locus-tag	class	description
KFE80_00015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KFE80_00025	COG1984	allophanate hydrolase subunit 2
KFE80_00060	COG0616	signal peptide processing
KFE80_00075	COG1393	Belongs to the ArsC family
KFE80_00080	COG1295	ribonuclease BN
KFE80_00085	COG1254	Belongs to the acylphosphatase family
KFE80_00115	COG0822	iron-sulfur transferase activity
KFE80_00160	COG0105	UTP biosynthetic process
KFE80_00165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFE80_00180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KFE80_00185	COG0124	histidyl-tRNA synthetase
KFE80_00200	COG1160	GTP binding
KFE80_00215	COG1570	exodeoxyribonuclease VII activity
KFE80_00225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFE80_00225	COG0519	Catalyzes the synthesis of GMP from XMP
KFE80_00230	COG1395	domain, Protein
KFE80_00250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KFE80_00255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFE80_00255	COG0047	phosphoribosylformylglycinamidine synthase activity
KFE80_00435	COG0604	alcohol dehydrogenase
KFE80_00440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFE80_00440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFE80_00445	COG0489	protein tyrosine kinase activity
KFE80_00450	COG0717	Belongs to the dCTP deaminase family
KFE80_00485	COG0540	Belongs to the ATCase OTCase family
KFE80_00495	COG1199	ATP-dependent helicase activity
KFE80_00505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFE80_00535	COG2211	Major facilitator Superfamily
KFE80_00545	COG2211	Major facilitator Superfamily
KFE80_00550	COG0667	Aldo Keto reductase
KFE80_00555	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFE80_00560	COG1028	Short-chain dehydrogenase reductase Sdr
KFE80_00565	COG2721	sulfolactate sulfo-lyase activity
KFE80_00595	COG1304	FMN binding
KFE80_00605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFE80_00610	COG1940	carbohydrate kinase activity
KFE80_00615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KFE80_00620	COG0166	Belongs to the GPI family
KFE80_00630	COG1737	Transcriptional regulator
KFE80_00640	COG0363	glucosamine-6-phosphate deaminase activity
KFE80_00655	COG0067	glutamate synthase
KFE80_00655	COG0069	glutamate synthase activity
KFE80_00655	COG0070	glutamate synthase
KFE80_00660	COG0493	'glutamate synthase
KFE80_00665	COG2211	Major facilitator Superfamily
KFE80_00680	COG1472	Belongs to the glycosyl hydrolase 3 family
KFE80_00685	COG4771	TonB-dependent receptor
KFE80_00690	COG2814	Major facilitator Superfamily
KFE80_00695	COG2972	Histidine kinase
KFE80_00700	COG3279	Response regulator of the LytR AlgR family
KFE80_00705	COG0837	glucose binding
KFE80_00715	COG0004	ammonium transporteR
KFE80_00720	COG0347	Belongs to the P(II) protein family
KFE80_00730	COG1309	transcriptional regulator
KFE80_00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE80_00770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KFE80_00775	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KFE80_00810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFE80_00820	COG0354	folic acid binding
KFE80_00825	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KFE80_00855	COG3086	response to oxidative stress
KFE80_00860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFE80_00885	COG0481	GTPase activity
KFE80_00900	COG0571	ribonuclease III activity
KFE80_00905	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFE80_00910	COG1381	Involved in DNA repair and RecF pathway recombination
KFE80_00915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFE80_00920	COG3956	TIGRFAM MazG family protein
KFE80_00925	COG0563	adenylate kinase activity
KFE80_00940	COG1214	PFAM Peptidase M22, glycoprotease
KFE80_00945	COG1968	undecaprenyl-diphosphatase activity
KFE80_00950	COG2084	Dehydrogenase
KFE80_00960	COG0697	spore germination
KFE80_00965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFE80_00975	COG0037	tRNA processing
KFE80_00980	COG0488	(ABC) transporter
KFE80_00995	COG0018	arginyl-trna synthetase
KFE80_01005	COG5016	pyruvate
KFE80_01005	COG0511	ligase activity, forming carbon-carbon bonds
KFE80_01010	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KFE80_01020	COG0271	Belongs to the BolA IbaG family
KFE80_01025	COG0513	Belongs to the DEAD box helicase family
KFE80_01030	COG0121	glutamine amidotransferase
KFE80_01035	COG3047	cAMP biosynthetic process
KFE80_01040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFE80_01075	COG4133	protoheme IX ABC transporter activity
KFE80_01095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KFE80_01115	COG3209	COG3209 Rhs family protein
KFE80_01125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFE80_01135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KFE80_01140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFE80_01145	COG1294	oxidase, subunit
KFE80_01150	COG1271	oxidase subunit
KFE80_01190	COG2165	general secretion pathway protein
KFE80_01205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KFE80_01225	COG0386	Belongs to the glutathione peroxidase family
KFE80_01230	COG2234	aminopeptidase activity
KFE80_01235	COG0534	Mate efflux family protein
KFE80_01240	COG5002	protein histidine kinase activity
KFE80_01240	COG3850	Histidine kinase
KFE80_01245	COG0745	RESPONSE REGULATOR receiver
KFE80_01290	COG0390	transport system, permease component
KFE80_01295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KFE80_01305	COG2326	polyphosphate kinase activity
KFE80_01310	COG0613	PHP domain protein
KFE80_01320	COG0514	ATP-dependent DNA helicase (RecQ)
KFE80_01325	COG3483	tryptophan 2,3-dioxygenase activity
KFE80_01345	COG2813	Specifically methylates the guanine in position
KFE80_01350	COG0714	Associated with various cellular activities
KFE80_01365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFE80_01375	COG2897	thiosulfate sulfurtransferase activity
KFE80_01390	COG1858	cytochrome C peroxidase
KFE80_01395	COG5001	Diguanylate cyclase
KFE80_01395	COG5002	protein histidine kinase activity
KFE80_01410	COG1136	(ABC) transporter
KFE80_01410	COG0577	efflux transmembrane transporter activity
KFE80_01420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFE80_01430	COG0735	belongs to the Fur family
KFE80_01440	COG4172	Belongs to the ABC transporter superfamily
KFE80_01445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFE80_01450	COG0601	transmembrane transport
KFE80_01460	COG1506	peptidase
KFE80_01460	COG0823	Involved in the tonB-independent uptake of proteins
KFE80_01460	COG4946	Tricorn protease homolog
KFE80_01475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFE80_01480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFE80_01495	COG2983	Belongs to the UPF0260 family
KFE80_01505	COG0189	ligase activity
KFE80_01505	COG4067	protein conserved in archaea
KFE80_01530	COG1595	DNA-templated transcription, initiation
KFE80_01540	COG2183	response to ionizing radiation
KFE80_01550	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFE80_01550	COG1024	Enoyl-CoA hydratase
KFE80_01555	COG0183	Belongs to the thiolase family
KFE80_01570	COG0544	peptidyl-prolyl cis-trans isomerase activity
KFE80_01575	COG0740	serine-type endopeptidase activity
KFE80_01580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFE80_01585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KFE80_01595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFE80_01600	COG0741	lytic transglycosylase activity
KFE80_01600	COG1388	LysM domain
KFE80_01605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFE80_01615	COG0328	RNA-DNA hybrid ribonuclease activity
KFE80_01630	COG2816	NAD+ diphosphatase activity
KFE80_01635	COG0616	signal peptide processing
KFE80_01675	COG0583	DNA-binding transcription factor activity
KFE80_01690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFE80_01695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFE80_01715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFE80_01720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFE80_01725	COG0432	Pfam Uncharacterised protein family UPF0047
KFE80_01730	COG3273	potassium ion transport
KFE80_01730	COG0471	metal ion transport
KFE80_01740	COG3122	Protein conserved in bacteria
KFE80_01755	COG2081	HI0933 family
KFE80_01765	COG1739	Uncharacterized protein family UPF0029
KFE80_01780	COG1297	OPT oligopeptide transporter protein
KFE80_01785	COG3104	oligopeptide transport
KFE80_01790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KFE80_01790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFE80_01800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KFE80_01805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KFE80_01815	COG3089	Belongs to the UPF0270 family
KFE80_01825	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
KFE80_01835	COG0425	Belongs to the sulfur carrier protein TusA family
KFE80_01850	COG3101	peptidyl-lysine hydroxylation
KFE80_01860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFE80_01870	COG0436	Aminotransferase
KFE80_01905	COG1131	(ABC) transporter
KFE80_01910	COG0842	Transport permease protein
KFE80_01915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFE80_01915	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFE80_01930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE80_01935	COG0435	Glutathione S-transferase
KFE80_01940	COG0583	DNA-binding transcription factor activity
KFE80_01950	COG2249	NAD(P)H dehydrogenase (quinone) activity
KFE80_01955	COG1733	regulation of RNA biosynthetic process
KFE80_01960	COG1741	Belongs to the pirin family
KFE80_01970	COG0778	Nitroreductase
KFE80_01985	COG2304	oxidoreductase activity
KFE80_02005	COG0714	Associated with various cellular activities
KFE80_02015	COG0167	dihydroorotate dehydrogenase activity
KFE80_02020	COG3130	regulation of translation
KFE80_02025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KFE80_02025	COG0116	Belongs to the methyltransferase superfamily
KFE80_02035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFE80_02035	COG0574	Belongs to the PEP-utilizing enzyme family
KFE80_02040	COG2501	S4 domain
KFE80_02045	COG0484	heat shock protein binding
KFE80_02055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KFE80_02070	COG0625	glutathione transferase activity
KFE80_02085	COG2995	paraquat-inducible protein a
KFE80_02105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFE80_02115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFE80_02120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFE80_02125	COG0215	cysteine-tRNA ligase activity
KFE80_02130	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KFE80_02135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KFE80_02140	COG0786	glutamate:sodium symporter activity
KFE80_02150	COG0583	DNA-binding transcription factor activity
KFE80_02155	COG4206	TonB-dependent receptor
KFE80_02170	COG0405	Gamma-glutamyltransferase
KFE80_02185	COG0405	Gamma-glutamyltransferase
KFE80_02200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFE80_02215	COG0596	Alpha beta hydrolase
KFE80_02220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFE80_02225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KFE80_02230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFE80_02245	COG0084	hydrolase, TatD family'
KFE80_02255	COG0039	L-malate dehydrogenase activity
KFE80_02260	COG1595	DNA-templated transcription, initiation
KFE80_02275	COG0405	Gamma-glutamyltransferase
KFE80_02290	COG2133	pyrroloquinoline quinone binding
KFE80_02295	COG0302	gtp cyclohydrolase
KFE80_02305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFE80_02310	COG2814	Major facilitator Superfamily
KFE80_02335	COG0583	DNA-binding transcription factor activity
KFE80_02365	COG5001	Diguanylate cyclase
KFE80_02370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFE80_02385	COG1668	transmembrane transport
KFE80_02390	COG4555	ABC transporter
KFE80_02400	COG2009	succinate dehydrogenase
KFE80_02415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFE80_02420	COG1862	Preprotein translocase
KFE80_02425	COG1115	amino acid carrier protein
KFE80_02435	COG1309	transcriptional regulator
KFE80_02470	COG0708	Exodeoxyribonuclease III
KFE80_02475	COG0793	Belongs to the peptidase S41A family
KFE80_02485	COG1720	tRNA m6t6A37 methyltransferase activity
KFE80_02490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFE80_02495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFE80_02500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KFE80_02505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KFE80_02510	COG1674	ftsk spoiiie
KFE80_02515	COG0492	ferredoxin-NADP+ reductase activity
KFE80_02520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KFE80_02525	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KFE80_02530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFE80_02535	COG0542	response to heat
KFE80_02540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KFE80_02545	COG1278	Cold shock
KFE80_02565	COG1160	GTP binding
KFE80_02575	COG0482	sulfurtransferase activity
KFE80_02580	COG2915	High frequency lysogenization protein hflD homolog
KFE80_02590	COG2850	peptidyl-arginine hydroxylation
KFE80_02610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFE80_02625	COG0416	fatty acid biosynthetic process
KFE80_02630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFE80_02640	COG0424	maF-like protein
KFE80_02645	COG0546	phosphoglycolate phosphatase activity
KFE80_02650	COG0564	pseudouridine synthase activity
KFE80_02655	COG1530	ribonuclease E activity
KFE80_02675	COG0670	Belongs to the BI1 family
KFE80_02680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KFE80_02700	COG3283	Transcriptional regulator of aromatic amino acids metabolism
KFE80_02710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KFE80_02720	COG0625	glutathione transferase activity
KFE80_02730	COG0400	carboxylic ester hydrolase activity
KFE80_02750	COG0045	succinate-CoA ligase (ADP-forming) activity
KFE80_02775	COG1053	succinate dehydrogenase
KFE80_02810	COG1286	toxin biosynthetic process
KFE80_02820	COG0285	dihydrofolate synthase activity
KFE80_02825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFE80_02830	COG0159	tryptophan synthase activity
KFE80_02840	COG0135	phosphoribosylanthranilate isomerase activity
KFE80_02845	COG0101	tRNA pseudouridine synthase activity
KFE80_02855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFE80_02865	COG0473	3-isopropylmalate dehydrogenase activity
KFE80_02875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFE80_02885	COG1960	acyl-CoA dehydrogenase activity
KFE80_02895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFE80_02960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KFE80_02965	COG3012	SEC-C Motif Domain Protein
KFE80_02970	COG3228	Belongs to the MtfA family
KFE80_02980	COG2974	May be involved in recombination
KFE80_03010	COG2828	Protein conserved in bacteria
KFE80_03020	COG0372	Belongs to the citrate synthase family
KFE80_03025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KFE80_03030	COG1802	Transcriptional regulator
KFE80_03045	COG1136	(ABC) transporter
KFE80_03070	COG1477	protein flavinylation
KFE80_03075	COG2871	sodium ion transport
KFE80_03080	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFE80_03095	COG1805	sodium ion transport
KFE80_03100	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFE80_03145	COG1696	Membrane protein involved in D-alanine export
KFE80_03195	COG5002	protein histidine kinase activity
KFE80_03205	COG3273	potassium ion transport
KFE80_03205	COG0471	metal ion transport
KFE80_03210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFE80_03210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KFE80_03215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KFE80_03215	COG0165	Argininosuccinate lyase
KFE80_03220	COG0137	argininosuccinate synthase activity
KFE80_03225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFE80_03230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KFE80_03310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KFE80_03315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFE80_03320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFE80_03325	COG1663	tetraacyldisaccharide 4'-kinase activity
KFE80_03330	COG1132	(ABC) transporter
KFE80_03335	COG0848	biopolymer transport protein
KFE80_03340	COG0811	peptide transport
KFE80_03355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFE80_03365	COG2827	Endonuclease containing a URI domain
KFE80_03375	COG2900	Belongs to the SlyX family
KFE80_03385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFE80_03415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KFE80_03420	COG0668	transmembrane transport
KFE80_03425	COG1472	Belongs to the glycosyl hydrolase 3 family
KFE80_03435	COG1063	alcohol dehydrogenase
KFE80_03450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFE80_03470	COG0589	response to stress
KFE80_03490	COG0850	regulation of cytokinetic process
KFE80_03495	COG2894	cell division
KFE80_03500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KFE80_03505	COG1643	Atp-dependent helicase
KFE80_03535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFE80_03550	COG1643	Atp-dependent helicase
KFE80_03605	COG0308	aminopeptidase N
KFE80_03615	COG3139	Protein of unknown function (DUF1315)
KFE80_03625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFE80_03645	COG0720	synthase
KFE80_03650	COG1090	epimerase
KFE80_03665	COG0776	regulation of translation
KFE80_03675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFE80_03680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFE80_03685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KFE80_03695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFE80_03740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFE80_03745	COG0438	transferase activity, transferring glycosyl groups
KFE80_03775	COG2089	acid synthase
KFE80_03800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFE80_03805	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KFE80_03820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFE80_03825	COG1086	Polysaccharide biosynthesis protein
KFE80_03840	COG1555	photosystem II stabilization
KFE80_03840	COG1596	polysaccharide export
KFE80_03845	COG0284	orotidine-5'-phosphate decarboxylase activity
KFE80_03850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KFE80_03860	COG0776	regulation of translation
KFE80_03870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KFE80_03875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KFE80_03880	COG1605	Chorismate mutase
KFE80_03880	COG0077	Prephenate dehydratase
KFE80_03890	COG0402	S-adenosylhomocysteine deaminase activity
KFE80_03905	COG1028	Short-chain dehydrogenase reductase Sdr
KFE80_03910	COG4771	TonB-dependent receptor
KFE80_03920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KFE80_03930	COG0009	L-threonylcarbamoyladenylate synthase
KFE80_03960	COG0028	Belongs to the TPP enzyme family
KFE80_03970	COG2350	Protein conserved in bacteria
KFE80_03985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KFE80_03990	COG4109	DRTGG domain
KFE80_04005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFE80_04010	COG0024	Methionine aminopeptidase
KFE80_04015	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KFE80_04025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFE80_04035	COG1393	Belongs to the ArsC family
KFE80_04040	COG2171	N-acyltransferase activity
KFE80_04045	COG0783	Belongs to the Dps family
KFE80_04050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFE80_04060	COG0742	ribosomal rna small subunit methyltransferase
KFE80_04070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KFE80_04075	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KFE80_04080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFE80_04085	COG1560	Kdo2-lipid A biosynthetic process
KFE80_04150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFE80_04155	COG0129	dihydroxy-acid dehydratase activity
KFE80_04160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KFE80_04190	COG0028	Belongs to the TPP enzyme family
KFE80_04205	COG4106	trans-aconitate 2-methyltransferase activity
KFE80_04210	COG0500	methyltransferase
KFE80_04275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFE80_04285	COG2207	Transcriptional regulator
KFE80_04300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFE80_04305	COG2201	protein-glutamate methylesterase activity
KFE80_04320	COG0640	Transcriptional regulator
KFE80_04325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFE80_04340	COG2205	protein histidine kinase activity
KFE80_04375	COG2853	Lipoprotein
KFE80_04395	COG3220	belongs to the UPF0276 family
KFE80_04405	COG1643	Atp-dependent helicase
KFE80_04410	COG0318	PFAM AMP-dependent synthetase and ligase
KFE80_04415	COG1714	RDD family
KFE80_04420	COG0121	glutamine amidotransferase
KFE80_04435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KFE80_04450	COG1074	ATP-dependent DNA helicase activity
KFE80_04455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KFE80_04460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFE80_04460	COG0316	Belongs to the HesB IscA family
KFE80_04480	COG0475	glutathione-regulated potassium exporter activity
KFE80_04480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFE80_04485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KFE80_04495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KFE80_04495	COG3008	intermembrane lipid transfer
KFE80_04505	COG0686	Belongs to the AlaDH PNT family
KFE80_04515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KFE80_04530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KFE80_04535	COG0527	aspartate kinase activity
KFE80_04540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFE80_04545	COG0537	adenosine 5'-monophosphoramidase activity
KFE80_04550	COG2835	tetraacyldisaccharide 4'-kinase activity
KFE80_04565	COG2137	regulation of response to DNA damage stimulus
KFE80_04570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFE80_04580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE80_04590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFE80_04595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KFE80_04610	COG1388	LysM domain
KFE80_04610	COG4942	peptidase
KFE80_04620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KFE80_04625	COG0585	pseudouridine synthase activity
KFE80_04630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KFE80_04635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KFE80_04640	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KFE80_04645	COG0148	phosphopyruvate hydratase activity
KFE80_04655	COG0504	CTP synthase activity
KFE80_04660	COG0037	tRNA processing
KFE80_04665	COG0825	malonyl-CoA metabolic process
KFE80_04670	COG0587	DNA-directed DNA polymerase activity
KFE80_04675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFE80_04680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFE80_04690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFE80_04705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KFE80_04715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KFE80_04720	COG0575	Belongs to the CDS family
KFE80_04730	COG0233	cytoplasmic translational termination
KFE80_04740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFE80_04745	COG0052	Belongs to the universal ribosomal protein uS2 family
KFE80_04755	COG1404	Belongs to the peptidase S8 family
KFE80_04765	COG1595	DNA-templated transcription, initiation
KFE80_04785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFE80_04790	COG3115	cell septum assembly
KFE80_04795	COG1196	nuclear chromosome segregation
KFE80_04805	COG4235	cytochrome complex assembly
KFE80_04805	COG3088	subunit of a heme lyase
KFE80_04815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFE80_04820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KFE80_04825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFE80_04830	COG1492	cobalamin metabolic process
KFE80_04835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KFE80_04840	COG4206	TonB-dependent receptor
KFE80_04860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KFE80_04880	COG0335	large ribosomal subunit rRNA binding
KFE80_04885	COG0336	Belongs to the RNA methyltransferase TrmD family
KFE80_04890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFE80_04895	COG0228	four-way junction DNA binding
KFE80_04900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFE80_04910	COG4536	flavin adenine dinucleotide binding
KFE80_04925	COG1178	ABC-type Fe3 transport system permease component
KFE80_04930	COG3842	ATPase activity
KFE80_04935	COG4774	siderophore transport
KFE80_04950	COG2962	Rard protein
KFE80_04965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KFE80_04975	COG1573	uracil-dna glycosylase
KFE80_04980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFE80_04980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFE80_04985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KFE80_05005	COG0795	lipopolysaccharide-transporting ATPase activity
KFE80_05010	COG0795	lipopolysaccharide-transporting ATPase activity
KFE80_05015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFE80_05030	COG0525	valine-tRNA ligase activity
KFE80_05055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KFE80_05070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KFE80_05110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFE80_05125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFE80_05145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KFE80_05150	COG0628	permease
KFE80_05195	COG0442	prolyl-tRNA aminoacylation
KFE80_05225	COG0343	queuine tRNA-ribosyltransferase activity
KFE80_05230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFE80_05245	COG0523	cobalamin synthesis protein
KFE80_05275	COG3272	Protein of unknown function (DUF1722)
KFE80_05280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KFE80_05285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KFE80_05340	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KFE80_05365	COG2766	serine protein kinase
KFE80_05370	COG2718	Belongs to the UPF0229 family
KFE80_05375	COG2719	SpoVR family
KFE80_05380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KFE80_05380	COG0493	'glutamate synthase
KFE80_05385	COG0674	pyruvate-flavodoxin oxidoreductase activity
KFE80_05385	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KFE80_05395	COG0617	tRNA 3'-terminal CCA addition
KFE80_05410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFE80_05415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFE80_05420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KFE80_05430	COG0358	DNA primase activity
KFE80_05445	COG0513	Belongs to the DEAD box helicase family
KFE80_05470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFE80_05480	COG3300	MHYT domain
KFE80_05480	COG5001	Diguanylate cyclase
KFE80_05485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFE80_05490	COG0023	Translation Initiation Factor
KFE80_05605	COG1684	flagellar biosynthetic protein fliR
KFE80_05610	COG1987	bacterial-type flagellum assembly
KFE80_05635	COG0405	Gamma-glutamyltransferase
KFE80_05660	COG1982	Orn Lys Arg decarboxylase major
KFE80_05665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFE80_05675	COG0339	signal peptide processing
KFE80_05685	COG2020	methyltransferase activity
KFE80_05715	COG1677	Flagellar hook-basal body complex protein FliE
KFE80_05765	COG1256	bacterial-type flagellum assembly
KFE80_05770	COG1705	Flagellar rod assembly protein muramidase FlgJ
KFE80_05770	COG3951	Flagellar rod assembly protein muramidase FlgJ
KFE80_05775	COG1706	bacterial-type flagellum-dependent cell motility
KFE80_05780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KFE80_05790	COG4787	bacterial-type flagellum-dependent cell motility
KFE80_05800	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KFE80_05805	COG1558	bacterial-type flagellum-dependent cell motility
KFE80_05810	COG1815	bacterial-type flagellum-dependent cell motility
KFE80_05815	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
KFE80_05830	COG2925	Exonuclease
KFE80_05835	COG3047	cAMP biosynthetic process
KFE80_05835	COG2885	chlorophyll binding
KFE80_05840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KFE80_05840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KFE80_05855	COG0531	amino acid
KFE80_05860	COG4946	Tricorn protease homolog
KFE80_05860	COG1506	peptidase
KFE80_05860	COG0823	Involved in the tonB-independent uptake of proteins
KFE80_05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFE80_05885	COG0601	transmembrane transport
KFE80_05890	COG4608	Belongs to the ABC transporter superfamily
KFE80_05895	COG0444	Belongs to the ABC transporter superfamily
KFE80_05900	COG4166	transmembrane transport
KFE80_05910	COG4166	transmembrane transport
KFE80_05915	COG0747	negative chemotaxis
KFE80_05930	COG1696	Membrane protein involved in D-alanine export
KFE80_05940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFE80_05945	COG0459	protein refolding
KFE80_05950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFE80_05960	COG3695	enzyme binding
KFE80_05965	COG2814	Major facilitator Superfamily
KFE80_05985	COG3023	N-Acetylmuramoyl-L-alanine amidase
KFE80_06005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFE80_06010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KFE80_06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFE80_06035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KFE80_06145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFE80_06150	COG0602	queuosine metabolic process
KFE80_06155	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KFE80_06165	COG0823	Involved in the tonB-independent uptake of proteins
KFE80_06185	COG0824	Thioesterase
KFE80_06190	COG2255	four-way junction helicase activity
KFE80_06195	COG0632	four-way junction helicase activity
KFE80_06215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KFE80_06265	COG4969	Belongs to the N-Me-Phe pilin family
KFE80_06270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KFE80_06275	COG1047	Peptidyl-prolyl cis-trans
KFE80_06280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFE80_06285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFE80_06290	COG0196	riboflavin kinase activity
KFE80_06295	COG0728	peptidoglycan biosynthetic process
KFE80_06300	COG0268	Binds directly to 16S ribosomal RNA
KFE80_06305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFE80_06310	COG5007	Belongs to the BolA IbaG family
KFE80_06330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KFE80_06345	COG1137	ATPase activity
KFE80_06365	COG1660	Displays ATPase and GTPase activities
KFE80_06370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFE80_06375	COG2239	Acts as a magnesium transporter
KFE80_06380	COG3028	Belongs to the UPF0307 family
KFE80_06385	COG0436	Aminotransferase
KFE80_06390	COG1185	polyribonucleotide nucleotidyltransferase activity
KFE80_06395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFE80_06400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFE80_06405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFE80_06410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KFE80_06415	COG0195	Participates in both transcription termination and antitermination
KFE80_06415	COG2251	uridine kinase activity
KFE80_06420	COG0779	Required for maturation of 30S ribosomal subunits
KFE80_06435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFE80_06440	COG0149	triose-phosphate isomerase activity
KFE80_06445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFE80_06450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFE80_06455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFE80_06460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KFE80_06495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFE80_06500	COG0505	Belongs to the CarA family
KFE80_06525	COG1960	acyl-CoA dehydrogenase activity
KFE80_06540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFE80_06545	COG2353	YceI-like domain
KFE80_06560	COG0484	heat shock protein binding
KFE80_06565	COG0443	Heat shock 70 kDa protein
KFE80_06570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFE80_06575	COG0497	DNA recombination
KFE80_06610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KFE80_06645	COG3830	Belongs to the UPF0237 family
KFE80_06645	COG0560	Phosphoserine phosphatase
KFE80_06660	COG1960	acyl-CoA dehydrogenase activity
KFE80_06665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFE80_06675	COG4770	biotin carboxylase activity
KFE80_06685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KFE80_06690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KFE80_06705	COG0686	Belongs to the AlaDH PNT family
KFE80_06715	COG1671	Belongs to the UPF0178 family
KFE80_06725	COG0386	Belongs to the glutathione peroxidase family
KFE80_06745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFE80_06750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KFE80_06755	COG1876	peptidase activity
KFE80_06760	COG0668	transmembrane transport
KFE80_06770	COG0501	Belongs to the peptidase M48B family
KFE80_06775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFE80_06785	COG4771	TonB-dependent receptor
KFE80_06790	COG0457	Tetratricopeptide repeat
KFE80_06810	COG2046	Belongs to the sulfate adenylyltransferase family
KFE80_06810	COG0529	Catalyzes the synthesis of activated sulfate
KFE80_06830	COG1960	acyl-CoA dehydrogenase activity
KFE80_06860	COG1757	Na H antiporter
KFE80_06925	COG4783	chaperone-mediated protein folding
KFE80_06930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFE80_06965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KFE80_06970	COG2226	methyltransferase
KFE80_06970	COG1073	alpha beta
KFE80_06975	COG0156	8-amino-7-oxononanoate synthase activity
KFE80_06980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KFE80_07020	COG0488	(ABC) transporter
KFE80_07040	COG3038	cytochrome b561
KFE80_07060	COG2207	Transcriptional regulator
KFE80_07070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFE80_07070	COG0519	Catalyzes the synthesis of GMP from XMP
KFE80_07085	COG1522	sequence-specific DNA binding
KFE80_07105	COG0022	dehydrogenase e1 component
KFE80_07120	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
KFE80_07135	COG2259	Doxx family
KFE80_07140	COG0069	glutamate synthase activity
KFE80_07150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KFE80_07155	COG1054	Belongs to the UPF0176 family
KFE80_07175	COG2890	protein-(glutamine-N5) methyltransferase activity
KFE80_07180	COG2188	Transcriptional regulator
KFE80_07195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFE80_07215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFE80_07220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFE80_07230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KFE80_07235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KFE80_07245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFE80_07250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFE80_07255	COG0193	aminoacyl-tRNA hydrolase activity
KFE80_07280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFE80_07340	COG1006	Multisubunit Na H antiporter MnhC subunit
KFE80_07345	COG0651	ATP synthesis coupled electron transport
KFE80_07350	COG0651	ATP synthesis coupled electron transport
KFE80_07360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KFE80_07360	COG2111	Na H antiporter
KFE80_07370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFE80_07390	COG2801	Transposase and inactivated derivatives
KFE80_07470	COG0625	glutathione transferase activity
KFE80_07475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KFE80_07480	COG0321	lipoyl(octanoyl) transferase activity
KFE80_07485	COG2921	Belongs to the UPF0250 family
KFE80_07490	COG1686	Belongs to the peptidase S11 family
KFE80_07500	COG2951	lytic endotransglycosylase activity
KFE80_07505	COG0772	Belongs to the SEDS family
KFE80_07510	COG0768	penicillin binding
KFE80_07515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFE80_07525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFE80_07530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KFE80_07545	COG0501	Belongs to the peptidase M48B family
KFE80_07550	COG1704	LemA family
KFE80_07555	COG2205	protein histidine kinase activity
KFE80_07560	COG0745	RESPONSE REGULATOR receiver
KFE80_07580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFE80_07595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFE80_07600	COG0205	6-phosphofructokinase activity
KFE80_07610	COG1490	D-aminoacyl-tRNA deacylase activity
KFE80_07615	COG0596	Alpha beta hydrolase
KFE80_07640	COG0519	Catalyzes the synthesis of GMP from XMP
KFE80_07655	COG1217	gtp-binding protein TYPA
KFE80_07660	COG2165	general secretion pathway protein
KFE80_07665	COG0789	Transcriptional regulator
KFE80_07705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KFE80_07720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFE80_07725	COG0084	hydrolase, TatD family'
KFE80_07740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFE80_07740	COG0301	tRNA thio-modification
KFE80_07750	COG0174	glutamine synthetase
KFE80_07760	COG3852	Histidine kinase
KFE80_07765	COG2204	response regulator
KFE80_07775	COG2873	o-acetylhomoserine
KFE80_07780	COG5001	Diguanylate cyclase
KFE80_07780	COG5002	protein histidine kinase activity
KFE80_07795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KFE80_07800	COG0511	ligase activity, forming carbon-carbon bonds
KFE80_07815	COG2264	protein methyltransferase activity
KFE80_07825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KFE80_07835	COG0138	bifunctional purine biosynthesis protein purh
KFE80_07840	COG0431	NADPH-dependent FMN reductase
KFE80_07850	COG0151	Belongs to the GarS family
KFE80_07865	COG3327	negative regulation of DNA-templated transcription, initiation
KFE80_07880	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFE80_07890	COG2030	dehydratase
KFE80_07890	COG1012	belongs to the aldehyde dehydrogenase family
KFE80_07895	COG1024	Enoyl-CoA hydratase
KFE80_07900	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFE80_07905	COG0183	Belongs to the thiolase family
KFE80_07940	COG3396	Phenylacetate-CoA oxygenase
KFE80_07945	COG3460	Phenylacetate-CoA oxygenase
KFE80_07950	COG3396	Phenylacetate-CoA oxygenase
KFE80_07955	COG2151	metal-sulfur cluster biosynthetic enzyme
KFE80_07960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KFE80_07965	COG2200	EAL domain
KFE80_07975	COG0469	pyruvate kinase activity
KFE80_07985	COG3046	protein related to deoxyribodipyrimidine photolyase
KFE80_07990	COG0415	Belongs to the DNA photolyase family
KFE80_07995	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KFE80_08015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KFE80_08030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFE80_08035	COG4942	peptidase
KFE80_08040	COG0793	Belongs to the peptidase S41A family
KFE80_08050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFE80_08055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KFE80_08060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KFE80_08065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFE80_08085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFE80_08085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFE80_08095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFE80_08105	COG3081	Nucleoid-associated protein
KFE80_08115	COG1760	l-serine dehydratase
KFE80_08125	COG0784	Response regulator, receiver
KFE80_08125	COG0643	Histidine kinase
KFE80_08125	COG2198	Histidine kinase
KFE80_08135	COG0840	transmembrane signaling receptor activity
KFE80_08155	COG0189	ligase activity
KFE80_08165	COG1678	Uncharacterized ACR, COG1678
KFE80_08170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KFE80_08200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFE80_08205	COG2813	Specifically methylates the guanine in position
KFE80_08205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFE80_08215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFE80_08225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFE80_08230	COG2832	Protein of unknown function (DUF454)
KFE80_08245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFE80_08250	COG0006	proline dipeptidase activity
KFE80_08255	COG3079	Belongs to the UPF0149 family
KFE80_08275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFE80_08280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KFE80_08290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFE80_08300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFE80_08305	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KFE80_08310	COG0583	DNA-binding transcription factor activity
KFE80_08320	COG1765	OsmC-like protein
KFE80_08330	COG0134	indole-3-glycerol-phosphate synthase activity
KFE80_08335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFE80_08355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFE80_08360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KFE80_08365	COG2311	Membrane
KFE80_08385	COG4067	protein conserved in archaea
KFE80_08385	COG0189	ligase activity
KFE80_08390	COG1012	belongs to the aldehyde dehydrogenase family
KFE80_08405	COG0318	PFAM AMP-dependent synthetase and ligase
KFE80_08415	COG1752	Esterase of the alpha-beta hydrolase superfamily
KFE80_08425	COG1215	transferase activity, transferring glycosyl groups
KFE80_08435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KFE80_08445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFE80_08450	COG3313	Fe-S protein
KFE80_08455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KFE80_08460	COG0848	biopolymer transport protein
KFE80_08465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFE80_08470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFE80_08475	COG2003	Belongs to the UPF0758 family
KFE80_08490	COG1309	transcriptional regulator
KFE80_08505	COG0708	Exodeoxyribonuclease III
KFE80_08510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KFE80_08520	COG1027	Aspartate ammonia-lyase
KFE80_08525	COG0583	DNA-binding transcription factor activity
KFE80_08540	COG1506	peptidase
KFE80_08540	COG0823	Involved in the tonB-independent uptake of proteins
KFE80_08540	COG4946	Tricorn protease homolog
KFE80_08550	COG1561	YicC-like family, N-terminal region
KFE80_08560	COG0194	GDP metabolic process
KFE80_08565	COG0189	ligase activity
KFE80_08570	COG1758	RNA polymerase activity
KFE80_08575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KFE80_08605	COG0583	DNA-binding transcription factor activity
KFE80_08610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFE80_08620	COG4774	siderophore transport
KFE80_08635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFE80_08660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFE80_08665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFE80_08675	COG0210	DNA helicase
KFE80_08685	COG1737	Transcriptional regulator
KFE80_08695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFE80_08705	COG1187	pseudouridine synthase activity
KFE80_08755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KFE80_08760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFE80_08770	COG4771	TonB-dependent receptor
KFE80_08790	COG1115	amino acid carrier protein
KFE80_08805	COG1028	Short-chain dehydrogenase reductase Sdr
KFE80_08845	COG1119	ATPase activity
KFE80_08925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFE80_08930	COG0569	domain protein
KFE80_08935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFE80_08940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFE80_08945	COG0242	peptide deformylase activity
KFE80_08955	COG0758	DNA mediated transformation
KFE80_08965	COG0009	L-threonylcarbamoyladenylate synthase
KFE80_08970	COG0408	coproporphyrinogen oxidase activity
KFE80_08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE80_08990	COG0671	phosphoesterase, PA-phosphatase related
KFE80_09020	COG2918	glutathione biosynthetic process
KFE80_09030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KFE80_09055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFE80_09060	COG2363	Small membrane protein
KFE80_09070	COG2177	Part of the ABC transporter FtsEX involved in
KFE80_09075	COG2884	Cell division ATP-binding protein ftsE
KFE80_09080	COG0552	protein localization to endoplasmic reticulum
KFE80_09085	COG0742	ribosomal rna small subunit methyltransferase
KFE80_09090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFE80_09095	COG1611	Belongs to the LOG family
KFE80_09105	COG1595	DNA-templated transcription, initiation
KFE80_09115	COG4206	TonB-dependent receptor
KFE80_09140	COG0126	phosphoglycerate kinase activity
KFE80_09145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFE80_09150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KFE80_09165	COG0640	Transcriptional regulator
KFE80_09170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFE80_09175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KFE80_09180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KFE80_09195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFE80_09245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFE80_09260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KFE80_09265	COG1473	amidohydrolase
KFE80_09285	COG2992	FlgJ-related protein
KFE80_09295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KFE80_09310	COG0405	Gamma-glutamyltransferase
KFE80_09315	COG0471	metal ion transport
KFE80_09320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KFE80_09340	COG0534	Mate efflux family protein
KFE80_09345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFE80_09355	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KFE80_09380	COG1612	heme a metabolic process
KFE80_09385	COG0109	protoheme IX farnesyltransferase activity
KFE80_09390	COG1999	signal sequence binding
KFE80_09395	COG2197	response regulator
KFE80_09400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFE80_09405	COG1121	(ABC) transporter
KFE80_09410	COG0735	belongs to the Fur family
KFE80_09415	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KFE80_09420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFE80_09420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFE80_09425	COG5001	Diguanylate cyclase
KFE80_09425	COG4251	negative regulation of phosphorylation
KFE80_09425	COG3706	GGDEF domain
KFE80_09425	COG2203	Gaf domain
KFE80_09435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFE80_09440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFE80_09445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KFE80_09450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KFE80_09460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFE80_09465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFE80_09470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFE80_09480	COG0356	it plays a direct role in the translocation of protons across the membrane
KFE80_09490	COG1475	DNA binding
KFE80_09495	COG1192	Involved in chromosome partitioning
KFE80_09505	COG0445	tRNA wobble uridine modification
KFE80_09510	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KFE80_09520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KFE80_09525	COG0706	membrane insertase activity
KFE80_09530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFE80_09535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFE80_09545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFE80_09580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KFE80_09585	COG1842	Phage shock protein A
KFE80_09595	COG1983	PspC domain protein
KFE80_09625	COG0751	glycine-tRNA ligase activity
KFE80_09630	COG0752	glycyl-tRNA synthetase alpha subunit
KFE80_09685	COG1431	PFAM Stem cell self-renewal protein Piwi
KFE80_09690	COG1690	Belongs to the RtcB family
KFE80_09720	COG0668	transmembrane transport
KFE80_09740	COG3784	Protein of unknown function (DUF1318)
KFE80_09760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KFE80_09765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFE80_09770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KFE80_09770	COG0131	Imidazoleglycerol-phosphate dehydratase
KFE80_09775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFE80_09780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KFE80_09790	COG1522	sequence-specific DNA binding
KFE80_09795	COG1012	belongs to the aldehyde dehydrogenase family
KFE80_09815	COG1607	acyl-coa hydrolase
KFE80_09820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFE80_09835	COG0573	inorganic phosphate transmembrane transporter activity
KFE80_09845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFE80_09850	COG0704	Plays a role in the regulation of phosphate uptake
KFE80_09860	COG0501	Belongs to the peptidase M48B family
KFE80_09865	COG3022	response to hydroperoxide
KFE80_09900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KFE80_09920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KFE80_09925	COG0175	sulfate reduction
KFE80_09960	COG0393	Putative heavy-metal-binding
KFE80_09965	COG0393	Putative heavy-metal-binding
KFE80_09970	COG0501	Belongs to the peptidase M48B family
KFE80_09975	COG1301	dicarboxylic acid transport
KFE80_09985	COG0306	phosphate transporter
KFE80_09990	COG1392	Phosphate transport regulator
KFE80_09995	COG2207	Transcriptional regulator
KFE80_09995	COG1917	Cupin 2, conserved barrel domain protein
KFE80_10040	COG2165	general secretion pathway protein
KFE80_10045	COG1459	type II secretion system
KFE80_10050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFE80_10060	COG3409	Peptidoglycan-binding domain 1 protein
KFE80_10060	COG3267	Type II secretory pathway component ExeA
KFE80_10065	COG1450	Type ii and iii secretion system protein
KFE80_10090	COG1166	arginine decarboxylase activity
KFE80_10100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KFE80_10115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KFE80_10140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KFE80_10145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFE80_10150	COG2226	methyltransferase
KFE80_10155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KFE80_10160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KFE80_10185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KFE80_10190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KFE80_10195	COG0509	glycine decarboxylation via glycine cleavage system
KFE80_10200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KFE80_10210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KFE80_10215	COG0494	nUDIX hydrolase
KFE80_10225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFE80_10230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KFE80_10245	COG0811	peptide transport
KFE80_10250	COG0811	peptide transport
KFE80_10255	COG0848	biopolymer transport protein
KFE80_10270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFE80_10275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KFE80_10285	COG1519	Transferase
KFE80_10290	COG1538	Outer membrane efflux protein
KFE80_10295	COG3151	Protein conserved in bacteria
KFE80_10300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFE80_10305	COG3150	esterase
KFE80_10320	COG0668	transmembrane transport
KFE80_10325	COG2261	transglycosylase associated protein
KFE80_10340	COG4771	TonB-dependent receptor
KFE80_10345	COG4206	TonB-dependent receptor
KFE80_10350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KFE80_10380	COG1956	GAF domain-containing protein
KFE80_10385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFE80_10390	COG0745	RESPONSE REGULATOR receiver
KFE80_10400	COG0315	cyclic pyranopterin monophosphate synthase activity
KFE80_10405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KFE80_10410	COG0314	molybdopterin synthase activity
KFE80_10415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFE80_10420	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFE80_10425	COG0303	'Molybdopterin
KFE80_10435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE80_10440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFE80_10445	COG0488	(ABC) transporter
KFE80_10450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE80_10455	COG4232	protein-disulfide reductase activity
KFE80_10460	COG3590	peptidase
KFE80_10480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFE80_10500	COG0750	zinc metalloprotease
KFE80_10515	COG0204	Acyl-transferase
KFE80_10515	COG0318	PFAM AMP-dependent synthetase and ligase
KFE80_10555	COG2353	YceI-like domain
KFE80_10560	COG3038	cytochrome b561
KFE80_10565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KFE80_10570	COG0583	DNA-binding transcription factor activity
KFE80_10575	COG2314	TM2 domain
KFE80_10595	COG2095	MarC family integral membrane protein
KFE80_10600	COG1981	membrane
KFE80_10615	COG0316	Belongs to the HesB IscA family
KFE80_10625	COG0417	DNA replication proofreading
KFE80_10630	COG2855	membrane
KFE80_10635	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KFE80_10640	COG0739	heme binding
KFE80_10645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFE80_10675	COG0730	response to heat
KFE80_10680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KFE80_10680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KFE80_10685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KFE80_10730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFE80_10735	COG0081	regulation of translation
KFE80_10740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFE80_10745	COG0222	ribosome binding
KFE80_10750	COG0085	RNA polymerase activity
KFE80_10755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFE80_10760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFE80_10765	COG0049	tRNA binding
KFE80_10770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFE80_10775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFE80_10785	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KFE80_10860	COG0673	inositol 2-dehydrogenase activity
KFE80_10865	COG0297	glycogen (starch) synthase activity
KFE80_10905	COG1028	Short-chain dehydrogenase reductase Sdr
KFE80_10945	COG2076	Multidrug Resistance protein
KFE80_10950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KFE80_10970	COG0051	transcription antitermination factor activity, RNA binding
KFE80_10975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFE80_10980	COG0088	Forms part of the polypeptide exit tunnel
KFE80_10985	COG0089	rRNA binding
KFE80_10990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFE80_10995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFE80_11000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFE80_11005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFE80_11010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFE80_11020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFE80_11025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFE80_11030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFE80_11035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFE80_11040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFE80_11045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFE80_11050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFE80_11055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFE80_11065	COG1841	ribosomal large subunit assembly
KFE80_11070	COG0200	Binds to the 23S rRNA
KFE80_11080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFE80_11085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFE80_11090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFE80_11095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFE80_11100	COG0202	RNA polymerase activity
KFE80_11105	COG0203	ribosomal protein L17
KFE80_11120	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KFE80_11120	COG0662	Cupin 2, conserved barrel domain protein
KFE80_11125	COG0346	lactoylglutathione lyase activity
KFE80_11135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFE80_11135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFE80_11140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KFE80_11150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KFE80_11155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KFE80_11160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFE80_11165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KFE80_11175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KFE80_11190	COG1466	dna polymerase III delta subunit
KFE80_11200	COG0495	leucyl-tRNA aminoacylation
KFE80_11210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE80_11235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KFE80_11245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFE80_11250	COG1702	phosphate starvation-inducible protein PhoH
KFE80_11255	COG1522	sequence-specific DNA binding
KFE80_11265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFE80_11270	COG4452	Inner membrane protein CreD
KFE80_11305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFE80_11335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KFE80_11345	COG4181	ATPase activity
KFE80_11350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KFE80_11360	COG0596	Alpha beta hydrolase
KFE80_11380	COG0254	rRNA binding
KFE80_11385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFE80_11395	COG2860	membrane
KFE80_11400	COG0737	Belongs to the 5'-nucleotidase family
KFE80_11415	COG0625	glutathione transferase activity
KFE80_11425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFE80_11435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KFE80_11440	COG1194	a g-specific adenine glycosylase
KFE80_11465	COG0589	response to stress
KFE80_11470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KFE80_11500	COG1253	flavin adenine dinucleotide binding
KFE80_11520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KFE80_11545	COG1509	lysine 2,3-aminomutase activity
KFE80_11550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFE80_11560	COG1901	pseudouridine methyltransferase
KFE80_11570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KFE80_11575	COG0733	neurotransmitter:sodium symporter activity
KFE80_11580	COG3852	Histidine kinase
KFE80_11585	COG1858	cytochrome C peroxidase
KFE80_11590	COG4191	Histidine kinase
KFE80_11590	COG0784	Response regulator, receiver
KFE80_11595	COG2204	response regulator
KFE80_11605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE80_11610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFE80_11615	COG0154	amidase activity
KFE80_11620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFE80_11625	COG1077	Cell shape determining protein MreB Mrl
KFE80_11630	COG1792	Involved in formation and maintenance of cell shape
KFE80_11635	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KFE80_11640	COG0424	maF-like protein
KFE80_11655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFE80_11670	COG2959	enzyme of heme biosynthesis
KFE80_11700	COG0659	secondary active sulfate transmembrane transporter activity
KFE80_11705	COG2001	Belongs to the MraZ family
KFE80_11710	COG0275	rRNA processing
KFE80_11725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFE80_11730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KFE80_11735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFE80_11740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFE80_11745	COG0772	Belongs to the SEDS family
KFE80_11750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFE80_11755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFE80_11760	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFE80_11780	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KFE80_11785	COG0739	heme binding
KFE80_11790	COG0653	protein targeting
KFE80_11800	COG0494	nUDIX hydrolase
KFE80_11805	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KFE80_11810	COG0237	dephospho-CoA kinase activity
KFE80_11815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KFE80_11860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KFE80_11870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KFE80_11880	COG2022	thiamine diphosphate biosynthetic process
KFE80_11890	COG0352	thiamine-phosphate diphosphorylase activity
KFE80_11895	COG0288	reversible hydration of carbon dioxide
KFE80_11910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFE80_11915	COG1428	Deoxynucleoside kinase
KFE80_11935	COG3852	Histidine kinase
KFE80_11945	COG2814	Major facilitator Superfamily
KFE80_11950	COG0629	single-stranded DNA binding
KFE80_11980	COG0142	geranyltranstransferase activity
KFE80_11995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFE80_12000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFE80_12010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KFE80_12015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFE80_12020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFE80_12025	COG0723	plastoquinol--plastocyanin reductase activity
KFE80_12030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KFE80_12035	COG0625	glutathione transferase activity
KFE80_12040	COG2969	positive regulation of protein catabolic process
KFE80_12045	COG0183	Belongs to the thiolase family
KFE80_12070	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KFE80_12075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KFE80_12090	COG0523	cobalamin synthesis protein
KFE80_12095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFE80_12100	COG1469	GTP cyclohydrolase I activity
KFE80_12140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KFE80_12165	COG0557	exoribonuclease II activity
KFE80_12170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFE80_12180	COG1104	cysteine desulfurase activity
KFE80_12200	COG0714	Associated with various cellular activities
KFE80_12225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFE80_12230	COG0360	Binds together with S18 to 16S ribosomal RNA
KFE80_12235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFE80_12245	COG0359	binds to the 23S rRNA
KFE80_12250	COG0305	Participates in initiation and elongation during chromosome replication
KFE80_12255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KFE80_12260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KFE80_12265	COG5002	protein histidine kinase activity
KFE80_12290	COG1028	Short-chain dehydrogenase reductase Sdr
KFE80_12295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KFE80_12325	COG0678	peroxiredoxin activity
KFE80_12330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFE80_12340	COG1489	DNA binding
KFE80_12345	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFE80_12365	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KFE80_12370	COG4651	solute:proton antiporter activity
KFE80_12370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFE80_12380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFE80_12385	COG0564	pseudouridine synthase activity
KFE80_12400	COG0606	chelatase, subunit chli
KFE80_12410	COG0347	Belongs to the P(II) protein family
KFE80_12435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KFE80_12445	COG1965	Belongs to the frataxin family
KFE80_12460	COG3275	phosphorelay sensor kinase activity
KFE80_12475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KFE80_12480	COG0792	nuclease activity
KFE80_12510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFE80_12515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KFE80_12520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KFE80_12525	COG1011	Hydrolase
KFE80_12565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFE80_12570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFE80_12575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFE80_12585	COG0688	phosphatidylethanolamine metabolic process
KFE80_12595	COG1162	GTPase activity
KFE80_12605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KFE80_12615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KFE80_12615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFE80_12620	COG0802	atpase or kinase
KFE80_12625	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFE80_12630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFE80_12635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFE80_12640	COG1923	regulation of RNA biosynthetic process
KFE80_12645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFE80_12650	COG0330	HflC and HflK could
KFE80_12655	COG0330	HflC and HflK could
KFE80_12665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFE80_12670	COG2895	sulfate adenylyltransferase (ATP) activity
KFE80_12675	COG0175	sulfate reduction
KFE80_12680	COG1045	serine acetyltransferase
KFE80_12685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KFE80_12690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFE80_12700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KFE80_12700	COG1648	precorrin-2 dehydrogenase activity
KFE80_12710	COG0564	pseudouridine synthase activity
KFE80_12725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFE80_12725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFE80_12735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFE80_12740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFE80_12750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFE80_12755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KFE80_12775	COG3220	belongs to the UPF0276 family
KFE80_12795	COG0531	amino acid
KFE80_12800	COG4771	TonB-dependent receptor
KFE80_12805	COG1505	serine-type exopeptidase activity
KFE80_12820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KFE80_12840	COG1183	phosphatidylcholine synthase activity
KFE80_12845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFE80_12895	COG1595	DNA-templated transcription, initiation
KFE80_12900	COG2304	oxidoreductase activity
KFE80_12915	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KFE80_12920	COG2205	protein histidine kinase activity
KFE80_12925	COG4206	TonB-dependent receptor
KFE80_12925	COG4206	TonB-dependent receptor
KFE80_12930	COG0318	PFAM AMP-dependent synthetase and ligase
KFE80_12935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE80_12970	COG2319	Wd-40 repeat
KFE80_12975	COG2319	Wd-40 repeat
KFE80_12995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFE80_13030	COG2862	Uncharacterized protein family, UPF0114
KFE80_13055	COG0017	Asparaginyl-tRNA synthetase
KFE80_13075	COG3813	Protein conserved in bacteria
KFE80_13080	COG0596	Alpha beta hydrolase
KFE80_13090	COG4660	Part of a membrane complex involved in electron transport
KFE80_13095	COG4659	FMN binding
KFE80_13100	COG4658	electron transport chain
KFE80_13110	COG2878	Part of a membrane complex involved in electron transport
KFE80_13115	COG4657	Part of a membrane complex involved in electron transport
KFE80_13150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE80_13195	COG1309	transcriptional regulator
KFE80_13200	COG1454	alcohol dehydrogenase
KFE80_13215	COG0789	Transcriptional regulator
KFE80_13245	COG0494	nUDIX hydrolase
KFE80_13260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KFE80_13265	COG0217	transcriptional regulatory protein
KFE80_13275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KFE80_13280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KFE80_13285	COG0142	geranyltranstransferase activity
KFE80_13305	COG0733	neurotransmitter:sodium symporter activity
KFE80_13315	COG1012	belongs to the aldehyde dehydrogenase family
KFE80_13320	COG1639	'signal transduction protein
KFE80_13365	COG3720	iron ion transport
KFE80_13370	COG4558	Periplasmic binding protein
KFE80_13375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFE80_13380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KFE80_13385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFE80_13390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFE80_13395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KFE80_13400	COG0450	alkyl hydroperoxide reductase
KFE80_13410	COG1073	alpha beta
KFE80_13420	COG0280	phosphate acetyltransferase
KFE80_13420	COG0281	malic enzyme
KFE80_13425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFE80_13430	COG0418	dihydroorotase activity
KFE80_13435	COG3278	Belongs to the heme-copper respiratory oxidase family
KFE80_13450	COG2010	Cytochrome c
KFE80_13495	COG0405	Gamma-glutamyltransferase
KFE80_13515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFE80_13520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity