locus-tag	class	description
NARRFE1_00020	COG0187	DNA topoisomerase II activity
NARRFE1_00040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NARRFE1_00050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NARRFE1_00060	COG0539	negative regulation of cytoplasmic translation
NARRFE1_00080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NARRFE1_00100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NARRFE1_00110	COG0275	rRNA processing
NARRFE1_00120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NARRFE1_00130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NARRFE1_00160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NARRFE1_00170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NARRFE1_00190	COG0653	protein targeting
NARRFE1_00200	COG0459	protein refolding
NARRFE1_00210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NARRFE1_00230	COG0305	Participates in initiation and elongation during chromosome replication
NARRFE1_00240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NARRFE1_00260	COG0037	tRNA processing
NARRFE1_00290	COG0442	prolyl-tRNA aminoacylation
NARRFE1_00300	COG0513	Belongs to the DEAD box helicase family
NARRFE1_00310	COG1185	polyribonucleotide nucleotidyltransferase activity
NARRFE1_00320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NARRFE1_00340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NARRFE1_00360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NARRFE1_00370	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NARRFE1_00380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NARRFE1_00400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NARRFE1_00410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NARRFE1_00440	COG0084	hydrolase, TatD family'
NARRFE1_00450	COG0482	sulfurtransferase activity
NARRFE1_00480	COG0728	peptidoglycan biosynthetic process
NARRFE1_00490	COG0018	arginyl-trna synthetase
NARRFE1_00500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NARRFE1_00520	COG0740	serine-type endopeptidase activity
NARRFE1_00530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NARRFE1_00580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NARRFE1_00610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NARRFE1_00620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NARRFE1_00640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NARRFE1_00670	COG0716	FMN binding
NARRFE1_00680	COG0617	tRNA 3'-terminal CCA addition
NARRFE1_00690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NARRFE1_00700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NARRFE1_00710	COG0358	DNA primase activity
NARRFE1_00720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NARRFE1_00740	COG0525	valine-tRNA ligase activity
NARRFE1_00750	COG0017	Asparaginyl-tRNA synthetase
NARRFE1_00770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NARRFE1_00780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NARRFE1_00790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NARRFE1_00800	COG0180	Tryptophanyl-tRNA synthetase
NARRFE1_00810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NARRFE1_00820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NARRFE1_00830	COG0149	triose-phosphate isomerase activity
NARRFE1_00840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NARRFE1_00850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NARRFE1_00860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NARRFE1_00870	COG0254	rRNA binding
NARRFE1_00880	COG1530	ribonuclease E activity
NARRFE1_00910	COG0772	Belongs to the SEDS family
NARRFE1_00920	COG0768	penicillin binding
NARRFE1_00940	COG0495	leucyl-tRNA aminoacylation
NARRFE1_00950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NARRFE1_00960	COG0215	cysteine-tRNA ligase activity
NARRFE1_01000	COG0563	adenylate kinase activity
NARRFE1_01010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NARRFE1_01020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NARRFE1_01050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NARRFE1_01070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NARRFE1_01080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NARRFE1_01090	COG0124	histidyl-tRNA synthetase
NARRFE1_01130	COG1278	Cold shock
NARRFE1_01140	COG0587	DNA-directed DNA polymerase activity
NARRFE1_01160	COG0233	cytoplasmic translational termination
NARRFE1_01170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NARRFE1_01180	COG0052	Belongs to the universal ribosomal protein uS2 family
NARRFE1_01190	COG0024	Methionine aminopeptidase
NARRFE1_01230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NARRFE1_01240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NARRFE1_01250	COG0629	single-stranded DNA binding
NARRFE1_01270	COG1792	Involved in formation and maintenance of cell shape
NARRFE1_01280	COG1077	Cell shape determining protein MreB Mrl
NARRFE1_01320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NARRFE1_01330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NARRFE1_01340	COG0443	Heat shock 70 kDa protein
NARRFE1_01350	COG0484	heat shock protein binding
NARRFE1_01360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NARRFE1_01370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NARRFE1_01460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NARRFE1_01480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NARRFE1_01490	COG0222	ribosome binding
NARRFE1_01500	COG0085	RNA polymerase activity
NARRFE1_01510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NARRFE1_01530	COG0049	tRNA binding
NARRFE1_01540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NARRFE1_01560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NARRFE1_01590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NARRFE1_01600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NARRFE1_01610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NARRFE1_01650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NARRFE1_01660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NARRFE1_01670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NARRFE1_01680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NARRFE1_01700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NARRFE1_01710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NARRFE1_01730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NARRFE1_01740	COG0200	Binds to the 23S rRNA
NARRFE1_01750	COG0201	protein transport
NARRFE1_01760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NARRFE1_01770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NARRFE1_01780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NARRFE1_01790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NARRFE1_01800	COG0202	RNA polymerase activity
NARRFE1_01810	COG0203	ribosomal protein L17
NARRFE1_01850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NARRFE1_01870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NARRFE1_01880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NARRFE1_01880	COG0072	phenylalanine-tRNA ligase activity
NARRFE1_01890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NARRFE1_01910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NARRFE1_01920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NARRFE1_01930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NARRFE1_01950	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NARRFE1_01960	COG0739	heme binding
NARRFE1_01970	COG0752	glycyl-tRNA synthetase alpha subunit
NARRFE1_02000	COG0445	tRNA wobble uridine modification
NARRFE1_02010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NARRFE1_02020	COG0228	four-way junction DNA binding
NARRFE1_02030	COG0336	Belongs to the RNA methyltransferase TrmD family
NARRFE1_02040	COG0335	large ribosomal subunit rRNA binding
NARRFE1_02050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NARRFE1_02060	COG1605	Chorismate mutase
NARRFE1_02060	COG0287	Prephenate dehydrogenase
NARRFE1_02070	COG0564	pseudouridine synthase activity
NARRFE1_02110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NARRFE1_02120	COG2890	protein-(glutamine-N5) methyltransferase activity
NARRFE1_02130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NARRFE1_02140	COG0571	ribonuclease III activity
NARRFE1_02150	COG0681	Belongs to the peptidase S26 family
NARRFE1_02160	COG0481	GTPase activity
NARRFE1_02170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NARRFE1_02180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NARRFE1_02190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NARRFE1_02210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NARRFE1_02220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NARRFE1_02280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NARRFE1_02300	COG0230	Belongs to the bacterial ribosomal protein bL34 family