locus-tag	class	description
IPM19_00075	COG0525	valine-tRNA ligase activity
IPM19_00090	COG2165	general secretion pathway protein
IPM19_00100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM19_00105	COG2155	Conserved Protein
IPM19_00150	COG2514	catechol 2,3-dioxygenase activity
IPM19_00165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPM19_00170	COG0475	glutathione-regulated potassium exporter activity
IPM19_00180	COG3655	Transcriptional regulator
IPM19_00190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPM19_00205	COG1937	Protein conserved in bacteria
IPM19_00225	COG3634	alkyl hydroperoxide reductase activity
IPM19_00235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPM19_00240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPM19_00250	COG0360	Binds together with S18 to 16S ribosomal RNA
IPM19_00255	COG0012	GTP binding
IPM19_00290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPM19_00295	COG0346	lactoylglutathione lyase activity
IPM19_00325	COG0322	excinuclease ABC activity
IPM19_00355	COG1420	regulation of RNA biosynthetic process
IPM19_00360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM19_00380	COG0484	heat shock protein binding
IPM19_00390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IPM19_00420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPM19_00435	COG0758	DNA mediated transformation
IPM19_00435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM19_00460	COG1160	GTP binding
IPM19_00475	COG0124	histidyl-tRNA synthetase
IPM19_00480	COG0537	adenosine 5'-monophosphoramidase activity
IPM19_00500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPM19_00515	COG0124	histidyl-tRNA synthetase
IPM19_00525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPM19_00540	COG0483	inositol monophosphate 1-phosphatase activity
IPM19_00545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPM19_00565	COG2226	methyltransferase
IPM19_00580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPM19_00590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPM19_00605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPM19_00615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM19_00625	COG0776	regulation of translation
IPM19_00670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM19_00675	COG1459	type II secretion system
IPM19_00705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM19_00725	COG1217	gtp-binding protein TYPA
IPM19_00740	COG0628	permease
IPM19_00750	COG1110	DNA topoisomerase II activity
IPM19_00780	COG0579	oxidoreductase
IPM19_00785	COG0473	3-isopropylmalate dehydrogenase activity
IPM19_00820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPM19_00845	COG0513	Belongs to the DEAD box helicase family
IPM19_00860	COG0277	FAD linked oxidase domain protein
IPM19_00880	COG1132	(ABC) transporter
IPM19_00895	COG1187	pseudouridine synthase activity
IPM19_00945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPM19_00955	COG1185	polyribonucleotide nucleotidyltransferase activity
IPM19_00975	COG0423	glycine-tRNA ligase activity
IPM19_00980	COG0612	Peptidase, M16
IPM19_00985	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IPM19_01005	COG0628	permease
IPM19_01010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM19_01015	COG0084	hydrolase, TatD family'
IPM19_01025	COG0495	leucyl-tRNA aminoacylation
IPM19_01030	COG0662	Cupin 2, conserved barrel domain protein
IPM19_01040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPM19_01045	COG1968	undecaprenyl-diphosphatase activity
IPM19_01060	COG1475	DNA binding
IPM19_01070	COG0756	dUTP diphosphatase activity
IPM19_01110	COG1994	Peptidase M50
IPM19_01120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPM19_01125	COG0049	tRNA binding
IPM19_01130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM19_01180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM19_01205	COG0051	transcription antitermination factor activity, RNA binding
IPM19_01210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPM19_01215	COG0088	Forms part of the polypeptide exit tunnel
IPM19_01220	COG0089	rRNA binding
IPM19_01230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPM19_01240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPM19_01255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPM19_01265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPM19_01270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPM19_01275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPM19_01280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPM19_01285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPM19_01295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPM19_01305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPM19_01310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPM19_01315	COG0200	Binds to the 23S rRNA
IPM19_01370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPM19_01380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPM19_01390	COG0149	triose-phosphate isomerase activity
IPM19_01400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPM19_01405	COG3959	Transketolase, thiamine diphosphate binding domain
IPM19_01415	COG3958	Transketolase
IPM19_01440	COG0126	phosphoglycerate kinase activity
IPM19_01445	COG0148	phosphopyruvate hydratase activity
IPM19_01455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPM19_01460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPM19_01460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPM19_01475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPM19_01480	COG1077	Cell shape determining protein MreB Mrl
IPM19_01495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPM19_01510	COG5002	protein histidine kinase activity
IPM19_01515	COG0745	RESPONSE REGULATOR receiver
IPM19_01535	COG2001	Belongs to the MraZ family
IPM19_01540	COG0275	rRNA processing
IPM19_01550	COG0768	penicillin binding
IPM19_01560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPM19_01575	COG0284	orotidine-5'-phosphate decarboxylase activity
IPM19_01585	COG0277	FAD linked oxidase domain protein
IPM19_01615	COG2133	pyrroloquinoline quinone binding
IPM19_01680	COG0482	sulfurtransferase activity
IPM19_01690	COG0424	maF-like protein
IPM19_01705	COG0604	alcohol dehydrogenase
IPM19_01760	COG0330	HflC and HflK could
IPM19_01775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPM19_01780	COG3695	enzyme binding
IPM19_01885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPM19_01890	COG0222	ribosome binding
IPM19_01895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPM19_01935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM19_01940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM19_01945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPM19_01955	COG1054	Belongs to the UPF0176 family
IPM19_01985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPM19_02000	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPM19_02065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPM19_02075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IPM19_02090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPM19_02105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPM19_02110	COG0305	Participates in initiation and elongation during chromosome replication
IPM19_02115	COG0215	cysteine-tRNA ligase activity
IPM19_02125	COG0563	adenylate kinase activity
IPM19_02130	COG0563	adenylate kinase activity
IPM19_02160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPM19_02175	COG0772	Belongs to the SEDS family
IPM19_02190	COG2890	protein-(glutamine-N5) methyltransferase activity
IPM19_02195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM19_02205	COG0254	rRNA binding
IPM19_02210	COG0052	Belongs to the universal ribosomal protein uS2 family
IPM19_02215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPM19_02230	COG1193	negative regulation of DNA recombination
IPM19_02245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPM19_02295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPM19_02315	COG0438	transferase activity, transferring glycosyl groups
IPM19_02335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM19_02340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPM19_02350	COG0653	protein targeting
IPM19_02360	COG1573	uracil-dna glycosylase
IPM19_02370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM19_02375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM19_02395	COG3118	belongs to the thioredoxin family
IPM19_02400	COG1686	Belongs to the peptidase S11 family
IPM19_02405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM19_02410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IPM19_02415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPM19_02420	COG0772	Belongs to the SEDS family
IPM19_02430	COG0728	peptidoglycan biosynthetic process
IPM19_02435	COG0481	GTPase activity
IPM19_02455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM19_02470	COG0494	nUDIX hydrolase
IPM19_02480	COG0356	it plays a direct role in the translocation of protons across the membrane
IPM19_02490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPM19_02495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM19_02500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPM19_02510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPM19_02515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPM19_02520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPM19_02525	COG0617	tRNA 3'-terminal CCA addition
IPM19_02575	COG0210	DNA helicase
IPM19_02580	COG0586	Pfam SNARE associated Golgi protein
IPM19_02605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPM19_02615	COG0187	DNA topoisomerase II activity
IPM19_02630	COG0250	Participates in transcription elongation, termination and antitermination
IPM19_02635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPM19_02655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPM19_02660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPM19_02665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPM19_02675	COG2884	Cell division ATP-binding protein ftsE
IPM19_02680	COG2177	Part of the ABC transporter FtsEX involved in
IPM19_02685	COG0359	binds to the 23S rRNA
IPM19_02695	COG0504	CTP synthase activity
IPM19_02710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPM19_02725	COG1104	cysteine desulfurase activity
IPM19_02730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPM19_02745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM19_02745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM19_02765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM19_02765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM19_02785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM19_02790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IPM19_02800	COG2340	Cysteine-rich secretory protein family
IPM19_02815	COG0242	peptide deformylase activity
IPM19_02840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM19_02845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM19_02870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM19_02880	COG3340	Belongs to the peptidase S51 family
IPM19_02890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM19_02905	COG0668	transmembrane transport
IPM19_02910	COG0432	Pfam Uncharacterised protein family UPF0047
IPM19_02915	COG5002	protein histidine kinase activity
IPM19_02935	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IPM19_02955	COG0745	RESPONSE REGULATOR receiver
IPM19_02960	COG0776	regulation of translation
IPM19_02970	COG3266	domain, Protein
IPM19_02970	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IPM19_02970	COG4932	domain protein
IPM19_02975	COG1611	Belongs to the LOG family
IPM19_03010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPM19_03015	COG0203	ribosomal protein L17
IPM19_03020	COG0202	RNA polymerase activity
IPM19_03025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPM19_03030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPM19_03035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPM19_03040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPM19_03045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPM19_03075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM19_03085	COG3409	Peptidoglycan-binding domain 1 protein
IPM19_03085	COG0793	Belongs to the peptidase S41A family
IPM19_03095	COG0438	transferase activity, transferring glycosyl groups
IPM19_03125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM19_03150	COG1595	DNA-templated transcription, initiation
IPM19_03185	COG0463	Glycosyl transferase, family 2
IPM19_03210	COG1215	transferase activity, transferring glycosyl groups
IPM19_03235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM19_03270	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM19_03275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM19_03280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM19_03285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPM19_03290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPM19_03305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPM19_03310	COG0768	penicillin binding
IPM19_03325	COG1077	Cell shape determining protein MreB Mrl
IPM19_03330	COG0442	prolyl-tRNA aminoacylation
IPM19_03335	COG0750	zinc metalloprotease
IPM19_03340	COG0233	cytoplasmic translational termination
IPM19_03375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM19_03390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM19_03395	COG1704	LemA family
IPM19_03400	COG0501	Belongs to the peptidase M48B family
IPM19_03415	COG2137	regulation of response to DNA damage stimulus
IPM19_03420	COG0542	response to heat
IPM19_03430	COG1040	competence protein
IPM19_03455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPM19_03485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPM19_03495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPM19_03575	COG0517	IMP dehydrogenase activity
IPM19_03590	COG0517	IMP dehydrogenase activity
IPM19_03590	COG0516	GMP reductase activity
IPM19_03605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM19_03610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM19_03615	COG0018	arginyl-trna synthetase
IPM19_03625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPM19_03700	COG1525	nuclease
IPM19_03705	COG1073	alpha beta
IPM19_03750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPM19_03755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPM19_03760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPM19_03790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPM19_03790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM19_03795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM19_03800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPM19_03860	COG1741	Belongs to the pirin family
IPM19_03875	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IPM19_03965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM19_03965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM19_03970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IPM19_03975	COG1017	nitric oxide dioxygenase activity
IPM19_03975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPM19_03985	COG0745	RESPONSE REGULATOR receiver
IPM19_04005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM19_04015	COG1470	cell adhesion involved in biofilm formation
IPM19_04020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM19_04035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPM19_04040	COG0358	DNA primase activity
IPM19_04070	COG0469	pyruvate kinase activity
IPM19_04075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPM19_04105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM19_04110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM19_04115	COG0791	NLP P60 protein
IPM19_04115	COG1388	LysM domain
IPM19_04140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IPM19_04150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM19_04155	COG0438	transferase activity, transferring glycosyl groups
IPM19_04160	COG0438	transferase activity, transferring glycosyl groups
IPM19_04180	COG2165	general secretion pathway protein
IPM19_04185	COG1459	type II secretion system
IPM19_04190	COG1459	type II secretion system
IPM19_04205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM19_04245	COG2340	Cysteine-rich secretory protein family
IPM19_04260	COG0739	heme binding
IPM19_04260	COG1196	nuclear chromosome segregation
IPM19_04260	COG0741	lytic transglycosylase activity
IPM19_04285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IPM19_04290	COG2176	DNA-directed DNA polymerase activity
IPM19_04300	COG1132	(ABC) transporter
IPM19_04310	COG0740	serine-type endopeptidase activity
IPM19_04315	COG0195	Participates in both transcription termination and antitermination
IPM19_04320	COG0792	nuclease activity
IPM19_04330	COG2226	methyltransferase
IPM19_04335	COG1692	metallophosphoesterase
IPM19_04350	COG1418	mRNA catabolic process
IPM19_04355	COG0450	alkyl hydroperoxide reductase
IPM19_04370	COG0335	large ribosomal subunit rRNA binding
IPM19_04375	COG0564	pseudouridine synthase activity
IPM19_04385	COG0336	Belongs to the RNA methyltransferase TrmD family
IPM19_04440	COG1196	nuclear chromosome segregation
IPM19_04445	COG0571	ribonuclease III activity
IPM19_04460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM19_04505	COG2182	Extracellular solute-binding protein
IPM19_04510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPM19_04515	COG0606	chelatase, subunit chli
IPM19_04535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPM19_04540	COG1426	Protein conserved in bacteria
IPM19_04545	COG1674	ftsk spoiiie
IPM19_04555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM19_04565	COG0237	dephospho-CoA kinase activity
IPM19_04580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPM19_04585	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IPM19_04620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPM19_04645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPM19_04655	COG0724	RNA recognition motif
IPM19_04685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPM19_04695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPM19_04700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM19_04770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM19_04775	COG0539	negative regulation of cytoplasmic translation
IPM19_04800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPM19_04820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPM19_04825	COG0217	transcriptional regulatory protein
IPM19_04830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPM19_04840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPM19_04845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM19_04855	COG0706	membrane insertase activity
IPM19_04860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPM19_04865	COG0594	ribonuclease P activity
IPM19_04870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPM19_04875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPM19_04880	COG0592	DNA-directed DNA polymerase activity
IPM19_04885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPM19_04895	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IPM19_04895	COG0662	Cupin 2, conserved barrel domain protein
IPM19_04910	COG2255	four-way junction helicase activity
IPM19_04915	COG2720	vancomycin resistance protein
IPM19_04920	COG0802	atpase or kinase
IPM19_04925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM19_04930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM19_04935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM19_04955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM19_04955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM19_04960	COG0268	Binds directly to 16S ribosomal RNA
IPM19_04965	COG0556	nucleotide-excision repair
IPM19_04995	COG1214	PFAM Peptidase M22, glycoprotease
IPM19_05005	COG1132	(ABC) transporter
IPM19_05015	COG0632	four-way junction helicase activity
IPM19_05020	COG0085	RNA polymerase activity
IPM19_05025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates