembrane transporter activity
Zymop_0236	COG0573	inorganic phosphate transmembrane transporter activity
Zymop_0237	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Zymop_0239	COG1970	mechanosensitive ion channel activity
Zymop_0241	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Zymop_0242	COG0494	nUDIX hydrolase
Zymop_0243	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Zymop_0243	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Zymop_0246	COG0137	argininosuccinate synthase activity
Zymop_0248	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Zymop_0249	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Zymop_0255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Zymop_0256	COG1104	cysteine desulfurase activity
Zymop_0257	COG2945	thiolester hydrolase activity
Zymop_0258	COG0019	diaminopimelate decarboxylase activity
Zymop_0259	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Zymop_0264	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Zymop_0265	COG0424	maF-like protein
Zymop_0267	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Zymop_0270	COG0277	FAD linked oxidase domain protein
Zymop_0271	COG3781	membrane
Zymop_0272	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Zymop_0274	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Zymop_0275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Zymop_0275	COG0352	thiamine-phosphate diphosphorylase activity
Zymop_0275	COG0351	phosphomethylpyrimidine kinase
Zymop_0276	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Zymop_0277	COG3104	oligopeptide transport
Zymop_0279	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Zymop_0280	COG0009	L-threonylcarbamoyladenylate synthase
Zymop_0281	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Zymop_0282	COG0800	Aldolase
Zymop_0283	COG0668	transmembrane transport
Zymop_0287	COG0071	Belongs to the small heat shock protein (HSP20) family
Zymop_0290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Zymop_0291	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Zymop_0292	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Zymop_0295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Zymop_0296	COG4172	Belongs to the ABC transporter superfamily
Zymop_0297	COG0592	DNA-directed DNA polymerase activity
Zymop_0298	COG4206	TonB-dependent receptor
Zymop_0300	COG0667	Aldo Keto reductase
Zymop_0302	COG3394	polysaccharide catabolic process
Zymop_0305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Zymop_0307	COG2252	PERMEase
Zymop_0308	COG2814	Major facilitator Superfamily
Zymop_0309	COG1566	PFAM secretion protein HlyD family protein
Zymop_0311	COG1309	transcriptional regulator
Zymop_0312	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Zymop_0314	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Zymop_0316	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Zymop_0317	COG0723	plastoquinol--plastocyanin reductase activity
Zymop_0318	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Zymop_0319	COG0408	coproporphyrinogen oxidase activity
Zymop_0321	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Zymop_0322	COG0740	serine-type endopeptidase activity
Zymop_0324	COG0544	peptidyl-prolyl cis-trans isomerase activity
Zymop_0326	COG1621	beta-fructofuranosidase activity
Zymop_0328	COG1846	Transcriptional regulator
Zymop_0329	COG0402	S-adenosylhomocysteine deaminase activity
Zymop_0330	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
Zymop_0331	COG1448	Aminotransferase
Zymop_0339	COG3191	aminopeptidase activity
Zymop_0340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Zymop_0344	COG0653	protein targeting
Zymop_0345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Zymop_0350	COG3706	GGDEF domain
Zymop_0350	COG0745	RESPONSE REGULATOR receiver
Zymop_0352	COG2608	mercury ion transmembrane transporter activity
Zymop_0353	COG2217	Heavy metal translocating P-type atpase
Zymop_0354	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Zymop_0355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Zymop_0361	COG2943	transferase activity, transferring hexosyl groups
Zymop_0362	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Zymop_0364	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Zymop_0367	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Zymop_0367	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Zymop_0375	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Zymop_0376	COG1280	lysine exporter protein (LysE YggA)
Zymop_0379	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Zymop_0383	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Zymop_0384	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Zymop_0385	COG0840	transmembrane signaling receptor activity
Zymop_0386	COG2198	Histidine kinase
Zymop_0386	COG0643	Histidine kinase
Zymop_0387	COG2201	protein-glutamate methylesterase activity
Zymop_0390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Zymop_0391	COG0535	radical SAM domain protein
Zymop_0393	COG1657	PFAM Prenyltransferase squalene oxidase
Zymop_0394	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Zymop_0395	COG1562	ergosterol biosynthetic process
Zymop_0396	COG1562	ergosterol biosynthetic process
Zymop_0398	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Zymop_0401	COG0295	cytidine deaminase activity
Zymop_0402	COG0717	Belongs to the dCTP deaminase family
Zymop_0403	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Zymop_0406	COG1104	cysteine desulfurase activity
Zymop_0409	COG1722	exodeoxyribonuclease VII activity
Zymop_0410	COG0142	geranyltranstransferase activity
Zymop_0411	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Zymop_0412	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Zymop_0413	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Zymop_0414	COG0259	pyridoxamine-phosphate oxidase activity
Zymop_0416	COG0655	NAD(P)H dehydrogenase (quinone) activity
Zymop_0420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Zymop_0422	COG0018	arginyl-trna synthetase
Zymop_0423	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Zymop_0424	COG0038	chloride channel
Zymop_0426	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Zymop_0427	COG0849	cell division
Zymop_0428	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Zymop_0429	COG1181	Belongs to the D-alanine--D-alanine ligase family
Zymop_0430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Zymop_0431	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Zymop_0432	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Zymop_0434	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Zymop_0435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Zymop_0437	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Zymop_0440	COG0275	rRNA processing
Zymop_0444	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Zymop_0445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Zymop_0446	COG0720	synthase
Zymop_0449	COG1322	Protein conserved in bacteria
Zymop_0450	COG0242	peptide deformylase activity
Zymop_0451	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Zymop_0452	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Zymop_0453	COG0101	tRNA pseudouridine synthase activity
Zymop_0454	COG1872	DUF167
Zymop_0455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Zymop_0456	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Zymop_0458	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Zymop_0460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Zymop_0461	COG0540	Belongs to the ATCase OTCase family
Zymop_0465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Zymop_0466	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Zymop_0467	COG0154	amidase activity
Zymop_0468	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Zymop_0469	COG0583	DNA-binding transcription factor activity
Zymop_0470	COG1538	Outer membrane efflux protein
Zymop_0474	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Zymop_0476	COG0583	DNA-binding transcription factor activity
Zymop_0477	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Zymop_0478	COG2239	Acts as a magnesium transporter
Zymop_0479	COG0482	sulfurtransferase activity
Zymop_0481	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Zymop_0482	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Zymop_0486	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Zymop_0491	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Zymop_0494	COG0564	pseudouridine synthase activity
Zymop_0495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Zymop_0501	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Zymop_0505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Zymop_0506	COG0511	ligase activity, forming carbon-carbon bonds
Zymop_0507	COG0439	Biotin carboxylase
Zymop_0509	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Zymop_0510	COG0085	RNA polymerase activity
Zymop_0511	COG0222	ribosome binding
Zymop_0512	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Zymop_0513	COG0081	regulation of translation
Zymop_0514	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Zymop_0517	COG3590	peptidase
Zymop_0518	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Zymop_0519	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Zymop_0520	COG0741	lytic transglycosylase activity
Zymop_0523	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Zymop_0524	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Zymop_0526	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Zymop_0529	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Zymop_0530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Zymop_0531	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Zymop_0532	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Zymop_0534	COG0318	PFAM AMP-dependent synthetase and ligase
Zymop_0538	COG2076	Multidrug Resistance protein
Zymop_0540	COG1764	response to oxidative stress
Zymop_0541	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Zymop_0542	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Zymop_0543	COG0673	inositol 2-dehydrogenase activity
Zymop_0544	COG0679	Auxin Efflux Carrier
Zymop_0546	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Zymop_0547	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Zymop_0553	COG0473	3-isopropylmalate dehydrogenase activity
Zymop_0555	COG0583	DNA-binding transcription factor activity
Zymop_0557	COG1381	Involved in DNA repair and RecF pathway recombination
Zymop_0558	COG0322	excinuclease ABC activity
Zymop_0559	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Zymop_0560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Zymop_0562	COG0356	it plays a direct role in the translocation of protons across the membrane
Zymop_0567	COG2003	Belongs to the UPF0758 family
Zymop_0568	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Zymop_0569	COG0484	heat shock protein binding
Zymop_0570	COG0443	Heat shock 70 kDa protein
Zymop_0573	COG3138	arginine N-succinyltransferase
Zymop_0575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Zymop_0576	COG0726	polysaccharide deacetylase
Zymop_0577	COG0628	permease
Zymop_0579	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Zymop_0579	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Zymop_0580	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Zymop_0581	COG1684	flagellar biosynthetic protein fliR
Zymop_0582	COG1987	bacterial-type flagellum assembly
Zymop_0592	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Zymop_0594	COG1677	Flagellar hook-basal body complex protein FliE
Zymop_0595	COG2204	response regulator
Zymop_0600	COG0455	bacterial-type flagellum organization
Zymop_0606	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Zymop_0608	COG1558	bacterial-type flagellum-dependent cell motility
Zymop_0609	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Zymop_0610	COG1749	Flagellar hook protein flgE
Zymop_0611	COG4787	bacterial-type flagellum-dependent cell motility
Zymop_0612	COG4786	Flagellar basal body rod
Zymop_0613	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Zymop_0614	COG1706	bacterial-type flagellum-dependent cell motility
Zymop_0619	COG1360	Flagellar Motor Protein
Zymop_0621	COG0825	malonyl-CoA metabolic process
Zymop_0622	COG4974	Belongs to the 'phage' integrase family
Zymop_0625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Zymop_0626	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Zymop_0632	COG0284	orotidine-5'-phosphate decarboxylase activity
Zymop_0633	COG0135	phosphoribosylanthranilate isomerase activity
Zymop_0634	COG0133	tryptophan synthase activity
Zymop_0635	COG0159	tryptophan synthase activity
Zymop_0636	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Zymop_0638	COG2223	nitrite transmembrane transporter activity
Zymop_0639	COG1301	dicarboxylic acid transport
Zymop_0640	COG1187	pseudouridine synthase activity
Zymop_0641	COG0742	ribosomal rna small subunit methyltransferase
Zymop_0643	COG2999	glutathione oxidoreductase activity
Zymop_0644	COG1116	anion transmembrane transporter activity
Zymop_0645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Zymop_0646	COG3459	Glycosyltransferase 36 associated
Zymop_0647	COG2264	protein methyltransferase activity
Zymop_0652	COG1643	Atp-dependent helicase
Zymop_0653	COG0142	geranyltranstransferase activity
Zymop_0654	COG1605	Chorismate mutase
Zymop_0654	COG0287	Prephenate dehydrogenase
Zymop_0655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Zymop_0657	COG2133	pyrroloquinoline quinone binding
Zymop_0658	COG0779	Required for maturation of 30S ribosomal subunits
Zymop_0661	COG3064	Membrane
Zymop_0661	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Zymop_0662	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Zymop_0663	COG1435	thymidine kinase activity
Zymop_0664	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Zymop_0665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Zymop_0666	COG1185	polyribonucleotide nucleotidyltransferase activity
Zymop_0668	COG0038	chloride channel
Zymop_0669	COG0659	secondary active sulfate transmembrane transporter activity
Zymop_0670	COG2814	Major facilitator Superfamily
Zymop_0671	COG0134	indole-3-glycerol-phosphate synthase activity
Zymop_0674	COG0203	ribosomal protein L17
Zymop_0675	COG0202	RNA polymerase activity
Zymop_0676	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Zymop_0677	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Zymop_0678	COG0563	adenylate kinase activity
Zymop_0680	COG0200	Binds to the 23S rRNA
Zymop_0681	COG1841	ribosomal large subunit assembly
Zymop_0682	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Zymop_0683	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Zymop_0684	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Zymop_0685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Zymop_0686	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Zymop_0687	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Zymop_0688	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Zymop_0689	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Zymop_0690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Zymop_0691	COG0255	Belongs to the universal ribosomal protein uL29 family
Zymop_0692	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Zymop_0693	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Zymop_0694	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Zymop_0695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Zymop_0696	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Zymop_0697	COG0089	rRNA binding
Zymop_0698	COG0088	Forms part of the polypeptide exit tunnel
Zymop_0699	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Zymop_0700	COG0051	transcription antitermination factor activity, RNA binding
Zymop_0701	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Zymop_0702	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Zymop_0703	COG0049	tRNA binding
Zymop_0704	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Zymop_0706	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Zymop_0707	COG1607	acyl-coa hydrolase
Zymop_0708	COG0508	dehydrogenase complex catalyzes the overall conversion of
Zymop_0711	COG1956	GAF domain-containing protein
Zymop_0713	COG0564	pseudouridine synthase activity
Zymop_0718	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Zymop_0719	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Zymop_0724	COG0174	glutamine synthetase
Zymop_0725	COG0347	Belongs to the P(II) protein family
Zymop_0726	COG0006	proline dipeptidase activity
Zymop_0727	COG1770	oligopeptidase
Zymop_0731	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Zymop_0736	COG1494	fructose-1,6-bisphosphatase
Zymop_0738	COG5002	protein histidine kinase activity
Zymop_0742	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Zymop_0742	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Zymop_0745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Zymop_0747	COG0583	DNA-binding transcription factor activity
Zymop_0749	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Zymop_0750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Zymop_0751	COG0149	triose-phosphate isomerase activity
Zymop_0753	COG0504	CTP synthase activity
Zymop_0754	COG0442	prolyl-tRNA aminoacylation
Zymop_0756	COG1136	(ABC) transporter
Zymop_0757	COG1522	sequence-specific DNA binding
Zymop_0760	COG1160	GTP binding
Zymop_0761	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Zymop_0768	COG1372	Participates in initiation and elongation during chromosome replication
Zymop_0768	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Zymop_0769	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Zymop_0777	COG0194	GDP metabolic process
Zymop_0778	COG2171	N-acyltransferase activity
Zymop_0780	COG0316	Belongs to the HesB IscA family
Zymop_0781	COG2151	metal-sulfur cluster biosynthetic enzyme
Zymop_0782	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Zymop_0783	COG0719	Fe-S assembly protein
Zymop_0784	COG0396	ATPase activity
Zymop_0785	COG0719	Fe-S assembly protein
Zymop_0787	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Zymop_0788	COG0287	Prephenate dehydrogenase
Zymop_0792	COG2884	Cell division ATP-binding protein ftsE
Zymop_0795	COG2095	MarC family integral membrane protein
Zymop_0796	COG0187	DNA topoisomerase II activity
Zymop_0798	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Zymop_0799	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Zymop_0803	COG0248	Ppx GppA phosphatase
Zymop_0804	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Zymop_0805	COG3300	MHYT domain
Zymop_0805	COG5001	Diguanylate cyclase
Zymop_0825	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Zymop_0827	COG1621	beta-fructofuranosidase activity
Zymop_0828	COG1621	beta-fructofuranosidase activity
Zymop_0830	COG0837	glucose binding
Zymop_0831	COG0129	dihydroxy-acid dehydratase activity
Zymop_0832	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Zymop_0833	COG0477	Major facilitator Superfamily
Zymop_0834	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Zymop_0835	COG0343	queuine tRNA-ribosyltransferase activity
Zymop_0836	COG0556	nucleotide-excision repair
Zymop_0838	COG0772	Belongs to the SEDS family
Zymop_0841	COG1792	Involved in formation and maintenance of cell shape
Zymop_0843	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Zymop_0848	COG1678	Uncharacterized ACR, COG1678
Zymop_0849	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Zymop_0850	COG1923	regulation of RNA biosynthetic process
Zymop_0851	COG0004	ammonium transporteR
Zymop_0853	COG0312	modulator of DNA gyrase
Zymop_0858	COG1192	Involved in chromosome partitioning
Zymop_0859	COG0352	thiamine-phosphate diphosphorylase activity
Zymop_0860	COG3108	Peptidase M15
Zymop_0861	COG0483	inositol monophosphate 1-phosphatase activity
Zymop_0862	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Zymop_0863	COG0626	cystathionine gamma-synthase activity
Zymop_0864	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Zymop_0866	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Zymop_0867	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Zymop_0868	COG0196	riboflavin kinase activity
Zymop_0874	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Zymop_0878	COG1028	Short-chain dehydrogenase reductase Sdr
Zymop_0882	COG0667	Aldo Keto reductase
Zymop_0883	COG2207	Transcriptional regulator
Zymop_0884	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Zymop_0887	COG1570	exodeoxyribonuclease VII activity
Zymop_0888	COG0151	Belongs to the GarS family
Zymop_0890	COG1253	flavin adenine dinucleotide binding
Zymop_0891	COG0590	tRNA wobble adenosine to inosine editing
Zymop_0892	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Zymop_0893	COG2814	Major facilitator Superfamily
Zymop_0894	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Zymop_0895	COG2733	membrane
Zymop_0898	COG1538	Outer membrane efflux protein
Zymop_0900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Zymop_0902	COG1228	amidohydrolase
Zymop_0903	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Zymop_0904	COG1278	Cold shock
Zymop_0908	COG1137	ATPase activity
Zymop_0909	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Zymop_0910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Zymop_0911	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Zymop_0912	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Zymop_0913	COG4133	protoheme IX ABC transporter activity
Zymop_0914	COG2205	protein histidine kinase activity
Zymop_0915	COG0745	RESPONSE REGULATOR receiver
Zymop_0916	COG0277	FAD linked oxidase domain protein
Zymop_0923	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Zymop_0924	COG0783	Belongs to the Dps family
Zymop_0925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Zymop_0926	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Zymop_0927	COG0776	regulation of translation
Zymop_0929	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Zymop_0930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Zymop_0931	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Zymop_0932	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Zymop_0933	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Zymop_0934	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Zymop_0935	COG0489	protein tyrosine kinase activity
Zymop_0936	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Zymop_0937	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Zymop_0939	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Zymop_0940	COG4139	cobalamin transport
Zymop_0942	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Zymop_0942	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Zymop_0943	COG4221	oxidoreductase activity
Zymop_0944	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Zymop_0945	COG2813	Specifically methylates the guanine in position
Zymop_0945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Zymop_0946	COG1329	Transcriptional regulator
Zymop_0947	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Zymop_0948	COG4581	dead DEAH box helicase
Zymop_0949	COG0739	heme binding
Zymop_0952	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Zymop_0953	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Zymop_0955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Zymop_0956	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Zymop_0967	COG0840	transmembrane signaling receptor activity
Zymop_0968	COG0840	transmembrane signaling receptor activity
Zymop_0970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Zymop_0971	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Zymop_0973	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Zymop_0975	COG0860	N-Acetylmuramoyl-L-alanine amidase
Zymop_0976	COG1530	ribonuclease E activity
Zymop_0980	COG1760	l-serine dehydratase
Zymop_0982	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Zymop_0983	COG0215	cysteine-tRNA ligase activity
Zymop_0985	COG0488	(ABC) transporter
Zymop_0987	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Zymop_0988	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Zymop_0989	COG1830	Aldolase
Zymop_0990	COG0126	phosphoglycerate kinase activity
Zymop_0991	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Zymop_0996	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Zymop_0998	COG0584	glycerophosphoryl diester phosphodiesterase
Zymop_0999	COG0583	DNA-binding transcription factor activity
Zymop_1000	COG0129	dihydroxy-acid dehydratase activity
Zymop_1008	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Zymop_1009	COG1518	maintenance of DNA repeat elements
Zymop_1012	COG1857	crispr-associated protein
Zymop_1015	COG1203	CRISPR-associated helicase, Cas3
Zymop_1016	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Zymop_1017	COG1794	racemase activity, acting on amino acids and derivatives
Zymop_1018	COG1522	sequence-specific DNA binding
Zymop_1023	COG2249	NAD(P)H dehydrogenase (quinone) activity
Zymop_1024	COG0583	DNA-binding transcription factor activity
Zymop_1026	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Zymop_1027	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Zymop_1028	COG2244	polysaccharide biosynthetic process
Zymop_1030	COG1028	Short-chain dehydrogenase reductase Sdr
Zymop_1031	COG0625	glutathione transferase activity
Zymop_1038	COG2885	chlorophyll binding
Zymop_1039	COG0823	Involved in the tonB-independent uptake of proteins
Zymop_1041	COG0848	biopolymer transport protein
Zymop_1043	COG0824	Thioesterase
Zymop_1045	COG2255	four-way junction helicase activity
Zymop_1046	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Zymop_1048	COG0632	four-way junction helicase activity
Zymop_1049	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Zymop_1050	COG0217	transcriptional regulatory protein
Zymop_1051	COG3750	Belongs to the UPF0335 family
Zymop_1052	COG0469	pyruvate kinase activity
Zymop_1053	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Zymop_1057	COG1131	(ABC) transporter
Zymop_1058	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Zymop_1059	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Zymop_1061	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Zymop_1064	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Zymop_1066	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Zymop_1069	COG0546	phosphoglycolate phosphatase activity
Zymop_1070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Zymop_1072	COG0730	response to heat
Zymop_1074	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Zymop_1075	COG4771	TonB-dependent receptor
Zymop_1076	COG0371	Dehydrogenase
Zymop_1078	COG2271	Major facilitator Superfamily
Zymop_1079	COG4716	Myosin-crossreactive antigen
Zymop_1082	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Zymop_1083	COG0175	sulfate reduction
Zymop_1084	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Zymop_1084	COG1648	precorrin-2 dehydrogenase activity
Zymop_1085	COG0175	sulfate reduction
Zymop_1091	COG1230	cation diffusion facilitator family transporter
Zymop_1097	COG2999	glutathione oxidoreductase activity
Zymop_1101	COG4535	Mg2 and Co2 transporter CorC
Zymop_1102	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Zymop_1104	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Zymop_1105	COG0835	chemotaxis
Zymop_1107	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Zymop_1108	COG2201	protein-glutamate methylesterase activity
Zymop_1109	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Zymop_1110	COG2198	Histidine kinase
Zymop_1110	COG0643	Histidine kinase
Zymop_1112	COG0840	transmembrane signaling receptor activity
Zymop_1114	COG1028	Short-chain dehydrogenase reductase Sdr
Zymop_1120	COG0066	3-isopropylmalate dehydratase activity
Zymop_1121	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Zymop_1123	COG2814	Major facilitator Superfamily
Zymop_1124	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Zymop_1125	COG4774	siderophore transport
Zymop_1127	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Zymop_1133	COG0512	Glutamine amidotransferase of anthranilate synthase
Zymop_1134	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Zymop_1135	COG1959	2 iron, 2 sulfur cluster binding
Zymop_1136	COG1151	hydroxylamine reductase activity
Zymop_1138	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Zymop_1139	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Zymop_1140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Zymop_1141	COG1420	regulation of RNA biosynthetic process
Zymop_1142	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Zymop_1144	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Zymop_1147	COG1139	Iron-sulfur cluster binding protein
Zymop_1148	COG0247	lactate metabolic process
Zymop_1149	COG0138	bifunctional purine biosynthesis protein purh
Zymop_1151	COG4771	TonB-dependent receptor
Zymop_1152	COG2983	Belongs to the UPF0260 family
Zymop_1155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Zymop_1156	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Zymop_1157	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Zymop_1158	COG0237	dephospho-CoA kinase activity
Zymop_1159	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Zymop_1160	COG0424	maF-like protein
Zymop_1164	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Zymop_1166	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Zymop_1169	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Zymop_1169	COG2169	Transcriptional regulator
Zymop_1170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Zymop_1171	COG1621	beta-fructofuranosidase activity
Zymop_1172	COG0445	tRNA wobble uridine modification
Zymop_1173	COG0357	Ribosomal RNA small subunit methyltransferase G
Zymop_1174	COG1192	Involved in chromosome partitioning
Zymop_1175	COG1475	DNA binding
Zymop_1176	COG0477	Major facilitator Superfamily
Zymop_1182	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Zymop_1183	COG0372	Belongs to the citrate synthase family
Zymop_1184	COG2205	protein histidine kinase activity
Zymop_1189	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Zymop_1189	COG0438	transferase activity, transferring glycosyl groups
Zymop_1190	COG0497	DNA recombination
Zymop_1192	COG0459	protein refolding
Zymop_1193	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Zymop_1194	COG0616	signal peptide processing
Zymop_1197	COG1368	sulfuric ester hydrolase activity
Zymop_1202	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Zymop_1203	COG0156	8-amino-7-oxononanoate synthase activity
Zymop_1205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Zymop_1205	COG4106	trans-aconitate 2-methyltransferase activity
Zymop_1206	COG4974	Belongs to the 'phage' integrase family
Zymop_1207	COG0189	ligase activity
Zymop_1209	COG0012	GTP binding
Zymop_1210	COG0193	aminoacyl-tRNA hydrolase activity
Zymop_1211	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Zymop_1214	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Zymop_1215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Zymop_1216	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Zymop_1217	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Zymop_1218	COG0181	hydroxymethylbilane synthase activity
Zymop_1221	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Zymop_1222	COG0416	fatty acid biosynthetic process
Zymop_1223	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Zymop_1225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Zymop_1230	COG0612	Peptidase, M16
Zymop_1232	COG2226	methyltransferase
Zymop_1233	COG3180	Ammonia monooxygenase
Zymop_1234	COG1902	pentaerythritol trinitrate reductase activity
Zymop_1235	COG1285	pathogenesis
Zymop_1236	COG2814	Major facilitator Superfamily
Zymop_1237	COG0657	acetylesterase activity
Zymop_1238	COG3180	Ammonia monooxygenase
Zymop_1240	COG0113	porphobilinogen synthase activity
Zymop_1241	COG0525	valine-tRNA ligase activity
Zymop_1246	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Zymop_1252	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Zymop_1257	COG1028	Short-chain dehydrogenase reductase Sdr
Zymop_1267	COG2084	Dehydrogenase
Zymop_1269	COG0716	FMN binding
Zymop_1275	COG1120	ATPase activity
Zymop_1276	COG1064	alcohol dehydrogenase
Zymop_1277	COG1733	regulation of RNA biosynthetic process
Zymop_1278	COG2824	Alkylphosphonate utilization operon protein PhnA
Zymop_1279	COG0673	inositol 2-dehydrogenase activity
Zymop_1282	COG4657	Part of a membrane complex involved in electron transport
Zymop_1289	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Zymop_1289	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Zymop_1292	COG3585	molybdate ion transport
Zymop_1293	COG3585	molybdate ion transport
Zymop_1294	COG2837	iron assimilation
Zymop_1299	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Zymop_1300	COG1104	cysteine desulfurase activity
Zymop_1302	COG0316	Belongs to the HesB IscA family
Zymop_1306	COG1433	Dinitrogenase iron-molybdenum cofactor
Zymop_1307	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Zymop_1308	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Zymop_1309	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Zymop_1310	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Zymop_1311	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Zymop_1313	COG5554	nitrogen fixation
Zymop_1314	COG5554	nitrogen fixation
Zymop_1315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Zymop_1316	COG0535	radical SAM domain protein
Zymop_1317	COG3604	Transcriptional regulator
Zymop_1319	COG4657	Part of a membrane complex involved in electron transport
Zymop_1327	COG0546	phosphoglycolate phosphatase activity
Zymop_1328	COG0531	amino acid
Zymop_1331	COG0776	regulation of translation
Zymop_1332	COG0539	negative regulation of cytoplasmic translation
Zymop_1333	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Zymop_1334	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Zymop_1337	COG1132	(ABC) transporter
Zymop_1341	COG0668	transmembrane transport
Zymop_1348	COG1733	regulation of RNA biosynthetic process
Zymop_1350	COG0656	L-ascorbic acid biosynthetic process
Zymop_1352	COG1979	alcohol dehydrogenase
Zymop_1354	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Zymop_1355	COG0792	nuclease activity
Zymop_1357	COG2989	Protein conserved in bacteria
Zymop_1360	COG0019	diaminopimelate decarboxylase activity
Zymop_1362	COG0165	Argininosuccinate lyase
Zymop_1363	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Zymop_1364	COG3265	gluconokinase activity
Zymop_1365	COG2610	gluconate transmembrane transporter activity
Zymop_1366	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Zymop_1367	COG1012	belongs to the aldehyde dehydrogenase family
Zymop_1371	COG2853	Lipoprotein
Zymop_1372	COG2226	methyltransferase
Zymop_1373	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Zymop_1375	COG0646	methionine synthase
Zymop_1375	COG1410	methionine synthase
Zymop_1377	COG0481	GTPase activity
Zymop_1379	COG3275	phosphorelay sensor kinase activity
Zymop_1380	COG3279	Response regulator of the LytR AlgR family
Zymop_1385	COG0583	DNA-binding transcription factor activity
Zymop_1387	COG1045	serine acetyltransferase
Zymop_1390	COG0436	Aminotransferase
Zymop_1391	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Zymop_1392	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Zymop_1395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Zymop_1397	COG1758	RNA polymerase activity
Zymop_1398	COG1940	carbohydrate kinase activity
Zymop_1404	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Zymop_1406	COG0628	permease
Zymop_1408	COG0736	holo-[acyl-carrier-protein] synthase activity
Zymop_1409	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Zymop_1410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Zymop_1413	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Zymop_1415	COG1929	Belongs to the glycerate kinase type-1 family
Zymop_1416	COG1674	ftsk spoiiie
Zymop_1419	COG0708	Exodeoxyribonuclease III
Zymop_1420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Zymop_1420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Zymop_1423	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Zymop_1424	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Zymop_1425	COG1295	ribonuclease BN
Zymop_1426	COG0484	heat shock protein binding
Zymop_1428	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Zymop_1429	COG0354	folic acid binding
Zymop_1430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Zymop_1432	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Zymop_1443	COG0656	L-ascorbic acid biosynthetic process
Zymop_1447	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Zymop_1449	COG0793	Belongs to the peptidase S41A family
Zymop_1451	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Zymop_1452	COG0799	negative regulation of ribosome biogenesis
Zymop_1453	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Zymop_1454	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Zymop_1457	COG0037	tRNA processing
Zymop_1461	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Zymop_1463	COG2070	2-Nitropropane dioxygenase
Zymop_1464	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Zymop_1466	COG3386	PFAM SMP-30 Gluconolaconase
Zymop_1467	COG1573	uracil-dna glycosylase
Zymop_1468	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Zymop_1469	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Zymop_1471	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Zymop_1472	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Zymop_1475	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Zymop_1477	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Zymop_1479	COG0180	Tryptophanyl-tRNA synthetase
Zymop_1481	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Zymop_1483	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Zymop_1484	COG0706	membrane insertase activity
Zymop_1485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Zymop_1486	COG0594	ribonuclease P activity
Zymop_1488	COG1720	tRNA m6t6A37 methyltransferase activity
Zymop_1489	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Zymop_1493	COG0505	Belongs to the CarA family
Zymop_1495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Zymop_1501	COG0148	phosphopyruvate hydratase activity
Zymop_1505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Zymop_1506	COG0022	dehydrogenase e1 component
Zymop_1506	COG0508	dehydrogenase complex catalyzes the overall conversion of
Zymop_1508	COG3453	Protein conserved in bacteria
Zymop_1508	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Zymop_1509	COG1335	isochorismatase
Zymop_1510	COG0328	RNA-DNA hybrid ribonuclease activity
Zymop_1511	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Zymop_1513	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Zymop_1514	COG1454	alcohol dehydrogenase
Zymop_1516	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Zymop_1517	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Zymop_1518	COG1127	ABC transporter
Zymop_1519	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Zymop_1522	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Zymop_1523	COG0187	DNA topoisomerase II activity
Zymop_1526	COG0667	Aldo Keto reductase
Zymop_1531	COG1028	Short-chain dehydrogenase reductase Sdr
Zymop_1533	COG2814	Major facilitator Superfamily
Zymop_1538	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Zymop_1539	COG0803	Belongs to the bacterial solute-binding protein 9 family
Zymop_1541	COG1294	oxidase, subunit
Zymop_1542	COG1271	oxidase subunit
Zymop_1544	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Zymop_1549	COG1051	belongs to the nudix hydrolase family
Zymop_1550	COG0300	oxidoreductase activity
Zymop_1551	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Zymop_1554	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Zymop_1555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Zymop_1556	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Zymop_1557	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Zymop_1562	COG0629	single-stranded DNA binding
Zymop_1565	COG0587	DNA-directed DNA polymerase activity
Zymop_1567	COG0047	phosphoribosylformylglycinamidine synthase activity
Zymop_1568	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Zymop_1569	COG0517	IMP dehydrogenase activity
Zymop_1569	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Zymop_1570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Zymop_1573	COG1538	Outer membrane efflux protein
Zymop_1575	COG4206	TonB-dependent receptor
Zymop_1578	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Zymop_1580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Zymop_1581	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Zymop_1582	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Zymop_1583	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Zymop_1583	COG0072	phenylalanine-tRNA ligase activity
Zymop_1584	COG5265	(ABC) transporter
Zymop_1586	COG2890	protein-(glutamine-N5) methyltransferase activity
Zymop_1587	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Zymop_1588	COG0124	histidyl-tRNA synthetase
Zymop_1589	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Zymop_1592	COG0131	Imidazoleglycerol-phosphate dehydratase
Zymop_1593	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Zymop_1594	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Zymop_1595	COG0107	imidazoleglycerol-phosphate synthase activity
Zymop_1596	COG0140	phosphoribosyl-ATP diphosphatase activity
Zymop_1598	COG0531	amino acid
Zymop_1599	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Zymop_1601	COG2096	Adenosyltransferase
Zymop_1602	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Zymop_1606	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Zymop_1607	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Zymop_1611	COG0045	succinate-CoA ligase (ADP-forming) activity
Zymop_1612	COG2086	electron transfer activity
Zymop_1622	COG0246	Mannitol dehydrogenase
Zymop_1626	COG0752	glycyl-tRNA synthetase alpha subunit
Zymop_1627	COG0751	glycine-tRNA ligase activity
Zymop_1630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Zymop_1632	COG0495	leucyl-tRNA aminoacylation
Zymop_1638	COG1566	PFAM secretion protein HlyD family protein
Zymop_1640	COG2003	Belongs to the UPF0758 family
Zymop_1643	COG0612	Peptidase, M16
Zymop_1644	COG0612	Peptidase, M16
Zymop_1645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Zymop_1646	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Zymop_1649	COG0513	Belongs to the DEAD box helicase family
Zymop_1653	COG4957	zinc ion binding
Zymop_1659	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Zymop_1660	COG0596	Alpha beta hydrolase
Zymop_1661	COG0784	Response regulator, receiver
Zymop_1663	COG0739	heme binding
Zymop_1665	COG0708	Exodeoxyribonuclease III
Zymop_1677	COG0405	Gamma-glutamyltransferase
Zymop_1681	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Zymop_1682	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Zymop_1687	COG0571	ribonuclease III activity
Zymop_1695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Zymop_1696	COG3706	GGDEF domain
Zymop_1697	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Zymop_1699	COG3961	Belongs to the TPP enzyme family
Zymop_1703	COG1192	Involved in chromosome partitioning
Zymop_1704	COG3041	Addiction module toxin RelE StbE family
Zymop_1706	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Zymop_1711	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Zymop_1712	COG1518	maintenance of DNA repeat elements
Zymop_2045	COG0732	type I restriction modification DNA specificity domain
Zymop_2056	COG2130	NADP-dependent
Zymop_2065	COG3654	unkown
Zymop_2071	COG3077	Addiction module antitoxin, RelB DinJ family