locus-tag	class	description
AArcSl_0004	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AArcSl_0005	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArcSl_0009	COG2894	cell division
AArcSl_0013	COG1836	PFAM Integral membrane protein DUF92
AArcSl_0016	COG2986	histidine ammonia-lyase
AArcSl_0022	COG0489	protein tyrosine kinase activity
AArcSl_0029	COG1269	ATP hydrolysis coupled proton transport
AArcSl_0035	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AArcSl_0038	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArcSl_0039	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_0040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AArcSl_0041	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AArcSl_0042	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AArcSl_0043	COG0189	ligase activity
AArcSl_0046	COG0165	Argininosuccinate lyase
AArcSl_0047	COG0137	argininosuccinate synthase activity
AArcSl_0049	COG0504	CTP synthase activity
AArcSl_0050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArcSl_0050	COG0519	Catalyzes the synthesis of GMP from XMP
AArcSl_0056	COG2226	methyltransferase
AArcSl_0059	COG0181	hydroxymethylbilane synthase activity
AArcSl_0061	COG0560	Phosphoserine phosphatase
AArcSl_0062	COG1796	DNA polymerase
AArcSl_0062	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AArcSl_0074	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AArcSl_0077	COG1515	deoxyribonuclease V activity
AArcSl_0078	COG0009	L-threonylcarbamoyladenylate synthase
AArcSl_0079	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AArcSl_0080	COG0512	Glutamine amidotransferase of anthranilate synthase
AArcSl_0081	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArcSl_0084	COG0488	(ABC) transporter
AArcSl_0088	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AArcSl_0089	COG1797	cobyrinic acid a,c-diamide synthase activity
AArcSl_0095	COG3425	synthase
AArcSl_0106	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_0107	COG0037	tRNA processing
AArcSl_0108	COG0459	protein refolding
AArcSl_0110	COG0640	Transcriptional regulator
AArcSl_0115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_0118	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_0120	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_0121	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_0123	COG4166	transmembrane transport
AArcSl_0128	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_0131	COG1201	RNA secondary structure unwinding
AArcSl_0137	COG0589	response to stress
AArcSl_0139	COG0531	amino acid
AArcSl_0143	COG0463	Glycosyl transferase, family 2
AArcSl_0145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AArcSl_0148	COG1253	flavin adenine dinucleotide binding
AArcSl_0149	COG0306	phosphate transporter
AArcSl_0169	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArcSl_0169	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_0177	COG2271	Major facilitator Superfamily
AArcSl_0184	COG0179	Fumarylacetoacetate (FAA) hydrolase
AArcSl_0187	COG2217	Heavy metal translocating P-type atpase
AArcSl_0188	COG0492	ferredoxin-NADP+ reductase activity
AArcSl_0205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AArcSl_0218	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AArcSl_0226	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_0229	COG0430	RNA-3'-phosphate cyclase activity
AArcSl_0231	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AArcSl_0231	COG0517	IMP dehydrogenase activity
AArcSl_0233	COG0556	nucleotide-excision repair
AArcSl_0234	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AArcSl_0238	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AArcSl_0240	COG0560	Phosphoserine phosphatase
AArcSl_0247	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_0249	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AArcSl_0250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AArcSl_0253	COG0822	iron-sulfur transferase activity
AArcSl_0257	COG0572	uridine kinase
AArcSl_0259	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_0259	COG4651	solute:proton antiporter activity
AArcSl_0262	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AArcSl_0263	COG0343	queuine tRNA-ribosyltransferase activity
AArcSl_0268	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AArcSl_0269	COG0501	Belongs to the peptidase M48B family
AArcSl_0282	COG1169	isochorismate synthase
AArcSl_0284	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AArcSl_0284	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AArcSl_0287	COG1404	Belongs to the peptidase S8 family
AArcSl_0290	COG0644	oxidoreductase
AArcSl_0291	COG0733	neurotransmitter:sodium symporter activity
AArcSl_0294	COG0081	regulation of translation
AArcSl_0298	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AArcSl_0314	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AArcSl_0315	COG2234	aminopeptidase activity
AArcSl_0321	COG0534	Mate efflux family protein
AArcSl_0322	COG0626	cystathionine gamma-synthase activity
AArcSl_0329	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AArcSl_0331	COG0183	Belongs to the thiolase family
AArcSl_0333	COG2267	carboxylic ester hydrolase activity
AArcSl_0334	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArcSl_0336	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_0342	COG0215	cysteine-tRNA ligase activity
AArcSl_0347	COG0539	negative regulation of cytoplasmic translation
AArcSl_0361	COG1268	BioY protein
AArcSl_0362	COG1122	ATPase activity
AArcSl_0364	COG2181	nitrate reductase activity
AArcSl_0364	COG0247	lactate metabolic process
AArcSl_0365	COG0187	DNA topoisomerase II activity
AArcSl_0365	COG1372	Participates in initiation and elongation during chromosome replication
AArcSl_0366	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AArcSl_0370	COG0484	heat shock protein binding
AArcSl_0373	COG0587	DNA-directed DNA polymerase activity
AArcSl_0374	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AArcSl_0375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArcSl_0377	COG3842	ATPase activity
AArcSl_0379	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AArcSl_0380	COG0415	Belongs to the DNA photolyase family
AArcSl_0394	COG0765	amino acid transport
AArcSl_0396	COG0765	amino acid transport
AArcSl_0403	COG1695	Transcriptional regulator
AArcSl_0404	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AArcSl_0406	COG0022	dehydrogenase e1 component
AArcSl_0409	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AArcSl_0410	COG0640	Transcriptional regulator
AArcSl_0411	COG0798	PFAM Bile acid sodium symporter
AArcSl_0413	COG2339	peptidase activity
AArcSl_0415	COG1404	Belongs to the peptidase S8 family
AArcSl_0419	COG0640	Transcriptional regulator
AArcSl_0423	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_0433	COG0372	Belongs to the citrate synthase family
AArcSl_0434	COG0183	Belongs to the thiolase family
AArcSl_0438	COG0464	growth
AArcSl_0443	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AArcSl_0446	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AArcSl_0451	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_0457	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArcSl_0458	COG2086	electron transfer activity
AArcSl_0464	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
AArcSl_0465	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_0467	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AArcSl_0468	COG5598	trimethylamine methyltransferase
AArcSl_0470	COG5012	cobalamin binding
AArcSl_0471	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArcSl_0472	COG0589	response to stress
AArcSl_0473	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArcSl_0474	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AArcSl_0475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AArcSl_0476	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AArcSl_0477	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArcSl_0479	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AArcSl_0481	COG1960	acyl-CoA dehydrogenase activity
AArcSl_0483	COG0667	Aldo Keto reductase
AArcSl_0486	COG1012	belongs to the aldehyde dehydrogenase family
AArcSl_0487	COG1830	Aldolase
AArcSl_0488	COG0159	tryptophan synthase activity
AArcSl_0489	COG0133	tryptophan synthase activity
AArcSl_0490	COG0134	indole-3-glycerol-phosphate synthase activity
AArcSl_0510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AArcSl_0511	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AArcSl_0513	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AArcSl_0519	COG0673	inositol 2-dehydrogenase activity
AArcSl_0521	COG0010	Belongs to the arginase family
AArcSl_0522	COG1228	amidohydrolase
AArcSl_0523	COG1465	3-dehydroquinate synthase
AArcSl_0526	COG3573	Dehydrogenase
AArcSl_0531	COG1363	Peptidase, m42
AArcSl_0534	COG0471	metal ion transport
AArcSl_0534	COG3273	potassium ion transport
AArcSl_0535	COG1506	peptidase
AArcSl_0537	COG2894	cell division
AArcSl_0539	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArcSl_0540	COG0297	glycogen (starch) synthase activity
AArcSl_0541	COG0438	transferase activity, transferring glycosyl groups
AArcSl_0556	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AArcSl_0559	COG0616	signal peptide processing
AArcSl_0561	COG1803	Methylglyoxal synthase
AArcSl_0567	COG0519	Catalyzes the synthesis of GMP from XMP
AArcSl_0567	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArcSl_0569	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AArcSl_0570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AArcSl_0572	COG2133	pyrroloquinoline quinone binding
AArcSl_0573	COG0049	tRNA binding
AArcSl_0578	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AArcSl_0580	COG0085	RNA polymerase activity
AArcSl_0584	COG1022	Amp-dependent synthetase and ligase
AArcSl_0589	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AArcSl_0591	COG0003	Pfam Anion-transporting ATPase
AArcSl_0600	COG0309	Hydrogenase expression formation protein (HypE)
AArcSl_0601	COG0375	protein maturation
AArcSl_0602	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AArcSl_0603	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AArcSl_0610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_0611	COG3842	ATPase activity
AArcSl_0612	COG1177	transmembrane transport
AArcSl_0614	COG1840	ABC-type Fe3 transport system, periplasmic component
AArcSl_0616	COG0647	UMP catabolic process
AArcSl_0618	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AArcSl_0621	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArcSl_0622	COG1454	alcohol dehydrogenase
AArcSl_0624	COG1414	Transcriptional regulator
AArcSl_0631	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AArcSl_0632	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AArcSl_0633	COG1121	(ABC) transporter
AArcSl_0640	COG4974	Belongs to the 'phage' integrase family
AArcSl_0644	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AArcSl_0651	COG1074	ATP-dependent DNA helicase activity
AArcSl_0658	COG1401	restriction endodeoxyribonuclease activity
AArcSl_0673	COG0200	Binds to the 23S rRNA
AArcSl_0678	COG0322	excinuclease ABC activity
AArcSl_0679	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AArcSl_0680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AArcSl_0682	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AArcSl_0685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AArcSl_0688	COG0255	Belongs to the universal ribosomal protein uL29 family
AArcSl_0689	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AArcSl_0691	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AArcSl_0692	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AArcSl_0693	COG0089	rRNA binding
AArcSl_0694	COG0088	Forms part of the polypeptide exit tunnel
AArcSl_0695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AArcSl_0702	COG0517	IMP dehydrogenase activity
AArcSl_0703	COG0372	Belongs to the citrate synthase family
AArcSl_0706	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AArcSl_0709	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AArcSl_0712	COG2267	carboxylic ester hydrolase activity
AArcSl_0719	COG0247	lactate metabolic process
AArcSl_0719	COG0277	FAD linked oxidase domain protein
AArcSl_0720	COG1620	l-lactate permease
AArcSl_0722	COG1139	Iron-sulfur cluster binding protein
AArcSl_0740	COG1881	PFAM PEBP family protein
AArcSl_0745	COG2217	Heavy metal translocating P-type atpase
AArcSl_0766	COG1194	a g-specific adenine glycosylase
AArcSl_0768	COG0271	Belongs to the BolA IbaG family
AArcSl_0769	COG0114	fumarate hydratase activity
AArcSl_0770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AArcSl_0771	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AArcSl_0773	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AArcSl_0774	COG0540	Belongs to the ATCase OTCase family
AArcSl_0777	COG1252	NADH dehydrogenase
AArcSl_0778	COG0189	ligase activity
AArcSl_0781	COG0051	transcription antitermination factor activity, RNA binding
AArcSl_0782	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AArcSl_0783	COG0460	homoserine dehydrogenase
AArcSl_0787	COG5002	protein histidine kinase activity
AArcSl_0788	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_0789	COG0384	phenazine biosynthesis protein PhzF
AArcSl_0791	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArcSl_0791	COG0519	Catalyzes the synthesis of GMP from XMP
AArcSl_0799	COG0309	Hydrogenase expression formation protein (HypE)
AArcSl_0800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AArcSl_0801	COG1285	pathogenesis
AArcSl_0806	COG1278	Cold shock
AArcSl_0807	COG1960	acyl-CoA dehydrogenase activity
AArcSl_0813	COG1960	acyl-CoA dehydrogenase activity
AArcSl_0814	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AArcSl_0816	COG0517	IMP dehydrogenase activity
AArcSl_0822	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AArcSl_0830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AArcSl_0830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AArcSl_0832	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AArcSl_0835	COG4191	Histidine kinase
AArcSl_0838	COG2205	protein histidine kinase activity
AArcSl_0839	COG0714	Associated with various cellular activities
AArcSl_0843	COG0003	Pfam Anion-transporting ATPase
AArcSl_0844	COG0300	oxidoreductase activity
AArcSl_0849	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AArcSl_0856	COG2205	protein histidine kinase activity
AArcSl_0860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArcSl_0868	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AArcSl_0869	COG0142	geranyltranstransferase activity
AArcSl_0877	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AArcSl_0878	COG1151	hydroxylamine reductase activity
AArcSl_0880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AArcSl_0884	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AArcSl_0885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AArcSl_0891	COG0316	Belongs to the HesB IscA family
AArcSl_0897	COG0668	transmembrane transport
AArcSl_0903	COG1960	acyl-CoA dehydrogenase activity
AArcSl_0917	COG1201	RNA secondary structure unwinding
AArcSl_0918	COG0656	L-ascorbic acid biosynthetic process
AArcSl_0924	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AArcSl_0926	COG0647	UMP catabolic process
AArcSl_0928	COG1063	alcohol dehydrogenase
AArcSl_0936	COG1621	beta-fructofuranosidase activity
AArcSl_0938	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_0939	COG1078	dGTPase activity
AArcSl_0946	COG1278	Cold shock
AArcSl_0954	COG1605	Chorismate mutase
AArcSl_0954	COG0287	Prephenate dehydrogenase
AArcSl_0958	COG0531	amino acid
AArcSl_0959	COG0531	amino acid
AArcSl_0960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AArcSl_0964	COG0346	lactoylglutathione lyase activity
AArcSl_0969	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_0971	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AArcSl_0971	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AArcSl_0972	COG0673	inositol 2-dehydrogenase activity
AArcSl_0973	COG1082	Xylose isomerase domain protein TIM barrel
AArcSl_0974	COG0673	inositol 2-dehydrogenase activity
AArcSl_0977	COG3842	ATPase activity
AArcSl_0987	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AArcSl_0988	COG2890	protein-(glutamine-N5) methyltransferase activity
AArcSl_0989	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_0991	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArcSl_0992	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AArcSl_0994	COG1164	Oligoendopeptidase f
AArcSl_0995	COG0456	acetyltransferase
AArcSl_0997	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AArcSl_0998	COG0105	UTP biosynthetic process
AArcSl_1003	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AArcSl_1009	COG1355	regulation of microtubule-based process
AArcSl_1011	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArcSl_1014	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AArcSl_1015	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AArcSl_1019	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AArcSl_1022	COG0492	ferredoxin-NADP+ reductase activity
AArcSl_1028	COG0667	Aldo Keto reductase
AArcSl_1030	COG0459	protein refolding
AArcSl_1032	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArcSl_1036	COG4555	ABC transporter
AArcSl_1037	COG0166	Belongs to the GPI family
AArcSl_1039	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_1040	COG4608	Belongs to the ABC transporter superfamily
AArcSl_1041	COG0444	Belongs to the ABC transporter superfamily
AArcSl_1043	COG0601	transmembrane transport
AArcSl_1047	COG0284	orotidine-5'-phosphate decarboxylase activity
AArcSl_1049	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AArcSl_1050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AArcSl_1053	COG1335	isochorismatase
AArcSl_1058	COG1024	Enoyl-CoA hydratase
AArcSl_1061	COG1733	regulation of RNA biosynthetic process
AArcSl_1063	COG0475	glutathione-regulated potassium exporter activity
AArcSl_1063	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_1064	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_1064	COG4651	solute:proton antiporter activity
AArcSl_1075	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArcSl_1075	COG0235	Class ii aldolase
AArcSl_1079	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_1082	COG0151	Belongs to the GarS family
AArcSl_1083	COG0110	maltose O-acetyltransferase activity
AArcSl_1089	COG0530	calcium, potassium:sodium antiporter activity
AArcSl_1090	COG1234	tRNA 3'-trailer cleavage
AArcSl_1091	COG0435	Glutathione S-transferase
AArcSl_1093	COG0396	ATPase activity
AArcSl_1094	COG0719	Fe-S assembly protein
AArcSl_1095	COG0719	Fe-S assembly protein
AArcSl_1098	COG1051	belongs to the nudix hydrolase family
AArcSl_1099	COG0431	NADPH-dependent FMN reductase
AArcSl_1103	COG1064	alcohol dehydrogenase
AArcSl_1106	COG1111	helicase
AArcSl_1106	COG1205	dead DEAH box helicase
AArcSl_1107	COG0800	Aldolase
AArcSl_1109	COG1131	(ABC) transporter
AArcSl_1111	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AArcSl_1113	COG0596	Alpha beta hydrolase
AArcSl_1118	COG1331	Highly conserved protein containing a thioredoxin domain
AArcSl_1128	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AArcSl_1130	COG1522	sequence-specific DNA binding
AArcSl_1131	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1132	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1132	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_1133	COG1053	succinate dehydrogenase
AArcSl_1135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AArcSl_1139	COG0189	ligase activity
AArcSl_1141	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AArcSl_1145	COG0432	Pfam Uncharacterised protein family UPF0047
AArcSl_1151	COG2766	serine protein kinase
AArcSl_1156	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_1157	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_1158	COG0489	protein tyrosine kinase activity
AArcSl_1161	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AArcSl_1168	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AArcSl_1171	COG0133	tryptophan synthase activity
AArcSl_1172	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AArcSl_1175	COG5598	trimethylamine methyltransferase
AArcSl_1178	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_1178	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_1181	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AArcSl_1192	COG1067	ATP-dependent peptidase activity
AArcSl_1192	COG0470	DNA polymerase III
AArcSl_1196	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AArcSl_1198	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_1199	COG0668	transmembrane transport
AArcSl_1205	COG1233	COG1233 Phytoene dehydrogenase and related
AArcSl_1207	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArcSl_1207	COG0512	Glutamine amidotransferase of anthranilate synthase
AArcSl_1208	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArcSl_1209	COG0135	phosphoribosylanthranilate isomerase activity
AArcSl_1210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AArcSl_1213	COG0442	prolyl-tRNA aminoacylation
AArcSl_1216	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_1222	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArcSl_1223	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AArcSl_1237	COG3422	double-strand break repair
AArcSl_1239	COG0589	response to stress
AArcSl_1242	COG1321	iron dependent repressor
AArcSl_1244	COG0210	DNA helicase
AArcSl_1249	COG2309	aminopeptidase activity
AArcSl_1251	COG0559	Belongs to the binding-protein-dependent transport system permease family
AArcSl_1254	COG0410	ABC transporter
AArcSl_1256	COG0733	neurotransmitter:sodium symporter activity
AArcSl_1260	COG0651	ATP synthesis coupled electron transport
AArcSl_1261	COG0651	ATP synthesis coupled electron transport
AArcSl_1263	COG0651	ATP synthesis coupled electron transport
AArcSl_1267	COG1320	monovalent cation:proton antiporter activity
AArcSl_1315	COG0484	heat shock protein binding
AArcSl_1327	COG0101	tRNA pseudouridine synthase activity
AArcSl_1337	COG0667	Aldo Keto reductase
AArcSl_1342	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AArcSl_1353	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArcSl_1355	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AArcSl_1358	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArcSl_1360	COG0069	glutamate synthase activity
AArcSl_1360	COG0070	glutamate synthase
AArcSl_1360	COG0067	glutamate synthase
AArcSl_1362	COG1960	acyl-CoA dehydrogenase activity
AArcSl_1364	COG2212	antiporter activity
AArcSl_1365	COG1320	monovalent cation:proton antiporter activity
AArcSl_1368	COG1006	Multisubunit Na H antiporter MnhC subunit
AArcSl_1369	COG0651	ATP synthesis coupled electron transport
AArcSl_1370	COG0651	ATP synthesis coupled electron transport
AArcSl_1372	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_1373	COG0071	Belongs to the small heat shock protein (HSP20) family
AArcSl_1375	COG4191	Histidine kinase
AArcSl_1381	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AArcSl_1384	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_1386	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_1390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArcSl_1394	COG3833	ABC-type maltose transport systems, permease component
AArcSl_1395	COG1175	transmembrane transport
AArcSl_1397	COG3842	ATPase activity
AArcSl_1404	COG1640	4-alpha-glucanotransferase
AArcSl_1407	COG4221	oxidoreductase activity
AArcSl_1411	COG2226	methyltransferase
AArcSl_1414	COG0585	pseudouridine synthase activity
AArcSl_1417	COG0301	tRNA thio-modification
AArcSl_1418	COG0717	Belongs to the dCTP deaminase family
AArcSl_1421	COG0443	Heat shock 70 kDa protein
AArcSl_1425	COG0784	Response regulator, receiver
AArcSl_1425	COG4191	Histidine kinase
AArcSl_1427	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArcSl_1431	COG0126	phosphoglycerate kinase activity
AArcSl_1432	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AArcSl_1438	COG4770	biotin carboxylase activity
AArcSl_1442	COG1473	amidohydrolase
AArcSl_1450	COG0017	Asparaginyl-tRNA synthetase
AArcSl_1452	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_1453	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_1455	COG0589	response to stress
AArcSl_1470	COG1047	Peptidyl-prolyl cis-trans
AArcSl_1478	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_1481	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AArcSl_1482	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AArcSl_1484	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_1487	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AArcSl_1489	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_1492	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AArcSl_1496	COG1132	(ABC) transporter
AArcSl_1498	COG0805	protein transport
AArcSl_1499	COG0805	protein transport
AArcSl_1502	COG0235	Class ii aldolase
AArcSl_1503	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArcSl_1506	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AArcSl_1511	COG1196	nuclear chromosome segregation
AArcSl_1515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AArcSl_1516	COG2154	pterin-4-alpha-carbinolamine dehydratase
AArcSl_1519	COG0303	'Molybdopterin
AArcSl_1523	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AArcSl_1524	COG1215	transferase activity, transferring glycosyl groups
AArcSl_1529	COG1216	Glycosyl transferase, family 2
AArcSl_1531	COG2226	methyltransferase
AArcSl_1536	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AArcSl_1539	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1540	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_1546	COG0534	Mate efflux family protein
AArcSl_1548	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArcSl_1552	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AArcSl_1555	COG1234	tRNA 3'-trailer cleavage
AArcSl_1561	COG0823	Involved in the tonB-independent uptake of proteins
AArcSl_1561	COG1506	peptidase
AArcSl_1561	COG4946	Tricorn protease homolog
AArcSl_1563	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AArcSl_1565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AArcSl_1569	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AArcSl_1572	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AArcSl_1574	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArcSl_1577	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AArcSl_1581	COG0501	Belongs to the peptidase M48B family
AArcSl_1584	COG2239	Acts as a magnesium transporter
AArcSl_1585	COG2239	Acts as a magnesium transporter
AArcSl_1589	COG1757	Na H antiporter
AArcSl_1590	COG0501	Belongs to the peptidase M48B family
AArcSl_1594	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArcSl_1595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AArcSl_1596	COG1845	cytochrome c oxidase, subunit III
AArcSl_1615	COG1403	HNH endonuclease
AArcSl_1635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AArcSl_1636	COG0210	DNA helicase
AArcSl_1643	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AArcSl_1662	COG2153	protein acetylation
AArcSl_1697	COG0557	exoribonuclease II activity
AArcSl_1705	COG0113	porphobilinogen synthase activity
AArcSl_1709	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_1711	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AArcSl_1712	COG3639	organic phosphonate transmembrane transporter activity
AArcSl_1713	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AArcSl_1715	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArcSl_1722	COG0667	Aldo Keto reductase
AArcSl_1724	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AArcSl_1725	COG0095	Lipoate-protein ligase
AArcSl_1726	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_1727	COG2827	Endonuclease containing a URI domain
AArcSl_1730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AArcSl_1731	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AArcSl_1735	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AArcSl_1738	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AArcSl_1740	COG0018	arginyl-trna synthetase
AArcSl_1743	COG0633	Ferredoxin
AArcSl_1756	COG0405	Gamma-glutamyltransferase
AArcSl_1758	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArcSl_1759	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_1760	COG1575	Belongs to the MenA family. Type 1 subfamily
AArcSl_1764	COG1278	Cold shock
AArcSl_1765	COG0864	Transcriptional regulator
AArcSl_1766	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AArcSl_1769	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AArcSl_1782	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_1784	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AArcSl_1785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AArcSl_1785	COG0140	phosphoribosyl-ATP diphosphatase activity
AArcSl_1791	COG1136	(ABC) transporter
AArcSl_1791	COG0577	efflux transmembrane transporter activity
AArcSl_1792	COG0577	efflux transmembrane transporter activity
AArcSl_1792	COG1136	(ABC) transporter
AArcSl_1796	COG1131	(ABC) transporter
AArcSl_1804	COG0123	including yeast histone deacetylase and acetoin utilization protein
AArcSl_1807	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AArcSl_1810	COG3842	ATPase activity
AArcSl_1814	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AArcSl_1817	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AArcSl_1818	COG1151	hydroxylamine reductase activity
AArcSl_1820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AArcSl_1821	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AArcSl_1827	COG0322	excinuclease ABC activity
AArcSl_1828	COG0039	L-malate dehydrogenase activity
AArcSl_1834	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArcSl_1835	COG0626	cystathionine gamma-synthase activity
AArcSl_1839	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_1842	COG0175	sulfate reduction
AArcSl_1848	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1849	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1852	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_1852	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1853	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_1855	COG2878	Part of a membrane complex involved in electron transport
AArcSl_1856	COG0247	lactate metabolic process
AArcSl_1857	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArcSl_1858	COG2086	electron transfer activity
AArcSl_1864	COG0495	leucyl-tRNA aminoacylation
AArcSl_1865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AArcSl_1866	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_1868	COG1193	negative regulation of DNA recombination
AArcSl_1871	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_1872	COG2391	methyltransferase activity
AArcSl_1873	COG2391	methyltransferase activity
AArcSl_1874	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_1874	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArcSl_1875	COG0425	Belongs to the sulfur carrier protein TusA family
AArcSl_1876	COG2210	Belongs to the sulfur carrier protein TusA family
AArcSl_1877	COG3118	belongs to the thioredoxin family
AArcSl_1881	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AArcSl_1901	COG2226	methyltransferase
AArcSl_1904	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_1905	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_1911	COG0697	spore germination
AArcSl_1913	COG0644	oxidoreductase
AArcSl_1914	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArcSl_1915	COG2086	electron transfer activity
AArcSl_1918	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AArcSl_1924	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_1932	COG0346	lactoylglutathione lyase activity
AArcSl_1934	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArcSl_1937	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_1938	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_1941	COG3381	protein complex oligomerization
AArcSl_1942	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AArcSl_1944	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AArcSl_1948	COG0710	3-dehydroquinate dehydratase activity
AArcSl_1950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AArcSl_1951	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_1952	COG1522	sequence-specific DNA binding
AArcSl_1955	COG1024	Enoyl-CoA hydratase
AArcSl_1957	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AArcSl_1959	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AArcSl_1968	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AArcSl_1973	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AArcSl_1979	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArcSl_1982	COG3118	belongs to the thioredoxin family
AArcSl_1983	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AArcSl_1985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArcSl_1986	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AArcSl_1992	COG0330	HflC and HflK could
AArcSl_1995	COG0463	Glycosyl transferase, family 2
AArcSl_1998	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_2001	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AArcSl_2001	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AArcSl_2002	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AArcSl_2004	COG1063	alcohol dehydrogenase
AArcSl_2008	COG0436	Aminotransferase
AArcSl_2014	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AArcSl_2017	COG1271	oxidase subunit
AArcSl_2018	COG0459	protein refolding
AArcSl_2020	COG1446	asparaginase
AArcSl_2021	COG0024	Methionine aminopeptidase
AArcSl_2032	COG1691	(AIR) carboxylase
AArcSl_2033	COG1606	tRNA processing
AArcSl_2036	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArcSl_2037	COG1546	Belongs to the CinA family
AArcSl_2037	COG1058	Belongs to the CinA family
AArcSl_2041	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AArcSl_2050	COG4608	Belongs to the ABC transporter superfamily
AArcSl_2051	COG0444	Belongs to the ABC transporter superfamily
AArcSl_2052	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_2053	COG0601	transmembrane transport
AArcSl_2055	COG0601	transmembrane transport
AArcSl_2056	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_2057	COG0444	Belongs to the ABC transporter superfamily
AArcSl_2058	COG4608	Belongs to the ABC transporter superfamily
AArcSl_2063	COG1902	pentaerythritol trinitrate reductase activity
AArcSl_2066	COG0517	IMP dehydrogenase activity
AArcSl_2066	COG0516	GMP reductase activity
AArcSl_2070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AArcSl_2071	COG0521	Mo-molybdopterin cofactor biosynthetic process
AArcSl_2084	COG1045	serine acetyltransferase
AArcSl_2093	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_2100	COG0107	imidazoleglycerol-phosphate synthase activity
AArcSl_2101	COG0252	asparaginase activity
AArcSl_2102	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AArcSl_2106	COG0563	adenylate kinase activity
AArcSl_2114	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AArcSl_2120	COG0644	oxidoreductase
AArcSl_2122	COG2086	electron transfer activity
AArcSl_2123	COG0348	domain, Protein
AArcSl_2124	COG2239	Acts as a magnesium transporter
AArcSl_2130	COG0733	neurotransmitter:sodium symporter activity
AArcSl_2134	COG0280	phosphate acetyltransferase
AArcSl_2134	COG0281	malic enzyme
AArcSl_2137	COG3360	Dodecin
AArcSl_2138	COG1444	tRNA N-acetyltransferase activity
AArcSl_2140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AArcSl_2141	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_2144	COG1007	ATP synthesis coupled electron transport
AArcSl_2147	COG0713	ATP synthesis coupled electron transport
AArcSl_2150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArcSl_2151	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AArcSl_2152	COG0649	NAD binding
AArcSl_2153	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArcSl_2154	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArcSl_2155	COG0138	bifunctional purine biosynthesis protein purh
AArcSl_2158	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AArcSl_2159	COG0019	diaminopimelate decarboxylase activity
AArcSl_2160	COG2171	N-acyltransferase activity
AArcSl_2161	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AArcSl_2162	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AArcSl_2172	COG1744	ABC transporter substrate-binding protein PnrA-like
AArcSl_2174	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AArcSl_2176	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AArcSl_2177	COG0022	dehydrogenase e1 component
AArcSl_2179	COG0006	proline dipeptidase activity
AArcSl_2180	COG0714	Associated with various cellular activities
AArcSl_2187	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AArcSl_2189	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArcSl_2194	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AArcSl_2196	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AArcSl_2197	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AArcSl_2199	COG1492	cobalamin metabolic process
AArcSl_2200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_2201	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AArcSl_2203	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AArcSl_2204	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AArcSl_2210	COG1741	Belongs to the pirin family
AArcSl_2214	COG1174	glycine betaine transport
AArcSl_2222	COG1414	Transcriptional regulator
AArcSl_2224	COG3119	arylsulfatase activity
AArcSl_2225	COG1454	alcohol dehydrogenase
AArcSl_2228	COG0641	radical SAM
AArcSl_2240	COG1074	ATP-dependent DNA helicase activity
AArcSl_2242	COG1403	HNH endonuclease
AArcSl_2244	COG0210	DNA helicase
AArcSl_2263	COG4555	ABC transporter
AArcSl_2267	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_2268	COG0346	lactoylglutathione lyase activity
AArcSl_2269	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_2274	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArcSl_2278	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_2281	COG2379	hydroxypyruvate reductase
AArcSl_2290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AArcSl_2315	COG2814	Major facilitator Superfamily
AArcSl_2320	COG4533	DNA binding
AArcSl_2321	COG0601	transmembrane transport
AArcSl_2322	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_2323	COG0444	Belongs to the ABC transporter superfamily
AArcSl_2324	COG4608	Belongs to the ABC transporter superfamily
AArcSl_2325	COG1830	Aldolase
AArcSl_2326	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AArcSl_2330	COG1363	Peptidase, m42
AArcSl_2332	COG1196	nuclear chromosome segregation
AArcSl_2332	COG3264	Mechanosensitive ion channel
AArcSl_2334	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AArcSl_2334	COG0116	Belongs to the methyltransferase superfamily
AArcSl_2337	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AArcSl_2340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AArcSl_2344	COG2271	Major facilitator Superfamily
AArcSl_2352	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AArcSl_2352	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AArcSl_2353	COG0315	cyclic pyranopterin monophosphate synthase activity
AArcSl_2354	COG0589	response to stress
AArcSl_2355	COG4974	Belongs to the 'phage' integrase family
AArcSl_2357	COG0434	BtpA family
AArcSl_2358	COG0494	nUDIX hydrolase
AArcSl_2361	COG3976	FMN-binding domain protein
AArcSl_2361	COG1053	succinate dehydrogenase
AArcSl_2362	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_2365	COG0534	Mate efflux family protein
AArcSl_2369	COG0306	phosphate transporter
AArcSl_2372	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_2379	COG0535	radical SAM domain protein
AArcSl_2382	COG3404	Formiminotransferase-cyclodeaminase
AArcSl_2387	COG1140	nitrate reductase beta subunit
AArcSl_2388	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AArcSl_2390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AArcSl_2391	COG0723	plastoquinol--plastocyanin reductase activity
AArcSl_2397	COG0589	response to stress
AArcSl_2401	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_2402	COG0509	glycine decarboxylation via glycine cleavage system
AArcSl_2403	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AArcSl_2404	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AArcSl_2405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArcSl_2407	COG1522	sequence-specific DNA binding
AArcSl_2413	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AArcSl_2417	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AArcSl_2420	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AArcSl_2424	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_2425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_2425	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_2430	COG0471	metal ion transport
AArcSl_2432	COG1047	Peptidyl-prolyl cis-trans
AArcSl_2433	COG0531	amino acid
AArcSl_2434	COG1324	tolerance protein
AArcSl_2435	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_2453	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AArcSl_2461	COG1132	(ABC) transporter
AArcSl_2462	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AArcSl_2462	COG0778	Nitroreductase
AArcSl_2466	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_2467	COG0346	lactoylglutathione lyase activity
AArcSl_2476	COG5002	protein histidine kinase activity
AArcSl_2477	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArcSl_2484	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AArcSl_2485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AArcSl_2486	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AArcSl_2487	COG0247	lactate metabolic process
AArcSl_2490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AArcSl_2491	COG0303	'Molybdopterin
AArcSl_2492	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArcSl_2495	COG0709	Synthesizes selenophosphate from selenide and ATP
AArcSl_2496	COG3608	succinylglutamate desuccinylase aspartoacylase
AArcSl_2496	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AArcSl_2500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AArcSl_2503	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AArcSl_2503	COG2080	2 iron, 2 sulfur cluster binding
AArcSl_2508	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_2510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_2511	COG0549	Belongs to the carbamate kinase family
AArcSl_2512	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArcSl_2514	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AArcSl_2516	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_2517	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AArcSl_2518	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AArcSl_2519	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArcSl_2520	COG0840	transmembrane signaling receptor activity
AArcSl_2521	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AArcSl_2522	COG2252	PERMEase
AArcSl_2523	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AArcSl_2524	COG0778	Nitroreductase
AArcSl_2524	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AArcSl_2528	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArcSl_2531	COG2814	Major facilitator Superfamily
AArcSl_2532	COG1414	Transcriptional regulator
AArcSl_2537	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AArcSl_2541	COG1063	alcohol dehydrogenase
AArcSl_2542	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_2544	COG2267	carboxylic ester hydrolase activity
AArcSl_2546	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AArcSl_2547	COG1120	ATPase activity
AArcSl_2548	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AArcSl_2552	COG0252	asparaginase activity
AArcSl_2569	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AArcSl_2572	COG1078	dGTPase activity
AArcSl_2583	COG0318	PFAM AMP-dependent synthetase and ligase
AArcSl_2592	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AArcSl_2595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AArcSl_2596	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AArcSl_2600	COG0277	FAD linked oxidase domain protein
AArcSl_2606	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AArcSl_2607	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AArcSl_2615	COG0463	Glycosyl transferase, family 2
AArcSl_2615	COG1216	Glycosyl transferase, family 2
AArcSl_2616	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AArcSl_2618	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AArcSl_2619	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AArcSl_2621	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AArcSl_2626	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AArcSl_2628	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AArcSl_2629	COG0420	3'-5' exonuclease activity
AArcSl_2631	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArcSl_2632	COG0154	amidase activity
AArcSl_2633	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AArcSl_2636	COG0346	lactoylglutathione lyase activity
AArcSl_2641	COG0505	Belongs to the CarA family
AArcSl_2642	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AArcSl_2648	COG1278	Cold shock
AArcSl_2650	COG1233	COG1233 Phytoene dehydrogenase and related
AArcSl_2654	COG2197	response regulator
AArcSl_2660	COG0473	3-isopropylmalate dehydrogenase activity
AArcSl_2661	COG0066	3-isopropylmalate dehydratase activity
AArcSl_2662	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AArcSl_2664	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AArcSl_2666	COG0028	Belongs to the TPP enzyme family
AArcSl_2667	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AArcSl_2670	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AArcSl_2671	COG0083	homoserine kinase activity
AArcSl_2675	COG0535	radical SAM domain protein
AArcSl_2677	COG0604	alcohol dehydrogenase
AArcSl_2677	COG3321	synthase
AArcSl_2681	COG0243	molybdopterin cofactor binding
AArcSl_2682	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_2689	COG2135	peptidase activity
AArcSl_2693	COG0351	phosphomethylpyrimidine kinase
AArcSl_2696	COG0045	succinate-CoA ligase (ADP-forming) activity
AArcSl_2697	COG0857	belongs to the CobB CobQ family
AArcSl_2702	COG0531	amino acid
AArcSl_2712	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AArcSl_2715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AArcSl_2716	COG1234	tRNA 3'-trailer cleavage
AArcSl_2717	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AArcSl_2720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AArcSl_2721	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AArcSl_2726	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AArcSl_2729	COG0148	phosphopyruvate hydratase activity
AArcSl_2730	COG0052	Belongs to the universal ribosomal protein uS2 family
AArcSl_2731	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AArcSl_2732	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AArcSl_2733	COG2146	nitrite reductase [NAD(P)H] activity
AArcSl_2734	COG0484	heat shock protein binding
AArcSl_2737	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AArcSl_2738	COG0573	inorganic phosphate transmembrane transporter activity
AArcSl_2739	COG0573	inorganic phosphate transmembrane transporter activity
AArcSl_2740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArcSl_2745	COG0129	dihydroxy-acid dehydratase activity
AArcSl_2746	COG0483	inositol monophosphate 1-phosphatase activity
AArcSl_2747	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArcSl_2753	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_2757	COG3301	Polysulphide reductase, NrfD
AArcSl_2759	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AArcSl_2760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_2762	COG1607	acyl-coa hydrolase
AArcSl_2777	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_2789	COG2202	Pas domain
AArcSl_2789	COG1366	Belongs to the anti-sigma-factor antagonist family
AArcSl_2792	COG0702	epimerase
AArcSl_2794	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_2795	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_2799	COG0243	molybdopterin cofactor binding
AArcSl_2800	COG3381	protein complex oligomerization
AArcSl_2801	COG0151	Belongs to the GarS family
AArcSl_2806	COG3608	succinylglutamate desuccinylase aspartoacylase
AArcSl_2807	COG1840	ABC-type Fe3 transport system, periplasmic component
AArcSl_2815	COG1234	tRNA 3'-trailer cleavage
AArcSl_2816	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AArcSl_2821	COG0589	response to stress
AArcSl_2826	COG0589	response to stress
AArcSl_2830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArcSl_2831	COG1960	acyl-CoA dehydrogenase activity
AArcSl_2833	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArcSl_2834	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_2839	COG1252	NADH dehydrogenase
AArcSl_2840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_2843	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AArcSl_2848	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AArcSl_2850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_2852	COG1193	negative regulation of DNA recombination
AArcSl_2857	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AArcSl_2859	COG0142	geranyltranstransferase activity
AArcSl_2867	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_2868	COG0012	GTP binding
AArcSl_2874	COG1058	Belongs to the CinA family
AArcSl_2874	COG1546	Belongs to the CinA family
AArcSl_2882	COG0167	dihydroorotate dehydrogenase activity
AArcSl_2883	COG0525	valine-tRNA ligase activity
AArcSl_2889	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AArcSl_2891	COG0251	oxidation-reduction process
AArcSl_2896	COG1104	cysteine desulfurase activity
AArcSl_2898	COG0589	response to stress
AArcSl_2899	COG0508	dehydrogenase complex catalyzes the overall conversion of
AArcSl_2900	COG3199	ATP-NAD kinase
AArcSl_2901	COG0022	dehydrogenase e1 component
AArcSl_2902	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AArcSl_2903	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_2921	COG0728	peptidoglycan biosynthetic process
AArcSl_2941	COG1132	(ABC) transporter
AArcSl_2942	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_2943	COG2089	acid synthase
AArcSl_2944	COG1083	cytidylyl-transferase
AArcSl_2956	COG0463	Glycosyl transferase, family 2
AArcSl_2956	COG1216	Glycosyl transferase, family 2
AArcSl_2959	COG0438	transferase activity, transferring glycosyl groups
AArcSl_2960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AArcSl_2962	COG0438	transferase activity, transferring glycosyl groups
AArcSl_2977	COG3177	Filamentation induced by cAMP protein fic
AArcSl_2982	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_2983	COG0037	tRNA processing
AArcSl_2983	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AArcSl_2986	COG0601	transmembrane transport
AArcSl_2987	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_2990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AArcSl_2993	COG3422	double-strand break repair
AArcSl_3004	COG0589	response to stress
AArcSl_3011	COG0047	phosphoribosylformylglycinamidine synthase activity
AArcSl_3014	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AArcSl_3027	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AArcSl_3029	COG0077	Prephenate dehydratase
AArcSl_3029	COG1605	Chorismate mutase
AArcSl_3045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_3045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArcSl_3048	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AArcSl_3053	COG0471	metal ion transport
AArcSl_3053	COG3273	potassium ion transport
AArcSl_3059	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AArcSl_3061	COG0671	phosphoesterase, PA-phosphatase related
AArcSl_3061	COG2453	phosphatase
AArcSl_3091	COG0569	domain protein
AArcSl_3094	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AArcSl_3099	COG2409	Drug exporters of the RND superfamily
AArcSl_3108	COG2264	protein methyltransferase activity
AArcSl_3111	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArcSl_3112	COG0581	inorganic phosphate transmembrane transporter activity
AArcSl_3113	COG0573	inorganic phosphate transmembrane transporter activity
AArcSl_3118	COG2096	Adenosyltransferase
AArcSl_3125	COG1522	sequence-specific DNA binding
AArcSl_3126	COG0436	Aminotransferase
AArcSl_3127	COG0745	RESPONSE REGULATOR receiver
AArcSl_3129	COG0517	IMP dehydrogenase activity
AArcSl_3129	COG0516	GMP reductase activity
AArcSl_3134	COG3402	PFAM membrane-flanked domain
AArcSl_3135	COG3842	ATPase activity
AArcSl_3150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AArcSl_3179	COG1966	Carbon starvation protein
AArcSl_3180	COG0003	Pfam Anion-transporting ATPase
AArcSl_3183	COG0523	cobalamin synthesis protein
AArcSl_3187	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AArcSl_3188	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AArcSl_3195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArcSl_3196	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArcSl_3196	COG1648	precorrin-2 dehydrogenase activity
AArcSl_3208	COG1648	precorrin-2 dehydrogenase activity
AArcSl_3208	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArcSl_3210	COG1739	Uncharacterized protein family UPF0029
AArcSl_3212	COG0798	PFAM Bile acid sodium symporter
AArcSl_3216	COG3422	double-strand break repair
AArcSl_3222	COG0489	protein tyrosine kinase activity
AArcSl_3224	COG1063	alcohol dehydrogenase
AArcSl_3232	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AArcSl_3235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AArcSl_3238	COG0656	L-ascorbic acid biosynthetic process
AArcSl_3240	COG1940	carbohydrate kinase activity
AArcSl_3243	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AArcSl_3248	COG0131	Imidazoleglycerol-phosphate dehydratase
AArcSl_3264	COG0004	ammonium transporteR
AArcSl_3266	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AArcSl_3269	COG1253	flavin adenine dinucleotide binding
AArcSl_3270	COG0423	glycine-tRNA ligase activity
AArcSl_3272	COG0556	nucleotide-excision repair
AArcSl_3273	COG0330	HflC and HflK could
AArcSl_3282	COG0527	aspartate kinase activity
AArcSl_3283	COG0546	phosphoglycolate phosphatase activity
AArcSl_3285	COG0506	proline dehydrogenase activity