locus-tag	class	description
D5085_00030	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
D5085_00035	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
D5085_00060	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
D5085_00100	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
D5085_00105	ENOG4107SQU	synthase
D5085_00115	ENOG4107QKG	PfaD family
D5085_00145	ENOG4105BZ1	(ABC) transporter
D5085_00150	ENOG4105CHR	reductase
D5085_00155	ENOG4105C7H	Helicase, RecD TraA family
D5085_00160	ENOG4105C1J	atp-dependent rna helicase
D5085_00170	ENOG41082BV	acetyltransferase
D5085_00180	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_00185	ENOG4105KWG	Pfam:DUF1696
D5085_00195	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
D5085_00200	ENOG4105E0C	molybdate abc transporter
D5085_00205	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
D5085_00305	ENOG4106D4I	domain protein
D5085_00310	ENOG4107VRP	DNA repair exonuclease
D5085_00315	ENOG4105E0Y	RtcB Protein
D5085_00320	ENOG4108WIW	Aspartyl protease
D5085_00400	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
D5085_00405	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
D5085_00410	ENOG4108WUH	Transcriptional regulator, TetR family
D5085_00415	ENOG4105BZU	Histidine kinase
D5085_00420	ENOG4105FR1	rard protein
D5085_00435	ENOG4105BZU	Histidine kinase
D5085_00440	ENOG4107QYX	exodeoxyribonuclease v alpha
D5085_00445	ENOG4105DSY	exodeoxyribonuclease V, gamma
D5085_00455	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
D5085_00460	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
D5085_00465	ENOG4105WH1	Two component transcriptional regulator luxr family
D5085_00470	ENOG4105BZU	Histidine kinase
D5085_00480	ENOG4105DQQ	Major facilitator superfamily MFS_1
D5085_00485	ENOG4105CRU	nitrate reductase, alpha subunit
D5085_00490	ENOG4108IUE	nitrate reductase beta subunit
D5085_00495	ENOG4105R3A	Nitrate reductase
D5085_00500	ENOG41076YT	nitrate reductase, gamma subunit
D5085_00505	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
D5085_00510	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D5085_00515	ENOG4108V9Q	carbonic anhydrase
D5085_00520	ENOG4105C0D	helicase
D5085_00580	ENOG4105EKQ	RNA-directed DNA polymerase
D5085_00590	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
D5085_00595	ENOG4105DSY	exodeoxyribonuclease V, gamma
D5085_00600	ENOG4107QKA	exodeoxyribonuclease V beta
D5085_00605	ENOG4107QYX	exodeoxyribonuclease v alpha
D5085_00720	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_00730	ENOG4108KQ5	Integrase catalytic subunit
D5085_00810	ENOG4105DFS	Conserved Protein
D5085_00815	ENOG4105DZR	Type I site-specific deoxyribonuclease
D5085_00845	ENOG4105C4R	Atp-dependent dna helicase
D5085_00895	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
D5085_00905	ENOG4105MZU	cell filamentation protein
D5085_00915	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D5085_00915	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D5085_00925	ENOG4108JUA	Transcriptional regulator
D5085_01015	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
D5085_01075	ENOG4105DVT	helicase
D5085_01080	ENOG4108UUM	single-stranded DNA-binding protein
D5085_01120	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
D5085_01125	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D5085_01170	ENOG4108RR8	protoporphyrinogen oxidase
D5085_01235	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
D5085_01300	ENOG4107S7U	Sulfide dehydrogenase
D5085_01305	ENOG4105MW3	Cytochrome
D5085_01330	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D5085_01350	ENOG41085AN	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
D5085_01355	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_01360	ENOG4105FQT	
D5085_01375	ENOG4108VKQ	nitriC oxide reductase
D5085_01380	ENOG4105DSQ	Nitric oxide reductase
D5085_01390	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
D5085_01400	ENOG4105IJJ	transcriptional regulator, crp fnr family
D5085_01405	ENOG4105FAE	von Willebrand factor, type A
D5085_01470	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
D5085_01475	ENOG41066HZ	AIG2-like family
D5085_01510	ENOG4105K8R	UPF0145 protein
D5085_01560	ENOG410904A	RNA polymerase
D5085_01605	ENOG4107RDJ	Sulfotransferase
D5085_01610	ENOG4105VDB	UPF0125 protein
D5085_01615	ENOG4108Z1B	Cyclase dehydrase
D5085_01675	ENOG4105CRK	lysyL-tRNA synthetase
D5085_01690	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
D5085_01695	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
D5085_01700	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
D5085_01705	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
D5085_01720	ENOG4105DTJ	flagellar hook-associated protein
D5085_01725	ENOG4105E1Q	flagellar hook-associated protein
D5085_01730	ENOG4105CP9	extracellular ligand-binding receptor
D5085_01745	ENOG410870F	Cyclic nucleotide-binding protein
D5085_01750	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
D5085_01755	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
D5085_01765	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
D5085_01770	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5085_01775	ENOG4105CFG	Acts as a chaperone (By similarity)
D5085_01780	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
D5085_01785	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
D5085_01790	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_01845	ENOG4105C6K	Malic enzyme
D5085_01850	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
D5085_01870	ENOG4108VIA	integral membrane protein
D5085_01875	ENOG4105II7	pyrroline-5-carboxylate reductase
D5085_01885	ENOG41080RH	Thioredoxin
D5085_01890	ENOG4105VEJ	Heat shock protein
D5085_01895	ENOG4105K8N	protein family UPF0079, ATPase
D5085_01900	ENOG4105BZU	Histidine kinase
D5085_01905	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
D5085_01915	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
D5085_01925	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
D5085_01930	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
D5085_01935	ENOG4105VIE	preprotein translocase, subunit YajC
D5085_01945	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
D5085_01955	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
D5085_01975	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
D5085_01985	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
D5085_01990	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
D5085_01995	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
D5085_02000	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
D5085_02025	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
D5085_02035	ENOG4107QYG	anthranilate phosphoribosyltransferase
D5085_02045	ENOG4107S6X	Glycosyl transferase, family 2
D5085_02050	ENOG4105K64	Glycosyl transferase, family 2
D5085_02080	ENOG4105CMR	udp-glucose 4-epimerase
D5085_02145	ENOG4107V1M	polysaccharide export protein
D5085_02150	ENOG4105ECX	polysaccharide export
D5085_02160	ENOG41090SZ	ABC-2 type transporter
D5085_02170	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
D5085_02250	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
D5085_02315	ENOG4105YES	addiction module antidote protein
D5085_02320	ENOG4105VUH	addiction module killer protein
D5085_02355	ENOG4105WJ3	XRE family Transcriptional regulator
D5085_02385	ENOG4105WJ3	XRE family Transcriptional regulator
D5085_02395	ENOG4108TDH	Cell wall binding repeat 2-containing protein
D5085_02425	ENOG4105ECJ	Glycosyl Transferase
D5085_02430	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
D5085_02465	ENOG4105C30	Nad-dependent epimerase dehydratase
D5085_02505	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
D5085_02530	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
D5085_02535	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
D5085_02540	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
D5085_02555	ENOG4105C0H	protease
D5085_02565	ENOG4108IYU	L-aspartate oxidase
D5085_02575	ENOG4107EJC	Preprotein translocase subunit SecG
D5085_02580	ENOG4105CP7	Triose-phosphate isomerase
D5085_02585	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
D5085_02595	ENOG4105N21	Membrane
D5085_02600	ENOG4105CUT	histidyl-tRNA synthetase
D5085_02610	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
D5085_02620	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
D5085_02630	ENOG4105KHC	sulfurtransferase
D5085_02635	ENOG4105CB5	ATP-dependent DNA helicase recG
D5085_02660	ENOG4105GVR	general secretion pathway protein D
D5085_02680	ENOG4105C0B	DNA polymerase III (alpha subunit)
D5085_02685	ENOG4105C2X	Arabinose 5-phosphate isomerase
D5085_02775	ENOG4108P8R	
D5085_02805	ENOG4105N1F	Hnh endonuclease
D5085_02810	ENOG4105CTQ	phosphohexokinase
D5085_02815	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
D5085_02820	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5085_02825	ENOG4105BZU	Histidine kinase
D5085_02830	ENOG4105BZU	Histidine kinase
D5085_02835	ENOG4105DAN	ATP-dependent protease
D5085_02840	ENOG4105C5H	ABC transporter
D5085_02845	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_02855	ENOG41083J0	(ABC) transporter
D5085_02865	ENOG4105FE9	pseudouridine synthase
D5085_02870	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
D5085_02875	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
D5085_02880	ENOG4105C31	Tryptophanyl-tRNA synthetase
D5085_02885	ENOG4108Z4T	Peptidase M50
D5085_02890	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
D5085_02895	ENOG4105DB7	PHP domain protein
D5085_02910	ENOG4108ZNX	Heat shock protein
D5085_02915	ENOG4105W39	Membrane
D5085_02920	ENOG4105BZU	Histidine kinase
D5085_02940	ENOG4108NVR	Methyl-accepting chemotaxis
D5085_02945	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_02955	ENOG4107YTP	response regulator receiver protein
D5085_02985	ENOG4105DEU	major facilitator superfamily
D5085_03015	ENOG4105CDY	transcriptional regulatory protein
D5085_03055	ENOG4108VPT	UPF0234 protein
D5085_03060	ENOG4105T95	Thiol disulfide interChange protein
D5085_03065	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
D5085_03070	ENOG4105BZU	Histidine kinase
D5085_03080	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
D5085_03090	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
D5085_03100	ENOG4105M08	Membrane
D5085_03120	ENOG41081XE	plasmid maintenance system antidote protein, xre family
D5085_03125	ENOG41080ET	plasmid maintenance system killer protein
D5085_03135	ENOG4105M3Z	response regulator
D5085_03145	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_03150	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
D5085_03155	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
D5085_03160	ENOG4105BZU	Histidine kinase
D5085_03165	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_03170	ENOG4108V3W	Chemotaxis protein, CheW
D5085_03175	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_03180	ENOG4108VYJ	response regulator receiver protein
D5085_03185	ENOG4107QJE	Chromosome Partitioning Protein
D5085_03200	ENOG4107QHF	type ii secretion system protein e
D5085_03220	ENOG4108JA2	transcriptioN-repair coupling factor
D5085_03230	ENOG4108ETH	Formylglycinamide ribotide synthetase
D5085_03235	ENOG4105F8V	Hydrolase, tatD family
D5085_03245	ENOG4107R88	Chemotaxis protein (CheV)
D5085_03255	ENOG4105BZU	Histidine kinase
D5085_03260	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_03280	ENOG4107QMS	site-determining protein
D5085_03330	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
D5085_03335	ENOG4105BZU	Histidine kinase
D5085_03340	ENOG4108UNF	response regulator
D5085_03345	ENOG4105C94	Transporter
D5085_03370	ENOG4108N3W	hemolysin secretion protein
D5085_03400	ENOG4105BZU	Histidine kinase
D5085_03415	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
D5085_03420	ENOG4107QZM	n-acetylglutamate synthase
D5085_03425	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5085_03430	ENOG4108JEM	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5085_03435	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
D5085_03440	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
D5085_03445	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
D5085_03450	ENOG4105BZU	Histidine kinase
D5085_03460	ENOG4105CIH	Imidazole acetol-phosphate transaminase
D5085_03465	ENOG4105DHT	Metal Dependent Phosphohydrolase
D5085_03495	ENOG4105CQ7	ATP-dependent helicase
D5085_03505	ENOG4105BZU	Histidine kinase
D5085_03510	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
D5085_03515	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
D5085_03520	ENOG4105K46	50S ribosomal protein l27
D5085_03525	ENOG4105CA9	Pyruvate kinase
D5085_03535	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
D5085_03550	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
D5085_03560	ENOG4107S21	permease
D5085_03575	ENOG4108AEY	RNA polymerase sigma factor
D5085_03595	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
D5085_03600	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
D5085_03605	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
D5085_03615	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D5085_03635	ENOG4108RAC	Rubrerythrin
D5085_03640	ENOG4108N3W	hemolysin secretion protein
D5085_03645	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5085_03650	ENOG4108IAB	Phoh family
D5085_03655	ENOG4105CFP	Peptidase U32
D5085_03665	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
D5085_03670	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
D5085_03680	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D5085_03695	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
D5085_03700	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
D5085_03705	ENOG4105CSR	polyphosphate kinase 2
D5085_03715	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
D5085_03720	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
D5085_03725	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
D5085_03730	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
D5085_03740	ENOG4105Q2H	domain protein
D5085_03745	ENOG4105C8V	SAICAR synthetase
D5085_03750	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
D5085_03755	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
D5085_03760	ENOG4105E33	succinate dehydrogenase
D5085_03765	ENOG4105D9M	gamma-glutamylcysteine synthetase
D5085_03805	ENOG4105CAQ	asparagine synthetase
D5085_03815	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D5085_03825	ENOG4108UW5	maltose o-acetyltransferase
D5085_03830	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D5085_03860	ENOG4105CB5	ATP-dependent DNA helicase recG
D5085_03875	ENOG4107QJZ	Glycosyl transferase, family 2
D5085_03895	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
D5085_03900	ENOG4105BZU	Histidine kinase
D5085_03905	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_03925	ENOG4105C0P	Mg chelatase subunit ChlI
D5085_03930	ENOG4105W0Z	cytoplasmic protein
D5085_03935	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
D5085_03950	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
D5085_03955	ENOG4105D1S	lipid A biosynthesis
D5085_04025	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_04050	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_04055	ENOG4108HMN	Caspase domain
D5085_04065	ENOG4108HMN	Caspase domain
D5085_04110	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_04160	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_04185	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
D5085_04235	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
D5085_04260	ENOG4105C3J	Cysteine desulfurase
D5085_04295	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
D5085_04305	ENOG4105F0I	Aminotransferase
D5085_04310	ENOG4105DZ1	carboxypeptidase
D5085_04315	ENOG4105K6T	rare lipoprotein A
D5085_04320	ENOG4105CVE	Lytic murein transglycosylase
D5085_04325	ENOG4105CNI	cell division protein FtsW
D5085_04330	ENOG4105CJN	penicillin-binding protein
D5085_04335	ENOG4105VQ7	Rod shape-determining protein MreD
D5085_04340	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
D5085_04345	ENOG4105DFF	Rod shape-determining protein mreb
D5085_04355	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
D5085_04370	ENOG4108UJD	30S ribosomal protein S9
D5085_04380	ENOG4105HF0	Membrane
D5085_04395	ENOG4105EYM	Major Facilitator superfamily
D5085_04400	ENOG4105CA0	peroxidase
D5085_04405	ENOG4105C3M	thioredoxin reductase
D5085_04410	ENOG4108KMM	Diguanylate cyclase
D5085_04415	ENOG4105BZU	Histidine kinase
D5085_04425	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
D5085_04430	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
D5085_04435	ENOG4105BZ8	glutamate synthase
D5085_04440	ENOG4105DDK	oxidoreductase, beta subunit
D5085_04445	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
D5085_04470	ENOG4107T0K	Adenylate cyclase
D5085_04480	ENOG4105C2D	reductase
D5085_04485	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
D5085_04490	ENOG4108IYH	Dna topoisomerase
D5085_04530	ENOG4107QMH	DNA methylase
D5085_04590	ENOG4105NI8	Cytosine-specific methyltransferase
D5085_04625	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_04760	ENOG4108IJ9	(ABC) transporter
D5085_04805	ENOG4105MYN	Zinc uptake regulation protein
D5085_04815	ENOG4105FDK	ABC transporter
D5085_04835	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
D5085_04845	ENOG4105BZU	Histidine kinase
D5085_04850	ENOG4105BZU	Histidine kinase
D5085_04865	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
D5085_04870	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
D5085_04885	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
D5085_04895	ENOG4107RIQ	Sulfate adenylate transferase
D5085_04900	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D5085_04915	ENOG4105BZU	Histidine kinase
D5085_04920	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
D5085_04925	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
D5085_04930	ENOG4107QJE	Chromosome Partitioning Protein
D5085_04935	ENOG4105FA0	parb-like partition protein
D5085_04945	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
D5085_04950	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
D5085_04955	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
D5085_04960	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
D5085_04965	ENOG4105BZU	Histidine kinase
D5085_04980	ENOG4105BZU	Histidine kinase
D5085_05045	ENOG4105M5K	heptosyltransferase
D5085_05050	ENOG4105DKP	glycosyl transferase, family 9
D5085_05055	ENOG4105CPK	Glycosyl transferase (Group 1
D5085_05060	ENOG4105C34	Pseudouridine synthase
D5085_05065	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5085_05070	ENOG4105CZX	twitching motility protein
D5085_05075	ENOG4105CZX	twitching motility protein
D5085_05080	ENOG4105C0H	protease
D5085_05085	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
D5085_05090	ENOG4108JQB	penicillin-binding protein 1C
D5085_05100	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_05105	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
D5085_05115	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
D5085_05120	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
D5085_05125	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
D5085_05130	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
D5085_05145	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
D5085_05150	ENOG4108UJU	UPF0301 protein
D5085_05155	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
D5085_05165	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
D5085_05170	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
D5085_05175	ENOG41082J7	Rhodanese domain protein
D5085_05185	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
D5085_05190	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
D5085_05195	ENOG4108ZT0	50S ribosomal protein l17
D5085_05200	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D5085_05205	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
D5085_05210	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
D5085_05215	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5085_05220	ENOG41067V7	50S ribosomal protein L36
D5085_05225	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
D5085_05230	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
D5085_05235	ENOG4105VPB	50S ribosomal protein L30
D5085_05240	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
D5085_05245	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
D5085_05250	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
D5085_05255	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
D5085_05260	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
D5085_05265	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5085_05270	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
D5085_05275	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
D5085_05285	ENOG41083MP	50s ribosomal protein l29
D5085_05290	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
D5085_05295	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
D5085_05300	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
D5085_05305	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
D5085_05310	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5085_05315	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
D5085_05320	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
D5085_05325	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
D5085_05330	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
D5085_05335	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
D5085_05340	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
D5085_05345	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
D5085_05350	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
D5085_05360	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D5085_05365	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
D5085_05370	ENOG4108VZM	50s ribosomal protein L10
D5085_05375	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
D5085_05380	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
D5085_05385	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
D5085_05390	ENOG4105PM1	preprotein translocase subunit SecE
D5085_05400	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
D5085_05420	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
D5085_05425	ENOG4105EAM	Na Pi-cotransporter
D5085_05470	ENOG4105BZU	Histidine kinase
D5085_05475	ENOG4108VYJ	response regulator receiver protein
D5085_05480	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_05490	ENOG4108JQC	penicillin-binding protein 1A
D5085_05500	ENOG4108NEV	two component transcriptional regulator, LytTR family
D5085_05570	ENOG4105E18	UPF0276 protein
D5085_05600	ENOG4107QTF	adenylosuccinate lyase
D5085_05605	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
D5085_05610	ENOG4108ZP8	Acetolactate synthase small subunit
D5085_05615	ENOG4105C7K	acetolactate synthase
D5085_05620	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
D5085_05625	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
D5085_05630	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_05685	ENOG4105CHH	sulfate transporter
D5085_05690	ENOG4105D64	Mechanosensitive ion channel
D5085_05705	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
D5085_05710	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D5085_05715	ENOG4105F0V	Cell wall hydrolase
D5085_05720	ENOG4108ZZ3	UPF0260 protein
D5085_05725	ENOG41072GX	Peptidase M22 Glycoprotease
D5085_05740	ENOG4105DUM	transcriptional regulator, lysR family
D5085_05745	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
D5085_05755	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
D5085_05760	ENOG4105D60	lipoprotein releasing system transmembrane protein
D5085_05765	ENOG4108JQ5	ABC transporter
D5085_05790	ENOG4107QRG	dna polymerase iii
D5085_05795	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
D5085_05870	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
D5085_05875	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
D5085_05890	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
D5085_05900	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
D5085_05915	ENOG4108ZAI	phosphatidylglycerophosphatase a
D5085_05920	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
D5085_05925	ENOG4107YIM	Involved in the transcription termination process (By similarity)
D5085_05930	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
D5085_05935	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
D5085_05945	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
D5085_05950	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
D5085_05955	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
D5085_06025	ENOG4105BZU	Histidine kinase
D5085_06030	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
D5085_06040	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
D5085_06065	ENOG4108Z0R	Transferase
D5085_06070	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
D5085_06090	ENOG4105K63	Thioredoxin
D5085_06175	ENOG4107QHF	type ii secretion system protein e
D5085_06195	ENOG4105DFG	type I secretion outer membrane protein
D5085_06200	ENOG4108KE4	O-methyltransferase
D5085_06205	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
D5085_06220	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
D5085_06235	ENOG4105MQ3	flagellar protein FliS
D5085_06240	ENOG4105DTS	flagellar hook-associated
D5085_06250	ENOG4105I03	Flagellin
D5085_06255	ENOG4105I03	Flagellin
D5085_06260	ENOG4105I03	Flagellin
D5085_06270	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
D5085_06275	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
D5085_06305	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
D5085_06310	ENOG4107QJZ	Glycosyl transferase, family 2
D5085_06315	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
D5085_06340	ENOG4105EPH	radical SAM domain protein
D5085_06345	ENOG4107QPD	alcohol dehydrogenase
D5085_06365	ENOG4108IUS	Transketolase
D5085_06370	ENOG4108HHA	Transketolase
D5085_06425	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
D5085_06435	ENOG4105C26	Dehydrogenase
D5085_06445	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
D5085_06450	ENOG4105EQQ	protein containing aminopeptidase domain
D5085_06455	ENOG4105F0R	Cytidylyltransferase
D5085_06460	ENOG4105C5E	polysaccharide biosynthesis protein
D5085_06505	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
D5085_06515	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
D5085_06520	ENOG4105EI2	Pseudouridine synthase
D5085_06525	ENOG4108S0S	Nucleotidyl transferase
D5085_06535	ENOG4105CX6	glutaminyL-tRNA synthetase
D5085_06540	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
D5085_06545	ENOG4105W49	UPF0434 protein
D5085_06550	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
D5085_06555	ENOG4105D38	putrescine abc transporter
D5085_06560	ENOG4105F38	ABC transporter, permease
D5085_06565	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
D5085_06575	ENOG4105NWN	ApaG protein
D5085_06580	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
D5085_06585	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D5085_06590	ENOG4105C03	ribonuclease
D5085_06595	ENOG4105BZU	Histidine kinase
D5085_06605	ENOG4105D06	uba thif-type nad fad binding protein
D5085_06615	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
D5085_06620	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
D5085_06625	ENOG4105DFA	alanine racemase domain protein
D5085_06645	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
D5085_06650	ENOG4105DR5	peptidase
D5085_06655	ENOG4105CHR	reductase
D5085_06660	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
D5085_06665	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
D5085_06670	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
D5085_06675	ENOG4105VGS	50s ribosomal protein l32
D5085_06680	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
D5085_06685	ENOG4108UHJ	MAF-like protein
D5085_06705	ENOG4108RRZ	Transcription elongation factor GreB
D5085_06720	ENOG4105MJ2	Competence protein
D5085_06725	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
D5085_06755	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
D5085_06760	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
D5085_06765	ENOG4105VFE	sira family
D5085_06785	ENOG4105DWF	phosphomethylpyrimidine kinase
D5085_06820	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
D5085_06855	ENOG4105CUW	cytochrome C-TYPE protein
D5085_06925	ENOG4105CUW	cytochrome C-TYPE protein
D5085_07070	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
D5085_07075	ENOG4105C4R	Atp-dependent dna helicase
D5085_07090	ENOG4105CUZ	uba thif-type nad fad binding protein
D5085_07095	ENOG4105D52	delta-aminolevulinic acid dehydratase
D5085_07100	ENOG4105E2X	shikimate dehydrogenase
D5085_07130	ENOG4105K5B	UPF0225 protein
D5085_07205	ENOG4105EZR	dyp-type peroxidase family protein
D5085_07215	ENOG4108JA1	polyketide synthase
D5085_07220	ENOG4105K5M	30s ribosomal protein S16
D5085_07225	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
D5085_07230	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
D5085_07235	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
D5085_07245	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
D5085_07250	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
D5085_07275	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
D5085_07290	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
D5085_07295	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
D5085_07305	ENOG4105KTH	gatB Yqey
D5085_07310	ENOG4105VCC	30S ribosomal protein S21
D5085_07320	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
D5085_07325	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
D5085_07330	ENOG4107YU2	histidine triad (hIT) protein
D5085_07335	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
D5085_07340	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
D5085_07345	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
D5085_07350	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
D5085_07355	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
D5085_07360	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
D5085_07365	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
D5085_07370	ENOG4108UKZ	OsmC family
D5085_07430	ENOG410756H	nucleotidyltransferase
D5085_07440	ENOG410756H	nucleotidyltransferase
D5085_07460	ENOG4105C0D	helicase
D5085_07515	ENOG4105C4R	Atp-dependent dna helicase
D5085_07590	ENOG4107QTH	restriction modification system DNA specificity domain
D5085_07660	ENOG410756H	nucleotidyltransferase
D5085_07670	ENOG4105FB9	CRISPR-associated protein
D5085_07755	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
D5085_07760	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
D5085_07840	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
D5085_07850	ENOG4105C2C	drug resistance transporter, Bcr CflA
D5085_07855	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
D5085_07870	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
D5085_07875	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
D5085_07880	ENOG4105DR5	peptidase
D5085_07890	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
D5085_07895	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
D5085_07900	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
D5085_07905	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
D5085_07910	ENOG4105CPF	Cell wall formation (By similarity)
D5085_07915	ENOG4105D4A	Cell wall formation (By similarity)
D5085_07920	ENOG4105DFU	Cell wall formation (By similarity)
D5085_07925	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
D5085_07930	ENOG4105CNI	cell division protein FtsW
D5085_07935	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
D5085_07940	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
D5085_07945	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
D5085_07950	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
D5085_07955	ENOG4105CJN	penicillin-binding protein
D5085_07960	ENOG4106932	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
D5085_07965	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
D5085_07970	ENOG4108V6E	Cell division protein mraZ
D5085_07990	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
D5085_07995	ENOG4108EX3	reductase
D5085_08000	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
D5085_08005	ENOG4105C1A	potassium transporter peripheral membrane
D5085_08010	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D5085_08015	ENOG4108KDI	dmso reductase anchor subunit
D5085_08020	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
D5085_08025	ENOG4105DB1	molybdopterin oxidoreductase
D5085_08035	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
D5085_08040	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
D5085_08045	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D5085_08050	ENOG4105C75	arginyL-tRNA synthetase
D5085_08065	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
D5085_08075	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
D5085_08080	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
D5085_08085	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
D5085_08090	ENOG4105C02	permease
D5085_08110	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
D5085_08115	ENOG4105D49	3-dehydroquinate synthase
D5085_08130	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
D5085_08135	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
D5085_08165	ENOG4105KG1	l-proline 3-hydroxylase
D5085_08175	ENOG4105DC1	bifunctional purine biosynthesis protein purh
D5085_08195	ENOG4105CQS	hydrogenase expression formation protein HypD
D5085_08205	ENOG41089BK	Glutamine amido-transferase
D5085_08215	ENOG4105CS1	NAD(P)H quinone oxidoreductase
D5085_08225	ENOG4105SYT	Methylenetetrahydrofolate reductase
D5085_08230	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
D5085_08235	ENOG4105D2N	Aldolase
D5085_08240	ENOG4105DDQ	anthranilate synthase
D5085_08245	ENOG4108I0Q	anthranilate phosphoribosyltransferase
D5085_08250	ENOG4105DK0	Indole-3-glycerol phosphate synthase
D5085_08255	ENOG4105ECY	inositol monophosphatase
D5085_08260	ENOG4108NVR	Methyl-accepting chemotaxis
D5085_08270	ENOG4105F0N	pyrophosphate phospho-hydrolase
D5085_08275	ENOG4105BZU	Histidine kinase
D5085_08280	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
D5085_08285	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
D5085_08290	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
D5085_08295	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
D5085_08300	ENOG4105KDC	50s ribosomal protein l28
D5085_08305	ENOG4105W0E	50S ribosomal protein L33
D5085_08325	ENOG4105BZU	Histidine kinase
D5085_08355	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
D5085_08365	ENOG4107E2E	PKHD-type hydroxylase
D5085_08370	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
D5085_08395	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
D5085_08400	ENOG4105C2C	drug resistance transporter, Bcr CflA
D5085_08425	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
D5085_08430	ENOG4108UUM	single-stranded DNA-binding protein
D5085_08435	ENOG4105DJV	ribulose-phosphate 3-epimerase
D5085_08440	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
D5085_08445	ENOG4105CRQ	synthase (Component I)
D5085_08450	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
D5085_08460	ENOG4108JU6	CBS domain protein
D5085_08470	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
D5085_08475	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
D5085_08480	ENOG4107YD3	Thioesterase
D5085_08485	ENOG4105E02	MotA TolQ exbB proton channel
D5085_08490	ENOG4105M8F	Biopolymer transport protein exbD tolR
D5085_08500	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
D5085_08505	ENOG4105KCK	Peptidoglycan-associated lipoprotein
D5085_08515	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
D5085_08525	ENOG4105C5H	ABC transporter
D5085_08550	ENOG4105E4G	Type IV pilus
D5085_08555	ENOG4105TNG	K13735 adhesin invasin
D5085_08585	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
D5085_08590	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
D5085_08595	ENOG4105DIJ	Phosphoethanolamine transferase
D5085_08610	ENOG4107S7U	Sulfide dehydrogenase
D5085_08630	ENOG4105D0M	Protease HtpX homolog
D5085_08635	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
D5085_08645	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
D5085_08650	ENOG4105DD5	Flagellar motor switch protein
D5085_08655	ENOG4105VTB	flagellar biosynthesis protein fliO
D5085_08660	ENOG4105CN7	Flagellar biosynthetic protein FliP
D5085_08665	ENOG4105VS8	Flagellar biosynthetic protein fliq
D5085_08670	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
D5085_08675	ENOG4105D00	flagellar biosynthetic protein flhB
D5085_08680	ENOG4105D7B	Flagellar biosynthesis protein flha
D5085_08685	ENOG4105FZW	flagellar biosynthesis regulator FlhF
D5085_08690	ENOG4107R21	site-determining protein
D5085_08695	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D5085_08700	ENOG4108VYJ	response regulator receiver protein
D5085_08710	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_08715	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
D5085_08720	ENOG4105E14	MotA TolQ exbB proton channel
D5085_08725	ENOG4106VK6	Flagellar motor protein
D5085_08730	ENOG4107QJE	Chromosome Partitioning Protein
D5085_08740	ENOG4108V3W	Chemotaxis protein, CheW
D5085_08755	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
D5085_08765	ENOG4105D4P	Coproporphyrinogen iii oxidase
D5085_08770	ENOG4108HRK	Histidine kinase
D5085_08775	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
D5085_08780	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
D5085_08785	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
D5085_08795	ENOG4108JIR	Flagellum-specific ATP synthase
D5085_08805	ENOG4105WF4	Flagellar hook-length control protein
D5085_08810	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
D5085_08815	ENOG41063SB	peptidase
D5085_08820	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
D5085_08825	ENOG41080HT	Transcriptional regulator, arsr family
D5085_08830	ENOG4107YZP	Rhodanese domain protein
D5085_08835	ENOG4105VW4	glutaredoxin 3
D5085_08855	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
D5085_08885	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
D5085_08895	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
D5085_08900	ENOG4105BZ8	glutamate synthase
D5085_08905	ENOG4105CBC	glutamate synthase
D5085_08910	ENOG4105CHH	sulfate transporter
D5085_08925	ENOG4105FAE	von Willebrand factor, type A
D5085_08940	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
D5085_08950	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D5085_08955	ENOG4105BZU	Histidine kinase
D5085_08970	ENOG4105DUM	transcriptional regulator, lysR family
D5085_08990	ENOG4105KNY	Microcompartments protein
D5085_08995	ENOG4108WT6	Carbon dioxide concentrating mechanism protein
D5085_09020	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
D5085_09025	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
D5085_09030	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_09045	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
D5085_09105	ENOG4105ESV	Glycosyl transferase, family 4
D5085_09110	ENOG4105EGS	Mechanosensitive ion channel
D5085_09130	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
D5085_09135	ENOG4105D3R	alkyl hydroperoxide reductase
D5085_09140	ENOG4105CSR	polyphosphate kinase 2
D5085_09145	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_09160	ENOG4108JJA	ABC, transporter
D5085_09165	ENOG4105CSA	Coproporphyrinogen iii oxidase
D5085_09175	ENOG4105C25	Primosomal protein n'
D5085_09180	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
D5085_09190	ENOG4105C8N	cysteinyl-tRNA synthetase
D5085_09195	ENOG4105BZU	Histidine kinase
D5085_09200	ENOG4107R88	Chemotaxis protein (CheV)
D5085_09225	ENOG4105DZB	Electron transport complex
D5085_09235	ENOG4105D6A	Electron transport complex
D5085_09240	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
D5085_09245	ENOG4108R3D	Electron transport complex
D5085_09250	ENOG4105DGN	Electron transport complex
D5085_09255	ENOG4108KPB	Flagellar basal-body rod protein FlgF
D5085_09265	ENOG410822I	Flagellar hook capping protein
D5085_09270	ENOG4108ZC9	flagellar basal-body rod protein flgc
D5085_09275	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
D5085_09280	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
D5085_09285	ENOG4105ERG	peptidase m48, ste24p
D5085_09290	ENOG4105C5H	ABC transporter
D5085_09300	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_09315	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
D5085_09325	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
D5085_09330	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
D5085_09335	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
D5085_09340	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
D5085_09360	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_09365	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
D5085_09370	ENOG41080ZE	Adenylate cyclase
D5085_09380	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
D5085_09400	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
D5085_09405	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D5085_09410	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D5085_09415	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D5085_09420	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
D5085_09425	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
D5085_09430	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
D5085_09435	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
D5085_09440	ENOG4105FS0	cytoplasmic membrane protein
D5085_09445	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
D5085_09450	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
D5085_09535	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
D5085_09540	ENOG4108M8S	permease YjgP YjgQ family protein
D5085_09545	ENOG4108K5H	permease YjgP YjgQ family protein
D5085_09550	ENOG4105D8G	Major Facilitator superfamily
D5085_09585	ENOG4107R39	(ABC) transporter
D5085_09600	ENOG4105EYA	deoxyribonuclease
D5085_09615	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
D5085_09620	ENOG4105K63	Thioredoxin
D5085_09635	ENOG4105EYH	Exonuclease
D5085_09645	ENOG4106RE7	Cytochrome
D5085_09650	ENOG4105MPD	Cytochrome
D5085_09700	ENOG41071TK	Uncharacterised protein family (UPF0150)
D5085_09740	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_09870	ENOG4105DFU	Cell wall formation (By similarity)
D5085_09875	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
D5085_09885	ENOG4105C7S	Dehydrogenase
D5085_09895	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_09900	ENOG4105DS4	PAS PAC sensor Signal transduction histidine kinase
D5085_09910	ENOG4105BZU	Histidine kinase
D5085_09920	ENOG4107QP8	phosphohexose isomerase
D5085_09925	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
D5085_09930	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
D5085_09935	ENOG4105DVT	helicase
D5085_09945	ENOG4108JDX	DNA polymerase iii, epsilon subunit
D5085_09950	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
D5085_09955	ENOG4105F2W	methyltransferase
D5085_09960	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
D5085_09965	ENOG4105E9H	Lytic Murein transglycosylase
D5085_09975	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
D5085_09980	ENOG4105CPC	Aldo Keto reductase
D5085_09990	ENOG4105BZU	Histidine kinase
D5085_09995	ENOG4105D05	Receptor
D5085_10005	ENOG4105BZU	Histidine kinase
D5085_10010	ENOG4105BZU	Histidine kinase
D5085_10015	ENOG4105CJR	Integral membrane protein (MviN
D5085_10020	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
D5085_10025	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
D5085_10030	ENOG4105XA0	heptosyltransferase ii
D5085_10035	ENOG4108FN7	Aldo keto reductase
D5085_10040	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
D5085_10050	ENOG4105CM2	brancheD-chain amino acid aminotransferase
D5085_10055	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
D5085_10060	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
D5085_10065	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
D5085_10075	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
D5085_10080	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
D5085_10085	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
D5085_10090	ENOG4105C3G	gtp-binding protein
D5085_10095	ENOG4105W3S	hemerythrin-like, metal-binding protein
D5085_10115	ENOG4105E6M	Sulphatase-modifying factor protein
D5085_10135	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5085_10140	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_10145	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5085_10150	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_10165	ENOG4108IEH	NADH dehydrogenase subunit g
D5085_10170	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
D5085_10175	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_10180	ENOG4105DF2	NADH dehydrogenase subunit j
D5085_10185	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_10195	ENOG4105C8S	subunit m
D5085_10200	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_10205	ENOG41060IM	Heme exporter protein
D5085_10215	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
D5085_10220	ENOG4105DA4	cytochrome c-type biogenesis protein
D5085_10225	ENOG4107QX9	Thiol disulfide interChange protein
D5085_10230	ENOG4105KWW	Biogenesis protein
D5085_10235	ENOG4108M1T	Cytochrome c-type biogenesis protein
D5085_10240	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
D5085_10245	ENOG4105C2N	RNA methyltransferase TrmH family group 3
D5085_10250	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
D5085_10275	ENOG4105CHH	sulfate transporter
D5085_10280	ENOG4107RUE	extracellular solute-binding protein family 1
D5085_10370	ENOG4105CY0	Metallo-Beta-Lactamase
D5085_10410	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
D5085_10420	ENOG4105C30	Nad-dependent epimerase dehydratase
D5085_10545	ENOG4105CB5	ATP-dependent DNA helicase recG
D5085_10655	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
D5085_10700	ENOG4108TJN	glycosyl transferase group 1
D5085_10705	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
D5085_10735	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
D5085_10745	ENOG4105C30	Nad-dependent epimerase dehydratase
D5085_10815	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
D5085_10830	ENOG4105K64	Glycosyl transferase, family 2
D5085_10880	ENOG4105VUH	addiction module killer protein
D5085_10885	ENOG4105YES	addiction module antidote protein
D5085_10915	ENOG4108TJN	glycosyl transferase group 1
D5085_10920	ENOG4105CMR	udp-glucose 4-epimerase
D5085_10940	ENOG4107QHF	type ii secretion system protein e
D5085_10945	ENOG4105D7Q	type ii secretion system
D5085_10950	ENOG4108VAU	general secretion pathway protein G
D5085_10990	ENOG4105GVR	general secretion pathway protein D
D5085_11025	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
D5085_11075	ENOG4105FAW	cDP-glucose 4,6-dehydratase
D5085_11170	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
D5085_11175	ENOG4106WTF	Glycosyl transferase, family 2
D5085_11180	ENOG4105BZU	Histidine kinase
D5085_11185	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
D5085_11190	ENOG4105CAK	Cell division ATP-binding protein ftsE
D5085_11200	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
D5085_11205	ENOG4105CHV	Transcription elongation factor NusA
D5085_11210	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
D5085_11215	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
D5085_11220	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
D5085_11225	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
D5085_11230	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
D5085_11235	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
D5085_11265	ENOG4105DKP	glycosyl transferase, family 9
D5085_11270	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
D5085_11275	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
D5085_11285	ENOG4105CD8	aminopeptidase N
D5085_11305	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
D5085_11310	ENOG4107QQG	Dehydrogenase
D5085_11315	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
D5085_11320	ENOG4105ERG	peptidase m48, ste24p
D5085_11325	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
D5085_11340	ENOG4107QMP	dna polymerase iii subunits gamma and tau
D5085_11345	ENOG4105D1H	recombination factor protein RarA
D5085_11350	ENOG4105WMR	Protein CrcB homolog
D5085_11355	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
D5085_11360	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
D5085_11365	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
D5085_11370	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
D5085_11375	ENOG4105HHA	aminodeoxychorismate lyase
D5085_11380	ENOG4105BZU	Histidine kinase
D5085_11390	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
D5085_11395	ENOG41081YB	ApbE family
D5085_11400	ENOG4105CEN	a g-specific adenine glycosylase
D5085_11405	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
D5085_11445	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
D5085_11455	ENOG4105C3R	Methionine synthase
D5085_11465	ENOG4105C1J	atp-dependent rna helicase
D5085_11470	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
D5085_11475	ENOG4105BZU	Histidine kinase
D5085_11480	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
D5085_11485	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
D5085_11490	ENOG4107QKW	extracellular solute-binding protein family 1
D5085_11500	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
D5085_11510	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
D5085_11530	ENOG4107T0K	Adenylate cyclase
D5085_11540	ENOG4107TUY	Histidine kinase
D5085_11555	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D5085_11560	ENOG4105ECY	inositol monophosphatase
D5085_11575	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
D5085_11580	ENOG4107QI6	Cysteine desulfurase
D5085_11585	ENOG4105C3J	Cysteine desulfurase
D5085_11590	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
D5085_11595	ENOG4108Z4V	iron-sulfur cluster assembly
D5085_11600	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
D5085_11605	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
D5085_11610	ENOG4108ZIT	Ferredoxin, 2FE-2S
D5085_11615	ENOG4105WVQ	Fe-S assembly protein IscX
D5085_11620	ENOG4105KQC	Competence protein
D5085_11625	ENOG4105VFB	Binds the 23S rRNA (By similarity)
D5085_11645	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
D5085_11655	ENOG4108UNF	response regulator
D5085_11660	ENOG4105M3Z	response regulator
D5085_11665	ENOG4108ZGA	chew protein
D5085_11670	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_11675	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_11690	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
D5085_11695	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
D5085_11700	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
D5085_11705	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
D5085_11710	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
D5085_11715	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
D5085_11725	ENOG4105E96	Colicin v production protein
D5085_11730	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
D5085_11740	ENOG4105VNG	YcgL domain-containing protein
D5085_11745	ENOG4105CGH	5'-nucleotidase
D5085_11770	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
D5085_11800	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
D5085_11815	ENOG4105YYT	phage shock protein B
D5085_11830	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
D5085_11870	ENOG4105E0X	reductase
D5085_11875	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
D5085_11890	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
D5085_11905	ENOG4105C59	p-type ATPase
D5085_11910	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
D5085_11930	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_11935	ENOG4108V3W	Chemotaxis protein, CheW
D5085_11940	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
D5085_11950	ENOG4105BZU	Histidine kinase
D5085_11955	ENOG4108VYJ	response regulator receiver protein
D5085_11960	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_11960	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_11970	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
D5085_11975	ENOG4108VYJ	response regulator receiver protein
D5085_11980	ENOG4108NVR	Methyl-accepting chemotaxis
D5085_11990	ENOG4105QD0	anti-sigma regulatory factor serine threonine protein kinase
D5085_11995	ENOG4105QD0	anti-sigma regulatory factor serine threonine protein kinase
D5085_12000	ENOG4105FUA	antagonist
D5085_12005	ENOG4107MMM	Anti-sigma-factor antagonist
D5085_12015	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
D5085_12020	ENOG4105BZU	Histidine kinase
D5085_12025	ENOG410807Z	Modulation of CheA activity in response to attractants (Chemotaxis
D5085_12030	ENOG4105BZU	Histidine kinase
D5085_12040	ENOG4105BZU	Histidine kinase
D5085_12210	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
D5085_12225	ENOG4107S1V	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
D5085_12240	ENOG4107QN1	sodium solute
D5085_12250	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
D5085_12295	ENOG4108RJ7	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity)
D5085_12300	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
D5085_12310	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
D5085_12315	ENOG4105BZU	Histidine kinase
D5085_12325	ENOG4108MRH	transcriptional regulatory protein
D5085_12330	ENOG4105BZU	Histidine kinase
D5085_12335	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
D5085_12350	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
D5085_12360	ENOG4105C2M	dna polymerase I
D5085_12365	ENOG4108NVR	Methyl-accepting chemotaxis
D5085_12375	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
D5085_12380	ENOG4105D0A	hydroxylase
D5085_12385	ENOG4107RAQ	aminopeptidase
D5085_12395	ENOG4106855	Competence protein
D5085_12420	ENOG4107S2Z	UPF0761 membrane protein
D5085_12430	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
D5085_12435	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
D5085_12440	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
D5085_12445	ENOG4107RDB	Major Facilitator
D5085_12450	ENOG4105CN1	protease
D5085_12455	ENOG4105PXI	polysaccharide deacetylase
D5085_12465	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
D5085_12470	ENOG41076E6	Uroporphyrinogen-III Synthase
D5085_12545	ENOG4105BZU	Histidine kinase
D5085_12550	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_12555	ENOG4105CJW	magnesium transporter
D5085_12560	ENOG4105BZU	Histidine kinase
D5085_12565	ENOG4105CGA	flagellar basal-body rod protein FlgG
D5085_12570	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
D5085_12575	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
D5085_12580	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
D5085_12610	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
D5085_12620	ENOG4105F8C	transglutaminase domain-containing protein
D5085_12625	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
D5085_12630	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
D5085_12640	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
D5085_12645	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
D5085_12650	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
D5085_12655	ENOG4105HBR	Rna-binding protein
D5085_12660	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
D5085_12665	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D5085_12670	ENOG4105EEI	dihydropteroate synthase
D5085_12680	ENOG4105C32	Amino acid ABC transporter (Permease)
D5085_12690	ENOG4105C0Z	ABC transporter
D5085_12695	ENOG4108IV0	ABC, transporter
D5085_12705	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
D5085_12720	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
D5085_12735	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
D5085_12765	ENOG4105IBP	Cyclic peptide transporter
D5085_12795	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
D5085_12800	ENOG4105P1D	4fe-4s ferredoxin, iron-sulfur binding
D5085_12805	ENOG4105CNW	domain protein
D5085_12810	ENOG4105KXW	Ferredoxin
D5085_12815	ENOG4105U82	Ferredoxin
D5085_12820	ENOG4105PS4	nifq family
D5085_12845	ENOG4105DZR	Type I site-specific deoxyribonuclease
D5085_12855	ENOG4105EKX	Restriction modification system DNA (Specificity
D5085_12865	ENOG4105CVR	type I restriction-modification system
D5085_12905	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
D5085_12915	ENOG4105C4R	Atp-dependent dna helicase
D5085_12930	ENOG4105CSM	endonuclease III
D5085_12940	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
D5085_12945	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
D5085_12955	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
D5085_12960	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
D5085_12965	ENOG4105CDU	Replicative dna helicase
D5085_12970	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
D5085_12980	ENOG4105F1S	paraquat-inducible protein a
D5085_12985	ENOG4105DY2	Paraquat-inducible protein b
D5085_12995	ENOG4105D58	Diguanylate phosphodiesterase
D5085_13005	ENOG4107T0K	Adenylate cyclase
D5085_13010	ENOG4105BZU	Histidine kinase
D5085_13015	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_13020	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_13025	ENOG4105BZU	Histidine kinase
D5085_13030	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
D5085_13035	ENOG4105Q9Y	Universal stress protein
D5085_13045	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
D5085_13065	ENOG4105CE1	Ferrous iron transport protein b
D5085_13095	ENOG4105BZG	amino acid carrier protein
D5085_13100	ENOG4105WH1	Two component transcriptional regulator luxr family
D5085_13105	ENOG4105BZU	Histidine kinase
D5085_13125	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
D5085_13160	ENOG41076HS	cation diffusion facilitator family transporter
D5085_13195	ENOG4105C0H	protease
D5085_13260	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D5085_13270	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
D5085_13295	ENOG4105W5Q	DNA repair protein (RadC
D5085_13300	ENOG4105KJF	protein tyrosine phosphatase
D5085_13315	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5085_13320	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
D5085_13325	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
D5085_13340	ENOG4105CJB	Exodeoxyribonuclease I
D5085_13360	ENOG4105QN4	diheme cytochrome
D5085_13365	ENOG4105C9A	Phoh family
D5085_13370	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
D5085_13375	ENOG4108JU5	Magnesium and cobalt efflux protein
D5085_13380	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
D5085_13395	ENOG41089BK	Glutamine amido-transferase
D5085_13400	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
D5085_13405	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
D5085_13425	ENOG4105C4R	Atp-dependent dna helicase
D5085_13435	ENOG4105RH4	Glycine cleavage system transcriptional repressor
D5085_13455	ENOG4107X2D	transcriptional regulator, merr family
D5085_13460	ENOG4108UJV	acyl-CoA thioesterase i
D5085_13465	ENOG4108I0Y	(ABC) transporter
D5085_13470	ENOG4105CV6	ABC transporter, permease
D5085_13475	ENOG4105C0D	helicase
D5085_13480	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
D5085_13485	ENOG4105EKE	dihydroorotase
D5085_13495	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
D5085_13535	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5085_13545	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
D5085_13550	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D5085_13555	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
D5085_13575	ENOG4105E66	phosphoriboisomerase A
D5085_13580	ENOG4105C7B	Threonine dehydratase
D5085_13585	ENOG4105BZU	Histidine kinase
D5085_13595	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
D5085_13600	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
D5085_13605	ENOG4105C9M	aspartyl-trna synthetase
D5085_13615	ENOG4105E1F	short-chain dehydrogenase reductase
D5085_13625	ENOG4107R88	Chemotaxis protein (CheV)
D5085_13635	ENOG4105D0M	Protease HtpX homolog
D5085_13695	ENOG4105F8J	Adenylate Guanylate cyclase
D5085_13700	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
D5085_13715	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
D5085_13725	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
D5085_13730	ENOG4108YXA	Membrane
D5085_13735	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
D5085_13750	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
D5085_13755	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
D5085_13760	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
D5085_13765	ENOG4105BZU	Histidine kinase
D5085_13775	ENOG4105WH1	Two component transcriptional regulator luxr family
D5085_13780	ENOG4105ENE	Histidine kinase
D5085_13815	ENOG4105C79	DNA protecting protein DprA
D5085_13820	ENOG4108RPN	Protein smg homolog
D5085_13835	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
D5085_13840	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
D5085_13845	ENOG4105CTB	Polyprenyl synthetase
D5085_13850	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
D5085_13860	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
D5085_13865	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
D5085_13885	ENOG4108R96	Methyltransferase, YaeB family
D5085_13895	ENOG4105BZU	Histidine kinase
D5085_13905	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
D5085_13910	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
D5085_13915	ENOG4105CCT	upf0313 protein
D5085_13920	ENOG4105BZU	Histidine kinase
D5085_13925	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
D5085_13930	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
D5085_13935	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
D5085_13940	ENOG4105CVG	Homoserine O-transsuccinylase
D5085_13955	ENOG4105CQB	FAD linked oxidase domain protein
D5085_13960	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
D5085_13965	ENOG41082RQ	UPF0102 protein
D5085_13970	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
D5085_13975	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
D5085_13985	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
D5085_13990	ENOG4105BZA	Phosphoglycerate kinase
D5085_13995	ENOG4105CA9	Pyruvate kinase
D5085_14000	ENOG4105D2N	Aldolase
D5085_14005	ENOG4105C4R	Atp-dependent dna helicase
D5085_14025	ENOG4105VFE	sira family
D5085_14050	ENOG4105KME	endoribonuclease L-psp
D5085_14055	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
D5085_14060	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
D5085_14070	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
D5085_14080	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
D5085_14090	ENOG4105EHV	domain protein
D5085_14095	ENOG4105IH7	synthase
D5085_14150	ENOG4105BZ1	(ABC) transporter
D5085_14155	ENOG4105SG9	biopolymer transport protein, ExbD
D5085_14170	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
D5085_14175	ENOG4105CP9	extracellular ligand-binding receptor
D5085_14185	ENOG4105CNU	cell division protein FtsK
D5085_14190	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_14195	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
D5085_14205	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_14215	ENOG4105EZM	VWA-like domain (DUF2201)
D5085_14225	ENOG4105D44	asparaginase
D5085_14240	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
D5085_14245	ENOG41087SS	fad dependent oxidoreductase
D5085_14250	ENOG4105C28	cystathionine
D5085_14255	ENOG4105ED9	Protein of unknown function (DUF455)
D5085_14260	ENOG4105CPW	cytochrome b561
D5085_14270	ENOG4105DJ0	Poly(A) Polymerase
D5085_14275	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5085_14280	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
D5085_14285	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
D5085_14290	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
D5085_14300	ENOG4105D1F	ATP-binding protein
D5085_14305	ENOG4105BZU	Histidine kinase
D5085_14310	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
D5085_14330	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D5085_14335	ENOG4105C8T	Leucyl-tRNA synthetase
D5085_14340	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
D5085_14345	ENOG4105C3F	Signal peptidase i
D5085_14355	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
D5085_14360	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
D5085_14375	ENOG4108HU6	Metal dependent phosphohydrolase
D5085_14380	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
D5085_14385	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
D5085_14400	ENOG4107QSA	Oxaloacetate decarboxylase
D5085_14405	ENOG4105D9Q	decarboxylase (Beta subunit)
D5085_14410	ENOG41063Z6	transcriptional regulator, lysR family
D5085_14415	ENOG4108MN8	Membrane
D5085_14420	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
D5085_14430	ENOG4108NVR	Methyl-accepting chemotaxis
D5085_14440	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
D5085_14445	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
D5085_14450	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
D5085_14475	ENOG4105E3S	small subunit
D5085_14485	ENOG4108USZ	hydrogenase
D5085_14490	ENOG4105UUH	Domain of unknown function DUF302 
D5085_14500	ENOG4108EC8	DNA internalization-related competence protein ComEC
D5085_14505	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
D5085_14510	ENOG4105C01	Dihydroxy-acid dehydratase
D5085_14515	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_14530	ENOG4108J5G	6-phosphogluconate dehydrogenase
D5085_14535	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
D5085_14540	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
D5085_14550	ENOG4105M00	molybdopterin converting factor, subunit 1
D5085_14555	ENOG4105CM6	amino acid regulated cytosolic protein
D5085_14560	ENOG4106K28	UPF0283 membrane protein
D5085_14570	ENOG4105CH2	amidohydrolase
D5085_14575	ENOG4108JPW	Aminotransferase
D5085_14580	ENOG4105ENR	peptidase, M24
D5085_14590	ENOG4105CDA	abc transporter atp-binding protein
D5085_14605	ENOG4105DRP	amino acid AbC transporter
D5085_14610	ENOG4105EZ7	amino acid ABC transporter
D5085_14620	ENOG4105EYW	Ion transport protein
D5085_14630	ENOG41080IJ	Diacylglycerol kinase
D5085_14640	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
D5085_14645	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
D5085_14650	ENOG4108ZF3	Phosphatase
D5085_14660	ENOG4105DSJ	YicC domain protein
D5085_14670	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
D5085_14675	ENOG4105TX3	Histidine kinase
D5085_14680	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D5085_14690	ENOG4105D6E	homoserine dehydrogenase
D5085_14695	ENOG4105CHM	Aminotransferase
D5085_14735	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
D5085_14740	ENOG4107UZ6	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)
D5085_14745	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
D5085_14750	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
D5085_14755	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D5085_14760	ENOG4108IUZ	ABC transporter
D5085_14775	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
D5085_14780	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
D5085_14785	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
D5085_14790	ENOG4105CE9	30S ribosomal protein S2
D5085_14795	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
D5085_14800	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
D5085_14810	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
D5085_14815	ENOG4105KNE	Phosphatidate cytidylyltransferase
D5085_14820	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
D5085_14825	ENOG4105DZP	Membrane-associated zinc metalloprotease
D5085_14830	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5085_14845	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
D5085_14850	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
D5085_14855	ENOG4105ESI	atpase involved in dna repair
D5085_14860	ENOG4105CB5	ATP-dependent DNA helicase recG
D5085_14865	ENOG4108IV0	ABC, transporter
D5085_14870	ENOG4105C0Z	ABC transporter
D5085_14875	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
D5085_14880	ENOG4105C32	Amino acid ABC transporter (Permease)
D5085_14885	ENOG4105E3A	(ABC) transporter
D5085_14890	ENOG4105DA5	(ABC) transporter
D5085_14905	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
D5085_14910	ENOG4105EZE	Cupin 4 family protein
D5085_14915	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
D5085_14920	ENOG4105BZU	Histidine kinase
D5085_14925	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
D5085_14935	ENOG4105BZU	Histidine kinase
D5085_14940	ENOG4105BZU	Histidine kinase
D5085_14945	ENOG4105BZU	Histidine kinase
D5085_14950	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_14955	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_14970	ENOG4105VFU	Rna-binding protein
D5085_14985	ENOG4108JUA	Transcriptional regulator
D5085_15000	ENOG4108JJA	ABC, transporter
D5085_15010	ENOG4105E9K	Isocitrate dehydrogenase
D5085_15015	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
D5085_15035	ENOG4105CNG	UPF0061 protein
D5085_15045	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_15050	ENOG4105BZU	Histidine kinase
D5085_15060	ENOG4105CFH	Aspartokinase
D5085_15065	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
D5085_15075	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
D5085_15080	ENOG4105BZU	Histidine kinase
D5085_15100	ENOG4105D00	flagellar biosynthetic protein flhB
D5085_15155	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_15160	ENOG4108V3W	Chemotaxis protein, CheW
D5085_15170	ENOG4105CBS	Chea signal transduction histidine kinase
D5085_15180	ENOG4108VYJ	response regulator receiver protein
D5085_15185	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_15190	ENOG4105EHM	Aminoglycoside phosphotransferase
D5085_15205	ENOG4105BZU	Histidine kinase
D5085_15210	ENOG41090R7	Ferric uptake
D5085_15215	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
D5085_15220	ENOG4108Z1B	Cyclase dehydrase
D5085_15225	ENOG4105C8J	)-transporter
D5085_15240	ENOG4108J9M	Transporter
D5085_15265	ENOG4108WWZ	General secretion pathway protein J
D5085_15270	ENOG4105X5Z	General secretion pathway protein I
D5085_15275	ENOG4105VWV	general secretion pathway protein h
D5085_15280	ENOG4108VAU	general secretion pathway protein G
D5085_15285	ENOG4105D7Q	type ii secretion system
D5085_15290	ENOG4107QHF	type ii secretion system protein e
D5085_15295	ENOG4105GVR	general secretion pathway protein D
D5085_15300	ENOG4108XKW	General secretion pathway protein C
D5085_15305	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
D5085_15315	ENOG4105YFD	chemotaxis, protein
D5085_15335	ENOG4105WCA	Ferredoxin
D5085_15345	ENOG4108VQE	nitrogen fixation protein
D5085_15350	ENOG4108UR2	Nitrogen fixation protein NifX
D5085_15355	ENOG4105DK8	Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN
D5085_15360	ENOG4105D0B	Nitrogenase protein alpha chain
D5085_15380	ENOG4105FZE	dinitrogenase iron-molybdenum cofactor biosynthesis
D5085_15385	ENOG4107IVC	4Fe-4S ferredoxin, iron-sulfur binding
D5085_15390	ENOG41084IN	nitrogen fixation protein
D5085_15395	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
D5085_15400	ENOG4105D0B	Nitrogenase protein alpha chain
D5085_15410	ENOG4105C9X	ppx gppa phosphatase
D5085_15420	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_15435	ENOG4105BZU	Histidine kinase
D5085_15445	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_15465	ENOG4108NVR	Methyl-accepting chemotaxis
D5085_15485	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_15530	ENOG4105BZU	Histidine kinase
D5085_15535	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_15540	ENOG4105BZU	Histidine kinase
D5085_15555	ENOG4108W2P	Methyl-accepting chemotaxis
D5085_15570	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
D5085_15575	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
D5085_15585	ENOG4107V1M	polysaccharide export protein
D5085_15605	ENOG4105C8Q	Methyl-accepting chemotaxis
D5085_15625	ENOG4105VFU	Rna-binding protein
D5085_15630	ENOG41075W9	High frequency lysogenization protein HflD homolog
D5085_15635	ENOG4105CHC	glucokinase (EC 2.7.1.2)
D5085_15640	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
D5085_15655	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
D5085_15660	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
D5085_15670	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
D5085_15675	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D5085_15680	ENOG4105M2J	Glutaredoxin
D5085_15685	ENOG4105CDV	Ompa motb domain protein
D5085_15690	ENOG4105C12	Phosphoribosylglycinamide synthetase
D5085_15695	ENOG4105BZU	Histidine kinase
D5085_15705	ENOG4106H78	methyltransferase
D5085_15710	ENOG4105C1V	Peptidase, M16
D5085_15720	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
D5085_15735	ENOG4107XTP	(EAL) domain protein
D5085_15760	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
D5085_15770	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
D5085_15825	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
D5085_15830	ENOG4105GR3	Histidine kinase
D5085_15875	ENOG4105CDV	Ompa motb domain protein
D5085_15895	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D5085_15905	ENOG4105BZU	Histidine kinase
D5085_15910	ENOG4105PWE	CRISPR-associated protein cas2
D5085_15915	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
D5085_15920	ENOG4108Y7V	CRISPR-associated protein, Cse3 family
D5085_15925	ENOG4108VWQ	crispr-associated protein
D5085_15930	ENOG41060M0	Crispr-associated protein, cse4 family
D5085_15995	ENOG4105BZU	Histidine kinase
D5085_16015	ENOG4105K9H	YciI-like protein
D5085_16025	ENOG4107TF3	peptidylprolyl cis-trans isomerase
D5085_16040	ENOG4105CZK	Aspartate kinase
D5085_16050	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
D5085_16055	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
D5085_16060	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
D5085_16070	ENOG4108P4H	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
D5085_16085	ENOG410605C	May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity)
D5085_16095	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
D5085_16100	ENOG4105C3J	Cysteine desulfurase
D5085_16105	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
D5085_16115	ENOG4105VDB	UPF0125 protein
D5085_16120	ENOG4108E8M	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
D5085_16125	ENOG4108UQQ	Electron transport complex
D5085_16130	ENOG4105D6A	Electron transport complex
D5085_16135	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
D5085_16140	ENOG4108R3D	Electron transport complex
D5085_16145	ENOG4105DGN	Electron transport complex
D5085_16150	ENOG4105DS4	PAS PAC sensor Signal transduction histidine kinase
D5085_16155	ENOG4108JUA	Transcriptional regulator
D5085_16210	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
D5085_16215	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
D5085_16220	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
D5085_16250	ENOG4105BZU	Histidine kinase
D5085_16255	ENOG4105BZU	Histidine kinase
D5085_16260	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_16265	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
D5085_16270	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
D5085_16275	ENOG4107QMS	site-determining protein
D5085_16280	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
D5085_16285	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
D5085_16290	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
D5085_16295	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
D5085_16315	ENOG4105I03	Flagellin
D5085_16320	ENOG4105CRE	cytochrome C
D5085_16325	ENOG4108JU6	CBS domain protein
D5085_16350	ENOG4105BZU	Histidine kinase
D5085_16360	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_16370	ENOG4105BZU	Histidine kinase
D5085_16380	ENOG4105BZU	Histidine kinase
D5085_16385	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_16390	ENOG4105BZU	Histidine kinase
D5085_16405	ENOG4105SFS	phosphoesterase RecJ domain protein
D5085_16410	ENOG4105EIN	peptidylprolyl cis-trans isomerase
D5085_16425	ENOG4105K70	DNA-binding protein
D5085_16430	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
D5085_16435	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
D5085_16440	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
D5085_16445	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
D5085_16455	ENOG4106VK6	Flagellar motor protein
D5085_16460	ENOG4105E14	MotA TolQ exbB proton channel
D5085_16465	ENOG4105MPD	Cytochrome
D5085_16475	ENOG4105CXT	aspartate transcarbamylase
D5085_16480	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
D5085_16490	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
D5085_16495	ENOG4105CH7	arginosuccinase
D5085_16500	ENOG4105DHZ	alpha beta
D5085_16510	ENOG4105WH1	Two component transcriptional regulator luxr family
D5085_16515	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
D5085_16520	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5085_16525	ENOG4107MKT	Stringent starvation protein a
D5085_16530	ENOG4105DHP	deoxycytidine triphosphate deaminase
D5085_16535	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
D5085_16580	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
D5085_16585	ENOG4105BZU	Histidine kinase
D5085_16595	ENOG4105BZU	Histidine kinase
D5085_16610	ENOG4105BZU	Histidine kinase
D5085_16615	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
D5085_16620	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
D5085_16625	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
D5085_16630	ENOG4105CJW	magnesium transporter
D5085_16645	ENOG4108JYK	Dehydrogenase
D5085_16650	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
D5085_16655	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
D5085_16665	ENOG4105EPW	hflc protein
D5085_16670	ENOG4107QJR	hflk protein
D5085_16680	ENOG4105CHM	Aminotransferase
D5085_16685	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
D5085_16690	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
D5085_16695	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
D5085_16700	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_16710	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
D5085_16730	ENOG4105ESI	atpase involved in dna repair
D5085_16735	ENOG4105CB5	ATP-dependent DNA helicase recG
D5085_16740	ENOG4105C0D	helicase
D5085_16770	ENOG4105XQ6	frataxin-like protein
D5085_16780	ENOG4107QZV	Type I secretion membrane fusion protein
D5085_16785	ENOG4108JJA	ABC, transporter
D5085_16790	ENOG4105DFG	type I secretion outer membrane protein
D5085_16795	ENOG4105F8J	Adenylate Guanylate cyclase
D5085_16805	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
D5085_16810	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
D5085_16815	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
D5085_16820	ENOG4105C8Y	Acetylornithine aminotransferase
D5085_16825	ENOG4105DBV	ornithine carbamoyltransferase
D5085_16840	ENOG41090A4	Pterin carbinolamine dehydratase
D5085_16850	ENOG4105BZ8	glutamate synthase
D5085_16855	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_16860	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_16865	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D5085_16870	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
D5085_16875	ENOG4108JPZ	Monovalent cation H antiporter subunit D
D5085_16880	ENOG4108ZE9	Monovalent cation H antiporter subunit C
D5085_16885	ENOG4105HC0	Na H antiporter
D5085_16900	ENOG410684G	monovalent cation H antiporter subunit F
D5085_16925	ENOG4105CUW	cytochrome C-TYPE protein
D5085_16930	ENOG4105MW3	Cytochrome
D5085_16935	ENOG4107S7U	Sulfide dehydrogenase
D5085_16940	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
D5085_16950	ENOG4105CHW	UPF0052 protein
D5085_17000	ENOG4108JJ7	ABC transporter
D5085_17010	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
D5085_17015	ENOG4105FBD	synthase
D5085_17020	ENOG4105FE1	phytoene synthase
D5085_17025	ENOG4107S11	squalene-associated FAD-dependent desaturase
D5085_17030	ENOG4105UBK	short-chain dehydrogenase reductase
D5085_17035	ENOG4105BZU	Histidine kinase
D5085_17040	ENOG4105CFV	Tetratricopeptide repeat protein
D5085_17045	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
D5085_17050	ENOG4105CAT	Cytidine monophosphate kinase
D5085_17055	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
D5085_17065	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
D5085_17070	ENOG4105CIH	Imidazole acetol-phosphate transaminase
D5085_17080	ENOG4108JQ1	Dehydrogenase
D5085_17085	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
D5085_17090	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D5085_17095	ENOG4105KB2	stringent starvation protein b
D5085_17100	ENOG4107MKT	Stringent starvation protein a
D5085_17105	ENOG4105EIX	cytochrome c1
D5085_17110	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
D5085_17115	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
D5085_17120	ENOG4107QNR	UPF0135 protein
D5085_17135	ENOG4105BZU	Histidine kinase
D5085_17140	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
D5085_17150	ENOG4105RQ9	TPR repeat-containing protein
D5085_17170	ENOG4107S90	membrAne
D5085_17185	ENOG4105F8J	Adenylate Guanylate cyclase
D5085_17200	ENOG41090HT	Inherit from COG: transposase
D5085_17215	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
D5085_17220	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
D5085_17230	ENOG4105BZU	Histidine kinase
D5085_17235	ENOG4105BZU	Histidine kinase
D5085_17240	ENOG4108ZXC	Two component transcriptional regulator, luxr family
D5085_17245	ENOG4108VYJ	response regulator receiver protein
D5085_17250	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
D5085_17275	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D5085_17280	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D5085_17290	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_17295	ENOG4107STW	synthase
D5085_17310	ENOG4108VYJ	response regulator receiver protein
D5085_17315	ENOG4107GFK	fumarate
D5085_17320	ENOG4105BZU	Histidine kinase
D5085_17335	ENOG4105C59	p-type ATPase
D5085_17350	ENOG4105C1G	acyl-Coa dehydrogenase
D5085_17360	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
D5085_17375	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
D5085_17385	ENOG4105C6T	cysteine synthase
D5085_17390	ENOG4108YZY	peptidylprolyl cis-trans isomerase
D5085_17415	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
D5085_17425	ENOG4105VUH	addiction module killer protein
D5085_17430	ENOG4105YES	addiction module antidote protein
D5085_17440	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
D5085_17465	ENOG4105BZU	Histidine kinase
D5085_17470	ENOG4105WH1	Two component transcriptional regulator luxr family
D5085_17485	ENOG4108JJ6	Type I secretion system ATPase
D5085_17545	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
D5085_17555	ENOG4105C03	ribonuclease
D5085_17560	ENOG4108Z03	MAF-like protein
D5085_17565	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
D5085_17575	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
D5085_17585	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
D5085_17610	ENOG4108I0Z	Aconitate hydratase
D5085_17615	ENOG4105BZN	citrate synthase
D5085_17635	ENOG4105BZS	acriflavin resistance protein
D5085_17640	ENOG4108V8F	Transcriptional regulator, MarR family
D5085_17650	ENOG4108JPW	Aminotransferase
D5085_17655	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
D5085_17670	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
D5085_17675	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
D5085_17680	ENOG4105CAQ	asparagine synthetase
D5085_17695	ENOG4108JPV	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
D5085_17700	ENOG4105DHT	Metal Dependent Phosphohydrolase
D5085_17705	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
D5085_17710	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
D5085_17720	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
D5085_17745	ENOG4105ECP	epimerase
D5085_17800	ENOG4108RTD	type II secretion system protein K
D5085_17815	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5085_17820	ENOG4105CFG	Acts as a chaperone (By similarity)
D5085_17840	ENOG4108UPT	UPF0178 protein
D5085_17845	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
D5085_17850	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
D5085_17860	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
D5085_17865	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
D5085_17870	ENOG4105BZU	Histidine kinase
D5085_17885	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D5085_17890	ENOG4108K5P	(LipO)protein
D5085_17895	ENOG4108UM1	dedA family
D5085_17900	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
D5085_17905	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
D5085_17920	ENOG4105D7Q	type ii secretion system
D5085_17930	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
D5085_17935	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
D5085_17940	ENOG4105KJM	monovalent cation h antiporter subunit g
D5085_17945	ENOG4105W4C	monovalent cation H antiporter subunit F
D5085_17950	ENOG4105SC1	monovalent cation H antiporter subunit E
D5085_17955	ENOG4107R4Z	monovalent cation h antiporter subunit d
D5085_17960	ENOG4108ZE9	Monovalent cation H antiporter subunit C
D5085_17965	ENOG4105D65	subunit l
D5085_17970	ENOG4107QW3	Sucrose phosphorylase
D5085_17975	ENOG4105C3Q	Glycosyl transferase, family 2
D5085_18025	ENOG4105DTN	riboflavin biosynthesis protein ribF
D5085_18030	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
D5085_18040	ENOG4105C9U	ATP-dependent DNA helicase RecQ
D5085_18085	ENOG4105E7D	Protein of unknown function (DUF3375)
D5085_18105	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
D5085_18110	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
D5085_18115	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
D5085_18120	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
D5085_18125	ENOG4105E2Z	phosphate ABC transporter (Permease
D5085_18130	ENOG4105C8U	phosphate abc transporter
D5085_18135	ENOG4107T3P	ABC, transporter
D5085_18160	ENOG4105FAE	von Willebrand factor, type A
D5085_18165	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D5085_18185	ENOG4105CHM	Aminotransferase
D5085_18190	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
D5085_18200	ENOG4105VFE	sira family
D5085_18205	ENOG4105BZM	domain protein
D5085_18215	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
D5085_18220	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
D5085_18240	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
D5085_18245	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
D5085_18250	ENOG4105BZU	Histidine kinase
D5085_18255	ENOG4105BZU	Histidine kinase
D5085_18260	ENOG41086B8	CoB-CoM heterodisulfide reductase
D5085_18265	ENOG4105E33	succinate dehydrogenase
D5085_18275	ENOG4105EWK	phytoene
D5085_18280	ENOG4105EAH	synthase
D5085_18315	ENOG4105C5F	glutamine synthetase
D5085_18320	ENOG4105CUX	Signal transduction histidine kinase
D5085_18325	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
D5085_18350	ENOG4105DHT	Metal Dependent Phosphohydrolase
D5085_18365	ENOG4105D7Z	glutathione synthase
D5085_18465	ENOG4108ECM	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity)
D5085_18470	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
D5085_18475	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
D5085_18480	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
D5085_18485	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
D5085_18490	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
D5085_18495	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
D5085_18510	ENOG4105CDH	Citrulline--aspartate ligase
D5085_18515	ENOG4105BZU	Histidine kinase
D5085_18520	ENOG4108UKZ	OsmC family
D5085_18525	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
D5085_18530	ENOG4108Z6B	deaminase
D5085_18535	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D5085_18540	ENOG4108SVW	integral membrane protein
D5085_18560	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
D5085_18565	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
D5085_18570	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
D5085_18575	ENOG4105M6F	mutator MutT protein
D5085_18580	ENOG4105D1Q	UPF0246 protein
D5085_18595	ENOG4105WH1	Two component transcriptional regulator luxr family
D5085_18620	ENOG4105BZS	acriflavin resistance protein
D5085_18635	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
D5085_18640	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
D5085_18645	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
D5085_18650	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
D5085_18655	ENOG41082NX	50s ribosomal protein l35
D5085_18660	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
D5085_18665	ENOG4105C22	threonyL-tRNA synthetase
D5085_18685	ENOG4105K63	Thioredoxin
D5085_18690	ENOG4105F8J	Adenylate Guanylate cyclase
D5085_18695	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
D5085_18700	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
D5085_18710	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
D5085_18715	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
D5085_18725	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
D5085_18735	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D5085_18745	ENOG4107QN1	sodium solute