locus-tag	class	description
D521_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
D521_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
D521_0003	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D521_0006	ENOG4105C0Z	ABC transporter
D521_0007	ENOG4108IV0	ABC, transporter
D521_0011	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
D521_0012	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
D521_0013	ENOG4107QJE	Chromosome Partitioning Protein
D521_0014	ENOG4105FA0	parb-like partition protein
D521_0016	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
D521_0017	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D521_0018	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D521_0019	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D521_0020	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
D521_0021	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
D521_0022	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
D521_0023	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
D521_0024	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
D521_0025	ENOG4105C25	Primosomal protein n'
D521_0026	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
D521_0027	ENOG4105C5X	domain protein
D521_0030	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
D521_0031	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
D521_0032	ENOG4105W4M	Transport-associated protein
D521_0033	ENOG4105W2Z	cytochrome C, class I
D521_0037	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
D521_0038	ENOG4105PM1	preprotein translocase subunit SecE
D521_0040	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
D521_0041	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
D521_0042	ENOG4108VZM	50s ribosomal protein L10
D521_0043	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
D521_0044	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D521_0045	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D521_0047	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
D521_0048	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
D521_0049	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
D521_0050	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
D521_0051	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
D521_0052	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
D521_0053	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
D521_0054	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
D521_0055	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D521_0056	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
D521_0057	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
D521_0058	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
D521_0059	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
D521_0061	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
D521_0062	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
D521_0063	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
D521_0064	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D521_0065	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
D521_0066	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
D521_0067	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
D521_0068	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
D521_0069	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
D521_0070	ENOG4105VPB	50S ribosomal protein L30
D521_0071	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
D521_0072	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
D521_0073	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
D521_0075	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D521_0076	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
D521_0077	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
D521_0078	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D521_0079	ENOG4108ZT0	50S ribosomal protein l17
D521_0081	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
D521_0082	ENOG4105D52	delta-aminolevulinic acid dehydratase
D521_0083	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
D521_0084	ENOG4106RE7	Cytochrome
D521_0085	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
D521_0086	ENOG4105XQ6	frataxin-like protein
D521_0087	ENOG4105D49	3-dehydroquinate synthase
D521_0091	ENOG4108JQC	penicillin-binding protein 1A
D521_0095	ENOG4105DHJ	ABC, transporter
D521_0096	ENOG4105CY3	ABC transporter, permease
D521_0097	ENOG4107PE3	Mammalian cell entry related domain protein
D521_0101	ENOG4105DA5	(ABC) transporter
D521_0102	ENOG4105E3A	(ABC) transporter
D521_0103	ENOG4105VFK	BolA family
D521_0104	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
D521_0105	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
D521_0106	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
D521_0107	ENOG4105CIH	Imidazole acetol-phosphate transaminase
D521_0108	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
D521_0109	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
D521_0110	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
D521_0111	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
D521_0112	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
D521_0113	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
D521_0114	ENOG4107YU2	histidine triad (hIT) protein
D521_0115	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
D521_0116	ENOG4107Z6S	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
D521_0117	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
D521_0119	ENOG4108Z9W	Outer membrane porin
D521_0120	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
D521_0121	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
D521_0122	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
D521_0123	ENOG4105EIX	cytochrome c1
D521_0124	ENOG4107MKT	Stringent starvation protein a
D521_0125	ENOG4105KB2	stringent starvation protein b
D521_0130	ENOG4105CSH	Transporter
D521_0131	ENOG4105CGY	Dna recombination protein
D521_0133	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
D521_0134	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
D521_0135	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
D521_0137	ENOG4105NFY	transcriptional modulator of maze toxin, mazf
D521_0138	ENOG4106FC9	Protein  of unknown function (DUF3018)
D521_0139	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
D521_0141	ENOG4105T95	Thiol disulfide interChange protein
D521_0142	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
D521_0143	ENOG4105C3G	gtp-binding protein
D521_0146	ENOG4105DK0	Indole-3-glycerol phosphate synthase
D521_0147	ENOG4107QYG	anthranilate phosphoribosyltransferase
D521_0148	ENOG4105DDQ	anthranilate synthase
D521_0149	ENOG4105CRQ	synthase (Component I)
D521_0150	ENOG4105DJV	ribulose-phosphate 3-epimerase
D521_0151	ENOG4105NWN	ApaG protein
D521_0155	ENOG4105CH2	amidohydrolase
D521_0156	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
D521_0157	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
D521_0159	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
D521_0160	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
D521_0162	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
D521_0163	ENOG4105N8N	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
D521_0164	ENOG4105CJN	penicillin-binding protein
D521_0165	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
D521_0166	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
D521_0167	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
D521_0168	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
D521_0169	ENOG4105CNI	cell division protein FtsW
D521_0170	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
D521_0171	ENOG4105DFU	Cell wall formation (By similarity)
D521_0172	ENOG4105CPF	Cell wall formation (By similarity)
D521_0173	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
D521_0174	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
D521_0175	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
D521_0177	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
D521_0179	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
D521_0180	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
D521_0182	ENOG4105M6F	mutator MutT protein
D521_0183	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
D521_0185	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
D521_0187	ENOG4107QHF	type ii secretion system protein e
D521_0188	ENOG4108JU6	CBS domain protein
D521_0190	ENOG4105FE1	phytoene synthase
D521_0192	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
D521_0195	ENOG4105EAH	synthase
D521_0196	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
D521_0197	ENOG4105K46	50S ribosomal protein l27
D521_0198	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D521_0199	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
D521_0201	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
D521_0202	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
D521_0203	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D521_0205	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
D521_0206	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
D521_0207	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
D521_0211	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
D521_0212	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
D521_0213	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
D521_0214	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
D521_0215	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D521_0216	ENOG4105DFU	Cell wall formation (By similarity)
D521_0217	ENOG4105CHR	reductase
D521_0218	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
D521_0220	ENOG4105E2X	shikimate dehydrogenase
D521_0221	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
D521_0222	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
D521_0223	ENOG4107QUT	magnesium and cobalt transport protein CorA
D521_0225	ENOG4108ZAI	phosphatidylglycerophosphatase a
D521_0226	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
D521_0227	ENOG4105C6K	Malic enzyme
D521_0229	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
D521_0230	ENOG4105CV1	Transketolase (EC 2.2.1.1)
D521_0231	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
D521_0232	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
D521_0233	ENOG41090R7	Ferric uptake
D521_0234	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
D521_0235	ENOG4105C8T	Leucyl-tRNA synthetase
D521_0238	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
D521_0239	ENOG4108YXA	Membrane
D521_0240	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
D521_0241	ENOG4105VCQ	rubredoxin
D521_0242	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
D521_0243	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
D521_0244	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
D521_0246	ENOG4108UJU	UPF0301 protein
D521_0247	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
D521_0248	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
D521_0249	ENOG4105CXT	aspartate transcarbamylase
D521_0253	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
D521_0255	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
D521_0256	ENOG4105D16	lipopolysaccharide heptosyltransferase i
D521_0258	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
D521_0260	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
D521_0262	ENOG4107YIM	Involved in the transcription termination process (By similarity)
D521_0263	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
D521_0270	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
D521_0271	ENOG4108R6K	riboflavin synthase, subunit alpha
D521_0272	ENOG4105K4U	addiction module toxin, RelE StbE family
D521_0273	ENOG4105UG9	Antitoxin of the YafO-YafN toxin-antitoxin system
D521_0274	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
D521_0276	ENOG4105KCK	Peptidoglycan-associated lipoprotein
D521_0277	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
D521_0279	ENOG4105M8F	Biopolymer transport protein exbD tolR
D521_0280	ENOG4105E02	MotA TolQ exbB proton channel
D521_0281	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
D521_0282	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
D521_0285	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
D521_0286	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
D521_0287	ENOG4105W49	UPF0434 protein
D521_0288	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
D521_0289	ENOG4105M8F	Biopolymer transport protein exbD tolR
D521_0291	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
D521_0293	ENOG4105D4A	Cell wall formation (By similarity)
D521_0294	ENOG4108VPT	UPF0234 protein
D521_0297	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D521_0300	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
D521_0302	ENOG4105EUJ	GTP cyclohydrolase i
D521_0304	ENOG4105VMH	Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity)
D521_0308	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
D521_0310	ENOG4105C30	Nad-dependent epimerase dehydratase
D521_0314	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
D521_0315	ENOG4105FAW	cDP-glucose 4,6-dehydratase
D521_0316	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
D521_0319	ENOG4105D2T	synthase
D521_0320	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
D521_0321	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
D521_0323	ENOG4105C7K	acetolactate synthase
D521_0332	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
D521_0334	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
D521_0350	ENOG4105CP9	extracellular ligand-binding receptor
D521_0351	ENOG4105C32	Amino acid ABC transporter (Permease)
D521_0352	ENOG4105C0Z	ABC transporter
D521_0353	ENOG4108IV0	ABC, transporter
D521_0357	ENOG41080HT	Transcriptional regulator, arsr family
D521_0366	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
D521_0369	ENOG4105DXI	Major Facilitator superfamily
D521_0370	ENOG4105E9K	Isocitrate dehydrogenase
D521_0372	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
D521_0373	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
D521_0377	ENOG4105EMU	Dehydrogenase
D521_0379	ENOG4105I08	Pseudouridine synthase
D521_0380	ENOG4105KZX	Pterin carbinolamine dehydratase
D521_0389	ENOG41063Z6	transcriptional regulator, lysR family
D521_0390	ENOG4108ZCF	integral membrane protein
D521_0394	ENOG4108YZA	Nitrogen regulatory protein pii
D521_0395	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
D521_0397	ENOG4105CQB	FAD linked oxidase domain protein
D521_0398	ENOG4108JU3	Alkyl hydroperoxide reductase
D521_0403	ENOG4105DFG	type I secretion outer membrane protein
D521_0406	ENOG41080HT	Transcriptional regulator, arsr family
D521_0407	ENOG4105K63	Thioredoxin
D521_0415	ENOG4105BZU	Histidine kinase
D521_0421	ENOG4105BZU	Histidine kinase
D521_0422	ENOG4105WH1	Two component transcriptional regulator luxr family
D521_0424	ENOG4105DQQ	Major facilitator superfamily MFS_1
D521_0425	ENOG4105CRU	nitrate reductase, alpha subunit
D521_0426	ENOG4108IUE	nitrate reductase beta subunit
D521_0427	ENOG4105R3A	Nitrate reductase
D521_0428	ENOG4105D0D	Nitrate reductase 2, gamma subunit
D521_0429	ENOG4107B2H	carbonic anhydrase
D521_0432	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
D521_0434	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
D521_0464	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D521_0465	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
D521_0466	ENOG4105K8N	protein family UPF0079, ATPase
D521_0467	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
D521_0470	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
D521_0472	ENOG4105C5R	Aminotransferase
D521_0473	ENOG4108ZJF	Glcg protein
D521_0474	ENOG4105C1J	atp-dependent rna helicase
D521_0475	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
D521_0478	ENOG4107QRS	glycosyltransferase group 2 family protein
D521_0479	ENOG4106WTF	Glycosyl transferase, family 2
D521_0480	ENOG4105BZ1	(ABC) transporter
D521_0481	ENOG4105C03	ribonuclease
D521_0483	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
D521_0484	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
D521_0485	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
D521_0486	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
D521_0487	ENOG4105C12	Phosphoribosylglycinamide synthetase
D521_0488	ENOG4105CDY	transcriptional regulatory protein
D521_0489	ENOG4107R11	Transcriptional regulator
D521_0492	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
D521_0494	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
D521_0497	ENOG4105CEY	Amp-dependent synthetase and ligase
D521_0498	ENOG4105HF0	Membrane
D521_0501	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
D521_0502	ENOG4105EHG	Permease protein
D521_0503	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
D521_0504	ENOG4105D05	Receptor
D521_0506	ENOG4105CFN	oxalyl-CoA decarboxylase
D521_0508	ENOG4105BZU	Histidine kinase
D521_0509	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
D521_0510	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
D521_0511	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
D521_0515	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
D521_0516	ENOG4105DHP	deoxycytidine triphosphate deaminase
D521_0517	ENOG4105CXN	decarboxylase
D521_0520	ENOG4105CH7	arginosuccinase
D521_0521	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
D521_0522	ENOG41076E6	Uroporphyrinogen-III Synthase
D521_0523	ENOG4105RUM	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
D521_0524	ENOG4105C1J	atp-dependent rna helicase
D521_0525	ENOG4107RGH	Aldehyde dehydrogenase
D521_0526	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
D521_0527	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
D521_0528	ENOG4105CUZ	uba thif-type nad fad binding protein
D521_0529	ENOG4105C85	amino acid
D521_0530	ENOG4105DCF	alanine dehydrogenase
D521_0532	ENOG4105CD8	aminopeptidase N
D521_0533	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D521_0536	ENOG4105BZ1	(ABC) transporter
D521_0544	ENOG4105C01	Dihydroxy-acid dehydratase
D521_0547	ENOG4108YZA	Nitrogen regulatory protein pii
D521_0548	ENOG4105C4K	Nad synthetase
D521_0549	ENOG4105F0N	pyrophosphate phospho-hydrolase
D521_0552	ENOG4105C3M	thioredoxin reductase
D521_0553	ENOG4105CNU	cell division protein FtsK
D521_0554	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
D521_0555	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
D521_0556	ENOG4105C9U	ATP-dependent DNA helicase RecQ
D521_0558	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
D521_0559	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
D521_0560	ENOG4107QKW	extracellular solute-binding protein family 1
D521_0563	ENOG4105Z2P	Protein of unknown function (DUF465)
D521_0564	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
D521_0566	ENOG41086DT	Membrane protein of unknown function
D521_0567	ENOG41069P5	Protein slyX homolog
D521_0569	ENOG4105DEN	Luciferase family
D521_0571	ENOG4108VWS	Yaeq family
D521_0572	ENOG4105DZ0	fad dependent oxidoreductase
D521_0573	ENOG4105D4P	Coproporphyrinogen iii oxidase
D521_0576	ENOG4105C5H	ABC transporter
D521_0577	ENOG4106CJB	Phospholipase Carboxylesterase
D521_0580	ENOG4105CTX	dehydratase
D521_0581	ENOG4105F35	Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity)
D521_0582	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
D521_0584	ENOG4105DG4	malate L-lactate dehydrogenase
D521_0589	ENOG4107S7U	Sulfide dehydrogenase
D521_0591	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
D521_0597	ENOG4108M9J	MaoC like domain protein
D521_0599	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
D521_0601	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
D521_0602	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
D521_0603	ENOG4108JQ5	ABC transporter
D521_0604	ENOG4105K4H	Nlp p60 protein
D521_0606	ENOG4105D78	K07001 NTE family protein
D521_0607	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
D521_0608	ENOG4105FE9	pseudouridine synthase
D521_0609	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
D521_0610	ENOG4105CHV	Transcription elongation factor NusA
D521_0611	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
D521_0612	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
D521_0615	ENOG4105BZM	domain protein
D521_0621	ENOG4105D6J	arsenicaL-resistance protein
D521_0622	ENOG4105CAU	Arsenical resistance protein, ArsH
D521_0624	ENOG4107YZX	Universal stress protein
D521_0626	ENOG4105D3G	Pseudouridine synthase
D521_0627	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
D521_0628	ENOG4105BZU	Histidine kinase
D521_0630	ENOG4105BZU	Histidine kinase
D521_0632	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D521_0633	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
D521_0634	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D521_0646	ENOG4105BZU	Histidine kinase
D521_0647	ENOG4105BZU	Histidine kinase
D521_0648	ENOG4105E6M	Sulphatase-modifying factor protein
D521_0649	ENOG4105BZU	Histidine kinase
D521_0651	ENOG4105DHT	Metal Dependent Phosphohydrolase
D521_0652	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
D521_0655	ENOG4105WH1	Two component transcriptional regulator luxr family
D521_0664	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D521_0665	ENOG4107QUV	Domain protein
D521_0666	ENOG4105X5T	
D521_0668	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
D521_0670	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
D521_0672	ENOG4105VAW	lrga family
D521_0674	ENOG4105C7W	Xanthine dehydrogenase
D521_0682	ENOG4105CUJ	penicillin amidase
D521_0687	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
D521_0689	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D521_0695	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
D521_0697	ENOG4108IYU	L-aspartate oxidase
D521_0699	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
D521_0700	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
D521_0702	ENOG4107QP8	phosphohexose isomerase
D521_0707	ENOG4105VBA	Cytochrome
D521_0710	ENOG4105BZU	Histidine kinase
D521_0711	ENOG4105EUZ	Beta-lactamase domain protein
D521_0712	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
D521_0715	ENOG4105CSA	Coproporphyrinogen iii oxidase
D521_0716	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
D521_0717	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
D521_0718	ENOG4105DSJ	YicC domain protein
D521_0719	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
D521_0720	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
D521_0721	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
D521_0722	ENOG4108RRZ	Transcription elongation factor GreB
D521_0723	ENOG4105CY3	ABC transporter, permease
D521_0724	ENOG4105DHJ	ABC, transporter
D521_0725	ENOG4105DY2	Paraquat-inducible protein b
D521_0728	ENOG4105CV6	ABC transporter, permease
D521_0733	ENOG4105C7K	acetolactate synthase
D521_0734	ENOG4108ZP8	Acetolactate synthase small subunit
D521_0735	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
D521_0736	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
D521_0737	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
D521_0738	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
D521_0740	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
D521_0742	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
D521_0744	ENOG4105CP7	Triose-phosphate isomerase
D521_0746	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D521_0747	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D521_0748	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D521_0749	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D521_0753	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
D521_0754	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D521_0755	ENOG4105DF2	NADH dehydrogenase subunit j
D521_0756	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D521_0758	ENOG4105C8S	subunit m
D521_0759	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D521_0760	ENOG4108YZ4	nudix hydrolase
D521_0762	ENOG4106PMH	Extracellular solute-binding protein family 3
D521_0763	ENOG4105E5Q	amino acid AbC transporter
D521_0764	ENOG4105CDA	abc transporter atp-binding protein
D521_0765	ENOG4105E5Q	amino acid AbC transporter
D521_0766	ENOG4105C26	Dehydrogenase
D521_0767	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
D521_0769	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
D521_0770	ENOG4108JDX	DNA polymerase iii, epsilon subunit
D521_0773	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
D521_0775	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
D521_0776	ENOG4105E9H	Lytic Murein transglycosylase
D521_0777	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D521_0778	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
D521_0779	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
D521_0780	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
D521_0783	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
D521_0784	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D521_0785	ENOG4105EEI	dihydropteroate synthase
D521_0786	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
D521_0787	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
D521_0788	ENOG4105C8U	phosphate abc transporter
D521_0789	ENOG4105E2Z	phosphate ABC transporter (Permease
D521_0790	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
D521_0792	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
D521_0793	ENOG4105BZU	Histidine kinase
D521_0795	ENOG4108302	MgtC SapB transporter
D521_0796	ENOG4107RX3	Mg2 transporter protein cora family protein
D521_0803	ENOG4105C9X	ppx gppa phosphatase
D521_0805	ENOG41080IJ	Diacylglycerol kinase
D521_0806	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
D521_0809	ENOG4105CSR	polyphosphate kinase 2
D521_0813	ENOG4107ENK	receptor
D521_0820	ENOG4105CSR	polyphosphate kinase 2
D521_0822	ENOG4108ISG	Major Facilitator
D521_0825	ENOG4105CS1	NAD(P)H quinone oxidoreductase
D521_0826	ENOG4107S2Z	UPF0761 membrane protein
D521_0828	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
D521_0829	ENOG4105D8G	Major Facilitator superfamily
D521_0830	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
D521_0833	ENOG4105PGM	cation diffusion facilitator family transporter
D521_0834	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
D521_0835	ENOG4105C22	threonyL-tRNA synthetase
D521_0836	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
D521_0837	ENOG4105VJV	50s ribosomal protein L35
D521_0838	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
D521_0840	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
D521_0841	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
D521_0844	ENOG4107M1U	Histone family protein nucleoid-structuring protein H-NS
D521_0846	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
D521_0847	ENOG4105C7S	Dehydrogenase
D521_0848	ENOG4107QN2	dihydrolipoyl dehydrogenase
D521_0849	ENOG4105D6Z	AFG1 family ATPase
D521_0850	ENOG4105DB7	PHP domain protein
D521_0851	ENOG4105C31	Tryptophanyl-tRNA synthetase
D521_0853	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
D521_0854	ENOG4105GJM	(LipO)protein
D521_0856	ENOG4105EZE	Cupin 4 family protein
D521_0857	ENOG4108YZY	peptidylprolyl cis-trans isomerase
D521_0858	ENOG4105D7W	serine acetyltransferase
D521_0859	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
D521_0860	ENOG4105ECY	inositol monophosphatase
D521_0861	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
D521_0864	ENOG4105C8N	cysteinyl-tRNA synthetase
D521_0866	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
D521_0867	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
D521_0868	ENOG4105CFH	Aspartokinase
D521_0869	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
D521_0875	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
D521_0876	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
D521_0877	ENOG4105CEY	Amp-dependent synthetase and ligase
D521_0880	ENOG4105CFP	Peptidase U32
D521_0882	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
D521_0883	ENOG4105CC0	LysR family Transcriptional regulator
D521_0884	ENOG41060W2	glyoxylate carboligase
D521_0885	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
D521_0888	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
D521_0891	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
D521_0895	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
D521_0896	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D521_0897	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D521_0898	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
D521_0899	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
D521_0902	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D521_0904	ENOG4106RE7	Cytochrome
D521_0905	ENOG4105DRR	Transcriptional regulator, GntR family
D521_0907	ENOG4105DJT	lAO AO transport system ATPase
D521_0908	ENOG4107QX3	carboxylase
D521_0909	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
D521_0911	ENOG41072GX	Peptidase M22 Glycoprotease
D521_0912	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
D521_0915	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
D521_0916	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D521_0917	ENOG4105C34	Pseudouridine synthase
D521_0918	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
D521_0919	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
D521_0920	ENOG4105CHR	reductase
D521_0922	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
D521_0923	ENOG4105CHU	acetyl-coa acetyltransferase
D521_0924	ENOG4105EAC	phosphoserine phosphatase
D521_0925	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
D521_0926	ENOG4108JA2	transcriptioN-repair coupling factor
D521_0927	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
D521_0929	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
D521_0930	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
D521_0931	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
D521_0932	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
D521_0934	ENOG4108UJV	acyl-CoA thioesterase i
D521_0935	ENOG4108I0Y	(ABC) transporter
D521_0936	ENOG4108ETH	Formylglycinamide ribotide synthetase
D521_0939	ENOG4107QIJ	Aconitate hydratase 2
D521_0940	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
D521_0941	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
D521_0942	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
D521_0943	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
D521_0944	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
D521_0945	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
D521_0946	ENOG4108K0D	peptidase, M48
D521_0953	ENOG4105F8V	Hydrolase, tatD family
D521_0954	ENOG4107QRG	dna polymerase iii
D521_0955	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
D521_0956	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
D521_0957	ENOG4105HHA	aminodeoxychorismate lyase
D521_0960	ENOG4105CNG	UPF0061 protein
D521_0961	ENOG4105E0X	reductase
D521_0962	ENOG4107835	probably involved in intracellular septation (By similarity)
D521_0965	ENOG4108UYE	Lactoylglutathione lyase
D521_0968	ENOG4105C5H	ABC transporter
D521_0970	ENOG4105C1G	acyl-Coa dehydrogenase
D521_0971	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
D521_0972	ENOG4107S76	domain protein
D521_0979	ENOG4105CGH	5'-nucleotidase
D521_0984	ENOG4105W2Z	cytochrome C, class I
D521_0985	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
D521_0987	ENOG4105E0C	molybdate abc transporter
D521_0988	ENOG4108IJ6	ABC transporter
D521_0989	ENOG4105VMH	Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity)
D521_0991	ENOG4105C28	cystathionine
D521_0992	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
D521_0995	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
D521_0997	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
D521_0998	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
D521_0999	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
D521_1000	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
D521_1002	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
D521_1003	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
D521_1004	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
D521_1006	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
D521_1007	ENOG4105BZN	citrate synthase
D521_1008	ENOG41060IS	Flavinator of succinate dehydrogenase
D521_1009	ENOG4105E33	succinate dehydrogenase
D521_1010	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
D521_1011	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
D521_1012	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
D521_1013	ENOG4105FDP	GntR family transcriptional regulator
D521_1014	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
D521_1017	ENOG4105D1Q	UPF0246 protein
D521_1018	ENOG4105CHM	Aminotransferase
D521_1019	ENOG4105CYM	Glutathione S-transferase
D521_1020	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
D521_1022	ENOG4105D1H	recombination factor protein RarA
D521_1024	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
D521_1025	ENOG4105CRQ	synthase (Component I)
D521_1027	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
D521_1028	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
D521_1029	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
D521_1030	ENOG4107HP6	Transcriptional regulator
D521_1031	ENOG41061WM	D-Alanyl-D-Alanine
D521_1033	ENOG4108WFY	phasin family
D521_1034	ENOG4107QN2	dihydrolipoyl dehydrogenase
D521_1035	ENOG4107QSN	dihydrolipoamide acetyltransferase
D521_1036	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
D521_1037	ENOG4105BZU	Histidine kinase
D521_1038	ENOG4108ZXC	Two component transcriptional regulator, luxr family
D521_1039	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
D521_1040	ENOG4105DGW	oligopeptidase A
D521_1041	ENOG4105CGK	Exodeoxyribonuclease III
D521_1042	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D521_1043	ENOG4105CUX	Signal transduction histidine kinase
D521_1044	ENOG4105C5F	glutamine synthetase
D521_1050	ENOG4105CQ7	ATP-dependent helicase
D521_1051	ENOG4108EKC	n-acetylglutamate synthase
D521_1052	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
D521_1053	ENOG4105E66	phosphoriboisomerase A
D521_1054	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
D521_1055	ENOG4105K63	Thioredoxin
D521_1057	ENOG4105C2N	RNA methyltransferase TrmH family group 3
D521_1058	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
D521_1061	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
D521_1065	ENOG4107QP3	malate synthase g
D521_1066	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
D521_1067	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
D521_1068	ENOG4105EPW	hflc protein
D521_1069	ENOG4107QJR	hflk protein
D521_1070	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
D521_1071	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
D521_1072	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
D521_1075	ENOG4105CUT	histidyl-tRNA synthetase
D521_1076	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
D521_1077	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
D521_1078	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
D521_1079	ENOG4108XRP	Membrane
D521_1080	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
D521_1082	ENOG4108K5P	(LipO)protein
D521_1083	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
D521_1084	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
D521_1091	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
D521_1092	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
D521_1093	ENOG4107QMP	dna polymerase iii subunits gamma and tau
D521_1096	ENOG4107YU2	histidine triad (hIT) protein
D521_1100	ENOG4105UMD	exodeoxyribonuclease X
D521_1101	ENOG4108TEB	UPF0114 protein
D521_1103	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
D521_1104	ENOG4105KT5	UmuD protein
D521_1108	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
D521_1110	ENOG4105K63	Thioredoxin
D521_1111	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
D521_1112	ENOG4105NRA	50s ribosomal protein l31 type b
D521_1114	ENOG4107QI1	Mate efflux family protein
D521_1118	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
D521_1120	ENOG4108M7F	enoyl-CoA hydratase isomerase
D521_1123	ENOG4105W3H	MtN3 and saliva related transmembrane protein
D521_1125	ENOG4105CE1	Ferrous iron transport protein b
D521_1127	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
D521_1130	ENOG4105X1Q	TOBE domain protein
D521_1132	ENOG41082BV	acetyltransferase
D521_1134	ENOG4108T2C	cysteine dioxygenase type I
D521_1135	ENOG4105C1J	atp-dependent rna helicase
D521_1136	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
D521_1142	ENOG4108Z18	K06886 hemoglobin
D521_1143	ENOG4105CBX	hi0933 family
D521_1147	ENOG4105CY0	Metallo-Beta-Lactamase
D521_1148	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
D521_1149	ENOG4106UX7	integral membrane protein
D521_1152	ENOG4105C5R	Aminotransferase
D521_1154	ENOG4105DMF	Dehydrogenase
D521_1158	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
D521_1159	ENOG4105C5Q	Transcriptional regulator
D521_1160	ENOG4108RAC	Rubrerythrin
D521_1161	ENOG4105VCQ	rubredoxin
D521_1162	ENOG4107QZF	nitrite reductase NADPH large subunit
D521_1164	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
D521_1165	ENOG4105DTD	Dehydrogenase
D521_1170	ENOG410630P	Transcriptional regulator
D521_1174	ENOG4105C32	Amino acid ABC transporter (Permease)
D521_1175	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
D521_1176	ENOG4105C0Z	ABC transporter
D521_1177	ENOG4108IV0	ABC, transporter
D521_1178	ENOG4105W39	Membrane
D521_1180	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
D521_1181	ENOG4105X23	Endonuclease Exonuclease phosphatase
D521_1188	ENOG4105QAX	Iron-sulfur
D521_1189	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
D521_1196	ENOG4107QXV	Phosphate transporter
D521_1197	ENOG4107GRR	phosphate transport regulator
D521_1199	ENOG4105C59	p-type ATPase
D521_1205	ENOG4105D6S	protein involved in catabolism of external DNA
D521_1207	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
D521_1208	ENOG4108Z6B	deaminase
D521_1210	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
D521_1214	ENOG4105ED9	Protein of unknown function (DUF455)
D521_1217	ENOG4105D85	methylase
D521_1224	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
D521_1225	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D521_1227	ENOG4108Z1B	Cyclase dehydrase
D521_1228	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
D521_1233	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
D521_1234	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
D521_1236	ENOG4107GFK	fumarate
D521_1237	ENOG4106DSS	Tartrate dehydratase subunit alpha
D521_1239	ENOG4105EJC	lysr family transcriptional regulator
D521_1242	ENOG4105C1G	acyl-Coa dehydrogenase
D521_1244	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
D521_1247	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
D521_1249	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
D521_1250	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
D521_1251	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
D521_1253	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D521_1254	ENOG4105DZP	Membrane-associated zinc metalloprotease
D521_1255	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
D521_1256	ENOG4105KNE	Phosphatidate cytidylyltransferase
D521_1257	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
D521_1258	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
D521_1259	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
D521_1260	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
D521_1261	ENOG4105CE9	30S ribosomal protein S2
D521_1262	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
D521_1263	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
D521_1265	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
D521_1268	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
D521_1269	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
D521_1270	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
D521_1271	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
D521_1273	ENOG4105DFH	Transport of potassium into the cell (By similarity)
D521_1276	ENOG4105C0D	helicase
D521_1289	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D521_1310	ENOG4105VUH	addiction module killer protein
D521_1311	ENOG41067CV	Integrase
D521_1316	ENOG4108EC8	DNA internalization-related competence protein ComEC
D521_1317	ENOG4105EYA	deoxyribonuclease
D521_1318	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
D521_1321	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
D521_1322	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
D521_1323	ENOG4105CRK	lysyL-tRNA synthetase
D521_1327	ENOG4105DP0	ferredoxin-NADP reductase
D521_1329	ENOG4105HMI	Membrane
D521_1330	ENOG4105FDP	GntR family transcriptional regulator
D521_1331	ENOG4105CTX	dehydratase
D521_1332	ENOG4105VP7	SAF domain protein
D521_1333	ENOG4105DG4	malate L-lactate dehydrogenase
D521_1336	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
D521_1342	ENOG4105DUM	transcriptional regulator, lysR family
D521_1345	ENOG4108NST	exported protein
D521_1346	ENOG4108ZIT	Ferredoxin, 2FE-2S
D521_1347	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
D521_1348	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
D521_1349	ENOG4108Z4V	iron-sulfur cluster assembly
D521_1350	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
D521_1351	ENOG4105C3J	Cysteine desulfurase
D521_1352	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
D521_1353	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
D521_1354	ENOG4105CGF	Aromatic amino acid aminotransferase
D521_1356	ENOG4108R3D	Electron transport complex
D521_1357	ENOG4105CSM	endonuclease III
D521_1360	ENOG41067HS	methyltransferase
D521_1361	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
D521_1364	ENOG4108I9X	Isocitrate lyase
D521_1366	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
D521_1368	ENOG4105DKD	Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity)
D521_1379	ENOG4108QDE	fad dependent oxidoreductase
D521_1380	ENOG4108ZAF	Molybdopterin
D521_1382	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
D521_1384	ENOG4105D6E	homoserine dehydrogenase
D521_1385	ENOG4105CHM	Aminotransferase
D521_1387	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
D521_1388	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
D521_1389	ENOG4105CKK	Glycosyl transferase, family 2
D521_1392	ENOG4105F73	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
D521_1393	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D521_1394	ENOG4108IAB	Phoh family
D521_1395	ENOG4105K4H	Nlp p60 protein
D521_1396	ENOG4105D64	Mechanosensitive ion channel
D521_1398	ENOG4105CDU	Replicative dna helicase
D521_1399	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
D521_1400	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
D521_1402	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
D521_1403	ENOG4107RB3	L-asparaginase
D521_1404	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
D521_1410	ENOG4105CMR	udp-glucose 4-epimerase
D521_1413	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
D521_1414	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
D521_1415	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
D521_1416	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
D521_1417	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
D521_1418	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
D521_1419	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
D521_1420	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
D521_1421	ENOG4105C3F	Signal peptidase i
D521_1422	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
D521_1423	ENOG4105C0H	protease
D521_1424	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
D521_1426	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
D521_1427	ENOG4105CHR	reductase
D521_1428	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
D521_1429	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
D521_1430	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
D521_1431	ENOG4105VGS	50s ribosomal protein l32
D521_1432	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
D521_1433	ENOG4108UHJ	MAF-like protein
D521_1436	ENOG4108YZS	Had-superfamily hydrolase, subfamily ia, variant 1
D521_1437	ENOG4105EI2	Pseudouridine synthase
D521_1438	ENOG4105C03	ribonuclease
D521_1439	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D521_1440	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
D521_1441	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
D521_1443	ENOG4105C5I	Dehydrogenase
D521_1444	ENOG4108Z4U	Ferredoxin
D521_1445	ENOG4105CAY	ferredoxin--nadp reductase
D521_1446	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
D521_1448	ENOG4105CH5	extracellular solute-binding protein, family 7
D521_1449	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
D521_1450	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
D521_1451	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
D521_1452	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
D521_1453	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
D521_1455	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
D521_1456	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
D521_1457	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
D521_1458	ENOG4105K5M	30s ribosomal protein S16
D521_1462	ENOG4105CSU	acyl-Coa dehydrogenase
D521_1463	ENOG4105BZJ	Electron transfer flavoprotein
D521_1464	ENOG4105CEY	Amp-dependent synthetase and ligase
D521_1466	ENOG4105CVE	Lytic murein transglycosylase
D521_1467	ENOG4105C6T	cysteine synthase
D521_1472	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
D521_1473	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
D521_1474	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
D521_1475	ENOG4105CFV	Tetratricopeptide repeat protein
D521_1476	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
D521_1477	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
D521_1478	ENOG4105CAT	Cytidine monophosphate kinase
D521_1479	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
D521_1481	ENOG4105CIH	Imidazole acetol-phosphate transaminase
D521_1483	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
D521_1484	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D521_1485	ENOG4105UYK	outer membrane protein a
D521_1486	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
D521_1487	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
D521_1488	ENOG4105C01	Dihydroxy-acid dehydratase
D521_1495	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
D521_1497	ENOG4105C72	UPF0176 protein
D521_1498	ENOG41061CK	Antibiotic biosynthesis monooxygenase
D521_1499	ENOG4105C5I	Dehydrogenase
D521_1503	ENOG4107Z6W	Protein CrcB homolog
D521_1504	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
D521_1507	ENOG4108Z4T	Peptidase M50
D521_1508	ENOG4105T86	cytochrome C
D521_1510	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
D521_1511	ENOG4105C5I	Dehydrogenase
D521_1512	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
D521_1515	ENOG4105CXK	mandelate racemase muconate lactonizing
D521_1516	ENOG4105DR5	peptidase
D521_1519	ENOG4105CHH	sulfate transporter
D521_1521	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
D521_1524	ENOG4105C58	cytochrome c oxidase accessory protein ccog
D521_1528	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
D521_1530	ENOG4105C59	p-type ATPase
D521_1534	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
D521_1535	ENOG4108W0S	formate-dependent nitrite reductase complex
D521_1536	ENOG4105KWW	Biogenesis protein
D521_1537	ENOG4107QX9	Thiol disulfide interChange protein
D521_1538	ENOG4105DA4	cytochrome c-type biogenesis protein
D521_1539	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
D521_1541	ENOG41060IM	Heme exporter protein
D521_1542	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
D521_1543	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
D521_1547	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
D521_1549	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
D521_1557	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
D521_1559	ENOG4105DGU	Histone deacetylase
D521_1561	ENOG4105EYW	Ion transport protein
D521_1569	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
D521_1571	ENOG4105EUJ	GTP cyclohydrolase i
D521_1578	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
D521_1579	ENOG410642W	LysR family Transcriptional regulator
D521_1580	ENOG4105C10	Electron transfer flavoprotein
D521_1581	ENOG4105BZJ	Electron transfer flavoprotein
D521_1597	ENOG4105F9F	transposase
D521_1601	ENOG4105C10	Electron transfer flavoprotein
D521_1602	ENOG4105BZJ	Electron transfer flavoprotein
D521_1603	ENOG4105C1G	acyl-Coa dehydrogenase
D521_1604	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
D521_1615	ENOG4105KIP	Thioesterase
D521_1616	ENOG4105ECQ	AraC Family Transcriptional Regulator
D521_1621	ENOG4107QHE	Choloylglycine hydrolase
D521_1625	ENOG4105DY2	Paraquat-inducible protein b
D521_1626	ENOG4105F1S	paraquat-inducible protein a
D521_1633	ENOG4105BZU	Histidine kinase
D521_1643	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D521_1653	ENOG4105C59	p-type ATPase
D521_1660	ENOG4105UTB	Blue (Type 1) copper domain protein
D521_1670	ENOG4105W1Y	Transcriptional regulator
D521_1673	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
D521_1684	ENOG4105CSH	Transporter
D521_1690	ENOG4105VCC	30S ribosomal protein S21
D521_1691	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D521_1692	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
D521_1693	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
D521_1694	ENOG4105CTB	Polyprenyl synthetase
D521_1695	ENOG41082UU	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
D521_1697	ENOG4105KHC	sulfurtransferase
D521_1699	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
D521_1700	ENOG4105C2M	dna polymerase I
D521_1702	ENOG4105CUV	Homoserine Kinase
D521_1704	ENOG4105C4R	Atp-dependent dna helicase
D521_1705	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
D521_1706	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
D521_1708	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
D521_1709	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
D521_1712	ENOG4105CX6	glutaminyL-tRNA synthetase
D521_1715	ENOG4105C8Y	Acetylornithine aminotransferase
D521_1716	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
D521_1717	ENOG4105W5Q	DNA repair protein (RadC
D521_1718	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
D521_1719	ENOG4105KDC	50s ribosomal protein l28
D521_1720	ENOG4105W0E	50S ribosomal protein L33
D521_1723	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
D521_1724	ENOG4105DTN	riboflavin biosynthesis protein ribF
D521_1725	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
D521_1726	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
D521_1727	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
D521_1728	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
D521_1730	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
D521_1731	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
D521_1732	ENOG4105VEQ	Cold shock protein
D521_1734	ENOG4105NBK	UPF0345 protein
D521_1735	ENOG4105CDH	Citrulline--aspartate ligase
D521_1736	ENOG4105DBV	ornithine carbamoyltransferase
D521_1738	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
D521_1739	ENOG4105CJR	Integral membrane protein (MviN
D521_1741	ENOG4105DQR	SNARE associated Golgi
D521_1742	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
D521_1743	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
D521_1744	ENOG4105C02	permease
D521_1747	ENOG4105DJ0	Poly(A) Polymerase
D521_1750	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
D521_1751	ENOG4105CFG	Acts as a chaperone (By similarity)
D521_1752	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D521_1753	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
D521_1754	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
D521_1755	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
D521_1756	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
D521_1757	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
D521_1760	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
D521_1761	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
D521_1762	ENOG4108WBT	adenosyltransferase
D521_1763	ENOG4105CQB	FAD linked oxidase domain protein
D521_1764	ENOG4105EU8	FAD linked oxidase domain protein
D521_1765	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
D521_1766	ENOG4105DFA	alanine racemase domain protein
D521_1767	ENOG4105II7	pyrroline-5-carboxylate reductase
D521_1768	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
D521_1769	ENOG4105CB5	ATP-dependent DNA helicase recG
D521_1770	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
D521_1771	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
D521_1773	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
D521_1774	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
D521_1775	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
D521_1776	ENOG4107QTF	adenylosuccinate lyase
D521_1777	ENOG4108U78	Glutathione S-transferase
D521_1778	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
D521_1779	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
D521_1780	ENOG4105W8H	transhydrogenase (subunit alpha
D521_1781	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
D521_1784	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
D521_1785	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
D521_1791	ENOG4108IV0	ABC, transporter
D521_1792	ENOG4105C0Z	ABC transporter
D521_1796	ENOG4105DRR	Transcriptional regulator, GntR family
D521_1797	ENOG4105C26	Dehydrogenase
D521_1799	ENOG4108RXX	maleylacetoacetate isomerase
D521_1800	ENOG4105C26	Dehydrogenase
D521_1803	ENOG4108WQH	regulatoR
D521_1804	ENOG4105BZU	Histidine kinase
D521_1806	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D521_1807	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
D521_1808	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
D521_1809	ENOG4105C8V	SAICAR synthetase
D521_1811	ENOG4105CA9	Pyruvate kinase
D521_1812	ENOG4105BZA	Phosphoglycerate kinase
D521_1813	ENOG4105CM2	brancheD-chain amino acid aminotransferase
D521_1815	ENOG4105XA0	heptosyltransferase ii
D521_1819	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D521_1824	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D521_1826	ENOG4108ZCF	integral membrane protein
D521_1827	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
D521_1828	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
D521_1829	ENOG4108004	Modulates RecA activity (By similarity)
D521_1830	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
D521_1832	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D521_1833	ENOG4105BZU	Histidine kinase
D521_1837	ENOG4108RPX	mosc domain containing protein
D521_1838	ENOG4105CSH	Transporter
D521_1838	ENOG4105CSH	Transporter
D521_1839	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
D521_1841	ENOG4105CH5	extracellular solute-binding protein, family 7
D521_1842	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
D521_1843	ENOG4105EN6	Membrane
D521_1844	ENOG4108RXX	maleylacetoacetate isomerase
D521_1846	ENOG4108Z0R	Transferase
D521_1853	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D521_1854	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
D521_1855	ENOG4108JU5	Magnesium and cobalt efflux protein
D521_1856	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
D521_1857	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
D521_1858	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
D521_1859	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
D521_1860	ENOG4105E9Q	Acyl-transferase
D521_1861	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
D521_1862	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
D521_1863	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
D521_1864	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
D521_1865	ENOG4105EHM	Aminoglycoside phosphotransferase
D521_1866	ENOG4108S0S	Nucleotidyl transferase
D521_1867	ENOG4107RAQ	aminopeptidase
D521_1868	ENOG4105D0A	hydroxylase
D521_1869	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
D521_1870	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
D521_1871	ENOG4105DC1	bifunctional purine biosynthesis protein purh
D521_1872	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
D521_1873	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
D521_1874	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
D521_1875	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
D521_1876	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
D521_1877	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
D521_1878	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
D521_1879	ENOG4108UJD	30S ribosomal protein S9
D521_1881	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
D521_1882	ENOG4108UKZ	OsmC family
D521_1883	ENOG4105EKE	dihydroorotase
D521_1885	ENOG4108JJ7	ABC transporter
D521_1886	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
D521_1889	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
D521_1892	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D521_1895	ENOG4105C7B	Threonine dehydratase
D521_1897	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
D521_1900	ENOG4107RDB	Major Facilitator
D521_1901	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
D521_1903	ENOG4105C2X	Arabinose 5-phosphate isomerase
D521_1904	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
D521_1907	ENOG4108IUZ	ABC transporter
D521_1908	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
D521_1909	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
D521_1910	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
D521_1911	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
D521_1913	ENOG4105CEN	a g-specific adenine glycosylase
D521_1914	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
D521_1915	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
D521_1916	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
D521_1917	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
D521_1918	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
D521_1919	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
D521_1920	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
D521_1921	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
D521_1922	ENOG4106H78	methyltransferase
D521_1926	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D521_1927	ENOG4108ZX6	Electron transport protein SCO1 SenC
D521_1928	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
D521_1933	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
D521_1935	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
D521_1938	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
D521_1939	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
D521_1941	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
D521_1942	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
D521_1943	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
D521_1944	ENOG4105VW4	glutaredoxin 3
D521_1946	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
D521_1947	ENOG4105CN1	protease
D521_1948	ENOG4105D06	uba thif-type nad fad binding protein
D521_1949	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
D521_1950	ENOG41080Z8	PHOSPHOCARRIER protein
D521_1952	ENOG4105D7Z	glutathione synthase
D521_1954	ENOG4105BZU	Histidine kinase
D521_1955	ENOG4108YZA	Nitrogen regulatory protein pii
D521_1957	ENOG4105W0Z	cytoplasmic protein
D521_1959	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
D521_1960	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
D521_1961	ENOG4108Z43	UPF0250 protein
D521_1965	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
D521_1966	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
D521_1967	ENOG4107Z67	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
D521_1971	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
D521_1972	ENOG4108IXY	short-chain dehydrogenase reductase
D521_1975	ENOG4105C75	arginyL-tRNA synthetase
D521_1977	ENOG4105C3R	Methionine synthase
D521_1978	ENOG4105C3R	Methionine synthase
D521_1982	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
D521_1985	ENOG4108TGY	Glutathione S-transferase
D521_1986	ENOG4105BZS	acriflavin resistance protein
D521_1987	ENOG410624X	efflux transporter, rnd family, mfp subunit
D521_1989	ENOG4105EUB	pirin domain protein
D521_1993	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
D521_1994	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
D521_1995	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
D521_1997	ENOG410904N	short-chain dehydrogenase reductase
D521_1999	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
D521_2001	ENOG4107SC1	transglycosylase
D521_2002	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
D521_2003	ENOG4105SYT	Methylenetetrahydrofolate reductase
D521_2004	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
D521_2005	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
D521_2008	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
D521_2009	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
D521_2010	ENOG4105CGK	Exodeoxyribonuclease III
D521_2011	ENOG4105EYM	Major Facilitator superfamily
D521_2014	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
D521_2015	ENOG4105CAS	nag kinase
D521_2016	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D521_2017	ENOG4105CKI	cobalamin synthesis protein
D521_2018	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D521_2020	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
D521_2021	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
D521_2023	ENOG4105DFF	Rod shape-determining protein mreb
D521_2026	ENOG4105CJN	penicillin-binding protein
D521_2027	ENOG4105CNI	cell division protein FtsW
D521_2032	ENOG41077A9	carbonic anhydrase
D521_2033	ENOG4105D1S	lipid A biosynthesis
D521_2037	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
D521_2044	ENOG4106PMH	Extracellular solute-binding protein family 3
D521_2046	ENOG41079UR	PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity)
D521_2055	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
D521_2059	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
D521_2064	ENOG4105BZU	Histidine kinase
D521_2066	ENOG4105NXP	Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis (By similarity)
D521_2075	ENOG4105DQ4	alcohol dehydrogenase
D521_2088	ENOG4107QMH	DNA methylase
D521_2094	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
D521_2103	ENOG4105DDY	UPF0142 protein ycaO
D521_2104	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D521_2105	ENOG4105ES5	Histidine kinase
D521_2107	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D521_2108	ENOG4105D0M	Protease HtpX homolog
D521_2109	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
D521_2110	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
D521_2111	ENOG4105C79	DNA protecting protein DprA
D521_2112	ENOG4105C9U	ATP-dependent DNA helicase RecQ
D521_2113	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
D521_2114	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
D521_2115	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
D521_2116	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
D521_2117	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
D521_2118	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
D521_2119	ENOG4105VG0	50S ribosomal protein l34