locus-tag	class	description
IPH25_00045	COG3335	DDE superfamily endonuclease
IPH25_00055	COG0463	Glycosyl transferase, family 2
IPH25_00055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IPH25_00070	COG0442	prolyl-tRNA aminoacylation
IPH25_00100	COG1692	metallophosphoesterase
IPH25_00105	COG1418	mRNA catabolic process
IPH25_00125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPH25_00130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPH25_00135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPH25_00165	COG0443	Heat shock 70 kDa protein
IPH25_00175	COG0012	GTP binding
IPH25_00230	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPH25_00240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPH25_00245	COG0768	penicillin binding
IPH25_00260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPH25_00335	COG1561	YicC-like family, N-terminal region
IPH25_00340	COG0217	transcriptional regulatory protein
IPH25_00355	COG0481	GTPase activity
IPH25_00430	COG0793	Belongs to the peptidase S41A family
IPH25_00445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPH25_00450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPH25_00450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPH25_00455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPH25_00475	COG1793	dna ligase
IPH25_00490	COG0084	hydrolase, TatD family'
IPH25_00500	COG2385	sporulation resulting in formation of a cellular spore
IPH25_00505	COG0328	RNA-DNA hybrid ribonuclease activity
IPH25_00520	COG0783	Belongs to the Dps family
IPH25_00530	COG1114	Component of the transport system for branched-chain amino acids
IPH25_00555	COG0419	ATPase involved in DNA repair
IPH25_00585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPH25_00655	COG4942	peptidase
IPH25_00655	COG1388	LysM domain
IPH25_00660	COG0681	Belongs to the peptidase S26 family
IPH25_00670	COG1132	(ABC) transporter
IPH25_00755	COG0037	tRNA processing
IPH25_00780	COG0590	tRNA wobble adenosine to inosine editing
IPH25_00795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPH25_00800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPH25_00840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IPH25_00855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPH25_00875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPH25_00890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPH25_00895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPH25_00905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPH25_00950	COG0706	membrane insertase activity
IPH25_00955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPH25_00960	COG0006	proline dipeptidase activity
IPH25_00980	COG0758	DNA mediated transformation
IPH25_00990	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPH25_01005	COG0484	heat shock protein binding
IPH25_01050	COG0719	Fe-S assembly protein
IPH25_01060	COG0396	ATPase activity
IPH25_01075	COG0203	ribosomal protein L17
IPH25_01080	COG0202	RNA polymerase activity
IPH25_01085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPH25_01090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPH25_01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPH25_01100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPH25_01115	COG0201	protein transport
IPH25_01120	COG0200	Binds to the 23S rRNA
IPH25_01125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPH25_01130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPH25_01135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPH25_01140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPH25_01145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPH25_01150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPH25_01155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPH25_01160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPH25_01165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPH25_01170	COG0255	Belongs to the universal ribosomal protein uL29 family
IPH25_01175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPH25_01180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPH25_01185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPH25_01190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPH25_01195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPH25_01200	COG0089	rRNA binding
IPH25_01205	COG0088	Forms part of the polypeptide exit tunnel
IPH25_01210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPH25_01215	COG0051	transcription antitermination factor activity, RNA binding
IPH25_01220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPH25_01225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPH25_01230	COG0049	tRNA binding
IPH25_01235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPH25_01240	COG0750	zinc metalloprotease
IPH25_01250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPH25_01255	COG1757	Na H antiporter
IPH25_01270	COG3896	Chloramphenicol phosphotransferase-like protein
IPH25_01290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPH25_01355	COG1115	amino acid carrier protein
IPH25_01360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPH25_01400	COG0495	leucyl-tRNA aminoacylation
IPH25_01420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPH25_01450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPH25_01455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPH25_01500	COG0606	chelatase, subunit chli
IPH25_01510	COG0736	holo-[acyl-carrier-protein] synthase activity
IPH25_01545	COG0714	Associated with various cellular activities
IPH25_01570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPH25_01585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPH25_01600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPH25_01620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPH25_01645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPH25_01665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPH25_01715	COG0415	Belongs to the DNA photolyase family
IPH25_01730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPH25_01735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPH25_01765	COG3118	belongs to the thioredoxin family
IPH25_01810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPH25_01820	COG0318	PFAM AMP-dependent synthetase and ligase
IPH25_01835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPH25_01840	COG1136	(ABC) transporter
IPH25_01845	COG0728	peptidoglycan biosynthetic process
IPH25_01850	COG1051	belongs to the nudix hydrolase family
IPH25_01880	COG2382	esterase
IPH25_01880	COG3693	PFAM glycoside hydrolase, family 10
IPH25_01900	COG0697	spore germination
IPH25_01940	COG0564	pseudouridine synthase activity
IPH25_01945	COG2239	Acts as a magnesium transporter
IPH25_01970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPH25_01975	COG0459	protein refolding
IPH25_02000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPH25_02040	COG1530	ribonuclease E activity
IPH25_02050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPH25_02055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPH25_02070	COG0632	four-way junction helicase activity
IPH25_02090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPH25_02105	COG4112	unkown
IPH25_02115	COG0101	tRNA pseudouridine synthase activity
IPH25_02120	COG1217	gtp-binding protein TYPA
IPH25_02125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPH25_02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPH25_02190	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPH25_02195	COG1459	type II secretion system
IPH25_02220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPH25_02225	COG1216	Glycosyl transferase, family 2
IPH25_02250	COG0488	(ABC) transporter
IPH25_02270	COG2723	6-phospho-beta-galactosidase activity
IPH25_02275	COG0552	protein localization to endoplasmic reticulum
IPH25_02280	COG2890	protein-(glutamine-N5) methyltransferase activity
IPH25_02295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPH25_02305	COG0193	aminoacyl-tRNA hydrolase activity
IPH25_02325	COG4133	protoheme IX ABC transporter activity
IPH25_02355	COG1872	DUF167
IPH25_02370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPH25_02375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPH25_02375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPH25_02480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPH25_02490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IPH25_02560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPH25_02580	COG0789	Transcriptional regulator
IPH25_02630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPH25_02645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPH25_02680	COG0612	Peptidase, M16
IPH25_02695	COG1573	uracil-dna glycosylase
IPH25_02700	COG2251	uridine kinase activity
IPH25_02700	COG0195	Participates in both transcription termination and antitermination
IPH25_02705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPH25_02715	COG0653	protein targeting
IPH25_02730	COG1253	flavin adenine dinucleotide binding
IPH25_02740	COG0358	DNA primase activity
IPH25_02780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPH25_02830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPH25_02845	COG0215	cysteine-tRNA ligase activity
IPH25_02870	COG3285	dna ligase
IPH25_02870	COG1793	dna ligase
IPH25_02880	COG0556	nucleotide-excision repair
IPH25_02915	COG2183	response to ionizing radiation
IPH25_02915	COG0539	negative regulation of cytoplasmic translation
IPH25_02925	COG0124	histidyl-tRNA synthetase
IPH25_02955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPH25_02960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPH25_02970	COG0445	tRNA wobble uridine modification
IPH25_02975	COG0322	excinuclease ABC activity
IPH25_02990	COG0542	response to heat
IPH25_03005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPH25_03010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPH25_03015	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IPH25_03020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPH25_03030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IPH25_03050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPH25_03065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPH25_03080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPH25_03085	COG0343	queuine tRNA-ribosyltransferase activity
IPH25_03125	COG0768	penicillin binding
IPH25_03140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IPH25_03145	COG4589	Belongs to the CDS family
IPH25_03150	COG0792	nuclease activity
IPH25_03165	COG1278	Cold shock
IPH25_03180	COG1132	(ABC) transporter
IPH25_03195	COG0670	Belongs to the BI1 family
IPH25_03220	COG0339	signal peptide processing
IPH25_03240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IPH25_03245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPH25_03270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPH25_03275	COG1040	competence protein
IPH25_03280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPH25_03305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPH25_03330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPH25_03345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPH25_03380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPH25_03385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPH25_03400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPH25_03410	COG1193	negative regulation of DNA recombination
IPH25_03435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPH25_03450	COG0250	Participates in transcription elongation, termination and antitermination
IPH25_03460	COG0081	regulation of translation
IPH25_03465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPH25_03470	COG0222	ribosome binding
IPH25_03475	COG0085	RNA polymerase activity
IPH25_03480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPH25_03495	COG1185	polyribonucleotide nucleotidyltransferase activity
IPH25_03500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPH25_03550	COG0210	DNA helicase
IPH25_03555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPH25_03570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPH25_03575	COG0228	four-way junction DNA binding
IPH25_03585	COG0336	Belongs to the RNA methyltransferase TrmD family
IPH25_03585	COG4752	Belongs to the RNA methyltransferase TrmD family
IPH25_03620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPH25_03625	COG0416	fatty acid biosynthetic process
IPH25_03635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPH25_03640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPH25_03645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPH25_03670	COG1674	ftsk spoiiie
IPH25_03675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPH25_03680	COG0275	rRNA processing
IPH25_03690	COG2088	sporulation resulting in formation of a cellular spore
IPH25_03700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPH25_03765	COG0803	Belongs to the bacterial solute-binding protein 9 family
IPH25_03770	COG1121	(ABC) transporter
IPH25_03775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPH25_03775	COG1321	iron dependent repressor
IPH25_03780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPH25_03790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPH25_03790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPH25_03805	COG1054	Belongs to the UPF0176 family
IPH25_03810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPH25_03855	COG0357	Ribosomal RNA small subunit methyltransferase G
IPH25_03875	COG0154	amidase activity
IPH25_03920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPH25_03995	COG0166	Belongs to the GPI family
IPH25_04000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPH25_04005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPH25_04005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPH25_04015	COG3876	Protein conserved in bacteria
IPH25_04040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPH25_04070	COG4968	Prepilin-type N-terminal cleavage methylation domain
IPH25_04090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPH25_04095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPH25_04180	COG1177	transmembrane transport
IPH25_04190	COG3842	ATPase activity
IPH25_04205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPH25_04220	COG0424	maF-like protein
IPH25_04335	COG0629	single-stranded DNA binding
IPH25_04370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPH25_04390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPH25_04395	COG3202	ADP transmembrane transporter activity
IPH25_04405	COG0052	Belongs to the universal ribosomal protein uS2 family
IPH25_04425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPH25_04430	COG1160	GTP binding
IPH25_04460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IPH25_04470	COG2255	four-way junction helicase activity
IPH25_04475	COG0772	Belongs to the SEDS family
IPH25_04500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPH25_04510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPH25_04515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPH25_04555	COG0492	ferredoxin-NADP+ reductase activity
IPH25_04575	COG0233	cytoplasmic translational termination
IPH25_04600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPH25_04610	COG0569	domain protein
IPH25_04615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IPH25_04620	COG0423	glycine-tRNA ligase activity
IPH25_04625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPH25_04710	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPH25_04715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPH25_04730	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPH25_04745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPH25_04760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPH25_04785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPH25_04815	COG1187	pseudouridine synthase activity
IPH25_04820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPH25_04850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPH25_04870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPH25_04885	COG0617	tRNA 3'-terminal CCA addition
IPH25_04920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPH25_04925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPH25_04930	COG0268	Binds directly to 16S ribosomal RNA
IPH25_04945	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IPH25_04960	COG0772	Belongs to the SEDS family
IPH25_04965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPH25_04975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPH25_05015	COG0359	binds to the 23S rRNA
IPH25_05025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPH25_05035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP