locus-tag	class	description
I862_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I862_00015	COG0052	Belongs to the universal ribosomal protein uS2 family
I862_00020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I862_00030	COG0233	cytoplasmic translational termination
I862_00040	COG0328	RNA-DNA hybrid ribonuclease activity
I862_00050	COG0793	Belongs to the peptidase S41A family
I862_00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I862_00065	COG1749	Flagellar hook protein flgE
I862_00070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I862_00075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I862_00090	COG4120	Belongs to the binding-protein-dependent transport system permease family
I862_00125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I862_00135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I862_00160	COG2204	response regulator
I862_00170	COG0592	DNA-directed DNA polymerase activity
I862_00175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I862_00180	COG1040	competence protein
I862_00190	COG2226	methyltransferase
I862_00205	COG0181	hydroxymethylbilane synthase activity
I862_00215	COG2094	Belongs to the DNA glycosylase MPG family
I862_00230	COG0268	Binds directly to 16S ribosomal RNA
I862_00235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I862_00245	COG1566	PFAM secretion protein HlyD family protein
I862_00250	COG2814	Major facilitator Superfamily
I862_00255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I862_00260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I862_00265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I862_00275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I862_00280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I862_00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I862_00305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I862_00315	COG0039	L-malate dehydrogenase activity
I862_00325	COG0666	response to abiotic stimulus
I862_00330	COG2027	D-alanyl-D-alanine carboxypeptidase
I862_00340	COG0795	lipopolysaccharide-transporting ATPase activity
I862_00345	COG0542	response to heat
I862_00380	COG1230	cation diffusion facilitator family transporter
I862_00385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I862_00410	COG0439	Biotin carboxylase
I862_00440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I862_00455	COG0348	domain, Protein
I862_00500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I862_00510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I862_00510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I862_00520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I862_00520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I862_00545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I862_00560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I862_00560	COG0456	acetyltransferase
I862_00570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I862_00575	COG0740	serine-type endopeptidase activity
I862_00580	COG0544	peptidyl-prolyl cis-trans isomerase activity
I862_00585	COG2217	Heavy metal translocating P-type atpase
I862_00610	COG2003	Belongs to the UPF0758 family
I862_00615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I862_00635	COG1131	(ABC) transporter
I862_00640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I862_00650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I862_00660	COG2823	Periplasmic or secreted lipoprotein
I862_00665	COG2823	Periplasmic or secreted lipoprotein
I862_00680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I862_00685	COG3178	'Phosphotransferase
I862_00695	COG0321	lipoyl(octanoyl) transferase activity
I862_00705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I862_00710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I862_00715	COG1573	uracil-dna glycosylase
I862_00725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I862_00730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I862_00735	COG0575	Belongs to the CDS family
I862_00740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I862_00755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I862_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
I862_00775	COG0531	amino acid
I862_00780	COG0071	Belongs to the small heat shock protein (HSP20) family
I862_00805	COG1074	ATP-dependent DNA helicase activity
I862_00810	COG3220	belongs to the UPF0276 family
I862_00820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I862_00835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I862_00840	COG0723	plastoquinol--plastocyanin reductase activity
I862_00860	COG0484	heat shock protein binding
I862_00870	COG2155	Conserved Protein
I862_00890	COG0783	Belongs to the Dps family
I862_00895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I862_00900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I862_00915	COG0779	Required for maturation of 30S ribosomal subunits
I862_00920	COG1218	3'(2'),5'-bisphosphate nucleotidase
I862_00925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I862_00940	COG4285	Biotin-protein ligase, N terminal
I862_00945	COG5002	protein histidine kinase activity
I862_00950	COG0189	ligase activity
I862_00950	COG4067	protein conserved in archaea
I862_00955	COG1214	PFAM Peptidase M22, glycoprotease
I862_00965	COG0484	heat shock protein binding
I862_00970	COG1331	Highly conserved protein containing a thioredoxin domain
I862_00980	COG0723	plastoquinol--plastocyanin reductase activity
I862_01025	COG4974	Belongs to the 'phage' integrase family
I862_01030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I862_01040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I862_01050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I862_01075	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I862_01095	COG0242	peptide deformylase activity
I862_01100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I862_01105	COG0772	Belongs to the SEDS family
I862_01110	COG0772	Belongs to the SEDS family
I862_01120	COG1278	Cold shock
I862_01150	COG0776	regulation of translation
I862_01155	COG0616	signal peptide processing
I862_01175	COG1012	belongs to the aldehyde dehydrogenase family
I862_01180	COG0823	Involved in the tonB-independent uptake of proteins
I862_01185	COG1942	4-Oxalocrotonate Tautomerase
I862_01190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I862_01205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I862_01210	COG0571	ribonuclease III activity
I862_01215	COG0681	Belongs to the peptidase S26 family
I862_01235	COG0590	tRNA wobble adenosine to inosine editing
I862_01240	COG2211	Major facilitator Superfamily
I862_01245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I862_01270	COG1187	pseudouridine synthase activity
I862_01275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I862_01295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I862_01295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I862_01310	COG0745	RESPONSE REGULATOR receiver
I862_01395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I862_01445	COG1193	negative regulation of DNA recombination
I862_01495	COG0285	dihydrofolate synthase activity
I862_01500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I862_01505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I862_01530	COG1034	ATP synthesis coupled electron transport
I862_01535	COG0655	NAD(P)H dehydrogenase (quinone) activity
I862_01540	COG2814	Major facilitator Superfamily
I862_01555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I862_01555	COG2890	protein-(glutamine-N5) methyltransferase activity
I862_01560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I862_01565	COG0745	RESPONSE REGULATOR receiver
I862_01570	COG1396	sequence-specific DNA binding
I862_01575	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I862_01595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I862_01620	COG0805	protein transport
I862_01660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I862_01665	COG1357	PFAM Pentapeptide repeats (8 copies)
I862_01705	COG1722	exodeoxyribonuclease VII activity
I862_01730	COG3660	Nucleoside-diphosphate-sugar epimerase
I862_01735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I862_01760	COG0745	RESPONSE REGULATOR receiver
I862_01775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I862_01780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I862_01785	COG1459	type II secretion system
I862_01800	COG0101	tRNA pseudouridine synthase activity
I862_01805	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I862_01805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I862_01810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I862_01815	COG0666	response to abiotic stimulus
I862_01820	COG0156	8-amino-7-oxononanoate synthase activity
I862_01830	COG0124	histidyl-tRNA synthetase
I862_01835	COG1192	Involved in chromosome partitioning
I862_01870	COG0849	cell division
I862_01880	COG1181	Belongs to the D-alanine--D-alanine ligase family
I862_01895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I862_01900	COG0424	maF-like protein
I862_01910	COG0045	succinate-CoA ligase (ADP-forming) activity
I862_01920	COG0742	ribosomal rna small subunit methyltransferase
I862_01930	COG2801	Transposase and inactivated derivatives
I862_01935	COG2963	transposase activity
I862_01985	COG1376	ErfK ybiS ycfS ynhG family protein
I862_01990	COG2801	Transposase and inactivated derivatives
I862_01995	COG2963	transposase activity
I862_02040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I862_02060	COG1819	glycosyl
I862_02105	COG2801	Transposase and inactivated derivatives
I862_02115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I862_02115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I862_02125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I862_02130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I862_02135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I862_02195	COG5002	protein histidine kinase activity
I862_02200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I862_02210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I862_02210	COG0517	IMP dehydrogenase activity
I862_02235	COG1970	mechanosensitive ion channel activity
I862_02245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I862_02260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I862_02270	COG1862	Preprotein translocase
I862_02275	COG2226	methyltransferase
I862_02280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I862_02285	COG1360	Flagellar Motor Protein
I862_02295	COG0471	metal ion transport
I862_02300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I862_02345	COG0552	protein localization to endoplasmic reticulum
I862_02350	COG0552	protein localization to endoplasmic reticulum
I862_02360	COG1073	alpha beta
I862_02365	COG0492	ferredoxin-NADP+ reductase activity
I862_02370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I862_02375	COG1295	ribonuclease BN
I862_02390	COG0708	Exodeoxyribonuclease III
I862_02395	COG5464	transposase or invertase
I862_02410	COG0556	nucleotide-excision repair
I862_02425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I862_02440	COG1028	Short-chain dehydrogenase reductase Sdr
I862_02445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I862_02460	COG0728	peptidoglycan biosynthetic process
I862_02465	COG0335	large ribosomal subunit rRNA binding
I862_02470	COG0336	Belongs to the RNA methyltransferase TrmD family
I862_02480	COG0228	four-way junction DNA binding
I862_02500	COG0489	protein tyrosine kinase activity
I862_02505	COG0330	HflC and HflK could
I862_02535	COG1959	2 iron, 2 sulfur cluster binding
I862_02550	COG4133	protoheme IX ABC transporter activity
I862_02555	COG1132	(ABC) transporter
I862_02560	COG1530	ribonuclease E activity
I862_02570	COG0193	aminoacyl-tRNA hydrolase activity
I862_02575	COG0012	GTP binding
I862_02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I862_02625	COG3706	GGDEF domain
I862_02625	COG0745	RESPONSE REGULATOR receiver
I862_02640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I862_02645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I862_02650	COG1494	fructose-1,6-bisphosphatase
I862_02665	COG0473	3-isopropylmalate dehydrogenase activity
I862_02670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I862_02675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I862_02700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I862_02705	COG3307	-O-antigen
I862_02800	COG4695	Portal protein
I862_02845	COG0604	alcohol dehydrogenase
I862_02850	COG0612	Peptidase, M16
I862_02865	COG0281	malic enzyme
I862_02865	COG0280	phosphate acetyltransferase
I862_02870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I862_02875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I862_02890	COG1381	Involved in DNA repair and RecF pathway recombination
I862_02900	COG0776	regulation of translation
I862_02905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I862_02910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I862_02915	COG4974	Belongs to the 'phage' integrase family
I862_02925	COG0009	L-threonylcarbamoyladenylate synthase
I862_02940	COG1007	ATP synthesis coupled electron transport
I862_02955	COG0713	ATP synthesis coupled electron transport
I862_02985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I862_03035	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I862_03065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I862_03070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I862_03120	COG1053	succinate dehydrogenase
I862_03125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I862_03130	COG2009	succinate dehydrogenase
I862_03140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I862_03150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I862_03155	COG1322	Protein conserved in bacteria
I862_03195	COG0170	dolichyl monophosphate biosynthetic process
I862_03205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I862_03215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I862_03245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I862_03250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I862_03265	COG3243	poly(R)-hydroxyalkanoic acid synthase
I862_03275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I862_03300	COG0531	amino acid
I862_03315	COG0384	phenazine biosynthesis protein PhzF
I862_03320	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I862_03330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I862_03335	COG1987	bacterial-type flagellum assembly
I862_03340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I862_03350	COG0504	CTP synthase activity
I862_03360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I862_03365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I862_03375	COG0006	proline dipeptidase activity
I862_03380	COG0006	proline dipeptidase activity
I862_03390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I862_03410	COG1132	(ABC) transporter
I862_03415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I862_03420	COG1028	Short-chain dehydrogenase reductase Sdr
I862_03425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I862_03440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I862_03445	COG2171	N-acyltransferase activity
I862_03465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I862_03490	COG0697	spore germination
I862_03500	COG4251	negative regulation of phosphorylation
I862_03515	COG3202	ADP transmembrane transporter activity
I862_03525	COG0606	chelatase, subunit chli
I862_03530	COG2205	protein histidine kinase activity
I862_03550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I862_03555	COG0085	RNA polymerase activity
I862_03560	COG0222	ribosome binding
I862_03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I862_03570	COG0081	regulation of translation
I862_03575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I862_03595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I862_03600	COG1137	ATPase activity
I862_03610	COG0543	2 iron, 2 sulfur cluster binding
I862_03610	COG0493	'glutamate synthase
I862_03615	COG1872	DUF167
I862_03620	COG1706	bacterial-type flagellum-dependent cell motility
I862_03650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I862_03655	COG0752	glycyl-tRNA synthetase alpha subunit
I862_03685	COG4106	trans-aconitate 2-methyltransferase activity
I862_03700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I862_03710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I862_03715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I862_03730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I862_03735	COG1136	(ABC) transporter
I862_03740	COG2255	four-way junction helicase activity
I862_03750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I862_03770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I862_03780	COG1028	Short-chain dehydrogenase reductase Sdr
I862_03790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I862_03815	COG0189	ligase activity
I862_03830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I862_03840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I862_03850	COG1301	dicarboxylic acid transport
I862_03875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I862_03880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I862_03890	COG0495	leucyl-tRNA aminoacylation
I862_03900	COG0113	porphobilinogen synthase activity
I862_03920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I862_03935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I862_03940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I862_03950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I862_03955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I862_03960	COG0142	geranyltranstransferase activity
I862_03965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I862_03970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I862_03975	COG0792	nuclease activity
I862_03990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I862_04000	COG1560	Kdo2-lipid A biosynthetic process
I862_04010	COG1686	Belongs to the peptidase S11 family
I862_04030	COG2814	Major facilitator Superfamily
I862_04045	COG2205	protein histidine kinase activity
I862_04045	COG2202	Pas domain
I862_04050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I862_04055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I862_04060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I862_04070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I862_04075	COG2205	protein histidine kinase activity
I862_04080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I862_04085	COG0166	Belongs to the GPI family
I862_04090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I862_04095	COG2001	Belongs to the MraZ family
I862_04125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I862_04135	COG2202	Pas domain
I862_04135	COG2205	protein histidine kinase activity
I862_04140	COG0745	RESPONSE REGULATOR receiver
I862_04150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I862_04155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I862_04165	COG4974	Belongs to the 'phage' integrase family
I862_04320	COG0616	signal peptide processing
I862_04345	COG1475	DNA binding
I862_04400	COG0666	response to abiotic stimulus
I862_04415	COG2801	Transposase and inactivated derivatives
I862_04465	COG1338	Plays a role in the flagellum-specific transport system
I862_04475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I862_04485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I862_04490	COG0494	nUDIX hydrolase
I862_04495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I862_04500	COG0629	single-stranded DNA binding
I862_04505	COG0254	rRNA binding
I862_04515	COG0799	negative regulation of ribosome biogenesis
I862_04520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I862_04525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I862_04530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I862_04540	COG0768	penicillin binding
I862_04550	COG0302	gtp cyclohydrolase
I862_04580	COG0697	spore germination
I862_04605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I862_04610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I862_04615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I862_04635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I862_04645	COG3577	Aspartyl protease
I862_04650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I862_04660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I862_04670	COG1253	flavin adenine dinucleotide binding
I862_04675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I862_04680	COG1702	phosphate starvation-inducible protein PhoH
I862_04700	COG1686	Belongs to the peptidase S11 family
I862_04705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I862_04745	COG3736	Type IV secretory pathway, component VirB8
I862_04755	COG2948	multi-organism process
I862_04775	COG1294	oxidase, subunit
I862_04780	COG1271	oxidase subunit
I862_04805	COG2963	transposase activity
I862_04810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I862_04815	COG1132	(ABC) transporter
I862_04820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I862_04830	COG1253	flavin adenine dinucleotide binding
I862_04840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I862_04850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I862_04860	COG1570	exodeoxyribonuclease VII activity
I862_04865	COG4786	Flagellar basal body rod
I862_04870	COG4786	Flagellar basal body rod
I862_04880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I862_04905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I862_04920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I862_04935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I862_04945	COG1677	Flagellar hook-basal body complex protein FliE
I862_04950	COG1558	bacterial-type flagellum-dependent cell motility
I862_04955	COG1815	bacterial-type flagellum-dependent cell motility
I862_04960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I862_04980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I862_04990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I862_04995	COG0416	fatty acid biosynthetic process
I862_05000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I862_05040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I862_05050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I862_05055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I862_05065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I862_05070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I862_05075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I862_05080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I862_05085	COG1185	polyribonucleotide nucleotidyltransferase activity
I862_05095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I862_05110	COG0508	dehydrogenase complex catalyzes the overall conversion of
I862_05115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I862_05140	COG2902	Dehydrogenase
I862_05155	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I862_05160	COG0587	DNA-directed DNA polymerase activity
I862_05210	COG3827	peptidoglycan binding
I862_05225	COG0745	RESPONSE REGULATOR receiver
I862_05230	COG0745	RESPONSE REGULATOR receiver
I862_05260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I862_05260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I862_05270	COG1058	Belongs to the CinA family
I862_05270	COG1546	Belongs to the CinA family
I862_05280	COG1472	Belongs to the glycosyl hydrolase 3 family
I862_05295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I862_05335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I862_05355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I862_05360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I862_05375	COG0450	alkyl hydroperoxide reductase
I862_05380	COG0492	ferredoxin-NADP+ reductase activity
I862_05405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I862_05425	COG2204	response regulator
I862_05435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I862_05445	COG1215	transferase activity, transferring glycosyl groups
I862_05450	COG2867	negative regulation of translational initiation
I862_05455	COG1426	Protein conserved in bacteria
I862_05465	COG0126	phosphoglycerate kinase activity
I862_05470	COG1714	RDD family
I862_05485	COG1450	Type ii and iii secretion system protein
I862_05490	COG0148	phosphopyruvate hydratase activity
I862_05495	COG0148	phosphopyruvate hydratase activity
I862_05505	COG0736	holo-[acyl-carrier-protein] synthase activity
I862_05520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I862_05525	COG0477	Major facilitator Superfamily
I862_05540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I862_05560	COG1132	(ABC) transporter
I862_05565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I862_05585	COG0105	UTP biosynthetic process
I862_05590	COG0527	aspartate kinase activity
I862_05595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I862_05600	COG4520	surface antigen
I862_05610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I862_05615	COG0463	Glycosyl transferase, family 2
I862_05620	COG0237	dephospho-CoA kinase activity
I862_05625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I862_05640	COG1472	Belongs to the glycosyl hydrolase 3 family
I862_05650	COG0463	Glycosyl transferase, family 2
I862_05655	COG0477	Major facilitator Superfamily
I862_05660	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I862_05675	COG0326	Molecular chaperone. Has ATPase activity
I862_05690	COG0018	arginyl-trna synthetase
I862_05695	COG2271	Major facilitator Superfamily
I862_05710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I862_05715	COG2885	chlorophyll binding
I862_05720	COG0204	Acyl-transferase
I862_05745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I862_05755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I862_05770	COG0203	ribosomal protein L17
I862_05780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I862_05785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I862_05790	COG0563	adenylate kinase activity
I862_05795	COG0201	protein transport
I862_05805	COG1841	ribosomal large subunit assembly
I862_05820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I862_05825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I862_05830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I862_05835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I862_05840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I862_05855	COG0255	Belongs to the universal ribosomal protein uL29 family
I862_05860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I862_05865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I862_05870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I862_05875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I862_05880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I862_05885	COG0089	rRNA binding
I862_05890	COG0088	Forms part of the polypeptide exit tunnel
I862_05895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I862_05900	COG0051	transcription antitermination factor activity, RNA binding
I862_05905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I862_05920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I862_05925	COG1192	Involved in chromosome partitioning
I862_05930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I862_05935	COG3657	addiction module killer protein
I862_05940	COG0354	folic acid binding
I862_05960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I862_05965	COG0802	atpase or kinase
I862_05970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I862_05985	COG0598	Magnesium transport protein CorA
I862_05990	COG0359	binds to the 23S rRNA
I862_05995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I862_06000	COG0360	Binds together with S18 to 16S ribosomal RNA
I862_06005	COG0321	lipoyl(octanoyl) transferase activity
I862_06005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I862_06010	COG0084	hydrolase, TatD family'
I862_06015	COG0776	regulation of translation
I862_06025	COG0356	it plays a direct role in the translocation of protons across the membrane
I862_06030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I862_06040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I862_06045	COG0180	Tryptophanyl-tRNA synthetase
I862_06050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I862_06050	COG2857	Cytochrome c1
I862_06055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I862_06060	COG0670	Belongs to the BI1 family
I862_06065	COG3474	cytochrome
I862_06075	COG0330	HflC and HflK could
I862_06095	COG3278	Belongs to the heme-copper respiratory oxidase family
I862_06120	COG0776	regulation of translation
I862_06125	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I862_06135	COG0649	NAD binding
I862_06140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I862_06145	COG0758	DNA mediated transformation
I862_06155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I862_06165	COG1519	Transferase
I862_06170	COG1663	tetraacyldisaccharide 4'-kinase activity
I862_06175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I862_06180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I862_06185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I862_06190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I862_06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I862_06220	COG1028	Short-chain dehydrogenase reductase Sdr
I862_06240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I862_06245	COG0142	geranyltranstransferase activity
I862_06260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I862_06275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I862_06285	COG0316	Belongs to the HesB IscA family
I862_06290	COG0822	iron-sulfur transferase activity
I862_06300	COG1104	cysteine desulfurase activity
I862_06305	COG1959	2 iron, 2 sulfur cluster binding
I862_06310	COG2945	thiolester hydrolase activity
I862_06315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I862_06325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I862_06350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I862_06355	COG0750	zinc metalloprotease
I862_06360	COG0415	Belongs to the DNA photolyase family
I862_06365	COG0415	Belongs to the DNA photolyase family
I862_06385	COG2801	Transposase and inactivated derivatives
I862_06425	COG0564	pseudouridine synthase activity
I862_06430	COG1157	protein secretion by the type III secretion system
I862_06435	COG3088	subunit of a heme lyase
I862_06450	COG3202	ADP transmembrane transporter activity
I862_06455	COG1368	sulfuric ester hydrolase activity
I862_06475	COG3704	protein secretion by the type IV secretion system
I862_06480	COG3704	protein secretion by the type IV secretion system
I862_06490	COG3451	type IV secretory pathway VirB4
I862_06515	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I862_06520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I862_06530	COG5002	protein histidine kinase activity
I862_06565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I862_06605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I862_06615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I862_06620	COG1573	uracil-dna glycosylase
I862_06625	COG0196	riboflavin kinase activity
I862_06630	COG1674	ftsk spoiiie
I862_06635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I862_06640	COG0617	tRNA 3'-terminal CCA addition
I862_06645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I862_06655	COG0022	dehydrogenase e1 component
I862_06660	COG1132	(ABC) transporter
I862_06665	COG1252	NADH dehydrogenase
I862_06670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I862_06745	COG0488	(ABC) transporter
I862_06760	COG0217	transcriptional regulatory protein
I862_06765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I862_06770	COG0628	permease
I862_06775	COG3750	Belongs to the UPF0335 family
I862_06790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I862_06800	COG0174	glutamine synthetase
I862_06805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I862_06810	COG0741	lytic transglycosylase activity
I862_06825	COG0357	Ribosomal RNA small subunit methyltransferase G
I862_06830	COG1192	Involved in chromosome partitioning
I862_06835	COG1475	DNA binding
I862_06850	COG4496	protein, YerC YecD
I862_06880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I862_06885	COG0305	Participates in initiation and elongation during chromosome replication
I862_06910	COG2200	EAL domain
I862_06935	COG0024	Methionine aminopeptidase
I862_06945	COG0187	DNA topoisomerase II activity
I862_06955	COG0114	fumarate hydratase activity
I862_06960	COG0154	amidase activity
I862_06975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I862_06980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I862_06995	COG4942	peptidase
I862_06995	COG4942	peptidase
I862_07005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I862_07020	COG0149	triose-phosphate isomerase activity
I862_07045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I862_07050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I862_07070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I862_07075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I862_07080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I862_07085	COG1438	arginine binding
I862_07090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I862_07095	COG0765	amino acid transport
I862_07100	COG1126	abc transporter atp-binding protein
I862_07120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I862_07135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I862_07135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I862_07140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I862_07150	COG0751	glycine-tRNA ligase activity
I862_07165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I862_07205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I862_07215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I862_07220	COG2202	Pas domain
I862_07220	COG2205	protein histidine kinase activity
I862_07235	COG1138	Cytochrome C-type biogenesis protein
I862_07240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I862_07265	COG1696	Membrane protein involved in D-alanine export
I862_07340	COG2814	Major facilitator Superfamily
I862_07355	COG0666	response to abiotic stimulus
I862_07370	COG2337	Toxic component of a toxin-antitoxin (TA) module
I862_07425	COG1475	DNA binding
I862_07455	COG0666	response to abiotic stimulus
I862_07520	COG0653	protein targeting
I862_07535	COG4974	Belongs to the 'phage' integrase family
I862_07540	COG0666	response to abiotic stimulus
I862_07545	COG0443	Heat shock 70 kDa protein
I862_07560	COG0697	spore germination
I862_07600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I862_07605	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I862_07610	COG3494	Protein of unknown function (DUF1009)
I862_07620	COG0539	negative regulation of cytoplasmic translation
I862_07635	COG0308	aminopeptidase N
I862_07645	COG0484	heat shock protein binding