locus-tag	class	description
HIMB5_00000010	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HIMB5_00000020	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HIMB5_00000030	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HIMB5_00000040	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HIMB5_00000050	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HIMB5_00000060	ENOG4105CSU	acyl-Coa dehydrogenase
HIMB5_00000090	ENOG4107TNW	(Aminomethyl transferase) family protein
HIMB5_00000100	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HIMB5_00000140	ENOG4105E33	succinate dehydrogenase
HIMB5_00000150	ENOG4105C26	Dehydrogenase
HIMB5_00000160	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HIMB5_00000170	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HIMB5_00000180	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HIMB5_00000190	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HIMB5_00000200	ENOG4105C7S	Dehydrogenase
HIMB5_00000210	ENOG4107QN2	dihydrolipoyl dehydrogenase
HIMB5_00000240	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HIMB5_00000250	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HIMB5_00000260	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HIMB5_00000270	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HIMB5_00000280	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HIMB5_00000290	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HIMB5_00000300	ENOG4105CN1	protease
HIMB5_00000320	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HIMB5_00000330	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HIMB5_00000340	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HIMB5_00000350	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HIMB5_00000360	ENOG4105K46	50S ribosomal protein l27
HIMB5_00000370	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HIMB5_00000380	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HIMB5_00000390	ENOG4105DWV	Homoserine O-trans-acetylase
HIMB5_00000400	ENOG4105DWV	Homoserine O-trans-acetylase
HIMB5_00000410	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HIMB5_00000430	ENOG4107RDJ	Sulfotransferase
HIMB5_00000450	ENOG4105EYM	Major Facilitator superfamily
HIMB5_00000460	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HIMB5_00000470	ENOG4105DK7	lysyl-tRNA synthetase
HIMB5_00000480	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HIMB5_00000490	ENOG4105KDC	50s ribosomal protein l28
HIMB5_00000500	ENOG4105EX9	Membrane
HIMB5_00000530	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HIMB5_00000540	ENOG4108UYB	regulatoR
HIMB5_00000560	ENOG4105C2M	dna polymerase I
HIMB5_00000570	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HIMB5_00000580	ENOG4105EB3	Histidine kinase
HIMB5_00000590	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HIMB5_00000600	ENOG4105K8N	protein family UPF0079, ATPase
HIMB5_00000620	ENOG4108S0S	Nucleotidyl transferase
HIMB5_00000630	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HIMB5_00000660	ENOG4105BZS	acriflavin resistance protein
HIMB5_00000690	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HIMB5_00000750	ENOG4105C7N	Xanthine uracil vitamin C permease
HIMB5_00000810	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HIMB5_00000820	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HIMB5_00000860	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HIMB5_00000870	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HIMB5_00000900	ENOG4108VW9	Membrane
HIMB5_00000910	ENOG4105CI3	gtp-binding protein typa
HIMB5_00000920	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HIMB5_00000930	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HIMB5_00000950	ENOG4105DTN	riboflavin biosynthesis protein ribF
HIMB5_00000960	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HIMB5_00000970	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HIMB5_00000990	ENOG4107QYV	phosphohexose isomerase
HIMB5_00001040	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HIMB5_00001050	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HIMB5_00001060	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HIMB5_00001070	ENOG4105BZ1	(ABC) transporter
HIMB5_00001080	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HIMB5_00001100	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HIMB5_00001110	ENOG4105EUB	pirin domain protein
HIMB5_00001130	ENOG4105KVH	Transcriptional regulator
HIMB5_00001170	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HIMB5_00001180	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HIMB5_00001200	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HIMB5_00001210	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HIMB5_00001230	ENOG4105D98	threonine synthase
HIMB5_00001260	ENOG4105CUV	Homoserine Kinase
HIMB5_00001270	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HIMB5_00001300	ENOG4105FE1	phytoene synthase
HIMB5_00001310	ENOG4105EWK	phytoene
HIMB5_00001330	ENOG4108VHN	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HIMB5_00001340	ENOG4105VD1	ATP synthase subunit C
HIMB5_00001350	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HIMB5_00001360	ENOG41081E4	ATP synthase F0 subunit I
HIMB5_00001370	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HIMB5_00001400	ENOG4105CEN	a g-specific adenine glycosylase
HIMB5_00001420	ENOG4105CEC	DNA methylase N-4 N-6
HIMB5_00001430	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HIMB5_00001460	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HIMB5_00001480	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HIMB5_00001490	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HIMB5_00001500	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HIMB5_00001510	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HIMB5_00001530	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HIMB5_00001540	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HIMB5_00001550	ENOG4105C3G	gtp-binding protein
HIMB5_00001560	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HIMB5_00001570	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HIMB5_00001580	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HIMB5_00001590	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HIMB5_00001620	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HIMB5_00001640	ENOG4105E0F	Histidine kinase
HIMB5_00001650	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HIMB5_00001680	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HIMB5_00001690	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HIMB5_00001710	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
HIMB5_00001720	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HIMB5_00001740	ENOG4105C3M	thioredoxin reductase
HIMB5_00001780	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HIMB5_00001800	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HIMB5_00001810	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HIMB5_00001880	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HIMB5_00001900	ENOG4107YUR	Cell division protein mraZ
HIMB5_00001920	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HIMB5_00001940	ENOG4105CJN	penicillin-binding protein
HIMB5_00001960	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HIMB5_00001970	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HIMB5_00001990	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HIMB5_00002000	ENOG4105DFU	Cell wall formation (By similarity)
HIMB5_00002010	ENOG4105D4A	Cell wall formation (By similarity)
HIMB5_00002020	ENOG4105CPF	Cell wall formation (By similarity)
HIMB5_00002060	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB5_00002070	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIMB5_00002080	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HIMB5_00002090	ENOG4105DC7	peptidase M24
HIMB5_00002120	ENOG4105C9Q	fumarate hydratase class II
HIMB5_00002140	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB5_00002170	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HIMB5_00002190	ENOG4107Z7P	Ferredoxin
HIMB5_00002200	ENOG4105CAY	ferredoxin--nadp reductase
HIMB5_00002210	ENOG4105CYM	Glutathione S-transferase
HIMB5_00002220	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HIMB5_00002240	ENOG4105CKK	Glycosyl transferase, family 2
HIMB5_00002270	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HIMB5_00002310	ENOG4105DBI	uridine monophosphokinase
HIMB5_00002330	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HIMB5_00002340	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HIMB5_00002360	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HIMB5_00002370	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HIMB5_00002390	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HIMB5_00002420	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HIMB5_00002450	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HIMB5_00002480	ENOG4105E7W	lamb ycsf family protein
HIMB5_00002490	ENOG4105P4J	Allophanate hydrolase, subunit 1
HIMB5_00002520	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB5_00002530	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HIMB5_00002540	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HIMB5_00002570	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HIMB5_00002590	ENOG4105E1F	short-chain dehydrogenase reductase
HIMB5_00002600	ENOG4105KAV	tspo and mbr like protein
HIMB5_00002610	ENOG4105FC8	fad dependent oxidoreductase
HIMB5_00002620	ENOG4105CNG	UPF0061 protein
HIMB5_00002630	ENOG4108IEG	Formate dehydrogenase Alpha subunit
HIMB5_00002640	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
HIMB5_00002650	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HIMB5_00002680	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HIMB5_00002750	ENOG4105DC7	peptidase M24
HIMB5_00002800	ENOG4105D7Z	glutathione synthase
HIMB5_00002810	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
HIMB5_00002820	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HIMB5_00002850	ENOG4105CDU	Replicative dna helicase
HIMB5_00002860	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HIMB5_00002870	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HIMB5_00002880	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HIMB5_00002890	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HIMB5_00002900	ENOG4105CHR	reductase
HIMB5_00002910	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HIMB5_00002920	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HIMB5_00002930	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HIMB5_00002940	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HIMB5_00002950	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HIMB5_00002960	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HIMB5_00002990	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HIMB5_00003010	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HIMB5_00003050	ENOG4105C9M	aspartyl-trna synthetase
HIMB5_00003060	ENOG4107RTZ	reductase
HIMB5_00003090	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HIMB5_00003100	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HIMB5_00003110	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HIMB5_00003130	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HIMB5_00003140	ENOG4105C03	ribonuclease
HIMB5_00003150	ENOG4108JQC	penicillin-binding protein 1A
HIMB5_00003160	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HIMB5_00003180	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HIMB5_00003190	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HIMB5_00003200	ENOG4105DHZ	alpha beta
HIMB5_00003210	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HIMB5_00003230	ENOG4105C3K	feS assembly ATPase SufC
HIMB5_00003240	ENOG4105JRK	feS assembly protein SufD
HIMB5_00003250	ENOG4105C9B	Cysteine desulfurase
HIMB5_00003260	ENOG4108UNV	SUF system FeS assembly protein, NifU family
HIMB5_00003280	ENOG4108Z4V	iron-sulfur cluster assembly
HIMB5_00003300	ENOG4105C5F	glutamine synthetase
HIMB5_00003310	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HIMB5_00003370	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HIMB5_00003450	ENOG4107XAN	XdhC and CoxI family
HIMB5_00003470	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
HIMB5_00003480	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
HIMB5_00003490	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HIMB5_00003500	ENOG4108ZAF	Molybdopterin
HIMB5_00003530	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HIMB5_00003540	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HIMB5_00003570	ENOG4105C26	Dehydrogenase
HIMB5_00003580	ENOG4106517	Short-chain dehydrogenase reductase Sdr
HIMB5_00003590	ENOG4105DKQ	ROK family
HIMB5_00003610	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
HIMB5_00003640	ENOG4105FGE	Short-chain dehydrogenase reductase Sdr
HIMB5_00003660	ENOG4105C01	Dihydroxy-acid dehydratase
HIMB5_00003670	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
HIMB5_00003710	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HIMB5_00003720	ENOG4107QIV	Cytochrome c biogenesis protein
HIMB5_00003730	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HIMB5_00003810	ENOG4105C6T	cysteine synthase
HIMB5_00003820	ENOG4105D7W	serine acetyltransferase
HIMB5_00003860	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HIMB5_00003880	ENOG4105DG4	malate L-lactate dehydrogenase
HIMB5_00003900	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HIMB5_00003910	ENOG4108IY8	ABC, transporter
HIMB5_00003930	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HIMB5_00003940	ENOG4105DCF	alanine dehydrogenase
HIMB5_00003960	ENOG4105C09	Bile acid
HIMB5_00004010	ENOG4105M0T	TPR Repeat-Containing Protein
HIMB5_00004090	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HIMB5_00004110	ENOG4107RES	phosphoglycerol transferase I
HIMB5_00004130	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HIMB5_00004140	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HIMB5_00004150	ENOG4107X42	5-methylthioadenosine S-adenosylhomocysteine nucleosidase
HIMB5_00004160	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
HIMB5_00004250	ENOG4108Z0R	Transferase
HIMB5_00004280	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HIMB5_00004300	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HIMB5_00004320	ENOG4105HF0	Membrane
HIMB5_00004350	ENOG4107QKV	phosphomannomutase
HIMB5_00004360	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HIMB5_00004370	ENOG4107R25	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HIMB5_00004450	ENOG4107TNW	(Aminomethyl transferase) family protein
HIMB5_00004500	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HIMB5_00004510	ENOG4108UJV	acyl-CoA thioesterase i
HIMB5_00004540	ENOG4108RVA	ribokinase
HIMB5_00004600	ENOG4108JQ7	(ABC) transporter
HIMB5_00004620	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HIMB5_00004630	ENOG4105DEF	Extracellular solute-binding protein, family 5
HIMB5_00004660	ENOG4108V0E	nucleoside 2-deoxyribosyltransferase YtoQ
HIMB5_00004740	ENOG4108VPT	UPF0234 protein
HIMB5_00004750	ENOG4105DZP	Membrane-associated zinc metalloprotease
HIMB5_00004760	ENOG4105K70	DNA-binding protein
HIMB5_00004780	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HIMB5_00004800	ENOG4105C72	UPF0176 protein
HIMB5_00004850	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HIMB5_00004870	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HIMB5_00004890	ENOG4105C28	cystathionine
HIMB5_00004930	ENOG4105DDQ	anthranilate synthase
HIMB5_00004950	ENOG4105K59	histidine triad (HIT) protein
HIMB5_00005040	ENOG4105VP7	SAF domain protein
HIMB5_00005120	ENOG4105EXC	Acyl-transferase
HIMB5_00005160	ENOG4105CHR	reductase
HIMB5_00005170	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
HIMB5_00005180	ENOG4108ZCF	integral membrane protein
HIMB5_00005220	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HIMB5_00005230	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HIMB5_00005270	ENOG4107YD3	Thioesterase
HIMB5_00005350	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HIMB5_00005360	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HIMB5_00005370	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HIMB5_00005380	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HIMB5_00005410	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIMB5_00005420	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB5_00005430	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIMB5_00005440	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB5_00005460	ENOG4107QIZ	NADH dehydrogenase
HIMB5_00005480	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HIMB5_00005490	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB5_00005500	ENOG4105DF2	NADH dehydrogenase subunit j
HIMB5_00005510	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB5_00005520	ENOG4105D65	subunit l
HIMB5_00005530	ENOG4105C8S	subunit m
HIMB5_00005540	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB5_00005560	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HIMB5_00005590	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HIMB5_00005600	ENOG4105D60	lipoprotein releasing system transmembrane protein
HIMB5_00005620	ENOG4105C0B	DNA polymerase III (alpha subunit)
HIMB5_00005630	ENOG4105CE9	30S ribosomal protein S2
HIMB5_00005640	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HIMB5_00005650	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HIMB5_00005660	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HIMB5_00005670	ENOG4105KNE	Phosphatidate cytidylyltransferase
HIMB5_00005680	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HIMB5_00005690	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HIMB5_00005700	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIMB5_00005720	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HIMB5_00005730	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB5_00005740	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB5_00005750	ENOG4105GYT	Protein of unknown function (DUF1009)
HIMB5_00005760	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB5_00005770	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HIMB5_00005780	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HIMB5_00005790	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HIMB5_00005800	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HIMB5_00005810	ENOG4105DDQ	anthranilate synthase
HIMB5_00005820	ENOG4105CRQ	synthase (Component I)
HIMB5_00005840	ENOG4105CP7	Triose-phosphate isomerase
HIMB5_00005860	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HIMB5_00005870	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HIMB5_00005880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HIMB5_00005900	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HIMB5_00005920	ENOG4105CEV	competence damage-inducible protein
HIMB5_00005940	ENOG4108EM8	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity)
HIMB5_00005950	ENOG4108HWS	Histidine kinase
HIMB5_00005960	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HIMB5_00005970	ENOG4105C1A	potassium transporter peripheral membrane
HIMB5_00006000	ENOG4107QXX	ABC transporter
HIMB5_00006010	ENOG4105EZ7	amino acid ABC transporter
HIMB5_00006020	ENOG4105DRP	amino acid AbC transporter
HIMB5_00006030	ENOG4105CDA	abc transporter atp-binding protein
HIMB5_00006040	ENOG4108WRK	Transcriptional regulator
HIMB5_00006070	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HIMB5_00006080	ENOG4105C01	Dihydroxy-acid dehydratase
HIMB5_00006090	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HIMB5_00006100	ENOG41080IJ	Diacylglycerol kinase
HIMB5_00006110	ENOG4105BZU	Histidine kinase
HIMB5_00006130	ENOG4105C8U	phosphate abc transporter
HIMB5_00006140	ENOG4105E2Z	phosphate ABC transporter (Permease
HIMB5_00006150	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HIMB5_00006160	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HIMB5_00006170	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HIMB5_00006200	ENOG4105FAV	ABC, transporter
HIMB5_00006210	ENOG4105FDK	ABC transporter
HIMB5_00006230	ENOG4105DG4	malate L-lactate dehydrogenase
HIMB5_00006260	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HIMB5_00006270	ENOG4105C75	arginyL-tRNA synthetase
HIMB5_00006290	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HIMB5_00006300	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HIMB5_00006310	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HIMB5_00006320	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HIMB5_00006330	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HIMB5_00006340	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HIMB5_00006350	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HIMB5_00006380	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HIMB5_00006400	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HIMB5_00006410	ENOG4108UUM	single-stranded DNA-binding protein
HIMB5_00006430	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HIMB5_00006440	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HIMB5_00006450	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HIMB5_00006490	ENOG4105CB5	ATP-dependent DNA helicase recG
HIMB5_00006520	ENOG4105FR1	rard protein
HIMB5_00006530	ENOG4105CVE	Lytic murein transglycosylase
HIMB5_00006550	ENOG4105DZ1	carboxypeptidase
HIMB5_00006560	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HIMB5_00006580	ENOG4107QRG	dna polymerase iii
HIMB5_00006590	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HIMB5_00006600	ENOG4105F8V	Hydrolase, tatD family
HIMB5_00006610	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HIMB5_00006620	ENOG4108V06	Glutathione peroxidase
HIMB5_00006630	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HIMB5_00006670	ENOG4108DQG	in Escherichia coli SbmA is involved in uptake of microcin J25
HIMB5_00006680	ENOG4105CBT	Fructose-1,6-bisphosphatase
HIMB5_00006710	ENOG4105VC4	domain protein
HIMB5_00006720	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HIMB5_00006800	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HIMB5_00006830	ENOG4105D6E	homoserine dehydrogenase
HIMB5_00006850	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HIMB5_00006860	ENOG4108UJD	30S ribosomal protein S9
HIMB5_00006870	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HIMB5_00006890	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HIMB5_00006930	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HIMB5_00006940	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HIMB5_00006950	ENOG41082R8	50S ribosomal protein l32
HIMB5_00006980	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HIMB5_00006990	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HIMB5_00007000	ENOG4107XZX	Involved in the transcription termination process (By similarity)
HIMB5_00007010	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HIMB5_00007020	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HIMB5_00007030	ENOG4108R6K	riboflavin synthase, subunit alpha
HIMB5_00007040	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HIMB5_00007050	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HIMB5_00007060	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HIMB5_00007070	ENOG4108YZG	isomerase
HIMB5_00007090	ENOG4105D52	delta-aminolevulinic acid dehydratase
HIMB5_00007100	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
HIMB5_00007110	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HIMB5_00007120	ENOG4105C3F	Signal peptidase i
HIMB5_00007130	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HIMB5_00007140	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HIMB5_00007150	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HIMB5_00007160	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HIMB5_00007170	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HIMB5_00007180	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HIMB5_00007190	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HIMB5_00007240	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB5_00007270	ENOG4105E5Q	amino acid AbC transporter
HIMB5_00007300	ENOG4105C72	UPF0176 protein
HIMB5_00007310	ENOG4108VQJ	O-methyltransferase
HIMB5_00007320	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HIMB5_00007330	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HIMB5_00007340	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HIMB5_00007350	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HIMB5_00007360	ENOG4105CXT	aspartate transcarbamylase
HIMB5_00007370	ENOG4105CD3	dihydroorotase
HIMB5_00007380	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HIMB5_00007400	ENOG4105KME	endoribonuclease L-psp
HIMB5_00007410	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HIMB5_00007430	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HIMB5_00007440	ENOG4105CJW	magnesium transporter
HIMB5_00007450	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HIMB5_00007470	ENOG4108ZT0	50S ribosomal protein l17
HIMB5_00007480	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB5_00007490	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HIMB5_00007500	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HIMB5_00007510	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HIMB5_00007530	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HIMB5_00007540	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HIMB5_00007550	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HIMB5_00007560	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HIMB5_00007570	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HIMB5_00007580	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HIMB5_00007590	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HIMB5_00007600	ENOG41087EN	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HIMB5_00007610	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HIMB5_00007620	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HIMB5_00007630	ENOG41067UQ	50s ribosomal protein l29
HIMB5_00007640	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HIMB5_00007650	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HIMB5_00007660	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HIMB5_00007670	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HIMB5_00007680	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HIMB5_00007690	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HIMB5_00007700	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HIMB5_00007710	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HIMB5_00007720	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HIMB5_00007730	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HIMB5_00007740	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HIMB5_00007750	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HIMB5_00007760	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB5_00007770	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB5_00007780	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HIMB5_00007790	ENOG4108VZM	50s ribosomal protein L10
HIMB5_00007800	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HIMB5_00007810	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HIMB5_00007820	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HIMB5_00007840	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HIMB5_00007870	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HIMB5_00007890	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HIMB5_00007910	ENOG4105DZG	Dehydrogenase
HIMB5_00007930	ENOG4105CEV	competence damage-inducible protein
HIMB5_00007940	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HIMB5_00007950	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HIMB5_00007960	ENOG4105C83	adenylosuccinate lyase
HIMB5_00007970	ENOG4107QPR	SAICAR synthetase
HIMB5_00007980	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
HIMB5_00007990	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HIMB5_00008000	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HIMB5_00008020	ENOG4105M2J	Glutaredoxin
HIMB5_00008030	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HIMB5_00008040	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HIMB5_00008050	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HIMB5_00008060	ENOG4105C8N	cysteinyl-tRNA synthetase
HIMB5_00008070	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HIMB5_00008080	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HIMB5_00008090	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HIMB5_00008100	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HIMB5_00008110	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HIMB5_00008120	ENOG4105DXD	2-methylcitrate dehydratase
HIMB5_00008130	ENOG4105CR4	methylisocitrate lyase
HIMB5_00008140	ENOG4105BZN	citrate synthase
HIMB5_00008160	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HIMB5_00008200	ENOG4105CKK	Glycosyl transferase, family 2
HIMB5_00008290	ENOG4106F1P	AAA ATPase, central domain protein
HIMB5_00008410	ENOG4108ZUW	Major pilin subunit
HIMB5_00008430	ENOG4107QHF	type ii secretion system protein e
HIMB5_00008440	ENOG4105E4G	Type IV pilus
HIMB5_00008470	ENOG4105CZX	twitching motility protein
HIMB5_00008510	ENOG4105E3A	(ABC) transporter
HIMB5_00008520	ENOG4105DA5	(ABC) transporter
HIMB5_00008580	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HIMB5_00008630	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HIMB5_00008730	ENOG4107R73	Mate efflux family protein
HIMB5_00008750	ENOG4107QPB	Beta-lactamase domain protein
HIMB5_00008810	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB5_00008840	ENOG410642W	LysR family Transcriptional regulator
HIMB5_00008850	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HIMB5_00008860	ENOG4105EUJ	GTP cyclohydrolase i
HIMB5_00008870	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HIMB5_00008890	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HIMB5_00008900	ENOG4105C10	Electron transfer flavoprotein
HIMB5_00008910	ENOG4105BZJ	Electron transfer flavoprotein
HIMB5_00008940	ENOG4105DYS	nad(p)h dehydrogenase (quinone)
HIMB5_00008980	ENOG4105K4P	CoA-binding domain protein
HIMB5_00008990	ENOG4105E39	Enoyl-CoA hydratase
HIMB5_00009000	ENOG4107WEA	mandelate racemase muconate lactonizing
HIMB5_00009020	ENOG4105MP9	class II Aldolase
HIMB5_00009090	ENOG4105DAE	Methylenetetrahydrofolate reductase
HIMB5_00009150	ENOG4108IGT	Dipeptidase
HIMB5_00009170	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HIMB5_00009180	ENOG4105CH7	arginosuccinase
HIMB5_00009230	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB5_00009250	ENOG4105DDR	sarcosine oxidase (Beta subunit)
HIMB5_00009260	ENOG4105CKU	formyltetrahydrofolate synthetase
HIMB5_00009280	ENOG4105F95	Monooxygenase
HIMB5_00009310	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
HIMB5_00009330	ENOG4108IJ9	(ABC) transporter
HIMB5_00009340	ENOG4108IJ9	(ABC) transporter
HIMB5_00009360	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HIMB5_00009370	ENOG4107U14	binding-protein-dependent transport systems inner membrane Component
HIMB5_00009380	ENOG4108IJ7	Glycine betaine
HIMB5_00009420	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB5_00009440	ENOG4105DDR	sarcosine oxidase (Beta subunit)
HIMB5_00009460	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HIMB5_00009480	ENOG4105CBC	glutamate synthase
HIMB5_00009530	ENOG4105EYU	Glutamine amido-transferase
HIMB5_00009540	ENOG4105M90	Glutamate synthase alpha subunit domain protein
HIMB5_00009550	ENOG4105CBC	glutamate synthase
HIMB5_00009560	ENOG4105C5F	glutamine synthetase
HIMB5_00009580	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HIMB5_00009600	ENOG4105D6Z	AFG1 family ATPase
HIMB5_00009640	ENOG4108I0Z	Aconitate hydratase
HIMB5_00009660	ENOG4108Z7R	Chaperone CsaA
HIMB5_00009670	ENOG4105CWC	Acetylornithine deacetylase
HIMB5_00009720	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HIMB5_00009730	ENOG4105D38	putrescine abc transporter
HIMB5_00009740	ENOG4105F38	ABC transporter, permease
HIMB5_00009760	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB5_00009830	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HIMB5_00009840	ENOG4108M8W	Monooxygenase
HIMB5_00009870	ENOG4105C26	Dehydrogenase
HIMB5_00009890	ENOG4105CP9	extracellular ligand-binding receptor
HIMB5_00009920	ENOG4108IV0	ABC, transporter
HIMB5_00009940	ENOG4105C0Z	ABC transporter
HIMB5_00009990	ENOG4108IV0	ABC, transporter
HIMB5_00010000	ENOG4105C0Z	ABC transporter
HIMB5_00010060	ENOG4105VW4	glutaredoxin 3
HIMB5_00010070	ENOG4105E0X	reductase
HIMB5_00010080	ENOG4105DGU	Histone deacetylase
HIMB5_00010090	ENOG4108JQ1	Dehydrogenase
HIMB5_00010120	ENOG4105CNI	cell division protein FtsW
HIMB5_00010130	ENOG4105CJN	penicillin-binding protein
HIMB5_00010150	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HIMB5_00010170	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HIMB5_00010220	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HIMB5_00010230	ENOG4108ZP8	Acetolactate synthase small subunit
HIMB5_00010240	ENOG4105C7K	acetolactate synthase
HIMB5_00010250	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HIMB5_00010280	ENOG4105EPW	hflc protein
HIMB5_00010290	ENOG4107QJR	hflk protein
HIMB5_00010300	ENOG4105D1F	ATP-binding protein
HIMB5_00010310	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
HIMB5_00010340	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HIMB5_00010350	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HIMB5_00010360	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HIMB5_00010380	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HIMB5_00010400	ENOG4105EAH	synthase
HIMB5_00010410	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HIMB5_00010420	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HIMB5_00010430	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HIMB5_00010440	ENOG4105CTB	Polyprenyl synthetase
HIMB5_00010460	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HIMB5_00010510	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HIMB5_00010520	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HIMB5_00010530	ENOG4105DWF	phosphomethylpyrimidine kinase
HIMB5_00010540	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HIMB5_00010600	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HIMB5_00010610	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HIMB5_00010630	ENOG4105M8F	Biopolymer transport protein exbD tolR
HIMB5_00010640	ENOG4105E02	MotA TolQ exbB proton channel
HIMB5_00010660	ENOG4105CDY	transcriptional regulatory protein
HIMB5_00010670	ENOG4105D48	metallophosphoesterase
HIMB5_00010680	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HIMB5_00010730	ENOG4105BZA	Phosphoglycerate kinase
HIMB5_00010740	ENOG4107R1Y	fructose-bisphosphate aldolase
HIMB5_00010750	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HIMB5_00010760	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HIMB5_00010770	ENOG4105ECY	inositol monophosphatase
HIMB5_00010780	ENOG41082FS	50S ribosomal protein L31
HIMB5_00010810	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HIMB5_00010820	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HIMB5_00010830	ENOG4105W8H	transhydrogenase (subunit alpha
HIMB5_00010840	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HIMB5_00010870	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HIMB5_00010880	ENOG4105C30	Nad-dependent epimerase dehydratase
HIMB5_00010890	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HIMB5_00010970	ENOG4105CG5	Glycosyl transferase (Group 1
HIMB5_00010990	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
HIMB5_00011000	ENOG4105CKK	Glycosyl transferase, family 2
HIMB5_00011070	ENOG4105C5E	polysaccharide biosynthesis protein
HIMB5_00011080	ENOG4105BZ1	(ABC) transporter
HIMB5_00011120	ENOG4105F0R	Cytidylyltransferase
HIMB5_00011130	ENOG4105K64	Glycosyl transferase, family 2
HIMB5_00011140	ENOG4105D9R	oxidoreductase
HIMB5_00011150	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HIMB5_00011180	ENOG4105CAQ	asparagine synthetase
HIMB5_00011210	ENOG4107R0V	Pyruvate dehydrogenase
HIMB5_00011220	ENOG4105D8V	Glucose sorbosone dehydrogenase
HIMB5_00011240	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HIMB5_00011260	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HIMB5_00011290	ENOG4105D2T	synthase
HIMB5_00011330	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HIMB5_00011390	ENOG4105DR5	peptidase
HIMB5_00011410	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HIMB5_00011420	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HIMB5_00011430	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HIMB5_00011440	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HIMB5_00011450	ENOG4105CFH	Aspartokinase
HIMB5_00011460	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HIMB5_00011480	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HIMB5_00011490	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HIMB5_00011500	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HIMB5_00011520	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HIMB5_00011530	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HIMB5_00011540	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HIMB5_00011560	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HIMB5_00011570	ENOG4105G9V	cytochrome C
HIMB5_00011580	ENOG4105DBV	ornithine carbamoyltransferase
HIMB5_00011590	ENOG4105C8Y	Acetylornithine aminotransferase
HIMB5_00011630	ENOG4105C2X	Arabinose 5-phosphate isomerase
HIMB5_00011650	ENOG4108IUZ	ABC transporter
HIMB5_00011660	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HIMB5_00011670	ENOG4105CAT	Cytidine monophosphate kinase
HIMB5_00011680	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HIMB5_00011690	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HIMB5_00011700	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HIMB5_00011710	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HIMB5_00011720	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HIMB5_00011730	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HIMB5_00011740	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HIMB5_00011750	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HIMB5_00011760	ENOG4105K63	Thioredoxin
HIMB5_00011820	ENOG4105CGY	Dna recombination protein
HIMB5_00011860	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
HIMB5_00011900	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB5_00011950	ENOG4105C3J	Cysteine desulfurase
HIMB5_00012200	ENOG4107RAN	Peptidase, M16
HIMB5_00012240	ENOG4105P5X	ATP phosphoribosyltransferase regulatory subunit
HIMB5_00012250	ENOG4105CUT	histidyl-tRNA synthetase
HIMB5_00012270	ENOG4105VEQ	Cold shock protein
HIMB5_00012290	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HIMB5_00012300	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HIMB5_00012320	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HIMB5_00012330	ENOG4105DHP	deoxycytidine triphosphate deaminase
HIMB5_00012390	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HIMB5_00012400	ENOG41082YK	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HIMB5_00012410	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HIMB5_00012420	ENOG4105CAS	nag kinase
HIMB5_00012440	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HIMB5_00012450	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HIMB5_00012480	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HIMB5_00012490	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HIMB5_00012500	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HIMB5_00012530	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HIMB5_00012540	ENOG4105D49	3-dehydroquinate synthase
HIMB5_00012590	ENOG4105TX3	Histidine kinase
HIMB5_00012600	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HIMB5_00012710	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HIMB5_00012720	ENOG4108ENN	phenylalanyl-tRNA synthetase (beta
HIMB5_00012730	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HIMB5_00012740	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HIMB5_00012750	ENOG41082BR	50S ribosomal protein L35
HIMB5_00012760	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HIMB5_00012770	ENOG4105C22	threonyL-tRNA synthetase
HIMB5_00012820	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HIMB5_00012830	ENOG4108TVT	permease
HIMB5_00012840	ENOG4107QSN	dihydrolipoamide acetyltransferase
HIMB5_00012850	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HIMB5_00012860	ENOG4105CHU	acetyl-coa acetyltransferase
HIMB5_00012910	ENOG4108Z4U	Ferredoxin
HIMB5_00012950	ENOG4108UM1	dedA family
HIMB5_00013020	ENOG4105CH7	arginosuccinase
HIMB5_00013040	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HIMB5_00013050	ENOG4105E9Q	Acyl-transferase
HIMB5_00013060	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HIMB5_00013070	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HIMB5_00013080	ENOG41087T6	Binds directly to 16S ribosomal RNA (By similarity)
HIMB5_00013090	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HIMB5_00013100	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HIMB5_00013110	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HIMB5_00013120	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HIMB5_00013130	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HIMB5_00013140	ENOG4105D06	uba thif-type nad fad binding protein
HIMB5_00013180	ENOG4108RAC	Rubrerythrin
HIMB5_00013200	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HIMB5_00013220	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HIMB5_00013260	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HIMB5_00013270	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HIMB5_00013280	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HIMB5_00013290	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HIMB5_00013310	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HIMB5_00013320	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HIMB5_00013330	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HIMB5_00013340	ENOG4105C9A	Phoh family
HIMB5_00013350	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HIMB5_00013360	ENOG41090R7	Ferric uptake
HIMB5_00013400	ENOG41083MR	nifu domain-containing protein
HIMB5_00013410	ENOG4105C31	Tryptophanyl-tRNA synthetase
HIMB5_00013430	ENOG4105C6K	Malic enzyme
HIMB5_00013440	ENOG4105W4M	Transport-associated protein
HIMB5_00013450	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HIMB5_00013470	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HIMB5_00013480	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HIMB5_00013490	ENOG4105CFG	Acts as a chaperone (By similarity)
HIMB5_00013500	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HIMB5_00013510	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HIMB5_00013520	ENOG4105CSM	endonuclease III
HIMB5_00013560	ENOG4105DFA	alanine racemase domain protein
HIMB5_00013600	ENOG4105C8T	Leucyl-tRNA synthetase
HIMB5_00013650	ENOG4107QJE	Chromosome Partitioning Protein
HIMB5_00013660	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
HIMB5_00013670	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HIMB5_00013680	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HIMB5_00013690	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HIMB5_00013700	ENOG4108YXA	Membrane
HIMB5_00013710	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HIMB5_00013720	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HIMB5_00013730	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HIMB5_00013740	ENOG4108UHJ	MAF-like protein
HIMB5_00013750	ENOG4105E2X	shikimate dehydrogenase
HIMB5_00013780	ENOG4107H8X	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HIMB5_00013820	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HIMB5_00013830	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HIMB5_00013840	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HIMB5_00013850	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HIMB5_00013860	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HIMB5_00013870	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HIMB5_00013880	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HIMB5_00013890	ENOG4105K59	histidine triad (HIT) protein
HIMB5_00013920	ENOG4105CNU	cell division protein FtsK
HIMB5_00013930	ENOG4105D0A	hydroxylase
HIMB5_00013940	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HIMB5_00013960	ENOG41090A4	Pterin carbinolamine dehydratase
HIMB5_00013970	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HIMB5_00013990	ENOG4105DJV	ribulose-phosphate 3-epimerase
HIMB5_00014010	ENOG4107QN1	sodium solute
HIMB5_00014040	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HIMB5_00014070	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HIMB5_00014080	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HIMB5_00014100	ENOG4105D64	Mechanosensitive ion channel
HIMB5_00014120	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HIMB5_00014170	ENOG4105CHR	reductase
HIMB5_00014180	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HIMB5_00014240	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HIMB5_00014280	ENOG4105CDH	Citrulline--aspartate ligase
HIMB5_00014300	ENOG4105CPC	Aldo Keto reductase
HIMB5_00014310	ENOG4105HFZ	Membrane
HIMB5_00014320	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HIMB5_00014330	ENOG4107835	probably involved in intracellular septation (By similarity)
HIMB5_00014350	ENOG41060IM	Heme exporter protein
HIMB5_00014370	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HIMB5_00014380	ENOG4105DA4	cytochrome c-type biogenesis protein
HIMB5_00014390	ENOG4107QX9	Thiol disulfide interChange protein
HIMB5_00014400	ENOG4105KWW	Biogenesis protein
HIMB5_00014420	ENOG4105DMF	Dehydrogenase
HIMB5_00014430	ENOG4105CHM	Aminotransferase
HIMB5_00014440	ENOG4105CQB	FAD linked oxidase domain protein
HIMB5_00014450	ENOG4105EU8	FAD linked oxidase domain protein
HIMB5_00014460	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HIMB5_00014480	ENOG4107QNK	)-transporter
HIMB5_00014500	ENOG4105E2A	Dehydrogenase
HIMB5_00014530	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HIMB5_00014540	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB5_00014550	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB5_00014590	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HIMB5_00014600	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HIMB5_00014620	ENOG4108PCN	EamA-like transporter family
HIMB5_00014650	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HIMB5_00014660	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIMB5_00014670	ENOG4105K5M	30s ribosomal protein S16