locus-tag	class	description
IPG37_00005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPG37_00020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IPG37_00040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPG37_00055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPG37_00070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPG37_00075	COG0343	queuine tRNA-ribosyltransferase activity
IPG37_00115	COG0768	penicillin binding
IPG37_00130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IPG37_00135	COG4589	Belongs to the CDS family
IPG37_00140	COG0792	nuclease activity
IPG37_00155	COG1278	Cold shock
IPG37_00170	COG1132	(ABC) transporter
IPG37_00185	COG0670	Belongs to the BI1 family
IPG37_00210	COG0339	signal peptide processing
IPG37_00230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IPG37_00235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPG37_00260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPG37_00265	COG1040	competence protein
IPG37_00270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPG37_00295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPG37_00320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPG37_00335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPG37_00370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPG37_00375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPG37_00390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPG37_00400	COG1193	negative regulation of DNA recombination
IPG37_00425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPG37_00440	COG0250	Participates in transcription elongation, termination and antitermination
IPG37_00450	COG0081	regulation of translation
IPG37_00455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPG37_00460	COG0222	ribosome binding
IPG37_00465	COG0085	RNA polymerase activity
IPG37_00470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPG37_00485	COG1185	polyribonucleotide nucleotidyltransferase activity
IPG37_00490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPG37_00540	COG0210	DNA helicase
IPG37_00545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPG37_00560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPG37_00565	COG0228	four-way junction DNA binding
IPG37_00575	COG4752	Belongs to the RNA methyltransferase TrmD family
IPG37_00575	COG0336	Belongs to the RNA methyltransferase TrmD family
IPG37_00615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPG37_00620	COG0416	fatty acid biosynthetic process
IPG37_00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPG37_00635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPG37_00640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPG37_00665	COG1674	ftsk spoiiie
IPG37_00670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPG37_00675	COG0275	rRNA processing
IPG37_00685	COG2088	sporulation resulting in formation of a cellular spore
IPG37_00695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPG37_00760	COG0803	Belongs to the bacterial solute-binding protein 9 family
IPG37_00765	COG1121	(ABC) transporter
IPG37_00770	COG1321	iron dependent repressor
IPG37_00770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPG37_00775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPG37_00785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPG37_00785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPG37_00800	COG1054	Belongs to the UPF0176 family
IPG37_00805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPG37_00850	COG0357	Ribosomal RNA small subunit methyltransferase G
IPG37_00870	COG0154	amidase activity
IPG37_00915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPG37_00990	COG0166	Belongs to the GPI family
IPG37_00995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPG37_01000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPG37_01000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPG37_01010	COG3876	Protein conserved in bacteria
IPG37_01035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPG37_01065	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPG37_01085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPG37_01090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPG37_01175	COG1177	transmembrane transport
IPG37_01180	COG1176	ABC-type spermidine putrescine transport system, permease component I
IPG37_01185	COG3842	ATPase activity
IPG37_01200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPG37_01215	COG0424	maF-like protein
IPG37_01330	COG0629	single-stranded DNA binding
IPG37_01365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPG37_01385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPG37_01390	COG3202	ADP transmembrane transporter activity
IPG37_01400	COG0052	Belongs to the universal ribosomal protein uS2 family
IPG37_01420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPG37_01425	COG1160	GTP binding
IPG37_01455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IPG37_01465	COG2255	four-way junction helicase activity
IPG37_01470	COG0772	Belongs to the SEDS family
IPG37_01495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPG37_01505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPG37_01510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPG37_01550	COG0492	ferredoxin-NADP+ reductase activity
IPG37_01570	COG0233	cytoplasmic translational termination
IPG37_01595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPG37_01605	COG0569	domain protein
IPG37_01610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IPG37_01615	COG0423	glycine-tRNA ligase activity
IPG37_01620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG37_01705	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPG37_01710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPG37_01725	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPG37_01740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG37_01755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPG37_01780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPG37_01815	COG1187	pseudouridine synthase activity
IPG37_01820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPG37_01855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG37_01875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPG37_01890	COG0617	tRNA 3'-terminal CCA addition
IPG37_01925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG37_01930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPG37_01935	COG0268	Binds directly to 16S ribosomal RNA
IPG37_01950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IPG37_01965	COG0772	Belongs to the SEDS family
IPG37_01970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPG37_01980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPG37_02020	COG0359	binds to the 23S rRNA
IPG37_02030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPG37_02040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPG37_02160	COG3335	DDE superfamily endonuclease
IPG37_02170	COG0463	Glycosyl transferase, family 2
IPG37_02170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IPG37_02185	COG0442	prolyl-tRNA aminoacylation
IPG37_02215	COG1692	metallophosphoesterase
IPG37_02220	COG1418	mRNA catabolic process
IPG37_02240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPG37_02245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPG37_02250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPG37_02280	COG0443	Heat shock 70 kDa protein
IPG37_02290	COG0012	GTP binding
IPG37_02345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPG37_02355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPG37_02360	COG0768	penicillin binding
IPG37_02375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPG37_02450	COG1561	YicC-like family, N-terminal region
IPG37_02455	COG0217	transcriptional regulatory protein
IPG37_02470	COG0481	GTPase activity
IPG37_02545	COG0793	Belongs to the peptidase S41A family
IPG37_02560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPG37_02565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPG37_02565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPG37_02570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPG37_02590	COG1793	dna ligase
IPG37_02605	COG0084	hydrolase, TatD family'
IPG37_02615	COG2385	sporulation resulting in formation of a cellular spore
IPG37_02620	COG0328	RNA-DNA hybrid ribonuclease activity
IPG37_02635	COG0783	Belongs to the Dps family
IPG37_02645	COG1114	Component of the transport system for branched-chain amino acids
IPG37_02670	COG0419	ATPase involved in DNA repair
IPG37_02675	COG0419	ATPase involved in DNA repair
IPG37_02705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPG37_02775	COG1388	LysM domain
IPG37_02775	COG4942	peptidase
IPG37_02780	COG0681	Belongs to the peptidase S26 family
IPG37_02790	COG1132	(ABC) transporter
IPG37_02875	COG0037	tRNA processing
IPG37_02890	COG0187	DNA topoisomerase II activity
IPG37_02900	COG0590	tRNA wobble adenosine to inosine editing
IPG37_02915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPG37_02920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPG37_02960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IPG37_02975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPG37_02995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPG37_03010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPG37_03015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPG37_03025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG37_03070	COG0706	membrane insertase activity
IPG37_03075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPG37_03080	COG0006	proline dipeptidase activity
IPG37_03105	COG0758	DNA mediated transformation
IPG37_03115	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPG37_03130	COG0484	heat shock protein binding
IPG37_03175	COG0719	Fe-S assembly protein
IPG37_03185	COG0396	ATPase activity
IPG37_03200	COG0203	ribosomal protein L17
IPG37_03205	COG0202	RNA polymerase activity
IPG37_03210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPG37_03215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPG37_03220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPG37_03225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPG37_03240	COG0201	protein transport
IPG37_03245	COG0200	Binds to the 23S rRNA
IPG37_03250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPG37_03255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPG37_03260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPG37_03265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPG37_03270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPG37_03275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPG37_03280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPG37_03285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPG37_03290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPG37_03295	COG0255	Belongs to the universal ribosomal protein uL29 family
IPG37_03300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPG37_03305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPG37_03310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPG37_03315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPG37_03320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPG37_03325	COG0089	rRNA binding
IPG37_03330	COG0088	Forms part of the polypeptide exit tunnel
IPG37_03335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPG37_03340	COG0051	transcription antitermination factor activity, RNA binding
IPG37_03345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPG37_03350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPG37_03355	COG0049	tRNA binding
IPG37_03360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPG37_03365	COG0750	zinc metalloprotease
IPG37_03375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPG37_03380	COG1757	Na H antiporter
IPG37_03395	COG3896	Chloramphenicol phosphotransferase-like protein
IPG37_03415	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPG37_03480	COG1115	amino acid carrier protein
IPG37_03485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPG37_03525	COG0495	leucyl-tRNA aminoacylation
IPG37_03545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPG37_03575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPG37_03580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPG37_03630	COG0606	chelatase, subunit chli
IPG37_03640	COG0736	holo-[acyl-carrier-protein] synthase activity
IPG37_03675	COG0714	Associated with various cellular activities
IPG37_03700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPG37_03715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPG37_03730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPG37_03750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPG37_03775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPG37_03795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPG37_03845	COG0415	Belongs to the DNA photolyase family
IPG37_03860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPG37_03865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPG37_03895	COG3118	belongs to the thioredoxin family
IPG37_03940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPG37_03950	COG0318	PFAM AMP-dependent synthetase and ligase
IPG37_03965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPG37_03970	COG1136	(ABC) transporter
IPG37_03975	COG0728	peptidoglycan biosynthetic process
IPG37_03980	COG1051	belongs to the nudix hydrolase family
IPG37_04010	COG2382	esterase
IPG37_04010	COG3693	PFAM glycoside hydrolase, family 10
IPG37_04030	COG0697	spore germination
IPG37_04070	COG0564	pseudouridine synthase activity
IPG37_04075	COG2239	Acts as a magnesium transporter
IPG37_04100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPG37_04105	COG0459	protein refolding
IPG37_04130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPG37_04170	COG1530	ribonuclease E activity
IPG37_04180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPG37_04185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPG37_04200	COG0632	four-way junction helicase activity
IPG37_04220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPG37_04235	COG4112	unkown
IPG37_04245	COG0101	tRNA pseudouridine synthase activity
IPG37_04250	COG1217	gtp-binding protein TYPA
IPG37_04255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPG37_04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPG37_04325	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPG37_04330	COG1459	type II secretion system
IPG37_04360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPG37_04365	COG1216	Glycosyl transferase, family 2
IPG37_04390	COG0488	(ABC) transporter
IPG37_04410	COG2723	6-phospho-beta-galactosidase activity
IPG37_04415	COG0552	protein localization to endoplasmic reticulum
IPG37_04420	COG2890	protein-(glutamine-N5) methyltransferase activity
IPG37_04435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPG37_04445	COG0193	aminoacyl-tRNA hydrolase activity
IPG37_04465	COG4133	protoheme IX ABC transporter activity
IPG37_04495	COG1872	DUF167
IPG37_04510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPG37_04515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPG37_04515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPG37_04620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPG37_04630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IPG37_04700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPG37_04720	COG0789	Transcriptional regulator
IPG37_04770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPG37_04785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPG37_04820	COG0612	Peptidase, M16
IPG37_04835	COG1573	uracil-dna glycosylase
IPG37_04840	COG0195	Participates in both transcription termination and antitermination
IPG37_04840	COG2251	uridine kinase activity
IPG37_04845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPG37_04855	COG0653	protein targeting
IPG37_04870	COG1253	flavin adenine dinucleotide binding
IPG37_04880	COG0358	DNA primase activity
IPG37_04920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPG37_04970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPG37_04985	COG0215	cysteine-tRNA ligase activity
IPG37_05010	COG1793	dna ligase
IPG37_05010	COG3285	dna ligase
IPG37_05020	COG0556	nucleotide-excision repair
IPG37_05055	COG2183	response to ionizing radiation
IPG37_05055	COG0539	negative regulation of cytoplasmic translation
IPG37_05065	COG0124	histidyl-tRNA synthetase
IPG37_05095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPG37_05100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPG37_05110	COG0445	tRNA wobble uridine modification
IPG37_05115	COG0322	excinuclease ABC activity
IPG37_05130	COG0542	response to heat
IPG37_05145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPG37_05150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPG37_05155	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation