locus-tag	class	description
KFF05_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KFF05_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KFF05_00030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KFF05_00045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_00060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KFF05_00065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KFF05_00100	COG1492	cobalamin metabolic process
KFF05_00115	COG2154	pterin-4-alpha-carbinolamine dehydratase
KFF05_00125	COG0668	transmembrane transport
KFF05_00155	COG1872	DUF167
KFF05_00160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KFF05_00165	COG1278	Cold shock
KFF05_00175	COG1280	lysine exporter protein (LysE YggA)
KFF05_00205	COG0678	peroxiredoxin activity
KFF05_00210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFF05_00215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFF05_00220	COG2130	NADP-dependent
KFF05_00230	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KFF05_00235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFF05_00275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KFF05_00280	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KFF05_00285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFF05_00325	COG1137	ATPase activity
KFF05_00330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KFF05_00335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KFF05_00340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFF05_00365	COG0747	negative chemotaxis
KFF05_00370	COG0601	transmembrane transport
KFF05_00375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFF05_00380	COG0444	Belongs to the ABC transporter superfamily
KFF05_00385	COG4608	Belongs to the ABC transporter superfamily
KFF05_00395	COG2202	Pas domain
KFF05_00395	COG2205	protein histidine kinase activity
KFF05_00400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFF05_00550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KFF05_00560	COG0539	negative regulation of cytoplasmic translation
KFF05_00565	COG0616	signal peptide processing
KFF05_00570	COG0776	regulation of translation
KFF05_00580	COG0284	orotidine-5'-phosphate decarboxylase activity
KFF05_00590	COG0133	tryptophan synthase activity
KFF05_00600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KFF05_00605	COG0285	dihydrofolate synthase activity
KFF05_00615	COG1230	cation diffusion facilitator family transporter
KFF05_00625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFF05_00635	COG1074	ATP-dependent DNA helicase activity
KFF05_00645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KFF05_00650	COG3178	'Phosphotransferase
KFF05_00655	COG0802	atpase or kinase
KFF05_00675	COG2205	protein histidine kinase activity
KFF05_00680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KFF05_00690	COG0596	Alpha beta hydrolase
KFF05_00700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFF05_00710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KFF05_00710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KFF05_00715	COG1660	Displays ATPase and GTPase activities
KFF05_00720	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KFF05_00725	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_00735	COG2205	protein histidine kinase activity
KFF05_00740	COG0745	RESPONSE REGULATOR receiver
KFF05_00760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KFF05_00780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KFF05_00800	COG0069	glutamate synthase activity
KFF05_00800	COG0067	glutamate synthase
KFF05_00800	COG0070	glutamate synthase
KFF05_00805	COG1968	undecaprenyl-diphosphatase activity
KFF05_00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_00815	COG4172	Belongs to the ABC transporter superfamily
KFF05_00820	COG4239	(ABC) transporter, permease
KFF05_00825	COG4174	ABC transporter (Permease)
KFF05_00830	COG4166	transmembrane transport
KFF05_00840	COG3474	cytochrome
KFF05_00860	COG2205	protein histidine kinase activity
KFF05_00860	COG2198	Histidine kinase
KFF05_00860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF05_00860	COG0784	Response regulator, receiver
KFF05_00875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KFF05_00885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KFF05_00890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KFF05_00905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KFF05_00910	COG0242	peptide deformylase activity
KFF05_00920	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KFF05_00925	COG2827	Endonuclease containing a URI domain
KFF05_00940	COG1278	Cold shock
KFF05_00945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KFF05_00950	COG1294	oxidase, subunit
KFF05_00955	COG1271	oxidase subunit
KFF05_00980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFF05_00985	COG2171	N-acyltransferase activity
KFF05_01000	COG0154	amidase activity
KFF05_01005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KFF05_01010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KFF05_01015	COG0706	membrane insertase activity
KFF05_01020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KFF05_01030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KFF05_01045	COG5000	phosphorelay sensor kinase activity
KFF05_01050	COG4106	trans-aconitate 2-methyltransferase activity
KFF05_01060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFF05_01080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFF05_01105	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KFF05_01120	COG3128	pkhd-type hydroxylase
KFF05_01130	COG2076	Multidrug Resistance protein
KFF05_01155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KFF05_01200	COG1566	PFAM secretion protein HlyD family protein
KFF05_01205	COG1846	Transcriptional regulator
KFF05_01210	COG2814	Major facilitator Superfamily
KFF05_01215	COG1012	belongs to the aldehyde dehydrogenase family
KFF05_01220	COG0415	Belongs to the DNA photolyase family
KFF05_01230	COG2264	protein methyltransferase activity
KFF05_01235	COG0210	DNA helicase
KFF05_01250	COG0745	RESPONSE REGULATOR receiver
KFF05_01260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KFF05_01265	COG0573	inorganic phosphate transmembrane transporter activity
KFF05_01270	COG0573	inorganic phosphate transmembrane transporter activity
KFF05_01275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KFF05_01280	COG0306	phosphate transporter
KFF05_01285	COG5002	protein histidine kinase activity
KFF05_01290	COG3706	GGDEF domain
KFF05_01300	COG0463	Glycosyl transferase, family 2
KFF05_01320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFF05_01345	COG3707	response regulator
KFF05_01350	COG1309	transcriptional regulator
KFF05_01370	COG1733	regulation of RNA biosynthetic process
KFF05_01375	COG3707	response regulator
KFF05_01380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFF05_01385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFF05_01390	COG1116	anion transmembrane transporter activity
KFF05_01390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFF05_01395	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KFF05_01405	COG0523	cobalamin synthesis protein
KFF05_01425	COG2202	Pas domain
KFF05_01425	COG2205	protein histidine kinase activity
KFF05_01430	COG2084	Dehydrogenase
KFF05_01440	COG1199	ATP-dependent helicase activity
KFF05_01440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFF05_01455	COG2226	methyltransferase
KFF05_01470	COG0488	(ABC) transporter
KFF05_01475	COG2176	DNA-directed DNA polymerase activity
KFF05_01475	COG5002	protein histidine kinase activity
KFF05_01515	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_01520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_01525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFF05_01535	COG1760	l-serine dehydratase
KFF05_01540	COG0583	DNA-binding transcription factor activity
KFF05_01545	COG2301	Belongs to the HpcH HpaI aldolase family
KFF05_01550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_01565	COG1671	Belongs to the UPF0178 family
KFF05_01580	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFF05_01585	COG2186	Transcriptional regulator
KFF05_01610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFF05_01615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_01630	COG1999	signal sequence binding
KFF05_01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFF05_01655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF05_01660	COG2188	Transcriptional regulator
KFF05_01675	COG1053	succinate dehydrogenase
KFF05_01685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KFF05_01685	COG0674	pyruvate-flavodoxin oxidoreductase activity
KFF05_01690	COG1013	pyruvate-flavodoxin oxidoreductase activity
KFF05_01730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFF05_01740	COG0583	DNA-binding transcription factor activity
KFF05_01750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KFF05_01765	COG0505	Belongs to the CarA family
KFF05_01770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KFF05_01775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFF05_01795	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KFF05_01810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KFF05_01825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_01830	COG1960	acyl-CoA dehydrogenase activity
KFF05_01835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFF05_01855	COG0517	IMP dehydrogenase activity
KFF05_01855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KFF05_01860	COG0625	glutathione transferase activity
KFF05_01870	COG2175	clavaminate synthase activity
KFF05_01890	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_01905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_01915	COG2198	Histidine kinase
KFF05_01915	COG0784	Response regulator, receiver
KFF05_01915	COG2205	protein histidine kinase activity
KFF05_01935	COG0840	transmembrane signaling receptor activity
KFF05_01945	COG0840	transmembrane signaling receptor activity
KFF05_01965	COG0492	ferredoxin-NADP+ reductase activity
KFF05_01985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KFF05_01990	COG1234	tRNA 3'-trailer cleavage
KFF05_01995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_02000	COG0798	PFAM Bile acid sodium symporter
KFF05_02125	COG5002	protein histidine kinase activity
KFF05_02125	COG2205	protein histidine kinase activity
KFF05_02125	COG0784	Response regulator, receiver
KFF05_02135	COG1573	uracil-dna glycosylase
KFF05_02140	COG0741	lytic transglycosylase activity
KFF05_02145	COG0521	Mo-molybdopterin cofactor biosynthetic process
KFF05_02230	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFF05_02260	COG0604	alcohol dehydrogenase
KFF05_02265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFF05_02265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFF05_02270	COG1309	transcriptional regulator
KFF05_02285	COG0006	proline dipeptidase activity
KFF05_02295	COG0450	alkyl hydroperoxide reductase
KFF05_02305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF05_02310	COG0165	Argininosuccinate lyase
KFF05_02320	COG0019	diaminopimelate decarboxylase activity
KFF05_02335	COG2884	Cell division ATP-binding protein ftsE
KFF05_02375	COG1678	Uncharacterized ACR, COG1678
KFF05_02400	COG2847	Copper chaperone PCu(A)C
KFF05_02405	COG0287	Prephenate dehydrogenase
KFF05_02440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KFF05_02455	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_02460	COG0183	Belongs to the thiolase family
KFF05_02470	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
KFF05_02475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KFF05_02475	COG0515	serine threonine protein kinase
KFF05_02485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KFF05_02490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KFF05_02495	COG0602	queuosine metabolic process
KFF05_02500	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KFF05_02520	COG0720	synthase
KFF05_02525	COG0720	synthase
KFF05_02540	COG0343	queuine tRNA-ribosyltransferase activity
KFF05_02545	COG0840	transmembrane signaling receptor activity
KFF05_02555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KFF05_02570	COG0673	inositol 2-dehydrogenase activity
KFF05_02580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_02590	COG0601	transmembrane transport
KFF05_02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFF05_02600	COG0444	Belongs to the ABC transporter superfamily
KFF05_02605	COG4608	Belongs to the ABC transporter superfamily
KFF05_02620	COG0154	amidase activity
KFF05_02640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFF05_02645	COG0235	Class ii aldolase
KFF05_02650	COG0367	asparagine synthase
KFF05_02655	COG0189	ligase activity
KFF05_02655	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFF05_02655	COG2918	glutathione biosynthetic process
KFF05_02670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KFF05_02670	COG1648	precorrin-2 dehydrogenase activity
KFF05_02680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF05_02695	COG1404	Belongs to the peptidase S8 family
KFF05_02705	COG1414	Transcriptional regulator
KFF05_02715	COG1012	belongs to the aldehyde dehydrogenase family
KFF05_02725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KFF05_02745	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KFF05_02750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFF05_02770	COG2193	ferroxidase activity
KFF05_02775	COG1858	cytochrome C peroxidase
KFF05_02780	COG0733	neurotransmitter:sodium symporter activity
KFF05_02790	COG0861	Integral membrane protein TerC family
KFF05_02810	COG2084	Dehydrogenase
KFF05_02850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KFF05_02890	COG0028	Belongs to the TPP enzyme family
KFF05_02895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFF05_02900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFF05_02915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFF05_02920	COG1490	D-aminoacyl-tRNA deacylase activity
KFF05_02965	COG2850	peptidyl-arginine hydroxylation
KFF05_02980	COG4948	Mandelate Racemase Muconate Lactonizing
KFF05_03030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFF05_03040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KFF05_03050	COG1802	Transcriptional regulator
KFF05_03055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFF05_03060	COG1032	radical SAM domain protein
KFF05_03075	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KFF05_03080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_03085	COG0625	glutathione transferase activity
KFF05_03090	COG0697	spore germination
KFF05_03125	COG2192	nodulation
KFF05_03130	COG1053	succinate dehydrogenase
KFF05_03180	COG1063	alcohol dehydrogenase
KFF05_03190	COG0069	glutamate synthase activity
KFF05_03195	COG2175	clavaminate synthase activity
KFF05_03200	COG0583	DNA-binding transcription factor activity
KFF05_03205	COG2175	clavaminate synthase activity
KFF05_03235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFF05_03240	COG2205	protein histidine kinase activity
KFF05_03240	COG2202	Pas domain
KFF05_03245	COG2832	Protein of unknown function (DUF454)
KFF05_03250	COG1127	ABC transporter
KFF05_03260	COG0784	Response regulator, receiver
KFF05_03260	COG2198	Histidine kinase
KFF05_03260	COG2205	protein histidine kinase activity
KFF05_03265	COG4948	Mandelate Racemase Muconate Lactonizing
KFF05_03285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFF05_03295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KFF05_03295	COG3608	succinylglutamate desuccinylase aspartoacylase
KFF05_03300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFF05_03315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_03325	COG2217	Heavy metal translocating P-type atpase
KFF05_03375	COG2239	Acts as a magnesium transporter
KFF05_03380	COG2239	Acts as a magnesium transporter
KFF05_03385	COG0668	transmembrane transport
KFF05_03390	COG0459	protein refolding
KFF05_03395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KFF05_03400	COG5425	PFAM Usg family protein
KFF05_03405	COG1297	OPT oligopeptide transporter protein
KFF05_03410	COG0745	RESPONSE REGULATOR receiver
KFF05_03440	COG1126	abc transporter atp-binding protein
KFF05_03475	COG2205	protein histidine kinase activity
KFF05_03475	COG2202	Pas domain
KFF05_03480	COG2205	protein histidine kinase activity
KFF05_03490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFF05_03495	COG1960	acyl-CoA dehydrogenase activity
KFF05_03500	COG0251	oxidation-reduction process
KFF05_03520	COG2205	protein histidine kinase activity
KFF05_03545	COG3474	cytochrome
KFF05_03570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KFF05_03575	COG0500	methyltransferase
KFF05_03580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KFF05_03585	COG0028	Belongs to the TPP enzyme family
KFF05_03585	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
KFF05_03600	COG0559	Belongs to the binding-protein-dependent transport system permease family
KFF05_03620	COG0829	nickel cation binding
KFF05_03625	COG0831	urea catabolic process
KFF05_03630	COG0832	Belongs to the urease beta subunit family
KFF05_03635	COG0804	urea catabolic process
KFF05_03640	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KFF05_03645	COG0830	nickel cation binding
KFF05_03650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KFF05_03670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF05_03690	COG1595	DNA-templated transcription, initiation
KFF05_03705	COG0436	Aminotransferase
KFF05_03715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFF05_03715	COG3153	acetyltransferase
KFF05_03740	COG0514	ATP-dependent DNA helicase (RecQ)
KFF05_03750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFF05_03770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFF05_03805	COG2132	Multicopper oxidase
KFF05_03825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF05_03830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF05_03840	COG1999	signal sequence binding
KFF05_03855	COG0789	Transcriptional regulator
KFF05_03965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KFF05_03970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KFF05_03975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KFF05_03985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KFF05_03990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KFF05_03995	COG0799	negative regulation of ribosome biogenesis
KFF05_04005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KFF05_04015	COG0793	Belongs to the peptidase S41A family
KFF05_04025	COG1051	belongs to the nudix hydrolase family
KFF05_04035	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_04040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KFF05_04050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KFF05_04055	COG1763	Mo-molybdopterin cofactor biosynthetic process
KFF05_04065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KFF05_04075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KFF05_04095	COG1846	Transcriptional regulator
KFF05_04100	COG0745	RESPONSE REGULATOR receiver
KFF05_04120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFF05_04135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KFF05_04165	COG1496	oxidoreductase activity
KFF05_04175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KFF05_04180	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_04200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KFF05_04205	COG0193	aminoacyl-tRNA hydrolase activity
KFF05_04210	COG0012	GTP binding
KFF05_04215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFF05_04220	COG0412	Dienelactone hydrolase
KFF05_04225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KFF05_04245	COG0625	glutathione transferase activity
KFF05_04250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_04280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KFF05_04285	COG0408	coproporphyrinogen oxidase activity
KFF05_04300	COG4786	Flagellar basal body rod
KFF05_04305	COG0604	alcohol dehydrogenase
KFF05_04315	COG1741	Belongs to the pirin family
KFF05_04320	COG0435	Glutathione S-transferase
KFF05_04325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KFF05_04340	COG2175	clavaminate synthase activity
KFF05_04360	COG0714	Associated with various cellular activities
KFF05_04370	COG0494	nUDIX hydrolase
KFF05_04380	COG0617	tRNA 3'-terminal CCA addition
KFF05_04420	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KFF05_04435	COG0384	phenazine biosynthesis protein PhzF
KFF05_04440	COG0840	transmembrane signaling receptor activity
KFF05_04455	COG0509	glycine decarboxylation via glycine cleavage system
KFF05_04460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KFF05_04475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KFF05_04480	COG0328	RNA-DNA hybrid ribonuclease activity
KFF05_04490	COG0583	DNA-binding transcription factor activity
KFF05_04515	COG0678	peroxiredoxin activity
KFF05_04520	COG4232	protein-disulfide reductase activity
KFF05_04525	COG1678	Uncharacterized ACR, COG1678
KFF05_04540	COG0612	Peptidase, M16
KFF05_04550	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KFF05_04555	COG0109	protoheme IX farnesyltransferase activity
KFF05_04560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFF05_04565	COG2322	membrane
KFF05_04570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KFF05_04575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KFF05_04580	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KFF05_04615	COG3243	poly(R)-hydroxyalkanoic acid synthase
KFF05_04620	COG2199	diguanylate cyclase activity
KFF05_04620	COG2200	EAL domain
KFF05_04630	COG2770	Histidine kinase
KFF05_04630	COG2208	phosphoserine phosphatase activity
KFF05_04640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KFF05_04645	COG1127	ABC transporter
KFF05_04680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KFF05_04700	COG0346	lactoylglutathione lyase activity
KFF05_04710	COG2391	methyltransferase activity
KFF05_04725	COG0446	pyridine nucleotide-disulphide oxidoreductase
KFF05_04755	COG0737	Belongs to the 5'-nucleotidase family
KFF05_04760	COG0785	Cytochrome C biogenesis protein
KFF05_04775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFF05_04785	COG0640	Transcriptional regulator
KFF05_04800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KFF05_04810	COG5002	protein histidine kinase activity
KFF05_04815	COG2267	carboxylic ester hydrolase activity
KFF05_04830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KFF05_04840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFF05_04865	COG0583	DNA-binding transcription factor activity
KFF05_04880	COG1530	ribonuclease E activity
KFF05_04885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KFF05_04905	COG1414	Transcriptional regulator
KFF05_04910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_04930	COG2175	clavaminate synthase activity
KFF05_04935	COG0583	DNA-binding transcription factor activity
KFF05_04945	COG3119	arylsulfatase activity
KFF05_04950	COG1809	phosphosulfolactate synthase activity
KFF05_04965	COG2175	clavaminate synthase activity
KFF05_04970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFF05_04975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFF05_04980	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KFF05_04995	COG1053	succinate dehydrogenase
KFF05_05005	COG2307	Protein conserved in bacteria
KFF05_05005	COG2308	Evidence 4 Homologs of previously reported genes of
KFF05_05020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFF05_05025	COG1024	Enoyl-CoA hydratase
KFF05_05030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_05045	COG0583	DNA-binding transcription factor activity
KFF05_05055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KFF05_05070	COG1063	alcohol dehydrogenase
KFF05_05090	COG2188	Transcriptional regulator
KFF05_05120	COG2414	aldehyde ferredoxin oxidoreductase
KFF05_05125	COG5002	protein histidine kinase activity
KFF05_05125	COG2205	protein histidine kinase activity
KFF05_05125	COG0784	Response regulator, receiver
KFF05_05130	COG0281	malic enzyme
KFF05_05130	COG0280	phosphate acetyltransferase
KFF05_05140	COG0697	spore germination
KFF05_05145	COG0700	Nucleoside recognition
KFF05_05160	COG0028	Belongs to the TPP enzyme family
KFF05_05190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFF05_05215	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_05230	COG0045	succinate-CoA ligase (ADP-forming) activity
KFF05_05240	COG1024	Enoyl-CoA hydratase
KFF05_05245	COG1960	acyl-CoA dehydrogenase activity
KFF05_05280	COG0564	pseudouridine synthase activity
KFF05_05300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KFF05_05320	COG0784	Response regulator, receiver
KFF05_05330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KFF05_05335	COG0793	Belongs to the peptidase S41A family
KFF05_05340	COG0557	exoribonuclease II activity
KFF05_05345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KFF05_05350	COG0758	DNA mediated transformation
KFF05_05355	COG2814	Major facilitator Superfamily
KFF05_05370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KFF05_05375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KFF05_05380	COG0540	Belongs to the ATCase OTCase family
KFF05_05400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFF05_05405	COG0154	amidase activity
KFF05_05410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KFF05_05415	COG0456	acetyltransferase
KFF05_05420	COG2205	protein histidine kinase activity
KFF05_05435	COG0647	UMP catabolic process
KFF05_05455	COG2175	clavaminate synthase activity
KFF05_05470	COG1414	Transcriptional regulator
KFF05_05475	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_05480	COG2853	Lipoprotein
KFF05_05495	COG0625	glutathione transferase activity
KFF05_05500	COG0442	prolyl-tRNA aminoacylation
KFF05_05515	COG1414	Transcriptional regulator
KFF05_05535	COG0640	Transcriptional regulator
KFF05_05565	COG1595	DNA-templated transcription, initiation
KFF05_05570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF05_05580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFF05_05595	COG1741	Belongs to the pirin family
KFF05_05605	COG0457	Tetratricopeptide repeat
KFF05_05615	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_05650	COG0501	Belongs to the peptidase M48B family
KFF05_05660	COG0436	Aminotransferase
KFF05_05665	COG1530	ribonuclease E activity
KFF05_05690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KFF05_05695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KFF05_05720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KFF05_05725	COG2945	thiolester hydrolase activity
KFF05_05730	COG1045	serine acetyltransferase
KFF05_05735	COG1959	2 iron, 2 sulfur cluster binding
KFF05_05740	COG1104	cysteine desulfurase activity
KFF05_05750	COG0822	iron-sulfur transferase activity
KFF05_05755	COG0316	Belongs to the HesB IscA family
KFF05_05760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KFF05_05765	COG0443	Heat shock 70 kDa protein
KFF05_05790	COG0482	sulfurtransferase activity
KFF05_05805	COG5265	(ABC) transporter
KFF05_05810	COG0745	RESPONSE REGULATOR receiver
KFF05_05835	COG0519	Catalyzes the synthesis of GMP from XMP
KFF05_05880	COG1116	anion transmembrane transporter activity
KFF05_05885	COG0390	transport system, permease component
KFF05_05895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KFF05_05925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFF05_05925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFF05_05980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFF05_05980	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KFF05_05985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFF05_05990	COG0534	Mate efflux family protein
KFF05_06025	COG2086	electron transfer activity
KFF05_06030	COG2205	protein histidine kinase activity
KFF05_06045	COG0577	efflux transmembrane transporter activity
KFF05_06045	COG1136	(ABC) transporter
KFF05_06070	COG0583	DNA-binding transcription factor activity
KFF05_06075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_06080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KFF05_06085	COG0471	metal ion transport
KFF05_06085	COG3273	potassium ion transport
KFF05_06095	COG0583	DNA-binding transcription factor activity
KFF05_06155	COG0538	isocitrate dehydrogenase activity
KFF05_06160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KFF05_06165	COG0156	8-amino-7-oxononanoate synthase activity
KFF05_06175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KFF05_06180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KFF05_06240	COG0517	IMP dehydrogenase activity
KFF05_06240	COG0516	GMP reductase activity
KFF05_06245	COG4536	flavin adenine dinucleotide binding
KFF05_06250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFF05_06270	COG4974	Belongs to the 'phage' integrase family
KFF05_06350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF05_06355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KFF05_06380	COG1058	Belongs to the CinA family
KFF05_06380	COG1546	Belongs to the CinA family
KFF05_06385	COG0778	Nitroreductase
KFF05_06420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_06425	COG0148	phosphopyruvate hydratase activity
KFF05_06445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_06450	COG1396	sequence-specific DNA binding
KFF05_06465	COG3842	ATPase activity
KFF05_06470	COG0235	Class ii aldolase
KFF05_06480	COG2205	protein histidine kinase activity
KFF05_06480	COG2202	Pas domain
KFF05_06495	COG2205	protein histidine kinase activity
KFF05_06520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KFF05_06530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KFF05_06535	COG2414	aldehyde ferredoxin oxidoreductase
KFF05_06560	COG1160	GTP binding
KFF05_06620	COG0840	transmembrane signaling receptor activity
KFF05_06635	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_06640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KFF05_06670	COG1127	ABC transporter
KFF05_06675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KFF05_06680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KFF05_06685	COG0305	Participates in initiation and elongation during chromosome replication
KFF05_06690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KFF05_06695	COG0359	binds to the 23S rRNA
KFF05_06705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KFF05_06720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KFF05_06735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KFF05_06740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KFF05_06750	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_06755	COG0300	oxidoreductase activity
KFF05_06760	COG1561	YicC-like family, N-terminal region
KFF05_06800	COG1960	acyl-CoA dehydrogenase activity
KFF05_06805	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KFF05_06820	COG3616	Alanine racemase, N-terminal domain
KFF05_06830	COG3022	response to hydroperoxide
KFF05_06835	COG1393	Belongs to the ArsC family
KFF05_06865	COG2207	Transcriptional regulator
KFF05_06875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KFF05_06880	COG0009	L-threonylcarbamoyladenylate synthase
KFF05_06890	COG1355	regulation of microtubule-based process
KFF05_06910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KFF05_06930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_06935	COG2301	Belongs to the HpcH HpaI aldolase family
KFF05_06940	COG0861	Integral membrane protein TerC family
KFF05_06950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF05_06965	COG1414	Transcriptional regulator
KFF05_06975	COG2814	Major facilitator Superfamily
KFF05_06985	COG0488	(ABC) transporter
KFF05_06995	COG0105	UTP biosynthetic process
KFF05_07000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KFF05_07005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KFF05_07015	COG0628	permease
KFF05_07030	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_07035	COG0745	RESPONSE REGULATOR receiver
KFF05_07040	COG0840	transmembrane signaling receptor activity
KFF05_07050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KFF05_07065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KFF05_07075	COG1024	Enoyl-CoA hydratase
KFF05_07090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KFF05_07110	COG1940	carbohydrate kinase activity
KFF05_07130	COG1309	transcriptional regulator
KFF05_07165	COG3246	L-lysine catabolic process to acetate
KFF05_07170	COG0640	Transcriptional regulator
KFF05_07175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFF05_07190	COG0123	including yeast histone deacetylase and acetoin utilization protein
KFF05_07200	COG0142	geranyltranstransferase activity
KFF05_07205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KFF05_07210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KFF05_07235	COG4948	Mandelate Racemase Muconate Lactonizing
KFF05_07240	COG0583	DNA-binding transcription factor activity
KFF05_07245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KFF05_07250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KFF05_07255	COG1295	ribonuclease BN
KFF05_07265	COG4520	surface antigen
KFF05_07270	COG0259	pyridoxamine-phosphate oxidase activity
KFF05_07290	COG2135	peptidase activity
KFF05_07295	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_07310	COG1648	precorrin-2 dehydrogenase activity
KFF05_07310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KFF05_07315	COG1612	heme a metabolic process
KFF05_07325	COG0793	Belongs to the peptidase S41A family
KFF05_07335	COG0175	sulfate reduction
KFF05_07340	COG0175	sulfate reduction
KFF05_07345	COG0243	molybdopterin cofactor binding
KFF05_07350	COG0437	4 iron, 4 sulfur cluster binding
KFF05_07355	COG3302	dmso reductase anchor subunit
KFF05_07380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KFF05_07405	COG0534	Mate efflux family protein
KFF05_07430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KFF05_07455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFF05_07465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KFF05_07480	COG0222	ribosome binding
KFF05_07490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KFF05_07495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KFF05_07510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KFF05_07515	COG0051	transcription antitermination factor activity, RNA binding
KFF05_07520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KFF05_07540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KFF05_07550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KFF05_07555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KFF05_07560	COG0255	Belongs to the universal ribosomal protein uL29 family
KFF05_07565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KFF05_07570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KFF05_07575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KFF05_07580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KFF05_07585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KFF05_07595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KFF05_07600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KFF05_07605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KFF05_07610	COG1841	ribosomal large subunit assembly
KFF05_07620	COG0201	protein transport
KFF05_07625	COG0563	adenylate kinase activity
KFF05_07630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KFF05_07645	COG0203	ribosomal protein L17
KFF05_07650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFF05_07655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KFF05_07660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KFF05_07670	COG0745	RESPONSE REGULATOR receiver
KFF05_07680	COG0642	Histidine kinase
KFF05_07685	COG2885	chlorophyll binding
KFF05_07685	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KFF05_07710	COG2201	protein-glutamate methylesterase activity
KFF05_07715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KFF05_07730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_07750	COG2081	HI0933 family
KFF05_07760	COG2249	NAD(P)H dehydrogenase (quinone) activity
KFF05_07770	COG0471	metal ion transport
KFF05_07780	COG4770	biotin carboxylase activity
KFF05_07785	COG1254	Belongs to the acylphosphatase family
KFF05_07820	COG2239	Acts as a magnesium transporter
KFF05_07830	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
KFF05_07850	COG0183	Belongs to the thiolase family
KFF05_07870	COG1024	Enoyl-CoA hydratase
KFF05_07875	COG3437	response regulator, receiver
KFF05_07895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFF05_07910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFF05_07915	COG0601	transmembrane transport
KFF05_07925	COG4166	transmembrane transport
KFF05_07930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KFF05_07935	COG0457	Tetratricopeptide repeat
KFF05_08005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFF05_08010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF05_08035	COG4964	Belongs to the GSP D family
KFF05_08070	COG1846	Transcriptional regulator
KFF05_08075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KFF05_08080	COG1960	acyl-CoA dehydrogenase activity
KFF05_08095	COG1073	alpha beta
KFF05_08130	COG0410	ABC transporter
KFF05_08140	COG0129	dihydroxy-acid dehydratase activity
KFF05_08150	COG2308	Evidence 4 Homologs of previously reported genes of
KFF05_08160	COG1305	Transglutaminase-like
KFF05_08165	COG0651	ATP synthesis coupled electron transport
KFF05_08175	COG0651	ATP synthesis coupled electron transport
KFF05_08180	COG0651	ATP synthesis coupled electron transport
KFF05_08185	COG1006	Multisubunit Na H antiporter MnhC subunit
KFF05_08205	COG2212	antiporter activity
KFF05_08210	COG1863	multisubunit Na H antiporter MnhE subunit
KFF05_08255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KFF05_08280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFF05_08280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KFF05_08285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFF05_08285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KFF05_08290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KFF05_08300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF05_08310	COG0583	DNA-binding transcription factor activity
KFF05_08320	COG2095	MarC family integral membrane protein
KFF05_08325	COG0523	cobalamin synthesis protein
KFF05_08330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KFF05_08335	COG0626	cystathionine gamma-synthase activity
KFF05_08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KFF05_08345	COG4597	amino acid ABC transporter
KFF05_08350	COG0765	amino acid transport
KFF05_08355	COG1126	abc transporter atp-binding protein
KFF05_08370	COG2897	thiosulfate sulfurtransferase activity
KFF05_08380	COG1024	Enoyl-CoA hydratase
KFF05_08385	COG0494	nUDIX hydrolase
KFF05_08405	COG2205	protein histidine kinase activity
KFF05_08405	COG2202	Pas domain
KFF05_08410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KFF05_08410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KFF05_08445	COG0776	regulation of translation
KFF05_08460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KFF05_08465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KFF05_08480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KFF05_08485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KFF05_08490	COG1034	ATP synthesis coupled electron transport
KFF05_08495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KFF05_08500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KFF05_08510	COG0713	ATP synthesis coupled electron transport
KFF05_08525	COG1007	ATP synthesis coupled electron transport
KFF05_08545	COG0346	lactoylglutathione lyase activity
KFF05_08555	COG0442	prolyl-tRNA aminoacylation
KFF05_08585	COG1595	DNA-templated transcription, initiation
KFF05_08590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KFF05_08625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KFF05_08630	COG0528	UMP kinase activity
KFF05_08640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KFF05_08650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KFF05_08655	COG0750	zinc metalloprotease
KFF05_08660	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KFF05_08670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFF05_08675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KFF05_08690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KFF05_08695	COG0372	Belongs to the citrate synthase family
KFF05_08705	COG0658	competence protein
KFF05_08705	COG2333	competence protein COMEC
KFF05_08715	COG0303	'Molybdopterin
KFF05_08720	COG0315	cyclic pyranopterin monophosphate synthase activity
KFF05_08725	COG0134	indole-3-glycerol-phosphate synthase activity
KFF05_08730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KFF05_08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KFF05_08750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KFF05_08755	COG0149	triose-phosphate isomerase activity
KFF05_08760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KFF05_08775	COG0148	phosphopyruvate hydratase activity
KFF05_08795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KFF05_08800	COG0022	dehydrogenase e1 component
KFF05_08800	COG0508	dehydrogenase complex catalyzes the overall conversion of
KFF05_08810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFF05_08815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KFF05_08820	COG2867	negative regulation of translational initiation
KFF05_08825	COG1546	Belongs to the CinA family
KFF05_08830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KFF05_08835	COG0739	heme binding
KFF05_08865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFF05_08875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFF05_08880	COG0543	2 iron, 2 sulfur cluster binding
KFF05_08880	COG0633	Ferredoxin
KFF05_08885	COG0625	glutathione transferase activity
KFF05_08900	COG1573	uracil-dna glycosylase
KFF05_08915	COG1758	RNA polymerase activity
KFF05_08925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KFF05_08930	COG0736	holo-[acyl-carrier-protein] synthase activity
KFF05_08935	COG0681	Belongs to the peptidase S26 family
KFF05_08940	COG0571	ribonuclease III activity
KFF05_08945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KFF05_08950	COG1381	Involved in DNA repair and RecF pathway recombination
KFF05_08955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFF05_08970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KFF05_08975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFF05_08985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFF05_09005	COG0835	chemotaxis
KFF05_09010	COG0113	porphobilinogen synthase activity
KFF05_09025	COG0698	ribose 5-phosphate isomerase
KFF05_09035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KFF05_09040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFF05_09040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KFF05_09050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFF05_09050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KFF05_09065	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KFF05_09075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KFF05_09095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KFF05_09100	COG0416	fatty acid biosynthetic process
KFF05_09105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KFF05_09110	COG0776	regulation of translation
KFF05_09185	COG2204	response regulator
KFF05_09190	COG0569	domain protein
KFF05_09205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KFF05_09215	COG0483	inositol monophosphate 1-phosphatase activity
KFF05_09220	COG2084	Dehydrogenase
KFF05_09235	COG3956	TIGRFAM MazG family protein
KFF05_09245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KFF05_09260	COG0583	DNA-binding transcription factor activity
KFF05_09270	COG0321	lipoyl(octanoyl) transferase activity
KFF05_09270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KFF05_09275	COG0084	hydrolase, TatD family'
KFF05_09280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KFF05_09290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KFF05_09295	COG1686	Belongs to the peptidase S11 family
KFF05_09305	COG2951	lytic endotransglycosylase activity
KFF05_09310	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KFF05_09340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KFF05_09345	COG0515	serine threonine protein kinase
KFF05_09345	COG2815	serine threonine protein kinase
KFF05_09405	COG0840	transmembrane signaling receptor activity
KFF05_09425	COG0745	RESPONSE REGULATOR receiver
KFF05_09430	COG2203	Gaf domain
KFF05_09430	COG3706	GGDEF domain
KFF05_09430	COG4251	negative regulation of phosphorylation
KFF05_09430	COG5001	Diguanylate cyclase
KFF05_09435	COG2204	response regulator
KFF05_09440	COG0784	Response regulator, receiver
KFF05_09440	COG4191	Histidine kinase
KFF05_09455	COG0840	transmembrane signaling receptor activity
KFF05_09480	COG4139	cobalamin transport
KFF05_09485	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KFF05_09525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFF05_09530	COG2186	Transcriptional regulator
KFF05_09540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF05_09560	COG4796	Type ii and iii secretion system protein
KFF05_09575	COG0410	ABC transporter
KFF05_09605	COG0745	RESPONSE REGULATOR receiver
KFF05_09615	COG5002	protein histidine kinase activity
KFF05_09635	COG1802	Transcriptional regulator
KFF05_09640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_09645	COG1024	Enoyl-CoA hydratase
KFF05_09675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KFF05_09685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KFF05_09695	COG0596	Alpha beta hydrolase
KFF05_09705	COG1051	belongs to the nudix hydrolase family
KFF05_09705	COG1056	cytidyltransferase-related domain
KFF05_09715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KFF05_09720	COG1132	(ABC) transporter
KFF05_09735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFF05_09750	COG0730	response to heat
KFF05_09755	COG0730	response to heat
KFF05_09775	COG2186	Transcriptional regulator
KFF05_09785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KFF05_09790	COG3588	fructose-bisphosphate aldolase
KFF05_09800	COG0271	Belongs to the BolA IbaG family
KFF05_09805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF05_09830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KFF05_09855	COG0347	Belongs to the P(II) protein family
KFF05_09870	COG0667	Aldo Keto reductase
KFF05_09875	COG3263	regulation of cellular component size
KFF05_09905	COG0187	DNA topoisomerase II activity
KFF05_09915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KFF05_09925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KFF05_09930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KFF05_09940	COG1024	Enoyl-CoA hydratase
KFF05_09950	COG2873	o-acetylhomoserine
KFF05_09985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KFF05_10000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KFF05_10005	COG1494	fructose-1,6-bisphosphatase
KFF05_10015	COG0436	Aminotransferase
KFF05_10025	COG3243	poly(R)-hydroxyalkanoic acid synthase
KFF05_10050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KFF05_10050	COG4451	ribulose bisphosphate carboxylase, small
KFF05_10055	COG3433	isochorismatase activity
KFF05_10055	COG1535	isochorismatase
KFF05_10065	COG0513	Belongs to the DEAD box helicase family
KFF05_10080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KFF05_10085	COG0511	ligase activity, forming carbon-carbon bonds
KFF05_10095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KFF05_10120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KFF05_10125	COG0745	RESPONSE REGULATOR receiver
KFF05_10165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_10175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KFF05_10185	COG1686	Belongs to the peptidase S11 family
KFF05_10195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KFF05_10215	COG1192	Involved in chromosome partitioning
KFF05_10220	COG0243	molybdopterin cofactor binding
KFF05_10225	COG2342	PFAM TM1410 hypothetical-related protein
KFF05_10230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFF05_10250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFF05_10270	COG3424	synthase
KFF05_10275	COG1755	Isoprenylcysteine carboxyl methyltransferase
KFF05_10280	COG3577	Aspartyl protease
KFF05_10290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KFF05_10310	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF05_10345	COG0583	DNA-binding transcription factor activity
KFF05_10370	COG4177	L-phenylalanine transmembrane transporter activity
KFF05_10390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KFF05_10395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KFF05_10400	COG2205	protein histidine kinase activity
KFF05_10400	COG2202	Pas domain
KFF05_10405	COG0629	single-stranded DNA binding
KFF05_10440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KFF05_10470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_10505	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KFF05_10540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KFF05_10545	COG1862	Preprotein translocase
KFF05_10580	COG0805	protein transport
KFF05_10585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFF05_10590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KFF05_10595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KFF05_10600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KFF05_10605	COG1994	Peptidase M50
KFF05_10610	COG1472	Belongs to the glycosyl hydrolase 3 family
KFF05_10620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KFF05_10630	COG0316	Belongs to the HesB IscA family
KFF05_10645	COG0519	Catalyzes the synthesis of GMP from XMP
KFF05_10650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFF05_10655	COG0501	Belongs to the peptidase M48B family
KFF05_10665	COG2175	clavaminate synthase activity
KFF05_10690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KFF05_10695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KFF05_10700	COG0129	dihydroxy-acid dehydratase activity
KFF05_10710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KFF05_10725	COG0668	transmembrane transport
KFF05_10730	COG0525	valine-tRNA ligase activity
KFF05_10745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KFF05_10765	COG0745	RESPONSE REGULATOR receiver
KFF05_10770	COG1366	Belongs to the anti-sigma-factor antagonist family
KFF05_10785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KFF05_10830	COG1234	tRNA 3'-trailer cleavage
KFF05_10840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KFF05_10880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KFF05_10885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_10890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KFF05_10895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFF05_10910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KFF05_10915	COG1562	ergosterol biosynthetic process
KFF05_10925	COG1562	ergosterol biosynthetic process
KFF05_10940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KFF05_10945	COG0277	FAD linked oxidase domain protein
KFF05_10965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFF05_10970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFF05_10975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_10995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_11010	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_11015	COG1012	belongs to the aldehyde dehydrogenase family
KFF05_11020	COG2205	protein histidine kinase activity
KFF05_11030	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
KFF05_11030	COG0028	Belongs to the TPP enzyme family
KFF05_11065	COG2204	response regulator
KFF05_11075	COG0625	glutathione transferase activity
KFF05_11110	COG1024	Enoyl-CoA hydratase
KFF05_11135	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFF05_11140	COG1696	Membrane protein involved in D-alanine export
KFF05_11150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFF05_11155	COG0473	3-isopropylmalate dehydrogenase activity
KFF05_11160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KFF05_11165	COG0066	3-isopropylmalate dehydratase activity
KFF05_11170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFF05_11175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_11180	COG1960	acyl-CoA dehydrogenase activity
KFF05_11195	COG2079	MmgE PrpD family protein
KFF05_11200	COG0583	DNA-binding transcription factor activity
KFF05_11205	COG0515	serine threonine protein kinase
KFF05_11205	COG2815	serine threonine protein kinase
KFF05_11215	COG3622	Belongs to the hyi family
KFF05_11220	COG0347	Belongs to the P(II) protein family
KFF05_11225	COG0004	ammonium transporteR
KFF05_11230	COG1024	Enoyl-CoA hydratase
KFF05_11235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_11250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KFF05_11270	COG1024	Enoyl-CoA hydratase
KFF05_11275	COG2159	amidohydrolase
KFF05_11280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KFF05_11285	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_11290	COG2301	Belongs to the HpcH HpaI aldolase family
KFF05_11300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KFF05_11305	COG0601	transmembrane transport
KFF05_11315	COG4608	Belongs to the ABC transporter superfamily
KFF05_11320	COG0444	Belongs to the ABC transporter superfamily
KFF05_11340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KFF05_11345	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KFF05_11360	COG2223	nitrite transmembrane transporter activity
KFF05_11375	COG0251	oxidation-reduction process
KFF05_11385	COG1960	acyl-CoA dehydrogenase activity
KFF05_11390	COG0456	acetyltransferase
KFF05_11395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KFF05_11400	COG1917	Cupin 2, conserved barrel domain protein
KFF05_11420	COG0156	8-amino-7-oxononanoate synthase activity
KFF05_11445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFF05_11455	COG1047	Peptidyl-prolyl cis-trans
KFF05_11475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_11485	COG0123	including yeast histone deacetylase and acetoin utilization protein
KFF05_11495	COG0163	prenyltransferase activity
KFF05_11510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_11520	COG0640	Transcriptional regulator
KFF05_11525	COG1902	pentaerythritol trinitrate reductase activity
KFF05_11535	COG0583	DNA-binding transcription factor activity
KFF05_11580	COG1120	ATPase activity
KFF05_11585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFF05_11590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KFF05_11600	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFF05_11610	COG2175	clavaminate synthase activity
KFF05_11665	COG2828	Protein conserved in bacteria
KFF05_11695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFF05_11700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFF05_11705	COG0352	thiamine-phosphate diphosphorylase activity
KFF05_11705	COG0351	phosphomethylpyrimidine kinase
KFF05_11710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KFF05_11715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KFF05_11725	COG0037	tRNA processing
KFF05_11735	COG2885	chlorophyll binding
KFF05_11750	COG0848	biopolymer transport protein
KFF05_11760	COG0824	Thioesterase
KFF05_11780	COG0217	transcriptional regulatory protein
KFF05_11785	COG1692	metallophosphoesterase
KFF05_11790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFF05_11815	COG0352	thiamine-phosphate diphosphorylase activity
KFF05_11820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KFF05_11825	COG0483	inositol monophosphate 1-phosphatase activity
KFF05_11840	COG1360	Flagellar Motor Protein
KFF05_11855	COG0254	rRNA binding
KFF05_11865	COG0071	Belongs to the small heat shock protein (HSP20) family
KFF05_11875	COG0824	Thioesterase
KFF05_11890	COG0604	alcohol dehydrogenase
KFF05_11890	COG3321	synthase
KFF05_11890	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_11900	COG1024	Enoyl-CoA hydratase
KFF05_11910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_11915	COG2186	Transcriptional regulator
KFF05_11920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KFF05_11935	COG0318	PFAM AMP-dependent synthetase and ligase
KFF05_11945	COG0205	6-phosphofructokinase activity
KFF05_11955	COG0386	Belongs to the glutathione peroxidase family
KFF05_11960	COG0659	secondary active sulfate transmembrane transporter activity
KFF05_11965	COG0513	Belongs to the DEAD box helicase family
KFF05_11980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KFF05_11995	COG0242	peptide deformylase activity
KFF05_12035	COG0251	oxidation-reduction process
KFF05_12045	COG0393	Putative heavy-metal-binding
KFF05_12080	COG0596	Alpha beta hydrolase
KFF05_12110	COG0469	pyruvate kinase activity
KFF05_12125	COG1703	isobutyryl-CoA mutase activity
KFF05_12150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KFF05_12150	COG3264	Mechanosensitive ion channel
KFF05_12160	COG3604	Transcriptional regulator
KFF05_12180	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KFF05_12195	COG1677	Flagellar hook-basal body complex protein FliE
KFF05_12200	COG1558	bacterial-type flagellum-dependent cell motility
KFF05_12205	COG1815	bacterial-type flagellum-dependent cell motility
KFF05_12225	COG1338	Plays a role in the flagellum-specific transport system
KFF05_12250	COG1360	Flagellar Motor Protein
KFF05_12290	COG4786	Flagellar basal body rod
KFF05_12295	COG4786	Flagellar basal body rod
KFF05_12305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KFF05_12310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KFF05_12325	COG1840	ABC-type Fe3 transport system, periplasmic component
KFF05_12335	COG3842	ATPase activity
KFF05_12340	COG4786	Flagellar basal body rod
KFF05_12415	COG2089	acid synthase
KFF05_12425	COG0367	asparagine synthase
KFF05_12435	COG0673	inositol 2-dehydrogenase activity
KFF05_12440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFF05_12460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_12470	COG0107	imidazoleglycerol-phosphate synthase activity
KFF05_12490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFF05_12500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFF05_12505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFF05_12525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KFF05_12530	COG1749	Flagellar hook protein flgE
KFF05_12540	COG1766	The M ring may be actively involved in energy transduction
KFF05_12545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFF05_12555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KFF05_12560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KFF05_12565	COG2204	response regulator
KFF05_12570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KFF05_12575	COG0552	protein localization to endoplasmic reticulum
KFF05_12590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KFF05_12605	COG0745	RESPONSE REGULATOR receiver
KFF05_12610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KFF05_12615	COG2201	protein-glutamate methylesterase activity
KFF05_12620	COG0745	RESPONSE REGULATOR receiver
KFF05_12625	COG0643	Histidine kinase
KFF05_12625	COG0784	Response regulator, receiver
KFF05_12625	COG2198	Histidine kinase
KFF05_12640	COG3383	formate dehydrogenase (NAD+) activity
KFF05_12650	COG2864	formate dehydrogenase
KFF05_12660	COG0437	4 iron, 4 sulfur cluster binding
KFF05_12665	COG3383	formate dehydrogenase (NAD+) activity
KFF05_12690	COG0746	molybdenum cofactor guanylyltransferase activity
KFF05_12695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KFF05_12700	COG0406	alpha-ribazole phosphatase activity
KFF05_12730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KFF05_12750	COG2814	Major facilitator Superfamily
KFF05_12770	COG0167	dihydroorotate dehydrogenase activity
KFF05_12810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KFF05_12810	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
KFF05_12820	COG2198	Histidine kinase
KFF05_12820	COG0784	Response regulator, receiver
KFF05_12820	COG2205	protein histidine kinase activity
KFF05_12825	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_12830	COG0121	glutamine amidotransferase
KFF05_12845	COG0513	Belongs to the DEAD box helicase family
KFF05_12875	COG2205	protein histidine kinase activity
KFF05_12880	COG0183	Belongs to the thiolase family
KFF05_12885	COG1024	Enoyl-CoA hydratase
KFF05_12885	COG1250	3-hydroxyacyl-CoA dehydrogenase
KFF05_12890	COG0028	Belongs to the TPP enzyme family
KFF05_12895	COG0318	PFAM AMP-dependent synthetase and ligase
KFF05_12900	COG1960	acyl-CoA dehydrogenase activity
KFF05_12915	COG1278	Cold shock
KFF05_12935	COG2202	Pas domain
KFF05_12935	COG2205	protein histidine kinase activity
KFF05_12980	COG3647	Membrane
KFF05_12985	COG1960	acyl-CoA dehydrogenase activity
KFF05_12990	COG1960	acyl-CoA dehydrogenase activity
KFF05_13015	COG0004	ammonium transporteR
KFF05_13020	COG2814	Major facilitator Superfamily
KFF05_13060	COG0604	alcohol dehydrogenase
KFF05_13065	COG0418	dihydroorotase activity
KFF05_13070	COG0367	asparagine synthase
KFF05_13075	COG0438	transferase activity, transferring glycosyl groups
KFF05_13105	COG0154	amidase activity
KFF05_13115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KFF05_13120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFF05_13125	COG1414	Transcriptional regulator
KFF05_13135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KFF05_13165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_13170	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KFF05_13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KFF05_13175	COG0574	Belongs to the PEP-utilizing enzyme family
KFF05_13180	COG0751	glycine-tRNA ligase activity
KFF05_13185	COG0752	glycyl-tRNA synthetase alpha subunit
KFF05_13205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFF05_13215	COG0142	geranyltranstransferase activity
KFF05_13250	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KFF05_13260	COG3474	cytochrome
KFF05_13265	COG2358	TRAP transporter, solute receptor (TAXI family
KFF05_13280	COG2358	TRAP transporter, solute receptor (TAXI family
KFF05_13290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KFF05_13300	COG0454	-acetyltransferase
KFF05_13310	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KFF05_13315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KFF05_13320	COG1196	nuclear chromosome segregation
KFF05_13340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KFF05_13350	COG0010	Belongs to the arginase family
KFF05_13360	COG0019	diaminopimelate decarboxylase activity
KFF05_13370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KFF05_13380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KFF05_13390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KFF05_13395	COG0849	cell division
KFF05_13405	COG1181	Belongs to the D-alanine--D-alanine ligase family
KFF05_13410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KFF05_13415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KFF05_13430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KFF05_13445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KFF05_13460	COG0275	rRNA processing
KFF05_13465	COG2001	Belongs to the MraZ family
KFF05_13475	COG3023	N-Acetylmuramoyl-L-alanine amidase
KFF05_13480	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KFF05_13495	COG1053	succinate dehydrogenase
KFF05_13495	COG3976	FMN-binding domain protein
KFF05_13500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_13515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KFF05_13530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_13535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KFF05_13540	COG0179	Fumarylacetoacetate (FAA) hydrolase
KFF05_13550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KFF05_13555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFF05_13560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KFF05_13590	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
KFF05_13595	COG4778	phosphonate C-P lyase system protein PhnL
KFF05_13600	COG4107	phosphonate C-P lyase system protein PhnK
KFF05_13605	COG3627	carbon phosphorus lyase activity
KFF05_13610	COG3626	phosphonate metabolism
KFF05_13615	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
KFF05_13620	COG3624	Phosphonate C-P lyase system protein PhnG
KFF05_13625	COG2188	Transcriptional regulator
KFF05_13630	COG3454	Phosphonate metabolism
KFF05_13640	COG3639	organic phosphonate transmembrane transporter activity
KFF05_13645	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KFF05_13675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KFF05_13695	COG0772	Belongs to the SEDS family
KFF05_13715	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KFF05_13730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KFF05_13760	COG0028	Belongs to the TPP enzyme family
KFF05_13765	COG0745	RESPONSE REGULATOR receiver
KFF05_13770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KFF05_13775	COG0560	Phosphoserine phosphatase
KFF05_13775	COG3830	Belongs to the UPF0237 family
KFF05_13780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KFF05_13795	COG0330	HflC and HflK could
KFF05_13820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KFF05_13825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KFF05_13840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KFF05_13840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KFF05_13850	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_13910	COG5002	protein histidine kinase activity
KFF05_13915	COG0277	FAD linked oxidase domain protein
KFF05_13920	COG0457	Tetratricopeptide repeat
KFF05_13930	COG0247	lactate metabolic process
KFF05_13935	COG0277	FAD linked oxidase domain protein
KFF05_13940	COG0277	FAD linked oxidase domain protein
KFF05_13945	COG2084	Dehydrogenase
KFF05_13950	COG3622	Belongs to the hyi family
KFF05_13955	COG3960	tartronate-semialdehyde synthase activity
KFF05_13960	COG1414	Transcriptional regulator
KFF05_13965	COG2226	methyltransferase
KFF05_13970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KFF05_14000	COG1960	acyl-CoA dehydrogenase activity
KFF05_14015	COG2274	protein secretion by the type I secretion system
KFF05_14030	COG1396	sequence-specific DNA binding
KFF05_14040	COG0154	amidase activity
KFF05_14045	COG2358	TRAP transporter, solute receptor (TAXI family
KFF05_14055	COG1802	Transcriptional regulator
KFF05_14080	COG0318	PFAM AMP-dependent synthetase and ligase
KFF05_14090	COG1396	sequence-specific DNA binding
KFF05_14100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KFF05_14120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KFF05_14125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KFF05_14150	COG0640	Transcriptional regulator
KFF05_14170	COG1121	(ABC) transporter
KFF05_14175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KFF05_14190	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_14200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFF05_14235	COG0318	PFAM AMP-dependent synthetase and ligase
KFF05_14275	COG3395	kinase activity
KFF05_14280	COG0235	Class ii aldolase
KFF05_14320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KFF05_14335	COG4774	siderophore transport
KFF05_14345	COG1595	DNA-templated transcription, initiation
KFF05_14370	COG4774	siderophore transport
KFF05_14395	COG0848	biopolymer transport protein
KFF05_14400	COG0811	peptide transport
KFF05_14410	COG4772	TonB-dependent receptor
KFF05_14435	COG4774	siderophore transport
KFF05_14500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KFF05_14515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KFF05_14520	COG0583	DNA-binding transcription factor activity
KFF05_14525	COG1959	2 iron, 2 sulfur cluster binding
KFF05_14550	COG3707	response regulator
KFF05_14555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KFF05_14560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF05_14580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KFF05_14585	COG2146	nitrite reductase [NAD(P)H] activity
KFF05_14590	COG0243	molybdopterin cofactor binding
KFF05_14595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KFF05_14595	COG1648	precorrin-2 dehydrogenase activity
KFF05_14620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KFF05_14640	COG1120	ATPase activity
KFF05_14645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KFF05_14665	COG0582	viral genome integration into host DNA
KFF05_14720	COG1742	UPF0060 membrane protein
KFF05_14755	COG0739	heme binding
KFF05_14760	COG0596	Alpha beta hydrolase
KFF05_14780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFF05_14785	COG0542	response to heat
KFF05_14800	COG2890	protein-(glutamine-N5) methyltransferase activity
KFF05_14810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KFF05_14815	COG0124	histidyl-tRNA synthetase
KFF05_14820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KFF05_14825	COG1426	Protein conserved in bacteria
KFF05_14830	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
KFF05_14835	COG0527	aspartate kinase activity
KFF05_14840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KFF05_14885	COG2885	chlorophyll binding
KFF05_14885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KFF05_14890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KFF05_14895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KFF05_14900	COG1040	competence protein
KFF05_14905	COG2226	methyltransferase
KFF05_14910	COG1489	DNA binding
KFF05_14915	COG0024	Methionine aminopeptidase
KFF05_14920	COG2003	Belongs to the UPF0758 family
KFF05_14925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KFF05_14945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KFF05_14980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KFF05_15000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KFF05_15005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFF05_15010	COG0047	phosphoribosylformylglycinamidine synthase activity
KFF05_15015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFF05_15025	COG2079	MmgE PrpD family protein
KFF05_15040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KFF05_15060	COG3634	alkyl hydroperoxide reductase activity
KFF05_15070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KFF05_15075	COG3842	ATPase activity
KFF05_15100	COG1012	belongs to the aldehyde dehydrogenase family
KFF05_15115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KFF05_15125	COG3842	ATPase activity
KFF05_15130	COG1840	ABC-type Fe3 transport system, periplasmic component
KFF05_15135	COG0583	DNA-binding transcription factor activity
KFF05_15150	COG0174	glutamine synthetase
KFF05_15160	COG1012	belongs to the aldehyde dehydrogenase family
KFF05_15165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KFF05_15200	COG2132	Multicopper oxidase
KFF05_15225	COG0400	carboxylic ester hydrolase activity
KFF05_15230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KFF05_15240	COG4783	chaperone-mediated protein folding
KFF05_15255	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KFF05_15270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KFF05_15280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KFF05_15295	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KFF05_15305	COG1022	Amp-dependent synthetase and ligase
KFF05_15350	COG4133	protoheme IX ABC transporter activity
KFF05_15360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KFF05_15370	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KFF05_15375	COG1138	Cytochrome C-type biogenesis protein
KFF05_15380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KFF05_15385	COG3088	subunit of a heme lyase
KFF05_15390	COG4235	cytochrome complex assembly
KFF05_15395	COG0126	phosphoglycerate kinase activity
KFF05_15450	COG0154	amidase activity
KFF05_15460	COG0552	protein localization to endoplasmic reticulum
KFF05_15465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFF05_15470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KFF05_15485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KFF05_15490	COG0228	four-way junction DNA binding
KFF05_15495	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KFF05_15510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KFF05_15515	COG0066	3-isopropylmalate dehydratase activity
KFF05_15525	COG2205	protein histidine kinase activity
KFF05_15530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KFF05_15540	COG2132	Multicopper oxidase
KFF05_15545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KFF05_15585	COG2301	Belongs to the HpcH HpaI aldolase family
KFF05_15590	COG2030	dehydratase
KFF05_15620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KFF05_15630	COG2808	Putative FMN-binding domain
KFF05_15645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KFF05_15650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KFF05_15665	COG0039	L-malate dehydrogenase activity
KFF05_15690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KFF05_15700	COG4974	Belongs to the 'phage' integrase family
KFF05_15715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KFF05_15725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KFF05_15750	COG0556	nucleotide-excision repair
KFF05_15775	COG0436	Aminotransferase
KFF05_15790	COG1522	sequence-specific DNA binding
KFF05_15800	COG0583	DNA-binding transcription factor activity
KFF05_15805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KFF05_15815	COG0302	gtp cyclohydrolase
KFF05_15820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KFF05_15845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KFF05_15850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KFF05_15855	COG0842	Transport permease protein
KFF05_15860	COG2137	regulation of response to DNA damage stimulus
KFF05_15875	COG0189	ligase activity
KFF05_15885	COG0668	transmembrane transport
KFF05_15890	COG1393	Belongs to the ArsC family
KFF05_15935	COG1131	(ABC) transporter
KFF05_15940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KFF05_15950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KFF05_15970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_15970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KFF05_15990	COG1063	alcohol dehydrogenase
KFF05_15995	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KFF05_16000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KFF05_16005	COG1238	metal cluster binding
KFF05_16010	COG2175	clavaminate synthase activity
KFF05_16020	COG0745	RESPONSE REGULATOR receiver
KFF05_16035	COG1522	sequence-specific DNA binding
KFF05_16070	COG2030	dehydratase
KFF05_16075	COG0196	riboflavin kinase activity
KFF05_16080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KFF05_16095	COG0612	Peptidase, M16
KFF05_16100	COG0612	Peptidase, M16
KFF05_16105	COG0166	Belongs to the GPI family
KFF05_16110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KFF05_16120	COG0742	ribosomal rna small subunit methyltransferase
KFF05_16125	COG1187	pseudouridine synthase activity
KFF05_16130	COG0590	tRNA wobble adenosine to inosine editing
KFF05_16150	COG1570	exodeoxyribonuclease VII activity
KFF05_16155	COG0739	heme binding
KFF05_16180	COG1132	(ABC) transporter
KFF05_16195	COG1597	lipid kinase activity
KFF05_16205	COG2130	NADP-dependent
KFF05_16210	COG0312	modulator of DNA gyrase
KFF05_16215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KFF05_16215	COG0674	pyruvate-flavodoxin oxidoreductase activity
KFF05_16220	COG1013	pyruvate-flavodoxin oxidoreductase activity
KFF05_16225	COG0493	'glutamate synthase
KFF05_16250	COG0312	modulator of DNA gyrase
KFF05_16265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KFF05_16270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KFF05_16295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KFF05_16300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KFF05_16340	COG2875	Belongs to the precorrin methyltransferase family
KFF05_16350	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KFF05_16355	COG2116	formate transmembrane transporter activity
KFF05_16360	COG1999	signal sequence binding
KFF05_16365	COG1797	cobyrinic acid a,c-diamide synthase activity
KFF05_16370	COG2983	Belongs to the UPF0260 family
KFF05_16375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KFF05_16385	COG2169	Transcriptional regulator
KFF05_16385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KFF05_16395	COG0432	Pfam Uncharacterised protein family UPF0047
KFF05_16420	COG0582	viral genome integration into host DNA
KFF05_16440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KFF05_16460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KFF05_16470	COG1131	(ABC) transporter
KFF05_16480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFF05_16480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KFF05_16490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KFF05_16495	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KFF05_16500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KFF05_16540	COG3773	Cell wall hydrolase
KFF05_16690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KFF05_16695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KFF05_16715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFF05_16715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KFF05_16785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KFF05_16790	COG0277	FAD linked oxidase domain protein
KFF05_16790	COG0247	lactate metabolic process
KFF05_16795	COG1802	Transcriptional regulator
KFF05_16800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KFF05_16815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KFF05_16820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KFF05_16830	COG2205	protein histidine kinase activity
KFF05_16845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFF05_16850	COG0583	DNA-binding transcription factor activity
KFF05_16855	COG1024	Enoyl-CoA hydratase
KFF05_16865	COG0583	DNA-binding transcription factor activity
KFF05_16885	COG4251	negative regulation of phosphorylation
KFF05_16890	COG0604	alcohol dehydrogenase
KFF05_16910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KFF05_16920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KFF05_16935	COG0137	argininosuccinate synthase activity
KFF05_16945	COG2175	clavaminate synthase activity
KFF05_16950	COG0583	DNA-binding transcription factor activity
KFF05_16960	COG1573	uracil-dna glycosylase
KFF05_16975	COG3474	cytochrome
KFF05_16980	COG2992	FlgJ-related protein
KFF05_16985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KFF05_16990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KFF05_16995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KFF05_17015	COG1136	(ABC) transporter
KFF05_17025	COG0670	Belongs to the BI1 family
KFF05_17060	COG2192	nodulation
KFF05_17090	COG0181	hydroxymethylbilane synthase activity
KFF05_17095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KFF05_17100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KFF05_17115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KFF05_17130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KFF05_17140	COG1396	sequence-specific DNA binding
KFF05_17140	COG3800	Transcriptional regulator
KFF05_17165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KFF05_17165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KFF05_17175	COG3307	-O-antigen
KFF05_17180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KFF05_17205	COG0250	Participates in transcription elongation, termination and antitermination
KFF05_17210	COG1083	cytidylyl-transferase
KFF05_17215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_17220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFF05_17225	COG2089	acid synthase
KFF05_17235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KFF05_17240	COG0107	imidazoleglycerol-phosphate synthase activity
KFF05_17245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFF05_17265	COG0529	Catalyzes the synthesis of activated sulfate
KFF05_17270	COG2046	Belongs to the sulfate adenylyltransferase family
KFF05_17280	COG1086	Polysaccharide biosynthesis protein
KFF05_17285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KFF05_17290	COG1132	(ABC) transporter
KFF05_17295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KFF05_17315	COG0469	pyruvate kinase activity
KFF05_17320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KFF05_17330	COG0463	Glycosyl transferase, family 2
KFF05_17360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KFF05_17365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KFF05_17370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KFF05_17400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KFF05_17405	COG3959	Transketolase, thiamine diphosphate binding domain
KFF05_17410	COG3958	Transketolase
KFF05_17420	COG2192	nodulation
KFF05_17430	COG2192	nodulation
KFF05_17445	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KFF05_17455	COG1247	-acetyltransferase
KFF05_17460	COG2089	acid synthase
KFF05_17480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KFF05_17490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KFF05_17495	COG1028	Short-chain dehydrogenase reductase Sdr
KFF05_17500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KFF05_17515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KFF05_17535	COG1215	transferase activity, transferring glycosyl groups
KFF05_17620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KFF05_17630	COG0138	bifunctional purine biosynthesis protein purh
KFF05_17635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KFF05_17640	COG2902	Dehydrogenase
KFF05_17665	COG2835	tetraacyldisaccharide 4'-kinase activity
KFF05_17690	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KFF05_17705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KFF05_17710	COG0347	Belongs to the P(II) protein family
KFF05_17715	COG0004	ammonium transporteR
KFF05_17720	COG0436	Aminotransferase
KFF05_17725	COG1674	ftsk spoiiie
KFF05_17740	COG2205	protein histidine kinase activity
KFF05_17770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KFF05_17775	COG0352	thiamine-phosphate diphosphorylase activity
KFF05_17775	COG0351	phosphomethylpyrimidine kinase
KFF05_17825	COG3411	Ferredoxin
KFF05_17835	COG1331	Highly conserved protein containing a thioredoxin domain
KFF05_17850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KFF05_17855	COG1981	membrane
KFF05_17865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KFF05_17875	COG0424	maF-like protein
KFF05_17890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KFF05_17895	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KFF05_17900	COG3030	protein affecting phage T7 exclusion by the F plasmid
KFF05_17910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KFF05_17915	COG0247	lactate metabolic process
KFF05_17920	COG1139	Iron-sulfur cluster binding protein
KFF05_17945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KFF05_17965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KFF05_17970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KFF05_17975	COG0107	imidazoleglycerol-phosphate synthase activity
KFF05_18030	COG0792	nuclease activity
KFF05_18035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KFF05_18050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KFF05_18055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KFF05_18060	COG1420	regulation of RNA biosynthetic process
KFF05_18065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KFF05_18085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KFF05_18095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KFF05_18115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KFF05_18120	COG1217	gtp-binding protein TYPA
KFF05_18125	COG0288	reversible hydration of carbon dioxide
KFF05_18140	COG0659	secondary active sulfate transmembrane transporter activity
KFF05_18150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KFF05_18155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KFF05_18160	COG0280	phosphate acetyltransferase
KFF05_18160	COG0281	malic enzyme
KFF05_18165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KFF05_18175	COG0728	peptidoglycan biosynthetic process
KFF05_18180	COG0180	Tryptophanyl-tRNA synthetase
KFF05_18185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KFF05_18190	COG2992	FlgJ-related protein
KFF05_18200	COG0778	Nitroreductase
KFF05_18210	COG1214	PFAM Peptidase M22, glycoprotease
KFF05_18220	COG4957	zinc ion binding
KFF05_18230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KFF05_18235	COG1702	phosphate starvation-inducible protein PhoH
KFF05_18250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KFF05_18255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KFF05_18260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KFF05_18290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KFF05_18295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KFF05_18315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KFF05_18325	COG1592	Rubrerythrin
KFF05_18355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KFF05_18365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KFF05_18370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KFF05_18375	COG1959	2 iron, 2 sulfur cluster binding
KFF05_18380	COG0756	dUTP diphosphatase activity
KFF05_18395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KFF05_18405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KFF05_18415	COG1024	Enoyl-CoA hydratase