locus-tag	class	description
GM182_00020	COG2501	S4 domain
GM182_00035	COG1301	dicarboxylic acid transport
GM182_00050	COG0840	transmembrane signaling receptor activity
GM182_00070	COG2267	carboxylic ester hydrolase activity
GM182_00075	COG1473	amidohydrolase
GM182_00115	COG0840	transmembrane signaling receptor activity
GM182_00120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GM182_00165	COG1757	Na H antiporter
GM182_00175	COG1773	rubredoxin
GM182_00175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GM182_00180	COG3290	protein histidine kinase activity
GM182_00180	COG0840	transmembrane signaling receptor activity
GM182_00225	COG0516	GMP reductase activity
GM182_00225	COG0517	IMP dehydrogenase activity
GM182_00230	COG0519	Catalyzes the synthesis of GMP from XMP
GM182_00230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GM182_00245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GM182_00250	COG1215	transferase activity, transferring glycosyl groups
GM182_00290	COG1120	ATPase activity
GM182_00305	COG0840	transmembrane signaling receptor activity
GM182_00305	COG3290	protein histidine kinase activity
GM182_00310	COG3266	domain, Protein
GM182_00310	COG2911	Protein conserved in bacteria
GM182_00310	COG1361	Conserved repeat domain
GM182_00325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GM182_00325	COG0519	Catalyzes the synthesis of GMP from XMP
GM182_00340	COG1268	BioY protein
GM182_00365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GM182_00405	COG0312	modulator of DNA gyrase
GM182_00415	COG2703	oxygen carrier activity
GM182_00425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GM182_00435	COG0556	nucleotide-excision repair
GM182_00445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GM182_00460	COG0306	phosphate transporter
GM182_00465	COG0306	phosphate transporter
GM182_00475	COG2199	diguanylate cyclase activity
GM182_00475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GM182_00485	COG0484	heat shock protein binding
GM182_00535	COG0840	transmembrane signaling receptor activity
GM182_00545	COG2703	oxygen carrier activity
GM182_00550	COG1047	Peptidyl-prolyl cis-trans
GM182_00560	COG1132	(ABC) transporter
GM182_00565	COG1132	(ABC) transporter
GM182_00575	COG3706	GGDEF domain
GM182_00600	COG1979	alcohol dehydrogenase
GM182_00605	COG1979	alcohol dehydrogenase
GM182_00620	COG1597	lipid kinase activity
GM182_00635	COG1704	LemA family
GM182_00640	COG1757	Na H antiporter
GM182_00650	COG3584	3D domain protein
GM182_00670	COG0419	ATPase involved in DNA repair
GM182_00680	COG0585	pseudouridine synthase activity
GM182_00690	COG1739	Uncharacterized protein family UPF0029
GM182_00695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM182_00730	COG3290	protein histidine kinase activity
GM182_00730	COG0840	transmembrane signaling receptor activity
GM182_00735	COG0312	modulator of DNA gyrase
GM182_00740	COG0312	modulator of DNA gyrase
GM182_00745	COG3290	protein histidine kinase activity
GM182_00745	COG0840	transmembrane signaling receptor activity
GM182_00750	COG1361	Conserved repeat domain
GM182_00755	COG0601	transmembrane transport
GM182_00760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GM182_00765	COG0444	Belongs to the ABC transporter superfamily
GM182_00770	COG4608	Belongs to the ABC transporter superfamily
GM182_00780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GM182_00790	COG2814	Major facilitator Superfamily
GM182_00825	COG4716	Myosin-crossreactive antigen
GM182_00830	COG0583	DNA-binding transcription factor activity
GM182_00850	COG1307	EDD domain protein, DegV family
GM182_00860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM182_00865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GM182_00870	COG0358	DNA primase activity
GM182_00905	COG0038	chloride channel
GM182_00940	COG0463	Glycosyl transferase, family 2
GM182_00945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GM182_00955	COG1215	transferase activity, transferring glycosyl groups
GM182_00975	COG1131	(ABC) transporter
GM182_01015	COG0492	ferredoxin-NADP+ reductase activity
GM182_01020	COG2358	TRAP transporter, solute receptor (TAXI family
GM182_01055	COG0864	Transcriptional regulator
GM182_01070	COG2409	Drug exporters of the RND superfamily
GM182_01080	COG2199	diguanylate cyclase activity
GM182_01080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GM182_01100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GM182_01110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GM182_01115	COG1214	PFAM Peptidase M22, glycoprotease
GM182_01120	COG1433	Dinitrogenase iron-molybdenum cofactor
GM182_01140	COG0037	tRNA processing
GM182_01155	COG0584	glycerophosphoryl diester phosphodiesterase
GM182_01165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GM182_01165	COG1796	DNA polymerase
GM182_01195	COG2226	methyltransferase
GM182_01205	COG1863	multisubunit Na H antiporter MnhE subunit
GM182_01210	COG2212	antiporter activity
GM182_01215	COG1320	monovalent cation:proton antiporter activity
GM182_01225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GM182_01225	COG2111	Na H antiporter
GM182_01230	COG1006	Multisubunit Na H antiporter MnhC subunit
GM182_01235	COG0651	ATP synthesis coupled electron transport
GM182_01250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM182_01260	COG0649	NAD binding
GM182_01275	COG2226	methyltransferase
GM182_01295	COG0330	HflC and HflK could
GM182_01300	COG0330	HflC and HflK could
GM182_01335	COG1966	Carbon starvation protein
GM182_01360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GM182_01365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GM182_01370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GM182_01375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GM182_01395	COG1175	transmembrane transport
GM182_01400	COG3833	ABC-type maltose transport systems, permease component
GM182_01405	COG0366	Alpha amylase catalytic
GM182_01405	COG3103	Sh3 type 3 domain protein
GM182_01425	COG1418	mRNA catabolic process
GM182_01465	COG0752	glycyl-tRNA synthetase alpha subunit
GM182_01470	COG0751	glycine-tRNA ligase activity
GM182_01475	COG3706	GGDEF domain
GM182_01485	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GM182_01490	COG0037	tRNA processing
GM182_01495	COG1475	DNA binding
GM182_01505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GM182_01515	COG1773	rubredoxin
GM182_01520	COG0426	domain, Protein
GM182_01525	COG0432	Pfam Uncharacterised protein family UPF0047
GM182_01545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GM182_01550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GM182_01555	COG3584	3D domain protein
GM182_01555	COG1388	LysM domain
GM182_01570	COG0445	tRNA wobble uridine modification
GM182_01575	COG0482	sulfurtransferase activity
GM182_01585	COG2151	metal-sulfur cluster biosynthetic enzyme
GM182_01595	COG0835	chemotaxis
GM182_01615	COG0281	malic enzyme
GM182_01620	COG1776	CheC inhibitor of MCP methylation
GM182_01620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GM182_01645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GM182_01650	COG0594	ribonuclease P activity
GM182_01655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GM182_01660	COG0706	membrane insertase activity
GM182_01670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GM182_01700	COG0516	GMP reductase activity
GM182_01700	COG0517	IMP dehydrogenase activity
GM182_01705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GM182_01745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GM182_01755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GM182_01765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GM182_01770	COG0356	it plays a direct role in the translocation of protons across the membrane
GM182_01785	COG0737	Belongs to the 5'-nucleotidase family
GM182_01795	COG0725	ABC transporter, periplasmic molybdate-binding protein
GM182_01800	COG3842	ATPase activity
GM182_01830	COG0402	S-adenosylhomocysteine deaminase activity
GM182_01845	COG1175	transmembrane transport
GM182_01850	COG0395	ABC-type sugar transport system, permease component
GM182_01870	COG1215	transferase activity, transferring glycosyl groups
GM182_01875	COG0737	Belongs to the 5'-nucleotidase family
GM182_01880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GM182_01895	COG0330	HflC and HflK could
GM182_01905	COG0012	GTP binding
GM182_01915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GM182_01920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GM182_01930	COG0306	phosphate transporter
GM182_01935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GM182_01940	COG0525	valine-tRNA ligase activity
GM182_01945	COG1492	cobalamin metabolic process
GM182_01980	COG0574	Belongs to the PEP-utilizing enzyme family
GM182_01980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GM182_01985	COG0446	pyridine nucleotide-disulphide oxidoreductase
GM182_01990	COG2070	2-Nitropropane dioxygenase
GM182_01995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GM182_02000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GM182_02005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GM182_02015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GM182_02020	COG0416	fatty acid biosynthetic process
GM182_02025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM182_02030	COG0571	ribonuclease III activity
GM182_02035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM182_02040	COG0552	protein localization to endoplasmic reticulum
GM182_02040	COG0457	Tetratricopeptide repeat
GM182_02055	COG0822	iron-sulfur transferase activity
GM182_02065	COG0693	protein deglycase activity
GM182_02085	COG0585	pseudouridine synthase activity
GM182_02090	COG2814	Major facilitator Superfamily
GM182_02105	COG1078	dGTPase activity
GM182_02185	COG3885	ferrous iron binding
GM182_02185	COG2078	PFAM AMMECR1 domain protein
GM182_02195	COG1077	Cell shape determining protein MreB Mrl
GM182_02205	COG0768	penicillin binding
GM182_02215	COG2894	cell division
GM182_02220	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GM182_02225	COG0772	Belongs to the SEDS family
GM182_02230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM182_02245	COG0357	Ribosomal RNA small subunit methyltransferase G
GM182_02260	COG0860	N-Acetylmuramoyl-L-alanine amidase
GM182_02265	COG1316	TRANSCRIPTIONal
GM182_02275	COG0187	DNA topoisomerase II activity
GM182_02280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GM182_02285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GM182_02295	COG0424	maF-like protein
GM182_02320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GM182_02325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GM182_02330	COG2204	response regulator
GM182_02335	COG3842	ATPase activity
GM182_02345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GM182_02355	COG0235	Class ii aldolase
GM182_02360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GM182_02365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GM182_02385	COG1187	pseudouridine synthase activity
GM182_02390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GM182_02400	COG1929	Belongs to the glycerate kinase type-1 family
GM182_02410	COG0501	Belongs to the peptidase M48B family
GM182_02430	COG0482	sulfurtransferase activity
GM182_02440	COG0314	molybdopterin synthase activity
GM182_02460	COG0166	Belongs to the GPI family
GM182_02470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GM182_02475	COG0492	ferredoxin-NADP+ reductase activity
GM182_02480	COG0697	spore germination
GM182_02490	COG0045	succinate-CoA ligase (ADP-forming) activity
GM182_02495	COG1543	Belongs to the glycosyl hydrolase 57 family
GM182_02500	COG1449	Belongs to the glycosyl hydrolase 57 family
GM182_02510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GM182_02515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GM182_02515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GM182_02575	COG2226	methyltransferase
GM182_02585	COG1851	Uncharacterised protein family (UPF0128)
GM182_02590	COG0151	Belongs to the GarS family
GM182_02595	COG0085	RNA polymerase activity
GM182_02600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GM182_02620	COG1461	Dihydroxyacetone kinase
GM182_02625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GM182_02630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GM182_02635	COG0742	ribosomal rna small subunit methyltransferase
GM182_02640	COG0561	phosphatase activity
GM182_02645	COG0280	phosphate acetyltransferase
GM182_02655	COG2270	Major facilitator Superfamily
GM182_02675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM182_02680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GM182_02690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GM182_02695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GM182_02700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GM182_02705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GM182_02710	COG1253	flavin adenine dinucleotide binding
GM182_02740	COG1111	helicase
GM182_02740	COG1205	dead DEAH box helicase
GM182_02775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GM182_02780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GM182_02790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GM182_02790	COG2111	Na H antiporter
GM182_02795	COG1006	Multisubunit Na H antiporter MnhC subunit
GM182_02855	COG0542	response to heat
GM182_02860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GM182_02865	COG4956	integral membrane protein (PIN domain superfamily)
GM182_02870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GM182_02870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GM182_02875	COG0215	cysteine-tRNA ligase activity
GM182_02880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GM182_02885	COG0205	6-phosphofructokinase activity
GM182_02950	COG0052	Belongs to the universal ribosomal protein uS2 family
GM182_02955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GM182_02960	COG0528	UMP kinase activity
GM182_02965	COG0233	cytoplasmic translational termination
GM182_02975	COG0575	Belongs to the CDS family
GM182_02980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GM182_02990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GM182_02995	COG0442	prolyl-tRNA aminoacylation
GM182_03005	COG2313	pseudouridylate synthase activity
GM182_03020	COG1028	Short-chain dehydrogenase reductase Sdr
GM182_03025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GM182_03030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GM182_03040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GM182_03050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GM182_03055	COG0154	amidase activity
GM182_03060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GM182_03065	COG0587	DNA-directed DNA polymerase activity
GM182_03075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GM182_03090	COG0285	dihydrofolate synthase activity
GM182_03095	COG0095	Lipoate-protein ligase
GM182_03110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GM182_03130	COG0446	pyridine nucleotide-disulphide oxidoreductase
GM182_03130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GM182_03160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GM182_03170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GM182_03175	COG1105	Belongs to the carbohydrate kinase PfkB family
GM182_03195	COG0537	adenosine 5'-monophosphoramidase activity
GM182_03200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GM182_03215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GM182_03225	COG0037	tRNA processing
GM182_03235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GM182_03240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM182_03240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM182_03245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM182_03245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GM182_03255	COG0346	lactoylglutathione lyase activity
GM182_03270	COG4770	biotin carboxylase activity
GM182_03275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GM182_03280	COG2986	histidine ammonia-lyase
GM182_03285	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GM182_03290	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GM182_03295	COG0217	transcriptional regulatory protein
GM182_03300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GM182_03305	COG0632	four-way junction helicase activity
GM182_03310	COG2255	four-way junction helicase activity
GM182_03315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GM182_03320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GM182_03325	COG0343	queuine tRNA-ribosyltransferase activity
GM182_03330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GM182_03335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GM182_03340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GM182_03345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GM182_03350	COG1490	D-aminoacyl-tRNA deacylase activity
GM182_03365	COG0268	Binds directly to 16S ribosomal RNA
GM182_03370	COG1141	Ferredoxin
GM182_03410	COG1815	bacterial-type flagellum-dependent cell motility
GM182_03425	COG1766	The M ring may be actively involved in energy transduction
GM182_03430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GM182_03440	COG1157	protein secretion by the type III secretion system
GM182_03495	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GM182_03500	COG1776	CheC inhibitor of MCP methylation
GM182_03500	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GM182_03505	COG2201	protein-glutamate methylesterase activity
GM182_03515	COG1338	Plays a role in the flagellum-specific transport system
GM182_03535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GM182_03540	COG1419	protein localization to endoplasmic reticulum
GM182_03555	COG2201	protein-glutamate methylesterase activity
GM182_03560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GM182_03570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GM182_03575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GM182_03585	COG0674	pyruvate-flavodoxin oxidoreductase activity
GM182_03590	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM182_03600	COG0647	UMP catabolic process
GM182_03610	COG1362	aminopeptidase activity
GM182_03615	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GM182_03625	COG0138	bifunctional purine biosynthesis protein purh
GM182_03635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GM182_03640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GM182_03645	COG0138	bifunctional purine biosynthesis protein purh
GM182_03650	COG0151	Belongs to the GarS family
GM182_03655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GM182_03660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GM182_03665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GM182_03670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GM182_03675	COG0047	phosphoribosylformylglycinamidine synthase activity
GM182_03680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GM182_03685	COG0275	rRNA processing
GM182_03695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GM182_03700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GM182_03705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GM182_03710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GM182_03715	COG0772	Belongs to the SEDS family
GM182_03720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GM182_03725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GM182_03730	COG1160	GTP binding
GM182_03735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GM182_03740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GM182_03740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GM182_03755	COG0493	'glutamate synthase
GM182_03775	COG0126	phosphoglycerate kinase activity
GM182_03775	COG0149	triose-phosphate isomerase activity
GM182_03780	COG0149	triose-phosphate isomerase activity
GM182_03790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GM182_03800	COG0756	dUTP diphosphatase activity
GM182_03805	COG1573	uracil-dna glycosylase
GM182_03810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GM182_03830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GM182_03850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GM182_03860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GM182_03860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GM182_03865	COG0084	hydrolase, TatD family'
GM182_03875	COG0674	pyruvate-flavodoxin oxidoreductase activity
GM182_03875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GM182_03880	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM182_03890	COG0148	phosphopyruvate hydratase activity
GM182_03900	COG0569	domain protein
GM182_03905	COG4974	Belongs to the 'phage' integrase family
GM182_03940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM182_03945	COG0504	CTP synthase activity
GM182_03950	COG0018	arginyl-trna synthetase
GM182_03970	COG2226	methyltransferase
GM182_03975	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GM182_03995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GM182_04000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GM182_04005	COG0736	holo-[acyl-carrier-protein] synthase activity
GM182_04020	COG1394	ATPase activity, coupled to movement of substances
GM182_04025	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GM182_04075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GM182_04090	COG1481	regulation of sporulation
GM182_04095	COG1660	Displays ATPase and GTPase activities
GM182_04105	COG0322	excinuclease ABC activity
GM182_04110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GM182_04120	COG0237	dephospho-CoA kinase activity
GM182_04125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GM182_04140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GM182_04150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GM182_04155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GM182_04160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GM182_04165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GM182_04170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GM182_04175	COG0698	ribose 5-phosphate isomerase
GM182_04180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GM182_04185	COG0402	S-adenosylhomocysteine deaminase activity
GM182_04190	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GM182_04195	COG0758	DNA mediated transformation
GM182_04200	COG0606	chelatase, subunit chli
GM182_04205	COG0792	nuclease activity
GM182_04215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GM182_04220	COG0335	large ribosomal subunit rRNA binding
GM182_04225	COG4752	Belongs to the RNA methyltransferase TrmD family
GM182_04230	COG0336	Belongs to the RNA methyltransferase TrmD family
GM182_04235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GM182_04250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GM182_04255	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GM182_04265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GM182_04270	COG0564	pseudouridine synthase activity
GM182_04275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GM182_04280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GM182_04285	COG0720	synthase
GM182_04290	COG1469	GTP cyclohydrolase I activity
GM182_04295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GM182_04305	COG1040	competence protein
GM182_04320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GM182_04325	COG0849	cell division
GM182_04340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GM182_04345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM182_04350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GM182_04355	COG2264	protein methyltransferase activity
GM182_04360	COG1420	regulation of RNA biosynthetic process
GM182_04380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GM182_04390	COG1181	Belongs to the D-alanine--D-alanine ligase family
GM182_04400	COG0105	UTP biosynthetic process
GM182_04405	COG0071	Belongs to the small heat shock protein (HSP20) family
GM182_04410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GM182_04415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GM182_04435	COG0011	TIGRFAM Protein of
GM182_04445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GM182_04455	COG0194	GDP metabolic process
GM182_04460	COG2052	Domain of unknown function (DUF370)
GM182_04465	COG1561	YicC-like family, N-terminal region
GM182_04470	COG1063	alcohol dehydrogenase
GM182_04475	COG0436	Aminotransferase
GM182_04480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GM182_04485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GM182_04490	COG0180	Tryptophanyl-tRNA synthetase
GM182_04495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GM182_04500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GM182_04505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM182_04510	COG1692	metallophosphoesterase
GM182_04515	COG1418	mRNA catabolic process
GM182_04525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GM182_04530	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GM182_04535	COG1546	Belongs to the CinA family
GM182_04535	COG1058	Belongs to the CinA family
GM182_04540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GM182_04550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GM182_04555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GM182_04560	COG0740	serine-type endopeptidase activity
GM182_04605	COG1435	thymidine kinase activity
GM182_04625	COG1994	Peptidase M50
GM182_04630	COG0517	IMP dehydrogenase activity
GM182_04630	COG0617	tRNA 3'-terminal CCA addition
GM182_04630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GM182_04640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GM182_04645	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GM182_04650	COG1051	belongs to the nudix hydrolase family
GM182_04655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GM182_04665	COG1013	pyruvate-flavodoxin oxidoreductase activity
GM182_04690	COG3426	butyrate kinase activity
GM182_04695	COG0497	DNA recombination
GM182_04700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GM182_04705	COG1254	Belongs to the acylphosphatase family
GM182_04710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GM182_04720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GM182_04725	COG0006	proline dipeptidase activity
GM182_04750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GM182_04755	COG1459	type II secretion system
GM182_04765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GM182_04780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GM182_04785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GM182_04790	COG0628	permease
GM182_04795	COG1191	sigma factor activity
GM182_04815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GM182_04820	COG0124	histidyl-tRNA synthetase
GM182_04825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GM182_04830	COG0193	aminoacyl-tRNA hydrolase activity
GM182_04835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GM182_04840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GM182_04845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GM182_04850	COG0717	Belongs to the dCTP deaminase family
GM182_04855	COG1335	isochorismatase
GM182_04860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GM182_04860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GM182_04880	COG0793	Belongs to the peptidase S41A family
GM182_04895	COG2884	Cell division ATP-binding protein ftsE
GM182_04900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GM182_04905	COG0653	protein targeting
GM182_04925	COG0495	leucyl-tRNA aminoacylation
GM182_04930	COG0305	Participates in initiation and elongation during chromosome replication
GM182_04935	COG0359	binds to the 23S rRNA
GM182_04940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GM182_04945	COG0629	single-stranded DNA binding
GM182_04950	COG0360	Binds together with S18 to 16S ribosomal RNA
GM182_04970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GM182_04985	COG0799	negative regulation of ribosome biogenesis
GM182_04990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GM182_04995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GM182_05010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GM182_05015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GM182_05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GM182_05025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GM182_05030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GM182_05045	COG0303	'Molybdopterin
GM182_05050	COG1910	domain protein
GM182_05070	COG0521	Mo-molybdopterin cofactor biosynthetic process
GM182_05070	COG0315	cyclic pyranopterin monophosphate synthase activity
GM182_05075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GM182_05090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GM182_05095	COG0481	GTPase activity
GM182_05100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GM182_05135	COG0728	peptidoglycan biosynthetic process
GM182_05140	COG1744	ABC transporter substrate-binding protein PnrA-like
GM182_05145	COG3845	ABC transporter
GM182_05150	COG4603	Belongs to the binding-protein-dependent transport system permease family
GM182_05155	COG1079	Belongs to the binding-protein-dependent transport system permease family
GM182_05165	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GM182_05180	COG0174	glutamine synthetase
GM182_05195	COG4608	Belongs to the ABC transporter superfamily
GM182_05200	COG0444	Belongs to the ABC transporter superfamily
GM182_05205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GM182_05210	COG0601	transmembrane transport
GM182_05215	COG4166	transmembrane transport
GM182_05230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM182_05235	COG1438	arginine binding
GM182_05245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GM182_05270	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GM182_05275	COG0438	transferase activity, transferring glycosyl groups
GM182_05285	COG1131	(ABC) transporter
GM182_05295	COG4555	ABC transporter
GM182_05305	COG3437	response regulator, receiver
GM182_05305	COG0784	Response regulator, receiver
GM182_05310	COG4191	Histidine kinase
GM182_05320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GM182_05325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GM182_05335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GM182_05340	COG1122	ATPase activity
GM182_05345	COG1122	ATPase activity
GM182_05350	COG0203	ribosomal protein L17
GM182_05355	COG0202	RNA polymerase activity
GM182_05360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GM182_05365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GM182_05370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GM182_05380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GM182_05390	COG0024	Methionine aminopeptidase
GM182_05395	COG0563	adenylate kinase activity
GM182_05405	COG0200	Binds to the 23S rRNA
GM182_05410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GM182_05415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GM182_05420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GM182_05425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GM182_05430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GM182_05435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GM182_05440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GM182_05445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GM182_05450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GM182_05455	COG0255	Belongs to the universal ribosomal protein uL29 family
GM182_05460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GM182_05465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GM182_05470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GM182_05475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GM182_05480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GM182_05485	COG0089	rRNA binding
GM182_05490	COG0088	Forms part of the polypeptide exit tunnel
GM182_05495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GM182_05500	COG0051	transcription antitermination factor activity, RNA binding
GM182_05505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GM182_05510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GM182_05515	COG0049	tRNA binding
GM182_05520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GM182_05545	COG1525	nuclease
GM182_05565	COG3404	Formiminotransferase-cyclodeaminase
GM182_05575	COG0739	heme binding
GM182_05590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GM182_05600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GM182_05605	COG1799	cell septum assembly
GM182_05615	COG1774	PSP1 C-terminal conserved region
GM182_05620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GM182_05630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GM182_05635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GM182_05640	COG0590	tRNA wobble adenosine to inosine editing
GM182_05650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GM182_05655	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GM182_05665	COG1256	bacterial-type flagellum assembly
GM182_05665	COG4786	Flagellar basal body rod
GM182_05685	COG4786	Flagellar basal body rod
GM182_05690	COG4786	Flagellar basal body rod
GM182_05710	COG1191	sigma factor activity
GM182_05720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GM182_05730	COG0643	Histidine kinase
GM182_05730	COG2198	Histidine kinase
GM182_05735	COG0835	chemotaxis
GM182_05750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GM182_05755	COG0515	serine threonine protein kinase
GM182_05755	COG2815	serine threonine protein kinase
GM182_05765	COG2890	protein-(glutamine-N5) methyltransferase activity
GM182_05770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GM182_05775	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GM182_05780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GM182_05785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GM182_05790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GM182_05795	COG0509	glycine decarboxylation via glycine cleavage system
GM182_05800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GM182_05810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GM182_05820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GM182_05825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GM182_05845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GM182_05845	COG1918	ferrous iron import across plasma membrane
GM182_05855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GM182_05865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GM182_05870	COG0196	riboflavin kinase activity
GM182_05875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GM182_05890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GM182_05900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GM182_05905	COG0195	Participates in both transcription termination and antitermination
GM182_05910	COG0779	Required for maturation of 30S ribosomal subunits
GM182_05915	COG0222	ribosome binding
GM182_05920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GM182_05925	COG0081	regulation of translation
GM182_05930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GM182_05950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GM182_05955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GM182_05985	COG2078	PFAM AMMECR1 domain protein
GM182_05985	COG3885	ferrous iron binding
GM182_05995	COG0459	protein refolding
GM182_06000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GM182_06015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GM182_06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GM182_06040	COG0433	COG0433 Predicted ATPase
GM182_06055	COG2342	PFAM TM1410 hypothetical-related protein
GM182_06070	COG1361	Conserved repeat domain
GM182_06070	COG2911	Protein conserved in bacteria
GM182_06070	COG3266	domain, Protein
GM182_06075	COG0534	Mate efflux family protein
GM182_06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GM182_06090	COG4166	transmembrane transport
GM182_06110	COG0746	molybdenum cofactor guanylyltransferase activity
GM182_06115	COG2116	formate transmembrane transporter activity
GM182_06120	COG3383	formate dehydrogenase (NAD+) activity
GM182_06135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GM182_06140	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GM182_06150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GM182_06155	COG0745	RESPONSE REGULATOR receiver
GM182_06160	COG2205	protein histidine kinase activity
GM182_06170	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
GM182_06175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GM182_06185	COG0793	Belongs to the peptidase S41A family
GM182_06195	COG0483	inositol monophosphate 1-phosphatase activity
GM182_06200	COG1295	ribonuclease BN
GM182_06215	COG0733	neurotransmitter:sodium symporter activity
GM182_06220	COG0058	SHG alpha-glucan phosphorylase activity
GM182_06235	COG0017	Asparaginyl-tRNA synthetase
GM182_06250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GM182_06255	COG1162	GTPase activity
GM182_06265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GM182_06275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GM182_06280	COG0242	peptide deformylase activity
GM182_06290	COG3852	Histidine kinase
GM182_06300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GM182_06310	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GM182_06310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GM182_06325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GM182_06335	COG1193	negative regulation of DNA recombination
GM182_06340	COG0072	phenylalanine-tRNA ligase activity
GM182_06345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GM182_06350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GM182_06355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GM182_06360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GM182_06365	COG2165	general secretion pathway protein
GM182_06375	COG1454	alcohol dehydrogenase
GM182_06380	COG3437	response regulator, receiver
GM182_06395	COG0768	penicillin binding
GM182_06405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GM182_06415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GM182_06420	COG1993	acr, cog1993
GM182_06425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GM182_06430	COG0157	Belongs to the NadC ModD family
GM182_06435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GM182_06445	COG0301	tRNA thio-modification
GM182_06455	COG2271	Major facilitator Superfamily
GM182_06460	COG2414	aldehyde ferredoxin oxidoreductase
GM182_06505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GM182_06520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GM182_06520	COG0493	'glutamate synthase
GM182_06525	COG0543	2 iron, 2 sulfur cluster binding
GM182_06545	COG0612	Peptidase, M16
GM182_06550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GM182_06555	COG3956	TIGRFAM MazG family protein
GM182_06560	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GM182_06565	COG0776	regulation of translation
GM182_06580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GM182_06585	COG0009	L-threonylcarbamoyladenylate synthase
GM182_06595	COG0191	fructose-bisphosphate aldolase activity
GM182_06605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GM182_06615	COG1110	DNA topoisomerase II activity
GM182_06620	COG1110	DNA topoisomerase II activity
GM182_06625	COG1592	Rubrerythrin
GM182_06665	COG1489	DNA binding
GM182_06670	COG2252	PERMEase
GM182_06680	COG0243	molybdopterin cofactor binding
GM182_06690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GM182_06695	COG1881	PFAM PEBP family protein
GM182_06705	COG2070	2-Nitropropane dioxygenase
GM182_06710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GM182_06720	COG1595	DNA-templated transcription, initiation
GM182_06725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GM182_06730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GM182_06735	COG1028	Short-chain dehydrogenase reductase Sdr
GM182_06740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GM182_06750	COG1187	pseudouridine synthase activity
GM182_06770	COG0156	8-amino-7-oxononanoate synthase activity
GM182_06795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GM182_06830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GM182_06835	COG1515	deoxyribonuclease V activity
GM182_06855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GM182_06860	COG1480	7TM receptor with intracellular HD hydrolase
GM182_06865	COG1702	phosphate starvation-inducible protein PhoH
GM182_06875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GM182_06875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GM182_06885	COG2359	stage V sporulation protein S
GM182_06895	COG0840	transmembrane signaling receptor activity
GM182_06900	COG0731	radical SAM domain protein
GM182_06900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GM182_06910	COG0489	protein tyrosine kinase activity
GM182_06935	COG1404	Belongs to the peptidase S8 family
GM182_06940	COG0840	transmembrane signaling receptor activity
GM182_06945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GM182_06970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GM182_06975	COG0297	glycogen (starch) synthase activity
GM182_06980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GM182_06985	COG1278	Cold shock
GM182_07000	COG1309	transcriptional regulator
GM182_07005	COG2033	superoxide reductase activity
GM182_07010	COG0450	alkyl hydroperoxide reductase
GM182_07015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GM182_07080	COG3848	Pyruvate phosphate dikinase
GM182_07080	COG0574	Belongs to the PEP-utilizing enzyme family
GM182_07095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GM182_07100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GM182_07105	COG0298	carbon dioxide binding
GM182_07120	COG0375	protein maturation
GM182_07125	COG0310	cobalt ion transport
GM182_07160	COG3260	NADH ubiquinone oxidoreductase 20
GM182_07170	COG0651	ATP synthesis coupled electron transport
GM182_07175	COG1006	Multisubunit Na H antiporter MnhC subunit
GM182_07215	COG0649	NAD binding
GM182_07215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GM182_07230	COG0668	transmembrane transport
GM182_07275	COG0572	uridine kinase
GM182_07320	COG1730	sister chromatid segregation
GM182_07345	COG0668	transmembrane transport
GM182_07350	COG3266	domain, Protein
GM182_07350	COG2911	Protein conserved in bacteria
GM182_07350	COG1361	Conserved repeat domain
GM182_07355	COG0733	neurotransmitter:sodium symporter activity
GM182_07375	COG1307	EDD domain protein, DegV family
GM182_07385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GM182_07415	COG1811	Na channel or pump
GM182_07430	COG1401	restriction endodeoxyribonuclease activity
GM182_07455	COG1794	racemase activity, acting on amino acids and derivatives
GM182_07465	COG0697	spore germination
GM182_07485	COG0393	Putative heavy-metal-binding
GM182_07510	COG1715	Restriction endonuclease
GM182_07540	COG3266	domain, Protein
GM182_07540	COG2911	Protein conserved in bacteria
GM182_07540	COG1361	Conserved repeat domain
GM182_07590	COG3437	response regulator, receiver
GM182_07595	COG3437	response regulator, receiver
GM182_07600	COG3437	response regulator, receiver
GM182_07605	COG0540	Belongs to the ATCase OTCase family
GM182_07610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GM182_07615	COG0543	2 iron, 2 sulfur cluster binding
GM182_07620	COG0167	dihydroorotate dehydrogenase activity
GM182_07625	COG0284	orotidine-5'-phosphate decarboxylase activity
GM182_07630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GM182_07690	COG3706	GGDEF domain
GM182_07695	COG0517	IMP dehydrogenase activity
GM182_07695	COG1227	inorganic diphosphatase activity
GM182_07725	COG1404	Belongs to the peptidase S8 family
GM182_07750	COG1361	Conserved repeat domain
GM182_07755	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GM182_07765	COG0312	modulator of DNA gyrase
GM182_07770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)