locus-tag	class	description
HIMB59_00000020	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HIMB59_00000030	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HIMB59_00000060	ENOG4105CJP	fad dependent oxidoreductase
HIMB59_00000070	ENOG4105CFQ	glutamine synthetase
HIMB59_00000080	ENOG4105D38	putrescine abc transporter
HIMB59_00000090	ENOG4105F38	ABC transporter, permease
HIMB59_00000100	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00000110	ENOG4108HM4	ABC transporter
HIMB59_00000130	ENOG4105DWY	Agmatine deiminase
HIMB59_00000170	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HIMB59_00000180	ENOG4105C9Q	fumarate hydratase class II
HIMB59_00000190	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB59_00000230	ENOG4105CPF	Cell wall formation (By similarity)
HIMB59_00000240	ENOG4105D4A	Cell wall formation (By similarity)
HIMB59_00000250	ENOG4105DFU	Cell wall formation (By similarity)
HIMB59_00000260	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HIMB59_00000280	ENOG4105C34	Pseudouridine synthase
HIMB59_00000290	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HIMB59_00000300	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HIMB59_00000320	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HIMB59_00000340	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HIMB59_00000360	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HIMB59_00000370	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HIMB59_00000390	ENOG4105SG9	biopolymer transport protein, ExbD
HIMB59_00000400	ENOG4105E02	MotA TolQ exbB proton channel
HIMB59_00000420	ENOG4105CDY	transcriptional regulatory protein
HIMB59_00000440	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HIMB59_00000470	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HIMB59_00000490	ENOG4105EIE	fructose-bisphosphate aldolase
HIMB59_00000500	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HIMB59_00000510	ENOG4105ECY	inositol monophosphatase
HIMB59_00000520	ENOG41082FS	50S ribosomal protein L31
HIMB59_00000550	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HIMB59_00000570	ENOG4105EWK	phytoene
HIMB59_00000580	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HIMB59_00000590	ENOG4105W0E	50S ribosomal protein L33
HIMB59_00000600	ENOG4105C72	UPF0176 protein
HIMB59_00000610	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HIMB59_00000630	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HIMB59_00000640	ENOG4105D52	delta-aminolevulinic acid dehydratase
HIMB59_00000650	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HIMB59_00000660	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HIMB59_00000670	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HIMB59_00000680	ENOG4108YXA	Membrane
HIMB59_00000700	ENOG4105E5Q	amino acid AbC transporter
HIMB59_00000780	ENOG4108IGT	Dipeptidase
HIMB59_00000840	ENOG4105CDA	abc transporter atp-binding protein
HIMB59_00000850	ENOG4105DRP	amino acid AbC transporter
HIMB59_00000860	ENOG4105EZ7	amino acid ABC transporter
HIMB59_00000870	ENOG4107QXX	ABC transporter
HIMB59_00000880	ENOG4108UJV	acyl-CoA thioesterase i
HIMB59_00000890	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HIMB59_00000910	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HIMB59_00000920	ENOG4105F87	Dehydratase
HIMB59_00000930	ENOG4105CKU	formyltetrahydrofolate synthetase
HIMB59_00000940	ENOG4105NWN	ApaG protein
HIMB59_00000950	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HIMB59_00000970	ENOG4105DBV	ornithine carbamoyltransferase
HIMB59_00000980	ENOG4105D64	Mechanosensitive ion channel
HIMB59_00000990	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HIMB59_00001000	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HIMB59_00001020	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
HIMB59_00001040	ENOG4107QIV	Cytochrome c biogenesis protein
HIMB59_00001050	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HIMB59_00001080	ENOG4107RDP	Dehydrogenase
HIMB59_00001090	ENOG4105M6F	mutator MutT protein
HIMB59_00001140	ENOG4105E0X	reductase
HIMB59_00001160	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HIMB59_00001210	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
HIMB59_00001220	ENOG4105C3Q	Glycosyl transferase, family 2
HIMB59_00001240	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HIMB59_00001250	ENOG4108DQG	in Escherichia coli SbmA is involved in uptake of microcin J25
HIMB59_00001270	ENOG4105D7W	serine acetyltransferase
HIMB59_00001300	ENOG4105DG4	malate L-lactate dehydrogenase
HIMB59_00001320	ENOG4108HQS	Glycine betaine
HIMB59_00001330	ENOG4108IJ7	Glycine betaine
HIMB59_00001350	ENOG4108IGT	Dipeptidase
HIMB59_00001390	ENOG4107TNW	(Aminomethyl transferase) family protein
HIMB59_00001440	ENOG4108V06	Glutathione peroxidase
HIMB59_00001450	ENOG4105KVH	Transcriptional regulator
HIMB59_00001460	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HIMB59_00001490	ENOG4108YZA	Nitrogen regulatory protein pii
HIMB59_00001500	ENOG4107TNW	(Aminomethyl transferase) family protein
HIMB59_00001570	ENOG4105E3A	(ABC) transporter
HIMB59_00001580	ENOG4105DA5	(ABC) transporter
HIMB59_00001600	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HIMB59_00001620	ENOG4107QUV	Domain protein
HIMB59_00001630	ENOG4105CEV	competence damage-inducible protein
HIMB59_00001640	ENOG4105CEY	Amp-dependent synthetase and ligase
HIMB59_00001650	ENOG41060WC	Enoyl-CoA hydratase
HIMB59_00001670	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HIMB59_00001690	ENOG4108JQ7	(ABC) transporter
HIMB59_00001710	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00001720	ENOG4105DEF	Extracellular solute-binding protein, family 5
HIMB59_00001760	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HIMB59_00001770	ENOG4107XKF	NMT1 THI5 Like Domain Protein
HIMB59_00001780	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00001790	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00001800	ENOG4107QKW	extracellular solute-binding protein family 1
HIMB59_00001820	ENOG4105FDK	ABC transporter
HIMB59_00001830	ENOG4105FAV	ABC, transporter
HIMB59_00001850	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HIMB59_00001860	ENOG4105K46	50S ribosomal protein l27
HIMB59_00001870	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HIMB59_00001880	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HIMB59_00001910	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HIMB59_00001930	ENOG4105CN1	protease
HIMB59_00001940	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HIMB59_00001950	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HIMB59_00001960	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HIMB59_00001970	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HIMB59_00001980	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HIMB59_00001990	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HIMB59_00002010	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HIMB59_00002020	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HIMB59_00002030	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HIMB59_00002130	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HIMB59_00002140	ENOG4105VG0	50S ribosomal protein l34
HIMB59_00002150	ENOG41086GJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HIMB59_00002160	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HIMB59_00002170	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HIMB59_00002180	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HIMB59_00002200	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HIMB59_00002210	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HIMB59_00002240	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HIMB59_00002250	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HIMB59_00002260	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HIMB59_00002280	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HIMB59_00002290	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HIMB59_00002300	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HIMB59_00002310	ENOG4105CQC	Prephenate dehydratase
HIMB59_00002330	ENOG4105G9V	cytochrome C
HIMB59_00002340	ENOG4105EYM	Major Facilitator superfamily
HIMB59_00002360	ENOG4107RN3	metallophosphoesterase
HIMB59_00002440	ENOG4108MDK	Dehydrogenase
HIMB59_00002450	ENOG4105CMG	Carbohydrate kinase
HIMB59_00002460	ENOG4105EMU	Dehydrogenase
HIMB59_00002470	ENOG4107VUR	extracellular solute-binding protein
HIMB59_00002500	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HIMB59_00002510	ENOG4105MVE	transcriptional regulator
HIMB59_00002520	ENOG4108YZG	isomerase
HIMB59_00002530	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HIMB59_00002540	ENOG4105CHR	reductase
HIMB59_00002560	ENOG4107S5T	Carbohydrate kinase
HIMB59_00002580	ENOG4107W7X	Aldolase
HIMB59_00002590	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HIMB59_00002600	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HIMB59_00002610	ENOG4105F04	LysR family Transcriptional regulator
HIMB59_00002620	ENOG4108I0Z	Aconitate hydratase
HIMB59_00002630	ENOG4105C7S	Dehydrogenase
HIMB59_00002640	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HIMB59_00002700	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HIMB59_00002720	ENOG4105CH5	extracellular solute-binding protein, family 7
HIMB59_00002740	ENOG4105CHU	acetyl-coa acetyltransferase
HIMB59_00002750	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HIMB59_00002760	ENOG4107YD3	Thioesterase
HIMB59_00002770	ENOG4108IAJ	Nad-dependent epimerase dehydratase
HIMB59_00002800	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
HIMB59_00002830	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HIMB59_00002840	ENOG4108ZNX	Heat shock protein
HIMB59_00002880	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HIMB59_00002890	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HIMB59_00002900	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HIMB59_00002910	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HIMB59_00002920	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HIMB59_00002930	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HIMB59_00002940	ENOG4105K5M	30s ribosomal protein S16
HIMB59_00002950	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIMB59_00002960	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HIMB59_00002970	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HIMB59_00002990	ENOG4107835	probably involved in intracellular septation (By similarity)
HIMB59_00003000	ENOG4105BZA	Phosphoglycerate kinase
HIMB59_00003060	ENOG41082R8	50S ribosomal protein l32
HIMB59_00003080	ENOG4108VJ1	Transcriptional regulator (CarD family
HIMB59_00003090	ENOG4108Z4U	Ferredoxin
HIMB59_00003130	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00003150	ENOG41060IM	Heme exporter protein
HIMB59_00003160	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HIMB59_00003170	ENOG4105DA4	cytochrome c-type biogenesis protein
HIMB59_00003180	ENOG4107QX9	Thiol disulfide interChange protein
HIMB59_00003190	ENOG4105KWW	Biogenesis protein
HIMB59_00003210	ENOG4105DSP	amino acid AbC transporter
HIMB59_00003230	ENOG4106PMH	Extracellular solute-binding protein family 3
HIMB59_00003240	ENOG4108JEH	abc transporter atp-binding protein
HIMB59_00003250	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HIMB59_00003270	ENOG4105CDH	Citrulline--aspartate ligase
HIMB59_00003290	ENOG4105K6V	RNA polymerase
HIMB59_00003320	ENOG4105KZX	Pterin carbinolamine dehydratase
HIMB59_00003330	ENOG4105CPC	Aldo Keto reductase
HIMB59_00003340	ENOG4105HFZ	Membrane
HIMB59_00003390	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HIMB59_00003410	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HIMB59_00003420	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HIMB59_00003430	ENOG4105DJV	ribulose-phosphate 3-epimerase
HIMB59_00003440	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HIMB59_00003500	ENOG4108NIW	Leucine export protein LeuE
HIMB59_00003560	ENOG4107QR8	Thioredoxin
HIMB59_00003570	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HIMB59_00003580	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HIMB59_00003590	ENOG4105CNU	cell division protein FtsK
HIMB59_00003620	ENOG4105DFA	alanine racemase domain protein
HIMB59_00003640	ENOG4107RDJ	Sulfotransferase
HIMB59_00003670	ENOG4105C8T	Leucyl-tRNA synthetase
HIMB59_00003700	ENOG4105FA0	parb-like partition protein
HIMB59_00003710	ENOG4107QJE	Chromosome Partitioning Protein
HIMB59_00003730	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HIMB59_00003740	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HIMB59_00003760	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HIMB59_00003770	ENOG4108UHJ	MAF-like protein
HIMB59_00003780	ENOG4105E2X	shikimate dehydrogenase
HIMB59_00003790	ENOG4107V86	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HIMB59_00003830	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HIMB59_00003840	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HIMB59_00003850	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HIMB59_00003860	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HIMB59_00003870	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HIMB59_00003880	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HIMB59_00003890	ENOG4105K59	histidine triad (HIT) protein
HIMB59_00003910	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HIMB59_00003930	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HIMB59_00003940	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HIMB59_00003950	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HIMB59_00003980	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HIMB59_00003990	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HIMB59_00004050	ENOG4105C28	cystathionine
HIMB59_00004060	ENOG4105C6T	cysteine synthase
HIMB59_00004100	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00004120	ENOG4105CHF	Glutathione S-transferase
HIMB59_00004130	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HIMB59_00004140	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HIMB59_00004150	ENOG41087NI	Sulfite exporter TauE/SafE
HIMB59_00004170	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HIMB59_00004200	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HIMB59_00004210	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HIMB59_00004300	ENOG4105CTB	Polyprenyl synthetase
HIMB59_00004350	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
HIMB59_00004370	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HIMB59_00004400	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HIMB59_00004410	ENOG41083MR	nifu domain-containing protein
HIMB59_00004420	ENOG4105C31	Tryptophanyl-tRNA synthetase
HIMB59_00004440	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HIMB59_00004460	ENOG4105CJ3	phosphate transporter
HIMB59_00004490	ENOG4107QMZ	Dehydrogenase
HIMB59_00004520	ENOG4105C4Y	ABC transporter
HIMB59_00004540	ENOG4105E0C	molybdate abc transporter
HIMB59_00004550	ENOG4105BZU	Histidine kinase
HIMB59_00004570	ENOG4105C8U	phosphate abc transporter
HIMB59_00004590	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00004600	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HIMB59_00004610	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HIMB59_00004620	ENOG4108UXE	Protein tyrosine phosphatase
HIMB59_00004640	ENOG41080IJ	Diacylglycerol kinase
HIMB59_00004680	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HIMB59_00004690	ENOG4108Z1Z	gCN5-related N-acetyltransferase
HIMB59_00004700	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HIMB59_00004710	ENOG4105C9A	Phoh family
HIMB59_00004730	ENOG4108JU5	Magnesium and cobalt efflux protein
HIMB59_00004740	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HIMB59_00004750	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HIMB59_00004760	ENOG4105CHV	Transcription elongation factor NusA
HIMB59_00004770	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HIMB59_00004780	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HIMB59_00004790	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HIMB59_00004810	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HIMB59_00004820	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HIMB59_00004840	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HIMB59_00004850	ENOG4105CUZ	uba thif-type nad fad binding protein
HIMB59_00004860	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HIMB59_00004870	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HIMB59_00004880	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HIMB59_00004890	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HIMB59_00004900	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HIMB59_00004910	ENOG4108317	Binds directly to 16S ribosomal RNA (By similarity)
HIMB59_00004930	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HIMB59_00004940	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HIMB59_00004960	ENOG4105TX3	Histidine kinase
HIMB59_00004970	ENOG4108UYB	regulatoR
HIMB59_00004980	ENOG4105C2M	dna polymerase I
HIMB59_00005020	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HIMB59_00005040	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HIMB59_00005050	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HIMB59_00005110	ENOG4105H1N	peptidase, M24
HIMB59_00005150	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HIMB59_00005160	ENOG4105C26	Dehydrogenase
HIMB59_00005170	ENOG4105ECM	Sensor protein basS pmrB
HIMB59_00005200	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00005210	ENOG4108IY8	ABC, transporter
HIMB59_00005220	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00005230	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HIMB59_00005240	ENOG4105CEY	Amp-dependent synthetase and ligase
HIMB59_00005320	ENOG4105CAY	ferredoxin--nadp reductase
HIMB59_00005350	ENOG4105E2A	Dehydrogenase
HIMB59_00005380	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HIMB59_00005390	ENOG4108IJ9	(ABC) transporter
HIMB59_00005400	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00005410	ENOG4105D8V	Glucose sorbosone dehydrogenase
HIMB59_00005420	ENOG4105CMR	udp-glucose 4-epimerase
HIMB59_00005430	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HIMB59_00005440	ENOG4108JQ1	Dehydrogenase
HIMB59_00005450	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HIMB59_00005480	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00005500	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
HIMB59_00005510	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00005520	ENOG4105EPJ	extracellular solute-binding protein family 1
HIMB59_00005540	ENOG4108JJ7	ABC transporter
HIMB59_00005560	ENOG4105VPX	protein, conserved in bacteria
HIMB59_00005600	ENOG4108HW3	(ABC) transporter
HIMB59_00005660	ENOG4105DEI	Mannitol dehydrogenase
HIMB59_00005670	ENOG4105CHR	reductase
HIMB59_00005680	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00005720	ENOG4105ETE	Transcriptional regulator (LacI family
HIMB59_00005760	ENOG4105DGU	Histone deacetylase
HIMB59_00005800	ENOG4105CEY	Amp-dependent synthetase and ligase
HIMB59_00005820	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HIMB59_00005830	ENOG4107R7A	Allophanate hydrolase subunit 2
HIMB59_00005840	ENOG4105P4J	Allophanate hydrolase, subunit 1
HIMB59_00005850	ENOG4105E7W	lamb ycsf family protein
HIMB59_00005910	ENOG4105CYM	Glutathione S-transferase
HIMB59_00005950	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HIMB59_00005960	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HIMB59_00005970	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HIMB59_00005980	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HIMB59_00005990	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HIMB59_00006000	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HIMB59_00006010	ENOG41083IJ	DNA-binding protein
HIMB59_00006020	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HIMB59_00006030	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HIMB59_00006040	ENOG4108IUZ	ABC transporter
HIMB59_00006070	ENOG4105C2X	Arabinose 5-phosphate isomerase
HIMB59_00006100	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HIMB59_00006130	ENOG4105DWV	Homoserine O-trans-acetylase
HIMB59_00006170	ENOG41082BR	50S ribosomal protein L35
HIMB59_00006180	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HIMB59_00006190	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HIMB59_00006200	ENOG4108ENN	phenylalanyl-tRNA synthetase (beta
HIMB59_00006210	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HIMB59_00006280	ENOG4105CGY	Dna recombination protein
HIMB59_00006350	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB59_00006400	ENOG4105DKQ	ROK family
HIMB59_00006430	ENOG4105CPC	Aldo Keto reductase
HIMB59_00006440	ENOG4108RVA	ribokinase
HIMB59_00006450	ENOG4105NWF	RbsD or FucU transport
HIMB59_00006500	ENOG4105CMG	Carbohydrate kinase
HIMB59_00006510	ENOG4107Z1W	Fructose transport system kinase
HIMB59_00006520	ENOG4105C2J	ABC transporter
HIMB59_00006530	ENOG4105CNN	ABC, transporter
HIMB59_00006540	ENOG4107R5G	Periplasmic binding protein LacI transcriptional regulator
HIMB59_00006550	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HIMB59_00006560	ENOG4108IUS	Transketolase
HIMB59_00006570	ENOG4108HHA	Transketolase
HIMB59_00006590	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HIMB59_00006600	ENOG4107RNG	ABC transporter
HIMB59_00006610	ENOG4105C2J	ABC transporter
HIMB59_00006620	ENOG4105CNV	Aldolase
HIMB59_00006650	ENOG4105CHR	reductase
HIMB59_00006680	ENOG4105C2J	ABC transporter
HIMB59_00006690	ENOG4105CNN	ABC, transporter
HIMB59_00006700	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
HIMB59_00006710	ENOG4105CHR	reductase
HIMB59_00006720	ENOG4105H1N	peptidase, M24
HIMB59_00006730	ENOG4107RUY	(E1 component), alpha subunit
HIMB59_00006750	ENOG4105C7S	Dehydrogenase
HIMB59_00006760	ENOG4105C26	Dehydrogenase
HIMB59_00006770	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HIMB59_00006800	ENOG4105D2N	Aldolase
HIMB59_00006810	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HIMB59_00006850	ENOG4105CJ1	ABC, transporter
HIMB59_00006860	ENOG4105C93	Xylose Isomerase
HIMB59_00006930	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00006950	ENOG4108IJ9	(ABC) transporter
HIMB59_00006960	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00006980	ENOG4105CMT	Dihydroxyacetone kinase
HIMB59_00007020	ENOG4105C72	UPF0176 protein
HIMB59_00007080	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HIMB59_00007100	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HIMB59_00007150	ENOG4105DWV	Homoserine O-trans-acetylase
HIMB59_00007160	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HIMB59_00007200	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HIMB59_00007220	ENOG4105CH7	arginosuccinase
HIMB59_00007280	ENOG4108UM1	dedA family
HIMB59_00007300	ENOG4105KST	dependent repressor
HIMB59_00007310	ENOG4105F38	ABC transporter, permease
HIMB59_00007350	ENOG4105DTN	riboflavin biosynthesis protein ribF
HIMB59_00007360	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HIMB59_00007370	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HIMB59_00007390	ENOG4105C89	phosphohexose isomerase
HIMB59_00007410	ENOG4105FE9	pseudouridine synthase
HIMB59_00007420	ENOG4108Z86	Glutamine amidotransferase
HIMB59_00007430	ENOG4107Y2X	deaminase
HIMB59_00007470	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HIMB59_00007480	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HIMB59_00007490	ENOG4105KB8	(LipO)protein
HIMB59_00007500	ENOG4105BZ1	(ABC) transporter
HIMB59_00007530	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HIMB59_00007550	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HIMB59_00007560	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HIMB59_00007570	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HIMB59_00007590	ENOG4105CTD	carboxy-peptidase
HIMB59_00007600	ENOG4105D98	threonine synthase
HIMB59_00007630	ENOG4105CUV	Homoserine Kinase
HIMB59_00007660	ENOG4108VHN	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HIMB59_00007670	ENOG4107Q7J	ATP synthase subunit C
HIMB59_00007680	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HIMB59_00007700	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HIMB59_00007730	ENOG4105CEN	a g-specific adenine glycosylase
HIMB59_00007740	ENOG4105CEC	DNA methylase N-4 N-6
HIMB59_00007750	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HIMB59_00007760	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HIMB59_00007770	ENOG4107SC1	transglycosylase
HIMB59_00007820	ENOG4105C5H	ABC transporter
HIMB59_00007830	ENOG4105DJ0	Poly(A) Polymerase
HIMB59_00007840	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HIMB59_00007850	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HIMB59_00007860	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HIMB59_00007870	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HIMB59_00007880	ENOG4105C3G	gtp-binding protein
HIMB59_00007890	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HIMB59_00007900	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HIMB59_00007910	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HIMB59_00007940	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HIMB59_00007980	ENOG4108Z7R	Chaperone CsaA
HIMB59_00007990	ENOG4105E0F	Histidine kinase
HIMB59_00008020	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HIMB59_00008060	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HIMB59_00008070	ENOG4105DCF	alanine dehydrogenase
HIMB59_00008080	ENOG4105CNG	UPF0061 protein
HIMB59_00008090	ENOG410642W	LysR family Transcriptional regulator
HIMB59_00008110	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HIMB59_00008120	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HIMB59_00008150	ENOG4105D7Z	glutathione synthase
HIMB59_00008180	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HIMB59_00008190	ENOG4105CHM	Aminotransferase
HIMB59_00008230	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HIMB59_00008240	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HIMB59_00008250	ENOG4105W8H	transhydrogenase (subunit alpha
HIMB59_00008260	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HIMB59_00008300	ENOG4105C8Y	Acetylornithine aminotransferase
HIMB59_00008320	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HIMB59_00008340	ENOG4105C5F	glutamine synthetase
HIMB59_00008350	ENOG4105C0A	alcohol dehydrogenase
HIMB59_00008380	ENOG4105C09	Bile acid
HIMB59_00008390	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HIMB59_00008460	ENOG4105W39	Membrane
HIMB59_00008480	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HIMB59_00008500	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HIMB59_00008510	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HIMB59_00008530	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HIMB59_00008610	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
HIMB59_00008620	ENOG4105D1F	ATP-binding protein
HIMB59_00008630	ENOG4107QJR	hflk protein
HIMB59_00008640	ENOG4105EPW	hflc protein
HIMB59_00008660	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HIMB59_00008670	ENOG4105C7K	acetolactate synthase
HIMB59_00008680	ENOG4108ZP8	Acetolactate synthase small subunit
HIMB59_00008690	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HIMB59_00008700	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HIMB59_00008740	ENOG4105CJN	penicillin-binding protein
HIMB59_00008750	ENOG4105CNI	cell division protein FtsW
HIMB59_00008780	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HIMB59_00008790	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HIMB59_00008800	ENOG4105EAH	synthase
HIMB59_00008810	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HIMB59_00008830	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HIMB59_00008870	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HIMB59_00008880	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HIMB59_00008890	ENOG4108W6C	Dehydrogenase
HIMB59_00008900	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HIMB59_00008920	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HIMB59_00008930	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HIMB59_00008940	ENOG4107Z7P	Ferredoxin
HIMB59_00008950	ENOG4105DK7	lysyl-tRNA synthetase
HIMB59_00008960	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HIMB59_00008980	ENOG4105KDC	50s ribosomal protein l28
HIMB59_00009000	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HIMB59_00009050	ENOG4108JU6	CBS domain protein
HIMB59_00009060	ENOG4105D49	3-dehydroquinate synthase
HIMB59_00009070	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HIMB59_00009110	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HIMB59_00009120	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HIMB59_00009130	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HIMB59_00009180	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HIMB59_00009190	ENOG4105CFH	Aspartokinase
HIMB59_00009210	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HIMB59_00009220	ENOG4105CUT	histidyl-tRNA synthetase
HIMB59_00009230	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HIMB59_00009240	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HIMB59_00009260	ENOG4105DR5	peptidase
HIMB59_00009290	ENOG4105CP9	extracellular ligand-binding receptor
HIMB59_00009310	ENOG4108IV0	ABC, transporter
HIMB59_00009320	ENOG4105C0Z	ABC transporter
HIMB59_00009330	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HIMB59_00009340	ENOG4105C32	Amino acid ABC transporter (Permease)
HIMB59_00009360	ENOG4105CJR	Integral membrane protein (MviN
HIMB59_00009400	ENOG4106VK6	Flagellar motor protein
HIMB59_00009420	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HIMB59_00009430	ENOG4105YK5	50S ribosomal protein L36
HIMB59_00009440	ENOG4105C3M	thioredoxin reductase
HIMB59_00009470	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HIMB59_00009480	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HIMB59_00009490	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HIMB59_00009510	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HIMB59_00009520	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HIMB59_00009570	ENOG4105C4R	Atp-dependent dna helicase
HIMB59_00009580	ENOG4105DC7	peptidase M24
HIMB59_00009590	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HIMB59_00009600	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HIMB59_00009620	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HIMB59_00009640	ENOG4108V6E	Cell division protein mraZ
HIMB59_00009670	ENOG4107RF6	penicillin-binding protein
HIMB59_00009680	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HIMB59_00009690	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HIMB59_00009700	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HIMB59_00009710	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HIMB59_00009720	ENOG4105CNI	cell division protein FtsW
HIMB59_00009730	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HIMB59_00009750	ENOG41086K9	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HIMB59_00009760	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HIMB59_00009770	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HIMB59_00009780	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HIMB59_00009790	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HIMB59_00009810	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HIMB59_00009840	ENOG4107TSN	permease
HIMB59_00009870	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HIMB59_00009890	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HIMB59_00009900	ENOG4105VFE	sira family
HIMB59_00009910	ENOG4105C5Q	Transcriptional regulator
HIMB59_00009930	ENOG4108IEG	Formate dehydrogenase Alpha subunit
HIMB59_00009960	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HIMB59_00009990	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HIMB59_00010010	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HIMB59_00010020	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HIMB59_00010030	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HIMB59_00010040	ENOG4108VZM	50s ribosomal protein L10
HIMB59_00010050	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HIMB59_00010060	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB59_00010070	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB59_00010080	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HIMB59_00010090	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HIMB59_00010100	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HIMB59_00010110	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HIMB59_00010120	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HIMB59_00010130	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HIMB59_00010140	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HIMB59_00010150	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HIMB59_00010160	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HIMB59_00010170	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HIMB59_00010180	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HIMB59_00010190	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HIMB59_00010210	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HIMB59_00010220	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HIMB59_00010240	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HIMB59_00010250	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HIMB59_00010260	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HIMB59_00010270	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HIMB59_00010280	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HIMB59_00010290	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HIMB59_00010310	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HIMB59_00010320	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HIMB59_00010330	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HIMB59_00010340	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HIMB59_00010350	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HIMB59_00010360	ENOG4108ZT0	50S ribosomal protein l17
HIMB59_00010370	ENOG4105WMR	Protein CrcB homolog
HIMB59_00010380	ENOG4105EI2	Pseudouridine synthase
HIMB59_00010390	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HIMB59_00010410	ENOG4105CJW	magnesium transporter
HIMB59_00010430	ENOG4105DZ1	carboxypeptidase
HIMB59_00010480	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HIMB59_00010490	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HIMB59_00010520	ENOG4107QQB	Ribonuclease E
HIMB59_00010530	ENOG4108JQC	penicillin-binding protein 1A
HIMB59_00010540	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HIMB59_00010580	ENOG4105KT5	UmuD protein
HIMB59_00010600	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HIMB59_00010650	ENOG4107XM9	(LipO)protein
HIMB59_00010660	ENOG4108IQE	Amp-dependent synthetase and ligase
HIMB59_00010690	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HIMB59_00010750	ENOG4105CFQ	glutamine synthetase
HIMB59_00010760	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HIMB59_00010810	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HIMB59_00010820	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HIMB59_00010830	ENOG4105C01	Dihydroxy-acid dehydratase
HIMB59_00010840	ENOG4105CGK	Exodeoxyribonuclease III
HIMB59_00010850	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HIMB59_00010860	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HIMB59_00010870	ENOG4105C75	arginyL-tRNA synthetase
HIMB59_00010880	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
HIMB59_00010890	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HIMB59_00010900	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HIMB59_00010910	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00010920	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HIMB59_00010940	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HIMB59_00010950	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HIMB59_00010980	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HIMB59_00010990	ENOG4107WHF	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HIMB59_00011010	ENOG4108UUM	single-stranded DNA-binding protein
HIMB59_00011030	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HIMB59_00011050	ENOG4108V0E	nucleoside 2-deoxyribosyltransferase YtoQ
HIMB59_00011060	ENOG4107SET	aldo keto reductase
HIMB59_00011070	ENOG4108VW9	Membrane
HIMB59_00011080	ENOG4105DC7	peptidase M24
HIMB59_00011100	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00011110	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00011120	ENOG4108JQ6	ABC transporter
HIMB59_00011140	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HIMB59_00011190	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HIMB59_00011200	ENOG4105E2X	shikimate dehydrogenase
HIMB59_00011240	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HIMB59_00011320	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00011330	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HIMB59_00011340	ENOG4107TYH	extracellular solute-binding protein family 1
HIMB59_00011350	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HIMB59_00011360	ENOG4105D81	ABC transporter, permease
HIMB59_00011370	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
HIMB59_00011380	ENOG4105C26	Dehydrogenase
HIMB59_00011390	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HIMB59_00011410	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HIMB59_00011420	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
HIMB59_00011480	ENOG4105CB5	ATP-dependent DNA helicase recG
HIMB59_00011490	ENOG4108JA2	transcriptioN-repair coupling factor
HIMB59_00011550	ENOG4105CVE	Lytic murein transglycosylase
HIMB59_00011570	ENOG4105DZ1	carboxypeptidase
HIMB59_00011580	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HIMB59_00011590	ENOG4107QRG	dna polymerase iii
HIMB59_00011610	ENOG4105F8V	Hydrolase, tatD family
HIMB59_00011620	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HIMB59_00011630	ENOG4108UIN	ybak prolyl-trna synthetase associated region
HIMB59_00011650	ENOG4105CI3	gtp-binding protein typa
HIMB59_00011660	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HIMB59_00011670	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HIMB59_00011680	ENOG4105F0I	Aminotransferase
HIMB59_00011690	ENOG4105F0I	Aminotransferase
HIMB59_00011720	ENOG4108RAV	Conserved protein
HIMB59_00011750	ENOG4108VPT	UPF0234 protein
HIMB59_00011790	ENOG4105DC8	reductase
HIMB59_00011810	ENOG4105DXN	mazG family
HIMB59_00011840	ENOG4105C8Y	Acetylornithine aminotransferase
HIMB59_00011850	ENOG4105CAS	nag kinase
HIMB59_00011880	ENOG4105CHM	Aminotransferase
HIMB59_00011890	ENOG4105CBX	hi0933 family
HIMB59_00011910	ENOG4105NBK	UPF0345 protein
HIMB59_00011930	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HIMB59_00011940	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HIMB59_00011960	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HIMB59_00012000	ENOG4105C0Z	ABC transporter
HIMB59_00012010	ENOG4108IV0	ABC, transporter
HIMB59_00012130	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HIMB59_00012160	ENOG4105CNN	ABC, transporter
HIMB59_00012170	ENOG4108JQ9	ABC transporter
HIMB59_00012190	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HIMB59_00012200	ENOG4105ECY	inositol monophosphatase
HIMB59_00012210	ENOG4105C1A	potassium transporter peripheral membrane
HIMB59_00012220	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HIMB59_00012230	ENOG4105ES5	Histidine kinase
HIMB59_00012240	ENOG4108EM8	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity)
HIMB59_00012250	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HIMB59_00012260	ENOG4107QN2	dihydrolipoyl dehydrogenase
HIMB59_00012270	ENOG4105C7S	Dehydrogenase
HIMB59_00012280	ENOG4105CPP	Dehydrogenase, E1 component
HIMB59_00012290	ENOG4107R0V	Pyruvate dehydrogenase
HIMB59_00012320	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HIMB59_00012330	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HIMB59_00012340	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HIMB59_00012360	ENOG4105CP7	Triose-phosphate isomerase
HIMB59_00012380	ENOG4105CRQ	synthase (Component I)
HIMB59_00012390	ENOG4105DDQ	anthranilate synthase
HIMB59_00012400	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HIMB59_00012410	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HIMB59_00012440	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HIMB59_00012450	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HIMB59_00012460	ENOG4105BZN	citrate synthase
HIMB59_00012470	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB59_00012490	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB59_00012500	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HIMB59_00012510	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HIMB59_00012520	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIMB59_00012560	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HIMB59_00012570	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HIMB59_00012580	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HIMB59_00012590	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HIMB59_00012600	ENOG4105CE9	30S ribosomal protein S2
HIMB59_00012610	ENOG4105C0B	DNA polymerase III (alpha subunit)
HIMB59_00012620	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HIMB59_00012670	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HIMB59_00012690	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB59_00012700	ENOG4105C8S	subunit m
HIMB59_00012710	ENOG4105D65	subunit l
HIMB59_00012720	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB59_00012730	ENOG4105DF2	NADH dehydrogenase subunit j
HIMB59_00012740	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB59_00012750	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HIMB59_00012770	ENOG4107QIZ	NADH dehydrogenase
HIMB59_00012790	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB59_00012800	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIMB59_00012810	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HIMB59_00012820	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIMB59_00012860	ENOG4105K70	DNA-binding protein
HIMB59_00012870	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HIMB59_00012890	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HIMB59_00012900	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HIMB59_00012930	ENOG4108YZA	Nitrogen regulatory protein pii
HIMB59_00012940	ENOG4105C5F	glutamine synthetase
HIMB59_00012950	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HIMB59_00012960	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HIMB59_00012970	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HIMB59_00012980	ENOG4105C22	threonyL-tRNA synthetase
HIMB59_00013010	ENOG4108Z4V	iron-sulfur cluster assembly
HIMB59_00013020	ENOG4105VG1	fes assembly suf system protein
HIMB59_00013030	ENOG4105C9B	Cysteine desulfurase
HIMB59_00013040	ENOG4105JRK	feS assembly protein SufD
HIMB59_00013050	ENOG4105C3K	feS assembly ATPase SufC
HIMB59_00013070	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HIMB59_00013080	ENOG4105DHZ	alpha beta
HIMB59_00013090	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HIMB59_00013100	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HIMB59_00013110	ENOG4105DWV	Homoserine O-trans-acetylase
HIMB59_00013120	ENOG4105C5F	glutamine synthetase
HIMB59_00013140	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HIMB59_00013170	ENOG4105C5F	glutamine synthetase
HIMB59_00013200	ENOG4105CBC	glutamate synthase
HIMB59_00013220	ENOG4105EYU	Glutamine amido-transferase
HIMB59_00013240	ENOG4105DDR	sarcosine oxidase (Beta subunit)
HIMB59_00013270	ENOG4105CBC	glutamate synthase
HIMB59_00013280	ENOG4105M90	Glutamate synthase alpha subunit domain protein
HIMB59_00013290	ENOG4105EYU	Glutamine amido-transferase
HIMB59_00013310	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB59_00013330	ENOG4105DDR	sarcosine oxidase (Beta subunit)
HIMB59_00013340	ENOG4105F95	Monooxygenase
HIMB59_00013350	ENOG4105DVW	rieske (2Fe-2S)
HIMB59_00013360	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB59_00013390	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HIMB59_00013410	ENOG4107U14	binding-protein-dependent transport systems inner membrane Component
HIMB59_00013420	ENOG4108IJ7	Glycine betaine
HIMB59_00013440	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HIMB59_00013450	ENOG4105CSU	acyl-Coa dehydrogenase
HIMB59_00013460	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HIMB59_00013470	ENOG4105C10	Electron transfer flavoprotein
HIMB59_00013480	ENOG4105BZJ	Electron transfer flavoprotein
HIMB59_00013510	ENOG4108KN0	Choline kinase
HIMB59_00013520	ENOG4107U14	binding-protein-dependent transport systems inner membrane Component
HIMB59_00013540	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
HIMB59_00013550	ENOG4108RXX	maleylacetoacetate isomerase
HIMB59_00013560	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HIMB59_00013590	ENOG4107T0D	ABC, transporter
HIMB59_00013610	ENOG4105DP9	ABC transporter
HIMB59_00013620	ENOG4105C26	Dehydrogenase
HIMB59_00013660	ENOG4105DJP	Membrane
HIMB59_00013670	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HIMB59_00013690	ENOG4105CQC	Prephenate dehydratase
HIMB59_00013700	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HIMB59_00013720	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HIMB59_00013730	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HIMB59_00013740	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HIMB59_00013770	ENOG4105KJM	monovalent cation h antiporter subunit g
HIMB59_00013780	ENOG410684G	monovalent cation H antiporter subunit F
HIMB59_00013800	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HIMB59_00013810	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HIMB59_00013870	ENOG4105DQ4	alcohol dehydrogenase
HIMB59_00013880	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HIMB59_00013890	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HIMB59_00013900	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HIMB59_00013930	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HIMB59_00013940	ENOG4105CBT	Fructose-1,6-bisphosphatase
HIMB59_00013950	ENOG4105D6E	homoserine dehydrogenase
HIMB59_00013970	ENOG4108UJD	30S ribosomal protein S9
HIMB59_00013980	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HIMB59_00014010	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HIMB59_00014020	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HIMB59_00014040	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HIMB59_00014060	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HIMB59_00014070	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HIMB59_00014080	ENOG4108R6K	riboflavin synthase, subunit alpha
HIMB59_00014090	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HIMB59_00014100	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HIMB59_00014110	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HIMB59_00014140	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HIMB59_00014150	ENOG4105C3F	Signal peptidase i
HIMB59_00014160	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HIMB59_00014170	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HIMB59_00014180	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HIMB59_00014190	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HIMB59_00014200	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HIMB59_00014210	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HIMB59_00014230	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HIMB59_00014240	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HIMB59_00014250	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HIMB59_00014260	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HIMB59_00014270	ENOG4105CXT	aspartate transcarbamylase
HIMB59_00014280	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HIMB59_00014300	ENOG4105C9M	aspartyl-trna synthetase
HIMB59_00014330	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HIMB59_00014340	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HIMB59_00014350	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HIMB59_00014360	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HIMB59_00014390	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HIMB59_00014410	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HIMB59_00014420	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HIMB59_00014430	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HIMB59_00014440	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HIMB59_00014450	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HIMB59_00014460	ENOG4105CHR	reductase
HIMB59_00014480	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HIMB59_00014490	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HIMB59_00014500	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HIMB59_00014550	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HIMB59_00014570	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HIMB59_00014620	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HIMB59_00014650	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HIMB59_00014660	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HIMB59_00014680	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HIMB59_00014690	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HIMB59_00014720	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HIMB59_00014810	ENOG4105CAQ	asparagine synthetase
HIMB59_00014830	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HIMB59_00014910	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HIMB59_00014950	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HIMB59_00014980	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HIMB59_00015010	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HIMB59_00015070	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HIMB59_00015140	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HIMB59_00015170	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HIMB59_00015180	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HIMB59_00015190	ENOG4105C83	adenylosuccinate lyase
HIMB59_00015200	ENOG4107QPR	SAICAR synthetase
HIMB59_00015210	ENOG4108A1T	Phosphoribosylformylglycinamidine synthase, purS
HIMB59_00015220	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HIMB59_00015230	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
HIMB59_00015250	ENOG4105M2J	Glutaredoxin
HIMB59_00015260	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HIMB59_00015280	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HIMB59_00015290	ENOG4105C8N	cysteinyl-tRNA synthetase
HIMB59_00015300	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HIMB59_00015320	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase