locus-tag	class	description
AZF37_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AZF37_00015	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
AZF37_00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AZF37_00025	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
AZF37_00030	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
AZF37_00040	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AZF37_00045	ENOG4105BZU	Histidine kinase
AZF37_00085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
AZF37_00110	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AZF37_00115	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
AZF37_00120	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AZF37_00130	ENOG4108YZG	isomerase
AZF37_00135	ENOG4108UK2	deaminase
AZF37_00140	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AZF37_00150	ENOG4107S4Y	M20 DapE family protein YgeY
AZF37_00155	ENOG4105CH7	arginosuccinase
AZF37_00160	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AZF37_00165	ENOG4108KGH	TRANSCRIPTIONal
AZF37_00175	ENOG4105E3H	phosphoglycerate mutase
AZF37_00190	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
AZF37_00195	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
AZF37_00210	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AZF37_00245	ENOG4108JJB	ABC transporter
AZF37_00290	ENOG4105CJ1	ABC, transporter
AZF37_00295	ENOG4105CJ1	ABC, transporter
AZF37_00300	ENOG4105WH1	Two component transcriptional regulator luxr family
AZF37_00320	ENOG4105CMR	udp-glucose 4-epimerase
AZF37_00325	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AZF37_00340	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AZF37_00345	ENOG4105CRK	lysyL-tRNA synthetase
AZF37_00350	ENOG4105C37	(CBS) domain
AZF37_00355	ENOG4107R73	Mate efflux family protein
AZF37_00365	ENOG4105C87	Aminotransferase class I and II
AZF37_00395	ENOG4105CHR	reductase
AZF37_00410	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
AZF37_00425	ENOG4105UIB	(ABC) transporter
AZF37_00435	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
AZF37_00440	ENOG41080U2	Amidohydrolase family
AZF37_00450	ENOG4108JQ9	ABC transporter
AZF37_00495	ENOG4105DQ6	Transposase
AZF37_00570	ENOG4108IG5	Transcriptional regulator
AZF37_00620	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AZF37_00675	ENOG4108JJB	ABC transporter
AZF37_00680	ENOG4108JJB	ABC transporter
AZF37_00685	ENOG4108JJB	ABC transporter
AZF37_00710	ENOG4108TGC	Acyltransferase
AZF37_00730	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AZF37_00755	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
AZF37_00765	ENOG4105D49	3-dehydroquinate synthase
AZF37_00775	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AZF37_00780	ENOG4105CQC	Prephenate dehydratase
AZF37_00790	ENOG4105DUM	transcriptional regulator, lysR family
AZF37_00805	ENOG4105DFM	M18 family aminopeptidase
AZF37_00810	ENOG4105DFM	M18 family aminopeptidase
AZF37_00865	ENOG4105EMU	Dehydrogenase
AZF37_00870	ENOG4105CHR	reductase
AZF37_00900	ENOG4105DQ6	Transposase
AZF37_00910	ENOG4105CN1	protease
AZF37_00915	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AZF37_00935	ENOG4105JVQ	RNA Polymerase
AZF37_01080	ENOG4105K64	Glycosyl transferase, family 2
AZF37_01085	ENOG4107R6R	udp-galactopyranose mutase
AZF37_01135	ENOG4108RSN	SNARE associated Golgi
AZF37_01140	ENOG4107QR9	Iron-sulfur cluster binding protein
AZF37_01165	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
AZF37_01170	ENOG4107VMI	polysaccharide deacetylase
AZF37_01190	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
AZF37_01195	ENOG4105CHM	Aminotransferase
AZF37_01205	ENOG4105KVH	Transcriptional regulator
AZF37_01275	ENOG4107S4Y	M20 DapE family protein YgeY
AZF37_01310	ENOG4108UQ1	hydrolase, family 25
AZF37_01325	ENOG4105C1J	atp-dependent rna helicase
AZF37_01330	ENOG410838F	Glycosyl transferase family 2
AZF37_01460	ENOG4105SX7	Transporter
AZF37_01465	ENOG4108V8F	Transcriptional regulator, MarR family
AZF37_01490	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
AZF37_01530	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
AZF37_01535	ENOG4105CDY	transcriptional regulatory protein
AZF37_01540	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
AZF37_01545	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
AZF37_01550	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
AZF37_01590	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
AZF37_01600	ENOG4105C7K	acetolactate synthase
AZF37_01605	ENOG4105C7K	acetolactate synthase
AZF37_01610	ENOG4105C7K	acetolactate synthase
AZF37_01670	ENOG4108UQ1	hydrolase, family 25
AZF37_01690	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
AZF37_01695	ENOG4105EHG	Permease protein
AZF37_01710	ENOG4108YZT	Adenosylcobinamide kinase
AZF37_01715	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
AZF37_01720	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
AZF37_01740	ENOG4105CEN	a g-specific adenine glycosylase
AZF37_01755	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZF37_01760	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZF37_01810	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AZF37_01820	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AZF37_01835	ENOG4105ESV	Glycosyl transferase, family 4
AZF37_01840	ENOG4105CEV	competence damage-inducible protein
AZF37_01845	ENOG4105CEV	competence damage-inducible protein
AZF37_01850	ENOG4107QUY	Guanine deaminase
AZF37_01855	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AZF37_01860	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AZF37_01865	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AZF37_01870	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AZF37_01875	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AZF37_01880	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
AZF37_01890	ENOG4105KHC	sulfurtransferase
AZF37_01900	ENOG4105WH5	Teichoic acid glycosylation protein
AZF37_01905	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AZF37_01910	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
AZF37_01915	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
AZF37_01925	ENOG4105CUZ	uba thif-type nad fad binding protein
AZF37_01935	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AZF37_01945	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
AZF37_01955	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AZF37_01960	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AZF37_01970	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
AZF37_01975	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AZF37_01995	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AZF37_02000	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AZF37_02010	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AZF37_02015	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AZF37_02025	ENOG4105KVH	Transcriptional regulator
AZF37_02040	ENOG4105BZ1	(ABC) transporter
AZF37_02055	ENOG4105CCI	Myosin-Cross-Reactive Antigen
AZF37_02080	ENOG4108JJB	ABC transporter
AZF37_02095	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AZF37_02145	ENOG4108JA5	May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity)
AZF37_02200	ENOG4105D98	threonine synthase
AZF37_02205	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AZF37_02210	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
AZF37_02240	ENOG4105EGD	dinuclear metal center protein, YbgI family
AZF37_02245	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
AZF37_02260	ENOG4105CE9	30S ribosomal protein S2
AZF37_02265	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AZF37_02275	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AZF37_02285	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AZF37_02290	ENOG4105KNE	Phosphatidate cytidylyltransferase
AZF37_02295	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AZF37_02300	ENOG4105DZP	Membrane-associated zinc metalloprotease
AZF37_02305	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
AZF37_02310	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AZF37_02315	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
AZF37_02320	ENOG4105CJW	magnesium transporter
AZF37_02325	ENOG4105C6K	Malic enzyme
AZF37_02335	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
AZF37_02365	ENOG4105CJN	penicillin-binding protein
AZF37_02370	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AZF37_02375	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
AZF37_02380	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
AZF37_02385	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
AZF37_02390	ENOG4105CNI	cell division protein FtsW
AZF37_02395	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AZF37_02400	ENOG4105DFU	Cell wall formation (By similarity)
AZF37_02405	ENOG4105D4A	Cell wall formation (By similarity)
AZF37_02410	ENOG4105ME9	cell division protein FtsQ
AZF37_02415	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
AZF37_02425	ENOG4105DFA	alanine racemase domain protein
AZF37_02430	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
AZF37_02440	ENOG4105DBK	s4 domain protein
AZF37_02445	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
AZF37_02450	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
AZF37_02455	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
AZF37_02460	ENOG4105C34	Pseudouridine synthase
AZF37_02465	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
AZF37_02500	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
AZF37_02505	ENOG4105K63	Thioredoxin
AZF37_02510	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
AZF37_02515	ENOG4105CXT	aspartate transcarbamylase
AZF37_02520	ENOG4105CD3	dihydroorotase
AZF37_02525	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
AZF37_02530	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
AZF37_02535	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
AZF37_02540	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
AZF37_02560	ENOG4105F23	Fibronectin-binding protein
AZF37_02570	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
AZF37_02580	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
AZF37_02585	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AZF37_02590	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
AZF37_02595	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
AZF37_02600	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AZF37_02605	ENOG410823V	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AZF37_02625	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
AZF37_02630	ENOG4105CM2	brancheD-chain amino acid aminotransferase
AZF37_02635	ENOG4107BJW	polysaccharide deacetylase
AZF37_02645	ENOG4105VCQ	rubredoxin
AZF37_02740	ENOG4105VC4	domain protein
AZF37_02790	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
AZF37_02795	ENOG4105F1A	Pyruvate formate-lyase
AZF37_02810	ENOG4107QZB	decarboxylase
AZF37_02845	ENOG4105EPR	degv family
AZF37_02850	ENOG4105EPR	degv family
AZF37_02870	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AZF37_02955	ENOG4105GD4	(Histidine triad) protein
AZF37_02960	ENOG4105YB8	TM2 domain containing protein
AZF37_02965	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AZF37_02970	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AZF37_03020	ENOG4105CF7	AraC family transcriptional regulator
AZF37_03030	ENOG4105FDK	ABC transporter
AZF37_03045	ENOG4108V2W	Carbonate dehydratase
AZF37_03050	ENOG4108REF	Sporulation integral membrane protein ytvi
AZF37_03075	ENOG4105CE1	Ferrous iron transport protein b
AZF37_03090	ENOG4105CE1	Ferrous iron transport protein b
AZF37_03120	ENOG4105C2W	permease
AZF37_03125	ENOG4107S4Y	M20 DapE family protein YgeY
AZF37_03130	ENOG4105DBV	ornithine carbamoyltransferase
AZF37_03135	ENOG4105BZ8	glutamate synthase
AZF37_03140	ENOG4107UUR	Chlorohydrolase aminohydrolase
AZF37_03155	ENOG4105C7W	Xanthine dehydrogenase
AZF37_03160	ENOG4105C7W	Xanthine dehydrogenase
AZF37_03170	ENOG4105C7W	Xanthine dehydrogenase
AZF37_03175	ENOG4108HR6	Dehydrogenase
AZF37_03185	ENOG4108UTP	(2Fe-2S)-binding domain protein
AZF37_03200	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AZF37_03215	ENOG4105WDJ	50S ribosomal protein L33
AZF37_03220	ENOG410683Z	Preprotein translocase SecE subunit
AZF37_03225	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
AZF37_03230	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AZF37_03240	ENOG4108VZM	50s ribosomal protein L10
AZF37_03245	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AZF37_03255	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AZF37_03260	ENOG4105XPM	ribosomal protein
AZF37_03265	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AZF37_03270	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AZF37_03275	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AZF37_03280	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AZF37_03285	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AZF37_03290	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AZF37_03295	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AZF37_03300	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AZF37_03305	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AZF37_03310	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AZF37_03315	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AZF37_03320	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AZF37_03325	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AZF37_03330	ENOG41082SA	50s ribosomal protein l29
AZF37_03335	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AZF37_03340	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AZF37_03345	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
AZF37_03355	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AZF37_03360	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AZF37_03365	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AZF37_03370	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
AZF37_03375	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AZF37_03380	ENOG4105VPB	50S ribosomal protein L30
AZF37_03385	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
AZF37_03390	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
AZF37_03400	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
AZF37_03405	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
AZF37_03410	ENOG41067V7	50S ribosomal protein L36
AZF37_03415	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AZF37_03420	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
AZF37_03425	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AZF37_03435	ENOG4108ZT0	50S ribosomal protein l17
AZF37_03490	ENOG4105DCT	glycerol dehydrogenase
AZF37_03540	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AZF37_03580	ENOG4105DQ6	Transposase
AZF37_03585	ENOG4105WMR	Protein CrcB homolog
AZF37_03600	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
AZF37_03625	ENOG4105C1A	potassium transporter peripheral membrane
AZF37_03660	ENOG4108UZE	carboxy-peptidase
AZF37_03685	ENOG4105DGN	Electron transport complex
AZF37_03690	ENOG4105DZB	Electron transport complex
AZF37_03695	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
AZF37_03700	ENOG4105D6A	Electron transport complex
AZF37_03705	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
AZF37_03710	ENOG4105C3G	gtp-binding protein
AZF37_03720	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AZF37_03730	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
AZF37_03735	ENOG4105CHV	Transcription elongation factor NusA
AZF37_03740	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
AZF37_03750	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AZF37_03750	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AZF37_03755	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
AZF37_03760	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
AZF37_03770	ENOG4105DTN	riboflavin biosynthesis protein ribF
AZF37_03775	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AZF37_03785	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AZF37_03805	ENOG4105VB9	50S ribosomal protein l28
AZF37_03810	ENOG4108ZAA	Alkaline-shock protein
AZF37_03815	ENOG4105DP4	dak2 domain fusion protein ylov
AZF37_03820	ENOG4105C1V	Peptidase, M16
AZF37_03825	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
AZF37_03840	ENOG4105VJV	50s ribosomal protein L35
AZF37_03845	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AZF37_03850	ENOG4108RWN	rrna methyltransferase
AZF37_03870	ENOG4105BZA	Phosphoglycerate kinase
AZF37_03880	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AZF37_03885	ENOG4105XZU	Preprotein translocase, subunit SecG
AZF37_03890	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
AZF37_03895	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AZF37_03905	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AZF37_03910	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
AZF37_03925	ENOG4105UQX	Mate efflux family protein
AZF37_03960	ENOG4105EAB	amino acid AbC transporter
AZF37_03965	ENOG4105E5Q	amino acid AbC transporter
AZF37_03970	ENOG4105CDA	abc transporter atp-binding protein
AZF37_03980	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AZF37_03985	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AZF37_03990	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
AZF37_03995	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
AZF37_04000	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
AZF37_04005	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AZF37_04010	ENOG4105CSA	Coproporphyrinogen iii oxidase
AZF37_04015	ENOG4105CIZ	coA-substrate-specific enzyme activase
AZF37_04020	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AZF37_04080	ENOG4107QSA	Oxaloacetate decarboxylase
AZF37_04085	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AZF37_04150	ENOG4105G5W	regulator Fur family
AZF37_04160	ENOG4105FDK	ABC transporter
AZF37_04230	ENOG4108IJ8	ABC transporter
AZF37_04250	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
AZF37_04255	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AZF37_04265	ENOG4105C7H	Helicase, RecD TraA family
AZF37_04270	ENOG4105C8J	)-transporter
AZF37_04295	ENOG4105DSJ	YicC domain protein
AZF37_04300	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AZF37_04315	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AZF37_04335	ENOG4105CFP	Peptidase U32
AZF37_04340	ENOG4105CFP	Peptidase U32
AZF37_04370	ENOG4105C98	muts2 protein
AZF37_04375	ENOG4105C98	muts2 protein
AZF37_04390	ENOG4105EQI	Metal Dependent Phosphohydrolase
AZF37_04395	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
AZF37_04405	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
AZF37_04420	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
AZF37_04430	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
AZF37_04435	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AZF37_04440	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
AZF37_04445	ENOG4108V0P	LemA family
AZF37_04480	ENOG4105C25	Primosomal protein n'
AZF37_04485	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AZF37_04490	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AZF37_04505	ENOG4108ZF3	Phosphatase
AZF37_04510	ENOG4105D9P	serine threonine protein kinase
AZF37_04515	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AZF37_04520	ENOG4105DJV	ribulose-phosphate 3-epimerase
AZF37_04530	ENOG4107TB6	phosphoglycerate mutase
AZF37_04540	ENOG4106H78	methyltransferase
AZF37_04550	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AZF37_04565	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AZF37_04575	ENOG4105CJ1	ABC, transporter
AZF37_04600	ENOG4105DAP	Nicotinate phosphoribosyltransferase
AZF37_04605	ENOG4108N5C	SNARE associated Golgi protein-related protein
AZF37_04610	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AZF37_04620	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
AZF37_04625	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AZF37_04640	ENOG4105CNU	cell division protein FtsK
AZF37_04645	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
AZF37_04655	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
AZF37_04660	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
AZF37_04665	ENOG4108VQJ	O-methyltransferase
AZF37_04670	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
AZF37_04675	ENOG4108Z4T	Peptidase M50
AZF37_04680	ENOG4105C31	Tryptophanyl-tRNA synthetase
AZF37_04685	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
AZF37_04695	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AZF37_04740	ENOG4105D6E	homoserine dehydrogenase
AZF37_04750	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
AZF37_04755	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AZF37_04760	ENOG4105DC1	bifunctional purine biosynthesis protein purh
AZF37_04790	ENOG4105K5M	30s ribosomal protein S16
AZF37_04800	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
AZF37_04805	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AZF37_04810	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AZF37_04820	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
AZF37_04825	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AZF37_04830	ENOG4105FE9	pseudouridine synthase
AZF37_04840	ENOG4105CBX	hi0933 family
AZF37_04850	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
AZF37_04860	ENOG4106DSS	Tartrate dehydratase subunit alpha
AZF37_04870	ENOG4105CPF	Cell wall formation (By similarity)
AZF37_04895	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AZF37_04900	ENOG4105CXI	aluminum resistance protein
AZF37_04905	ENOG41067MG	lrgb family
AZF37_04910	ENOG41083D3	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity)
AZF37_04915	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
AZF37_04920	ENOG4108UMI	ABC transporter, permease
AZF37_04925	ENOG4105D01	(LipO)protein
AZF37_04960	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
AZF37_04965	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AZF37_04970	ENOG4105CRQ	synthase (Component I)
AZF37_04975	ENOG4105CRQ	synthase (Component I)
AZF37_04980	ENOG4105D1H	recombination factor protein RarA
AZF37_04985	ENOG4105C9M	aspartyl-trna synthetase
AZF37_04990	ENOG4105CUT	histidyl-tRNA synthetase
AZF37_04995	ENOG4105C5X	domain protein
AZF37_05000	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AZF37_05005	ENOG4107SBW	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AZF37_05010	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AZF37_05020	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AZF37_05040	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AZF37_05045	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
AZF37_05075	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
AZF37_05080	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AZF37_05085	ENOG4105KG3	cytidine deaminase
AZF37_05090	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AZF37_05095	ENOG4105C9A	Phoh family
AZF37_05110	ENOG4105CX6	glutaminyL-tRNA synthetase
AZF37_05115	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AZF37_05120	ENOG4107YU2	histidine triad (hIT) protein
AZF37_05125	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AZF37_05130	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
AZF37_05135	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
AZF37_05150	ENOG4107SUZ	Sodium/hydrogen exchanger family
AZF37_05155	ENOG4107SUZ	Sodium/hydrogen exchanger family
AZF37_05160	ENOG4105EEQ	Na H antiporter
AZF37_05185	ENOG4108JJB	ABC transporter
AZF37_05190	ENOG4108JJB	ABC transporter
AZF37_05195	ENOG4108JJB	ABC transporter
AZF37_05210	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AZF37_05215	ENOG4105CFG	Acts as a chaperone (By similarity)
AZF37_05220	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AZF37_05225	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AZF37_05255	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
AZF37_05260	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
AZF37_05265	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
AZF37_05290	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
AZF37_05295	ENOG4105KGF	protein, YerC YecD
AZF37_05300	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
AZF37_05310	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
AZF37_05335	ENOG4105CJ3	phosphate transporter
AZF37_05340	ENOG4105C5H	ABC transporter
AZF37_05360	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
AZF37_05395	ENOG4105CN5	Metallo-Beta-Lactamase
AZF37_05445	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
AZF37_05450	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
AZF37_05455	ENOG4105CYW	agmatinase
AZF37_05460	ENOG4105CXN	decarboxylase
AZF37_05465	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
AZF37_05470	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
AZF37_05475	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
AZF37_05480	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AZF37_05485	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AZF37_05510	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
AZF37_05520	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
AZF37_05525	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AZF37_05530	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
AZF37_05535	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AZF37_05545	ENOG4105DQR	SNARE associated Golgi
AZF37_05550	ENOG4105CTB	Polyprenyl synthetase
AZF37_05560	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AZF37_05570	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AZF37_05575	ENOG4105BZ8	glutamate synthase
AZF37_05580	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
AZF37_05595	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AZF37_05600	ENOG4105DC7	peptidase M24
AZF37_05605	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
AZF37_05610	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
AZF37_05615	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
AZF37_05620	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
AZF37_05630	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
AZF37_05635	ENOG4105CFP	Peptidase U32
AZF37_05645	ENOG41085AS	UPF0473 protein
AZF37_05650	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AZF37_05655	ENOG4105VBH	UPF0297 protein
AZF37_05660	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AZF37_05665	ENOG4105MCT	stage V sporulation protein S
AZF37_05670	ENOG4105D48	metallophosphoesterase
AZF37_05675	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
AZF37_05680	ENOG410691R	Modulates RecA activity (By similarity)
AZF37_05695	ENOG4105DZC	cytosine deaminase
AZF37_05715	ENOG4108317	Binds directly to 16S ribosomal RNA (By similarity)
AZF37_05745	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
AZF37_05755	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
AZF37_05760	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
AZF37_05765	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
AZF37_05775	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AZF37_05780	ENOG4105K46	50S ribosomal protein l27
AZF37_05825	ENOG4105CNI	cell division protein FtsW
AZF37_05845	ENOG4105DFF	Rod shape-determining protein mreb
AZF37_05850	ENOG4105W5Q	DNA repair protein (RadC
AZF37_05855	ENOG4105W5Q	DNA repair protein (RadC
AZF37_05865	ENOG4108Z03	MAF-like protein
AZF37_05880	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AZF37_05885	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
AZF37_05915	ENOG4107QYV	phosphohexose isomerase
AZF37_05955	ENOG4105BZU	Histidine kinase
AZF37_05995	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AZF37_06000	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
AZF37_06020	ENOG4105CHM	Aminotransferase
AZF37_06025	ENOG4105C8T	Leucyl-tRNA synthetase
AZF37_06095	ENOG4108Q52	Methyltransferase cognate corrinoid protein
AZF37_06140	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
AZF37_06155	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
AZF37_06160	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
AZF37_06165	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
AZF37_06170	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
AZF37_06175	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
AZF37_06180	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AZF37_06200	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AZF37_06205	ENOG4105CNW	domain protein
AZF37_06215	ENOG4105C7W	Xanthine dehydrogenase
AZF37_06225	ENOG4105C7W	Xanthine dehydrogenase
AZF37_06250	ENOG4105E0C	molybdate abc transporter
AZF37_06255	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
AZF37_06260	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
AZF37_06270	ENOG4105CIN	aminoacyl-histidine dipeptidase
AZF37_06330	ENOG4105X71	Membrane
AZF37_06405	ENOG4105C7W	Xanthine dehydrogenase
AZF37_06480	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
AZF37_06505	ENOG4105C7W	Xanthine dehydrogenase
AZF37_06570	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
AZF37_06575	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
AZF37_06590	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
AZF37_06615	ENOG4105VZ8	Transcriptional regulator
AZF37_06625	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
AZF37_06635	ENOG4105MAX	Superoxide reductase
AZF37_06655	ENOG4107STF	Involved in phosphonate degradation (By similarity)
AZF37_06710	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
AZF37_06715	ENOG4105C0B	DNA polymerase III (alpha subunit)
AZF37_06735	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
AZF37_06760	ENOG4108RAC	Rubrerythrin
AZF37_06770	ENOG4107RWR	Sodium hydrogen exchanger
AZF37_06775	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
AZF37_06820	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AZF37_06825	ENOG4105EEI	dihydropteroate synthase
AZF37_06835	ENOG4105CRQ	synthase (Component I)
AZF37_06870	ENOG4105BZ1	(ABC) transporter
AZF37_06875	ENOG410801F	ribosomal-protein-alanine acetyltransferase
AZF37_06880	ENOG41072GX	Peptidase M22 Glycoprotease
AZF37_06885	ENOG4105K8N	protein family UPF0079, ATPase
AZF37_06890	ENOG4105CI2	imidazolone-5-propionate hydrolase
AZF37_06895	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AZF37_06900	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
AZF37_06905	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
AZF37_06980	ENOG4105D52	delta-aminolevulinic acid dehydratase
AZF37_07015	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
AZF37_07025	ENOG4105ETE	Transcriptional regulator (LacI family
AZF37_07050	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AZF37_07085	ENOG4107RBB	ABC transporter, permease
AZF37_07130	ENOG4108D32	Methyltransferase
AZF37_07155	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AZF37_07185	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AZF37_07295	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
AZF37_07300	ENOG4105EPR	degv family
AZF37_07320	ENOG4105C2W	permease
AZF37_07325	ENOG4105C2W	permease
AZF37_07330	ENOG4105C2W	permease
AZF37_07400	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
AZF37_07410	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
AZF37_07460	ENOG4105BZ4	penicillin-binding protein
AZF37_07465	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
AZF37_07470	ENOG4105BZ4	penicillin-binding protein
AZF37_07485	ENOG4105DQ6	Transposase
AZF37_07490	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AZF37_07495	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
AZF37_07500	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AZF37_07505	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AZF37_07525	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
AZF37_07530	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AZF37_07540	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
AZF37_07545	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AZF37_07550	ENOG4105C2M	dna polymerase I
AZF37_07580	ENOG4105UIB	(ABC) transporter
AZF37_07585	ENOG4108JQ9	ABC transporter
AZF37_07590	ENOG4105C2J	ABC transporter
AZF37_07595	ENOG4108JQ9	ABC transporter
AZF37_07620	ENOG4108VXD	carboxy-peptidase
AZF37_07640	ENOG4105CAQ	asparagine synthetase
AZF37_07650	ENOG4105C3M	thioredoxin reductase
AZF37_07655	ENOG4105C0H	protease
AZF37_07665	ENOG4107Y9E	nuclease
AZF37_07675	ENOG4105C22	threonyL-tRNA synthetase
AZF37_07710	ENOG4108IJ6	ABC transporter
AZF37_07715	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
AZF37_07735	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
AZF37_07750	ENOG4105C2N	RNA methyltransferase TrmH family group 3
AZF37_07755	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
AZF37_07765	ENOG4105C8N	cysteinyl-tRNA synthetase
AZF37_07770	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
AZF37_07780	ENOG4105CTP	PilT protein domain protein
AZF37_07785	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
AZF37_07790	ENOG4107XAV	metallophosphoesterase
AZF37_07805	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
AZF37_07830	ENOG4107RCH	Diaminopropionate ammonia-lyase
AZF37_07835	ENOG4108Z6B	deaminase
AZF37_07875	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
AZF37_07885	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
AZF37_07890	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
AZF37_07895	ENOG4105K4W	Could be involved in septation (By similarity)
AZF37_07900	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AZF37_07905	ENOG4107T7U	Sulfatase
AZF37_07970	ENOG4105CIZ	coA-substrate-specific enzyme activase
AZF37_07975	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
AZF37_07980	ENOG4108IG5	Transcriptional regulator
AZF37_07985	ENOG4105CJ1	ABC, transporter
AZF37_08080	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AZF37_08085	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AZF37_08090	ENOG4105CPN	adenine deaminase
AZF37_08095	ENOG4105C7N	Xanthine uracil vitamin C permease
AZF37_08120	ENOG4108Q52	Methyltransferase cognate corrinoid protein
AZF37_08165	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AZF37_08170	ENOG4105F8V	Hydrolase, tatD family
AZF37_08175	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
AZF37_08185	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
AZF37_08195	ENOG4105MA4	psp1 domain protein
AZF37_08205	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AZF37_08220	ENOG4105CXN	decarboxylase
AZF37_08225	ENOG4105C28	cystathionine
AZF37_08260	ENOG4105CHM	Aminotransferase
AZF37_08270	ENOG4105C5I	Dehydrogenase
AZF37_08280	ENOG4105KWG	Pfam:DUF1696
AZF37_08315	ENOG4107SSZ	Phosphatase
AZF37_08325	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AZF37_08330	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AZF37_08355	ENOG4105C9U	ATP-dependent DNA helicase RecQ
AZF37_08360	ENOG4105C59	p-type ATPase
AZF37_08370	ENOG4107TE5	Lipid kinase
AZF37_08390	ENOG4108UUM	single-stranded DNA-binding protein
AZF37_08395	ENOG4105VDK	protein, conserved in bacteria
AZF37_08435	ENOG4105MZU	cell filamentation protein
AZF37_08445	ENOG4107TH8	cina domain protein
AZF37_08455	ENOG4105D2N	Aldolase
AZF37_08480	ENOG4108UJD	30S ribosomal protein S9
AZF37_08485	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AZF37_08490	ENOG4105VXR	cytoplasmic protein
AZF37_08510	ENOG4105DBV	ornithine carbamoyltransferase
AZF37_08515	ENOG4105C8Y	Acetylornithine aminotransferase
AZF37_08520	ENOG4105CAS	nag kinase
AZF37_08525	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
AZF37_08530	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
AZF37_08575	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
AZF37_08580	ENOG4105CPN	adenine deaminase
AZF37_08600	ENOG4105FDP	GntR family transcriptional regulator
AZF37_08605	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
AZF37_08610	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
AZF37_08620	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
AZF37_08625	ENOG4105CDU	Replicative dna helicase
AZF37_08630	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
AZF37_08670	ENOG4105C83	adenylosuccinate lyase
AZF37_08720	ENOG4105KWG	Pfam:DUF1696
AZF37_08725	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AZF37_08760	ENOG4105YA8	Transcriptional regulator
AZF37_08850	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AZF37_08855	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AZF37_08860	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AZF37_08885	ENOG4105CE1	Ferrous iron transport protein b
AZF37_08890	ENOG4107QW4	alcohol dehydrogenase
AZF37_08895	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
AZF37_08940	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
AZF37_08945	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AZF37_08955	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
AZF37_08960	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
AZF37_09015	ENOG4105DQ6	Transposase
AZF37_09060	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
AZF37_09065	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
AZF37_09080	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
AZF37_09085	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
AZF37_09090	ENOG4105CHR	reductase
AZF37_09095	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
AZF37_09100	ENOG4105EA8	2-Nitropropane dioxygenase
AZF37_09105	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
AZF37_09110	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
AZF37_09115	ENOG4108FRU	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
AZF37_09120	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
AZF37_09125	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
AZF37_09135	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AZF37_09140	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
AZF37_09155	ENOG4105CKU	formyltetrahydrofolate synthetase
AZF37_09160	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
AZF37_09170	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AZF37_09205	ENOG41060GV	RNA binding s1 domain protein
AZF37_09230	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
AZF37_09245	ENOG4108JA2	transcriptioN-repair coupling factor
AZF37_09260	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AZF37_09265	ENOG4105C6E	dna polymerase iii
AZF37_09330	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
AZF37_09355	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
AZF37_09360	ENOG4105CAK	Cell division ATP-binding protein ftsE
AZF37_09365	ENOG4108IUS	Transketolase
AZF37_09370	ENOG4108HHA	Transketolase
AZF37_09415	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AZF37_09420	ENOG4105CSM	endonuclease III
AZF37_09425	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
AZF37_09435	ENOG4105DBI	uridine monophosphokinase
AZF37_09445	ENOG4105C34	Pseudouridine synthase
AZF37_09450	ENOG4105DR9	pseudouridine synthase
AZF37_09455	ENOG4105FDU	atp-dependent rna helicase
AZF37_09460	ENOG4107XGZ	Hydrolase
AZF37_09465	ENOG4105WPN	DNA integration recombination invertion protein
AZF37_09500	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AZF37_09505	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
AZF37_09510	ENOG4108JJB	ABC transporter
AZF37_09515	ENOG4108JJB	ABC transporter
AZF37_09610	ENOG4107QJE	Chromosome Partitioning Protein
AZF37_09615	ENOG4105FA0	parb-like partition protein
AZF37_09620	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AZF37_09625	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
AZF37_09630	ENOG4105EM7	Selenocysteine-specific translation elongation factor
AZF37_09635	ENOG4108VPT	UPF0234 protein
AZF37_09660	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
AZF37_09705	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
AZF37_09800	ENOG4105CAR	Terminase, large subunit
AZF37_09845	ENOG4105C8J	)-transporter