locus-tag	class	description
D5085_00020	COG4467	Involved in initiation control of chromosome replication
D5085_00030	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D5085_00035	COG1222	aaa ATPase
D5085_00060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5085_00100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5085_00105	COG4221	oxidoreductase activity
D5085_00105	COG0300	oxidoreductase activity
D5085_00105	COG3321	synthase
D5085_00105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5085_00115	COG2070	2-Nitropropane dioxygenase
D5085_00115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5085_00145	COG1132	(ABC) transporter
D5085_00150	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_00155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_00160	COG0513	Belongs to the DEAD box helicase family
D5085_00170	COG2153	protein acetylation
D5085_00195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5085_00240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_00305	COG4717	serine-type aminopeptidase activity
D5085_00310	COG0420	3'-5' exonuclease activity
D5085_00315	COG1690	Belongs to the RtcB family
D5085_00320	COG3577	Aspartyl protease
D5085_00355	COG0058	SHG alpha-glucan phosphorylase activity
D5085_00360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D5085_00365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5085_00400	COG2210	Belongs to the sulfur carrier protein TusA family
D5085_00405	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_00410	COG1309	transcriptional regulator
D5085_00415	COG3706	GGDEF domain
D5085_00420	COG2962	Rard protein
D5085_00440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_00445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5085_00455	COG0303	'Molybdopterin
D5085_00460	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5085_00465	COG2197	response regulator
D5085_00470	COG3850	Histidine kinase
D5085_00480	COG2223	nitrite transmembrane transporter activity
D5085_00485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D5085_00495	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D5085_00500	COG2181	nitrate reductase activity
D5085_00505	COG2920	part of a sulfur-relay system
D5085_00510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5085_00515	COG0288	reversible hydration of carbon dioxide
D5085_00520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_00580	COG3344	reverse transcriptase
D5085_00590	COG0494	nUDIX hydrolase
D5085_00595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5085_00600	COG1074	ATP-dependent DNA helicase activity
D5085_00605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_00720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_00730	COG2801	Transposase and inactivated derivatives
D5085_00730	COG3415	Transposase
D5085_00755	COG3436	PFAM IS66 Orf2 family protein
D5085_00810	COG4804	nuclease activity
D5085_00815	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D5085_00845	COG0210	DNA helicase
D5085_00895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5085_00915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5085_00915	COG0085	RNA polymerase activity
D5085_00915	COG0085	RNA polymerase activity
D5085_00915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5085_01025	COG3436	PFAM IS66 Orf2 family protein
D5085_01060	COG0705	Rhomboid family
D5085_01075	COG1199	ATP-dependent helicase activity
D5085_01080	COG0629	single-stranded DNA binding
D5085_01170	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D5085_01235	COG1136	(ABC) transporter
D5085_01300	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5085_01305	COG2863	cytochrome
D5085_01330	COG0315	cyclic pyranopterin monophosphate synthase activity
D5085_01350	COG0746	molybdenum cofactor guanylyltransferase activity
D5085_01355	COG0840	transmembrane signaling receptor activity
D5085_01375	COG2010	Cytochrome c
D5085_01400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5085_01475	COG2105	PFAM AIG2 family protein
D5085_01495	COG1254	Belongs to the acylphosphatase family
D5085_01510	COG0393	Putative heavy-metal-binding
D5085_01560	COG1595	DNA-templated transcription, initiation
D5085_01590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5085_01605	COG0457	Tetratricopeptide repeat
D5085_01615	COG2867	negative regulation of translational initiation
D5085_01675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D5085_01690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5085_01695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5085_01705	COG1490	D-aminoacyl-tRNA deacylase activity
D5085_01715	COG1053	succinate dehydrogenase
D5085_01720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_01725	COG1256	bacterial-type flagellum assembly
D5085_01745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5085_01745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5085_01750	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5085_01765	COG1420	regulation of RNA biosynthetic process
D5085_01770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5085_01775	COG0443	Heat shock 70 kDa protein
D5085_01780	COG0484	heat shock protein binding
D5085_01785	COG0482	sulfurtransferase activity
D5085_01790	COG0840	transmembrane signaling receptor activity
D5085_01845	COG0280	phosphate acetyltransferase
D5085_01845	COG0857	belongs to the CobB CobQ family
D5085_01850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5085_01885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_01895	COG0802	atpase or kinase
D5085_01905	COG4174	ABC transporter (Permease)
D5085_01910	COG4166	transmembrane transport
D5085_01915	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D5085_01925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5085_01930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5085_01935	COG1862	Preprotein translocase
D5085_01945	COG4232	protein-disulfide reductase activity
D5085_01955	COG2920	part of a sulfur-relay system
D5085_01975	COG2221	Nitrite and sulphite reductase 4Fe-4S
D5085_01985	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D5085_01990	COG2923	Belongs to the DsrF TusC family
D5085_01995	COG2168	tRNA wobble position uridine thiolation
D5085_02000	COG2920	part of a sulfur-relay system
D5085_02035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5085_02040	COG1797	cobyrinic acid a,c-diamide synthase activity
D5085_02045	COG1216	Glycosyl transferase, family 2
D5085_02050	COG0463	Glycosyl transferase, family 2
D5085_02080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5085_02135	COG1216	Glycosyl transferase, family 2
D5085_02135	COG0438	transferase activity, transferring glycosyl groups
D5085_02235	COG3436	PFAM IS66 Orf2 family protein
D5085_02250	COG3386	PFAM SMP-30 Gluconolaconase
D5085_02315	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_02320	COG3657	addiction module killer protein
D5085_02355	COG2944	sequence-specific DNA binding
D5085_02385	COG2944	sequence-specific DNA binding
D5085_02395	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5085_02410	COG3436	PFAM IS66 Orf2 family protein
D5085_02425	COG1216	Glycosyl transferase, family 2
D5085_02430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_02465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_02505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_02530	COG1166	arginine decarboxylase activity
D5085_02535	COG0135	phosphoribosylanthranilate isomerase activity
D5085_02540	COG0159	tryptophan synthase activity
D5085_02550	COG1834	amidinotransferase
D5085_02555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5085_02580	COG0149	triose-phosphate isomerase activity
D5085_02585	COG1160	GTP binding
D5085_02595	COG2976	Protein conserved in bacteria
D5085_02600	COG0124	histidyl-tRNA synthetase
D5085_02610	COG1426	Protein conserved in bacteria
D5085_02620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5085_02635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5085_02665	COG3267	Type II secretory pathway component ExeA
D5085_02665	COG3409	Peptidoglycan-binding domain 1 protein
D5085_02680	COG0587	DNA-directed DNA polymerase activity
D5085_02775	COG4983	Phage plasmid primase, P4 family domain protein
D5085_02805	COG1403	HNH endonuclease
D5085_02810	COG0205	6-phosphofructokinase activity
D5085_02815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5085_02820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5085_02825	COG5002	protein histidine kinase activity
D5085_02825	COG0784	Response regulator, receiver
D5085_02825	COG2205	protein histidine kinase activity
D5085_02835	COG1067	ATP-dependent peptidase activity
D5085_02840	COG0488	(ABC) transporter
D5085_02850	COG0390	transport system, permease component
D5085_02855	COG4619	ABC transporter
D5085_02865	COG1187	pseudouridine synthase activity
D5085_02870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5085_02875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5085_02880	COG0180	Tryptophanyl-tRNA synthetase
D5085_02885	COG1994	Peptidase M50
D5085_02890	COG0009	L-threonylcarbamoyladenylate synthase
D5085_02895	COG0613	PHP domain protein
D5085_02910	COG0071	Belongs to the small heat shock protein (HSP20) family
D5085_02915	COG1238	metal cluster binding
D5085_02920	COG0784	Response regulator, receiver
D5085_02920	COG2205	protein histidine kinase activity
D5085_02920	COG5002	protein histidine kinase activity
D5085_02955	COG2201	protein-glutamate methylesterase activity
D5085_02965	COG0546	phosphoglycolate phosphatase activity
D5085_02965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5085_02985	COG2270	Major facilitator Superfamily
D5085_03015	COG0217	transcriptional regulatory protein
D5085_03055	COG1666	GTP binding
D5085_03060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5085_03065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5085_03070	COG5001	Diguanylate cyclase
D5085_03070	COG3300	MHYT domain
D5085_03080	COG1917	Cupin 2, conserved barrel domain protein
D5085_03090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5085_03100	COG2363	Small membrane protein
D5085_03120	COG3093	addiction module antidote protein HigA
D5085_03125	COG3549	Plasmid maintenance system killer
D5085_03145	COG0840	transmembrane signaling receptor activity
D5085_03150	COG2201	protein-glutamate methylesterase activity
D5085_03155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5085_03160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5085_03165	COG0840	transmembrane signaling receptor activity
D5085_03170	COG0835	chemotaxis
D5085_03175	COG2198	Histidine kinase
D5085_03175	COG0643	Histidine kinase
D5085_03180	COG0745	RESPONSE REGULATOR receiver
D5085_03185	COG1192	Involved in chromosome partitioning
D5085_03220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5085_03235	COG0084	hydrolase, TatD family'
D5085_03245	COG0784	Response regulator, receiver
D5085_03245	COG0835	chemotaxis
D5085_03255	COG4191	Histidine kinase
D5085_03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5085_03260	COG3437	response regulator, receiver
D5085_03260	COG0784	Response regulator, receiver
D5085_03330	COG0284	orotidine-5'-phosphate decarboxylase activity
D5085_03335	COG0784	Response regulator, receiver
D5085_03335	COG2205	protein histidine kinase activity
D5085_03335	COG5002	protein histidine kinase activity
D5085_03345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5085_03365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5085_03370	COG0840	transmembrane signaling receptor activity
D5085_03400	COG3706	GGDEF domain
D5085_03420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5085_03420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D5085_03425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5085_03430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5085_03435	COG0509	glycine decarboxylation via glycine cleavage system
D5085_03440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5085_03445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5085_03450	COG0784	Response regulator, receiver
D5085_03450	COG5002	protein histidine kinase activity
D5085_03450	COG2205	protein histidine kinase activity
D5085_03455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5085_03460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5085_03465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5085_03495	COG1643	Atp-dependent helicase
D5085_03505	COG3706	GGDEF domain
D5085_03510	COG0617	tRNA 3'-terminal CCA addition
D5085_03515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5085_03520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5085_03525	COG0469	pyruvate kinase activity
D5085_03535	COG0019	diaminopimelate decarboxylase activity
D5085_03550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5085_03560	COG0701	Predicted permease
D5085_03575	COG1595	DNA-templated transcription, initiation
D5085_03595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5085_03600	COG1047	Peptidyl-prolyl cis-trans
D5085_03605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5085_03615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5085_03635	COG1592	Rubrerythrin
D5085_03640	COG0840	transmembrane signaling receptor activity
D5085_03645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5085_03650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D5085_03670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5085_03680	COG2226	methyltransferase
D5085_03695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5085_03700	COG0525	valine-tRNA ligase activity
D5085_03705	COG2326	polyphosphate kinase activity
D5085_03715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5085_03720	COG0154	amidase activity
D5085_03725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5085_03730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5085_03740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5085_03745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5085_03750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5085_03760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5085_03765	COG2918	glutathione biosynthetic process
D5085_03805	COG0367	asparagine synthase
D5085_03815	COG2226	methyltransferase
D5085_03825	COG0110	maltose O-acetyltransferase activity
D5085_03830	COG2226	methyltransferase
D5085_03895	COG0432	Pfam Uncharacterised protein family UPF0047
D5085_03905	COG3437	response regulator, receiver
D5085_03925	COG0606	chelatase, subunit chli
D5085_03935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D5085_03955	COG1560	Kdo2-lipid A biosynthetic process
D5085_03975	COG4636	protein conserved in cyanobacteria
D5085_04025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_04050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_04055	COG4249	Peptidase C14 caspase catalytic subunit p20
D5085_04055	COG2319	Wd-40 repeat
D5085_04065	COG2319	Wd-40 repeat
D5085_04065	COG4249	Peptidase C14 caspase catalytic subunit p20
D5085_04110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_04160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_04185	COG0745	RESPONSE REGULATOR receiver
D5085_04235	COG0519	Catalyzes the synthesis of GMP from XMP
D5085_04295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5085_04305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5085_04310	COG1686	Belongs to the peptidase S11 family
D5085_04315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5085_04320	COG2951	lytic endotransglycosylase activity
D5085_04325	COG0772	Belongs to the SEDS family
D5085_04330	COG0768	penicillin binding
D5085_04335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D5085_04340	COG1792	Involved in formation and maintenance of cell shape
D5085_04345	COG1077	Cell shape determining protein MreB Mrl
D5085_04355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5085_04370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5085_04380	COG0730	response to heat
D5085_04395	COG2223	nitrite transmembrane transporter activity
D5085_04400	COG1858	cytochrome C peroxidase
D5085_04405	COG0492	ferredoxin-NADP+ reductase activity
D5085_04410	COG2199	diguanylate cyclase activity
D5085_04410	COG2200	EAL domain
D5085_04415	COG3706	GGDEF domain
D5085_04415	COG0745	RESPONSE REGULATOR receiver
D5085_04425	COG0825	malonyl-CoA metabolic process
D5085_04430	COG4239	(ABC) transporter, permease
D5085_04435	COG0493	'glutamate synthase
D5085_04440	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5085_04445	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5085_04470	COG3072	Adenylate cyclase
D5085_04480	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_04485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5085_04530	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D5085_04605	COG3436	PFAM IS66 Orf2 family protein
D5085_04625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_04760	COG3842	ATPase activity
D5085_04805	COG0735	belongs to the Fur family
D5085_04810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5085_04815	COG1121	(ABC) transporter
D5085_04865	COG0045	succinate-CoA ligase (ADP-forming) activity
D5085_04870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5085_04885	COG0741	lytic transglycosylase activity
D5085_04895	COG2046	Belongs to the sulfate adenylyltransferase family
D5085_04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5085_04920	COG0445	tRNA wobble uridine modification
D5085_04925	COG0357	Ribosomal RNA small subunit methyltransferase G
D5085_04930	COG1192	Involved in chromosome partitioning
D5085_04935	COG1475	DNA binding
D5085_04940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5085_04950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5085_04955	COG0706	membrane insertase activity
D5085_04960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5085_04980	COG2202	Pas domain
D5085_04980	COG2205	protein histidine kinase activity
D5085_05020	COG1598	PFAM Uncharacterised protein family UPF0150
D5085_05045	COG0859	PFAM glycosyl transferase family 9
D5085_05050	COG0859	PFAM glycosyl transferase family 9
D5085_05055	COG0438	transferase activity, transferring glycosyl groups
D5085_05085	COG3954	Phosphoribulokinase
D5085_05090	COG4953	penicillin-binding protein 1C
D5085_05105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5085_05120	COG1088	dTDP-glucose 4,6-dehydratase activity
D5085_05125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5085_05130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5085_05145	COG2221	Nitrite and sulphite reductase 4Fe-4S
D5085_05150	COG1678	Uncharacterized ACR, COG1678
D5085_05155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5085_05165	COG2210	Belongs to the sulfur carrier protein TusA family
D5085_05170	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_05175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_05185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5085_05190	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5085_05195	COG0203	ribosomal protein L17
D5085_05200	COG0202	RNA polymerase activity
D5085_05205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5085_05210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5085_05215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5085_05225	COG0201	protein transport
D5085_05230	COG0200	Binds to the 23S rRNA
D5085_05235	COG1841	ribosomal large subunit assembly
D5085_05240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5085_05245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D5085_05250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5085_05255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D5085_05260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5085_05265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5085_05270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D5085_05275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5085_05285	COG0255	Belongs to the universal ribosomal protein uL29 family
D5085_05290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5085_05295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5085_05300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5085_05305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5085_05310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5085_05315	COG0089	rRNA binding
D5085_05320	COG0088	Forms part of the polypeptide exit tunnel
D5085_05325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5085_05330	COG0051	transcription antitermination factor activity, RNA binding
D5085_05335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5085_05340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5085_05345	COG0049	tRNA binding
D5085_05360	COG0085	RNA polymerase activity
D5085_05365	COG0222	ribosome binding
D5085_05370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5085_05380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5085_05390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5085_05400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5085_05425	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5085_05470	COG0784	Response regulator, receiver
D5085_05470	COG2205	protein histidine kinase activity
D5085_05470	COG5002	protein histidine kinase activity
D5085_05480	COG3437	response regulator, receiver
D5085_05570	COG3220	belongs to the UPF0276 family
D5085_05605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5085_05610	COG0440	acetolactate synthase activity
D5085_05615	COG0028	Belongs to the TPP enzyme family
D5085_05620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5085_05625	COG0840	transmembrane signaling receptor activity
D5085_05630	COG3290	protein histidine kinase activity
D5085_05630	COG0840	transmembrane signaling receptor activity
D5085_05680	COG0589	response to stress
D5085_05685	COG0659	secondary active sulfate transmembrane transporter activity
D5085_05690	COG0668	transmembrane transport
D5085_05705	COG0456	acetyltransferase
D5085_05710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5085_05715	COG3773	Cell wall hydrolase
D5085_05715	COG3409	Peptidoglycan-binding domain 1 protein
D5085_05720	COG2983	Belongs to the UPF0260 family
D5085_05745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5085_05755	COG1136	(ABC) transporter
D5085_05760	COG4591	ABC-type transport system involved in lipoprotein release permease component
D5085_05765	COG4172	Belongs to the ABC transporter superfamily
D5085_05795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5085_05870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5085_05875	COG0156	8-amino-7-oxononanoate synthase activity
D5085_05890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D5085_05915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5085_05930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5085_05945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5085_05945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5085_05950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5085_05955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5085_06030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5085_06040	COG2201	protein-glutamate methylesterase activity
D5085_06065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5085_06070	COG1648	precorrin-2 dehydrogenase activity
D5085_06070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5085_06090	COG3118	belongs to the thioredoxin family
D5085_06095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5085_06175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5085_06195	COG1538	Outer membrane efflux protein
D5085_06200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5085_06205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D5085_06220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5085_06240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D5085_06250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_06255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_06260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_06270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5085_06270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5085_06275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5085_06305	COG1088	dTDP-glucose 4,6-dehydratase activity
D5085_06315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5085_06340	COG1032	radical SAM domain protein
D5085_06345	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D5085_06365	COG3958	Transketolase
D5085_06370	COG3959	Transketolase, thiamine diphosphate binding domain
D5085_06375	COG1088	dTDP-glucose 4,6-dehydratase activity
D5085_06420	COG2089	acid synthase
D5085_06425	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D5085_06435	COG1012	belongs to the aldehyde dehydrogenase family
D5085_06450	COG4310	Domain of unknown function (DUF2172)
D5085_06455	COG1083	cytidylyl-transferase
D5085_06460	COG1086	Polysaccharide biosynthesis protein
D5085_06505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5085_06515	COG0546	phosphoglycolate phosphatase activity
D5085_06520	COG0564	pseudouridine synthase activity
D5085_06525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5085_06530	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_06530	COG3347	Dehydrogenase
D5085_06535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5085_06540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5085_06545	COG2835	tetraacyldisaccharide 4'-kinase activity
D5085_06550	COG1663	tetraacyldisaccharide 4'-kinase activity
D5085_06555	COG1177	transmembrane transport
D5085_06560	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5085_06565	COG3842	ATPase activity
D5085_06575	COG2967	ApaG domain
D5085_06580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5085_06585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5085_06590	COG1530	ribonuclease E activity
D5085_06605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5085_06615	COG2890	protein-(glutamine-N5) methyltransferase activity
D5085_06620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5085_06625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5085_06645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5085_06650	COG0739	heme binding
D5085_06665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5085_06670	COG0416	fatty acid biosynthetic process
D5085_06675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5085_06680	COG1399	metal-binding, possibly nucleic acid-binding protein
D5085_06685	COG0424	maF-like protein
D5085_06705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5085_06720	COG1040	competence protein
D5085_06725	COG1196	nuclear chromosome segregation
D5085_06760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5085_06770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5085_06785	COG0352	thiamine-phosphate diphosphorylase activity
D5085_06785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D5085_06785	COG0351	phosphomethylpyrimidine kinase
D5085_06820	COG0442	prolyl-tRNA aminoacylation
D5085_06855	COG3005	denitrification pathway
D5085_06925	COG3005	denitrification pathway
D5085_07070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5085_07075	COG0210	DNA helicase
D5085_07090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5085_07100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5085_07130	COG3012	SEC-C Motif Domain Protein
D5085_07205	COG2837	iron assimilation
D5085_07215	COG3321	synthase
D5085_07215	COG0604	alcohol dehydrogenase
D5085_07220	COG0228	four-way junction DNA binding
D5085_07225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5085_07230	COG0336	Belongs to the RNA methyltransferase TrmD family
D5085_07235	COG0335	large ribosomal subunit rRNA binding
D5085_07250	COG4974	Belongs to the 'phage' integrase family
D5085_07275	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5085_07290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_07305	COG1610	YqeY-like protein
D5085_07310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5085_07320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5085_07325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5085_07330	COG0537	adenosine 5'-monophosphoramidase activity
D5085_07335	COG0140	phosphoribosyl-ATP diphosphatase activity
D5085_07340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5085_07345	COG0107	imidazoleglycerol-phosphate synthase activity
D5085_07350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5085_07355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5085_07360	COG0131	Imidazoleglycerol-phosphate dehydratase
D5085_07370	COG1765	OsmC-like protein
D5085_07430	COG3541	Predicted nucleotidyltransferase
D5085_07440	COG3541	Predicted nucleotidyltransferase
D5085_07460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_07515	COG0210	DNA helicase
D5085_07535	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5085_07590	COG0732	type I restriction modification DNA specificity domain
D5085_07630	COG3436	PFAM IS66 Orf2 family protein
D5085_07660	COG3541	Predicted nucleotidyltransferase
D5085_07690	COG4467	Involved in initiation control of chromosome replication
D5085_07755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_07760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5085_07800	COG4467	Involved in initiation control of chromosome replication
D5085_07840	COG1518	maintenance of DNA repeat elements
D5085_07850	COG2814	Major facilitator Superfamily
D5085_07855	COG3384	dioxygenase
D5085_07870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5085_07875	COG0653	protein targeting
D5085_07880	COG0739	heme binding
D5085_07890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D5085_07895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5085_07915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5085_07920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5085_07925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5085_07930	COG0772	Belongs to the SEDS family
D5085_07935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5085_07940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5085_07945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5085_07950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5085_07960	COG3116	cell division
D5085_07965	COG0275	rRNA processing
D5085_07970	COG2001	Belongs to the MraZ family
D5085_07990	COG0714	Associated with various cellular activities
D5085_07995	COG0543	2 iron, 2 sulfur cluster binding
D5085_07995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5085_08000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5085_08005	COG0569	domain protein
D5085_08015	COG3302	dmso reductase anchor subunit
D5085_08020	COG0437	4 iron, 4 sulfur cluster binding
D5085_08025	COG0243	molybdopterin cofactor binding
D5085_08040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_08045	COG0187	DNA topoisomerase II activity
D5085_08050	COG0018	arginyl-trna synthetase
D5085_08055	COG1741	Belongs to the pirin family
D5085_08075	COG0751	glycine-tRNA ligase activity
D5085_08085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5085_08090	COG0628	permease
D5085_08110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5085_08115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5085_08125	COG3267	Type II secretory pathway component ExeA
D5085_08125	COG3409	Peptidoglycan-binding domain 1 protein
D5085_08165	COG3555	Aspartyl Asparaginyl beta-hydroxylase
D5085_08175	COG0138	bifunctional purine biosynthesis protein purh
D5085_08220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D5085_08225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5085_08230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D5085_08240	COG0512	Glutamine amidotransferase of anthranilate synthase
D5085_08245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5085_08250	COG0134	indole-3-glycerol-phosphate synthase activity
D5085_08255	COG0483	inositol monophosphate 1-phosphatase activity
D5085_08270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5085_08290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5085_08295	COG1923	regulation of RNA biosynthetic process
D5085_08300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5085_08305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5085_08325	COG3850	Histidine kinase
D5085_08325	COG2205	protein histidine kinase activity
D5085_08325	COG3437	response regulator, receiver
D5085_08325	COG4999	Histidine kinase
D5085_08350	COG4636	protein conserved in cyanobacteria
D5085_08365	COG3128	pkhd-type hydroxylase
D5085_08370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5085_08395	COG1902	pentaerythritol trinitrate reductase activity
D5085_08400	COG2814	Major facilitator Superfamily
D5085_08425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5085_08435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5085_08440	COG0546	phosphoglycolate phosphatase activity
D5085_08445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5085_08450	COG0415	Belongs to the DNA photolyase family
D5085_08455	COG1253	flavin adenine dinucleotide binding
D5085_08460	COG4536	flavin adenine dinucleotide binding
D5085_08475	COG2255	four-way junction helicase activity
D5085_08480	COG0824	Thioesterase
D5085_08485	COG0811	peptide transport
D5085_08500	COG0823	Involved in the tonB-independent uptake of proteins
D5085_08515	COG0602	queuosine metabolic process
D5085_08555	COG1388	LysM domain
D5085_08555	COG1470	cell adhesion involved in biofilm formation
D5085_08585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5085_08590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5085_08595	COG2194	sulfuric ester hydrolase activity
D5085_08610	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5085_08635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D5085_08665	COG1987	bacterial-type flagellum assembly
D5085_08670	COG1684	flagellar biosynthetic protein fliR
D5085_08675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5085_08690	COG0455	bacterial-type flagellum organization
D5085_08710	COG0643	Histidine kinase
D5085_08710	COG2198	Histidine kinase
D5085_08715	COG2201	protein-glutamate methylesterase activity
D5085_08720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5085_08730	COG1192	Involved in chromosome partitioning
D5085_08740	COG0835	chemotaxis
D5085_08770	COG3275	phosphorelay sensor kinase activity
D5085_08775	COG1677	Flagellar hook-basal body complex protein FliE
D5085_08785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5085_08805	COG3144	bacterial-type flagellum assembly
D5085_08810	COG0247	lactate metabolic process
D5085_08815	COG4942	peptidase
D5085_08820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5085_08825	COG0640	Transcriptional regulator
D5085_08830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_08845	COG0346	lactoylglutathione lyase activity
D5085_08855	COG0242	peptide deformylase activity
D5085_08885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5085_08895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5085_08900	COG0493	'glutamate synthase
D5085_08905	COG0067	glutamate synthase
D5085_08905	COG0069	glutamate synthase activity
D5085_08905	COG0070	glutamate synthase
D5085_08910	COG0659	secondary active sulfate transmembrane transporter activity
D5085_08945	COG1850	ribulose-bisphosphate carboxylase activity
D5085_08950	COG2204	response regulator
D5085_08955	COG3852	Histidine kinase
D5085_08960	COG3273	potassium ion transport
D5085_08960	COG0471	metal ion transport
D5085_08970	COG0583	DNA-binding transcription factor activity
D5085_09020	COG4451	ribulose bisphosphate carboxylase, small
D5085_09025	COG1850	ribulose-bisphosphate carboxylase activity
D5085_09030	COG0840	transmembrane signaling receptor activity
D5085_09045	COG3122	Protein conserved in bacteria
D5085_09090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5085_09095	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
D5085_09100	COG3259	Nickel-dependent hydrogenase
D5085_09105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5085_09110	COG3264	Mechanosensitive ion channel
D5085_09110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D5085_09130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D5085_09135	COG0450	alkyl hydroperoxide reductase
D5085_09145	COG0840	transmembrane signaling receptor activity
D5085_09160	COG2274	protein secretion by the type I secretion system
D5085_09165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5085_09175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5085_09180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5085_09190	COG0215	cysteine-tRNA ligase activity
D5085_09200	COG0835	chemotaxis
D5085_09200	COG0784	Response regulator, receiver
D5085_09225	COG4660	Part of a membrane complex involved in electron transport
D5085_09235	COG4658	electron transport chain
D5085_09245	COG2878	Part of a membrane complex involved in electron transport
D5085_09250	COG4657	Part of a membrane complex involved in electron transport
D5085_09265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5085_09270	COG1558	bacterial-type flagellum-dependent cell motility
D5085_09275	COG1815	bacterial-type flagellum-dependent cell motility
D5085_09280	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5085_09285	COG4783	chaperone-mediated protein folding
D5085_09290	COG0488	(ABC) transporter
D5085_09315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5085_09325	COG0352	thiamine-phosphate diphosphorylase activity
D5085_09330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5085_09335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5085_09365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5085_09365	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D5085_09380	COG1472	Belongs to the glycosyl hydrolase 3 family
D5085_09400	COG0356	it plays a direct role in the translocation of protons across the membrane
D5085_09410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5085_09415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5085_09420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5085_09425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5085_09430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5085_09435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5085_09440	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5085_09445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5085_09450	COG0459	protein refolding
D5085_09535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5085_09540	COG0795	lipopolysaccharide-transporting ATPase activity
D5085_09545	COG0795	lipopolysaccharide-transporting ATPase activity
D5085_09550	COG2814	Major facilitator Superfamily
D5085_09555	COG1858	cytochrome C peroxidase
D5085_09585	COG0577	efflux transmembrane transporter activity
D5085_09585	COG1136	(ABC) transporter
D5085_09600	COG0084	hydrolase, TatD family'
D5085_09615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5085_09635	COG0419	ATPase involved in DNA repair
D5085_09650	COG3245	cytochrome
D5085_09700	COG1598	PFAM Uncharacterised protein family UPF0150
D5085_09740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_09740	COG0515	serine threonine protein kinase
D5085_09870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5085_09875	COG0163	prenyltransferase activity
D5085_09885	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5085_09895	COG0840	transmembrane signaling receptor activity
D5085_09900	COG2205	protein histidine kinase activity
D5085_09910	COG3706	GGDEF domain
D5085_09920	COG0166	Belongs to the GPI family
D5085_09925	COG0563	adenylate kinase activity
D5085_09930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5085_09935	COG1199	ATP-dependent helicase activity
D5085_09945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5085_09950	COG0328	RNA-DNA hybrid ribonuclease activity
D5085_09955	COG2226	methyltransferase
D5085_09960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5085_09965	COG1388	LysM domain
D5085_09965	COG0741	lytic transglycosylase activity
D5085_09975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5085_09980	COG0667	Aldo Keto reductase
D5085_09995	COG4771	TonB-dependent receptor
D5085_10005	COG0784	Response regulator, receiver
D5085_10005	COG5002	protein histidine kinase activity
D5085_10005	COG2205	protein histidine kinase activity
D5085_10010	COG3706	GGDEF domain
D5085_10010	COG0745	RESPONSE REGULATOR receiver
D5085_10015	COG0728	peptidoglycan biosynthetic process
D5085_10020	COG0494	nUDIX hydrolase
D5085_10025	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D5085_10030	COG0859	PFAM glycosyl transferase family 9
D5085_10035	COG0667	Aldo Keto reductase
D5085_10040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5085_10040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5085_10060	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D5085_10065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5085_10075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5085_10080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D5085_10085	COG0193	aminoacyl-tRNA hydrolase activity
D5085_10090	COG0012	GTP binding
D5085_10095	COG2703	oxygen carrier activity
D5085_10115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_10115	COG0515	serine threonine protein kinase
D5085_10135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_10140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_10145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_10150	COG0649	NAD binding
D5085_10165	COG1034	ATP synthesis coupled electron transport
D5085_10170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5085_10175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_10185	COG0713	ATP synthesis coupled electron transport
D5085_10200	COG1007	ATP synthesis coupled electron transport
D5085_10205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5085_10215	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5085_10220	COG1138	Cytochrome C-type biogenesis protein
D5085_10225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_10240	COG0557	exoribonuclease II activity
D5085_10245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5085_10250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5085_10275	COG0659	secondary active sulfate transmembrane transporter activity
D5085_10280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5085_10370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D5085_10410	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_10420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_10655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_10705	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_10735	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_10745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_10815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_10830	COG1216	Glycosyl transferase, family 2
D5085_10880	COG3657	addiction module killer protein
D5085_10885	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_10920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5085_10945	COG1459	type II secretion system
D5085_11055	COG2244	polysaccharide biosynthetic process
D5085_11175	COG0463	Glycosyl transferase, family 2
D5085_11180	COG3706	GGDEF domain
D5085_11180	COG0745	RESPONSE REGULATOR receiver
D5085_11185	COG2177	Part of the ABC transporter FtsEX involved in
D5085_11190	COG2884	Cell division ATP-binding protein ftsE
D5085_11200	COG0779	Required for maturation of 30S ribosomal subunits
D5085_11205	COG2251	uridine kinase activity
D5085_11205	COG0195	Participates in both transcription termination and antitermination
D5085_11210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5085_11215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5085_11220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5085_11225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5085_11230	COG1185	polyribonucleotide nucleotidyltransferase activity
D5085_11235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5085_11265	COG0859	PFAM glycosyl transferase family 9
D5085_11270	COG3642	lipopolysaccharide core region biosynthetic process
D5085_11275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5085_11285	COG0308	aminopeptidase N
D5085_11315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5085_11320	COG4783	chaperone-mediated protein folding
D5085_11325	COG0268	Binds directly to 16S ribosomal RNA
D5085_11340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D5085_11345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5085_11350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5085_11355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5085_11360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5085_11365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5085_11370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5085_11375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5085_11390	COG0714	Associated with various cellular activities
D5085_11400	COG1194	a g-specific adenine glycosylase
D5085_11405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D5085_11445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D5085_11465	COG0513	Belongs to the DEAD box helicase family
D5085_11470	COG2201	protein-glutamate methylesterase activity
D5085_11475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5085_11480	COG3842	ATPase activity
D5085_11485	COG1178	ABC-type Fe3 transport system permease component
D5085_11490	COG1840	ABC-type Fe3 transport system, periplasmic component
D5085_11500	COG0194	GDP metabolic process
D5085_11510	COG0037	tRNA processing
D5085_11530	COG3072	Adenylate cyclase
D5085_11575	COG1959	2 iron, 2 sulfur cluster binding
D5085_11580	COG1104	cysteine desulfurase activity
D5085_11585	COG1104	cysteine desulfurase activity
D5085_11590	COG0822	iron-sulfur transferase activity
D5085_11595	COG0316	Belongs to the HesB IscA family
D5085_11600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5085_11605	COG0443	Heat shock 70 kDa protein
D5085_11620	COG1596	polysaccharide export
D5085_11620	COG1555	photosystem II stabilization
D5085_11625	COG0254	rRNA binding
D5085_11670	COG0840	transmembrane signaling receptor activity
D5085_11675	COG0643	Histidine kinase
D5085_11675	COG2198	Histidine kinase
D5085_11690	COG0101	tRNA pseudouridine synthase activity
D5085_11695	COG0135	phosphoribosylanthranilate isomerase activity
D5085_11700	COG0133	tryptophan synthase activity
D5085_11705	COG0159	tryptophan synthase activity
D5085_11710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5085_11715	COG0285	dihydrofolate synthase activity
D5085_11725	COG1286	toxin biosynthetic process
D5085_11740	COG3100	YcgL domain-containing protein
D5085_11745	COG0737	Belongs to the 5'-nucleotidase family
D5085_11770	COG0116	Belongs to the methyltransferase superfamily
D5085_11770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5085_11800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5085_11830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D5085_11855	COG0432	Pfam Uncharacterised protein family UPF0047
D5085_11875	COG3278	Belongs to the heme-copper respiratory oxidase family
D5085_11890	COG2010	Cytochrome c
D5085_11905	COG2217	Heavy metal translocating P-type atpase
D5085_11910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5085_11935	COG0835	chemotaxis
D5085_11940	COG2201	protein-glutamate methylesterase activity
D5085_11950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5085_11955	COG0745	RESPONSE REGULATOR receiver
D5085_11960	COG2198	Histidine kinase
D5085_11960	COG0643	Histidine kinase
D5085_11960	COG0643	Histidine kinase
D5085_11960	COG2198	Histidine kinase
D5085_11970	COG1192	Involved in chromosome partitioning
D5085_11975	COG0745	RESPONSE REGULATOR receiver
D5085_11990	COG2172	sigma factor antagonist activity
D5085_11995	COG2172	sigma factor antagonist activity
D5085_12000	COG1366	Belongs to the anti-sigma-factor antagonist family
D5085_12005	COG1366	Belongs to the anti-sigma-factor antagonist family
D5085_12015	COG0745	RESPONSE REGULATOR receiver
D5085_12025	COG0835	chemotaxis
D5085_12030	COG0784	Response regulator, receiver
D5085_12030	COG2205	protein histidine kinase activity
D5085_12030	COG5002	protein histidine kinase activity
D5085_12210	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D5085_12225	COG2176	DNA-directed DNA polymerase activity
D5085_12240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5085_12250	COG2226	methyltransferase
D5085_12295	COG1051	belongs to the nudix hydrolase family
D5085_12305	COG0004	ammonium transporteR
D5085_12310	COG0745	RESPONSE REGULATOR receiver
D5085_12325	COG4565	transcriptional regulatory protein
D5085_12335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5085_12340	COG2853	Lipoprotein
D5085_12350	COG0482	sulfurtransferase activity
D5085_12360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5085_12360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5085_12375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5085_12380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5085_12385	COG0006	proline dipeptidase activity
D5085_12395	COG4968	Prepilin-type N-terminal cleavage methylation domain
D5085_12420	COG1295	ribonuclease BN
D5085_12435	COG0542	response to heat
D5085_12440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5085_12445	COG2814	Major facilitator Superfamily
D5085_12450	COG0793	Belongs to the peptidase S41A family
D5085_12455	COG2861	carbohydrate metabolic process
D5085_12465	COG0181	hydroxymethylbilane synthase activity
D5085_12470	COG1587	Uroporphyrinogen-III synthase
D5085_12555	COG2239	Acts as a magnesium transporter
D5085_12565	COG4786	Flagellar basal body rod
D5085_12570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D5085_12575	COG1706	bacterial-type flagellum-dependent cell motility
D5085_12610	COG0714	Associated with various cellular activities
D5085_12625	COG1573	uracil-dna glycosylase
D5085_12630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5085_12640	COG0505	Belongs to the CarA family
D5085_12650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5085_12655	COG1534	Rna-binding protein
D5085_12660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5085_12665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5085_12670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5085_12680	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5085_12690	COG0411	ABC transporter
D5085_12720	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5085_12735	COG0830	nickel cation binding
D5085_12805	COG0426	domain, Protein
D5085_12845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D5085_12850	COG3177	Filamentation induced by cAMP protein fic
D5085_12855	COG0732	type I restriction modification DNA specificity domain
D5085_12865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D5085_12920	COG0004	ammonium transporteR
D5085_12925	COG0347	Belongs to the P(II) protein family
D5085_12930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5085_12940	COG0360	Binds together with S18 to 16S ribosomal RNA
D5085_12955	COG0359	binds to the 23S rRNA
D5085_12960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5085_12965	COG0305	Participates in initiation and elongation during chromosome replication
D5085_12970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5085_12980	COG2995	paraquat-inducible protein a
D5085_12985	COG3008	intermembrane lipid transfer
D5085_12995	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D5085_13005	COG3072	Adenylate cyclase
D5085_13010	COG2205	protein histidine kinase activity
D5085_13010	COG0784	Response regulator, receiver
D5085_13010	COG5002	protein histidine kinase activity
D5085_13015	COG3437	response regulator, receiver
D5085_13020	COG3437	response regulator, receiver
D5085_13025	COG3850	Histidine kinase
D5085_13025	COG4999	Histidine kinase
D5085_13025	COG3437	response regulator, receiver
D5085_13025	COG2205	protein histidine kinase activity
D5085_13035	COG0589	response to stress
D5085_13045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5085_13065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D5085_13065	COG1918	ferrous iron import across plasma membrane
D5085_13095	COG1115	amino acid carrier protein
D5085_13100	COG2197	response regulator
D5085_13125	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5085_13135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5085_13160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5085_13195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5085_13270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5085_13295	COG2003	Belongs to the UPF0758 family
D5085_13300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5085_13315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5085_13320	COG1234	tRNA 3'-trailer cleavage
D5085_13325	COG0742	ribosomal rna small subunit methyltransferase
D5085_13340	COG2925	Exonuclease
D5085_13365	COG1702	phosphate starvation-inducible protein PhoH
D5085_13370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5085_13375	COG4535	Mg2 and Co2 transporter CorC
D5085_13380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5085_13390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D5085_13400	COG0375	protein maturation
D5085_13405	COG0298	carbon dioxide binding
D5085_13425	COG0210	DNA helicase
D5085_13435	COG2716	regulation of RNA biosynthetic process
D5085_13465	COG4181	ATPase activity
D5085_13470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D5085_13475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_13480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5085_13485	COG0418	dihydroorotase activity
D5085_13495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5085_13535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5085_13545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5085_13550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D5085_13555	COG0205	6-phosphofructokinase activity
D5085_13575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5085_13580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5085_13595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D5085_13600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5085_13605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5085_13615	COG0300	oxidoreductase activity
D5085_13625	COG0784	Response regulator, receiver
D5085_13625	COG0835	chemotaxis
D5085_13635	COG0501	Belongs to the peptidase M48B family
D5085_13735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5085_13750	COG0316	Belongs to the HesB IscA family
D5085_13760	COG1879	ABC-type sugar transport system periplasmic component
D5085_13765	COG0784	Response regulator, receiver
D5085_13765	COG2198	Histidine kinase
D5085_13765	COG5002	protein histidine kinase activity
D5085_13775	COG2197	response regulator
D5085_13780	COG4585	Histidine kinase
D5085_13815	COG0758	DNA mediated transformation
D5085_13820	COG2922	Belongs to the Smg family
D5085_13835	COG1469	GTP cyclohydrolase I activity
D5085_13840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5085_13845	COG0142	geranyltranstransferase activity
D5085_13850	COG1722	exodeoxyribonuclease VII activity
D5085_13860	COG0500	methyltransferase
D5085_13865	COG4106	trans-aconitate 2-methyltransferase activity
D5085_13885	COG1720	tRNA m6t6A37 methyltransferase activity
D5085_13895	COG3706	GGDEF domain
D5085_13905	COG2255	four-way junction helicase activity
D5085_13910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5085_13920	COG5002	protein histidine kinase activity
D5085_13920	COG5001	Diguanylate cyclase
D5085_13925	COG1509	lysine 2,3-aminomutase activity
D5085_13930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5085_13940	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D5085_13955	COG0277	FAD linked oxidase domain protein
D5085_13960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5085_13965	COG0792	nuclease activity
D5085_13970	COG3107	peptidoglycan biosynthetic process
D5085_13980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5085_13985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5085_13990	COG0126	phosphoglycerate kinase activity
D5085_13995	COG0469	pyruvate kinase activity
D5085_14025	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_14025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_14055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5085_14060	COG1758	RNA polymerase activity
D5085_14070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5085_14080	COG0473	3-isopropylmalate dehydrogenase activity
D5085_14090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5085_14090	COG0678	peroxiredoxin activity
D5085_14115	COG3436	PFAM IS66 Orf2 family protein
D5085_14150	COG1132	(ABC) transporter
D5085_14160	COG0811	peptide transport
D5085_14170	COG1570	exodeoxyribonuclease VII activity
D5085_14190	COG0840	transmembrane signaling receptor activity
D5085_14195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5085_14215	COG3864	Putative metallopeptidase domain
D5085_14240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5085_14255	COG2833	Protein of unknown function (DUF455)
D5085_14260	COG3038	cytochrome b561
D5085_14270	COG0617	tRNA 3'-terminal CCA addition
D5085_14275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5085_14280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D5085_14285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5085_14290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D5085_14300	COG0489	protein tyrosine kinase activity
D5085_14305	COG5002	protein histidine kinase activity
D5085_14305	COG5001	Diguanylate cyclase
D5085_14310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5085_14310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5085_14335	COG0495	leucyl-tRNA aminoacylation
D5085_14340	COG0481	GTPase activity
D5085_14360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5085_14375	COG1639	'signal transduction protein
D5085_14380	COG1234	tRNA 3'-trailer cleavage
D5085_14385	COG1968	undecaprenyl-diphosphatase activity
D5085_14400	COG0511	ligase activity, forming carbon-carbon bonds
D5085_14400	COG5016	pyruvate
D5085_14405	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D5085_14410	COG0583	DNA-binding transcription factor activity
D5085_14415	COG0670	Belongs to the BI1 family
D5085_14420	COG0497	DNA recombination
D5085_14440	COG0439	Biotin carboxylase
D5085_14445	COG0511	ligase activity, forming carbon-carbon bonds
D5085_14485	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5085_14490	COG3439	Domain of unknown function DUF302
D5085_14505	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5085_14510	COG0129	dihydroxy-acid dehydratase activity
D5085_14515	COG0784	Response regulator, receiver
D5085_14515	COG3437	response regulator, receiver
D5085_14530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D5085_14535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5085_14540	COG0363	glucosamine-6-phosphate deaminase activity
D5085_14550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5085_14555	COG3106	COG3106 Predicted ATPase
D5085_14560	COG3768	UPF0283 membrane protein
D5085_14570	COG1473	amidohydrolase
D5085_14575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5085_14580	COG0006	proline dipeptidase activity
D5085_14585	COG1012	belongs to the aldehyde dehydrogenase family
D5085_14590	COG1126	abc transporter atp-binding protein
D5085_14605	COG0765	amino acid transport
D5085_14610	COG4597	amino acid ABC transporter
D5085_14615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5085_14620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5085_14630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5085_14640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5085_14645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D5085_14650	COG0631	protein serine/threonine phosphatase activity
D5085_14655	COG4991	sh3 domain protein
D5085_14655	COG3064	Membrane
D5085_14655	COG0515	serine threonine protein kinase
D5085_14660	COG1561	YicC-like family, N-terminal region
D5085_14670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5085_14680	COG2204	response regulator
D5085_14685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D5085_14695	COG0436	Aminotransferase
D5085_14715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5085_14735	COG1660	Displays ATPase and GTPase activities
D5085_14740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D5085_14750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5085_14755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5085_14760	COG1137	ATPase activity
D5085_14775	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5085_14780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D5085_14785	COG0024	Methionine aminopeptidase
D5085_14790	COG0052	Belongs to the universal ribosomal protein uS2 family
D5085_14795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5085_14800	COG0528	UMP kinase activity
D5085_14810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5085_14815	COG0575	Belongs to the CDS family
D5085_14820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5085_14850	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5085_14855	COG1196	nuclear chromosome segregation
D5085_14865	COG0410	ABC transporter
D5085_14880	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5085_14885	COG0842	Transport permease protein
D5085_14890	COG1131	(ABC) transporter
D5085_14905	COG0402	S-adenosylhomocysteine deaminase activity
D5085_14910	COG2850	peptidyl-arginine hydroxylation
D5085_14915	COG0542	response to heat
D5085_14920	COG3437	response regulator, receiver
D5085_14920	COG3850	Histidine kinase
D5085_14920	COG4999	Histidine kinase
D5085_14920	COG2205	protein histidine kinase activity
D5085_14925	COG1879	ABC-type sugar transport system periplasmic component
D5085_14935	COG0784	Response regulator, receiver
D5085_14935	COG5002	protein histidine kinase activity
D5085_14955	COG3437	response regulator, receiver
D5085_14970	COG0724	RNA recognition motif
D5085_15000	COG2274	protein secretion by the type I secretion system
D5085_15015	COG0776	regulation of translation
D5085_15035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5085_15045	COG3437	response regulator, receiver
D5085_15045	COG2770	Histidine kinase
D5085_15050	COG4191	Histidine kinase
D5085_15060	COG0527	aspartate kinase activity
D5085_15065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5085_15075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5085_15100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5085_15125	COG2119	membrane
D5085_15155	COG0840	transmembrane signaling receptor activity
D5085_15160	COG0835	chemotaxis
D5085_15170	COG0643	Histidine kinase
D5085_15170	COG2198	Histidine kinase
D5085_15180	COG0745	RESPONSE REGULATOR receiver
D5085_15185	COG0840	transmembrane signaling receptor activity
D5085_15210	COG0735	belongs to the Fur family
D5085_15225	COG0733	neurotransmitter:sodium symporter activity
D5085_15235	COG0330	HflC and HflK could
D5085_15240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5085_15285	COG1459	type II secretion system
D5085_15300	COG3031	protein transport across the cell outer membrane
D5085_15305	COG0343	queuine tRNA-ribosyltransferase activity
D5085_15315	COG0835	chemotaxis
D5085_15335	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
D5085_15435	COG5001	Diguanylate cyclase
D5085_15445	COG3437	response regulator, receiver
D5085_15445	COG0784	Response regulator, receiver
D5085_15450	COG4191	Histidine kinase
D5085_15485	COG3437	response regulator, receiver
D5085_15485	COG0784	Response regulator, receiver
D5085_15530	COG0784	Response regulator, receiver
D5085_15530	COG5002	protein histidine kinase activity
D5085_15530	COG2198	Histidine kinase
D5085_15535	COG3437	response regulator, receiver
D5085_15540	COG0784	Response regulator, receiver
D5085_15540	COG2198	Histidine kinase
D5085_15540	COG5002	protein histidine kinase activity
D5085_15570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5085_15575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5085_15605	COG0840	transmembrane signaling receptor activity
D5085_15625	COG0724	RNA recognition motif
D5085_15630	COG2915	High frequency lysogenization protein hflD homolog
D5085_15635	COG0837	glucose binding
D5085_15640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5085_15650	COG1640	4-alpha-glucanotransferase
D5085_15655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D5085_15660	COG0297	glycogen (starch) synthase activity
D5085_15665	COG0058	SHG alpha-glucan phosphorylase activity
D5085_15670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5085_15680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D5085_15690	COG0151	Belongs to the GarS family
D5085_15705	COG0742	ribosomal rna small subunit methyltransferase
D5085_15710	COG0612	Peptidase, M16
D5085_15715	COG0612	Peptidase, M16
D5085_15720	COG0552	protein localization to endoplasmic reticulum
D5085_15735	COG2200	EAL domain
D5085_15760	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5085_15825	COG0745	RESPONSE REGULATOR receiver
D5085_15885	COG3436	PFAM IS66 Orf2 family protein
D5085_15895	COG2204	response regulator
D5085_15905	COG5002	protein histidine kinase activity
D5085_15910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5085_15915	COG1518	maintenance of DNA repeat elements
D5085_15930	COG1857	crispr-associated protein
D5085_15995	COG5001	Diguanylate cyclase
D5085_15995	COG3300	MHYT domain
D5085_16015	COG2350	Protein conserved in bacteria
D5085_16025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5085_16040	COG0527	aspartate kinase activity
D5085_16050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5085_16055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5085_16060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5085_16070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5085_16115	COG2914	Belongs to the UPF0125 (RnfH) family
D5085_16125	COG4659	FMN binding
D5085_16130	COG4658	electron transport chain
D5085_16140	COG2878	Part of a membrane complex involved in electron transport
D5085_16145	COG4657	Part of a membrane complex involved in electron transport
D5085_16210	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5085_16215	COG0326	Molecular chaperone. Has ATPase activity
D5085_16220	COG0033	Phosphoglucomutase
D5085_16250	COG0784	Response regulator, receiver
D5085_16250	COG5002	protein histidine kinase activity
D5085_16250	COG2205	protein histidine kinase activity
D5085_16255	COG5002	protein histidine kinase activity
D5085_16255	COG2205	protein histidine kinase activity
D5085_16255	COG0784	Response regulator, receiver
D5085_16265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5085_16270	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D5085_16280	COG0850	regulation of cytokinetic process
D5085_16290	COG2022	thiamine diphosphate biosynthetic process
D5085_16295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5085_16315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_16320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5085_16325	COG4536	flavin adenine dinucleotide binding
D5085_16345	COG2308	Evidence 4 Homologs of previously reported genes of
D5085_16405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5085_16410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5085_16425	COG0776	regulation of translation
D5085_16430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5085_16435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5085_16440	COG0740	serine-type endopeptidase activity
D5085_16445	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5085_16460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5085_16475	COG0540	Belongs to the ATCase OTCase family
D5085_16480	COG1183	phosphatidylcholine synthase activity
D5085_16495	COG0165	Argininosuccinate lyase
D5085_16500	COG2945	thiolester hydrolase activity
D5085_16510	COG2197	response regulator
D5085_16515	COG0563	adenylate kinase activity
D5085_16520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_16525	COG0625	glutathione transferase activity
D5085_16530	COG0717	Belongs to the dCTP deaminase family
D5085_16535	COG3066	DNA modification
D5085_16580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5085_16585	COG0784	Response regulator, receiver
D5085_16585	COG5002	protein histidine kinase activity
D5085_16585	COG2205	protein histidine kinase activity
D5085_16610	COG5002	protein histidine kinase activity
D5085_16610	COG2205	protein histidine kinase activity
D5085_16610	COG0784	Response regulator, receiver
D5085_16615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D5085_16620	COG0720	synthase
D5085_16630	COG2239	Acts as a magnesium transporter
D5085_16635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5085_16640	COG0022	dehydrogenase e1 component
D5085_16640	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5085_16645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5085_16650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5085_16655	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5085_16665	COG0330	HflC and HflK could
D5085_16670	COG0330	HflC and HflK could
D5085_16680	COG0436	Aminotransferase
D5085_16685	COG2171	N-acyltransferase activity
D5085_16690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5085_16695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D5085_16710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5085_16730	COG1196	nuclear chromosome segregation
D5085_16740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_16770	COG1965	Belongs to the frataxin family
D5085_16785	COG2274	protein secretion by the type I secretion system
D5085_16805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5085_16810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5085_16820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5085_16825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5085_16855	COG0649	NAD binding
D5085_16860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_16860	COG0649	NAD binding
D5085_16865	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_16875	COG0651	ATP synthesis coupled electron transport
D5085_16880	COG1006	Multisubunit Na H antiporter MnhC subunit
D5085_16885	COG2111	Na H antiporter
D5085_16900	COG2212	antiporter activity
D5085_16925	COG3005	denitrification pathway
D5085_16930	COG2863	cytochrome
D5085_16935	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5085_16940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5085_16950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5085_17000	COG5265	(ABC) transporter
D5085_17015	COG1562	ergosterol biosynthetic process
D5085_17020	COG1562	ergosterol biosynthetic process
D5085_17025	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D5085_17030	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_17035	COG3706	GGDEF domain
D5085_17040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D5085_17050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5085_17055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5085_17060	COG0287	Prephenate dehydrogenase
D5085_17065	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5085_17070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5085_17075	COG1605	Chorismate mutase
D5085_17075	COG0077	Prephenate dehydratase
D5085_17080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5085_17085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5085_17095	COG2969	positive regulation of protein catabolic process
D5085_17100	COG0625	glutathione transferase activity
D5085_17105	COG2857	Cytochrome c1
D5085_17110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5085_17115	COG0723	plastoquinol--plastocyanin reductase activity
D5085_17120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5085_17140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5085_17140	COG0574	Belongs to the PEP-utilizing enzyme family
D5085_17150	COG0457	Tetratricopeptide repeat
D5085_17150	COG0859	PFAM glycosyl transferase family 9
D5085_17170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D5085_17200	COG1943	Transposase
D5085_17215	COG0756	dUTP diphosphatase activity
D5085_17220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5085_17230	COG2205	protein histidine kinase activity
D5085_17230	COG2202	Pas domain
D5085_17235	COG0745	RESPONSE REGULATOR receiver
D5085_17235	COG3706	GGDEF domain
D5085_17250	COG1444	tRNA N-acetyltransferase activity
D5085_17270	COG4206	TonB-dependent receptor
D5085_17275	COG0009	L-threonylcarbamoyladenylate synthase
D5085_17280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5085_17290	COG3437	response regulator, receiver
D5085_17295	COG0438	transferase activity, transferring glycosyl groups
D5085_17310	COG0745	RESPONSE REGULATOR receiver
D5085_17315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5085_17315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5085_17320	COG5002	protein histidine kinase activity
D5085_17320	COG2205	protein histidine kinase activity
D5085_17320	COG0784	Response regulator, receiver
D5085_17335	COG2217	Heavy metal translocating P-type atpase
D5085_17350	COG1960	acyl-CoA dehydrogenase activity
D5085_17360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5085_17375	COG0003	Pfam Anion-transporting ATPase
D5085_17390	COG1047	Peptidyl-prolyl cis-trans
D5085_17415	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D5085_17425	COG3657	addiction module killer protein
D5085_17430	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_17440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5085_17470	COG2197	response regulator
D5085_17480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5085_17545	COG0247	lactate metabolic process
D5085_17555	COG1530	ribonuclease E activity
D5085_17560	COG0424	maF-like protein
D5085_17565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5085_17575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5085_17585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5085_17615	COG0372	Belongs to the citrate synthase family
D5085_17625	COG2133	pyrroloquinoline quinone binding
D5085_17635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5085_17640	COG1846	Transcriptional regulator
D5085_17650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5085_17655	COG1917	Cupin 2, conserved barrel domain protein
D5085_17670	COG1011	Hydrolase
D5085_17675	COG1218	3'(2'),5'-bisphosphate nucleotidase
D5085_17680	COG0367	asparagine synthase
D5085_17695	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5085_17700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5085_17710	COG4133	protoheme IX ABC transporter activity
D5085_17720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5085_17745	COG1090	epimerase
D5085_17800	COG3156	type II secretion system protein K
D5085_17815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5085_17840	COG1671	Belongs to the UPF0178 family
D5085_17845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5085_17850	COG0840	transmembrane signaling receptor activity
D5085_17865	COG0745	RESPONSE REGULATOR receiver
D5085_17880	COG2770	Histidine kinase
D5085_17880	COG2208	phosphoserine phosphatase activity
D5085_17895	COG1238	metal cluster binding
D5085_17900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5085_17905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5085_17920	COG1459	type II secretion system
D5085_17930	COG0167	dihydroorotate dehydrogenase activity
D5085_17935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5085_17945	COG2212	antiporter activity
D5085_17955	COG0651	ATP synthesis coupled electron transport
D5085_17960	COG1006	Multisubunit Na H antiporter MnhC subunit
D5085_17965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5085_17965	COG2111	Na H antiporter
D5085_17970	COG0366	Alpha amylase catalytic
D5085_17975	COG1215	transferase activity, transferring glycosyl groups
D5085_18020	COG0281	malic enzyme
D5085_18025	COG0196	riboflavin kinase activity
D5085_18030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5085_18040	COG0514	ATP-dependent DNA helicase (RecQ)
D5085_18085	COG4942	peptidase
D5085_18105	COG0745	RESPONSE REGULATOR receiver
D5085_18115	COG0704	Plays a role in the regulation of phosphate uptake
D5085_18120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5085_18125	COG0581	inorganic phosphate transmembrane transporter activity
D5085_18130	COG0573	inorganic phosphate transmembrane transporter activity
D5085_18135	COG1653	transport
D5085_18145	COG5001	Diguanylate cyclase
D5085_18145	COG2203	Gaf domain
D5085_18145	COG3706	GGDEF domain
D5085_18145	COG4251	negative regulation of phosphorylation
D5085_18165	COG0516	GMP reductase activity
D5085_18165	COG0517	IMP dehydrogenase activity
D5085_18185	COG0436	Aminotransferase
D5085_18190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5085_18200	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_18200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_18205	COG2183	response to ionizing radiation
D5085_18215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5085_18220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5085_18240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5085_18245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5085_18250	COG2205	protein histidine kinase activity
D5085_18250	COG5002	protein histidine kinase activity
D5085_18250	COG0784	Response regulator, receiver
D5085_18255	COG0784	Response regulator, receiver
D5085_18255	COG5002	protein histidine kinase activity
D5085_18255	COG2205	protein histidine kinase activity
D5085_18260	COG2048	Heterodisulfide reductase, subunit B
D5085_18265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5085_18275	COG1233	COG1233 Phytoene dehydrogenase and related
D5085_18280	COG0142	geranyltranstransferase activity
D5085_18315	COG0174	glutamine synthetase
D5085_18320	COG3852	Histidine kinase
D5085_18350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5085_18365	COG0189	ligase activity
D5085_18465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5085_18465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D5085_18470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5085_18475	COG0148	phosphopyruvate hydratase activity
D5085_18480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5085_18485	COG0504	CTP synthase activity
D5085_18490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D5085_18495	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5085_18510	COG0137	argininosuccinate synthase activity
D5085_18515	COG5002	protein histidine kinase activity
D5085_18515	COG5001	Diguanylate cyclase
D5085_18520	COG1765	OsmC-like protein
D5085_18525	COG0519	Catalyzes the synthesis of GMP from XMP
D5085_18525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5085_18530	COG0590	tRNA wobble adenosine to inosine editing
D5085_18560	COG0189	ligase activity
D5085_18565	COG0189	ligase activity
D5085_18565	COG4067	protein conserved in archaea
D5085_18570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5085_18575	COG0494	nUDIX hydrolase
D5085_18580	COG3022	response to hydroperoxide
D5085_18595	COG2197	response regulator
D5085_18620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5085_18635	COG0776	regulation of translation
D5085_18640	COG0072	phenylalanine-tRNA ligase activity
D5085_18645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5085_18650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5085_18655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D5085_18660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5085_18665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5085_18685	COG3118	belongs to the thioredoxin family
D5085_18695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5085_18700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D5085_18710	COG0019	diaminopimelate decarboxylase activity
D5085_18715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D5085_18725	COG0529	Catalyzes the synthesis of activated sulfate
D5085_18735	COG0516	GMP reductase activity
D5085_18735	COG0517	IMP dehydrogenase activity
D5085_18745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family