locus-tag	class	description
KFE98_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFE98_00035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KFE98_00055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KFE98_00060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFE98_00070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KFE98_00085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFE98_00090	COG1702	phosphate starvation-inducible protein PhoH
KFE98_00135	COG2972	Histidine kinase
KFE98_00140	COG3279	Response regulator of the LytR AlgR family
KFE98_00160	COG2363	Small membrane protein
KFE98_00165	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFE98_00175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFE98_00185	COG0569	domain protein
KFE98_00195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFE98_00215	COG2986	histidine ammonia-lyase
KFE98_00220	COG0124	histidyl-tRNA synthetase
KFE98_00225	COG0488	(ABC) transporter
KFE98_00230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KFE98_00240	COG0189	ligase activity
KFE98_00260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KFE98_00335	COG0439	Biotin carboxylase
KFE98_00345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KFE98_00360	COG1442	glycosyl transferase family 8
KFE98_00360	COG1216	Glycosyl transferase, family 2
KFE98_00405	COG0037	tRNA processing
KFE98_00435	COG0604	alcohol dehydrogenase
KFE98_00480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KFE98_00510	COG0352	thiamine-phosphate diphosphorylase activity
KFE98_00510	COG0351	phosphomethylpyrimidine kinase
KFE98_00515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KFE98_00520	COG0352	thiamine-phosphate diphosphorylase activity
KFE98_00525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KFE98_00555	COG3104	oligopeptide transport
KFE98_00570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KFE98_00575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KFE98_00590	COG2095	MarC family integral membrane protein
KFE98_00605	COG1404	Belongs to the peptidase S8 family
KFE98_00615	COG1404	Belongs to the peptidase S8 family
KFE98_00625	COG0778	Nitroreductase
KFE98_00635	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KFE98_00640	COG0714	Associated with various cellular activities
KFE98_00645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFE98_00655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFE98_00660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFE98_00665	COG0517	IMP dehydrogenase activity
KFE98_00665	COG0516	GMP reductase activity
KFE98_00680	COG1216	Glycosyl transferase, family 2
KFE98_00695	COG0367	asparagine synthase
KFE98_00705	COG0471	metal ion transport
KFE98_00705	COG3273	potassium ion transport
KFE98_00710	COG0529	Catalyzes the synthesis of activated sulfate
KFE98_00715	COG0175	sulfate reduction
KFE98_00740	COG0297	glycogen (starch) synthase activity
KFE98_00740	COG0438	transferase activity, transferring glycosyl groups
KFE98_00745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFE98_00755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFE98_00805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_00810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KFE98_00820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE98_00835	COG1132	(ABC) transporter
KFE98_00885	COG0247	lactate metabolic process
KFE98_00885	COG2181	nitrate reductase activity
KFE98_00895	COG2181	nitrate reductase activity
KFE98_00895	COG0247	lactate metabolic process
KFE98_00905	COG0860	N-Acetylmuramoyl-L-alanine amidase
KFE98_00910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KFE98_00925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFE98_00930	COG0367	asparagine synthase
KFE98_00945	COG3206	protein involved in exopolysaccharide biosynthesis
KFE98_00945	COG0489	protein tyrosine kinase activity
KFE98_00955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFE98_00965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KFE98_00995	COG0653	protein targeting
KFE98_01005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFE98_01050	COG1506	peptidase
KFE98_01050	COG0823	Involved in the tonB-independent uptake of proteins
KFE98_01060	COG1476	TRANSCRIPTIONal
KFE98_01115	COG0386	Belongs to the glutathione peroxidase family
KFE98_01120	COG1846	Transcriptional regulator
KFE98_01205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFE98_01230	COG2226	methyltransferase
KFE98_01240	COG3275	phosphorelay sensor kinase activity
KFE98_01275	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_01280	COG4977	sequence-specific DNA binding
KFE98_01280	COG1917	Cupin 2, conserved barrel domain protein
KFE98_01315	COG1733	regulation of RNA biosynthetic process
KFE98_01325	COG2972	Histidine kinase
KFE98_01340	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_01345	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_01355	COG2207	Transcriptional regulator
KFE98_01355	COG4753	response regulator
KFE98_01365	COG2169	Transcriptional regulator
KFE98_01365	COG1917	Cupin 2, conserved barrel domain protein
KFE98_01375	COG1733	regulation of RNA biosynthetic process
KFE98_01380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KFE98_01395	COG2197	response regulator
KFE98_01410	COG0688	phosphatidylethanolamine metabolic process
KFE98_01415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFE98_01455	COG2197	response regulator
KFE98_01465	COG4977	sequence-specific DNA binding
KFE98_01465	COG1917	Cupin 2, conserved barrel domain protein
KFE98_01550	COG0596	Alpha beta hydrolase
KFE98_01765	COG0305	Participates in initiation and elongation during chromosome replication
KFE98_01780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFE98_01785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KFE98_01800	COG0572	uridine kinase
KFE98_01805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFE98_01810	COG1490	D-aminoacyl-tRNA deacylase activity
KFE98_01830	COG0519	Catalyzes the synthesis of GMP from XMP
KFE98_01840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KFE98_01845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KFE98_01850	COG0196	riboflavin kinase activity
KFE98_01910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFE98_01915	COG1185	polyribonucleotide nucleotidyltransferase activity
KFE98_01920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFE98_01925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFE98_01930	COG1830	Aldolase
KFE98_01940	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KFE98_01970	COG3781	membrane
KFE98_01985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFE98_01990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KFE98_01995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFE98_02000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFE98_02005	COG1454	alcohol dehydrogenase
KFE98_02020	COG0248	Ppx GppA phosphatase
KFE98_02040	COG0442	prolyl-tRNA aminoacylation
KFE98_02085	COG3275	phosphorelay sensor kinase activity
KFE98_02110	COG2226	methyltransferase
KFE98_02170	COG0187	DNA topoisomerase II activity
KFE98_02185	COG2884	Cell division ATP-binding protein ftsE
KFE98_02200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFE98_02200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_02210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KFE98_02215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_02220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KFE98_02230	COG1295	ribonuclease BN
KFE98_02245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFE98_02260	COG2270	Major facilitator Superfamily
KFE98_02275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFE98_02290	COG0825	malonyl-CoA metabolic process
KFE98_02295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KFE98_02305	COG0343	queuine tRNA-ribosyltransferase activity
KFE98_02315	COG1595	DNA-templated transcription, initiation
KFE98_02320	COG0357	Ribosomal RNA small subunit methyltransferase G
KFE98_02335	COG1132	(ABC) transporter
KFE98_02350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KFE98_02355	COG0579	oxidoreductase
KFE98_02365	COG2045	Belongs to the ComB family
KFE98_02385	COG0584	glycerophosphoryl diester phosphodiesterase
KFE98_02425	COG0438	transferase activity, transferring glycosyl groups
KFE98_02435	COG0367	asparagine synthase
KFE98_02445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KFE98_02455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KFE98_02470	COG1138	Cytochrome C-type biogenesis protein
KFE98_02480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KFE98_02490	COG0424	maF-like protein
KFE98_02510	COG0671	phosphoesterase, PA-phosphatase related
KFE98_02515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFE98_02520	COG0563	adenylate kinase activity
KFE98_02530	COG0643	Histidine kinase
KFE98_02530	COG0784	Response regulator, receiver
KFE98_02530	COG2198	Histidine kinase
KFE98_02535	COG0823	Involved in the tonB-independent uptake of proteins
KFE98_02535	COG1506	peptidase
KFE98_02700	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_02720	COG5507	3-demethylubiquinone-9 3-methyltransferase
KFE98_02785	COG1595	DNA-templated transcription, initiation
KFE98_02805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KFE98_02805	COG1333	cytochrome c biogenesis protein
KFE98_02810	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KFE98_02815	COG3005	denitrification pathway
KFE98_02845	COG0339	signal peptide processing
KFE98_02875	COG3279	Response regulator of the LytR AlgR family
KFE98_02880	COG2972	Histidine kinase
KFE98_02910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFE98_02920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KFE98_03015	COG3275	phosphorelay sensor kinase activity
KFE98_03025	COG3275	phosphorelay sensor kinase activity
KFE98_03030	COG3279	Response regulator of the LytR AlgR family
KFE98_03045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFE98_03065	COG3292	Two component regulator propeller
KFE98_03065	COG2205	protein histidine kinase activity
KFE98_03065	COG0745	RESPONSE REGULATOR receiver
KFE98_03065	COG3292	Two component regulator propeller
KFE98_03065	COG2205	protein histidine kinase activity
KFE98_03065	COG0745	RESPONSE REGULATOR receiver
KFE98_03080	COG0784	Response regulator, receiver
KFE98_03120	COG4771	TonB-dependent receptor
KFE98_03140	COG2132	Multicopper oxidase
KFE98_03150	COG1858	cytochrome C peroxidase
KFE98_03155	COG1858	cytochrome C peroxidase
KFE98_03250	COG3275	phosphorelay sensor kinase activity
KFE98_03255	COG3279	Response regulator of the LytR AlgR family
KFE98_03290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFE98_03325	COG0702	epimerase
KFE98_03345	COG0450	alkyl hydroperoxide reductase
KFE98_03360	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_03395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFE98_03395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFE98_03405	COG0861	Integral membrane protein TerC family
KFE98_03420	COG3022	response to hydroperoxide
KFE98_03430	COG0494	nUDIX hydrolase
KFE98_03520	COG0022	dehydrogenase e1 component
KFE98_03545	COG0438	transferase activity, transferring glycosyl groups
KFE98_03550	COG1472	Belongs to the glycosyl hydrolase 3 family
KFE98_03570	COG3279	Response regulator of the LytR AlgR family
KFE98_03575	COG3275	phosphorelay sensor kinase activity
KFE98_03585	COG0492	ferredoxin-NADP+ reductase activity
KFE98_03610	COG0436	Aminotransferase
KFE98_03615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KFE98_03615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KFE98_03620	COG2226	methyltransferase
KFE98_03630	COG1846	Transcriptional regulator
KFE98_03635	COG1024	Enoyl-CoA hydratase
KFE98_03635	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFE98_03640	COG0183	Belongs to the thiolase family
KFE98_03645	COG1960	acyl-CoA dehydrogenase activity
KFE98_03650	COG0513	Belongs to the DEAD box helicase family
KFE98_03675	COG0148	phosphopyruvate hydratase activity
KFE98_03680	COG0505	Belongs to the CarA family
KFE98_03685	COG0203	ribosomal protein L17
KFE98_03690	COG0202	RNA polymerase activity
KFE98_03695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFE98_03700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KFE98_03705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFE98_03710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFE98_03715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KFE98_03725	COG0201	protein transport
KFE98_03730	COG0200	Binds to the 23S rRNA
KFE98_03735	COG1841	ribosomal large subunit assembly
KFE98_03740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFE98_03745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFE98_03750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFE98_03755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KFE98_03760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFE98_03765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFE98_03770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFE98_03775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFE98_03780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFE98_03785	COG0255	Belongs to the universal ribosomal protein uL29 family
KFE98_03790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFE98_03795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFE98_03800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KFE98_03805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFE98_03810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KFE98_03815	COG0089	rRNA binding
KFE98_03820	COG0088	Forms part of the polypeptide exit tunnel
KFE98_03825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFE98_03830	COG0051	transcription antitermination factor activity, RNA binding
KFE98_03835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFE98_03840	COG0049	tRNA binding
KFE98_03845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFE98_03860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFE98_03865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE98_03870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFE98_03875	COG0484	heat shock protein binding
KFE98_03880	COG4152	abc transporter atp-binding protein
KFE98_03885	COG1668	transmembrane transport
KFE98_03915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KFE98_03920	COG0739	heme binding
KFE98_03930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_03940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KFE98_03970	COG0606	chelatase, subunit chli
KFE98_03985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFE98_03995	COG0686	Belongs to the AlaDH PNT family
KFE98_04000	COG0802	atpase or kinase
KFE98_04010	COG1078	dGTPase activity
KFE98_04015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFE98_04020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KFE98_04020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFE98_04035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFE98_04040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFE98_04080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KFE98_04080	COG0674	pyruvate-flavodoxin oxidoreductase activity
KFE98_04085	COG1013	pyruvate-flavodoxin oxidoreductase activity
KFE98_04100	COG1770	oligopeptidase
KFE98_04105	COG0113	porphobilinogen synthase activity
KFE98_04115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFE98_04150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE98_04160	COG0275	rRNA processing
KFE98_04195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KFE98_04220	COG0488	(ABC) transporter
KFE98_04235	COG1162	GTPase activity
KFE98_04240	COG1131	(ABC) transporter
KFE98_04250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFE98_04255	COG2010	Cytochrome c
KFE98_04260	COG4263	nitrous-oxide reductase activity
KFE98_04305	COG4221	oxidoreductase activity
KFE98_04310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFE98_04315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KFE98_04335	COG2197	response regulator
KFE98_04340	COG1166	arginine decarboxylase activity
KFE98_04350	COG0577	efflux transmembrane transporter activity
KFE98_04350	COG1136	(ABC) transporter
KFE98_04355	COG0577	efflux transmembrane transporter activity
KFE98_04355	COG1136	(ABC) transporter
KFE98_04375	COG1309	transcriptional regulator
KFE98_04380	COG1446	asparaginase
KFE98_04385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KFE98_04390	COG0463	Glycosyl transferase, family 2
KFE98_04470	COG0641	radical SAM
KFE98_04505	COG1032	radical SAM domain protein
KFE98_04515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFE98_04525	COG2715	membrane protein required for spore maturation
KFE98_04535	COG0009	L-threonylcarbamoyladenylate synthase
KFE98_04540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KFE98_04545	COG5002	protein histidine kinase activity
KFE98_04555	COG1331	Highly conserved protein containing a thioredoxin domain
KFE98_04605	COG1214	PFAM Peptidase M22, glycoprotease
KFE98_04625	COG0646	methionine synthase
KFE98_04625	COG1410	methionine synthase
KFE98_04645	COG2322	membrane
KFE98_04665	COG1845	cytochrome c oxidase, subunit III
KFE98_04670	COG0109	protoheme IX farnesyltransferase activity
KFE98_04675	COG0109	protoheme IX farnesyltransferase activity
KFE98_04685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFE98_04695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_04700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KFE98_04710	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_04720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KFE98_04730	COG0509	glycine decarboxylation via glycine cleavage system
KFE98_04745	COG0632	four-way junction helicase activity
KFE98_04750	COG0281	malic enzyme
KFE98_04750	COG0280	phosphate acetyltransferase
KFE98_04755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KFE98_04780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFE98_04785	COG2255	four-way junction helicase activity
KFE98_04790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFE98_04795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFE98_04820	COG0437	4 iron, 4 sulfur cluster binding
KFE98_04840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KFE98_04845	COG0195	Participates in both transcription termination and antitermination
KFE98_04850	COG0779	Required for maturation of 30S ribosomal subunits
KFE98_04915	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_04955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFE98_04955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFE98_04960	COG1619	proteins homologs of microcin C7 resistance protein MccF
KFE98_04980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KFE98_04985	COG0702	epimerase
KFE98_04990	COG4953	penicillin-binding protein 1C
KFE98_05025	COG1187	pseudouridine synthase activity
KFE98_05030	COG0792	nuclease activity
KFE98_05060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KFE98_05065	COG0653	protein targeting
KFE98_05090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFE98_05090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KFE98_05105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFE98_05110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KFE98_05130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KFE98_05135	COG0142	geranyltranstransferase activity
KFE98_05150	COG1090	epimerase
KFE98_05165	COG2972	Histidine kinase
KFE98_05170	COG3279	Response regulator of the LytR AlgR family
KFE98_05175	COG3279	Response regulator of the LytR AlgR family
KFE98_05180	COG0590	tRNA wobble adenosine to inosine editing
KFE98_05200	COG0233	cytoplasmic translational termination
KFE98_05205	COG0528	UMP kinase activity
KFE98_05210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFE98_05215	COG0052	Belongs to the universal ribosomal protein uS2 family
KFE98_05220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFE98_05225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFE98_05245	COG0303	'Molybdopterin
KFE98_05250	COG0746	molybdenum cofactor guanylyltransferase activity
KFE98_05300	COG1690	Belongs to the RtcB family
KFE98_05385	COG4565	transcriptional regulatory protein
KFE98_05405	COG1696	Membrane protein involved in D-alanine export
KFE98_05425	COG1309	transcriptional regulator
KFE98_05435	COG2814	Major facilitator Superfamily
KFE98_05470	COG2972	Histidine kinase
KFE98_05475	COG3279	Response regulator of the LytR AlgR family
KFE98_05490	COG1741	Belongs to the pirin family
KFE98_05525	COG0688	phosphatidylethanolamine metabolic process
KFE98_05535	COG0596	Alpha beta hydrolase
KFE98_05555	COG1122	ATPase activity
KFE98_05565	COG1999	signal sequence binding
KFE98_05600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFE98_05615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KFE98_05620	COG3844	kynureninase activity
KFE98_05625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFE98_05655	COG0745	RESPONSE REGULATOR receiver
KFE98_05660	COG5002	protein histidine kinase activity
KFE98_05680	COG3321	synthase
KFE98_05680	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_05680	COG0604	alcohol dehydrogenase
KFE98_05715	COG0577	efflux transmembrane transporter activity
KFE98_05715	COG1136	(ABC) transporter
KFE98_05720	COG1136	(ABC) transporter
KFE98_05720	COG0577	efflux transmembrane transporter activity
KFE98_05725	COG1024	Enoyl-CoA hydratase
KFE98_05730	COG5000	phosphorelay sensor kinase activity
KFE98_05750	COG0644	oxidoreductase
KFE98_05760	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_05765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KFE98_05770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFE98_05785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFE98_05790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFE98_05810	COG1131	(ABC) transporter
KFE98_05875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFE98_05880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KFE98_05905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFE98_05930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFE98_05950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KFE98_05980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFE98_05990	COG2239	Acts as a magnesium transporter
KFE98_05995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KFE98_06015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KFE98_06020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KFE98_06025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KFE98_06035	COG0697	spore germination
KFE98_06040	COG1136	(ABC) transporter
KFE98_06050	COG1127	ABC transporter
KFE98_06055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KFE98_06085	COG1393	Belongs to the ArsC family
KFE98_06105	COG1530	ribonuclease E activity
KFE98_06115	COG0776	regulation of translation
KFE98_06125	COG0629	single-stranded DNA binding
KFE98_06140	COG1612	heme a metabolic process
KFE98_06150	COG0805	protein transport
KFE98_06160	COG1137	ATPase activity
KFE98_06190	COG0513	Belongs to the DEAD box helicase family
KFE98_06195	COG3239	Fatty acid desaturase
KFE98_06210	COG5002	protein histidine kinase activity
KFE98_06215	COG2197	response regulator
KFE98_06230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFE98_06250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KFE98_06275	COG1253	flavin adenine dinucleotide binding
KFE98_06280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFE98_06290	COG0495	leucyl-tRNA aminoacylation
KFE98_06295	COG2177	Part of the ABC transporter FtsEX involved in
KFE98_06305	COG1968	undecaprenyl-diphosphatase activity
KFE98_06310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFE98_06315	COG3852	Histidine kinase
KFE98_06320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFE98_06335	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_06370	COG0126	phosphoglycerate kinase activity
KFE98_06380	COG1774	PSP1 C-terminal conserved region
KFE98_06390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KFE98_06395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KFE98_06400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFE98_06405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFE98_06410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFE98_06415	COG0356	it plays a direct role in the translocation of protons across the membrane
KFE98_06430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFE98_06435	COG0154	amidase activity
KFE98_06460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFE98_06480	COG1733	regulation of RNA biosynthetic process
KFE98_06485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFE98_06515	COG1733	regulation of RNA biosynthetic process
KFE98_06520	COG0596	Alpha beta hydrolase
KFE98_06545	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KFE98_06595	COG2814	Major facilitator Superfamily
KFE98_06620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFE98_06630	COG0180	Tryptophanyl-tRNA synthetase
KFE98_06645	COG1595	DNA-templated transcription, initiation
KFE98_06655	COG1981	membrane
KFE98_06660	COG1607	acyl-coa hydrolase
KFE98_06680	COG4942	peptidase
KFE98_06685	COG0439	Biotin carboxylase
KFE98_06690	COG0511	ligase activity, forming carbon-carbon bonds
KFE98_06695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFE98_06700	COG0416	fatty acid biosynthetic process
KFE98_06705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFE98_06720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KFE98_06725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFE98_06730	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KFE98_06735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KFE98_06750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_06755	COG2234	aminopeptidase activity
KFE98_06775	COG0328	RNA-DNA hybrid ribonuclease activity
KFE98_06780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KFE98_06790	COG3118	belongs to the thioredoxin family
KFE98_06805	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KFE98_06805	COG0778	Nitroreductase
KFE98_06815	COG0668	transmembrane transport
KFE98_06860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KFE98_06870	COG0181	hydroxymethylbilane synthase activity
KFE98_06875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFE98_06930	COG0848	biopolymer transport protein
KFE98_06940	COG0811	peptide transport
KFE98_06955	COG0252	asparaginase activity
KFE98_06960	COG0084	hydrolase, TatD family'
KFE98_06975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFE98_06975	COG0758	DNA mediated transformation
KFE98_06980	COG3264	Mechanosensitive ion channel
KFE98_06980	COG1196	nuclear chromosome segregation
KFE98_06990	COG3781	membrane
KFE98_07025	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_07045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KFE98_07075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE98_07080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KFE98_07085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KFE98_07090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFE98_07100	COG0445	tRNA wobble uridine modification
KFE98_07105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KFE98_07120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFE98_07135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KFE98_07145	COG0698	ribose 5-phosphate isomerase
KFE98_07165	COG0535	radical SAM domain protein
KFE98_07170	COG1528	Iron-storage protein
KFE98_07175	COG0557	exoribonuclease II activity
KFE98_07180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFE98_07180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFE98_07200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KFE98_07230	COG0437	4 iron, 4 sulfur cluster binding
KFE98_07245	COG1741	Belongs to the pirin family
KFE98_07250	COG0778	Nitroreductase
KFE98_07265	COG2197	response regulator
KFE98_07285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFE98_07305	COG0110	maltose O-acetyltransferase activity
KFE98_07340	COG2204	response regulator
KFE98_07345	COG0784	Response regulator, receiver
KFE98_07345	COG5002	protein histidine kinase activity
KFE98_07345	COG2198	Histidine kinase
KFE98_07355	COG2204	response regulator
KFE98_07390	COG1509	lysine 2,3-aminomutase activity
KFE98_07405	COG2205	protein histidine kinase activity
KFE98_07405	COG3292	Two component regulator propeller
KFE98_07405	COG0745	RESPONSE REGULATOR receiver
KFE98_07450	COG0488	(ABC) transporter
KFE98_07465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KFE98_07480	COG1846	Transcriptional regulator
KFE98_07500	COG0512	Glutamine amidotransferase of anthranilate synthase
KFE98_07525	COG2972	Histidine kinase
KFE98_07570	COG0076	glutamate decarboxylase activity
KFE98_07610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFE98_07630	COG3876	Protein conserved in bacteria
KFE98_07635	COG2755	lipolytic protein G-D-S-L family
KFE98_07635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KFE98_07640	COG1472	Belongs to the glycosyl hydrolase 3 family
KFE98_07660	COG4585	Histidine kinase
KFE98_07665	COG2197	response regulator
KFE98_07675	COG0745	RESPONSE REGULATOR receiver
KFE98_07675	COG2972	Histidine kinase
KFE98_07680	COG3279	Response regulator of the LytR AlgR family
KFE98_07700	COG1011	Hydrolase
KFE98_07745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFE98_07755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KFE98_07755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFE98_07780	COG2081	HI0933 family
KFE98_07795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KFE98_07795	COG3264	Mechanosensitive ion channel
KFE98_07800	COG0358	DNA primase activity
KFE98_07825	COG0741	lytic transglycosylase activity
KFE98_07835	COG1381	Involved in DNA repair and RecF pathway recombination
KFE98_07845	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_07850	COG0626	cystathionine gamma-synthase activity
KFE98_07870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KFE98_07895	COG3001	Fructosamine kinase
KFE98_07920	COG0823	Involved in the tonB-independent uptake of proteins
KFE98_07920	COG1506	peptidase
KFE98_07940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFE98_07965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFE98_08015	COG2378	regulation of single-species biofilm formation
KFE98_08020	COG4585	Histidine kinase
KFE98_08025	COG2197	response regulator
KFE98_08045	COG0300	oxidoreductase activity
KFE98_08050	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_08065	COG0778	Nitroreductase
KFE98_08070	COG1979	alcohol dehydrogenase
KFE98_08085	COG3851	Histidine kinase
KFE98_08090	COG2197	response regulator
KFE98_08125	COG3409	Peptidoglycan-binding domain 1 protein
KFE98_08125	COG3757	hydrolase, family 25
KFE98_08240	COG2197	response regulator
KFE98_08260	COG4912	Dna alkylation repair
KFE98_08270	COG3275	phosphorelay sensor kinase activity
KFE98_08275	COG3279	Response regulator of the LytR AlgR family
KFE98_08300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFE98_08305	COG4589	Belongs to the CDS family
KFE98_08325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KFE98_08340	COG4221	oxidoreductase activity
KFE98_08350	COG0859	PFAM glycosyl transferase family 9
KFE98_08360	COG1595	DNA-templated transcription, initiation
KFE98_08385	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KFE98_08395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KFE98_08415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KFE98_08435	COG3483	tryptophan 2,3-dioxygenase activity
KFE98_08450	COG0469	pyruvate kinase activity
KFE98_08460	COG0571	ribonuclease III activity
KFE98_08465	COG0571	ribonuclease III activity
KFE98_08470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KFE98_08475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KFE98_08480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFE98_08490	COG0322	excinuclease ABC activity
KFE98_08495	COG2205	protein histidine kinase activity
KFE98_08525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KFE98_08530	COG0017	Asparaginyl-tRNA synthetase
KFE98_08570	COG0037	tRNA processing
KFE98_08585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFE98_08585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFE98_08605	COG0471	metal ion transport
KFE98_08620	COG0427	acetyl-CoA hydrolase
KFE98_08625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFE98_08630	COG0194	GDP metabolic process
KFE98_08635	COG1561	YicC-like family, N-terminal region
KFE98_08685	COG0511	ligase activity, forming carbon-carbon bonds
KFE98_08705	COG2222	sugar isomerase
KFE98_08710	COG0321	lipoyl(octanoyl) transferase activity
KFE98_08730	COG0793	Belongs to the peptidase S41A family
KFE98_08735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFE98_08740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KFE98_08745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFE98_08750	COG0142	geranyltranstransferase activity
KFE98_08755	COG1960	acyl-CoA dehydrogenase activity
KFE98_08790	COG0594	ribonuclease P activity
KFE98_08795	COG0793	Belongs to the peptidase S41A family
KFE98_08820	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFE98_08830	COG2972	Histidine kinase
KFE98_08865	COG0138	bifunctional purine biosynthesis protein purh
KFE98_08885	COG0768	penicillin binding
KFE98_08890	COG0772	Belongs to the SEDS family
KFE98_08895	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFE98_08935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFE98_08940	COG1705	Flagellar rod assembly protein muramidase FlgJ
KFE98_08960	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KFE98_08995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFE98_09020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KFE98_09030	COG1435	thymidine kinase activity
KFE98_09035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFE98_09050	COG0739	heme binding
KFE98_09055	COG0242	peptide deformylase activity
KFE98_09065	COG1040	competence protein
KFE98_09075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KFE98_09085	COG0316	Belongs to the HesB IscA family
KFE98_09090	COG0719	Fe-S assembly protein
KFE98_09100	COG0396	ATPase activity
KFE98_09105	COG0719	Fe-S assembly protein
KFE98_09110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFE98_09115	COG2166	iron-sulfur cluster assembly
KFE98_09120	COG2151	metal-sulfur cluster biosynthetic enzyme
KFE98_09130	COG3275	phosphorelay sensor kinase activity
KFE98_09150	COG0006	proline dipeptidase activity
KFE98_09165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KFE98_09170	COG0436	Aminotransferase
KFE98_09185	COG1956	GAF domain-containing protein
KFE98_09220	COG2204	response regulator
KFE98_09235	COG1132	(ABC) transporter
KFE98_09240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KFE98_09245	COG4591	ABC-type transport system involved in lipoprotein release permease component
KFE98_09255	COG0460	homoserine dehydrogenase
KFE98_09255	COG0527	aspartate kinase activity
KFE98_09280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFE98_09285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KFE98_09305	COG1183	phosphatidylcholine synthase activity
KFE98_09320	COG0193	aminoacyl-tRNA hydrolase activity
KFE98_09325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFE98_09330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFE98_09340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KFE98_09385	COG1610	YqeY-like protein
KFE98_09390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFE98_09405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFE98_09410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFE98_09415	COG0772	Belongs to the SEDS family
KFE98_09420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFE98_09425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFE98_09430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFE98_09435	COG0768	penicillin binding
KFE98_09445	COG0275	rRNA processing
KFE98_09450	COG2001	Belongs to the MraZ family
KFE98_09460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFE98_09480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KFE98_09490	COG0205	6-phosphofructokinase activity
KFE98_09505	COG4771	TonB-dependent receptor
KFE98_09510	COG0481	GTPase activity
KFE98_09520	COG1131	(ABC) transporter
KFE98_09525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KFE98_09530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KFE98_09555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KFE98_09570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KFE98_09580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KFE98_09625	COG0463	Glycosyl transferase, family 2
KFE98_09630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFE98_09665	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
KFE98_09685	COG1051	belongs to the nudix hydrolase family
KFE98_09695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KFE98_09735	COG0848	biopolymer transport protein
KFE98_09740	COG0811	peptide transport
KFE98_09750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KFE98_09755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KFE98_09760	COG1960	acyl-CoA dehydrogenase activity
KFE98_09765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFE98_09780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KFE98_09790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KFE98_09805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFE98_09815	COG0297	glycogen (starch) synthase activity
KFE98_09820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KFE98_09825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KFE98_09835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KFE98_09835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KFE98_09840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KFE98_09850	COG0423	glycine-tRNA ligase activity
KFE98_09855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KFE98_09860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFE98_09885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KFE98_09895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFE98_09905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KFE98_09910	COG4221	oxidoreductase activity
KFE98_09915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFE98_09925	COG0489	protein tyrosine kinase activity
KFE98_09930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFE98_09940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KFE98_09955	COG0459	protein refolding
KFE98_09960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFE98_09985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFE98_10010	COG0515	serine threonine protein kinase
KFE98_10010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFE98_10045	COG1088	dTDP-glucose 4,6-dehydratase activity
KFE98_10050	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KFE98_10060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_10065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KFE98_10085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFE98_10115	COG0544	peptidyl-prolyl cis-trans isomerase activity
KFE98_10125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFE98_10130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KFE98_10135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KFE98_10145	COG1404	Belongs to the peptidase S8 family
KFE98_10150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFE98_10160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KFE98_10165	COG2086	electron transfer activity
KFE98_10170	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFE98_10170	COG0022	dehydrogenase e1 component
KFE98_10190	COG1428	Deoxynucleoside kinase
KFE98_10205	COG0616	signal peptide processing
KFE98_10210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFE98_10210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KFE98_10215	COG1428	Deoxynucleoside kinase
KFE98_10295	COG3275	phosphorelay sensor kinase activity
KFE98_10325	COG0714	Associated with various cellular activities
KFE98_10365	COG3781	membrane
KFE98_10390	COG1917	Cupin 2, conserved barrel domain protein
KFE98_10390	COG4977	sequence-specific DNA binding
KFE98_10405	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_10440	COG2201	protein-glutamate methylesterase activity
KFE98_10485	COG4251	negative regulation of phosphorylation
KFE98_10575	COG2249	NAD(P)H dehydrogenase (quinone) activity
KFE98_10660	COG2354	Protein conserved in bacteria
KFE98_10675	COG1217	gtp-binding protein TYPA
KFE98_10750	COG4447	cellulose binding
KFE98_10760	COG0463	Glycosyl transferase, family 2
KFE98_10770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KFE98_10780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFE98_10815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KFE98_10825	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KFE98_10880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_10895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFE98_10905	COG0047	phosphoribosylformylglycinamidine synthase activity
KFE98_10905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFE98_10925	COG1228	amidohydrolase
KFE98_10930	COG1022	Amp-dependent synthetase and ligase
KFE98_10950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFE98_10970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KFE98_10985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFE98_11005	COG1595	DNA-templated transcription, initiation
KFE98_11015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFE98_11020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFE98_11040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KFE98_11065	COG1115	amino acid carrier protein
KFE98_11075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KFE98_11080	COG1960	acyl-CoA dehydrogenase activity
KFE98_11085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KFE98_11090	COG4974	Belongs to the 'phage' integrase family
KFE98_11140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFE98_11145	COG0081	regulation of translation
KFE98_11150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KFE98_11155	COG0222	ribosome binding
KFE98_11160	COG0085	RNA polymerase activity
KFE98_11165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFE98_11190	COG4591	ABC-type transport system involved in lipoprotein release permease component
KFE98_11195	COG3876	Protein conserved in bacteria
KFE98_11210	COG0022	dehydrogenase e1 component
KFE98_11255	COG2274	protein secretion by the type I secretion system
KFE98_11265	COG1295	ribonuclease BN
KFE98_11280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFE98_11300	COG0443	Heat shock 70 kDa protein
KFE98_11310	COG0577	efflux transmembrane transporter activity
KFE98_11335	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFE98_11340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFE98_11360	COG0438	transferase activity, transferring glycosyl groups
KFE98_11370	COG1086	Polysaccharide biosynthesis protein
KFE98_11390	COG2089	acid synthase
KFE98_11395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFE98_11400	COG0107	imidazoleglycerol-phosphate synthase activity
KFE98_11440	COG0463	Glycosyl transferase, family 2
KFE98_11440	COG1216	Glycosyl transferase, family 2
KFE98_11450	COG0438	transferase activity, transferring glycosyl groups
KFE98_11460	COG0673	inositol 2-dehydrogenase activity
KFE98_11480	COG0745	RESPONSE REGULATOR receiver
KFE98_11500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KFE98_11510	COG1575	Belongs to the MenA family. Type 1 subfamily
KFE98_11525	COG0564	pseudouridine synthase activity
KFE98_11540	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFE98_11545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFE98_11555	COG2153	protein acetylation
KFE98_11560	COG1074	ATP-dependent DNA helicase activity
KFE98_11580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KFE98_11600	COG3220	belongs to the UPF0276 family
KFE98_11625	COG1611	Belongs to the LOG family
KFE98_11640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFE98_11655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFE98_11690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KFE98_11695	COG1663	tetraacyldisaccharide 4'-kinase activity
KFE98_11705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFE98_11710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE98_11725	COG0308	aminopeptidase N
KFE98_11735	COG0359	binds to the 23S rRNA
KFE98_11740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFE98_11745	COG0360	Binds together with S18 to 16S ribosomal RNA
KFE98_11755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFE98_11765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE98_11770	COG3591	Belongs to the peptidase S1B family
KFE98_11790	COG0484	heat shock protein binding
KFE98_11820	COG3956	TIGRFAM MazG family protein
KFE98_11840	COG1160	GTP binding
KFE98_11885	COG0463	Glycosyl transferase, family 2
KFE98_11890	COG1058	Belongs to the CinA family
KFE98_11890	COG1546	Belongs to the CinA family
KFE98_11895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFE98_11910	COG0116	Belongs to the methyltransferase superfamily
KFE98_11925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KFE98_11935	COG0215	cysteine-tRNA ligase activity
KFE98_11940	COG0302	gtp cyclohydrolase
KFE98_11975	COG1269	ATP hydrolysis coupled proton transport
KFE98_11985	COG1394	ATPase activity, coupled to movement of substances
KFE98_11990	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
KFE98_11995	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KFE98_12015	COG0688	phosphatidylethanolamine metabolic process
KFE98_12020	COG4589	Belongs to the CDS family
KFE98_12030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFE98_12035	COG0799	negative regulation of ribosome biogenesis
KFE98_12050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFE98_12195	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFE98_12200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KFE98_12210	COG0673	inositol 2-dehydrogenase activity
KFE98_12230	COG0483	inositol monophosphate 1-phosphatase activity
KFE98_12235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFE98_12245	COG4974	Belongs to the 'phage' integrase family
KFE98_12255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KFE98_12275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFE98_12285	COG0716	FMN binding
KFE98_12290	COG0335	large ribosomal subunit rRNA binding
KFE98_12295	COG0336	Belongs to the RNA methyltransferase TrmD family
KFE98_12310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFE98_12345	COG2824	Alkylphosphonate utilization operon protein PhnA
KFE98_12380	COG0523	cobalamin synthesis protein
KFE98_12410	COG1695	Transcriptional regulator
KFE98_12440	COG2326	polyphosphate kinase activity
KFE98_12445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KFE98_12450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFE98_12455	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KFE98_12465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KFE98_12465	COG0519	Catalyzes the synthesis of GMP from XMP
KFE98_12470	COG0791	NLP P60 protein
KFE98_12470	COG1388	LysM domain
KFE98_12475	COG0408	coproporphyrinogen oxidase activity
KFE98_12485	COG1674	ftsk spoiiie
KFE98_12495	COG0018	arginyl-trna synthetase
KFE98_12500	COG2201	protein-glutamate methylesterase activity
KFE98_12505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFE98_12510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFE98_12535	COG3119	arylsulfatase activity
KFE98_12545	COG0842	Transport permease protein
KFE98_12545	COG1716	ATPase activity
KFE98_12545	COG1131	(ABC) transporter
KFE98_12550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KFE98_12560	COG3279	Response regulator of the LytR AlgR family
KFE98_12565	COG3275	phosphorelay sensor kinase activity
KFE98_12580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFE98_12600	COG0681	Belongs to the peptidase S26 family
KFE98_12605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFE98_12615	COG1475	DNA binding
KFE98_12620	COG1192	Involved in chromosome partitioning
KFE98_12625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KFE98_12685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KFE98_12705	COG0813	purine-nucleoside phosphorylase activity
KFE98_12715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KFE98_12720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFE98_12725	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KFE98_12730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFE98_12735	COG0228	four-way junction DNA binding
KFE98_12740	COG3011	Protein conserved in bacteria
KFE98_12750	COG1132	(ABC) transporter
KFE98_12755	COG0101	tRNA pseudouridine synthase activity
KFE98_12780	COG0826	peptidase U32
KFE98_12790	COG2885	chlorophyll binding
KFE98_12790	COG3047	cAMP biosynthetic process
KFE98_12810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFE98_12815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFE98_12840	COG0386	Belongs to the glutathione peroxidase family
KFE98_12845	COG0339	signal peptide processing
KFE98_12870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFE98_12935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KFE98_12965	COG1418	mRNA catabolic process
KFE98_12970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFE98_12980	COG0277	FAD linked oxidase domain protein
KFE98_13005	COG0745	RESPONSE REGULATOR receiver
KFE98_13035	COG3279	Response regulator of the LytR AlgR family
KFE98_13050	COG1703	isobutyryl-CoA mutase activity
KFE98_13050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFE98_13050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFE98_13055	COG2814	Major facilitator Superfamily
KFE98_13070	COG3275	phosphorelay sensor kinase activity
KFE98_13085	COG1136	(ABC) transporter
KFE98_13090	COG0577	efflux transmembrane transporter activity
KFE98_13090	COG1136	(ABC) transporter
KFE98_13100	COG0577	efflux transmembrane transporter activity
KFE98_13100	COG1136	(ABC) transporter
KFE98_13105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE98_13125	COG0514	ATP-dependent DNA helicase (RecQ)
KFE98_13140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFE98_13175	COG2226	methyltransferase
KFE98_13180	COG2197	response regulator
KFE98_13300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KFE98_13380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFE98_13385	COG0525	valine-tRNA ligase activity
KFE98_13400	COG1309	transcriptional regulator
KFE98_13405	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_13425	COG0436	Aminotransferase
KFE98_13435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFE98_13445	COG0552	protein localization to endoplasmic reticulum
KFE98_13450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KFE98_13470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFE98_13475	COG1301	dicarboxylic acid transport
KFE98_13490	COG2885	chlorophyll binding
KFE98_13500	COG3958	Transketolase
KFE98_13505	COG2304	oxidoreductase activity
KFE98_13540	COG0012	GTP binding
KFE98_13585	COG0156	8-amino-7-oxononanoate synthase activity
KFE98_13615	COG0497	DNA recombination
KFE98_13620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KFE98_13635	COG0045	succinate-CoA ligase (ADP-forming) activity
KFE98_13640	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFE98_13645	COG1805	sodium ion transport
KFE98_13650	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFE98_13655	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFE98_13660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KFE98_13670	COG1477	protein flavinylation
KFE98_13685	COG0268	Binds directly to 16S ribosomal RNA
KFE98_13690	COG2003	Belongs to the UPF0758 family
KFE98_13710	COG1862	Preprotein translocase
KFE98_13725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KFE98_13725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFE98_13735	COG0545	Peptidyl-prolyl cis-trans isomerase
KFE98_13740	COG0545	Peptidyl-prolyl cis-trans isomerase
KFE98_13750	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KFE98_13765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KFE98_13775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFE98_13780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KFE98_13785	COG0156	8-amino-7-oxononanoate synthase activity
KFE98_13795	COG0326	Molecular chaperone. Has ATPase activity
KFE98_13830	COG0494	nUDIX hydrolase
KFE98_13835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFE98_13835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KFE98_13875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFE98_13895	COG0259	pyridoxamine-phosphate oxidase activity
KFE98_13915	COG3279	Response regulator of the LytR AlgR family
KFE98_13950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFE98_13955	COG2205	protein histidine kinase activity
KFE98_13955	COG3292	Two component regulator propeller
KFE98_13955	COG0745	RESPONSE REGULATOR receiver
KFE98_13960	COG0534	Mate efflux family protein
KFE98_13975	COG2885	chlorophyll binding
KFE98_13975	COG3047	cAMP biosynthetic process
KFE98_14060	COG1215	transferase activity, transferring glycosyl groups
KFE98_14090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFE98_14095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KFE98_14110	COG0592	DNA-directed DNA polymerase activity
KFE98_14130	COG0527	aspartate kinase activity
KFE98_14135	COG0019	diaminopimelate decarboxylase activity
KFE98_14140	COG2226	methyltransferase
KFE98_14150	COG1858	cytochrome C peroxidase
KFE98_14185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFE98_14225	COG2217	Heavy metal translocating P-type atpase
KFE98_14260	COG1858	cytochrome C peroxidase
KFE98_14265	COG1858	cytochrome C peroxidase
KFE98_14270	COG0720	synthase
KFE98_14275	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KFE98_14285	COG1233	COG1233 Phytoene dehydrogenase and related
KFE98_14290	COG1595	DNA-templated transcription, initiation
KFE98_14355	COG4717	serine-type aminopeptidase activity
KFE98_14360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFE98_14365	COG0583	DNA-binding transcription factor activity
KFE98_14375	COG0463	Glycosyl transferase, family 2
KFE98_14385	COG2154	pterin-4-alpha-carbinolamine dehydratase
KFE98_14445	COG0706	membrane insertase activity
KFE98_14450	COG0706	membrane insertase activity
KFE98_14455	COG0504	CTP synthase activity
KFE98_14460	COG3279	Response regulator of the LytR AlgR family
KFE98_14465	COG2972	Histidine kinase
KFE98_14505	COG1196	nuclear chromosome segregation
KFE98_14505	COG0741	lytic transglycosylase activity
KFE98_14505	COG0739	heme binding
KFE98_14520	COG1858	cytochrome C peroxidase
KFE98_14575	COG2353	YceI-like domain
KFE98_14610	COG0456	acetyltransferase
KFE98_14660	COG3384	dioxygenase
KFE98_14670	COG1733	regulation of RNA biosynthetic process
KFE98_14675	COG3361	conserved protein (COG2071)
KFE98_14730	COG2207	Transcriptional regulator
KFE98_14745	COG0702	epimerase
KFE98_14785	COG2153	protein acetylation
KFE98_14815	COG0492	ferredoxin-NADP+ reductase activity
KFE98_14840	COG0563	adenylate kinase activity
KFE98_14865	COG3604	Transcriptional regulator
KFE98_14905	COG1132	(ABC) transporter
KFE98_14915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFE98_14920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KFE98_14935	COG1733	regulation of RNA biosynthetic process
KFE98_14975	COG0456	acetyltransferase
KFE98_15025	COG0737	Belongs to the 5'-nucleotidase family
KFE98_15105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KFE98_15110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KFE98_15120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KFE98_15125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFE98_15145	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFE98_15160	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFE98_15180	COG0589	response to stress
KFE98_15195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KFE98_15260	COG0123	including yeast histone deacetylase and acetoin utilization protein
KFE98_15285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFE98_15365	COG0602	queuosine metabolic process
KFE98_15395	COG1228	amidohydrolase
KFE98_15430	COG1234	tRNA 3'-trailer cleavage
KFE98_15440	COG1366	Belongs to the anti-sigma-factor antagonist family
KFE98_15445	COG0540	Belongs to the ATCase OTCase family
KFE98_15450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KFE98_15470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KFE98_15475	COG3396	Phenylacetate-CoA oxygenase
KFE98_15480	COG3460	Phenylacetate-CoA oxygenase
KFE98_15485	COG3396	Phenylacetate-CoA oxygenase
KFE98_15490	COG2151	metal-sulfur cluster biosynthetic enzyme
KFE98_15500	COG1024	Enoyl-CoA hydratase
KFE98_15505	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFE98_15545	COG0183	Belongs to the thiolase family
KFE98_15570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFE98_15615	COG2920	part of a sulfur-relay system
KFE98_15620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFE98_15645	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KFE98_15650	COG4977	sequence-specific DNA binding
KFE98_15650	COG1917	Cupin 2, conserved barrel domain protein
KFE98_15655	COG0300	oxidoreductase activity
KFE98_15660	COG4221	oxidoreductase activity
KFE98_15680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFE98_15680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFE98_15685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFE98_15695	COG1538	Outer membrane efflux protein
KFE98_15700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFE98_15710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE98_15735	COG0784	Response regulator, receiver
KFE98_15745	COG0668	transmembrane transport
KFE98_15755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFE98_15760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KFE98_15770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFE98_15775	COG2385	sporulation resulting in formation of a cellular spore
KFE98_15775	COG2247	cell wall binding repeat
KFE98_15780	COG2333	competence protein COMEC
KFE98_15780	COG0658	competence protein
KFE98_15785	COG0517	IMP dehydrogenase activity
KFE98_15785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KFE98_15785	COG0617	tRNA 3'-terminal CCA addition
KFE98_15790	COG0009	L-threonylcarbamoyladenylate synthase
KFE98_15805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KFE98_15810	COG0242	peptide deformylase activity
KFE98_15825	COG1254	Belongs to the acylphosphatase family
KFE98_15840	COG2207	Transcriptional regulator
KFE98_15875	COG0604	alcohol dehydrogenase
KFE98_15945	COG0101	tRNA pseudouridine synthase activity
KFE98_15955	COG1858	cytochrome C peroxidase
KFE98_16015	COG4585	Histidine kinase
KFE98_16020	COG2197	response regulator
KFE98_16040	COG0488	(ABC) transporter
KFE98_16190	COG1215	transferase activity, transferring glycosyl groups
KFE98_16200	COG3118	belongs to the thioredoxin family
KFE98_16290	COG2095	MarC family integral membrane protein
KFE98_16320	COG0300	oxidoreductase activity
KFE98_16360	COG0629	single-stranded DNA binding
KFE98_16415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFE98_16450	COG3781	membrane
KFE98_16455	COG0454	-acetyltransferase
KFE98_16465	COG0640	Transcriptional regulator
KFE98_16470	COG5658	integral membrane protein
KFE98_16485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFE98_16495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFE98_16555	COG3842	ATPase activity
KFE98_16575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFE98_16580	COG0314	molybdopterin synthase activity
KFE98_16585	COG0315	cyclic pyranopterin monophosphate synthase activity
KFE98_16585	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFE98_16595	COG0656	L-ascorbic acid biosynthetic process
KFE98_16600	COG2949	membrane
KFE98_16625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFE98_16630	COG3781	membrane
KFE98_16635	COG0784	Response regulator, receiver
KFE98_16635	COG2205	protein histidine kinase activity
KFE98_16660	COG1408	metallophosphoesterase
KFE98_16665	COG3292	Two component regulator propeller
KFE98_16665	COG0745	RESPONSE REGULATOR receiver
KFE98_16665	COG2205	protein histidine kinase activity
KFE98_16675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFE98_16695	COG1090	epimerase
KFE98_16730	COG3781	membrane
KFE98_16735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFE98_16750	COG0659	secondary active sulfate transmembrane transporter activity
KFE98_16755	COG0514	ATP-dependent DNA helicase (RecQ)
KFE98_16805	COG1858	cytochrome C peroxidase
KFE98_16830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KFE98_16845	COG2972	Histidine kinase
KFE98_16850	COG3279	Response regulator of the LytR AlgR family
KFE98_17045	COG3279	Response regulator of the LytR AlgR family
KFE98_17050	COG3275	phosphorelay sensor kinase activity
KFE98_17075	COG2258	MOSC domain
KFE98_17165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KFE98_17170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KFE98_17180	COG1205	dead DEAH box helicase
KFE98_17180	COG1111	helicase
KFE98_17205	COG2197	response regulator
KFE98_17210	COG4585	Histidine kinase
KFE98_17250	COG2972	Histidine kinase
KFE98_17260	COG2197	response regulator
KFE98_17270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KFE98_17275	COG0583	DNA-binding transcription factor activity
KFE98_17280	COG2207	Transcriptional regulator
KFE98_17330	COG3291	Pkd domain containing protein
KFE98_17340	COG1846	Transcriptional regulator
KFE98_17345	COG0778	Nitroreductase
KFE98_17400	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KFE98_17410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KFE98_17420	COG0402	S-adenosylhomocysteine deaminase activity
KFE98_17475	COG2353	YceI-like domain
KFE98_17490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFE98_17500	COG0527	aspartate kinase activity
KFE98_17500	COG0460	homoserine dehydrogenase
KFE98_17505	COG2312	Erythromycin esterase
KFE98_17510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KFE98_17535	COG2205	protein histidine kinase activity
KFE98_17555	COG2003	Belongs to the UPF0758 family
KFE98_17560	COG0702	epimerase
KFE98_17600	COG0823	Involved in the tonB-independent uptake of proteins
KFE98_17615	COG3279	Response regulator of the LytR AlgR family
KFE98_17620	COG3920	Histidine kinase
KFE98_17660	COG2197	response regulator
KFE98_17680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KFE98_17700	COG0210	DNA helicase
KFE98_17725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KFE98_17750	COG2003	Belongs to the UPF0758 family
KFE98_17830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFE98_17835	COG0542	response to heat
KFE98_17870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KFE98_17875	COG0105	UTP biosynthetic process
KFE98_17885	COG0534	Mate efflux family protein
KFE98_17905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFE98_17910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFE98_17910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFE98_17915	COG2814	Major facilitator Superfamily
KFE98_17925	COG3258	Cytochrome c
KFE98_17940	COG2391	methyltransferase activity
KFE98_17955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFE98_17960	COG2197	response regulator
KFE98_17970	COG4585	Histidine kinase
KFE98_18020	COG2365	Tyrosine phosphatase family
KFE98_18060	COG2169	Transcriptional regulator
KFE98_18060	COG1917	Cupin 2, conserved barrel domain protein
KFE98_18070	COG0659	secondary active sulfate transmembrane transporter activity
KFE98_18120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFE98_18125	COG4221	oxidoreductase activity
KFE98_18155	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KFE98_18160	COG3290	protein histidine kinase activity
KFE98_18165	COG0456	acetyltransferase
KFE98_18170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFE98_18225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KFE98_18225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KFE98_18235	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KFE98_18280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFE98_18305	COG5002	protein histidine kinase activity
KFE98_18310	COG0745	RESPONSE REGULATOR receiver
KFE98_18325	COG3279	Response regulator of the LytR AlgR family
KFE98_18330	COG3275	phosphorelay sensor kinase activity
KFE98_18360	COG4771	TonB-dependent receptor
KFE98_18385	COG2329	Antibiotic biosynthesis monooxygenase
KFE98_18390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFE98_18410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KFE98_18415	COG1690	Belongs to the RtcB family
KFE98_18445	COG0783	Belongs to the Dps family
KFE98_18490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFE98_18495	COG0513	Belongs to the DEAD box helicase family
KFE98_18550	COG0534	Mate efflux family protein
KFE98_18565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KFE98_18580	COG1073	alpha beta
KFE98_18610	COG1061	Type III restriction enzyme res subunit
KFE98_18645	COG0217	transcriptional regulatory protein
KFE98_18675	COG1191	sigma factor activity
KFE98_18690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KFE98_18715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFE98_18725	COG1201	RNA secondary structure unwinding
KFE98_18735	COG3275	phosphorelay sensor kinase activity
KFE98_18765	COG0588	phosphoglycerate mutase activity
KFE98_18785	COG0175	sulfate reduction
KFE98_18790	COG1959	2 iron, 2 sulfur cluster binding
KFE98_18795	COG0167	dihydroorotate dehydrogenase activity
KFE98_18810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFE98_18810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFE98_18820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFE98_18830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFE98_18865	COG2195	Cleaves the N-terminal amino acid of tripeptides
KFE98_18875	COG1678	Uncharacterized ACR, COG1678
KFE98_18880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFE98_18895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFE98_18900	COG0668	transmembrane transport
KFE98_18905	COG1607	acyl-coa hydrolase
KFE98_18940	COG2608	mercury ion transmembrane transporter activity
KFE98_18960	COG1309	transcriptional regulator
KFE98_18975	COG3275	phosphorelay sensor kinase activity
KFE98_18980	COG3279	Response regulator of the LytR AlgR family
KFE98_18990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFE98_19005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KFE98_19005	COG0321	lipoyl(octanoyl) transferase activity
KFE98_19020	COG1696	Membrane protein involved in D-alanine export
KFE98_19030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFE98_19035	COG4106	trans-aconitate 2-methyltransferase activity
KFE98_19045	COG1809	phosphosulfolactate synthase activity
KFE98_19060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KFE98_19065	COG0308	aminopeptidase N
KFE98_19070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFE98_19080	COG2890	protein-(glutamine-N5) methyltransferase activity
KFE98_19100	COG1480	7TM receptor with intracellular HD hydrolase
KFE98_19155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KFE98_19165	COG4968	Prepilin-type N-terminal cleavage methylation domain
KFE98_19180	COG0482	sulfurtransferase activity
KFE98_19215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFE98_19225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KFE98_19235	COG0714	Associated with various cellular activities
KFE98_19255	COG2304	oxidoreductase activity
KFE98_19275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFE98_19280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFE98_19290	COG1595	DNA-templated transcription, initiation
KFE98_19295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KFE98_19340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFE98_19345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFE98_19420	COG0583	DNA-binding transcription factor activity
KFE98_19430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KFE98_19440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFE98_19445	COG0131	Imidazoleglycerol-phosphate dehydratase
KFE98_19455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KFE98_19460	COG0107	imidazoleglycerol-phosphate synthase activity
KFE98_19465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFE98_19465	COG0140	phosphoribosyl-ATP diphosphatase activity
KFE98_19480	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
KFE98_19505	COG1051	belongs to the nudix hydrolase family
KFE98_19505	COG1056	cytidyltransferase-related domain
KFE98_19525	COG1027	Aspartate ammonia-lyase
KFE98_19685	COG1459	type II secretion system
KFE98_19710	COG1785	Belongs to the alkaline phosphatase family
KFE98_19765	COG2197	response regulator
KFE98_19800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KFE98_19810	COG2264	protein methyltransferase activity
KFE98_19815	COG0149	triose-phosphate isomerase activity
KFE98_19825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFE98_19840	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_19840	COG2030	dehydratase
KFE98_19850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KFE98_19855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFE98_19880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KFE98_19930	COG0415	Belongs to the DNA photolyase family
KFE98_19935	COG2223	nitrite transmembrane transporter activity
KFE98_19955	COG1573	uracil-dna glycosylase
KFE98_19970	COG2318	DinB family
KFE98_19985	COG4251	negative regulation of phosphorylation
KFE98_20000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KFE98_20110	COG0028	Belongs to the TPP enzyme family
KFE98_20120	COG0463	Glycosyl transferase, family 2
KFE98_20180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KFE98_20185	COG0612	Peptidase, M16
KFE98_20215	COG0542	response to heat
KFE98_20255	COG1950	PFAM Membrane protein of
KFE98_20280	COG1073	alpha beta
KFE98_20325	COG3275	phosphorelay sensor kinase activity
KFE98_20360	COG4771	TonB-dependent receptor
KFE98_20405	COG0183	Belongs to the thiolase family
KFE98_20410	COG1187	pseudouridine synthase activity
KFE98_20505	COG5002	protein histidine kinase activity
KFE98_20530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KFE98_20625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFE98_20630	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KFE98_20635	COG4771	TonB-dependent receptor
KFE98_20645	COG0793	Belongs to the peptidase S41A family
KFE98_20660	COG0010	Belongs to the arginase family
KFE98_20695	COG0596	Alpha beta hydrolase
KFE98_20700	COG1858	cytochrome C peroxidase
KFE98_20715	COG4335	DNA alkylation repair
KFE98_20725	COG1404	Belongs to the peptidase S8 family
KFE98_20730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KFE98_20770	COG1819	glycosyl
KFE98_20790	COG3275	phosphorelay sensor kinase activity
KFE98_20795	COG3279	Response regulator of the LytR AlgR family
KFE98_20815	COG3119	arylsulfatase activity
KFE98_20830	COG2814	Major facilitator Superfamily
KFE98_20835	COG2813	Specifically methylates the guanine in position
KFE98_20855	COG4181	ATPase activity
KFE98_20860	COG1136	(ABC) transporter
KFE98_20860	COG0577	efflux transmembrane transporter activity
KFE98_20865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFE98_20930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFE98_20935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFE98_20970	COG0492	ferredoxin-NADP+ reductase activity
KFE98_20980	COG0716	FMN binding
KFE98_20985	COG1073	alpha beta
KFE98_21000	COG2207	Transcriptional regulator
KFE98_21005	COG3321	synthase
KFE98_21005	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_21005	COG0604	alcohol dehydrogenase
KFE98_21085	COG4221	oxidoreductase activity
KFE98_21090	COG4221	oxidoreductase activity
KFE98_21105	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_21140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KFE98_21160	COG0708	Exodeoxyribonuclease III
KFE98_21170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KFE98_21215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KFE98_21220	COG3291	Pkd domain containing protein
KFE98_21230	COG2897	thiosulfate sulfurtransferase activity
KFE98_21260	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KFE98_21285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KFE98_21310	COG0429	hydrolase of the alpha beta-hydrolase fold
KFE98_21320	COG1704	LemA family
KFE98_21325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KFE98_21335	COG0784	Response regulator, receiver
KFE98_21335	COG2205	protein histidine kinase activity
KFE98_21350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFE98_21355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFE98_21360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KFE98_21365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFE98_21405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFE98_21480	COG2201	protein-glutamate methylesterase activity
KFE98_21490	COG1028	Short-chain dehydrogenase reductase Sdr
KFE98_21495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFE98_21515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFE98_21530	COG4251	negative regulation of phosphorylation
KFE98_21545	COG3292	Two component regulator propeller
KFE98_21545	COG2205	protein histidine kinase activity
KFE98_21545	COG0745	RESPONSE REGULATOR receiver
KFE98_21570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KFE98_21580	COG0254	rRNA binding
KFE98_21610	COG0556	nucleotide-excision repair
KFE98_21615	COG1858	cytochrome C peroxidase
KFE98_21635	COG1011	Hydrolase
KFE98_21645	COG1012	belongs to the aldehyde dehydrogenase family
KFE98_21665	COG0010	Belongs to the arginase family
KFE98_21670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KFE98_21675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFE98_21675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFE98_21680	COG0784	Response regulator, receiver
KFE98_21680	COG2205	protein histidine kinase activity
KFE98_21685	COG0697	spore germination
KFE98_21690	COG1739	Uncharacterized protein family UPF0029