locus-tag	class	description
HIMB59_00000020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HIMB59_00000030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HIMB59_00000060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIMB59_00000070	COG0174	glutamine synthetase
HIMB59_00000080	COG1177	transmembrane transport
HIMB59_00000090	COG1176	ABC-type spermidine putrescine transport system, permease component I
HIMB59_00000100	COG3842	ATPase activity
HIMB59_00000130	COG2957	Belongs to the agmatine deiminase family
HIMB59_00000170	COG0588	phosphoglycerate mutase activity
HIMB59_00000180	COG0114	fumarate hydratase activity
HIMB59_00000190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HIMB59_00000230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HIMB59_00000240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HIMB59_00000250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HIMB59_00000260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HIMB59_00000280	COG0564	pseudouridine synthase activity
HIMB59_00000290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HIMB59_00000300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIMB59_00000320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIMB59_00000340	COG0037	tRNA processing
HIMB59_00000360	COG2885	chlorophyll binding
HIMB59_00000370	COG0823	Involved in the tonB-independent uptake of proteins
HIMB59_00000420	COG0217	transcriptional regulatory protein
HIMB59_00000440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIMB59_00000470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HIMB59_00000490	COG1830	Aldolase
HIMB59_00000500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HIMB59_00000510	COG0483	inositol monophosphate 1-phosphatase activity
HIMB59_00000520	COG0254	rRNA binding
HIMB59_00000550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIMB59_00000570	COG1233	COG1233 Phytoene dehydrogenase and related
HIMB59_00000580	COG0415	Belongs to the DNA photolyase family
HIMB59_00000590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HIMB59_00000610	COG0156	8-amino-7-oxononanoate synthase activity
HIMB59_00000630	COG0181	hydroxymethylbilane synthase activity
HIMB59_00000640	COG0113	porphobilinogen synthase activity
HIMB59_00000650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HIMB59_00000660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HIMB59_00000700	COG0765	amino acid transport
HIMB59_00000790	COG1280	lysine exporter protein (LysE YggA)
HIMB59_00000840	COG1126	abc transporter atp-binding protein
HIMB59_00000850	COG0765	amino acid transport
HIMB59_00000860	COG4597	amino acid ABC transporter
HIMB59_00000870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIMB59_00000890	COG1136	(ABC) transporter
HIMB59_00000910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HIMB59_00000930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HIMB59_00000950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HIMB59_00000970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HIMB59_00000980	COG0668	transmembrane transport
HIMB59_00000990	COG0459	protein refolding
HIMB59_00001000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HIMB59_00001020	COG0709	Synthesizes selenophosphate from selenide and ATP
HIMB59_00001040	COG0785	Cytochrome C biogenesis protein
HIMB59_00001050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIMB59_00001080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIMB59_00001090	COG0494	nUDIX hydrolase
HIMB59_00001140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIMB59_00001160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HIMB59_00001210	COG3769	mannosylglycerate metabolic process
HIMB59_00001220	COG1215	transferase activity, transferring glycosyl groups
HIMB59_00001240	COG0516	GMP reductase activity
HIMB59_00001240	COG0517	IMP dehydrogenase activity
HIMB59_00001250	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HIMB59_00001270	COG1045	serine acetyltransferase
HIMB59_00001300	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HIMB59_00001320	COG4176	ABC-type proline glycine betaine transport system permease component
HIMB59_00001330	COG0517	IMP dehydrogenase activity
HIMB59_00001330	COG4175	Glycine betaine
HIMB59_00001390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB59_00001440	COG0386	Belongs to the glutathione peroxidase family
HIMB59_00001450	COG1733	regulation of RNA biosynthetic process
HIMB59_00001470	COG1741	Belongs to the pirin family
HIMB59_00001480	COG0004	ammonium transporteR
HIMB59_00001500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB59_00001570	COG0842	Transport permease protein
HIMB59_00001580	COG1131	(ABC) transporter
HIMB59_00001600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HIMB59_00001620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIMB59_00001630	COG1546	Belongs to the CinA family
HIMB59_00001630	COG1058	Belongs to the CinA family
HIMB59_00001640	COG0318	PFAM AMP-dependent synthetase and ligase
HIMB59_00001650	COG1024	Enoyl-CoA hydratase
HIMB59_00001690	COG4608	Belongs to the ABC transporter superfamily
HIMB59_00001700	COG0444	Belongs to the ABC transporter superfamily
HIMB59_00001710	COG0601	transmembrane transport
HIMB59_00001720	COG0747	negative chemotaxis
HIMB59_00001740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HIMB59_00001760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HIMB59_00001770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIMB59_00001780	COG3842	ATPase activity
HIMB59_00001790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIMB59_00001800	COG1840	ABC-type Fe3 transport system, periplasmic component
HIMB59_00001820	COG1121	(ABC) transporter
HIMB59_00001830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIMB59_00001850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HIMB59_00001860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HIMB59_00001870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HIMB59_00001880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HIMB59_00001910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HIMB59_00001920	COG0799	negative regulation of ribosome biogenesis
HIMB59_00001930	COG0793	Belongs to the peptidase S41A family
HIMB59_00001940	COG0494	nUDIX hydrolase
HIMB59_00001950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HIMB59_00001970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HIMB59_00001980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HIMB59_00001990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIMB59_00002000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIMB59_00002020	COG1218	3'(2'),5'-bisphosphate nucleotidase
HIMB59_00002030	COG0175	sulfate reduction
HIMB59_00002130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HIMB59_00002140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HIMB59_00002150	COG0594	ribonuclease P activity
HIMB59_00002160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HIMB59_00002170	COG0706	membrane insertase activity
HIMB59_00002180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HIMB59_00002200	COG2171	N-acyltransferase activity
HIMB59_00002210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HIMB59_00002240	COG0101	tRNA pseudouridine synthase activity
HIMB59_00002250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HIMB59_00002260	COG0242	peptide deformylase activity
HIMB59_00002280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIMB59_00002290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HIMB59_00002310	COG0077	Prephenate dehydratase
HIMB59_00002310	COG1605	Chorismate mutase
HIMB59_00002330	COG3474	cytochrome
HIMB59_00002340	COG2223	nitrite transmembrane transporter activity
HIMB59_00002360	COG1408	metallophosphoesterase
HIMB59_00002420	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB59_00002420	COG3347	Dehydrogenase
HIMB59_00002430	COG3842	ATPase activity
HIMB59_00002440	COG0371	Dehydrogenase
HIMB59_00002460	COG4221	oxidoreductase activity
HIMB59_00002470	COG1653	transport
HIMB59_00002480	COG1175	transmembrane transport
HIMB59_00002490	COG0395	ABC-type sugar transport system, permease component
HIMB59_00002500	COG0395	ABC-type sugar transport system, permease component
HIMB59_00002510	COG1349	DNA-binding transcription factor activity
HIMB59_00002520	COG0698	ribose 5-phosphate isomerase
HIMB59_00002540	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB59_00002560	COG1070	Carbohydrate kinase
HIMB59_00002580	COG0235	Class ii aldolase
HIMB59_00002600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIMB59_00002610	COG0583	DNA-binding transcription factor activity
HIMB59_00002620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HIMB59_00002630	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIMB59_00002640	COG0567	Dehydrogenase, E1 component
HIMB59_00002660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HIMB59_00002670	COG1053	succinate dehydrogenase
HIMB59_00002700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HIMB59_00002720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HIMB59_00002740	COG0183	Belongs to the thiolase family
HIMB59_00002750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIMB59_00002760	COG0824	Thioesterase
HIMB59_00002770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIMB59_00002800	COG0671	phosphoesterase, PA-phosphatase related
HIMB59_00002820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HIMB59_00002850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HIMB59_00002880	COG0473	3-isopropylmalate dehydrogenase activity
HIMB59_00002890	COG0066	3-isopropylmalate dehydratase activity
HIMB59_00002900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HIMB59_00002920	COG0336	Belongs to the RNA methyltransferase TrmD family
HIMB59_00002930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HIMB59_00002940	COG0228	four-way junction DNA binding
HIMB59_00002950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIMB59_00002960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HIMB59_00002970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HIMB59_00002980	COG0552	protein localization to endoplasmic reticulum
HIMB59_00002990	COG2917	probably involved in intracellular septation
HIMB59_00003000	COG0126	phosphoglycerate kinase activity
HIMB59_00003060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HIMB59_00003080	COG1329	Transcriptional regulator
HIMB59_00003090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HIMB59_00003130	COG4133	protoheme IX ABC transporter activity
HIMB59_00003150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HIMB59_00003160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HIMB59_00003170	COG1138	Cytochrome C-type biogenesis protein
HIMB59_00003180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HIMB59_00003190	COG3088	subunit of a heme lyase
HIMB59_00003210	COG4215	(ABC) transporter
HIMB59_00003230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIMB59_00003240	COG4598	ABC transporter
HIMB59_00003250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HIMB59_00003270	COG0137	argininosuccinate synthase activity
HIMB59_00003290	COG1595	DNA-templated transcription, initiation
HIMB59_00003320	COG2154	pterin-4-alpha-carbinolamine dehydratase
HIMB59_00003330	COG0667	Aldo Keto reductase
HIMB59_00003340	COG0670	Belongs to the BI1 family
HIMB59_00003390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HIMB59_00003410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIMB59_00003420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HIMB59_00003420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HIMB59_00003430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIMB59_00003440	COG0138	bifunctional purine biosynthesis protein purh
HIMB59_00003530	COG2192	nodulation
HIMB59_00003560	COG3118	belongs to the thioredoxin family
HIMB59_00003570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HIMB59_00003580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIMB59_00003590	COG1674	ftsk spoiiie
HIMB59_00003620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HIMB59_00003640	COG0457	Tetratricopeptide repeat
HIMB59_00003670	COG0495	leucyl-tRNA aminoacylation
HIMB59_00003700	COG1475	DNA binding
HIMB59_00003710	COG1192	Involved in chromosome partitioning
HIMB59_00003730	COG0445	tRNA wobble uridine modification
HIMB59_00003740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HIMB59_00003760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HIMB59_00003770	COG0424	maF-like protein
HIMB59_00003780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HIMB59_00003790	COG0237	dephospho-CoA kinase activity
HIMB59_00003800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIMB59_00003830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HIMB59_00003840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HIMB59_00003860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HIMB59_00003870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HIMB59_00003880	COG0107	imidazoleglycerol-phosphate synthase activity
HIMB59_00003890	COG0537	adenosine 5'-monophosphoramidase activity
HIMB59_00003910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HIMB59_00003930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HIMB59_00003940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HIMB59_00003950	COG1420	regulation of RNA biosynthetic process
HIMB59_00003960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HIMB59_00004050	COG0626	cystathionine gamma-synthase activity
HIMB59_00004060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HIMB59_00004120	COG0435	Glutathione S-transferase
HIMB59_00004130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIMB59_00004140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIMB59_00004150	COG0730	response to heat
HIMB59_00004170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HIMB59_00004200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HIMB59_00004210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HIMB59_00004240	COG1562	ergosterol biosynthetic process
HIMB59_00004300	COG0142	geranyltranstransferase activity
HIMB59_00004350	COG3386	PFAM SMP-30 Gluconolaconase
HIMB59_00004370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIMB59_00004400	COG1705	Flagellar rod assembly protein muramidase FlgJ
HIMB59_00004410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HIMB59_00004420	COG0180	Tryptophanyl-tRNA synthetase
HIMB59_00004440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HIMB59_00004460	COG0306	phosphate transporter
HIMB59_00004480	COG1012	belongs to the aldehyde dehydrogenase family
HIMB59_00004490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIMB59_00004520	COG1840	ABC-type Fe3 transport system, periplasmic component
HIMB59_00004530	COG3842	ATPase activity
HIMB59_00004550	COG5002	protein histidine kinase activity
HIMB59_00004570	COG0573	inorganic phosphate transmembrane transporter activity
HIMB59_00004590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HIMB59_00004600	COG0704	Plays a role in the regulation of phosphate uptake
HIMB59_00004610	COG0745	RESPONSE REGULATOR receiver
HIMB59_00004620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HIMB59_00004680	COG0438	transferase activity, transferring glycosyl groups
HIMB59_00004690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HIMB59_00004700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HIMB59_00004710	COG1702	phosphate starvation-inducible protein PhoH
HIMB59_00004730	COG4535	Mg2 and Co2 transporter CorC
HIMB59_00004740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HIMB59_00004750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HIMB59_00004760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HIMB59_00004760	COG0195	Participates in both transcription termination and antitermination
HIMB59_00004770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HIMB59_00004780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HIMB59_00004790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HIMB59_00004810	COG1185	polyribonucleotide nucleotidyltransferase activity
HIMB59_00004820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HIMB59_00004840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HIMB59_00004850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HIMB59_00004860	COG0756	dUTP diphosphatase activity
HIMB59_00004870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIMB59_00004880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIMB59_00004890	COG2226	methyltransferase
HIMB59_00004900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HIMB59_00004910	COG0268	Binds directly to 16S ribosomal RNA
HIMB59_00004930	COG0592	DNA-directed DNA polymerase activity
HIMB59_00004940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HIMB59_00004950	COG0187	DNA topoisomerase II activity
HIMB59_00004970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HIMB59_00004980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIMB59_00004980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIMB59_00005020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HIMB59_00005020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIMB59_00005030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIMB59_00005040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HIMB59_00005050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HIMB59_00005080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HIMB59_00005110	COG0006	proline dipeptidase activity
HIMB59_00005150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIMB59_00005160	COG1012	belongs to the aldehyde dehydrogenase family
HIMB59_00005200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIMB59_00005210	COG1116	anion transmembrane transporter activity
HIMB59_00005220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIMB59_00005230	COG0179	Fumarylacetoacetate (FAA) hydrolase
HIMB59_00005240	COG0318	PFAM AMP-dependent synthetase and ligase
HIMB59_00005320	COG0492	ferredoxin-NADP+ reductase activity
HIMB59_00005350	COG1063	alcohol dehydrogenase
HIMB59_00005370	COG1175	transmembrane transport
HIMB59_00005380	COG0395	ABC-type sugar transport system, permease component
HIMB59_00005390	COG3842	ATPase activity
HIMB59_00005400	COG3842	ATPase activity
HIMB59_00005410	COG2133	pyrroloquinoline quinone binding
HIMB59_00005420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIMB59_00005440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIMB59_00005450	COG3962	Belongs to the TPP enzyme family
HIMB59_00005470	COG2723	6-phospho-beta-galactosidase activity
HIMB59_00005480	COG3842	ATPase activity
HIMB59_00005500	COG0395	ABC-type sugar transport system, permease component
HIMB59_00005510	COG1175	transmembrane transport
HIMB59_00005520	COG1653	transport
HIMB59_00005540	COG5265	(ABC) transporter
HIMB59_00005560	COG1937	Protein conserved in bacteria
HIMB59_00005600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIMB59_00005700	COG1175	transmembrane transport
HIMB59_00005760	COG0123	including yeast histone deacetylase and acetoin utilization protein
HIMB59_00005790	COG1024	Enoyl-CoA hydratase
HIMB59_00005790	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIMB59_00005800	COG0318	PFAM AMP-dependent synthetase and ligase
HIMB59_00005820	COG0415	Belongs to the DNA photolyase family
HIMB59_00005830	COG1984	allophanate hydrolase subunit 2
HIMB59_00005840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HIMB59_00005850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HIMB59_00005910	COG0625	glutathione transferase activity
HIMB59_00005950	COG0285	dihydrofolate synthase activity
HIMB59_00005960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HIMB59_00005970	COG0159	tryptophan synthase activity
HIMB59_00005980	COG0133	tryptophan synthase activity
HIMB59_00005990	COG0135	phosphoribosylanthranilate isomerase activity
HIMB59_00006000	COG0284	orotidine-5'-phosphate decarboxylase activity
HIMB59_00006010	COG0776	regulation of translation
HIMB59_00006020	COG0539	negative regulation of cytoplasmic translation
HIMB59_00006040	COG1137	ATPase activity
HIMB59_00006070	COG0517	IMP dehydrogenase activity
HIMB59_00006070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HIMB59_00006100	COG1968	undecaprenyl-diphosphatase activity
HIMB59_00006130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIMB59_00006170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HIMB59_00006180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HIMB59_00006190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HIMB59_00006200	COG0072	phenylalanine-tRNA ligase activity
HIMB59_00006310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB59_00006350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB59_00006350	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIMB59_00006390	COG0205	6-phosphofructokinase activity
HIMB59_00006400	COG1940	carbohydrate kinase activity
HIMB59_00006430	COG0667	Aldo Keto reductase
HIMB59_00006440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIMB59_00006450	COG4154	Belongs to the RbsD FucU family
HIMB59_00006500	COG1070	Carbohydrate kinase
HIMB59_00006510	COG1072	(Pantothenic acid kinase))
HIMB59_00006560	COG3958	Transketolase
HIMB59_00006570	COG3959	Transketolase, thiamine diphosphate binding domain
HIMB59_00006590	COG1879	ABC-type sugar transport system periplasmic component
HIMB59_00006600	COG4214	carbohydrate transport
HIMB59_00006620	COG3836	Belongs to the HpcH HpaI aldolase family
HIMB59_00006630	COG0673	inositol 2-dehydrogenase activity
HIMB59_00006650	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB59_00006680	COG1129	ABC transporter
HIMB59_00006690	COG1172	Belongs to the binding-protein-dependent transport system permease family
HIMB59_00006710	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB59_00006720	COG0006	proline dipeptidase activity
HIMB59_00006730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIMB59_00006740	COG0022	dehydrogenase e1 component
HIMB59_00006750	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIMB59_00006800	COG0191	fructose-bisphosphate aldolase activity
HIMB59_00006810	COG2017	converts alpha-aldose to the beta-anomer
HIMB59_00006850	COG1131	(ABC) transporter
HIMB59_00006860	COG2115	Belongs to the xylose isomerase family
HIMB59_00006890	COG0673	inositol 2-dehydrogenase activity
HIMB59_00006920	COG1175	transmembrane transport
HIMB59_00006930	COG0395	ABC-type sugar transport system, permease component
HIMB59_00006950	COG3842	ATPase activity
HIMB59_00006960	COG3842	ATPase activity
HIMB59_00006980	COG2376	Dihydroxyacetone kinase
HIMB59_00007080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HIMB59_00007100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIMB59_00007150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIMB59_00007160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HIMB59_00007170	COG0287	Prephenate dehydrogenase
HIMB59_00007200	COG0019	diaminopimelate decarboxylase activity
HIMB59_00007220	COG0165	Argininosuccinate lyase
HIMB59_00007240	COG0400	carboxylic ester hydrolase activity
HIMB59_00007280	COG1238	metal cluster binding
HIMB59_00007300	COG1321	iron dependent repressor
HIMB59_00007310	COG1176	ABC-type spermidine putrescine transport system, permease component I
HIMB59_00007350	COG0196	riboflavin kinase activity
HIMB59_00007360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIMB59_00007390	COG0166	Belongs to the GPI family
HIMB59_00007410	COG1187	pseudouridine synthase activity
HIMB59_00007420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HIMB59_00007430	COG0590	tRNA wobble adenosine to inosine editing
HIMB59_00007480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HIMB59_00007480	COG1519	Transferase
HIMB59_00007490	COG2121	Domain of unknown function (DUF374)
HIMB59_00007500	COG1132	(ABC) transporter
HIMB59_00007530	COG1565	acr, cog1565
HIMB59_00007530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HIMB59_00007550	COG0109	protoheme IX farnesyltransferase activity
HIMB59_00007560	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HIMB59_00007590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HIMB59_00007610	COG0612	Peptidase, M16
HIMB59_00007660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HIMB59_00007670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIMB59_00007680	COG0356	it plays a direct role in the translocation of protons across the membrane
HIMB59_00007700	COG1196	nuclear chromosome segregation
HIMB59_00007730	COG1194	a g-specific adenine glycosylase
HIMB59_00007740	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HIMB59_00007750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIMB59_00007760	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIMB59_00007770	COG0741	lytic transglycosylase activity
HIMB59_00007820	COG0488	(ABC) transporter
HIMB59_00007830	COG0617	tRNA 3'-terminal CCA addition
HIMB59_00007840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HIMB59_00007860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HIMB59_00007870	COG2857	Cytochrome c1
HIMB59_00007870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HIMB59_00007880	COG0012	GTP binding
HIMB59_00007890	COG0193	aminoacyl-tRNA hydrolase activity
HIMB59_00007900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HIMB59_00007910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIMB59_00007940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HIMB59_00007960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HIMB59_00007980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIMB59_00008020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIMB59_00008050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIMB59_00008060	COG0322	excinuclease ABC activity
HIMB59_00008070	COG0686	Belongs to the AlaDH PNT family
HIMB59_00008080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HIMB59_00008090	COG0583	DNA-binding transcription factor activity
HIMB59_00008110	COG0326	Molecular chaperone. Has ATPase activity
HIMB59_00008120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HIMB59_00008150	COG0189	ligase activity
HIMB59_00008180	COG0556	nucleotide-excision repair
HIMB59_00008230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HIMB59_00008240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HIMB59_00008250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HIMB59_00008260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HIMB59_00008340	COG0174	glutamine synthetase
HIMB59_00008350	COG1454	alcohol dehydrogenase
HIMB59_00008380	COG0385	Bile acid
HIMB59_00008460	COG1238	metal cluster binding
HIMB59_00008480	COG0542	response to heat
HIMB59_00008500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIMB59_00008510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HIMB59_00008540	COG1530	ribonuclease E activity
HIMB59_00008610	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HIMB59_00008620	COG0489	protein tyrosine kinase activity
HIMB59_00008630	COG0330	HflC and HflK could
HIMB59_00008640	COG0330	HflC and HflK could
HIMB59_00008660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HIMB59_00008670	COG0028	Belongs to the TPP enzyme family
HIMB59_00008690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HIMB59_00008700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIMB59_00008740	COG0768	penicillin binding
HIMB59_00008750	COG0772	Belongs to the SEDS family
HIMB59_00008760	COG0662	Cupin 2, conserved barrel domain protein
HIMB59_00008760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HIMB59_00008790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HIMB59_00008800	COG0142	geranyltranstransferase activity
HIMB59_00008810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HIMB59_00008830	COG0423	glycine-tRNA ligase activity
HIMB59_00008870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIMB59_00008880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HIMB59_00008890	COG0300	oxidoreductase activity
HIMB59_00008900	COG3046	protein related to deoxyribodipyrimidine photolyase
HIMB59_00008920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HIMB59_00008930	COG1612	heme a metabolic process
HIMB59_00008940	COG0633	Ferredoxin
HIMB59_00008960	COG0167	dihydroorotate dehydrogenase activity
HIMB59_00008980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HIMB59_00009000	COG0343	queuine tRNA-ribosyltransferase activity
HIMB59_00009050	COG4536	flavin adenine dinucleotide binding
HIMB59_00009060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HIMB59_00009070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HIMB59_00009110	COG4974	Belongs to the 'phage' integrase family
HIMB59_00009120	COG0825	malonyl-CoA metabolic process
HIMB59_00009130	COG0653	protein targeting
HIMB59_00009160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIMB59_00009180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HIMB59_00009190	COG0527	aspartate kinase activity
HIMB59_00009210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HIMB59_00009220	COG0124	histidyl-tRNA synthetase
HIMB59_00009240	COG2890	protein-(glutamine-N5) methyltransferase activity
HIMB59_00009260	COG0739	heme binding
HIMB59_00009290	COG0683	leucine binding
HIMB59_00009360	COG0728	peptidoglycan biosynthetic process
HIMB59_00009420	COG2166	iron-sulfur cluster assembly
HIMB59_00009440	COG0492	ferredoxin-NADP+ reductase activity
HIMB59_00009470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIMB59_00009480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HIMB59_00009490	COG0505	Belongs to the CarA family
HIMB59_00009510	COG0358	DNA primase activity
HIMB59_00009520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HIMB59_00009570	COG0210	DNA helicase
HIMB59_00009580	COG0006	proline dipeptidase activity
HIMB59_00009590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HIMB59_00009600	COG0497	DNA recombination
HIMB59_00009620	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIMB59_00009640	COG2001	Belongs to the MraZ family
HIMB59_00009680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIMB59_00009700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HIMB59_00009710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HIMB59_00009720	COG0772	Belongs to the SEDS family
HIMB59_00009730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIMB59_00009730	COG0519	Catalyzes the synthesis of GMP from XMP
HIMB59_00009740	COG0123	including yeast histone deacetylase and acetoin utilization protein
HIMB59_00009750	COG1722	exodeoxyribonuclease VII activity
HIMB59_00009760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HIMB59_00009770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HIMB59_00009780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HIMB59_00009790	COG0259	pyridoxamine-phosphate oxidase activity
HIMB59_00009810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HIMB59_00009840	COG0730	response to heat
HIMB59_00009870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HIMB59_00009890	COG0303	'Molybdopterin
HIMB59_00009900	COG0425	Belongs to the sulfur carrier protein TusA family
HIMB59_00009900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIMB59_00009910	COG0583	DNA-binding transcription factor activity
HIMB59_00009930	COG3383	formate dehydrogenase (NAD+) activity
HIMB59_00009990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HIMB59_00010010	COG0250	Participates in transcription elongation, termination and antitermination
HIMB59_00010020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HIMB59_00010030	COG0081	regulation of translation
HIMB59_00010040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HIMB59_00010050	COG0222	ribosome binding
HIMB59_00010060	COG0085	RNA polymerase activity
HIMB59_00010070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIMB59_00010090	COG0049	tRNA binding
HIMB59_00010110	COG0051	transcription antitermination factor activity, RNA binding
HIMB59_00010120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HIMB59_00010130	COG0088	Forms part of the polypeptide exit tunnel
HIMB59_00010140	COG0089	rRNA binding
HIMB59_00010160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HIMB59_00010170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HIMB59_00010180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HIMB59_00010190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HIMB59_00010200	COG0255	Belongs to the universal ribosomal protein uL29 family
HIMB59_00010210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HIMB59_00010220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HIMB59_00010230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HIMB59_00010240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HIMB59_00010250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HIMB59_00010260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HIMB59_00010270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HIMB59_00010280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HIMB59_00010290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HIMB59_00010310	COG0201	protein transport
HIMB59_00010330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HIMB59_00010340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HIMB59_00010350	COG0202	RNA polymerase activity
HIMB59_00010380	COG0564	pseudouridine synthase activity
HIMB59_00010390	COG0321	lipoyl(octanoyl) transferase activity
HIMB59_00010410	COG2239	Acts as a magnesium transporter
HIMB59_00010430	COG1686	Belongs to the peptidase S11 family
HIMB59_00010480	COG0439	Biotin carboxylase
HIMB59_00010490	COG0511	ligase activity, forming carbon-carbon bonds
HIMB59_00010520	COG1530	ribonuclease E activity
HIMB59_00010530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HIMB59_00010540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HIMB59_00010600	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HIMB59_00010660	COG1022	Amp-dependent synthetase and ligase
HIMB59_00010690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIMB59_00010750	COG0174	glutamine synthetase
HIMB59_00010760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HIMB59_00010820	COG0525	valine-tRNA ligase activity
HIMB59_00010830	COG0129	dihydroxy-acid dehydratase activity
HIMB59_00010840	COG0708	Exodeoxyribonuclease III
HIMB59_00010850	COG0316	Belongs to the HesB IscA family
HIMB59_00010860	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HIMB59_00010870	COG0018	arginyl-trna synthetase
HIMB59_00010880	COG1472	Belongs to the glycosyl hydrolase 3 family
HIMB59_00010890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIMB59_00010900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HIMB59_00010920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HIMB59_00010930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HIMB59_00010940	COG0805	protein transport
HIMB59_00010980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIMB59_00010990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIMB59_00011010	COG0629	single-stranded DNA binding
HIMB59_00011020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HIMB59_00011030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HIMB59_00011060	COG0667	Aldo Keto reductase
HIMB59_00011070	COG2364	Membrane
HIMB59_00011080	COG0006	proline dipeptidase activity
HIMB59_00011110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIMB59_00011120	COG4172	Belongs to the ABC transporter superfamily
HIMB59_00011140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIMB59_00011190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HIMB59_00011200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HIMB59_00011240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HIMB59_00011280	COG1653	transport
HIMB59_00011290	COG1175	transmembrane transport
HIMB59_00011300	COG0395	ABC-type sugar transport system, permease component
HIMB59_00011310	COG0395	ABC-type sugar transport system, permease component
HIMB59_00011320	COG3842	ATPase activity
HIMB59_00011330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HIMB59_00011340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HIMB59_00011350	COG3842	ATPase activity
HIMB59_00011360	COG1176	ABC-type spermidine putrescine transport system, permease component I
HIMB59_00011370	COG1177	transmembrane transport
HIMB59_00011380	COG1012	belongs to the aldehyde dehydrogenase family
HIMB59_00011390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIMB59_00011410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HIMB59_00011420	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HIMB59_00011490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIMB59_00011550	COG2951	lytic endotransglycosylase activity
HIMB59_00011570	COG1686	Belongs to the peptidase S11 family
HIMB59_00011580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HIMB59_00011590	COG0470	DNA polymerase III
HIMB59_00011600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIMB59_00011610	COG0084	hydrolase, TatD family'
HIMB59_00011620	COG0321	lipoyl(octanoyl) transferase activity
HIMB59_00011620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HIMB59_00011630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIMB59_00011660	COG0484	heat shock protein binding
HIMB59_00011670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIMB59_00011680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIMB59_00011720	COG2135	peptidase activity
HIMB59_00011750	COG1666	GTP binding
HIMB59_00011770	COG0738	Major facilitator superfamily
HIMB59_00011810	COG3956	TIGRFAM MazG family protein
HIMB59_00011830	COG0583	DNA-binding transcription factor activity
HIMB59_00011840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIMB59_00011850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HIMB59_00011880	COG0436	Aminotransferase
HIMB59_00011890	COG2081	HI0933 family
HIMB59_00011910	COG3123	guanosine phosphorylase activity
HIMB59_00011930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIMB59_00011930	COG0519	Catalyzes the synthesis of GMP from XMP
HIMB59_00011960	COG0596	Alpha beta hydrolase
HIMB59_00011980	COG0646	methionine synthase
HIMB59_00011980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HIMB59_00012010	COG0410	ABC transporter
HIMB59_00012080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HIMB59_00012130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HIMB59_00012160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HIMB59_00012190	COG2084	Dehydrogenase
HIMB59_00012200	COG0483	inositol monophosphate 1-phosphatase activity
HIMB59_00012210	COG0569	domain protein
HIMB59_00012220	COG2204	response regulator
HIMB59_00012230	COG5000	phosphorelay sensor kinase activity
HIMB59_00012240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HIMB59_00012240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HIMB59_00012250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIMB59_00012260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIMB59_00012270	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIMB59_00012280	COG0022	dehydrogenase e1 component
HIMB59_00012280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIMB59_00012290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIMB59_00012300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIMB59_00012320	COG0148	phosphopyruvate hydratase activity
HIMB59_00012340	COG0504	CTP synthase activity
HIMB59_00012380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HIMB59_00012390	COG0512	Glutamine amidotransferase of anthranilate synthase
HIMB59_00012400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIMB59_00012410	COG0134	indole-3-glycerol-phosphate synthase activity
HIMB59_00012410	COG0135	phosphoribosylanthranilate isomerase activity
HIMB59_00012440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIMB59_00012450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIMB59_00012460	COG0372	Belongs to the citrate synthase family
HIMB59_00012490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIMB59_00012500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HIMB59_00012510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIMB59_00012520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIMB59_00012560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HIMB59_00012570	COG0233	cytoplasmic translational termination
HIMB59_00012580	COG0528	UMP kinase activity
HIMB59_00012590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HIMB59_00012600	COG0052	Belongs to the universal ribosomal protein uS2 family
HIMB59_00012610	COG0587	DNA-directed DNA polymerase activity
HIMB59_00012620	COG1136	(ABC) transporter
HIMB59_00012670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HIMB59_00012690	COG1007	ATP synthesis coupled electron transport
HIMB59_00012720	COG0713	ATP synthesis coupled electron transport
HIMB59_00012740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB59_00012750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HIMB59_00012760	COG1034	ATP synthesis coupled electron transport
HIMB59_00012770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIMB59_00012780	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HIMB59_00012790	COG0649	NAD binding
HIMB59_00012800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB59_00012810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB59_00012820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB59_00012860	COG0776	regulation of translation
HIMB59_00012870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HIMB59_00012890	COG0740	serine-type endopeptidase activity
HIMB59_00012900	COG0544	peptidyl-prolyl cis-trans isomerase activity
HIMB59_00012930	COG0347	Belongs to the P(II) protein family
HIMB59_00012950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HIMB59_00012960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIMB59_00012970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIMB59_00012980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HIMB59_00013010	COG0316	Belongs to the HesB IscA family
HIMB59_00013020	COG2151	metal-sulfur cluster biosynthetic enzyme
HIMB59_00013030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIMB59_00013040	COG0719	Fe-S assembly protein
HIMB59_00013050	COG0396	ATPase activity
HIMB59_00013060	COG0719	Fe-S assembly protein
HIMB59_00013070	COG0482	sulfurtransferase activity
HIMB59_00013080	COG2945	thiolester hydrolase activity
HIMB59_00013090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HIMB59_00013100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIMB59_00013110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIMB59_00013120	COG0174	glutamine synthetase
HIMB59_00013140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIMB59_00013140	COG0519	Catalyzes the synthesis of GMP from XMP
HIMB59_00013160	COG0004	ammonium transporteR
HIMB59_00013170	COG0174	glutamine synthetase
HIMB59_00013200	COG0069	glutamate synthase activity
HIMB59_00013220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIMB59_00013240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIMB59_00013270	COG0069	glutamate synthase activity
HIMB59_00013280	COG2218	PFAM glutamate synthase alpha subunit domain protein
HIMB59_00013290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIMB59_00013310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB59_00013310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIMB59_00013330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIMB59_00013360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB59_00013410	COG4176	ABC-type proline glycine betaine transport system permease component
HIMB59_00013420	COG4175	Glycine betaine
HIMB59_00013420	COG0517	IMP dehydrogenase activity
HIMB59_00013440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HIMB59_00013450	COG1960	acyl-CoA dehydrogenase activity
HIMB59_00013520	COG4176	ABC-type proline glycine betaine transport system permease component
HIMB59_00013530	COG2113	Glycine betaine
HIMB59_00013540	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HIMB59_00013560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HIMB59_00013570	COG1278	Cold shock
HIMB59_00013590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HIMB59_00013610	COG4143	(ABC) transporter
HIMB59_00013640	COG0346	lactoylglutathione lyase activity
HIMB59_00013660	COG0697	spore germination
HIMB59_00013670	COG0519	Catalyzes the synthesis of GMP from XMP
HIMB59_00013690	COG0077	Prephenate dehydratase
HIMB59_00013690	COG1605	Chorismate mutase
HIMB59_00013720	COG0651	ATP synthesis coupled electron transport
HIMB59_00013730	COG0651	ATP synthesis coupled electron transport
HIMB59_00013740	COG1006	Multisubunit Na H antiporter MnhC subunit
HIMB59_00013770	COG1320	monovalent cation:proton antiporter activity
HIMB59_00013780	COG2212	antiporter activity
HIMB59_00013800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HIMB59_00013810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HIMB59_00013870	COG1064	alcohol dehydrogenase
HIMB59_00013880	COG0045	succinate-CoA ligase (ADP-forming) activity
HIMB59_00013890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HIMB59_00013900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HIMB59_00013930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HIMB59_00013930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HIMB59_00013940	COG1494	fructose-1,6-bisphosphatase
HIMB59_00013950	COG0460	homoserine dehydrogenase
HIMB59_00013970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HIMB59_00013980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HIMB59_00014010	COG0776	regulation of translation
HIMB59_00014020	COG0416	fatty acid biosynthetic process
HIMB59_00014040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HIMB59_00014060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HIMB59_00014070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HIMB59_00014080	COG0307	riboflavin synthase, alpha
HIMB59_00014090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIMB59_00014100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HIMB59_00014110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HIMB59_00014130	COG1381	Involved in DNA repair and RecF pathway recombination
HIMB59_00014140	COG0571	ribonuclease III activity
HIMB59_00014150	COG0681	Belongs to the peptidase S26 family
HIMB59_00014160	COG0736	holo-[acyl-carrier-protein] synthase activity
HIMB59_00014170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HIMB59_00014180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIMB59_00014190	COG1758	RNA polymerase activity
HIMB59_00014200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HIMB59_00014210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIMB59_00014240	COG0154	amidase activity
HIMB59_00014250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIMB59_00014260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIMB59_00014270	COG0540	Belongs to the ATCase OTCase family
HIMB59_00014280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HIMB59_00014290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIMB59_00014300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HIMB59_00014330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HIMB59_00014340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIMB59_00014350	COG0105	UTP biosynthetic process
HIMB59_00014360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HIMB59_00014390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HIMB59_00014410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HIMB59_00014420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HIMB59_00014440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HIMB59_00014460	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB59_00014470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HIMB59_00014480	COG0360	Binds together with S18 to 16S ribosomal RNA
HIMB59_00014490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HIMB59_00014500	COG0359	binds to the 23S rRNA
HIMB59_00014520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HIMB59_00014550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIMB59_00014570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HIMB59_00014620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HIMB59_00014650	COG1183	phosphatidylcholine synthase activity
HIMB59_00014660	COG0688	phosphatidylethanolamine metabolic process
HIMB59_00014670	COG0538	isocitrate dehydrogenase activity
HIMB59_00014680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HIMB59_00014690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HIMB59_00014800	COG2192	nodulation
HIMB59_00014810	COG0367	asparagine synthase
HIMB59_00014830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HIMB59_00014910	COG1088	dTDP-glucose 4,6-dehydratase activity
HIMB59_00014950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HIMB59_00014980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HIMB59_00014980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HIMB59_00015010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HIMB59_00015070	COG0673	inositol 2-dehydrogenase activity
HIMB59_00015100	COG1215	transferase activity, transferring glycosyl groups
HIMB59_00015140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HIMB59_00015170	COG1489	DNA binding
HIMB59_00015180	COG0024	Methionine aminopeptidase
HIMB59_00015190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIMB59_00015200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HIMB59_00015210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIMB59_00015220	COG0047	phosphoribosylformylglycinamidine synthase activity
HIMB59_00015230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIMB59_00015250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HIMB59_00015260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HIMB59_00015280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIMB59_00015290	COG0215	cysteine-tRNA ligase activity
HIMB59_00015300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIMB59_00015320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase