locus-tag	class	description
EBS_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBS_0002	COG0592	DNA-directed DNA polymerase activity
EBS_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBS_0004	COG0187	DNA topoisomerase II activity
EBS_0008	COG0751	glycine-tRNA ligase activity
EBS_0009	COG0752	glycyl-tRNA synthetase alpha subunit
EBS_0010	COG0482	sulfurtransferase activity
EBS_0015	COG1132	(ABC) transporter
EBS_0021	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EBS_0022	COG0174	glutamine synthetase
EBS_0023	COG3852	Histidine kinase
EBS_0029	COG0167	dihydroorotate dehydrogenase activity
EBS_0030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EBS_0031	COG0019	diaminopimelate decarboxylase activity
EBS_0032	COG2890	protein-(glutamine-N5) methyltransferase activity
EBS_0033	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EBS_0035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EBS_0037	COG3300	MHYT domain
EBS_0037	COG5001	Diguanylate cyclase
EBS_0038	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EBS_0039	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EBS_0041	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_0045	COG2226	methyltransferase
EBS_0047	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EBS_0050	COG2861	carbohydrate metabolic process
EBS_0051	COG0793	Belongs to the peptidase S41A family
EBS_0052	COG4942	peptidase
EBS_0053	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EBS_0056	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EBS_0065	COG0339	signal peptide processing
EBS_0067	COG1704	LemA family
EBS_0068	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EBS_0071	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EBS_0075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EBS_0077	COG1715	Restriction endonuclease
EBS_0086	COG0745	RESPONSE REGULATOR receiver
EBS_0086	COG2972	Histidine kinase
EBS_0087	COG0165	Argininosuccinate lyase
EBS_0090	COG3706	GGDEF domain
EBS_0090	COG0745	RESPONSE REGULATOR receiver
EBS_0092	COG4520	surface antigen
EBS_0093	COG0400	carboxylic ester hydrolase activity
EBS_0094	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EBS_0096	COG2959	enzyme of heme biosynthesis
EBS_0097	COG1587	Uroporphyrinogen-III synthase
EBS_0098	COG0181	hydroxymethylbilane synthase activity
EBS_0102	COG0408	coproporphyrinogen oxidase activity
EBS_0103	COG0009	L-threonylcarbamoyladenylate synthase
EBS_0105	COG2922	Belongs to the Smg family
EBS_0106	COG0758	DNA mediated transformation
EBS_0108	COG0242	peptide deformylase activity
EBS_0112	COG5000	phosphorelay sensor kinase activity
EBS_0113	COG2204	response regulator
EBS_0114	COG0569	domain protein
EBS_0116	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EBS_0120	COG0205	6-phosphofructokinase activity
EBS_0122	COG0563	adenylate kinase activity
EBS_0128	COG0513	Belongs to the DEAD box helicase family
EBS_0130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EBS_0131	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EBS_0135	COG2824	Alkylphosphonate utilization operon protein PhnA
EBS_0136	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EBS_0137	COG0321	lipoyl(octanoyl) transferase activity
EBS_0138	COG2921	Belongs to the UPF0250 family
EBS_0139	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBS_0140	COG1686	Belongs to the peptidase S11 family
EBS_0142	COG2951	lytic endotransglycosylase activity
EBS_0143	COG0772	Belongs to the SEDS family
EBS_0144	COG0768	penicillin binding
EBS_0145	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EBS_0146	COG1792	Involved in formation and maintenance of cell shape
EBS_0147	COG1077	Cell shape determining protein MreB Mrl
EBS_0148	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBS_0149	COG0154	amidase activity
EBS_0150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBS_0151	COG3706	GGDEF domain
EBS_0152	COG2813	Specifically methylates the guanine in position
EBS_0156	COG2890	protein-(glutamine-N5) methyltransferase activity
EBS_0157	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EBS_0158	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EBS_0161	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EBS_0162	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EBS_0163	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EBS_0164	COG0193	aminoacyl-tRNA hydrolase activity
EBS_0165	COG2409	Drug exporters of the RND superfamily
EBS_0169	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EBS_0170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EBS_0172	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EBS_0173	COG0081	regulation of translation
EBS_0174	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EBS_0175	COG0222	ribosome binding
EBS_0176	COG0085	RNA polymerase activity
EBS_0177	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EBS_0178	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EBS_0179	COG0049	tRNA binding
EBS_0180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EBS_0181	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EBS_0182	COG0051	transcription antitermination factor activity, RNA binding
EBS_0183	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EBS_0184	COG0088	Forms part of the polypeptide exit tunnel
EBS_0185	COG0089	rRNA binding
EBS_0186	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EBS_0187	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EBS_0188	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EBS_0189	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EBS_0190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EBS_0191	COG0255	Belongs to the universal ribosomal protein uL29 family
EBS_0192	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EBS_0193	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EBS_0194	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EBS_0195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EBS_0196	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EBS_0197	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EBS_0198	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EBS_0199	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EBS_0200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EBS_0202	COG0200	Binds to the 23S rRNA
EBS_0203	COG0201	protein transport
EBS_0204	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EBS_0205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EBS_0206	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EBS_0207	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EBS_0208	COG0202	RNA polymerase activity
EBS_0209	COG0203	ribosomal protein L17
EBS_0212	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EBS_0213	COG0432	Pfam Uncharacterised protein family UPF0047
EBS_0216	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EBS_0217	COG4535	Mg2 and Co2 transporter CorC
EBS_0218	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EBS_0219	COG1702	phosphate starvation-inducible protein PhoH
EBS_0220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBS_0222	COG0306	phosphate transporter
EBS_0226	COG2814	Major facilitator Superfamily
EBS_0228	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EBS_0229	COG3161	chorismate lyase activity
EBS_0230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EBS_0232	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EBS_0233	COG1040	competence protein
EBS_0235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EBS_0236	COG0156	8-amino-7-oxononanoate synthase activity
EBS_0237	COG0596	Alpha beta hydrolase
EBS_0238	COG2226	methyltransferase
EBS_0243	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EBS_0244	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EBS_0249	COG0109	protoheme IX farnesyltransferase activity
EBS_0250	COG3278	Belongs to the heme-copper respiratory oxidase family
EBS_0253	COG2010	Cytochrome c
EBS_0254	COG0348	domain, Protein
EBS_0257	COG2205	protein histidine kinase activity
EBS_0257	COG0784	Response regulator, receiver
EBS_0259	COG1538	Outer membrane efflux protein
EBS_0264	COG0653	protein targeting
EBS_0265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBS_0269	COG2177	Part of the ABC transporter FtsEX involved in
EBS_0270	COG2884	Cell division ATP-binding protein ftsE
EBS_0271	COG0552	protein localization to endoplasmic reticulum
EBS_0272	COG0612	Peptidase, M16
EBS_0273	COG0612	Peptidase, M16
EBS_0274	COG0742	ribosomal rna small subunit methyltransferase
EBS_0275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EBS_0276	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EBS_0283	COG1131	(ABC) transporter
EBS_0285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EBS_0287	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EBS_0288	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EBS_0289	COG0475	glutathione-regulated potassium exporter activity
EBS_0290	COG2003	Belongs to the UPF0758 family
EBS_0291	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EBS_0292	COG0756	dUTP diphosphatase activity
EBS_0294	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBS_0295	COG1309	transcriptional regulator
EBS_0297	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EBS_0298	COG0708	Exodeoxyribonuclease III
EBS_0303	COG1872	DUF167
EBS_0309	COG0543	2 iron, 2 sulfur cluster binding
EBS_0312	COG2020	methyltransferase activity
EBS_0313	COG0521	Mo-molybdopterin cofactor biosynthetic process
EBS_0314	COG0303	'Molybdopterin
EBS_0315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EBS_0316	COG0314	molybdopterin synthase activity
EBS_0322	COG0789	Transcriptional regulator
EBS_0324	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EBS_0324	COG0678	peroxiredoxin activity
EBS_0326	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EBS_0327	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBS_0329	COG3005	denitrification pathway
EBS_0334	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_0335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_0338	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_0340	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EBS_0341	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBS_0343	COG4133	protoheme IX ABC transporter activity
EBS_0344	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_0348	COG0512	Glutamine amidotransferase of anthranilate synthase
EBS_0349	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EBS_0350	COG0134	indole-3-glycerol-phosphate synthase activity
EBS_0353	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EBS_0354	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EBS_0355	COG2967	ApaG domain
EBS_0359	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EBS_0360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_0361	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EBS_0362	COG3178	'Phosphotransferase
EBS_0368	COG1242	4 iron, 4 sulfur cluster binding
EBS_0369	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EBS_0369	COG1328	CTP reductase activity
EBS_0373	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EBS_0380	COG0646	methionine synthase
EBS_0380	COG1410	methionine synthase
EBS_0381	COG0704	Plays a role in the regulation of phosphate uptake
EBS_0383	COG3706	GGDEF domain
EBS_0384	COG1643	Atp-dependent helicase
EBS_0389	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EBS_0396	COG2217	Heavy metal translocating P-type atpase
EBS_0400	COG3273	potassium ion transport
EBS_0400	COG0471	metal ion transport
EBS_0401	COG1444	tRNA N-acetyltransferase activity
EBS_0402	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EBS_0403	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EBS_0407	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EBS_0410	COG0754	glutathionylspermidine amidase activity
EBS_0411	COG1260	myo-inositol-1-phosphate synthase
EBS_0412	COG1213	nucleotidyl transferase
EBS_0412	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EBS_0414	COG3954	Phosphoribulokinase
EBS_0415	COG0277	FAD linked oxidase domain protein
EBS_0417	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EBS_0418	COG0792	nuclease activity
EBS_0419	COG3107	peptidoglycan biosynthetic process
EBS_0420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EBS_0422	COG2001	Belongs to the MraZ family
EBS_0423	COG0275	rRNA processing
EBS_0426	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EBS_0427	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EBS_0428	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBS_0429	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EBS_0430	COG0772	Belongs to the SEDS family
EBS_0431	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EBS_0432	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBS_0433	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EBS_0434	COG1181	Belongs to the D-alanine--D-alanine ligase family
EBS_0435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EBS_0437	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EBS_0438	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EBS_0440	COG0739	heme binding
EBS_0441	COG0653	protein targeting
EBS_0442	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EBS_0444	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EBS_0445	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EBS_0446	COG0237	dephospho-CoA kinase activity
EBS_0453	COG0542	response to heat
EBS_0454	COG0242	peptide deformylase activity
EBS_0457	COG0564	pseudouridine synthase activity
EBS_0461	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EBS_0462	COG0045	succinate-CoA ligase (ADP-forming) activity
EBS_0471	COG1120	ATPase activity
EBS_0472	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EBS_0474	COG0494	nUDIX hydrolase
EBS_0475	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EBS_0476	COG0069	glutamate synthase activity
EBS_0480	COG1714	RDD family
EBS_0489	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EBS_0491	COG4660	Part of a membrane complex involved in electron transport
EBS_0492	COG4659	FMN binding
EBS_0493	COG4658	electron transport chain
EBS_0495	COG2878	Part of a membrane complex involved in electron transport
EBS_0496	COG4657	Part of a membrane complex involved in electron transport
EBS_0499	COG1858	cytochrome C peroxidase
EBS_0500	COG5002	protein histidine kinase activity
EBS_0500	COG5001	Diguanylate cyclase
EBS_0501	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBS_0501	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBS_0502	COG0489	protein tyrosine kinase activity
EBS_0504	COG3842	ATPase activity
EBS_0505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EBS_0506	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EBS_0509	COG0367	asparagine synthase
EBS_0510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EBS_0512	COG2853	Lipoprotein
EBS_0518	COG1490	D-aminoacyl-tRNA deacylase activity
EBS_0519	COG0131	Imidazoleglycerol-phosphate dehydratase
EBS_0520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EBS_0521	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EBS_0522	COG0107	imidazoleglycerol-phosphate synthase activity
EBS_0523	COG0140	phosphoribosyl-ATP diphosphatase activity
EBS_0525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBS_0527	COG1331	Highly conserved protein containing a thioredoxin domain
EBS_0530	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EBS_0531	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EBS_0532	COG0358	DNA primase activity
EBS_0533	COG1610	YqeY-like protein
EBS_0534	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EBS_0536	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EBS_0539	COG1028	Short-chain dehydrogenase reductase Sdr
EBS_0546	COG1196	nuclear chromosome segregation
EBS_0546	COG0741	lytic transglycosylase activity
EBS_0546	COG0739	heme binding
EBS_0547	COG0483	inositol monophosphate 1-phosphatase activity
EBS_0548	COG0247	lactate metabolic process
EBS_0551	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EBS_0553	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBS_0555	COG0004	ammonium transporteR
EBS_0557	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBS_0558	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_0559	COG0596	Alpha beta hydrolase
EBS_0561	COG0142	geranyltranstransferase activity
EBS_0562	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EBS_0563	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EBS_0564	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EBS_0565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EBS_0567	COG0840	transmembrane signaling receptor activity
EBS_0568	COG0268	Binds directly to 16S ribosomal RNA
EBS_0569	COG0728	peptidoglycan biosynthetic process
EBS_0570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EBS_0571	COG0196	riboflavin kinase activity
EBS_0572	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EBS_0573	COG0529	Catalyzes the synthesis of activated sulfate
EBS_0574	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EBS_0575	COG3023	N-Acetylmuramoyl-L-alanine amidase
EBS_0583	COG1047	Peptidyl-prolyl cis-trans
EBS_0585	COG0271	Belongs to the BolA IbaG family
EBS_0587	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBS_0588	COG0567	Dehydrogenase, E1 component
EBS_0591	COG3706	GGDEF domain
EBS_0599	COG0835	chemotaxis
EBS_0599	COG0784	Response regulator, receiver
EBS_0600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EBS_0601	COG1815	bacterial-type flagellum-dependent cell motility
EBS_0602	COG1558	bacterial-type flagellum-dependent cell motility
EBS_0603	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EBS_0604	COG1749	Flagellar hook protein flgE
EBS_0605	COG4786	Flagellar basal body rod
EBS_0607	COG4786	Flagellar basal body rod
EBS_0608	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EBS_0611	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EBS_0620	COG2827	Endonuclease containing a URI domain
EBS_0625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EBS_0628	COG2815	serine threonine protein kinase
EBS_0628	COG0515	serine threonine protein kinase
EBS_0629	COG2920	part of a sulfur-relay system
EBS_0630	COG2223	nitrite transmembrane transporter activity
EBS_0631	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EBS_0633	COG0243	molybdopterin cofactor binding
EBS_0634	COG0437	4 iron, 4 sulfur cluster binding
EBS_0635	COG0318	PFAM AMP-dependent synthetase and ligase
EBS_0637	COG1441	menaquinone biosynthetic process
EBS_0642	COG1575	Belongs to the MenA family. Type 1 subfamily
EBS_0643	COG0243	molybdopterin cofactor binding
EBS_0644	COG1763	Mo-molybdopterin cofactor biosynthetic process
EBS_0649	COG0659	secondary active sulfate transmembrane transporter activity
EBS_0650	COG1047	Peptidyl-prolyl cis-trans
EBS_0653	COG4206	TonB-dependent receptor
EBS_0659	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EBS_0660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBS_0661	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EBS_0667	COG0489	protein tyrosine kinase activity
EBS_0668	COG4464	protein tyrosine phosphatase activity
EBS_0671	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EBS_0681	COG0735	belongs to the Fur family
EBS_0682	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EBS_0683	COG1121	(ABC) transporter
EBS_0685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EBS_0686	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EBS_0687	COG0659	secondary active sulfate transmembrane transporter activity
EBS_0688	COG1278	Cold shock
EBS_0689	COG0724	RNA recognition motif
EBS_0699	COG1850	ribulose-bisphosphate carboxylase activity
EBS_0703	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EBS_0704	COG0537	adenosine 5'-monophosphoramidase activity
EBS_0706	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EBS_0707	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBS_0708	COG1393	Belongs to the ArsC family
EBS_0709	COG2171	N-acyltransferase activity
EBS_0710	COG0436	Aminotransferase
EBS_0713	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EBS_0714	COG0024	Methionine aminopeptidase
EBS_0715	COG0052	Belongs to the universal ribosomal protein uS2 family
EBS_0716	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EBS_0717	COG0528	UMP kinase activity
EBS_0718	COG0233	cytoplasmic translational termination
EBS_0720	COG0575	Belongs to the CDS family
EBS_0721	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EBS_0722	COG0750	zinc metalloprotease
EBS_0725	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_0726	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBS_0727	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_0728	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_0729	COG1355	regulation of microtubule-based process
EBS_0730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EBS_0734	COG0717	Belongs to the dCTP deaminase family
EBS_0735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EBS_0736	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EBS_0738	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EBS_0739	COG0628	permease
EBS_0740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBS_0743	COG1393	Belongs to the ArsC family
EBS_0746	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_0750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EBS_0753	COG1592	Rubrerythrin
EBS_0756	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBS_0757	COG2205	protein histidine kinase activity
EBS_0758	COG3706	GGDEF domain
EBS_0758	COG0745	RESPONSE REGULATOR receiver
EBS_0759	COG0442	prolyl-tRNA aminoacylation
EBS_0762	COG0488	(ABC) transporter
EBS_0763	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EBS_0765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EBS_0766	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EBS_0767	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBS_0767	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBS_0770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EBS_0771	COG1309	transcriptional regulator
EBS_0772	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBS_0774	COG1136	(ABC) transporter
EBS_0778	COG0142	geranyltranstransferase activity
EBS_0779	COG1722	exodeoxyribonuclease VII activity
EBS_0785	COG5001	Diguanylate cyclase
EBS_0785	COG5002	protein histidine kinase activity
EBS_0790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EBS_0795	COG1199	ATP-dependent helicase activity
EBS_0802	COG1214	PFAM Peptidase M22, glycoprotease
EBS_0806	COG2833	Protein of unknown function (DUF455)
EBS_0808	COG0688	phosphatidylethanolamine metabolic process
EBS_0809	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBS_0811	COG2205	protein histidine kinase activity
EBS_0812	COG0745	RESPONSE REGULATOR receiver
EBS_0817	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBS_0823	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EBS_0824	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EBS_0825	COG0308	aminopeptidase N
EBS_0826	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
EBS_0827	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EBS_0830	COG5265	(ABC) transporter
EBS_0831	COG0617	tRNA 3'-terminal CCA addition
EBS_0832	COG3850	Histidine kinase
EBS_0833	COG2197	response regulator
EBS_0837	COG0215	cysteine-tRNA ligase activity
EBS_0840	COG1162	GTPase activity
EBS_0843	COG3706	GGDEF domain
EBS_0843	COG2203	Gaf domain
EBS_0843	COG4251	negative regulation of phosphorylation
EBS_0843	COG5001	Diguanylate cyclase
EBS_0844	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EBS_0846	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EBS_0846	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EBS_0847	COG0802	atpase or kinase
EBS_0848	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBS_0850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EBS_0851	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBS_0852	COG1923	regulation of RNA biosynthetic process
EBS_0853	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EBS_0854	COG0330	HflC and HflK could
EBS_0855	COG0330	HflC and HflK could
EBS_0856	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EBS_0857	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EBS_0860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBS_0861	COG0071	Belongs to the small heat shock protein (HSP20) family
EBS_0863	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EBS_0864	COG1940	carbohydrate kinase activity
EBS_0874	COG1509	lysine 2,3-aminomutase activity
EBS_0875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EBS_0880	COG1648	precorrin-2 dehydrogenase activity
EBS_0880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBS_0881	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBS_0882	COG0425	Belongs to the sulfur carrier protein TusA family
EBS_0883	COG2210	Belongs to the sulfur carrier protein TusA family
EBS_0885	COG0583	DNA-binding transcription factor activity
EBS_0891	COG2205	protein histidine kinase activity
EBS_0891	COG0784	Response regulator, receiver
EBS_0891	COG5002	protein histidine kinase activity
EBS_0892	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EBS_0894	COG2716	regulation of RNA biosynthetic process
EBS_0897	COG2169	Transcriptional regulator
EBS_0897	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EBS_0905	COG0243	molybdopterin cofactor binding
EBS_0906	COG0437	4 iron, 4 sulfur cluster binding
EBS_0907	COG3302	dmso reductase anchor subunit
EBS_0913	COG2983	Belongs to the UPF0260 family
EBS_0915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EBS_0916	COG0631	protein serine/threonine phosphatase activity
EBS_0919	COG0525	valine-tRNA ligase activity
EBS_0922	COG0737	Belongs to the 5'-nucleotidase family
EBS_0923	COG0247	lactate metabolic process
EBS_0924	COG0277	FAD linked oxidase domain protein
EBS_0925	COG0277	FAD linked oxidase domain protein
EBS_0926	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EBS_0928	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EBS_0931	COG1414	Transcriptional regulator
EBS_0932	COG0513	Belongs to the DEAD box helicase family
EBS_0933	COG2814	Major facilitator Superfamily
EBS_0934	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EBS_0935	COG0471	metal ion transport
EBS_0935	COG3273	potassium ion transport
EBS_0937	COG2920	part of a sulfur-relay system
EBS_0939	COG0564	pseudouridine synthase activity
EBS_0941	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EBS_0948	COG0489	protein tyrosine kinase activity
EBS_0954	COG2132	Multicopper oxidase
EBS_0956	COG0438	transferase activity, transferring glycosyl groups
EBS_0956	COG0297	glycogen (starch) synthase activity
EBS_0957	COG0535	radical SAM domain protein
EBS_0960	COG3267	Type II secretory pathway component ExeA
EBS_0960	COG3409	Peptidoglycan-binding domain 1 protein
EBS_0963	COG1959	2 iron, 2 sulfur cluster binding
EBS_0964	COG1104	cysteine desulfurase activity
EBS_0965	COG0724	RNA recognition motif
EBS_0968	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EBS_0970	COG0633	Ferredoxin
EBS_0973	COG0105	UTP biosynthetic process
EBS_0974	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EBS_0976	COG1426	Protein conserved in bacteria
EBS_0977	COG0124	histidyl-tRNA synthetase
EBS_0978	COG2976	Protein conserved in bacteria
EBS_0980	COG1160	GTP binding
EBS_0982	COG2974	May be involved in recombination
EBS_0983	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EBS_0985	COG1760	l-serine dehydratase
EBS_0986	COG0303	'Molybdopterin
EBS_0987	COG1763	Mo-molybdopterin cofactor biosynthetic process
EBS_0988	COG0746	molybdenum cofactor guanylyltransferase activity
EBS_0989	COG3842	ATPase activity
EBS_0990	COG4662	Binding-protein-dependent transport system inner membrane component
EBS_0997	COG1902	pentaerythritol trinitrate reductase activity
EBS_0998	COG2814	Major facilitator Superfamily
EBS_1004	COG0557	exoribonuclease II activity
EBS_1005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBS_1006	COG0360	Binds together with S18 to 16S ribosomal RNA
EBS_1007	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EBS_1009	COG0359	binds to the 23S rRNA
EBS_1010	COG0305	Participates in initiation and elongation during chromosome replication
EBS_1011	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EBS_1014	COG4536	flavin adenine dinucleotide binding
EBS_1015	COG2204	response regulator
EBS_1016	COG3852	Histidine kinase
EBS_1020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EBS_1026	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EBS_1027	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EBS_1030	COG0426	domain, Protein
EBS_1030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EBS_1031	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_1033	COG1959	2 iron, 2 sulfur cluster binding
EBS_1035	COG4191	Histidine kinase
EBS_1040	COG0318	PFAM AMP-dependent synthetase and ligase
EBS_1041	COG0398	Pfam SNARE associated Golgi protein
EBS_1043	COG0640	Transcriptional regulator
EBS_1045	COG2226	methyltransferase
EBS_1049	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EBS_1050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EBS_1051	COG1605	Chorismate mutase
EBS_1051	COG0077	Prephenate dehydratase
EBS_1052	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EBS_1053	COG0287	Prephenate dehydrogenase
EBS_1057	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBS_1064	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EBS_1065	COG0733	neurotransmitter:sodium symporter activity
EBS_1066	COG2867	negative regulation of translational initiation
EBS_1067	COG2914	Belongs to the UPF0125 (RnfH) family
EBS_1068	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBS_1069	COG0735	belongs to the Fur family
EBS_1074	COG0497	DNA recombination
EBS_1075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EBS_1076	COG1420	regulation of RNA biosynthetic process
EBS_1077	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EBS_1078	COG0443	Heat shock 70 kDa protein
EBS_1079	COG0484	heat shock protein binding
EBS_1080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EBS_1084	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EBS_1085	COG0284	orotidine-5'-phosphate decarboxylase activity
EBS_1086	COG2046	Belongs to the sulfate adenylyltransferase family
EBS_1090	COG2850	peptidyl-arginine hydroxylation
EBS_1095	COG0482	sulfurtransferase activity
EBS_1097	COG0670	Belongs to the BI1 family
EBS_1101	COG5001	Diguanylate cyclase
EBS_1101	COG5002	protein histidine kinase activity
EBS_1105	COG2197	response regulator
EBS_1106	COG1573	uracil-dna glycosylase
EBS_1107	COG0322	excinuclease ABC activity
EBS_1121	COG2346	COG2346, Truncated hemoglobins
EBS_1122	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBS_1123	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EBS_1124	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EBS_1125	COG0436	Aminotransferase
EBS_1126	COG1230	cation diffusion facilitator family transporter
EBS_1127	COG0826	peptidase U32
EBS_1131	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBS_1132	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBS_1137	COG0318	PFAM AMP-dependent synthetase and ligase
EBS_1140	COG0658	competence protein
EBS_1140	COG2333	competence protein COMEC
EBS_1141	COG0811	peptide transport
EBS_1142	COG0848	biopolymer transport protein
EBS_1143	COG1663	tetraacyldisaccharide 4'-kinase activity
EBS_1144	COG2835	tetraacyldisaccharide 4'-kinase activity
EBS_1146	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBS_1149	COG0546	phosphoglycolate phosphatase activity
EBS_1154	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EBS_1156	COG1607	acyl-coa hydrolase
EBS_1159	COG4251	negative regulation of phosphorylation
EBS_1159	COG3706	GGDEF domain
EBS_1159	COG5001	Diguanylate cyclase
EBS_1159	COG2203	Gaf domain
EBS_1164	COG1472	Belongs to the glycosyl hydrolase 3 family
EBS_1169	COG0747	negative chemotaxis
EBS_1174	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EBS_1177	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EBS_1178	COG1381	Involved in DNA repair and RecF pathway recombination
EBS_1183	COG0481	GTPase activity
EBS_1185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBS_1189	COG1595	DNA-templated transcription, initiation
EBS_1191	COG0084	hydrolase, TatD family'
EBS_1195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EBS_1196	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBS_1197	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EBS_1198	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBS_1200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EBS_1201	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBS_1202	COG0416	fatty acid biosynthetic process
EBS_1203	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EBS_1208	COG0424	maF-like protein
EBS_1209	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EBS_1211	COG1254	Belongs to the acylphosphatase family
EBS_1213	COG0583	DNA-binding transcription factor activity
EBS_1217	COG1286	toxin biosynthetic process
EBS_1221	COG0285	dihydrofolate synthase activity
EBS_1222	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EBS_1223	COG0159	tryptophan synthase activity
EBS_1224	COG0133	tryptophan synthase activity
EBS_1225	COG0135	phosphoribosylanthranilate isomerase activity
EBS_1226	COG0101	tRNA pseudouridine synthase activity
EBS_1229	COG0473	3-isopropylmalate dehydrogenase activity
EBS_1230	COG0066	3-isopropylmalate dehydratase activity
EBS_1231	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EBS_1237	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EBS_1240	COG3706	GGDEF domain
EBS_1243	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EBS_1245	COG0180	Tryptophanyl-tRNA synthetase
EBS_1246	COG1994	Peptidase M50
EBS_1247	COG0009	L-threonylcarbamoyladenylate synthase
EBS_1248	COG0613	PHP domain protein
EBS_1253	COG2917	probably involved in intracellular septation
EBS_1254	COG2350	Protein conserved in bacteria
EBS_1255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_1260	COG1238	metal cluster binding
EBS_1261	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBS_1262	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EBS_1266	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EBS_1270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EBS_1272	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EBS_1273	COG2009	succinate dehydrogenase
EBS_1277	COG1968	undecaprenyl-diphosphatase activity
EBS_1281	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_1283	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EBS_1285	COG0500	methyltransferase
EBS_1290	COG4974	Belongs to the 'phage' integrase family
EBS_1295	COG0776	regulation of translation
EBS_1296	COG0072	phenylalanine-tRNA ligase activity
EBS_1297	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EBS_1298	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EBS_1299	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EBS_1300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EBS_1301	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EBS_1302	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBS_1307	COG2801	Transposase and inactivated derivatives
EBS_1311	COG0402	S-adenosylhomocysteine deaminase activity
EBS_1317	COG1028	Short-chain dehydrogenase reductase Sdr
EBS_1318	COG0463	Glycosyl transferase, family 2
EBS_1319	COG1538	Outer membrane efflux protein
EBS_1320	COG0739	heme binding
EBS_1321	COG1132	(ABC) transporter
EBS_1322	COG0429	hydrolase of the alpha beta-hydrolase fold
EBS_1328	COG3012	SEC-C Motif Domain Protein
EBS_1334	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EBS_1335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EBS_1336	COG0148	phosphopyruvate hydratase activity
EBS_1337	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EBS_1338	COG0504	CTP synthase activity
EBS_1340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_1341	COG3278	Belongs to the heme-copper respiratory oxidase family
EBS_1344	COG2010	Cytochrome c
EBS_1348	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EBS_1349	COG0328	RNA-DNA hybrid ribonuclease activity
EBS_1350	COG2226	methyltransferase
EBS_1353	COG4172	Belongs to the ABC transporter superfamily
EBS_1355	COG0601	transmembrane transport
EBS_1356	COG4166	transmembrane transport
EBS_1359	COG1215	transferase activity, transferring glycosyl groups
EBS_1363	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EBS_1364	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EBS_1365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EBS_1371	COG0511	ligase activity, forming carbon-carbon bonds
EBS_1371	COG5016	pyruvate
EBS_1372	COG0439	Biotin carboxylase
EBS_1373	COG0585	pseudouridine synthase activity
EBS_1374	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EBS_1375	COG0084	hydrolase, TatD family'
EBS_1376	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EBS_1378	COG0647	UMP catabolic process
EBS_1382	COG2205	protein histidine kinase activity
EBS_1390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_1392	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EBS_1393	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EBS_1394	COG0740	serine-type endopeptidase activity
EBS_1395	COG0544	peptidyl-prolyl cis-trans isomerase activity
EBS_1397	COG0776	regulation of translation
EBS_1400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EBS_1402	COG0590	tRNA wobble adenosine to inosine editing
EBS_1403	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EBS_1403	COG0519	Catalyzes the synthesis of GMP from XMP
EBS_1405	COG0563	adenylate kinase activity
EBS_1406	COG0563	adenylate kinase activity
EBS_1409	COG0583	DNA-binding transcription factor activity
EBS_1410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EBS_1415	COG0326	Molecular chaperone. Has ATPase activity
EBS_1418	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EBS_1419	COG0527	aspartate kinase activity
EBS_1420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EBS_1425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EBS_1426	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_1429	COG0557	exoribonuclease II activity
EBS_1433	COG0668	transmembrane transport
EBS_1434	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EBS_1435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EBS_1437	COG0617	tRNA 3'-terminal CCA addition
EBS_1442	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EBS_1443	COG2995	paraquat-inducible protein a
EBS_1444	COG0037	tRNA processing
EBS_1445	COG0825	malonyl-CoA metabolic process
EBS_1446	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EBS_1450	COG1074	ATP-dependent DNA helicase activity
EBS_1451	COG0259	pyridoxamine-phosphate oxidase activity
EBS_1458	COG2137	regulation of response to DNA damage stimulus
EBS_1463	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EBS_1464	COG0033	Phosphoglucomutase
EBS_1466	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EBS_1467	COG0277	FAD linked oxidase domain protein
EBS_1468	COG0277	FAD linked oxidase domain protein
EBS_1470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_1471	COG4566	intracellular signal transduction
EBS_1472	COG4191	Histidine kinase
EBS_1475	COG0795	lipopolysaccharide-transporting ATPase activity
EBS_1477	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBS_1480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EBS_1483	COG0463	Glycosyl transferase, family 2
EBS_1484	COG1185	polyribonucleotide nucleotidyltransferase activity
EBS_1485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EBS_1486	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EBS_1487	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EBS_1488	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EBS_1489	COG0195	Participates in both transcription termination and antitermination
EBS_1489	COG2251	uridine kinase activity
EBS_1491	COG1007	ATP synthesis coupled electron transport
EBS_1494	COG0713	ATP synthesis coupled electron transport
EBS_1496	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_1497	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EBS_1498	COG1034	ATP synthesis coupled electron transport
EBS_1500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EBS_1501	COG0649	NAD binding
EBS_1502	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_1503	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_1504	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_1506	COG0149	triose-phosphate isomerase activity
EBS_1507	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBS_1508	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EBS_1509	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EBS_1510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EBS_1511	COG1534	Rna-binding protein
EBS_1512	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBS_1514	COG0505	Belongs to the CarA family
EBS_1515	COG3118	belongs to the thioredoxin family
EBS_1516	COG3118	belongs to the thioredoxin family
EBS_1517	COG1720	tRNA m6t6A37 methyltransferase activity
EBS_1523	COG1126	abc transporter atp-binding protein
EBS_1524	COG0765	amino acid transport
EBS_1525	COG4597	amino acid ABC transporter
EBS_1526	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EBS_1528	COG1136	(ABC) transporter
EBS_1529	COG4591	ABC-type transport system involved in lipoprotein release permease component
EBS_1531	COG2957	Belongs to the agmatine deiminase family
EBS_1532	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBS_1541	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EBS_1543	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EBS_1544	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EBS_1545	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EBS_1546	COG1674	ftsk spoiiie
EBS_1547	COG0686	Belongs to the AlaDH PNT family
EBS_1548	COG0492	ferredoxin-NADP+ reductase activity
EBS_1551	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EBS_1552	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EBS_1553	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EBS_1554	COG0542	response to heat
EBS_1555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EBS_1556	COG1278	Cold shock
EBS_1559	COG2204	response regulator
EBS_1561	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EBS_1571	COG2010	Cytochrome c
EBS_1572	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_1580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBS_1580	COG1648	precorrin-2 dehydrogenase activity
EBS_1587	COG2132	Multicopper oxidase
EBS_1589	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EBS_1591	COG1196	nuclear chromosome segregation
EBS_1592	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EBS_1593	COG1070	Carbohydrate kinase
EBS_1599	COG0436	Aminotransferase
EBS_1601	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EBS_1602	COG0166	Belongs to the GPI family
EBS_1603	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EBS_1610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EBS_1610	COG2885	chlorophyll binding
EBS_1612	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EBS_1613	COG0204	Acyl-transferase
EBS_1615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EBS_1616	COG0750	zinc metalloprotease
EBS_1618	COG1469	GTP cyclohydrolase I activity
EBS_1620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EBS_1622	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EBS_1623	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EBS_1634	COG4783	chaperone-mediated protein folding
EBS_1646	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EBS_1648	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBS_1649	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EBS_1655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EBS_1656	COG0602	queuosine metabolic process
EBS_1658	COG2885	chlorophyll binding
EBS_1659	COG0823	Involved in the tonB-independent uptake of proteins
EBS_1661	COG0848	biopolymer transport protein
EBS_1662	COG0811	peptide transport
EBS_1663	COG0824	Thioesterase
EBS_1664	COG2255	four-way junction helicase activity
EBS_1665	COG0632	four-way junction helicase activity
EBS_1666	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EBS_1671	COG5001	Diguanylate cyclase
EBS_1671	COG5002	protein histidine kinase activity
EBS_1672	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EBS_1676	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EBS_1679	COG0793	Belongs to the peptidase S41A family
EBS_1682	COG3956	TIGRFAM MazG family protein
EBS_1683	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EBS_1690	COG0410	ABC transporter
EBS_1693	COG0559	Belongs to the binding-protein-dependent transport system permease family
EBS_1697	COG0129	dihydroxy-acid dehydratase activity
EBS_1698	COG5001	Diguanylate cyclase
EBS_1698	COG5002	protein histidine kinase activity
EBS_1701	COG1309	transcriptional regulator
EBS_1705	COG0330	HflC and HflK could
EBS_1706	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EBS_1706	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBS_1708	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBS_1710	COG0183	Belongs to the thiolase family
EBS_1711	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBS_1713	COG0668	transmembrane transport
EBS_1716	COG0835	chemotaxis
EBS_1717	COG1192	Involved in chromosome partitioning
EBS_1718	COG1360	Flagellar Motor Protein
EBS_1719	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EBS_1720	COG2201	protein-glutamate methylesterase activity
EBS_1721	COG0643	Histidine kinase
EBS_1721	COG2198	Histidine kinase
EBS_1722	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EBS_1725	COG0455	bacterial-type flagellum organization
EBS_1727	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EBS_1729	COG1684	flagellar biosynthetic protein fliR
EBS_1730	COG1987	bacterial-type flagellum assembly
EBS_1732	COG3190	flagellar
EBS_1738	COG2270	Major facilitator Superfamily
EBS_1739	COG0842	Transport permease protein
EBS_1740	COG1131	(ABC) transporter
EBS_1744	COG0456	acetyltransferase
EBS_1745	COG1573	uracil-dna glycosylase
EBS_1746	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EBS_1747	COG1183	phosphatidylcholine synthase activity
EBS_1748	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EBS_1749	COG0440	acetolactate synthase activity
EBS_1750	COG0028	Belongs to the TPP enzyme family
EBS_1752	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBS_1753	COG1322	Protein conserved in bacteria
EBS_1758	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EBS_1759	COG0071	Belongs to the small heat shock protein (HSP20) family
EBS_1761	COG1509	lysine 2,3-aminomutase activity
EBS_1764	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBS_1767	COG5002	protein histidine kinase activity
EBS_1767	COG0784	Response regulator, receiver
EBS_1767	COG2205	protein histidine kinase activity
EBS_1769	COG0708	Exodeoxyribonuclease III
EBS_1772	COG1797	cobyrinic acid a,c-diamide synthase activity
EBS_1779	COG2920	part of a sulfur-relay system
EBS_1781	COG2923	Belongs to the DsrF TusC family
EBS_1782	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EBS_1783	COG2221	Nitrite and sulphite reductase 4Fe-4S
EBS_1784	COG2221	Nitrite and sulphite reductase 4Fe-4S
EBS_1793	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EBS_1803	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBS_1804	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EBS_1807	COG5007	Belongs to the BolA IbaG family
EBS_1808	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EBS_1811	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBS_1812	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBS_1813	COG1862	Preprotein translocase
EBS_1814	COG0343	queuine tRNA-ribosyltransferase activity
EBS_1815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EBS_1818	COG0134	indole-3-glycerol-phosphate synthase activity
EBS_1819	COG0135	phosphoribosylanthranilate isomerase activity
EBS_1820	COG1538	Outer membrane efflux protein
EBS_1822	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EBS_1823	COG2900	Belongs to the SlyX family
EBS_1824	COG0047	phosphoribosylformylglycinamidine synthase activity
EBS_1824	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EBS_1825	COG0840	transmembrane signaling receptor activity
EBS_1826	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EBS_1827	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EBS_1828	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBS_1830	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EBS_1831	COG0446	pyridine nucleotide-disulphide oxidoreductase
EBS_1835	COG0697	spore germination
EBS_1836	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBS_1844	COG2925	Exonuclease
EBS_1845	COG0335	large ribosomal subunit rRNA binding
EBS_1846	COG0336	Belongs to the RNA methyltransferase TrmD family
EBS_1847	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EBS_1848	COG0228	four-way junction DNA binding
EBS_1851	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EBS_1860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EBS_1867	COG0137	argininosuccinate synthase activity
EBS_1870	COG1136	(ABC) transporter
EBS_1870	COG0577	efflux transmembrane transporter activity
EBS_1871	COG1136	(ABC) transporter
EBS_1871	COG0577	efflux transmembrane transporter activity
EBS_1876	COG0840	transmembrane signaling receptor activity
EBS_1878	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EBS_1881	COG0191	fructose-bisphosphate aldolase activity
EBS_1883	COG0126	phosphoglycerate kinase activity
EBS_1884	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EBS_1885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EBS_1889	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EBS_1890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EBS_1891	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EBS_1893	COG0643	Histidine kinase
EBS_1893	COG2198	Histidine kinase
EBS_1894	COG0840	transmembrane signaling receptor activity
EBS_1902	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EBS_1903	COG1678	Uncharacterized ACR, COG1678
EBS_1904	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EBS_1906	COG0540	Belongs to the ATCase OTCase family
EBS_1910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBS_1911	COG2832	Protein of unknown function (DUF454)
EBS_1912	COG0501	Belongs to the peptidase M48B family
EBS_1914	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EBS_1916	COG3706	GGDEF domain
EBS_1922	COG1187	pseudouridine synthase activity
EBS_1924	COG0247	lactate metabolic process
EBS_1930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBS_1931	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBS_1932	COG1519	Transferase
EBS_1933	COG1560	Kdo2-lipid A biosynthetic process
EBS_1935	COG1132	(ABC) transporter
EBS_1938	COG2755	lipolytic protein G-D-S-L family
EBS_1938	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EBS_1947	COG0463	Glycosyl transferase, family 2
EBS_1950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EBS_1951	COG0438	transferase activity, transferring glycosyl groups
EBS_1953	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EBS_1956	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EBS_1959	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EBS_1962	COG1324	tolerance protein
EBS_1963	COG4232	protein-disulfide reductase activity
EBS_1964	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_1965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EBS_1966	COG0511	ligase activity, forming carbon-carbon bonds
EBS_1967	COG0439	Biotin carboxylase
EBS_1968	COG2264	protein methyltransferase activity
EBS_1972	COG0138	bifunctional purine biosynthesis protein purh
EBS_1977	COG4221	oxidoreductase activity
EBS_1979	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBS_1984	COG5001	Diguanylate cyclase
EBS_1984	COG3300	MHYT domain
EBS_1985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_1986	COG0151	Belongs to the GarS family
EBS_1988	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EBS_1989	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EBS_1991	COG1573	uracil-dna glycosylase
EBS_1992	COG3321	synthase
EBS_1992	COG1028	Short-chain dehydrogenase reductase Sdr
EBS_1992	COG0604	alcohol dehydrogenase
EBS_1993	COG0037	tRNA processing
EBS_1995	COG0840	transmembrane signaling receptor activity
EBS_1996	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EBS_1998	COG0288	reversible hydration of carbon dioxide
EBS_2003	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_2009	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EBS_2012	COG3850	Histidine kinase
EBS_2012	COG4999	Histidine kinase
EBS_2012	COG2205	protein histidine kinase activity
EBS_2012	COG3437	response regulator, receiver
EBS_2014	COG0012	GTP binding
EBS_2016	COG0840	transmembrane signaling receptor activity
EBS_2017	COG2201	protein-glutamate methylesterase activity
EBS_2018	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EBS_2022	COG1192	Involved in chromosome partitioning
EBS_2023	COG0835	chemotaxis
EBS_2025	COG0840	transmembrane signaling receptor activity
EBS_2026	COG2198	Histidine kinase
EBS_2026	COG0643	Histidine kinase
EBS_2030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EBS_2034	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EBS_2035	COG0739	heme binding
EBS_2036	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EBS_2037	COG0316	Belongs to the HesB IscA family
EBS_2040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EBS_2045	COG0316	Belongs to the HesB IscA family
EBS_2047	COG1773	rubredoxin
EBS_2048	COG0351	phosphomethylpyrimidine kinase
EBS_2049	COG0352	thiamine-phosphate diphosphorylase activity
EBS_2050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EBS_2051	COG0586	Pfam SNARE associated Golgi protein
EBS_2052	COG0406	alpha-ribazole phosphatase activity
EBS_2055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EBS_2056	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBS_2057	COG1758	RNA polymerase activity
EBS_2058	COG0194	GDP metabolic process
EBS_2059	COG1561	YicC-like family, N-terminal region
EBS_2060	COG0515	serine threonine protein kinase
EBS_2062	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EBS_2063	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EBS_2066	COG2084	Dehydrogenase
EBS_2071	COG0546	phosphoglycolate phosphatase activity
EBS_2075	COG0018	arginyl-trna synthetase
EBS_2076	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EBS_2084	COG0789	Transcriptional regulator
EBS_2088	COG0004	ammonium transporteR
EBS_2089	COG0347	Belongs to the P(II) protein family
EBS_2091	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EBS_2102	COG5002	protein histidine kinase activity
EBS_2105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EBS_2107	COG0573	inorganic phosphate transmembrane transporter activity
EBS_2109	COG0488	(ABC) transporter
EBS_2112	COG1881	PFAM PEBP family protein
EBS_2113	COG2133	pyrroloquinoline quinone binding
EBS_2114	COG0459	protein refolding
EBS_2115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EBS_2120	COG1454	alcohol dehydrogenase
EBS_2123	COG3100	YcgL domain-containing protein
EBS_2124	COG0560	Phosphoserine phosphatase
EBS_2124	COG3830	Belongs to the UPF0237 family
EBS_2131	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EBS_2138	COG3577	Aspartyl protease
EBS_2142	COG1233	COG1233 Phytoene dehydrogenase and related
EBS_2143	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_2145	COG2048	Heterodisulfide reductase, subunit B
EBS_2150	COG2204	response regulator
EBS_2151	COG1595	DNA-templated transcription, initiation
EBS_2152	COG1166	arginine decarboxylase activity
EBS_2153	COG0583	DNA-binding transcription factor activity
EBS_2154	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EBS_2158	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EBS_2161	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EBS_2162	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EBS_2164	COG1396	sequence-specific DNA binding
EBS_2165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBS_2166	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EBS_2167	COG2321	neutral zinc metallopeptidase
EBS_2169	COG0433	COG0433 Predicted ATPase
EBS_2170	COG1331	Highly conserved protein containing a thioredoxin domain
EBS_2171	COG1999	signal sequence binding
EBS_2172	COG2920	part of a sulfur-relay system
EBS_2174	COG1022	Amp-dependent synthetase and ligase
EBS_2176	COG2022	thiamine diphosphate biosynthetic process
EBS_2177	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EBS_2178	COG3842	ATPase activity
EBS_2179	COG0390	transport system, permease component
EBS_2181	COG2969	positive regulation of protein catabolic process
EBS_2182	COG0625	glutathione transferase activity
EBS_2183	COG2857	Cytochrome c1
EBS_2184	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EBS_2185	COG0723	plastoquinol--plastocyanin reductase activity
EBS_2186	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EBS_2188	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EBS_2191	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EBS_2195	COG1773	rubredoxin
EBS_2198	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EBS_2201	COG2204	response regulator
EBS_2207	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EBS_2211	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EBS_2212	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EBS_2213	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EBS_2216	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EBS_2217	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EBS_2218	COG1127	ABC transporter
EBS_2222	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EBS_2222	COG0517	IMP dehydrogenase activity
EBS_2223	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EBS_2226	COG1137	ATPase activity
EBS_2227	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EBS_2228	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBS_2231	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EBS_2234	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EBS_2235	COG0297	glycogen (starch) synthase activity
EBS_2236	COG0058	SHG alpha-glucan phosphorylase activity
EBS_2241	COG1660	Displays ATPase and GTPase activities
EBS_2243	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBS_2244	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBS_2245	COG2239	Acts as a magnesium transporter
EBS_2247	COG3043	anaerobic respiration
EBS_2248	COG0348	domain, Protein
EBS_2249	COG0437	4 iron, 4 sulfur cluster binding
EBS_2253	COG0495	leucyl-tRNA aminoacylation
EBS_2260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EBS_2261	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EBS_2270	COG1518	maintenance of DNA repeat elements
EBS_2273	COG3220	belongs to the UPF0276 family
EBS_2276	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EBS_2278	COG1530	ribonuclease E activity
EBS_2280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBS_2281	COG0312	modulator of DNA gyrase
EBS_2282	COG0312	modulator of DNA gyrase
EBS_2285	COG1011	Hydrolase
EBS_2286	COG1218	3'(2'),5'-bisphosphate nucleotidase
EBS_2288	COG5001	Diguanylate cyclase
EBS_2288	COG3300	MHYT domain
EBS_2294	COG3267	Type II secretory pathway component ExeA
EBS_2294	COG3409	Peptidoglycan-binding domain 1 protein
EBS_2296	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBS_2302	COG4968	Prepilin-type N-terminal cleavage methylation domain
EBS_2304	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EBS_2312	COG0840	transmembrane signaling receptor activity
EBS_2315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EBS_2315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EBS_2317	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EBS_2318	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EBS_2319	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EBS_2320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EBS_2322	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EBS_2323	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EBS_2328	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EBS_2329	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EBS_2331	COG0315	cyclic pyranopterin monophosphate synthase activity
EBS_2332	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EBS_2333	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBS_2334	COG0006	proline dipeptidase activity
EBS_2335	COG3079	Belongs to the UPF0149 family
EBS_2338	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EBS_2339	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EBS_2340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EBS_2341	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EBS_2343	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EBS_2345	COG0247	lactate metabolic process
EBS_2346	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EBS_2347	COG0457	Tetratricopeptide repeat
EBS_2348	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EBS_2351	COG0070	glutamate synthase
EBS_2351	COG0067	glutamate synthase
EBS_2351	COG0069	glutamate synthase activity
EBS_2353	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EBS_2354	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EBS_2362	COG0039	L-malate dehydrogenase activity
EBS_2363	COG0281	malic enzyme
EBS_2364	COG0254	rRNA binding
EBS_2368	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EBS_2369	COG0210	DNA helicase
EBS_2372	COG5001	Diguanylate cyclase
EBS_2372	COG5002	protein histidine kinase activity
EBS_2372	COG3447	MASE1 domain protein
EBS_2373	COG2204	response regulator
EBS_2374	COG0745	RESPONSE REGULATOR receiver
EBS_2374	COG3706	GGDEF domain
EBS_2378	COG3850	Histidine kinase
EBS_2378	COG4999	Histidine kinase
EBS_2378	COG3437	response regulator, receiver
EBS_2378	COG2205	protein histidine kinase activity
EBS_2379	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBS_2380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EBS_2381	COG1047	Peptidyl-prolyl cis-trans
EBS_2382	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EBS_2383	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EBS_2385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EBS_2386	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EBS_2387	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EBS_2389	COG0356	it plays a direct role in the translocation of protons across the membrane
EBS_2391	COG1475	DNA binding
EBS_2392	COG1192	Involved in chromosome partitioning
EBS_2393	COG0357	Ribosomal RNA small subunit methyltransferase G
EBS_2394	COG0625	glutathione transferase activity
EBS_2395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EBS_2396	COG3022	response to hydroperoxide
EBS_2397	COG0445	tRNA wobble uridine modification
EBS_2399	COG0714	Associated with various cellular activities
EBS_2402	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EBS_2403	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EBS_2404	COG0706	membrane insertase activity
EBS_2405	COG0594	ribonuclease P activity
EBS_2406	COG0230	Belongs to the bacterial ribosomal protein bL34 family