locus-tag	class	description
IPM44_00060	COG0071	Belongs to the small heat shock protein (HSP20) family
IPM44_00065	COG1040	competence protein
IPM44_00075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPM44_00120	COG1970	mechanosensitive ion channel activity
IPM44_00130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPM44_00135	COG1694	Mazg nucleotide pyrophosphohydrolase
IPM44_00150	COG0525	valine-tRNA ligase activity
IPM44_00155	COG0494	nUDIX hydrolase
IPM44_00160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM44_00190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM44_00215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPM44_00220	COG0459	protein refolding
IPM44_00255	COG2222	sugar isomerase
IPM44_00315	COG0584	glycerophosphoryl diester phosphodiesterase
IPM44_00340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPM44_00350	COG1316	TRANSCRIPTIONal
IPM44_00375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPM44_00405	COG0358	DNA primase activity
IPM44_00410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPM44_00420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM44_00420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM44_00430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPM44_00440	COG0268	Binds directly to 16S ribosomal RNA
IPM44_00445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPM44_00450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPM44_00460	COG1185	polyribonucleotide nucleotidyltransferase activity
IPM44_00465	COG1573	uracil-dna glycosylase
IPM44_00470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPM44_00475	COG1215	transferase activity, transferring glycosyl groups
IPM44_00480	COG1132	(ABC) transporter
IPM44_00485	COG1674	ftsk spoiiie
IPM44_00490	COG4412	M6 family metalloprotease domain protein
IPM44_00490	COG1404	Belongs to the peptidase S8 family
IPM44_00505	COG2137	regulation of response to DNA damage stimulus
IPM44_00515	COG0360	Binds together with S18 to 16S ribosomal RNA
IPM44_00520	COG0629	single-stranded DNA binding
IPM44_00525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPM44_00530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPM44_00535	COG0012	GTP binding
IPM44_00575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM44_00585	COG1459	type II secretion system
IPM44_00595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IPM44_00620	COG4974	Belongs to the 'phage' integrase family
IPM44_00635	COG0612	Peptidase, M16
IPM44_00640	COG0105	UTP biosynthetic process
IPM44_00660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPM44_00715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM44_00725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPM44_00730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM44_00745	COG0577	efflux transmembrane transporter activity
IPM44_00745	COG1136	(ABC) transporter
IPM44_00760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPM44_00765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM44_00780	COG0628	permease
IPM44_00790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPM44_00795	COG1994	Peptidase M50
IPM44_00815	COG1968	undecaprenyl-diphosphatase activity
IPM44_00835	COG0438	transferase activity, transferring glycosyl groups
IPM44_00845	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPM44_00850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPM44_00855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPM44_00880	COG0606	chelatase, subunit chli
IPM44_00890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM44_00925	COG1136	(ABC) transporter
IPM44_00930	COG1136	(ABC) transporter
IPM44_00930	COG0577	efflux transmembrane transporter activity
IPM44_00935	COG3588	fructose-bisphosphate aldolase
IPM44_00940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPM44_00945	COG0018	arginyl-trna synthetase
IPM44_00965	COG0180	Tryptophanyl-tRNA synthetase
IPM44_00975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPM44_00980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM44_00980	COG0072	phenylalanine-tRNA ligase activity
IPM44_01010	COG0187	DNA topoisomerase II activity
IPM44_01015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPM44_01025	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IPM44_01070	COG0412	Dienelactone hydrolase
IPM44_01075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPM44_01080	COG4733	cellulase activity
IPM44_01080	COG5297	Belongs to the glycosyl hydrolase family 6
IPM44_01145	COG3064	Membrane
IPM44_01145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPM44_01150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPM44_01155	COG4565	transcriptional regulatory protein
IPM44_01160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM44_01165	COG0242	peptide deformylase activity
IPM44_01170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPM44_01175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM44_01180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM44_01200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPM44_01200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPM44_01205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPM44_01210	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPM44_01215	COG1610	YqeY-like protein
IPM44_01220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPM44_01225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IPM44_01230	COG0563	adenylate kinase activity
IPM44_01235	COG0024	Methionine aminopeptidase
IPM44_01245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPM44_01250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM44_01260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM44_01265	COG0772	Belongs to the SEDS family
IPM44_01270	COG1525	nuclease
IPM44_01275	COG0492	ferredoxin-NADP+ reductase activity
IPM44_01295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPM44_01300	COG1192	Involved in chromosome partitioning
IPM44_01305	COG1475	DNA binding
IPM44_01310	COG0681	Belongs to the peptidase S26 family
IPM44_01325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM44_01340	COG2890	protein-(glutamine-N5) methyltransferase activity
IPM44_01345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM44_01350	COG0254	rRNA binding
IPM44_01370	COG0052	Belongs to the universal ribosomal protein uS2 family
IPM44_01375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPM44_01405	COG0750	zinc metalloprotease
IPM44_01410	COG1266	CAAX protease self-immunity
IPM44_01415	COG1077	Cell shape determining protein MreB Mrl
IPM44_01430	COG0768	penicillin binding
IPM44_01440	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IPM44_01445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPM44_01455	COG0653	protein targeting
IPM44_01490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPM44_01495	COG5265	(ABC) transporter
IPM44_01500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPM44_01505	COG2884	Cell division ATP-binding protein ftsE
IPM44_01510	COG2177	Part of the ABC transporter FtsEX involved in
IPM44_01535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IPM44_01550	COG0793	Belongs to the peptidase S41A family
IPM44_01550	COG3409	Peptidoglycan-binding domain 1 protein
IPM44_01555	COG0504	CTP synthase activity
IPM44_01560	COG0745	RESPONSE REGULATOR receiver
IPM44_01565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPM44_01580	COG1570	exodeoxyribonuclease VII activity
IPM44_01620	COG1077	Cell shape determining protein MreB Mrl
IPM44_01630	COG0438	transferase activity, transferring glycosyl groups
IPM44_01655	COG2267	carboxylic ester hydrolase activity
IPM44_01665	COG1611	Belongs to the LOG family
IPM44_01675	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPM44_01680	COG0142	geranyltranstransferase activity
IPM44_01690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPM44_01695	COG0250	Participates in transcription elongation, termination and antitermination
IPM44_01700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPM44_01705	COG0081	regulation of translation
IPM44_01710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM44_01710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM44_01720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPM44_01725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPM44_01740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPM44_01745	COG0222	ribosome binding
IPM44_01755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPM44_01760	COG0305	Participates in initiation and elongation during chromosome replication
IPM44_01790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPM44_01800	COG0215	cysteine-tRNA ligase activity
IPM44_01880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM44_01900	COG0488	(ABC) transporter
IPM44_01940	COG2198	Histidine kinase
IPM44_01940	COG5002	protein histidine kinase activity
IPM44_01940	COG0784	Response regulator, receiver
IPM44_01965	COG0784	Response regulator, receiver
IPM44_01965	COG2198	Histidine kinase
IPM44_01965	COG5002	protein histidine kinase activity
IPM44_01995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPM44_02010	COG1674	ftsk spoiiie
IPM44_02020	COG2827	Endonuclease containing a URI domain
IPM44_02025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPM44_02035	COG0596	Alpha beta hydrolase
IPM44_02040	COG1136	(ABC) transporter
IPM44_02045	COG1136	(ABC) transporter
IPM44_02045	COG0577	efflux transmembrane transporter activity
IPM44_02050	COG0513	Belongs to the DEAD box helicase family
IPM44_02060	COG0586	Pfam SNARE associated Golgi protein
IPM44_02070	COG0588	phosphoglycerate mutase activity
IPM44_02080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM44_02105	COG1215	transferase activity, transferring glycosyl groups
IPM44_02125	COG1470	cell adhesion involved in biofilm formation
IPM44_02200	COG1054	Belongs to the UPF0176 family
IPM44_02210	COG1132	(ABC) transporter
IPM44_02220	COG0343	queuine tRNA-ribosyltransferase activity
IPM44_02225	COG2816	NAD+ diphosphatase activity
IPM44_02235	COG5002	protein histidine kinase activity
IPM44_02240	COG0745	RESPONSE REGULATOR receiver
IPM44_02245	COG0017	Asparaginyl-tRNA synthetase
IPM44_02255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPM44_02260	COG1187	pseudouridine synthase activity
IPM44_02265	COG1686	Belongs to the peptidase S11 family
IPM44_02270	COG1160	GTP binding
IPM44_02275	COG0193	aminoacyl-tRNA hydrolase activity
IPM44_02280	COG0758	DNA mediated transformation
IPM44_02285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPM44_02305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM44_02310	COG0772	Belongs to the SEDS family
IPM44_02315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM44_02320	COG0768	penicillin binding
IPM44_02330	COG0275	rRNA processing
IPM44_02335	COG2001	Belongs to the MraZ family
IPM44_02345	COG0423	glycine-tRNA ligase activity
IPM44_02355	COG0745	RESPONSE REGULATOR receiver
IPM44_02385	COG0662	Cupin 2, conserved barrel domain protein
IPM44_02395	COG2217	Heavy metal translocating P-type atpase
IPM44_02415	COG1937	Protein conserved in bacteria
IPM44_02435	COG2205	protein histidine kinase activity
IPM44_02435	COG0784	Response regulator, receiver
IPM44_02435	COG5002	protein histidine kinase activity
IPM44_02470	COG0470	DNA polymerase III
IPM44_02475	COG0564	pseudouridine synthase activity
IPM44_02485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPM44_02490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPM44_02495	COG0203	ribosomal protein L17
IPM44_02500	COG0202	RNA polymerase activity
IPM44_02505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPM44_02510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPM44_02515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPM44_02520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPM44_02525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPM44_02535	COG0200	Binds to the 23S rRNA
IPM44_02540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPM44_02545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPM44_02550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPM44_02555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPM44_02565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPM44_02570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPM44_02575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPM44_02580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPM44_02590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPM44_02595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPM44_02600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPM44_02605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPM44_02610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPM44_02620	COG0088	Forms part of the polypeptide exit tunnel
IPM44_02625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPM44_02635	COG0051	transcription antitermination factor activity, RNA binding
IPM44_02640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM44_02650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM44_02655	COG0488	(ABC) transporter
IPM44_02680	COG0049	tRNA binding
IPM44_02685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPM44_02690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPM44_02695	COG0085	RNA polymerase activity
IPM44_02705	COG0740	serine-type endopeptidase activity
IPM44_02710	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPM44_02720	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPM44_02730	COG0742	ribosomal rna small subunit methyltransferase
IPM44_02740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPM44_02745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPM44_02750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM44_02750	COG4499	WXG100 protein secretion system (Wss), protein YukC
IPM44_02755	COG4956	integral membrane protein (PIN domain superfamily)
IPM44_02760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPM44_02765	COG0542	response to heat
IPM44_02770	COG0195	Participates in both transcription termination and antitermination
IPM44_02775	COG0792	nuclease activity
IPM44_02780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPM44_02800	COG0335	large ribosomal subunit rRNA binding
IPM44_02810	COG0194	GDP metabolic process
IPM44_02840	COG0668	transmembrane transport
IPM44_02845	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM44_02855	COG0154	amidase activity
IPM44_02860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM44_02870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM44_02880	COG0501	Belongs to the peptidase M48B family
IPM44_02885	COG1704	LemA family
IPM44_02910	COG1968	undecaprenyl-diphosphatase activity
IPM44_02920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM44_02920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM44_02985	COG0277	FAD linked oxidase domain protein
IPM44_03015	COG1950	PFAM Membrane protein of
IPM44_03025	COG0322	excinuclease ABC activity
IPM44_03045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPM44_03070	COG0556	nucleotide-excision repair
IPM44_03105	COG3634	alkyl hydroperoxide reductase activity
IPM44_03115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPM44_03115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPM44_03125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPM44_03130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IPM44_03140	COG0698	ribose 5-phosphate isomerase
IPM44_03160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPM44_03160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPM44_03175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPM44_03180	COG0708	Exodeoxyribonuclease III
IPM44_03210	COG0442	prolyl-tRNA aminoacylation
IPM44_03215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IPM44_03250	COG0277	FAD linked oxidase domain protein
IPM44_03250	COG0247	lactate metabolic process
IPM44_03255	COG0277	FAD linked oxidase domain protein
IPM44_03270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPM44_03295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM44_03300	COG0336	Belongs to the RNA methyltransferase TrmD family
IPM44_03310	COG0228	four-way junction DNA binding
IPM44_03315	COG1196	nuclear chromosome segregation
IPM44_03315	COG1196	nuclear chromosome segregation
IPM44_03335	COG0571	ribonuclease III activity
IPM44_03390	COG0495	leucyl-tRNA aminoacylation
IPM44_03410	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM44_03455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPM44_03465	COG1388	LysM domain
IPM44_03465	COG3942	CHAP domain
IPM44_03470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPM44_03475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPM44_03490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPM44_03500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM44_03520	COG0482	sulfurtransferase activity
IPM44_03525	COG0482	sulfurtransferase activity
IPM44_03540	COG1104	cysteine desulfurase activity
IPM44_03545	COG0084	hydrolase, TatD family'
IPM44_03555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM44_03555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM44_03570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPM44_03575	COG1388	LysM domain
IPM44_03585	COG1217	gtp-binding protein TYPA
IPM44_03590	COG0210	DNA helicase
IPM44_03600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPM44_03605	COG0149	triose-phosphate isomerase activity
IPM44_03615	COG0469	pyruvate kinase activity
IPM44_03625	COG5002	protein histidine kinase activity
IPM44_03640	COG1136	(ABC) transporter
IPM44_03640	COG0577	efflux transmembrane transporter activity
IPM44_03645	COG1136	(ABC) transporter
IPM44_03670	COG3942	CHAP domain
IPM44_03715	COG1373	ATPase (AAA superfamily
IPM44_03740	COG1136	(ABC) transporter
IPM44_03740	COG0577	efflux transmembrane transporter activity
IPM44_03780	COG2723	6-phospho-beta-galactosidase activity
IPM44_03790	COG0148	phosphopyruvate hydratase activity
IPM44_03800	COG0126	phosphoglycerate kinase activity
IPM44_03810	COG0784	Response regulator, receiver
IPM44_03815	COG5002	protein histidine kinase activity
IPM44_03825	COG0019	diaminopimelate decarboxylase activity
IPM44_03840	COG0488	(ABC) transporter
IPM44_03845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPM44_03940	COG2239	Acts as a magnesium transporter
IPM44_03945	COG1692	metallophosphoesterase
IPM44_03950	COG1418	mRNA catabolic process
IPM44_03955	COG0494	nUDIX hydrolase
IPM44_03960	COG1214	PFAM Peptidase M22, glycoprotease
IPM44_03975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM44_03980	COG1459	type II secretion system
IPM44_04015	COG2255	four-way junction helicase activity
IPM44_04030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPM44_04040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPM44_04050	COG0217	transcriptional regulatory protein
IPM44_04075	COG0189	ligase activity
IPM44_04080	COG0189	ligase activity
IPM44_04100	COG0484	heat shock protein binding
IPM44_04115	COG0443	Heat shock 70 kDa protein
IPM44_04120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM44_04140	COG3942	CHAP domain
IPM44_04140	COG1388	LysM domain
IPM44_04155	COG0481	GTPase activity
IPM44_04160	COG0728	peptidoglycan biosynthetic process
IPM44_04165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM44_04170	COG0037	tRNA processing
IPM44_04215	COG0842	Transport permease protein
IPM44_04220	COG1131	(ABC) transporter
IPM44_04245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPM44_04260	COG0281	malic enzyme
IPM44_04285	COG1216	Glycosyl transferase, family 2
IPM44_04285	COG0463	Glycosyl transferase, family 2
IPM44_04295	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IPM44_04310	COG1215	transferase activity, transferring glycosyl groups
IPM44_04325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPM44_04350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM44_04385	COG1131	(ABC) transporter
IPM44_04405	COG0438	transferase activity, transferring glycosyl groups
IPM44_04420	COG0531	amino acid
IPM44_04430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPM44_04480	COG0247	lactate metabolic process
IPM44_04480	COG0277	FAD linked oxidase domain protein
IPM44_04495	COG2205	protein histidine kinase activity
IPM44_04505	COG1017	nitric oxide dioxygenase activity
IPM44_04505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPM44_04510	COG1573	uracil-dna glycosylase
IPM44_04545	COG2720	vancomycin resistance protein
IPM44_04550	COG1847	R3H domain protein
IPM44_04560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPM44_04565	COG0594	ribonuclease P activity
IPM44_04570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPM44_04575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPM44_04580	COG0592	DNA-directed DNA polymerase activity
IPM44_04585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP