locus-tag	class	description
D521_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D521_0002	COG0592	DNA-directed DNA polymerase activity
D521_0006	COG0411	ABC transporter
D521_0011	COG0445	tRNA wobble uridine modification
D521_0012	COG0357	Ribosomal RNA small subunit methyltransferase G
D521_0013	COG1192	Involved in chromosome partitioning
D521_0014	COG1475	DNA binding
D521_0016	COG0356	it plays a direct role in the translocation of protons across the membrane
D521_0018	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D521_0019	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D521_0020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D521_0021	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D521_0022	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D521_0023	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D521_0024	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D521_0025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D521_0026	COG0509	glycine decarboxylation via glycine cleavage system
D521_0027	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D521_0031	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D521_0032	COG2823	Periplasmic or secreted lipoprotein
D521_0033	COG4654	Cytochrome c, class I
D521_0037	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D521_0038	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D521_0040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D521_0041	COG0081	regulation of translation
D521_0042	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D521_0043	COG0222	ribosome binding
D521_0044	COG0085	RNA polymerase activity
D521_0045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D521_0047	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D521_0048	COG0049	tRNA binding
D521_0049	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D521_0050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D521_0051	COG0051	transcription antitermination factor activity, RNA binding
D521_0052	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D521_0053	COG0088	Forms part of the polypeptide exit tunnel
D521_0054	COG0089	rRNA binding
D521_0055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D521_0056	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D521_0057	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D521_0058	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D521_0059	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D521_0060	COG0255	Belongs to the universal ribosomal protein uL29 family
D521_0061	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D521_0062	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D521_0063	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D521_0064	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D521_0065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D521_0066	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D521_0067	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D521_0068	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D521_0069	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D521_0070	COG1841	ribosomal large subunit assembly
D521_0071	COG0200	Binds to the 23S rRNA
D521_0072	COG0201	protein transport
D521_0073	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D521_0074	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D521_0075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D521_0076	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D521_0077	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D521_0078	COG0202	RNA polymerase activity
D521_0079	COG0203	ribosomal protein L17
D521_0081	COG4232	protein-disulfide reductase activity
D521_0083	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D521_0085	COG0019	diaminopimelate decarboxylase activity
D521_0086	COG1965	Belongs to the frataxin family
D521_0087	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D521_0093	COG0069	glutamate synthase activity
D521_0093	COG0070	glutamate synthase
D521_0093	COG0067	glutamate synthase
D521_0095	COG1127	ABC transporter
D521_0096	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D521_0097	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D521_0101	COG1131	(ABC) transporter
D521_0102	COG0842	Transport permease protein
D521_0103	COG5007	Belongs to the BolA IbaG family
D521_0104	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D521_0105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D521_0106	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D521_0107	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D521_0108	COG0131	Imidazoleglycerol-phosphate dehydratase
D521_0110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D521_0111	COG0107	imidazoleglycerol-phosphate synthase activity
D521_0112	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D521_0113	COG0140	phosphoribosyl-ATP diphosphatase activity
D521_0114	COG0537	adenosine 5'-monophosphoramidase activity
D521_0115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D521_0116	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D521_0117	COG0805	protein transport
D521_0119	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D521_0120	COG1970	mechanosensitive ion channel activity
D521_0121	COG0723	plastoquinol--plastocyanin reductase activity
D521_0122	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D521_0123	COG2857	Cytochrome c1
D521_0124	COG0625	glutathione transferase activity
D521_0130	COG0477	Major facilitator Superfamily
D521_0132	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D521_0133	COG2890	protein-(glutamine-N5) methyltransferase activity
D521_0134	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D521_0135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D521_0137	COG2337	Toxic component of a toxin-antitoxin (TA) module
D521_0139	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D521_0141	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D521_0142	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D521_0143	COG0012	GTP binding
D521_0146	COG0134	indole-3-glycerol-phosphate synthase activity
D521_0147	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D521_0150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D521_0151	COG2967	ApaG domain
D521_0156	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D521_0157	COG0156	8-amino-7-oxononanoate synthase activity
D521_0159	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D521_0160	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D521_0162	COG0275	rRNA processing
D521_0163	COG3116	cell division
D521_0165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D521_0166	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D521_0167	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D521_0168	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D521_0169	COG0772	Belongs to the SEDS family
D521_0170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D521_0171	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D521_0172	COG1181	Belongs to the D-alanine--D-alanine ligase family
D521_0173	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D521_0176	COG0678	peroxiredoxin activity
D521_0177	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D521_0179	COG0653	protein targeting
D521_0182	COG0494	nUDIX hydrolase
D521_0183	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D521_0185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D521_0187	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D521_0188	COG4536	flavin adenine dinucleotide binding
D521_0190	COG1562	ergosterol biosynthetic process
D521_0192	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D521_0195	COG0142	geranyltranstransferase activity
D521_0196	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D521_0197	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D521_0198	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D521_0199	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D521_0201	COG0494	nUDIX hydrolase
D521_0202	COG0442	prolyl-tRNA aminoacylation
D521_0203	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D521_0205	COG3023	N-Acetylmuramoyl-L-alanine amidase
D521_0206	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D521_0206	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D521_0207	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D521_0211	COG2264	protein methyltransferase activity
D521_0212	COG0439	Biotin carboxylase
D521_0213	COG0511	ligase activity, forming carbon-carbon bonds
D521_0214	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D521_0215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D521_0216	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D521_0217	COG1028	Short-chain dehydrogenase reductase Sdr
D521_0218	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D521_0221	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D521_0222	COG0284	orotidine-5'-phosphate decarboxylase activity
D521_0223	COG0598	Magnesium transport protein CorA
D521_0225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D521_0229	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D521_0231	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D521_0232	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D521_0233	COG0735	belongs to the Fur family
D521_0234	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D521_0235	COG0495	leucyl-tRNA aminoacylation
D521_0238	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D521_0241	COG1773	rubredoxin
D521_0242	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D521_0243	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D521_0244	COG0415	Belongs to the DNA photolyase family
D521_0246	COG1678	Uncharacterized ACR, COG1678
D521_0247	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D521_0248	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D521_0249	COG0540	Belongs to the ATCase OTCase family
D521_0253	COG1091	dTDP-4-dehydrorhamnose reductase activity
D521_0258	COG1968	undecaprenyl-diphosphatase activity
D521_0260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D521_0262	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D521_0263	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D521_0270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D521_0270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D521_0272	COG2026	Addiction module toxin, RelE StbE family
D521_0273	COG2161	toxin-antitoxin pair type II binding
D521_0274	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D521_0277	COG0823	Involved in the tonB-independent uptake of proteins
D521_0281	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D521_0282	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D521_0285	COG0563	adenylate kinase activity
D521_0286	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D521_0287	COG2835	tetraacyldisaccharide 4'-kinase activity
D521_0288	COG1663	tetraacyldisaccharide 4'-kinase activity
D521_0289	COG0848	biopolymer transport protein
D521_0290	COG0811	peptide transport
D521_0291	COG1570	exodeoxyribonuclease VII activity
D521_0293	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D521_0294	COG1666	GTP binding
D521_0297	COG4974	Belongs to the 'phage' integrase family
D521_0302	COG0302	gtp cyclohydrolase
D521_0310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D521_0314	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D521_0319	COG2089	acid synthase
D521_0321	COG1028	Short-chain dehydrogenase reductase Sdr
D521_0323	COG0028	Belongs to the TPP enzyme family
D521_0326	COG0463	Glycosyl transferase, family 2
D521_0330	COG0387	Pfam Sodium calcium exchanger
D521_0334	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D521_0350	COG0683	leucine binding
D521_0351	COG0559	Belongs to the binding-protein-dependent transport system permease family
D521_0352	COG0411	ABC transporter
D521_0357	COG0640	Transcriptional regulator
D521_0366	COG0741	lytic transglycosylase activity
D521_0369	COG2814	Major facilitator Superfamily
D521_0372	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D521_0373	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D521_0377	COG4221	oxidoreductase activity
D521_0379	COG1187	pseudouridine synthase activity
D521_0380	COG2154	pterin-4-alpha-carbinolamine dehydratase
D521_0389	COG0583	DNA-binding transcription factor activity
D521_0390	COG0861	Integral membrane protein TerC family
D521_0394	COG0347	Belongs to the P(II) protein family
D521_0397	COG0277	FAD linked oxidase domain protein
D521_0397	COG0247	lactate metabolic process
D521_0398	COG3634	alkyl hydroperoxide reductase activity
D521_0406	COG0640	Transcriptional regulator
D521_0407	COG3118	belongs to the thioredoxin family
D521_0415	COG4191	Histidine kinase
D521_0421	COG3850	Histidine kinase
D521_0422	COG2197	response regulator
D521_0424	COG2223	nitrite transmembrane transporter activity
D521_0425	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D521_0426	COG1140	nitrate reductase beta subunit
D521_0427	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D521_0428	COG2181	nitrate reductase activity
D521_0429	COG0288	reversible hydration of carbon dioxide
D521_0432	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D521_0434	COG0577	efflux transmembrane transporter activity
D521_0434	COG1136	(ABC) transporter
D521_0464	COG4974	Belongs to the 'phage' integrase family
D521_0465	COG0860	N-Acetylmuramoyl-L-alanine amidase
D521_0466	COG0802	atpase or kinase
D521_0467	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D521_0470	COG0247	lactate metabolic process
D521_0472	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D521_0473	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D521_0474	COG0513	Belongs to the DEAD box helicase family
D521_0475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D521_0478	COG1216	Glycosyl transferase, family 2
D521_0479	COG0463	Glycosyl transferase, family 2
D521_0481	COG1530	ribonuclease E activity
D521_0483	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D521_0484	COG0799	negative regulation of ribosome biogenesis
D521_0485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D521_0486	COG0408	coproporphyrinogen oxidase activity
D521_0487	COG0151	Belongs to the GarS family
D521_0488	COG0217	transcriptional regulatory protein
D521_0489	COG0583	DNA-binding transcription factor activity
D521_0492	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D521_0494	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D521_0497	COG0318	PFAM AMP-dependent synthetase and ligase
D521_0498	COG0730	response to heat
D521_0501	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D521_0502	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D521_0504	COG4771	TonB-dependent receptor
D521_0508	COG4191	Histidine kinase
D521_0509	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D521_0510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D521_0511	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D521_0515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D521_0516	COG0717	Belongs to the dCTP deaminase family
D521_0517	COG1982	Orn Lys Arg decarboxylase major
D521_0520	COG0165	Argininosuccinate lyase
D521_0521	COG0181	hydroxymethylbilane synthase activity
D521_0523	COG3161	chorismate lyase activity
D521_0524	COG0513	Belongs to the DEAD box helicase family
D521_0526	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D521_0527	COG0259	pyridoxamine-phosphate oxidase activity
D521_0528	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D521_0529	COG1113	amino acid transport
D521_0530	COG0686	Belongs to the AlaDH PNT family
D521_0531	COG2119	membrane
D521_0532	COG0308	aminopeptidase N
D521_0533	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D521_0535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D521_0535	COG0189	ligase activity
D521_0536	COG1132	(ABC) transporter
D521_0538	COG3181	Tripartite tricarboxylate transporter family receptor
D521_0544	COG0129	dihydroxy-acid dehydratase activity
D521_0549	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D521_0552	COG0492	ferredoxin-NADP+ reductase activity
D521_0553	COG1674	ftsk spoiiie
D521_0554	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D521_0555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D521_0556	COG0514	ATP-dependent DNA helicase (RecQ)
D521_0558	COG3842	ATPase activity
D521_0559	COG1178	ABC-type Fe3 transport system permease component
D521_0560	COG1840	ABC-type Fe3 transport system, periplasmic component
D521_0563	COG2841	Protein conserved in bacteria
D521_0564	COG2824	Alkylphosphonate utilization operon protein PhnA
D521_0566	COG1950	PFAM Membrane protein of
D521_0569	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D521_0571	COG4681	YaeQ
D521_0572	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D521_0573	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D521_0574	COG3047	cAMP biosynthetic process
D521_0577	COG0400	carboxylic ester hydrolase activity
D521_0580	COG2721	sulfolactate sulfo-lyase activity
D521_0581	COG1250	3-hydroxyacyl-CoA dehydrogenase
D521_0582	COG3386	PFAM SMP-30 Gluconolaconase
D521_0583	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D521_0584	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D521_0586	COG1741	Belongs to the pirin family
D521_0589	COG0446	pyridine nucleotide-disulphide oxidoreductase
D521_0591	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D521_0597	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D521_0600	COG4166	transmembrane transport
D521_0601	COG4174	ABC transporter (Permease)
D521_0602	COG4239	(ABC) transporter, permease
D521_0603	COG4172	Belongs to the ABC transporter superfamily
D521_0604	COG0791	NLP P60 protein
D521_0606	COG1752	Esterase of the alpha-beta hydrolase superfamily
D521_0607	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D521_0608	COG1187	pseudouridine synthase activity
D521_0609	COG0779	Required for maturation of 30S ribosomal subunits
D521_0610	COG2251	uridine kinase activity
D521_0610	COG0195	Participates in both transcription termination and antitermination
D521_0611	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D521_0612	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D521_0615	COG2183	response to ionizing radiation
D521_0621	COG0798	PFAM Bile acid sodium symporter
D521_0622	COG0431	NADPH-dependent FMN reductase
D521_0624	COG0589	response to stress
D521_0626	COG0564	pseudouridine synthase activity
D521_0628	COG3300	MHYT domain
D521_0628	COG5001	Diguanylate cyclase
D521_0633	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D521_0640	COG4964	Belongs to the GSP D family
D521_0646	COG3706	GGDEF domain
D521_0648	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D521_0651	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D521_0654	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D521_0655	COG2197	response regulator
D521_0664	COG3437	response regulator, receiver
D521_0665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D521_0669	COG3181	Tripartite tricarboxylate transporter family receptor
D521_0672	COG1380	Effector of murein hydrolase LrgA
D521_0674	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D521_0678	COG3258	Cytochrome c
D521_0687	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D521_0689	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D521_0695	COG0243	molybdopterin cofactor binding
D521_0697	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D521_0700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D521_0702	COG0166	Belongs to the GPI family
D521_0703	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D521_0707	COG1858	cytochrome C peroxidase
D521_0710	COG2205	protein histidine kinase activity
D521_0710	COG4191	Histidine kinase
D521_0710	COG0745	RESPONSE REGULATOR receiver
D521_0711	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D521_0712	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D521_0713	COG3181	Tripartite tricarboxylate transporter family receptor
D521_0715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D521_0716	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D521_0717	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D521_0718	COG1561	YicC-like family, N-terminal region
D521_0720	COG1758	RNA polymerase activity
D521_0721	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D521_0723	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D521_0724	COG1127	ABC transporter
D521_0725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D521_0725	COG3008	intermembrane lipid transfer
D521_0728	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D521_0733	COG0028	Belongs to the TPP enzyme family
D521_0734	COG0440	acetolactate synthase activity
D521_0735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D521_0736	COG0688	phosphatidylethanolamine metabolic process
D521_0737	COG1183	phosphatidylcholine synthase activity
D521_0738	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D521_0740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D521_0742	COG1185	polyribonucleotide nucleotidyltransferase activity
D521_0744	COG0149	triose-phosphate isomerase activity
D521_0745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D521_0746	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D521_0747	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D521_0748	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D521_0749	COG0649	NAD binding
D521_0753	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D521_0754	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D521_0756	COG0713	ATP synthesis coupled electron transport
D521_0759	COG1007	ATP synthesis coupled electron transport
D521_0760	COG0494	nUDIX hydrolase
D521_0763	COG0765	amino acid transport
D521_0764	COG1126	abc transporter atp-binding protein
D521_0767	COG1902	pentaerythritol trinitrate reductase activity
D521_0769	COG0473	3-isopropylmalate dehydrogenase activity
D521_0770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D521_0773	COG0328	RNA-DNA hybrid ribonuclease activity
D521_0776	COG0741	lytic transglycosylase activity
D521_0776	COG1388	LysM domain
D521_0777	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D521_0778	COG0505	Belongs to the CarA family
D521_0779	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D521_0780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D521_0783	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D521_0784	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D521_0785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D521_0786	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D521_0787	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D521_0788	COG0573	inorganic phosphate transmembrane transporter activity
D521_0789	COG0581	inorganic phosphate transmembrane transporter activity
D521_0790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D521_0792	COG0745	RESPONSE REGULATOR receiver
D521_0795	COG1285	pathogenesis
D521_0803	COG0248	Ppx GppA phosphatase
D521_0806	COG0438	transferase activity, transferring glycosyl groups
D521_0813	COG4771	TonB-dependent receptor
D521_0820	COG2326	polyphosphate kinase activity
D521_0822	COG0477	Major facilitator Superfamily
D521_0826	COG1295	ribonuclease BN
D521_0828	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D521_0829	COG2814	Major facilitator Superfamily
D521_0834	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D521_0835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D521_0836	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D521_0837	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D521_0838	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D521_0841	COG0776	regulation of translation
D521_0844	COG2916	Histone family protein nucleoid-structuring protein H-NS
D521_0846	COG0567	Dehydrogenase, E1 component
D521_0847	COG0508	dehydrogenase complex catalyzes the overall conversion of
D521_0848	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D521_0849	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D521_0850	COG0613	PHP domain protein
D521_0851	COG0180	Tryptophanyl-tRNA synthetase
D521_0853	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D521_0854	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D521_0856	COG2850	peptidyl-arginine hydroxylation
D521_0857	COG1047	Peptidyl-prolyl cis-trans
D521_0858	COG1045	serine acetyltransferase
D521_0861	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D521_0864	COG0215	cysteine-tRNA ligase activity
D521_0866	COG0825	malonyl-CoA metabolic process
D521_0867	COG0037	tRNA processing
D521_0869	COG0154	amidase activity
D521_0875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D521_0877	COG0318	PFAM AMP-dependent synthetase and ligase
D521_0882	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D521_0883	COG0583	DNA-binding transcription factor activity
D521_0884	COG3960	tartronate-semialdehyde synthase activity
D521_0885	COG3622	Belongs to the hyi family
D521_0886	COG0351	phosphomethylpyrimidine kinase
D521_0888	COG2022	thiamine diphosphate biosynthetic process
D521_0891	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D521_0895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D521_0898	COG3608	succinylglutamate desuccinylase aspartoacylase
D521_0898	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D521_0899	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D521_0902	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D521_0905	COG1802	Transcriptional regulator
D521_0907	COG1703	isobutyryl-CoA mutase activity
D521_0908	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D521_0909	COG0439	Biotin carboxylase
D521_0911	COG1214	PFAM Peptidase M22, glycoprotease
D521_0912	COG0456	acetyltransferase
D521_0915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D521_0916	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D521_0917	COG0564	pseudouridine synthase activity
D521_0919	COG3243	poly(R)-hydroxyalkanoic acid synthase
D521_0920	COG1028	Short-chain dehydrogenase reductase Sdr
D521_0922	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D521_0923	COG0183	Belongs to the thiolase family
D521_0924	COG0560	Phosphoserine phosphatase
D521_0925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D521_0926	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D521_0927	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D521_0929	COG0544	peptidyl-prolyl cis-trans isomerase activity
D521_0930	COG0740	serine-type endopeptidase activity
D521_0931	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D521_0932	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D521_0935	COG4181	ATPase activity
D521_0936	COG0047	phosphoribosylformylglycinamidine synthase activity
D521_0936	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D521_0940	COG0504	CTP synthase activity
D521_0941	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D521_0942	COG0148	phosphopyruvate hydratase activity
D521_0943	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D521_0944	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D521_0945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D521_0946	COG0501	Belongs to the peptidase M48B family
D521_0953	COG0084	hydrolase, TatD family'
D521_0954	COG0470	DNA polymerase III
D521_0955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D521_0957	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D521_0960	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D521_0961	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D521_0962	COG2917	probably involved in intracellular septation
D521_0965	COG0346	lactoylglutathione lyase activity
D521_0968	COG0488	(ABC) transporter
D521_0970	COG1960	acyl-CoA dehydrogenase activity
D521_0971	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D521_0972	COG3453	Protein conserved in bacteria
D521_0972	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D521_0979	COG0737	Belongs to the 5'-nucleotidase family
D521_0985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D521_0986	COG0640	Transcriptional regulator
D521_0995	COG0285	dihydrofolate synthase activity
D521_0997	COG0159	tryptophan synthase activity
D521_0998	COG0133	tryptophan synthase activity
D521_0999	COG0135	phosphoribosylanthranilate isomerase activity
D521_1000	COG0101	tRNA pseudouridine synthase activity
D521_1003	COG0473	3-isopropylmalate dehydrogenase activity
D521_1004	COG0066	3-isopropylmalate dehydratase activity
D521_1006	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D521_1007	COG0372	Belongs to the citrate synthase family
D521_1008	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D521_1009	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D521_1010	COG1053	succinate dehydrogenase
D521_1011	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D521_1012	COG2009	succinate dehydrogenase
D521_1014	COG0039	L-malate dehydrogenase activity
D521_1017	COG3022	response to hydroperoxide
D521_1018	COG0436	Aminotransferase
D521_1019	COG0625	glutathione transferase activity
D521_1020	COG1250	3-hydroxyacyl-CoA dehydrogenase
D521_1022	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D521_1024	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D521_1025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D521_1027	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D521_1028	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D521_1029	COG0167	dihydroorotate dehydrogenase activity
D521_1030	COG1414	Transcriptional regulator
D521_1034	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D521_1035	COG0508	dehydrogenase complex catalyzes the overall conversion of
D521_1036	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D521_1038	COG4566	intracellular signal transduction
D521_1039	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D521_1040	COG0339	signal peptide processing
D521_1041	COG0708	Exodeoxyribonuclease III
D521_1043	COG3852	Histidine kinase
D521_1050	COG1643	Atp-dependent helicase
D521_1051	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D521_1051	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D521_1052	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D521_1053	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D521_1054	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D521_1055	COG3118	belongs to the thioredoxin family
D521_1057	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D521_1058	COG0557	exoribonuclease II activity
D521_1065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D521_1066	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D521_1067	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D521_1068	COG0330	HflC and HflK could
D521_1069	COG0330	HflC and HflK could
D521_1070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D521_1071	COG1923	regulation of RNA biosynthetic process
D521_1072	COG1160	GTP binding
D521_1075	COG0124	histidyl-tRNA synthetase
D521_1076	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D521_1077	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D521_1078	COG0105	UTP biosynthetic process
D521_1080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D521_1082	COG4942	peptidase
D521_1082	COG1388	LysM domain
D521_1083	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D521_1084	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D521_1090	COG3077	Addiction module antitoxin, RelB DinJ family
D521_1091	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D521_1092	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D521_1093	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D521_1096	COG0537	adenosine 5'-monophosphoramidase activity
D521_1100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D521_1103	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D521_1104	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D521_1108	COG1074	ATP-dependent DNA helicase activity
D521_1111	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D521_1112	COG0254	rRNA binding
D521_1114	COG0534	Mate efflux family protein
D521_1118	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D521_1120	COG1024	Enoyl-CoA hydratase
D521_1125	COG1918	ferrous iron import across plasma membrane
D521_1125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D521_1127	COG1910	domain protein
D521_1130	COG3585	molybdate ion transport
D521_1132	COG2153	protein acetylation
D521_1135	COG0513	Belongs to the DEAD box helicase family
D521_1142	COG2346	COG2346, Truncated hemoglobins
D521_1143	COG2081	HI0933 family
D521_1147	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D521_1148	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D521_1148	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D521_1149	COG0697	spore germination
D521_1152	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D521_1154	COG1304	FMN binding
D521_1158	COG1902	pentaerythritol trinitrate reductase activity
D521_1159	COG0583	DNA-binding transcription factor activity
D521_1160	COG1592	Rubrerythrin
D521_1164	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D521_1165	COG1028	Short-chain dehydrogenase reductase Sdr
D521_1176	COG0411	ABC transporter
D521_1178	COG1238	metal cluster binding
D521_1180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D521_1181	COG3568	Endonuclease Exonuclease Phosphatase
D521_1188	COG0437	4 iron, 4 sulfur cluster binding
D521_1189	COG3383	formate dehydrogenase (NAD+) activity
D521_1189	COG0243	molybdopterin cofactor binding
D521_1195	COG0489	protein tyrosine kinase activity
D521_1196	COG0306	phosphate transporter
D521_1197	COG1392	Phosphate transport regulator
D521_1199	COG2217	Heavy metal translocating P-type atpase
D521_1205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D521_1207	COG1619	proteins homologs of microcin C7 resistance protein MccF
D521_1208	COG0590	tRNA wobble adenosine to inosine editing
D521_1210	COG0602	queuosine metabolic process
D521_1214	COG2833	Protein of unknown function (DUF455)
D521_1217	COG1002	Type II restriction enzyme, methylase subunits
D521_1224	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D521_1224	COG0519	Catalyzes the synthesis of GMP from XMP
D521_1227	COG2867	negative regulation of translational initiation
D521_1228	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D521_1229	COG2308	Evidence 4 Homologs of previously reported genes of
D521_1236	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D521_1237	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D521_1239	COG0583	DNA-binding transcription factor activity
D521_1242	COG1960	acyl-CoA dehydrogenase activity
D521_1244	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D521_1246	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D521_1247	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D521_1249	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D521_1250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D521_1251	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D521_1254	COG0750	zinc metalloprotease
D521_1256	COG0575	Belongs to the CDS family
D521_1257	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D521_1258	COG0233	cytoplasmic translational termination
D521_1260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D521_1261	COG0052	Belongs to the universal ribosomal protein uS2 family
D521_1262	COG0024	Methionine aminopeptidase
D521_1265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D521_1268	COG2171	N-acyltransferase activity
D521_1269	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D521_1270	COG2890	protein-(glutamine-N5) methyltransferase activity
D521_1276	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D521_1278	COG2304	oxidoreductase activity
D521_1289	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D521_1310	COG3657	addiction module killer protein
D521_1311	COG0582	viral genome integration into host DNA
D521_1317	COG0084	hydrolase, TatD family'
D521_1321	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D521_1322	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D521_1323	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D521_1329	COG2855	membrane
D521_1330	COG2188	Transcriptional regulator
D521_1331	COG2721	sulfolactate sulfo-lyase activity
D521_1332	COG2721	sulfolactate sulfo-lyase activity
D521_1333	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D521_1334	COG3181	Tripartite tricarboxylate transporter family receptor
D521_1336	COG1053	succinate dehydrogenase
D521_1345	COG3064	Membrane
D521_1347	COG0443	Heat shock 70 kDa protein
D521_1348	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D521_1349	COG0316	Belongs to the HesB IscA family
D521_1350	COG0822	iron-sulfur transferase activity
D521_1351	COG1104	cysteine desulfurase activity
D521_1356	COG2878	Part of a membrane complex involved in electron transport
D521_1357	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D521_1360	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D521_1361	COG0709	Synthesizes selenophosphate from selenide and ATP
D521_1366	COG0542	response to heat
D521_1368	COG0322	excinuclease ABC activity
D521_1379	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
D521_1380	COG0314	molybdopterin synthase activity
D521_1382	COG0303	'Molybdopterin
D521_1385	COG0436	Aminotransferase
D521_1387	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D521_1388	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D521_1392	COG0726	polysaccharide deacetylase
D521_1393	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D521_1394	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D521_1395	COG0791	NLP P60 protein
D521_1396	COG0668	transmembrane transport
D521_1398	COG0305	Participates in initiation and elongation during chromosome replication
D521_1399	COG0359	binds to the 23S rRNA
D521_1400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D521_1402	COG0360	Binds together with S18 to 16S ribosomal RNA
D521_1403	COG0252	asparaginase activity
D521_1404	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D521_1410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D521_1413	COG0322	excinuclease ABC activity
D521_1414	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D521_1415	COG1472	Belongs to the glycosyl hydrolase 3 family
D521_1416	COG0736	holo-[acyl-carrier-protein] synthase activity
D521_1417	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D521_1418	COG1381	Involved in DNA repair and RecF pathway recombination
D521_1419	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D521_1420	COG0571	ribonuclease III activity
D521_1421	COG0681	Belongs to the peptidase S26 family
D521_1422	COG0481	GTPase activity
D521_1423	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D521_1424	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D521_1426	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D521_1427	COG1028	Short-chain dehydrogenase reductase Sdr
D521_1429	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D521_1430	COG0416	fatty acid biosynthetic process
D521_1431	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D521_1432	COG1399	metal-binding, possibly nucleic acid-binding protein
D521_1433	COG0424	maF-like protein
D521_1434	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D521_1436	COG0546	phosphoglycolate phosphatase activity
D521_1438	COG1530	ribonuclease E activity
D521_1439	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D521_1440	COG0746	molybdenum cofactor guanylyltransferase activity
D521_1441	COG0303	'Molybdopterin
D521_1444	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D521_1445	COG0492	ferredoxin-NADP+ reductase activity
D521_1446	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D521_1448	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D521_1449	COG0312	modulator of DNA gyrase
D521_1450	COG0521	Mo-molybdopterin cofactor biosynthetic process
D521_1451	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D521_1452	COG0501	Belongs to the peptidase M48B family
D521_1453	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D521_1455	COG0335	large ribosomal subunit rRNA binding
D521_1456	COG0336	Belongs to the RNA methyltransferase TrmD family
D521_1457	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D521_1458	COG0228	four-way junction DNA binding
D521_1462	COG1960	acyl-CoA dehydrogenase activity
D521_1464	COG0318	PFAM AMP-dependent synthetase and ligase
D521_1465	COG0123	including yeast histone deacetylase and acetoin utilization protein
D521_1466	COG2951	lytic endotransglycosylase activity
D521_1472	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D521_1473	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D521_1475	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D521_1476	COG0776	regulation of translation
D521_1478	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D521_1479	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D521_1480	COG0287	Prephenate dehydrogenase
D521_1483	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D521_1486	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D521_1488	COG0129	dihydroxy-acid dehydratase activity
D521_1489	COG3181	Tripartite tricarboxylate transporter family receptor
D521_1495	COG2264	protein methyltransferase activity
D521_1498	COG2329	Antibiotic biosynthesis monooxygenase
D521_1499	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D521_1503	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D521_1504	COG3384	dioxygenase
D521_1507	COG1994	Peptidase M50
D521_1508	COG3909	cytochrome
D521_1510	COG1250	3-hydroxyacyl-CoA dehydrogenase
D521_1511	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D521_1512	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D521_1515	COG4948	Mandelate Racemase Muconate Lactonizing
D521_1516	COG0739	heme binding
D521_1519	COG0659	secondary active sulfate transmembrane transporter activity
D521_1521	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D521_1524	COG0348	domain, Protein
D521_1528	COG3278	Belongs to the heme-copper respiratory oxidase family
D521_1530	COG2217	Heavy metal translocating P-type atpase
D521_1534	COG1028	Short-chain dehydrogenase reductase Sdr
D521_1535	COG4235	cytochrome complex assembly
D521_1537	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D521_1539	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D521_1542	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D521_1543	COG4133	protoheme IX ABC transporter activity
D521_1549	COG3046	protein related to deoxyribodipyrimidine photolyase
D521_1557	COG0415	Belongs to the DNA photolyase family
D521_1559	COG0123	including yeast histone deacetylase and acetoin utilization protein
D521_1561	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D521_1566	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D521_1567	COG0778	Nitroreductase
D521_1569	COG0415	Belongs to the DNA photolyase family
D521_1570	COG0386	Belongs to the glutathione peroxidase family
D521_1571	COG0302	gtp cyclohydrolase
D521_1578	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D521_1579	COG0583	DNA-binding transcription factor activity
D521_1597	COG2826	transposase and inactivated derivatives, IS30 family
D521_1603	COG1960	acyl-CoA dehydrogenase activity
D521_1604	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D521_1621	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D521_1625	COG3008	intermembrane lipid transfer
D521_1626	COG2995	paraquat-inducible protein a
D521_1633	COG2205	protein histidine kinase activity
D521_1643	COG4974	Belongs to the 'phage' integrase family
D521_1653	COG2217	Heavy metal translocating P-type atpase
D521_1660	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D521_1670	COG0789	Transcriptional regulator
D521_1684	COG0477	Major facilitator Superfamily
D521_1686	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D521_1690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D521_1691	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D521_1692	COG1469	GTP cyclohydrolase I activity
D521_1693	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D521_1694	COG0142	geranyltranstransferase activity
D521_1695	COG1722	exodeoxyribonuclease VII activity
D521_1699	COG0412	Dienelactone hydrolase
D521_1700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D521_1700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D521_1702	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D521_1704	COG0210	DNA helicase
D521_1705	COG0525	valine-tRNA ligase activity
D521_1706	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D521_1708	COG0425	Belongs to the sulfur carrier protein TusA family
D521_1709	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D521_1712	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D521_1715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D521_1716	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D521_1717	COG2003	Belongs to the UPF0758 family
D521_1718	COG1047	Peptidyl-prolyl cis-trans
D521_1719	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D521_1720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D521_1722	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D521_1722	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D521_1723	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D521_1724	COG0196	riboflavin kinase activity
D521_1725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D521_1726	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D521_1727	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D521_1728	COG0756	dUTP diphosphatase activity
D521_1730	COG0542	response to heat
D521_1731	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D521_1732	COG1278	Cold shock
D521_1734	COG3123	guanosine phosphorylase activity
D521_1735	COG0137	argininosuccinate synthase activity
D521_1736	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D521_1738	COG0268	Binds directly to 16S ribosomal RNA
D521_1739	COG0728	peptidoglycan biosynthetic process
D521_1741	COG0586	Pfam SNARE associated Golgi protein
D521_1742	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D521_1743	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D521_1744	COG0628	permease
D521_1747	COG0617	tRNA 3'-terminal CCA addition
D521_1748	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D521_1750	COG0484	heat shock protein binding
D521_1751	COG0443	Heat shock 70 kDa protein
D521_1752	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D521_1753	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D521_1754	COG1420	regulation of RNA biosynthetic process
D521_1756	COG0497	DNA recombination
D521_1757	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D521_1759	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D521_1760	COG0312	modulator of DNA gyrase
D521_1761	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D521_1762	COG2096	Adenosyltransferase
D521_1763	COG0277	FAD linked oxidase domain protein
D521_1764	COG0277	FAD linked oxidase domain protein
D521_1765	COG0247	lactate metabolic process
D521_1766	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D521_1768	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D521_1769	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D521_1770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D521_1773	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D521_1777	COG0625	glutathione transferase activity
D521_1778	COG0482	sulfurtransferase activity
D521_1779	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D521_1780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D521_1781	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D521_1784	COG0459	protein refolding
D521_1785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D521_1788	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D521_1791	COG0410	ABC transporter
D521_1796	COG1802	Transcriptional regulator
D521_1799	COG0625	glutathione transferase activity
D521_1803	COG2197	response regulator
D521_1804	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D521_1804	COG2205	protein histidine kinase activity
D521_1806	COG0009	L-threonylcarbamoyladenylate synthase
D521_1807	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D521_1808	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D521_1809	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D521_1811	COG0469	pyruvate kinase activity
D521_1812	COG0126	phosphoglycerate kinase activity
D521_1819	COG0315	cyclic pyranopterin monophosphate synthase activity
D521_1824	COG0315	cyclic pyranopterin monophosphate synthase activity
D521_1826	COG0861	Integral membrane protein TerC family
D521_1827	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D521_1828	COG0045	succinate-CoA ligase (ADP-forming) activity
D521_1829	COG2137	regulation of response to DNA damage stimulus
D521_1833	COG3706	GGDEF domain
D521_1837	COG2258	MOSC domain
D521_1838	COG0477	Major facilitator Superfamily
D521_1838	COG0477	Major facilitator Superfamily
D521_1839	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D521_1841	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D521_1844	COG0625	glutathione transferase activity
D521_1847	COG0004	ammonium transporteR
D521_1853	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D521_1854	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D521_1855	COG4535	Mg2 and Co2 transporter CorC
D521_1856	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D521_1857	COG0752	glycyl-tRNA synthetase alpha subunit
D521_1858	COG0751	glycine-tRNA ligase activity
D521_1859	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D521_1860	COG0204	Acyl-transferase
D521_1861	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D521_1862	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D521_1863	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D521_1864	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D521_1866	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D521_1867	COG0006	proline dipeptidase activity
D521_1868	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D521_1870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D521_1871	COG0138	bifunctional purine biosynthesis protein purh
D521_1872	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D521_1873	COG0632	four-way junction helicase activity
D521_1874	COG2255	four-way junction helicase activity
D521_1876	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D521_1877	COG0316	Belongs to the HesB IscA family
D521_1878	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D521_1879	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D521_1881	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D521_1882	COG1765	OsmC-like protein
D521_1885	COG5265	(ABC) transporter
D521_1886	COG1051	belongs to the nudix hydrolase family
D521_1889	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D521_1892	COG2226	methyltransferase
D521_1895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D521_1897	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D521_1897	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D521_1899	COG0629	single-stranded DNA binding
D521_1900	COG2814	Major facilitator Superfamily
D521_1904	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D521_1907	COG1137	ATPase activity
D521_1908	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D521_1910	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D521_1911	COG1660	Displays ATPase and GTPase activities
D521_1913	COG1194	a g-specific adenine glycosylase
D521_1914	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D521_1916	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D521_1917	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D521_1918	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D521_1919	COG0193	aminoacyl-tRNA hydrolase activity
D521_1920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D521_1921	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D521_1922	COG0742	ribosomal rna small subunit methyltransferase
D521_1923	COG0612	Peptidase, M16
D521_1924	COG0612	Peptidase, M16
D521_1927	COG1999	signal sequence binding
D521_1928	COG0109	protoheme IX farnesyltransferase activity
D521_1935	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D521_1937	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D521_1939	COG2226	methyltransferase
D521_1941	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D521_1942	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D521_1943	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D521_1946	COG0588	phosphoglycerate mutase activity
D521_1947	COG0793	Belongs to the peptidase S41A family
D521_1949	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D521_1950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D521_1952	COG0189	ligase activity
D521_1954	COG0004	ammonium transporteR
D521_1957	COG2960	long-chain fatty acid transporting porin activity
D521_1959	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D521_1960	COG0321	lipoyl(octanoyl) transferase activity
D521_1961	COG2921	Belongs to the UPF0250 family
D521_1965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D521_1965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D521_1966	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D521_1967	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D521_1968	COG0386	Belongs to the glutathione peroxidase family
D521_1971	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D521_1972	COG0300	oxidoreductase activity
D521_1973	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D521_1975	COG0018	arginyl-trna synthetase
D521_1977	COG1410	methionine synthase
D521_1977	COG0646	methionine synthase
D521_1982	COG0604	alcohol dehydrogenase
D521_1984	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D521_1985	COG0625	glutathione transferase activity
D521_1986	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D521_1987	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D521_1993	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D521_1994	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D521_1995	COG0037	tRNA processing
D521_1997	COG1028	Short-chain dehydrogenase reductase Sdr
D521_1999	COG0617	tRNA 3'-terminal CCA addition
D521_2001	COG0741	lytic transglycosylase activity
D521_2002	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D521_2004	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D521_2005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D521_2008	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D521_2009	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D521_2010	COG0708	Exodeoxyribonuclease III
D521_2011	COG2211	Major facilitator Superfamily
D521_2015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D521_2016	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D521_2017	COG0523	cobalamin synthesis protein
D521_2018	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D521_2020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D521_2021	COG0154	amidase activity
D521_2023	COG1077	Cell shape determining protein MreB Mrl
D521_2026	COG0768	penicillin binding
D521_2027	COG0772	Belongs to the SEDS family
D521_2032	COG0288	reversible hydration of carbon dioxide
D521_2033	COG1560	Kdo2-lipid A biosynthetic process
D521_2036	COG1187	pseudouridine synthase activity
D521_2037	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D521_2053	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D521_2055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D521_2059	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D521_2064	COG4191	Histidine kinase
D521_2066	COG2010	Cytochrome c
D521_2075	COG1064	alcohol dehydrogenase
D521_2088	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D521_2094	COG1959	2 iron, 2 sulfur cluster binding
D521_2103	COG1944	ATP diphosphatase activity
D521_2104	COG2204	response regulator
D521_2105	COG5000	phosphorelay sensor kinase activity
D521_2107	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D521_2107	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D521_2108	COG0501	Belongs to the peptidase M48B family
D521_2109	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D521_2110	COG0242	peptide deformylase activity
D521_2111	COG0758	DNA mediated transformation
D521_2113	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D521_2113	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D521_2114	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D521_2115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D521_2116	COG0706	membrane insertase activity
D521_2117	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D521_2118	COG0594	ribonuclease P activity
D521_2119	COG0230	Belongs to the bacterial ribosomal protein bL34 family