locus-tag	class	description
P147_WWE3C00001G0006	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P147_WWE3C00001G0007	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P147_WWE3C00001G0008	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
P147_WWE3C00001G0008	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P147_WWE3C00001G0009	COG0017	Asparaginyl-tRNA synthetase
P147_WWE3C00001G0010	COG1686	Belongs to the peptidase S11 family
P147_WWE3C00001G0012	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P147_WWE3C00001G0013	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
P147_WWE3C00001G0015	COG1418	mRNA catabolic process
P147_WWE3C00001G0017	COG1692	metallophosphoesterase
P147_WWE3C00001G0020	COG0484	heat shock protein binding
P147_WWE3C00001G0021	COG0195	Participates in both transcription termination and antitermination
P147_WWE3C00001G0022	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
P147_WWE3C00001G0024	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
P147_WWE3C00001G0025	COG1185	polyribonucleotide nucleotidyltransferase activity
P147_WWE3C00001G0027	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P147_WWE3C00001G0028	COG1573	uracil-dna glycosylase
P147_WWE3C00001G0029	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
P147_WWE3C00001G0030	COG1674	ftsk spoiiie
P147_WWE3C00001G0032	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P147_WWE3C00001G0033	COG0542	response to heat
P147_WWE3C00001G0036	COG2003	Belongs to the UPF0758 family
P147_WWE3C00001G0038	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P147_WWE3C00001G0039	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P147_WWE3C00001G0040	COG0203	ribosomal protein L17
P147_WWE3C00001G0041	COG0202	RNA polymerase activity
P147_WWE3C00001G0042	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P147_WWE3C00001G0043	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P147_WWE3C00001G0044	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P147_WWE3C00001G0045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
P147_WWE3C00001G0046	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
P147_WWE3C00001G0048	COG1968	undecaprenyl-diphosphatase activity
P147_WWE3C00001G0049	COG0653	protein targeting
P147_WWE3C00001G0052	COG0681	Belongs to the peptidase S26 family
P147_WWE3C00001G0053	COG0085	RNA polymerase activity
P147_WWE3C00001G0055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P147_WWE3C00001G0056	COG0049	tRNA binding
P147_WWE3C00001G0057	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P147_WWE3C00001G0059	COG0051	transcription antitermination factor activity, RNA binding
P147_WWE3C00001G0060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
P147_WWE3C00001G0061	COG0088	Forms part of the polypeptide exit tunnel
P147_WWE3C00001G0063	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
P147_WWE3C00001G0064	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P147_WWE3C00001G0065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P147_WWE3C00001G0066	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P147_WWE3C00001G0067	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P147_WWE3C00001G0068	COG0255	Belongs to the universal ribosomal protein uL29 family
P147_WWE3C00001G0069	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
P147_WWE3C00001G0072	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P147_WWE3C00001G0073	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P147_WWE3C00001G0074	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
P147_WWE3C00001G0075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P147_WWE3C00001G0080	COG0563	adenylate kinase activity
P147_WWE3C00001G0084	COG0463	Glycosyl transferase, family 2
P147_WWE3C00001G0085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P147_WWE3C00001G0090	COG1216	Glycosyl transferase, family 2
P147_WWE3C00001G0098	COG1215	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0108	COG1215	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0110	COG0438	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0116	COG2226	methyltransferase
P147_WWE3C00001G0120	COG0438	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0122	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
P147_WWE3C00001G0125	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
P147_WWE3C00001G0126	COG1088	dTDP-glucose 4,6-dehydratase activity
P147_WWE3C00001G0127	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
P147_WWE3C00001G0128	COG1215	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0129	COG0438	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0131	COG0438	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0132	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
P147_WWE3C00001G0135	COG0423	glycine-tRNA ligase activity
P147_WWE3C00001G0136	COG2001	Belongs to the MraZ family
P147_WWE3C00001G0137	COG0275	rRNA processing
P147_WWE3C00001G0139	COG0768	penicillin binding
P147_WWE3C00001G0140	COG0792	nuclease activity
P147_WWE3C00001G0143	COG2205	protein histidine kinase activity
P147_WWE3C00001G0145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P147_WWE3C00001G0145	COG0574	Belongs to the PEP-utilizing enzyme family
P147_WWE3C00001G0146	COG0148	phosphopyruvate hydratase activity
P147_WWE3C00001G0147	COG0588	phosphoglycerate mutase activity
P147_WWE3C00001G0148	COG0586	Pfam SNARE associated Golgi protein
P147_WWE3C00001G0149	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P147_WWE3C00001G0151	COG0556	nucleotide-excision repair
P147_WWE3C00001G0153	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P147_WWE3C00001G0155	COG1305	Transglutaminase-like
P147_WWE3C00001G0156	COG0322	excinuclease ABC activity
P147_WWE3C00001G0159	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P147_WWE3C00001G0160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P147_WWE3C00001G0161	COG0772	Belongs to the SEDS family
P147_WWE3C00001G0162	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P147_WWE3C00001G0165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
P147_WWE3C00001G0167	COG2096	Adenosyltransferase
P147_WWE3C00001G0169	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
P147_WWE3C00001G0171	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P147_WWE3C00001G0172	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P147_WWE3C00001G0173	COG0681	Belongs to the peptidase S26 family
P147_WWE3C00001G0176	COG3858	chitin binding
P147_WWE3C00001G0176	COG1388	LysM domain
P147_WWE3C00001G0195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P147_WWE3C00001G0200	COG1652	LysM domain
P147_WWE3C00001G0203	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
P147_WWE3C00001G0203	COG1796	DNA polymerase
P147_WWE3C00001G0204	COG1704	LemA family
P147_WWE3C00001G0206	COG0501	Belongs to the peptidase M48B family
P147_WWE3C00001G0207	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P147_WWE3C00001G0208	COG0154	amidase activity
P147_WWE3C00001G0210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P147_WWE3C00001G0214	COG0542	response to heat
P147_WWE3C00001G0215	COG0335	large ribosomal subunit rRNA binding
P147_WWE3C00001G0221	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P147_WWE3C00001G0222	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
P147_WWE3C00001G0224	COG0612	Peptidase, M16
P147_WWE3C00001G0232	COG0740	serine-type endopeptidase activity
P147_WWE3C00001G0245	COG0741	lytic transglycosylase activity
P147_WWE3C00001G0245	COG1196	nuclear chromosome segregation
P147_WWE3C00001G0245	COG0739	heme binding
P147_WWE3C00001G0247	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
P147_WWE3C00001G0253	COG0747	negative chemotaxis
P147_WWE3C00001G0257	COG2226	methyltransferase
P147_WWE3C00001G0259	COG1278	Cold shock
P147_WWE3C00001G0261	COG0513	Belongs to the DEAD box helicase family
P147_WWE3C00001G0264	COG4733	cellulase activity
P147_WWE3C00001G0264	COG5297	Belongs to the glycosyl hydrolase family 6
P147_WWE3C00001G0272	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P147_WWE3C00001G0274	COG0024	Methionine aminopeptidase
P147_WWE3C00001G0276	COG0495	leucyl-tRNA aminoacylation
P147_WWE3C00001G0277	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P147_WWE3C00001G0278	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P147_WWE3C00001G0279	COG0343	queuine tRNA-ribosyltransferase activity
P147_WWE3C00001G0280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
P147_WWE3C00001G0281	COG0210	DNA helicase
P147_WWE3C00001G0284	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
P147_WWE3C00001G0286	COG1136	(ABC) transporter
P147_WWE3C00001G0287	COG0577	efflux transmembrane transporter activity
P147_WWE3C00001G0290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P147_WWE3C00001G0301	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
P147_WWE3C00001G0322	COG1028	Short-chain dehydrogenase reductase Sdr
P147_WWE3C00001G0331	COG3259	Nickel-dependent hydrogenase
P147_WWE3C00001G0335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
P147_WWE3C00001G0337	COG2217	Heavy metal translocating P-type atpase
P147_WWE3C00001G0340	COG2217	Heavy metal translocating P-type atpase
P147_WWE3C00001G0357	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
P147_WWE3C00001G0358	COG1525	nuclease
P147_WWE3C00001G0361	COG2723	6-phospho-beta-galactosidase activity
P147_WWE3C00001G0363	COG1940	carbohydrate kinase activity
P147_WWE3C00001G0367	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P147_WWE3C00001G0372	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
P147_WWE3C00001G0385	COG3952	Lipid A Biosynthesis
P147_WWE3C00001G0385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P147_WWE3C00001G0391	COG0537	adenosine 5'-monophosphoramidase activity
P147_WWE3C00001G0395	COG0717	Belongs to the dCTP deaminase family
P147_WWE3C00001G0404	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P147_WWE3C00001G0405	COG1187	pseudouridine synthase activity
P147_WWE3C00001G0407	COG0577	efflux transmembrane transporter activity
P147_WWE3C00001G0408	COG0009	L-threonylcarbamoyladenylate synthase
P147_WWE3C00001G0425	COG0484	heat shock protein binding
P147_WWE3C00001G0427	COG0740	serine-type endopeptidase activity
P147_WWE3C00001G0431	COG0662	Cupin 2, conserved barrel domain protein
P147_WWE3C00001G0434	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
P147_WWE3C00001G0435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P147_WWE3C00001G0437	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P147_WWE3C00001G0439	COG0072	phenylalanine-tRNA ligase activity
P147_WWE3C00001G0440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
P147_WWE3C00001G0441	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P147_WWE3C00001G0443	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
P147_WWE3C00001G0446	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P147_WWE3C00001G0447	COG0742	ribosomal rna small subunit methyltransferase
P147_WWE3C00001G0449	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P147_WWE3C00001G0450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P147_WWE3C00001G0452	COG0228	four-way junction DNA binding
P147_WWE3C00001G0453	COG1837	Belongs to the UPF0109 family
P147_WWE3C00001G0463	COG2165	general secretion pathway protein
P147_WWE3C00001G0464	COG4968	Prepilin-type N-terminal cleavage methylation domain
P147_WWE3C00001G0470	COG0745	RESPONSE REGULATOR receiver
P147_WWE3C00001G0471	COG5002	protein histidine kinase activity
P147_WWE3C00001G0472	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P147_WWE3C00001G0474	COG1459	type II secretion system
P147_WWE3C00001G0476	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P147_WWE3C00001G0477	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P147_WWE3C00001G0478	COG0187	DNA topoisomerase II activity
P147_WWE3C00001G0480	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
P147_WWE3C00001G0481	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P147_WWE3C00001G0482	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P147_WWE3C00001G0483	COG0517	IMP dehydrogenase activity
P147_WWE3C00001G0483	COG0516	GMP reductase activity
P147_WWE3C00001G0484	COG4974	Belongs to the 'phage' integrase family
P147_WWE3C00001G0486	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
P147_WWE3C00001G0487	COG0217	transcriptional regulatory protein
P147_WWE3C00001G0492	COG0564	pseudouridine synthase activity
P147_WWE3C00001G0495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P147_WWE3C00001G0497	COG0305	Participates in initiation and elongation during chromosome replication
P147_WWE3C00001G0498	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
P147_WWE3C00001G0500	COG0254	rRNA binding
P147_WWE3C00001G0501	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
P147_WWE3C00001G0502	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P147_WWE3C00001G0503	COG3409	Peptidoglycan-binding domain 1 protein
P147_WWE3C00001G0503	COG0793	Belongs to the peptidase S41A family
P147_WWE3C00001G0506	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P147_WWE3C00001G0508	COG0360	Binds together with S18 to 16S ribosomal RNA
P147_WWE3C00001G0509	COG0012	GTP binding
P147_WWE3C00001G0514	COG0215	cysteine-tRNA ligase activity
P147_WWE3C00001G0516	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P147_WWE3C00001G0517	COG0193	aminoacyl-tRNA hydrolase activity
P147_WWE3C00001G0518	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P147_WWE3C00001G0520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P147_WWE3C00001G0522	COG0233	cytoplasmic translational termination
P147_WWE3C00001G0523	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P147_WWE3C00001G0524	COG0052	Belongs to the universal ribosomal protein uS2 family
P147_WWE3C00001G0531	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P147_WWE3C00001G0532	COG0242	peptide deformylase activity
P147_WWE3C00001G0533	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P147_WWE3C00001G0548	COG0577	efflux transmembrane transporter activity
P147_WWE3C00001G0553	COG0640	Transcriptional regulator
P147_WWE3C00001G0556	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P147_WWE3C00001G0557	COG1994	Peptidase M50
P147_WWE3C00001G0559	COG0250	Participates in transcription elongation, termination and antitermination
P147_WWE3C00001G0560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P147_WWE3C00001G0561	COG0081	regulation of translation
P147_WWE3C00001G0563	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P147_WWE3C00001G0565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
P147_WWE3C00001G0572	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P147_WWE3C00001G0573	COG0222	ribosome binding
P147_WWE3C00001G0575	COG0297	glycogen (starch) synthase activity
P147_WWE3C00001G0578	COG0297	glycogen (starch) synthase activity
P147_WWE3C00001G0591	COG0563	adenylate kinase activity
P147_WWE3C00001G0594	COG0018	arginyl-trna synthetase
P147_WWE3C00001G0597	COG1555	photosystem II stabilization
P147_WWE3C00001G0597	COG1596	polysaccharide export
P147_WWE3C00001G0599	COG0606	chelatase, subunit chli
P147_WWE3C00001G0600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P147_WWE3C00001G0600	COG0758	DNA mediated transformation
P147_WWE3C00001G0604	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
P147_WWE3C00001G0605	COG0739	heme binding
P147_WWE3C00001G0609	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
P147_WWE3C00001G0616	COG4956	integral membrane protein (PIN domain superfamily)
P147_WWE3C00001G0617	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
P147_WWE3C00001G0618	COG0542	response to heat
P147_WWE3C00001G0625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
P147_WWE3C00001G0633	COG0739	heme binding
P147_WWE3C00001G0634	COG0482	sulfurtransferase activity
P147_WWE3C00001G0637	COG0438	transferase activity, transferring glycosyl groups
P147_WWE3C00001G0638	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P147_WWE3C00001G0639	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
P147_WWE3C00001G0641	COG1793	dna ligase
P147_WWE3C00001G0645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P147_WWE3C00001G0646	COG0698	ribose 5-phosphate isomerase
P147_WWE3C00001G0647	COG0352	thiamine-phosphate diphosphorylase activity
P147_WWE3C00001G0649	COG3959	Transketolase, thiamine diphosphate binding domain
P147_WWE3C00001G0651	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
P147_WWE3C00001G0652	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
P147_WWE3C00001G0652	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
P147_WWE3C00001G0653	COG0191	fructose-bisphosphate aldolase activity
P147_WWE3C00001G0654	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
P147_WWE3C00001G0656	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P147_WWE3C00001G0657	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P147_WWE3C00001G0657	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P147_WWE3C00001G0658	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P147_WWE3C00001G0665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P147_WWE3C00001G0666	COG0210	DNA helicase
P147_WWE3C00001G0668	COG1686	Belongs to the peptidase S11 family
P147_WWE3C00001G0669	COG3118	belongs to the thioredoxin family
P147_WWE3C00001G0670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P147_WWE3C00001G0671	COG0126	phosphoglycerate kinase activity
P147_WWE3C00001G0674	COG0149	triose-phosphate isomerase activity
P147_WWE3C00001G0675	COG1316	TRANSCRIPTIONal
P147_WWE3C00001G0682	COG0268	Binds directly to 16S ribosomal RNA
P147_WWE3C00001G0683	COG0728	peptidoglycan biosynthetic process
P147_WWE3C00001G0684	COG0481	GTPase activity
P147_WWE3C00001G0685	COG1420	regulation of RNA biosynthetic process
P147_WWE3C00001G0686	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P147_WWE3C00001G0687	COG0443	Heat shock 70 kDa protein
P147_WWE3C00001G0695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
P147_WWE3C00001G0696	COG0546	phosphoglycolate phosphatase activity
P147_WWE3C00001G0698	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
P147_WWE3C00001G0703	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
P147_WWE3C00001G0705	COG0525	valine-tRNA ligase activity
P147_WWE3C00001G0706	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
P147_WWE3C00001G0711	COG2385	sporulation resulting in formation of a cellular spore
P147_WWE3C00001G0720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P147_WWE3C00001G0734	COG0588	phosphoglycerate mutase activity
P147_WWE3C00001G0737	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
P147_WWE3C00001G0745	COG0358	DNA primase activity
P147_WWE3C00001G0746	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P147_WWE3C00001G0750	COG1970	mechanosensitive ion channel activity
P147_WWE3C00001G0766	COG1196	nuclear chromosome segregation
P147_WWE3C00001G0768	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P147_WWE3C00001G0777	COG0640	Transcriptional regulator
P147_WWE3C00001G0778	COG0396	ATPase activity
P147_WWE3C00001G0779	COG0719	Fe-S assembly protein
P147_WWE3C00001G0780	COG0719	Fe-S assembly protein
P147_WWE3C00001G0781	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P147_WWE3C00001G0782	COG0822	iron-sulfur transferase activity
P147_WWE3C00001G0787	COG4974	Belongs to the 'phage' integrase family
P147_WWE3C00001G0791	COG0180	Tryptophanyl-tRNA synthetase
P147_WWE3C00001G0792	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P147_WWE3C00001G0793	COG0084	hydrolase, TatD family'
P147_WWE3C00001G0795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P147_WWE3C00001G0797	COG0745	RESPONSE REGULATOR receiver
P147_WWE3C00001G0798	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P147_WWE3C00001G0805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P147_WWE3C00001G0806	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P147_WWE3C00001G0807	COG0459	protein refolding
P147_WWE3C00001G0809	COG0328	RNA-DNA hybrid ribonuclease activity
P147_WWE3C00001G0815	COG0592	DNA-directed DNA polymerase activity
P147_WWE3C00001G0817	COG0706	membrane insertase activity
P147_WWE3C00001G0818	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
P147_WWE3C00001G0819	COG0594	ribonuclease P activity
P147_WWE3C00001G0820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P147_WWE3C00001G0820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P147_WWE3C00001G0821	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P147_WWE3C00001G0822	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P147_WWE3C00001G0823	COG0628	permease
P147_WWE3C00001G0826	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
P147_WWE3C00001G0829	COG2884	Cell division ATP-binding protein ftsE
P147_WWE3C00001G0830	COG2177	Part of the ABC transporter FtsEX involved in
P147_WWE3C00001G0834	COG0802	atpase or kinase
P147_WWE3C00001G0837	COG0463	Glycosyl transferase, family 2
P147_WWE3C00001G0847	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
P147_WWE3C00001G0848	COG1872	DUF167
P147_WWE3C00001G0851	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P147_WWE3C00001G0852	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P147_WWE3C00001G0857	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
P147_WWE3C00001G0863	COG1078	dGTPase activity
P147_WWE3C00001G0874	COG0330	HflC and HflK could
P147_WWE3C00001G0875	COG0330	HflC and HflK could
P147_WWE3C00001G0876	COG1968	undecaprenyl-diphosphatase activity
P147_WWE3C00001G0878	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P147_WWE3C00001G0884	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
P147_WWE3C00001G0884	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P147_WWE3C00001G0887	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P147_WWE3C00001G0915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P147_WWE3C00001G0916	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus