locus-tag	class	description
HDN1F_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HDN1F_00020	COG0592	DNA-directed DNA polymerase activity
HDN1F_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HDN1F_00110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HDN1F_00120	COG1984	allophanate hydrolase subunit 2
HDN1F_00130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HDN1F_00160	COG0702	epimerase
HDN1F_00170	COG0671	phosphoesterase, PA-phosphatase related
HDN1F_00190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HDN1F_00210	COG0300	oxidoreductase activity
HDN1F_00270	COG0789	Transcriptional regulator
HDN1F_00280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HDN1F_00320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HDN1F_00390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HDN1F_00420	COG5002	protein histidine kinase activity
HDN1F_00490	COG0758	DNA mediated transformation
HDN1F_00500	COG4191	Histidine kinase
HDN1F_00580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HDN1F_00590	COG0408	coproporphyrinogen oxidase activity
HDN1F_00600	COG0009	L-threonylcarbamoyladenylate synthase
HDN1F_00610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HDN1F_00630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HDN1F_00650	COG0628	permease
HDN1F_00660	COG0517	IMP dehydrogenase activity
HDN1F_00800	COG2205	protein histidine kinase activity
HDN1F_00800	COG2198	Histidine kinase
HDN1F_00800	COG0784	Response regulator, receiver
HDN1F_00800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HDN1F_00810	COG5001	Diguanylate cyclase
HDN1F_00810	COG5002	protein histidine kinase activity
HDN1F_00840	COG3437	response regulator, receiver
HDN1F_00840	COG2205	protein histidine kinase activity
HDN1F_00840	COG4999	Histidine kinase
HDN1F_00840	COG3850	Histidine kinase
HDN1F_00880	COG5002	protein histidine kinase activity
HDN1F_00880	COG0784	Response regulator, receiver
HDN1F_00880	COG2205	protein histidine kinase activity
HDN1F_00920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HDN1F_00930	COG0019	diaminopimelate decarboxylase activity
HDN1F_00940	COG3072	Adenylate cyclase
HDN1F_00950	COG2200	EAL domain
HDN1F_00950	COG2202	Pas domain
HDN1F_00950	COG2199	diguanylate cyclase activity
HDN1F_00960	COG0165	Argininosuccinate lyase
HDN1F_00970	COG3275	phosphorelay sensor kinase activity
HDN1F_00980	COG3246	L-lysine catabolic process to acetate
HDN1F_01060	COG0248	Ppx GppA phosphatase
HDN1F_01070	COG3119	arylsulfatase activity
HDN1F_01140	COG0438	transferase activity, transferring glycosyl groups
HDN1F_01140	COG1216	Glycosyl transferase, family 2
HDN1F_01180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HDN1F_01190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HDN1F_01200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HDN1F_01230	COG3079	Belongs to the UPF0149 family
HDN1F_01240	COG0006	proline dipeptidase activity
HDN1F_01260	COG0509	glycine decarboxylation via glycine cleavage system
HDN1F_01270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HDN1F_01280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HDN1F_01310	COG2183	response to ionizing radiation
HDN1F_01320	COG0745	RESPONSE REGULATOR receiver
HDN1F_01360	COG0494	nUDIX hydrolase
HDN1F_01390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HDN1F_01400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HDN1F_01430	COG1196	nuclear chromosome segregation
HDN1F_01430	COG3264	Mechanosensitive ion channel
HDN1F_01440	COG2900	Belongs to the SlyX family
HDN1F_01510	COG0129	dihydroxy-acid dehydratase activity
HDN1F_01550	COG0583	DNA-binding transcription factor activity
HDN1F_01580	COG2205	protein histidine kinase activity
HDN1F_01580	COG0784	Response regulator, receiver
HDN1F_01590	COG3437	response regulator, receiver
HDN1F_01630	COG1253	flavin adenine dinucleotide binding
HDN1F_01650	COG2030	dehydratase
HDN1F_01690	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_01700	COG0840	transmembrane signaling receptor activity
HDN1F_01710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HDN1F_01720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HDN1F_01740	COG2813	Specifically methylates the guanine in position
HDN1F_01740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HDN1F_01750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HDN1F_01790	COG2198	Histidine kinase
HDN1F_01790	COG0643	Histidine kinase
HDN1F_01800	COG0835	chemotaxis
HDN1F_01810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HDN1F_01840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HDN1F_01850	COG1121	(ABC) transporter
HDN1F_01870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HDN1F_01920	COG0729	surface antigen
HDN1F_02020	COG0076	glutamate decarboxylase activity
HDN1F_02110	COG2814	Major facilitator Superfamily
HDN1F_02130	COG0606	chelatase, subunit chli
HDN1F_02140	COG0604	alcohol dehydrogenase
HDN1F_02170	COG0500	methyltransferase
HDN1F_02180	COG3268	Saccharopine dehydrogenase
HDN1F_02240	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_02250	COG0210	DNA helicase
HDN1F_02260	COG3245	cytochrome
HDN1F_02290	COG0215	cysteine-tRNA ligase activity
HDN1F_02300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HDN1F_02390	COG3848	Pyruvate phosphate dikinase
HDN1F_02390	COG0574	Belongs to the PEP-utilizing enzyme family
HDN1F_02410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HDN1F_02460	COG2824	Alkylphosphonate utilization operon protein PhnA
HDN1F_02510	COG0183	Belongs to the thiolase family
HDN1F_02540	COG0446	pyridine nucleotide-disulphide oxidoreductase
HDN1F_02540	COG1902	pentaerythritol trinitrate reductase activity
HDN1F_02570	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_02580	COG1053	succinate dehydrogenase
HDN1F_02590	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_02690	COG3459	Glycosyltransferase 36 associated
HDN1F_02700	COG4178	(ABC) transporter
HDN1F_02710	COG4399	Belongs to the UPF0754 family
HDN1F_02740	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_02770	COG2081	HI0933 family
HDN1F_02850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HDN1F_02860	COG1758	RNA polymerase activity
HDN1F_02900	COG2223	nitrite transmembrane transporter activity
HDN1F_02910	COG2239	Acts as a magnesium transporter
HDN1F_02920	COG0625	glutathione transferase activity
HDN1F_02930	COG0121	glutamine amidotransferase
HDN1F_02940	COG2205	protein histidine kinase activity
HDN1F_02940	COG0784	Response regulator, receiver
HDN1F_02980	COG1960	acyl-CoA dehydrogenase activity
HDN1F_02990	COG1960	acyl-CoA dehydrogenase activity
HDN1F_03000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HDN1F_03010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_03030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HDN1F_03050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HDN1F_03060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_03070	COG0586	Pfam SNARE associated Golgi protein
HDN1F_03090	COG0352	thiamine-phosphate diphosphorylase activity
HDN1F_03100	COG0352	thiamine-phosphate diphosphorylase activity
HDN1F_03100	COG0351	phosphomethylpyrimidine kinase
HDN1F_03170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HDN1F_03180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HDN1F_03200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HDN1F_03210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HDN1F_03220	COG0268	Binds directly to 16S ribosomal RNA
HDN1F_03230	COG0196	riboflavin kinase activity
HDN1F_03240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HDN1F_03250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HDN1F_03260	COG1047	Peptidyl-prolyl cis-trans
HDN1F_03270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HDN1F_03420	COG0542	response to heat
HDN1F_03450	COG0028	Belongs to the TPP enzyme family
HDN1F_03470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HDN1F_03480	COG1183	phosphatidylcholine synthase activity
HDN1F_03540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HDN1F_03550	COG0081	regulation of translation
HDN1F_03560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HDN1F_03570	COG0222	ribosome binding
HDN1F_03580	COG0085	RNA polymerase activity
HDN1F_03600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HDN1F_03610	COG0049	tRNA binding
HDN1F_03620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HDN1F_03640	COG0051	transcription antitermination factor activity, RNA binding
HDN1F_03650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HDN1F_03660	COG0088	Forms part of the polypeptide exit tunnel
HDN1F_03670	COG0089	rRNA binding
HDN1F_03680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HDN1F_03690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HDN1F_03700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HDN1F_03710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HDN1F_03720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HDN1F_03730	COG0255	Belongs to the universal ribosomal protein uL29 family
HDN1F_03750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HDN1F_03760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HDN1F_03770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HDN1F_03780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HDN1F_03800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HDN1F_03810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HDN1F_03820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HDN1F_03830	COG1841	ribosomal large subunit assembly
HDN1F_03840	COG0200	Binds to the 23S rRNA
HDN1F_03870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HDN1F_03880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HDN1F_03890	COG0202	RNA polymerase activity
HDN1F_03900	COG0203	ribosomal protein L17
HDN1F_04000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HDN1F_04020	COG0514	ATP-dependent DNA helicase (RecQ)
HDN1F_04040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HDN1F_04080	COG1040	competence protein
HDN1F_04090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HDN1F_04100	COG0156	8-amino-7-oxononanoate synthase activity
HDN1F_04110	COG0596	Alpha beta hydrolase
HDN1F_04130	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HDN1F_04140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HDN1F_04150	COG0277	FAD linked oxidase domain protein
HDN1F_04160	COG0179	Fumarylacetoacetate (FAA) hydrolase
HDN1F_04180	COG2207	Transcriptional regulator
HDN1F_04190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_04240	COG4191	Histidine kinase
HDN1F_04270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HDN1F_04300	COG0330	HflC and HflK could
HDN1F_04340	COG1234	tRNA 3'-trailer cleavage
HDN1F_04370	COG3706	GGDEF domain
HDN1F_04370	COG4251	negative regulation of phosphorylation
HDN1F_04370	COG2203	Gaf domain
HDN1F_04370	COG5001	Diguanylate cyclase
HDN1F_04380	COG0321	lipoyl(octanoyl) transferase activity
HDN1F_04400	COG1686	Belongs to the peptidase S11 family
HDN1F_04420	COG2951	lytic endotransglycosylase activity
HDN1F_04430	COG0772	Belongs to the SEDS family
HDN1F_04440	COG0768	penicillin binding
HDN1F_04450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HDN1F_04470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HDN1F_04480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HDN1F_04600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HDN1F_04670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HDN1F_04680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HDN1F_04700	COG2124	cytochrome p450
HDN1F_04700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HDN1F_04720	COG0243	molybdopterin cofactor binding
HDN1F_04730	COG1454	alcohol dehydrogenase
HDN1F_04750	COG0840	transmembrane signaling receptor activity
HDN1F_04760	COG2832	Protein of unknown function (DUF454)
HDN1F_05100	COG1136	(ABC) transporter
HDN1F_05120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HDN1F_05150	COG1561	YicC-like family, N-terminal region
HDN1F_05160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HDN1F_05170	COG0708	Exodeoxyribonuclease III
HDN1F_05200	COG1309	transcriptional regulator
HDN1F_05210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HDN1F_05240	COG2003	Belongs to the UPF0758 family
HDN1F_05250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HDN1F_05260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HDN1F_05270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HDN1F_05320	COG0494	nUDIX hydrolase
HDN1F_05360	COG2146	nitrite reductase [NAD(P)H] activity
HDN1F_05360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HDN1F_05370	COG2146	nitrite reductase [NAD(P)H] activity
HDN1F_05370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HDN1F_05380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HDN1F_05390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HDN1F_05420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HDN1F_05430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HDN1F_05510	COG1181	Belongs to the D-alanine--D-alanine ligase family
HDN1F_05520	COG0726	polysaccharide deacetylase
HDN1F_05590	COG2755	lipolytic protein G-D-S-L family
HDN1F_05590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HDN1F_05600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HDN1F_05610	COG1132	(ABC) transporter
HDN1F_05630	COG1216	Glycosyl transferase, family 2
HDN1F_05640	COG3108	Peptidase M15
HDN1F_05650	COG2989	Protein conserved in bacteria
HDN1F_05680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HDN1F_05730	COG0420	3'-5' exonuclease activity
HDN1F_05740	COG0500	methyltransferase
HDN1F_05770	COG3038	cytochrome b561
HDN1F_05780	COG2353	YceI-like domain
HDN1F_05790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HDN1F_05800	COG0643	Histidine kinase
HDN1F_05800	COG2198	Histidine kinase
HDN1F_05820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HDN1F_05830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HDN1F_05840	COG2009	succinate dehydrogenase
HDN1F_05850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HDN1F_05860	COG1053	succinate dehydrogenase
HDN1F_05870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HDN1F_05890	COG2076	Multidrug Resistance protein
HDN1F_05910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HDN1F_06050	COG0463	Glycosyl transferase, family 2
HDN1F_06050	COG1216	Glycosyl transferase, family 2
HDN1F_06080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HDN1F_06090	COG0438	transferase activity, transferring glycosyl groups
HDN1F_06120	COG4372	Transposase
HDN1F_06130	COG3436	PFAM IS66 Orf2 family protein
HDN1F_06150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HDN1F_06160	COG0154	amidase activity
HDN1F_06170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HDN1F_06180	COG1077	Cell shape determining protein MreB Mrl
HDN1F_06190	COG1792	Involved in formation and maintenance of cell shape
HDN1F_06200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HDN1F_06210	COG0424	maF-like protein
HDN1F_06220	COG1530	ribonuclease E activity
HDN1F_06240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HDN1F_06250	COG3028	Belongs to the UPF0307 family
HDN1F_06280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HDN1F_06290	COG1660	Displays ATPase and GTPase activities
HDN1F_06310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HDN1F_06320	COG1137	ATPase activity
HDN1F_06330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HDN1F_06360	COG1127	ABC transporter
HDN1F_06370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HDN1F_06380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HDN1F_06400	COG0271	Belongs to the BolA IbaG family
HDN1F_06410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HDN1F_06420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HDN1F_06430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HDN1F_06440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HDN1F_06470	COG2046	Belongs to the sulfate adenylyltransferase family
HDN1F_06480	COG0071	Belongs to the small heat shock protein (HSP20) family
HDN1F_06500	COG2945	thiolester hydrolase activity
HDN1F_06510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HDN1F_06520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HDN1F_06530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HDN1F_06540	COG0723	plastoquinol--plastocyanin reductase activity
HDN1F_06550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HDN1F_06560	COG2857	Cytochrome c1
HDN1F_06570	COG2969	positive regulation of protein catabolic process
HDN1F_06580	COG2823	Periplasmic or secreted lipoprotein
HDN1F_06590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HDN1F_06610	COG0792	nuclease activity
HDN1F_06620	COG3107	peptidoglycan biosynthetic process
HDN1F_06630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HDN1F_06650	COG0275	rRNA processing
HDN1F_06660	COG3116	cell division
HDN1F_06680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HDN1F_06690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HDN1F_06700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HDN1F_06710	COG0772	Belongs to the SEDS family
HDN1F_06720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HDN1F_06730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HDN1F_06770	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HDN1F_06790	COG0653	protein targeting
HDN1F_06800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HDN1F_06810	COG0494	nUDIX hydrolase
HDN1F_06880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HDN1F_06900	COG0488	(ABC) transporter
HDN1F_06920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HDN1F_06940	COG0438	transferase activity, transferring glycosyl groups
HDN1F_07010	COG4633	Protein conserved in bacteria
HDN1F_07040	COG2119	membrane
HDN1F_07050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HDN1F_07060	COG1205	dead DEAH box helicase
HDN1F_07060	COG1111	helicase
HDN1F_07070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HDN1F_07100	COG3177	Filamentation induced by cAMP protein fic
HDN1F_07180	COG0582	viral genome integration into host DNA
HDN1F_07210	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HDN1F_07220	COG1194	a g-specific adenine glycosylase
HDN1F_07240	COG0131	Imidazoleglycerol-phosphate dehydratase
HDN1F_07260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HDN1F_07270	COG0107	imidazoleglycerol-phosphate synthase activity
HDN1F_07280	COG0793	Belongs to the peptidase S41A family
HDN1F_07290	COG4942	peptidase
HDN1F_07310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HDN1F_07330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HDN1F_07340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HDN1F_07380	COG0425	Belongs to the sulfur carrier protein TusA family
HDN1F_07380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HDN1F_07430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HDN1F_07440	COG0732	type I restriction modification DNA specificity domain
HDN1F_07450	COG4804	nuclease activity
HDN1F_07460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HDN1F_07510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HDN1F_07520	COG0439	Biotin carboxylase
HDN1F_07540	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_07560	COG4109	DRTGG domain
HDN1F_07580	COG1203	CRISPR-associated helicase, Cas3
HDN1F_07610	COG1857	crispr-associated protein
HDN1F_07650	COG1518	maintenance of DNA repeat elements
HDN1F_07660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HDN1F_07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
HDN1F_07730	COG4589	Belongs to the CDS family
HDN1F_07790	COG2203	Gaf domain
HDN1F_07790	COG3706	GGDEF domain
HDN1F_07790	COG5001	Diguanylate cyclase
HDN1F_07790	COG4251	negative regulation of phosphorylation
HDN1F_07830	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HDN1F_07840	COG1704	LemA family
HDN1F_07870	COG0750	zinc metalloprotease
HDN1F_07910	COG0840	transmembrane signaling receptor activity
HDN1F_07920	COG1858	cytochrome C peroxidase
HDN1F_07950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HDN1F_08010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HDN1F_08020	COG3101	peptidyl-lysine hydroxylation
HDN1F_08030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HDN1F_08040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HDN1F_08070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HDN1F_08080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HDN1F_08080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HDN1F_08130	COG1960	acyl-CoA dehydrogenase activity
HDN1F_08200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HDN1F_08220	COG2096	Adenosyltransferase
HDN1F_08230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HDN1F_08240	COG0745	RESPONSE REGULATOR receiver
HDN1F_08260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HDN1F_08300	COG1024	Enoyl-CoA hydratase
HDN1F_08340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HDN1F_08370	COG4804	nuclease activity
HDN1F_08400	COG4804	nuclease activity
HDN1F_08430	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HDN1F_08460	COG0513	Belongs to the DEAD box helicase family
HDN1F_08480	COG0154	amidase activity
HDN1F_08500	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HDN1F_08520	COG0500	methyltransferase
HDN1F_08540	COG0560	Phosphoserine phosphatase
HDN1F_08540	COG3830	Belongs to the UPF0237 family
HDN1F_08580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HDN1F_08590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HDN1F_08600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HDN1F_08610	COG0149	triose-phosphate isomerase activity
HDN1F_08620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HDN1F_08630	COG0779	Required for maturation of 30S ribosomal subunits
HDN1F_08640	COG0195	Participates in both transcription termination and antitermination
HDN1F_08650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HDN1F_08660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HDN1F_08670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HDN1F_08680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HDN1F_08690	COG1185	polyribonucleotide nucleotidyltransferase activity
HDN1F_08720	COG1466	dna polymerase III delta subunit
HDN1F_08740	COG0495	leucyl-tRNA aminoacylation
HDN1F_08750	COG0546	phosphoglycolate phosphatase activity
HDN1F_08760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HDN1F_08770	COG4535	Mg2 and Co2 transporter CorC
HDN1F_08780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HDN1F_08790	COG1702	phosphate starvation-inducible protein PhoH
HDN1F_08850	COG0316	Belongs to the HesB IscA family
HDN1F_08860	COG0739	heme binding
HDN1F_08870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HDN1F_08880	COG1560	Kdo2-lipid A biosynthetic process
HDN1F_08900	COG0354	folic acid binding
HDN1F_08960	COG2272	Belongs to the type-B carboxylesterase lipase family
HDN1F_08970	COG0501	Belongs to the peptidase M48B family
HDN1F_09000	COG0183	Belongs to the thiolase family
HDN1F_09060	COG3383	formate dehydrogenase (NAD+) activity
HDN1F_09110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HDN1F_09150	COG5001	Diguanylate cyclase
HDN1F_09150	COG5002	protein histidine kinase activity
HDN1F_09170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HDN1F_09190	COG0456	acetyltransferase
HDN1F_09200	COG0438	transferase activity, transferring glycosyl groups
HDN1F_09210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HDN1F_09230	COG1090	epimerase
HDN1F_09280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HDN1F_09290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HDN1F_09340	COG0481	GTPase activity
HDN1F_09370	COG0571	ribonuclease III activity
HDN1F_09380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HDN1F_09390	COG1381	Involved in DNA repair and RecF pathway recombination
HDN1F_09410	COG0736	holo-[acyl-carrier-protein] synthase activity
HDN1F_09420	COG5002	protein histidine kinase activity
HDN1F_09420	COG2205	protein histidine kinase activity
HDN1F_09420	COG0784	Response regulator, receiver
HDN1F_09460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HDN1F_09470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HDN1F_09480	COG0521	Mo-molybdopterin cofactor biosynthetic process
HDN1F_09520	COG2264	protein methyltransferase activity
HDN1F_09550	COG0674	pyruvate-flavodoxin oxidoreductase activity
HDN1F_09550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HDN1F_09570	COG0697	spore germination
HDN1F_09580	COG3047	cAMP biosynthetic process
HDN1F_09610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_09620	COG0494	nUDIX hydrolase
HDN1F_09630	COG3151	Protein conserved in bacteria
HDN1F_09640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HDN1F_09650	COG0133	tryptophan synthase activity
HDN1F_09660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HDN1F_09680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HDN1F_09690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HDN1F_09720	COG1546	Belongs to the CinA family
HDN1F_09760	COG4149	molybdate abc transporter
HDN1F_09770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HDN1F_09780	COG4771	TonB-dependent receptor
HDN1F_09800	COG1309	transcriptional regulator
HDN1F_09810	COG0300	oxidoreductase activity
HDN1F_09860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HDN1F_09880	COG1181	Belongs to the D-alanine--D-alanine ligase family
HDN1F_09910	COG0697	spore germination
HDN1F_09940	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_09970	COG0300	oxidoreductase activity
HDN1F_09970	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_09970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HDN1F_09970	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_09970	COG3321	synthase
HDN1F_10050	COG1404	Belongs to the peptidase S8 family
HDN1F_10070	COG1024	Enoyl-CoA hydratase
HDN1F_10070	COG1250	3-hydroxyacyl-CoA dehydrogenase
HDN1F_10080	COG0183	Belongs to the thiolase family
HDN1F_10110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HDN1F_10130	COG2350	Protein conserved in bacteria
HDN1F_10140	COG2917	probably involved in intracellular septation
HDN1F_10160	COG0613	PHP domain protein
HDN1F_10170	COG0009	L-threonylcarbamoyladenylate synthase
HDN1F_10190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HDN1F_10220	COG3706	GGDEF domain
HDN1F_10230	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_10250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HDN1F_10270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HDN1F_10280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HDN1F_10290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HDN1F_10320	COG1538	Outer membrane efflux protein
HDN1F_10390	COG1960	acyl-CoA dehydrogenase activity
HDN1F_10410	COG1960	acyl-CoA dehydrogenase activity
HDN1F_10440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HDN1F_10460	COG1555	photosystem II stabilization
HDN1F_10470	COG2854	intermembrane phospholipid transfer
HDN1F_10480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HDN1F_10490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HDN1F_10570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HDN1F_10580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HDN1F_10590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HDN1F_10600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HDN1F_10610	COG0072	phenylalanine-tRNA ligase activity
HDN1F_10700	COG1024	Enoyl-CoA hydratase
HDN1F_10710	COG1960	acyl-CoA dehydrogenase activity
HDN1F_10720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HDN1F_10850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HDN1F_10860	COG4948	Mandelate Racemase Muconate Lactonizing
HDN1F_10870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HDN1F_10880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HDN1F_10890	COG5001	Diguanylate cyclase
HDN1F_10890	COG3300	MHYT domain
HDN1F_10920	COG0308	aminopeptidase N
HDN1F_10950	COG2409	Drug exporters of the RND superfamily
HDN1F_11000	COG3706	GGDEF domain
HDN1F_11020	COG1024	Enoyl-CoA hydratase
HDN1F_11040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HDN1F_11100	COG2124	cytochrome p450
HDN1F_11160	COG2137	regulation of response to DNA damage stimulus
HDN1F_11180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HDN1F_11190	COG0527	aspartate kinase activity
HDN1F_11200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HDN1F_11250	COG1278	Cold shock
HDN1F_11270	COG0515	serine threonine protein kinase
HDN1F_11270	COG2815	serine threonine protein kinase
HDN1F_11280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HDN1F_11290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HDN1F_11300	COG0705	Rhomboid family
HDN1F_11310	COG2356	endonuclease I
HDN1F_11400	COG0784	Response regulator, receiver
HDN1F_11400	COG0835	chemotaxis
HDN1F_11420	COG1815	bacterial-type flagellum-dependent cell motility
HDN1F_11430	COG1558	bacterial-type flagellum-dependent cell motility
HDN1F_11440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HDN1F_11760	COG0778	Nitroreductase
HDN1F_11790	COG1024	Enoyl-CoA hydratase
HDN1F_11820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HDN1F_11840	COG0709	Synthesizes selenophosphate from selenide and ATP
HDN1F_11860	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HDN1F_11870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HDN1F_11930	COG2217	Heavy metal translocating P-type atpase
HDN1F_11950	COG0348	domain, Protein
HDN1F_11960	COG2010	Cytochrome c
HDN1F_11990	COG3278	Belongs to the heme-copper respiratory oxidase family
HDN1F_12010	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HDN1F_12020	COG2814	Major facilitator Superfamily
HDN1F_12030	COG0425	Belongs to the sulfur carrier protein TusA family
HDN1F_12050	COG0753	catalase activity
HDN1F_12290	COG3501	Rhs element vgr protein
HDN1F_12300	COG0659	secondary active sulfate transmembrane transporter activity
HDN1F_12360	COG2862	Uncharacterized protein family, UPF0114
HDN1F_12380	COG0534	Mate efflux family protein
HDN1F_12390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HDN1F_12480	COG4787	bacterial-type flagellum-dependent cell motility
HDN1F_12490	COG4786	Flagellar basal body rod
HDN1F_12500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HDN1F_12580	COG1960	acyl-CoA dehydrogenase activity
HDN1F_12590	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_12640	COG2226	methyltransferase
HDN1F_12650	COG0587	DNA-directed DNA polymerase activity
HDN1F_12680	COG0306	phosphate transporter
HDN1F_12720	COG5002	protein histidine kinase activity
HDN1F_12720	COG2205	protein histidine kinase activity
HDN1F_12720	COG0784	Response regulator, receiver
HDN1F_12730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HDN1F_12730	COG0392	lysyltransferase activity
HDN1F_12750	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HDN1F_12760	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HDN1F_12800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HDN1F_12820	COG0589	response to stress
HDN1F_12870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HDN1F_12900	COG1472	Belongs to the glycosyl hydrolase 3 family
HDN1F_12930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HDN1F_12950	COG3118	belongs to the thioredoxin family
HDN1F_12960	COG3706	GGDEF domain
HDN1F_12960	COG4251	negative regulation of phosphorylation
HDN1F_12960	COG5001	Diguanylate cyclase
HDN1F_12960	COG2203	Gaf domain
HDN1F_12970	COG2203	Gaf domain
HDN1F_12970	COG2199	diguanylate cyclase activity
HDN1F_13060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HDN1F_13120	COG3706	GGDEF domain
HDN1F_13120	COG0745	RESPONSE REGULATOR receiver
HDN1F_13190	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_13200	COG2197	response regulator
HDN1F_13210	COG3850	Histidine kinase
HDN1F_13240	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HDN1F_13250	COG1140	nitrate reductase beta subunit
HDN1F_13260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HDN1F_13270	COG2181	nitrate reductase activity
HDN1F_13290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HDN1F_13300	COG0288	reversible hydration of carbon dioxide
HDN1F_13310	COG0745	RESPONSE REGULATOR receiver
HDN1F_13320	COG2205	protein histidine kinase activity
HDN1F_13330	COG5002	protein histidine kinase activity
HDN1F_13330	COG0784	Response regulator, receiver
HDN1F_13330	COG2205	protein histidine kinase activity
HDN1F_13350	COG0189	ligase activity
HDN1F_13360	COG4067	protein conserved in archaea
HDN1F_13360	COG0189	ligase activity
HDN1F_13370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HDN1F_13400	COG4977	sequence-specific DNA binding
HDN1F_13400	COG1917	Cupin 2, conserved barrel domain protein
HDN1F_13420	COG0028	Belongs to the TPP enzyme family
HDN1F_13480	COG1199	ATP-dependent helicase activity
HDN1F_13480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HDN1F_13510	COG0443	Heat shock 70 kDa protein
HDN1F_13520	COG0443	Heat shock 70 kDa protein
HDN1F_13530	COG0436	Aminotransferase
HDN1F_13550	COG0386	Belongs to the glutathione peroxidase family
HDN1F_13570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HDN1F_13580	COG2201	protein-glutamate methylesterase activity
HDN1F_13600	COG0840	transmembrane signaling receptor activity
HDN1F_13610	COG0840	transmembrane signaling receptor activity
HDN1F_13690	COG2067	long-chain fatty acid transport protein
HDN1F_13710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HDN1F_13720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HDN1F_13730	COG1946	Acyl-CoA thioesterase
HDN1F_13780	COG1309	transcriptional regulator
HDN1F_13810	COG0189	ligase activity
HDN1F_13810	COG4067	protein conserved in archaea
HDN1F_13830	COG2272	Belongs to the type-B carboxylesterase lipase family
HDN1F_13840	COG0142	geranyltranstransferase activity
HDN1F_13850	COG1082	Xylose isomerase domain protein TIM barrel
HDN1F_13860	COG1854	S-ribosylhomocysteine lyase activity
HDN1F_13880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HDN1F_13920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HDN1F_13940	COG0531	amino acid
HDN1F_13970	COG3344	reverse transcriptase
HDN1F_14010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HDN1F_14020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HDN1F_14040	COG0784	Response regulator, receiver
HDN1F_14040	COG2205	protein histidine kinase activity
HDN1F_14090	COG0745	RESPONSE REGULATOR receiver
HDN1F_14100	COG2205	protein histidine kinase activity
HDN1F_14170	COG0189	ligase activity
HDN1F_14180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HDN1F_14190	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HDN1F_14210	COG2010	Cytochrome c
HDN1F_14210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HDN1F_14240	COG0004	ammonium transporteR
HDN1F_14250	COG0347	Belongs to the P(II) protein family
HDN1F_14270	COG1960	acyl-CoA dehydrogenase activity
HDN1F_14300	COG1444	tRNA N-acetyltransferase activity
HDN1F_14310	COG1937	Protein conserved in bacteria
HDN1F_14320	COG2949	membrane
HDN1F_14330	COG3264	Mechanosensitive ion channel
HDN1F_14330	COG1196	nuclear chromosome segregation
HDN1F_14350	COG1960	acyl-CoA dehydrogenase activity
HDN1F_14400	COG3307	-O-antigen
HDN1F_14460	COG1643	Atp-dependent helicase
HDN1F_14500	COG1960	acyl-CoA dehydrogenase activity
HDN1F_14510	COG0745	RESPONSE REGULATOR receiver
HDN1F_14530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HDN1F_14570	COG4413	Urea transporter
HDN1F_14600	COG1960	acyl-CoA dehydrogenase activity
HDN1F_14610	COG1960	acyl-CoA dehydrogenase activity
HDN1F_14640	COG0516	GMP reductase activity
HDN1F_14730	COG1987	bacterial-type flagellum assembly
HDN1F_14780	COG0455	bacterial-type flagellum organization
HDN1F_14820	COG2198	Histidine kinase
HDN1F_14820	COG0643	Histidine kinase
HDN1F_14830	COG2201	protein-glutamate methylesterase activity
HDN1F_14840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HDN1F_14850	COG1360	Flagellar Motor Protein
HDN1F_14860	COG1192	Involved in chromosome partitioning
HDN1F_14880	COG0835	chemotaxis
HDN1F_14890	COG0835	chemotaxis
HDN1F_14910	COG2257	FlhB HrpN YscU SpaS Family
HDN1F_14930	COG4133	protoheme IX ABC transporter activity
HDN1F_14970	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HDN1F_15010	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HDN1F_15020	COG0788	formyltetrahydrofolate deformylase activity
HDN1F_15030	COG0469	pyruvate kinase activity
HDN1F_15040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HDN1F_15050	COG1132	(ABC) transporter
HDN1F_15060	COG1132	(ABC) transporter
HDN1F_15070	COG0084	hydrolase, TatD family'
HDN1F_15110	COG1538	Outer membrane efflux protein
HDN1F_15170	COG4804	nuclease activity
HDN1F_15230	COG1396	sequence-specific DNA binding
HDN1F_15260	COG0754	glutathionylspermidine amidase activity
HDN1F_15280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HDN1F_15400	COG0515	serine threonine protein kinase
HDN1F_15480	COG4964	Belongs to the GSP D family
HDN1F_15570	COG2084	Dehydrogenase
HDN1F_15620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HDN1F_15630	COG0045	succinate-CoA ligase (ADP-forming) activity
HDN1F_15680	COG1278	Cold shock
HDN1F_15690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HDN1F_15700	COG0542	response to heat
HDN1F_15710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HDN1F_15720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HDN1F_15730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HDN1F_15740	COG0492	ferredoxin-NADP+ reductase activity
HDN1F_15770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HDN1F_15780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HDN1F_15790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HDN1F_15800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HDN1F_15800	COG1648	precorrin-2 dehydrogenase activity
HDN1F_15820	COG2920	part of a sulfur-relay system
HDN1F_15850	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HDN1F_15880	COG0326	Molecular chaperone. Has ATPase activity
HDN1F_15890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HDN1F_15920	COG1022	Amp-dependent synthetase and ligase
HDN1F_15940	COG0596	Alpha beta hydrolase
HDN1F_15940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HDN1F_16000	COG2030	dehydratase
HDN1F_16050	COG2890	protein-(glutamine-N5) methyltransferase activity
HDN1F_16060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HDN1F_16070	COG2814	Major facilitator Superfamily
HDN1F_16090	COG3609	addiction module antidote protein, CC2985 family
HDN1F_16130	COG3123	guanosine phosphorylase activity
HDN1F_16150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HDN1F_16160	COG0589	response to stress
HDN1F_16170	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HDN1F_16180	COG3657	addiction module killer protein
HDN1F_16190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HDN1F_16200	COG0066	3-isopropylmalate dehydratase activity
HDN1F_16210	COG0473	3-isopropylmalate dehydrogenase activity
HDN1F_16220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HDN1F_16270	COG0135	phosphoribosylanthranilate isomerase activity
HDN1F_16280	COG0133	tryptophan synthase activity
HDN1F_16290	COG0159	tryptophan synthase activity
HDN1F_16300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HDN1F_16310	COG0285	dihydrofolate synthase activity
HDN1F_16330	COG1286	toxin biosynthetic process
HDN1F_16360	COG0714	Associated with various cellular activities
HDN1F_16400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HDN1F_16430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HDN1F_16490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HDN1F_16500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HDN1F_16510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HDN1F_16520	COG0544	peptidyl-prolyl cis-trans isomerase activity
HDN1F_16530	COG0740	serine-type endopeptidase activity
HDN1F_16540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HDN1F_16550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HDN1F_16570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HDN1F_16580	COG4172	Belongs to the ABC transporter superfamily
HDN1F_16590	COG4239	(ABC) transporter, permease
HDN1F_16600	COG4174	ABC transporter (Permease)
HDN1F_16610	COG4166	transmembrane transport
HDN1F_16620	COG4166	transmembrane transport
HDN1F_16640	COG1388	LysM domain
HDN1F_16640	COG0741	lytic transglycosylase activity
HDN1F_16650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HDN1F_16660	COG2226	methyltransferase
HDN1F_16670	COG0328	RNA-DNA hybrid ribonuclease activity
HDN1F_16680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HDN1F_16720	COG0616	signal peptide processing
HDN1F_16740	COG0316	Belongs to the HesB IscA family
HDN1F_16740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HDN1F_16750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HDN1F_16790	COG0589	response to stress
HDN1F_16830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HDN1F_16840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HDN1F_16860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HDN1F_16880	COG5001	Diguanylate cyclase
HDN1F_16880	COG5002	protein histidine kinase activity
HDN1F_16900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HDN1F_16980	COG1346	cytolysis
HDN1F_17000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HDN1F_17010	COG2885	chlorophyll binding
HDN1F_17090	COG1960	acyl-CoA dehydrogenase activity
HDN1F_17100	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_17180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HDN1F_17180	COG4651	solute:proton antiporter activity
HDN1F_17210	COG4644	lycopene metabolic process
HDN1F_17330	COG3311	Transcriptional regulator
HDN1F_17340	COG1569	PIN domain
HDN1F_17400	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_17410	COG1960	acyl-CoA dehydrogenase activity
HDN1F_17520	COG3706	GGDEF domain
HDN1F_17550	COG0633	Ferredoxin
HDN1F_17630	COG1192	Involved in chromosome partitioning
HDN1F_17640	COG1475	DNA binding
HDN1F_17790	COG2003	Belongs to the UPF0758 family
HDN1F_17830	COG2944	sequence-specific DNA binding
HDN1F_17900	COG3344	reverse transcriptase
HDN1F_18250	COG4974	Belongs to the 'phage' integrase family
HDN1F_18290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HDN1F_18300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HDN1F_18380	COG4191	Histidine kinase
HDN1F_18400	COG2391	methyltransferase activity
HDN1F_18410	COG0425	Belongs to the sulfur carrier protein TusA family
HDN1F_18420	COG0583	DNA-binding transcription factor activity
HDN1F_18440	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HDN1F_18490	COG0012	GTP binding
HDN1F_18500	COG0193	aminoacyl-tRNA hydrolase activity
HDN1F_18510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HDN1F_18520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HDN1F_18530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HDN1F_18540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HDN1F_18580	COG4691	Plasmid stability protein
HDN1F_18590	COG1487	ribonuclease activity
HDN1F_18610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HDN1F_18620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HDN1F_18640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HDN1F_18650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_18660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_18670	COG0649	NAD binding
HDN1F_18670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_18680	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HDN1F_18700	COG1034	ATP synthesis coupled electron transport
HDN1F_18720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_18730	COG0839	Belongs to the complex I subunit 6 family
HDN1F_18740	COG0713	ATP synthesis coupled electron transport
HDN1F_18770	COG1007	ATP synthesis coupled electron transport
HDN1F_18790	COG0514	ATP-dependent DNA helicase (RecQ)
HDN1F_18800	COG2200	EAL domain
HDN1F_18800	COG2199	diguanylate cyclase activity
HDN1F_18800	COG3287	FIST C domain
HDN1F_18820	COG1509	lysine 2,3-aminomutase activity
HDN1F_18830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HDN1F_18870	COG5640	endopeptidase activity
HDN1F_18880	COG0688	phosphatidylethanolamine metabolic process
HDN1F_18910	COG1360	Flagellar Motor Protein
HDN1F_18920	COG1162	GTPase activity
HDN1F_18940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HDN1F_18940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HDN1F_18950	COG0802	atpase or kinase
HDN1F_18970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HDN1F_18980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HDN1F_19000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HDN1F_19010	COG1011	Hydrolase
HDN1F_19020	COG0494	nUDIX hydrolase
HDN1F_19030	COG1218	3'(2'),5'-bisphosphate nucleotidase
HDN1F_19040	COG0529	Catalyzes the synthesis of activated sulfate
HDN1F_19080	COG0583	DNA-binding transcription factor activity
HDN1F_19130	COG4191	Histidine kinase
HDN1F_19140	COG4566	intracellular signal transduction
HDN1F_19150	COG2198	Histidine kinase
HDN1F_19150	COG0643	Histidine kinase
HDN1F_19160	COG0840	transmembrane signaling receptor activity
HDN1F_19170	COG0835	chemotaxis
HDN1F_19190	COG4399	Belongs to the UPF0754 family
HDN1F_19250	COG0745	RESPONSE REGULATOR receiver
HDN1F_19250	COG3706	GGDEF domain
HDN1F_19270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HDN1F_19410	COG3436	PFAM IS66 Orf2 family protein
HDN1F_19420	COG4372	Transposase
HDN1F_19470	COG0742	ribosomal rna small subunit methyltransferase
HDN1F_19480	COG0612	Peptidase, M16
HDN1F_19490	COG0612	Peptidase, M16
HDN1F_19510	COG0552	protein localization to endoplasmic reticulum
HDN1F_19520	COG2884	Cell division ATP-binding protein ftsE
HDN1F_19530	COG2177	Part of the ABC transporter FtsEX involved in
HDN1F_19630	COG0515	serine threonine protein kinase
HDN1F_19640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HDN1F_19650	COG0583	DNA-binding transcription factor activity
HDN1F_19660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HDN1F_19670	COG2982	Protein involved in outer membrane biogenesis
HDN1F_19680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HDN1F_19680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HDN1F_19730	COG2124	cytochrome p450
HDN1F_19750	COG1960	acyl-CoA dehydrogenase activity
HDN1F_19760	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_19770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HDN1F_19800	COG1960	acyl-CoA dehydrogenase activity
HDN1F_19860	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_19870	COG1053	succinate dehydrogenase
HDN1F_19870	COG3976	FMN-binding domain protein
HDN1F_19880	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_19930	COG2151	metal-sulfur cluster biosynthetic enzyme
HDN1F_19980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HDN1F_20000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HDN1F_20010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HDN1F_20020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HDN1F_20030	COG0617	tRNA 3'-terminal CCA addition
HDN1F_20090	COG0243	molybdopterin cofactor binding
HDN1F_20100	COG1140	nitrate reductase beta subunit
HDN1F_20110	COG2010	Cytochrome c
HDN1F_20130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HDN1F_20150	COG4372	Transposase
HDN1F_20160	COG3436	PFAM IS66 Orf2 family protein
HDN1F_20180	COG2198	Histidine kinase
HDN1F_20180	COG0643	Histidine kinase
HDN1F_20190	COG0259	pyridoxamine-phosphate oxidase activity
HDN1F_20220	COG4794	Type iii secretion
HDN1F_20230	COG4790	Type iii secretion
HDN1F_20240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HDN1F_20250	COG4566	intracellular signal transduction
HDN1F_20260	COG4191	Histidine kinase
HDN1F_20390	COG0473	3-isopropylmalate dehydrogenase activity
HDN1F_20400	COG0288	reversible hydration of carbon dioxide
HDN1F_20470	COG3604	Transcriptional regulator
HDN1F_20480	COG0840	transmembrane signaling receptor activity
HDN1F_20510	COG1959	2 iron, 2 sulfur cluster binding
HDN1F_20540	COG2813	Specifically methylates the guanine in position
HDN1F_20550	COG1187	pseudouridine synthase activity
HDN1F_20580	COG2198	Histidine kinase
HDN1F_20580	COG0643	Histidine kinase
HDN1F_20590	COG0745	RESPONSE REGULATOR receiver
HDN1F_20620	COG0280	phosphate acetyltransferase
HDN1F_20620	COG0281	malic enzyme
HDN1F_20630	COG0861	Integral membrane protein TerC family
HDN1F_20640	COG0784	Response regulator, receiver
HDN1F_20640	COG2205	protein histidine kinase activity
HDN1F_20660	COG2205	protein histidine kinase activity
HDN1F_20660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HDN1F_20670	COG0784	Response regulator, receiver
HDN1F_20670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HDN1F_20670	COG2198	Histidine kinase
HDN1F_20670	COG2205	protein histidine kinase activity
HDN1F_20680	COG5002	protein histidine kinase activity
HDN1F_20680	COG2205	protein histidine kinase activity
HDN1F_20680	COG0784	Response regulator, receiver
HDN1F_20710	COG2154	pterin-4-alpha-carbinolamine dehydratase
HDN1F_20720	COG1047	Peptidyl-prolyl cis-trans
HDN1F_20730	COG3300	MHYT domain
HDN1F_20730	COG5001	Diguanylate cyclase
HDN1F_20740	COG1490	D-aminoacyl-tRNA deacylase activity
HDN1F_20750	COG2719	SpoVR family
HDN1F_20760	COG2718	Belongs to the UPF0229 family
HDN1F_20770	COG2766	serine protein kinase
HDN1F_20780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HDN1F_20800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HDN1F_20810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HDN1F_20820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HDN1F_20830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HDN1F_20850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HDN1F_20860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HDN1F_20950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HDN1F_20960	COG0546	phosphoglycolate phosphatase activity
HDN1F_20980	COG1002	Type II restriction enzyme, methylase subunits
HDN1F_21000	COG4804	nuclease activity
HDN1F_21010	COG1061	Type III restriction enzyme res subunit
HDN1F_21020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HDN1F_21090	COG0512	Glutamine amidotransferase of anthranilate synthase
HDN1F_21130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HDN1F_21140	COG1923	regulation of RNA biosynthetic process
HDN1F_21150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HDN1F_21160	COG0330	HflC and HflK could
HDN1F_21170	COG0330	HflC and HflK could
HDN1F_21250	COG2166	iron-sulfur cluster assembly
HDN1F_21260	COG2151	metal-sulfur cluster biosynthetic enzyme
HDN1F_21270	COG0316	Belongs to the HesB IscA family
HDN1F_21280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HDN1F_21290	COG0719	Fe-S assembly protein
HDN1F_21300	COG0396	ATPase activity
HDN1F_21310	COG0719	Fe-S assembly protein
HDN1F_21320	COG1959	2 iron, 2 sulfur cluster binding
HDN1F_21360	COG0534	Mate efflux family protein
HDN1F_21380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_21390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HDN1F_21500	COG1309	transcriptional regulator
HDN1F_21510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HDN1F_21520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_21590	COG0795	lipopolysaccharide-transporting ATPase activity
HDN1F_21600	COG0795	lipopolysaccharide-transporting ATPase activity
HDN1F_21620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HDN1F_21630	COG0343	queuine tRNA-ribosyltransferase activity
HDN1F_21640	COG1862	Preprotein translocase
HDN1F_21720	COG1104	cysteine desulfurase activity
HDN1F_21740	COG0105	UTP biosynthetic process
HDN1F_21750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HDN1F_21780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HDN1F_21790	COG0124	histidyl-tRNA synthetase
HDN1F_21800	COG2976	Protein conserved in bacteria
HDN1F_21820	COG1160	GTP binding
HDN1F_21840	COG2909	trisaccharide binding
HDN1F_21970	COG1404	Belongs to the peptidase S8 family
HDN1F_22020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HDN1F_22030	COG2204	response regulator
HDN1F_22040	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_22090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HDN1F_22100	COG1960	acyl-CoA dehydrogenase activity
HDN1F_22120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HDN1F_22120	COG0519	Catalyzes the synthesis of GMP from XMP
HDN1F_22140	COG1196	nuclear chromosome segregation
HDN1F_22210	COG1595	DNA-templated transcription, initiation
HDN1F_22230	COG0513	Belongs to the DEAD box helicase family
HDN1F_22250	COG0598	Magnesium transport protein CorA
HDN1F_22260	COG0590	tRNA wobble adenosine to inosine editing
HDN1F_22280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HDN1F_22350	COG0494	nUDIX hydrolase
HDN1F_22370	COG4536	flavin adenine dinucleotide binding
HDN1F_22390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HDN1F_22400	COG0228	four-way junction DNA binding
HDN1F_22410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HDN1F_22420	COG0336	Belongs to the RNA methyltransferase TrmD family
HDN1F_22450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HDN1F_22470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HDN1F_22480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HDN1F_22510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HDN1F_22530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HDN1F_22540	COG0724	RNA recognition motif
HDN1F_22570	COG1024	Enoyl-CoA hydratase
HDN1F_22590	COG0778	Nitroreductase
HDN1F_22600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HDN1F_22600	COG2755	lipolytic protein G-D-S-L family
HDN1F_22650	COG0745	RESPONSE REGULATOR receiver
HDN1F_22670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HDN1F_22680	COG0581	inorganic phosphate transmembrane transporter activity
HDN1F_22690	COG0573	inorganic phosphate transmembrane transporter activity
HDN1F_22720	COG2814	Major facilitator Superfamily
HDN1F_22730	COG1566	PFAM secretion protein HlyD family protein
HDN1F_22740	COG1846	Transcriptional regulator
HDN1F_22750	COG3093	addiction module antidote protein HigA
HDN1F_22770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HDN1F_22790	COG2226	methyltransferase
HDN1F_22820	COG4221	oxidoreductase activity
HDN1F_22830	COG1064	alcohol dehydrogenase
HDN1F_22870	COG1943	Transposase
HDN1F_22900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HDN1F_23030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HDN1F_23040	COG2914	Belongs to the UPF0125 (RnfH) family
HDN1F_23050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HDN1F_23070	COG0497	DNA recombination
HDN1F_23100	COG1388	LysM domain
HDN1F_23120	COG4279	zinc finger
HDN1F_23130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HDN1F_23180	COG1420	regulation of RNA biosynthetic process
HDN1F_23190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HDN1F_23200	COG0443	Heat shock 70 kDa protein
HDN1F_23210	COG0484	heat shock protein binding
HDN1F_23220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HDN1F_23250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HDN1F_23260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HDN1F_23270	COG0254	rRNA binding
HDN1F_23350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HDN1F_23360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HDN1F_23380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HDN1F_23400	COG2026	Addiction module toxin, RelE StbE family
HDN1F_23410	COG0586	Pfam SNARE associated Golgi protein
HDN1F_23490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HDN1F_23500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HDN1F_23510	COG0140	phosphoribosyl-ATP diphosphatase activity
HDN1F_23520	COG2226	methyltransferase
HDN1F_23540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HDN1F_23550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HDN1F_23580	COG0018	arginyl-trna synthetase
HDN1F_23620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HDN1F_23630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HDN1F_23680	COG2274	protein secretion by the type I secretion system
HDN1F_23720	COG0557	exoribonuclease II activity
HDN1F_23730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HDN1F_23740	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HDN1F_23770	COG5445	Predicted secreted protein (DUF2300)
HDN1F_23780	COG4676	Protein conserved in bacteria
HDN1F_23790	COG4792	protein secretion
HDN1F_23840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HDN1F_23860	COG0359	binds to the 23S rRNA
HDN1F_23940	COG1805	sodium ion transport
HDN1F_23970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HDN1F_23990	COG1477	protein flavinylation
HDN1F_24010	COG0305	Participates in initiation and elongation during chromosome replication
HDN1F_24020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HDN1F_24090	COG2995	paraquat-inducible protein a
HDN1F_24100	COG2995	paraquat-inducible protein a
HDN1F_24110	COG3008	intermembrane lipid transfer
HDN1F_24130	COG0728	peptidoglycan biosynthetic process
HDN1F_24180	COG0589	response to stress
HDN1F_24240	COG5001	Diguanylate cyclase
HDN1F_24250	COG1595	DNA-templated transcription, initiation
HDN1F_24260	COG0302	gtp cyclohydrolase
HDN1F_24270	COG1297	OPT oligopeptide transporter protein
HDN1F_24330	COG1840	ABC-type Fe3 transport system, periplasmic component
HDN1F_24340	COG1178	ABC-type Fe3 transport system permease component
HDN1F_24350	COG3842	ATPase activity
HDN1F_24360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HDN1F_24390	COG0488	(ABC) transporter
HDN1F_24410	COG3122	Protein conserved in bacteria
HDN1F_24450	COG2363	Small membrane protein
HDN1F_24460	COG2827	Endonuclease containing a URI domain
HDN1F_24510	COG2951	lytic endotransglycosylase activity
HDN1F_24530	COG0217	transcriptional regulatory protein
HDN1F_24550	COG0840	transmembrane signaling receptor activity
HDN1F_24590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HDN1F_24620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HDN1F_24630	COG0784	Response regulator, receiver
HDN1F_24630	COG2205	protein histidine kinase activity
HDN1F_24630	COG2198	Histidine kinase
HDN1F_24670	COG1132	(ABC) transporter
HDN1F_24740	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_24760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HDN1F_24830	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_24850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HDN1F_24860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HDN1F_24870	COG0204	Acyl-transferase
HDN1F_24940	COG2258	MOSC domain
HDN1F_24950	COG2863	cytochrome
HDN1F_24960	COG3258	Cytochrome c
HDN1F_24970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HDN1F_25020	COG2807	transmembrane transport
HDN1F_25040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HDN1F_25130	COG0297	glycogen (starch) synthase activity
HDN1F_25130	COG0438	transferase activity, transferring glycosyl groups
HDN1F_25240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HDN1F_25250	COG0243	molybdopterin cofactor binding
HDN1F_25260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HDN1F_25270	COG2223	nitrite transmembrane transporter activity
HDN1F_25300	COG0840	transmembrane signaling receptor activity
HDN1F_25330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HDN1F_25340	COG1393	Belongs to the ArsC family
HDN1F_25350	COG0025	NhaP-type Na H and K H
HDN1F_25370	COG2391	methyltransferase activity
HDN1F_25380	COG2391	methyltransferase activity
HDN1F_25390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HDN1F_25400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HDN1F_25400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HDN1F_25430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HDN1F_25530	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HDN1F_25540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HDN1F_25550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HDN1F_25590	COG3119	arylsulfatase activity
HDN1F_25600	COG5002	protein histidine kinase activity
HDN1F_25610	COG0745	RESPONSE REGULATOR receiver
HDN1F_25660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HDN1F_25670	COG0463	Glycosyl transferase, family 2
HDN1F_25740	COG0784	Response regulator, receiver
HDN1F_25740	COG5002	protein histidine kinase activity
HDN1F_25770	COG1943	Transposase
HDN1F_25800	COG0824	Thioesterase
HDN1F_25810	COG1454	alcohol dehydrogenase
HDN1F_25830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HDN1F_25840	COG0142	geranyltranstransferase activity
HDN1F_25890	COG5001	Diguanylate cyclase
HDN1F_25890	COG5002	protein histidine kinase activity
HDN1F_25900	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HDN1F_25910	COG3657	addiction module killer protein
HDN1F_25940	COG1966	Carbon starvation protein
HDN1F_25950	COG2879	small protein
HDN1F_25960	COG2827	Endonuclease containing a URI domain
HDN1F_25980	COG4771	TonB-dependent receptor
HDN1F_26030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HDN1F_26050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HDN1F_26060	COG2894	cell division
HDN1F_26070	COG0850	regulation of cytokinetic process
HDN1F_26100	COG5002	protein histidine kinase activity
HDN1F_26100	COG2205	protein histidine kinase activity
HDN1F_26100	COG0784	Response regulator, receiver
HDN1F_26110	COG0517	IMP dehydrogenase activity
HDN1F_26120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_26130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_26140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_26140	COG0649	NAD binding
HDN1F_26180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HDN1F_26190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_26220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HDN1F_26230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HDN1F_26240	COG1007	ATP synthesis coupled electron transport
HDN1F_26270	COG1797	cobyrinic acid a,c-diamide synthase activity
HDN1F_26310	COG2099	Precorrin-6x reductase
HDN1F_26390	COG1120	ATPase activity
HDN1F_26400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HDN1F_26420	COG4774	siderophore transport
HDN1F_26440	COG0151	Belongs to the GarS family
HDN1F_26470	COG0840	transmembrane signaling receptor activity
HDN1F_26500	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HDN1F_26580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HDN1F_26620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HDN1F_26630	COG2885	chlorophyll binding
HDN1F_26660	COG0840	transmembrane signaling receptor activity
HDN1F_26750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HDN1F_26820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HDN1F_26840	COG1946	Acyl-CoA thioesterase
HDN1F_26850	COG1012	belongs to the aldehyde dehydrogenase family
HDN1F_26930	COG1320	monovalent cation:proton antiporter activity
HDN1F_26940	COG2212	antiporter activity
HDN1F_26950	COG1863	multisubunit Na H antiporter MnhE subunit
HDN1F_26960	COG0651	ATP synthesis coupled electron transport
HDN1F_26970	COG1006	Multisubunit Na H antiporter MnhC subunit
HDN1F_26980	COG2111	Na H antiporter
HDN1F_26980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HDN1F_26990	COG1283	sodium-dependent phosphate transmembrane transporter activity
HDN1F_27000	COG0733	neurotransmitter:sodium symporter activity
HDN1F_27010	COG1295	ribonuclease BN
HDN1F_27080	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HDN1F_27120	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HDN1F_27180	COG2197	response regulator
HDN1F_27200	COG5001	Diguanylate cyclase
HDN1F_27200	COG3706	GGDEF domain
HDN1F_27200	COG2203	Gaf domain
HDN1F_27200	COG4251	negative regulation of phosphorylation
HDN1F_27210	COG3278	Belongs to the heme-copper respiratory oxidase family
HDN1F_27240	COG2010	Cytochrome c
HDN1F_27270	COG5001	Diguanylate cyclase
HDN1F_27270	COG3300	MHYT domain
HDN1F_27310	COG0784	Response regulator, receiver
HDN1F_27310	COG3437	response regulator, receiver
HDN1F_27320	COG2264	protein methyltransferase activity
HDN1F_27330	COG1994	Peptidase M50
HDN1F_27350	COG4804	nuclease activity
HDN1F_27360	COG0346	lactoylglutathione lyase activity
HDN1F_27430	COG1024	Enoyl-CoA hydratase
HDN1F_27440	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27450	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27460	COG0183	Belongs to the thiolase family
HDN1F_27470	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_27480	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27490	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27520	COG0840	transmembrane signaling receptor activity
HDN1F_27530	COG1573	uracil-dna glycosylase
HDN1F_27550	COG0358	DNA primase activity
HDN1F_27560	COG1610	YqeY-like protein
HDN1F_27570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HDN1F_27580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HDN1F_27590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HDN1F_27600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HDN1F_27610	COG0302	gtp cyclohydrolase
HDN1F_27610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HDN1F_27620	COG0617	tRNA 3'-terminal CCA addition
HDN1F_27630	COG2226	methyltransferase
HDN1F_27660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HDN1F_27670	COG4221	oxidoreductase activity
HDN1F_27700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HDN1F_27770	COG0741	lytic transglycosylase activity
HDN1F_27790	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27800	COG1960	acyl-CoA dehydrogenase activity
HDN1F_27860	COG1360	Flagellar Motor Protein
HDN1F_27950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HDN1F_28000	COG0347	Belongs to the P(II) protein family
HDN1F_28020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HDN1F_28030	COG1166	arginine decarboxylase activity
HDN1F_28050	COG1519	Transferase
HDN1F_28060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HDN1F_28090	COG1492	cobalamin metabolic process
HDN1F_28110	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_28130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HDN1F_28160	COG3300	MHYT domain
HDN1F_28160	COG5001	Diguanylate cyclase
HDN1F_28170	COG5001	Diguanylate cyclase
HDN1F_28170	COG2203	Gaf domain
HDN1F_28170	COG3706	GGDEF domain
HDN1F_28170	COG4251	negative regulation of phosphorylation
HDN1F_28190	COG0024	Methionine aminopeptidase
HDN1F_28200	COG0052	Belongs to the universal ribosomal protein uS2 family
HDN1F_28210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HDN1F_28220	COG0528	UMP kinase activity
HDN1F_28230	COG0233	cytoplasmic translational termination
HDN1F_28240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HDN1F_28260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HDN1F_28270	COG0750	zinc metalloprotease
HDN1F_28310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HDN1F_28320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HDN1F_28330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HDN1F_28340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HDN1F_28350	COG0587	DNA-directed DNA polymerase activity
HDN1F_28360	COG0825	malonyl-CoA metabolic process
HDN1F_28370	COG0730	response to heat
HDN1F_28410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HDN1F_28420	COG1138	Cytochrome C-type biogenesis protein
HDN1F_28470	COG0563	adenylate kinase activity
HDN1F_28480	COG0746	molybdenum cofactor guanylyltransferase activity
HDN1F_28490	COG1214	PFAM Peptidase M22, glycoprotease
HDN1F_28510	COG0742	ribosomal rna small subunit methyltransferase
HDN1F_28530	COG1131	(ABC) transporter
HDN1F_28560	COG0037	tRNA processing
HDN1F_28600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HDN1F_28610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HDN1F_28630	COG0585	pseudouridine synthase activity
HDN1F_28690	COG0519	Catalyzes the synthesis of GMP from XMP
HDN1F_28710	COG2205	protein histidine kinase activity
HDN1F_28710	COG0784	Response regulator, receiver
HDN1F_28710	COG2198	Histidine kinase
HDN1F_28720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HDN1F_28730	COG1074	ATP-dependent DNA helicase activity
HDN1F_28740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HDN1F_28760	COG1960	acyl-CoA dehydrogenase activity
HDN1F_28770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HDN1F_28800	COG1115	amino acid carrier protein
HDN1F_28830	COG4221	oxidoreductase activity
HDN1F_28880	COG3266	domain, Protein
HDN1F_28890	COG3150	esterase
HDN1F_29030	COG2815	serine threonine protein kinase
HDN1F_29030	COG0515	serine threonine protein kinase
HDN1F_29060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HDN1F_29100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HDN1F_29110	COG4251	negative regulation of phosphorylation
HDN1F_29110	COG5001	Diguanylate cyclase
HDN1F_29110	COG3706	GGDEF domain
HDN1F_29110	COG2203	Gaf domain
HDN1F_29130	COG3038	cytochrome b561
HDN1F_29140	COG0840	transmembrane signaling receptor activity
HDN1F_29160	COG1960	acyl-CoA dehydrogenase activity
HDN1F_29180	COG0204	Acyl-transferase
HDN1F_29200	COG0501	Belongs to the peptidase M48B family
HDN1F_29210	COG1704	LemA family
HDN1F_29230	COG1469	GTP cyclohydrolase I activity
HDN1F_29250	COG1765	OsmC-like protein
HDN1F_29260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HDN1F_29270	COG0588	phosphoglycerate mutase activity
HDN1F_29370	COG0302	gtp cyclohydrolase
HDN1F_29390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HDN1F_29400	COG0577	efflux transmembrane transporter activity
HDN1F_29400	COG1136	(ABC) transporter
HDN1F_29410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HDN1F_29410	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HDN1F_29420	COG1233	COG1233 Phytoene dehydrogenase and related
HDN1F_29440	COG1845	cytochrome c oxidase, subunit III
HDN1F_29490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HDN1F_29500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HDN1F_29510	COG0500	methyltransferase
HDN1F_29520	COG1131	(ABC) transporter
HDN1F_29530	COG0842	Transport permease protein
HDN1F_29540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HDN1F_29540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HDN1F_29630	COG3344	reverse transcriptase
HDN1F_29730	COG3436	PFAM IS66 Orf2 family protein
HDN1F_29740	COG4372	Transposase
HDN1F_29800	COG3344	reverse transcriptase
HDN1F_29810	COG4372	Transposase
HDN1F_29820	COG3436	PFAM IS66 Orf2 family protein
HDN1F_29930	COG3344	reverse transcriptase
HDN1F_30010	COG1403	HNH endonuclease
HDN1F_30080	COG3344	reverse transcriptase
HDN1F_30170	COG0811	peptide transport
HDN1F_30210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HDN1F_30230	COG0501	Belongs to the peptidase M48B family
HDN1F_30250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HDN1F_30260	COG2855	membrane
HDN1F_30270	COG0583	DNA-binding transcription factor activity
HDN1F_30290	COG3115	cell septum assembly
HDN1F_30300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HDN1F_30320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HDN1F_30320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HDN1F_30350	COG3134	Outer membrane lipoprotein
HDN1F_30390	COG0183	Belongs to the thiolase family
HDN1F_30400	COG1250	3-hydroxyacyl-CoA dehydrogenase
HDN1F_30400	COG1024	Enoyl-CoA hydratase
HDN1F_30460	COG0714	Associated with various cellular activities
HDN1F_30550	COG2124	cytochrome p450
HDN1F_30560	COG0672	)-iron permease
HDN1F_30570	COG0471	metal ion transport
HDN1F_30590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HDN1F_30600	COG0456	acetyltransferase
HDN1F_30610	COG1846	Transcriptional regulator
HDN1F_30640	COG1968	undecaprenyl-diphosphatase activity
HDN1F_30660	COG1304	FMN binding
HDN1F_30690	COG0436	Aminotransferase
HDN1F_30710	COG0070	glutamate synthase
HDN1F_30710	COG0069	glutamate synthase activity
HDN1F_30710	COG0067	glutamate synthase
HDN1F_30720	COG3609	addiction module antidote protein, CC2985 family
HDN1F_30760	COG3852	Histidine kinase
HDN1F_30770	COG0174	glutamine synthetase
HDN1F_30800	COG0237	dephospho-CoA kinase activity
HDN1F_30810	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HDN1F_30820	COG3657	addiction module killer protein
HDN1F_30880	COG4680	protein conserved in bacteria
HDN1F_30890	COG5499	transcription regulator containing HTH domain
HDN1F_30970	COG3830	Belongs to the UPF0237 family
HDN1F_30970	COG0560	Phosphoserine phosphatase
HDN1F_31010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HDN1F_31080	COG4453	Protein conserved in bacteria
HDN1F_31090	COG3177	Filamentation induced by cAMP protein fic
HDN1F_31110	COG3344	reverse transcriptase
HDN1F_31140	COG0431	NADPH-dependent FMN reductase
HDN1F_31190	COG0840	transmembrane signaling receptor activity
HDN1F_31200	COG0071	Belongs to the small heat shock protein (HSP20) family
HDN1F_31250	COG1309	transcriptional regulator
HDN1F_31280	COG1136	(ABC) transporter
HDN1F_31410	COG4456	Virulence-associated protein
HDN1F_31460	COG0167	dihydroorotate dehydrogenase activity
HDN1F_31490	COG2337	Toxic component of a toxin-antitoxin (TA) module
HDN1F_31500	COG0116	Belongs to the methyltransferase superfamily
HDN1F_31500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HDN1F_31630	COG2204	response regulator
HDN1F_31640	COG4191	Histidine kinase
HDN1F_31650	COG2204	response regulator
HDN1F_31660	COG1677	Flagellar hook-basal body complex protein FliE
HDN1F_31720	COG0745	RESPONSE REGULATOR receiver
HDN1F_31730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HDN1F_31760	COG0745	RESPONSE REGULATOR receiver
HDN1F_31860	COG0489	protein tyrosine kinase activity
HDN1F_31870	COG1960	acyl-CoA dehydrogenase activity
HDN1F_31890	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HDN1F_31920	COG0028	Belongs to the TPP enzyme family
HDN1F_31930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HDN1F_31960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HDN1F_31970	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HDN1F_32010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HDN1F_32060	COG0730	response to heat
HDN1F_32070	COG1028	Short-chain dehydrogenase reductase Sdr
HDN1F_32090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HDN1F_32090	COG1902	pentaerythritol trinitrate reductase activity
HDN1F_32100	COG0564	pseudouridine synthase activity
HDN1F_32110	COG0084	hydrolase, TatD family'
HDN1F_32140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HDN1F_32150	COG1067	ATP-dependent peptidase activity
HDN1F_32160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HDN1F_32240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HDN1F_32250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HDN1F_32260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HDN1F_32300	COG0840	transmembrane signaling receptor activity
HDN1F_32310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HDN1F_32330	COG0017	Asparaginyl-tRNA synthetase
HDN1F_32340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HDN1F_32360	COG0137	argininosuccinate synthase activity
HDN1F_32380	COG5001	Diguanylate cyclase
HDN1F_32390	COG2835	tetraacyldisaccharide 4'-kinase activity
HDN1F_32400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HDN1F_32410	COG2878	Part of a membrane complex involved in electron transport
HDN1F_32420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HDN1F_32420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HDN1F_32430	COG0489	protein tyrosine kinase activity
HDN1F_32440	COG0717	Belongs to the dCTP deaminase family
HDN1F_32450	COG0861	Integral membrane protein TerC family
HDN1F_32500	COG4372	Transposase
HDN1F_32510	COG3436	PFAM IS66 Orf2 family protein
HDN1F_32540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HDN1F_32570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HDN1F_32610	COG0714	Associated with various cellular activities
HDN1F_32670	COG1393	Belongs to the ArsC family
HDN1F_32720	COG3706	GGDEF domain
HDN1F_32730	COG0442	prolyl-tRNA aminoacylation
HDN1F_32750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HDN1F_32770	COG0632	four-way junction helicase activity
HDN1F_32780	COG2255	four-way junction helicase activity
HDN1F_32790	COG0824	Thioesterase
HDN1F_32830	COG0823	Involved in the tonB-independent uptake of proteins
HDN1F_32840	COG2885	chlorophyll binding
HDN1F_32860	COG0602	queuosine metabolic process
HDN1F_32870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HDN1F_32900	COG4783	chaperone-mediated protein folding
HDN1F_32910	COG0425	Belongs to the sulfur carrier protein TusA family
HDN1F_32930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HDN1F_32940	COG2716	regulation of RNA biosynthetic process
HDN1F_32970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HDN1F_33010	COG1309	transcriptional regulator
HDN1F_33030	COG1805	sodium ion transport
HDN1F_33060	COG0584	glycerophosphoryl diester phosphodiesterase
HDN1F_33070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HDN1F_33100	COG4591	ABC-type transport system involved in lipoprotein release permease component
HDN1F_33130	COG0811	peptide transport
HDN1F_33140	COG0848	biopolymer transport protein
HDN1F_33150	COG1663	tetraacyldisaccharide 4'-kinase activity
HDN1F_33160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HDN1F_33170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HDN1F_33180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HDN1F_33190	COG1530	ribonuclease E activity
HDN1F_33220	COG0546	phosphoglycolate phosphatase activity
HDN1F_33230	COG0616	signal peptide processing
HDN1F_33230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HDN1F_33250	COG0424	maF-like protein
HDN1F_33260	COG1399	metal-binding, possibly nucleic acid-binding protein
HDN1F_33270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HDN1F_33280	COG0416	fatty acid biosynthetic process
HDN1F_33320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HDN1F_33330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HDN1F_33340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HDN1F_33350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HDN1F_33380	COG1322	Protein conserved in bacteria
HDN1F_33390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HDN1F_33440	COG2205	protein histidine kinase activity
HDN1F_33440	COG5002	protein histidine kinase activity
HDN1F_33440	COG0784	Response regulator, receiver
HDN1F_33480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HDN1F_33540	COG4399	Belongs to the UPF0754 family
HDN1F_33560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HDN1F_33570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HDN1F_33580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HDN1F_33600	COG1960	acyl-CoA dehydrogenase activity
HDN1F_33610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HDN1F_33620	COG3100	YcgL domain-containing protein
HDN1F_33680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HDN1F_33700	COG2030	dehydratase
HDN1F_33720	COG0318	PFAM AMP-dependent synthetase and ligase
HDN1F_33730	COG1643	Atp-dependent helicase
HDN1F_33810	COG2197	response regulator
HDN1F_33830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HDN1F_33840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HDN1F_33870	COG2204	response regulator
HDN1F_33900	COG2205	protein histidine kinase activity
HDN1F_33910	COG0745	RESPONSE REGULATOR receiver
HDN1F_33930	COG1230	cation diffusion facilitator family transporter
HDN1F_33940	COG1070	Carbohydrate kinase
HDN1F_33950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HDN1F_33960	COG0277	FAD linked oxidase domain protein
HDN1F_33980	COG0300	oxidoreductase activity
HDN1F_33990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HDN1F_34070	COG1051	belongs to the nudix hydrolase family
HDN1F_34070	COG1056	cytidyltransferase-related domain
HDN1F_34090	COG0631	protein serine/threonine phosphatase activity
HDN1F_34150	COG0545	Peptidyl-prolyl cis-trans isomerase
HDN1F_34170	COG0739	heme binding
HDN1F_34180	COG1570	exodeoxyribonuclease VII activity
HDN1F_34210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HDN1F_34220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HDN1F_34240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HDN1F_34250	COG1960	acyl-CoA dehydrogenase activity
HDN1F_34260	COG0789	Transcriptional regulator
HDN1F_34280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HDN1F_34290	COG0039	L-malate dehydrogenase activity
HDN1F_34320	COG0271	Belongs to the BolA IbaG family
HDN1F_34350	COG0037	tRNA processing
HDN1F_34360	COG0700	Nucleoside recognition
HDN1F_34410	COG2850	peptidyl-arginine hydroxylation
HDN1F_34440	COG0482	sulfurtransferase activity
HDN1F_34460	COG0315	cyclic pyranopterin monophosphate synthase activity
HDN1F_34470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HDN1F_34480	COG0314	molybdopterin synthase activity
HDN1F_34490	COG0446	pyridine nucleotide-disulphide oxidoreductase
HDN1F_34500	COG2197	response regulator
HDN1F_34510	COG0322	excinuclease ABC activity
HDN1F_34520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HDN1F_34530	COG1611	Belongs to the LOG family
HDN1F_34560	COG5001	Diguanylate cyclase
HDN1F_34560	COG5002	protein histidine kinase activity
HDN1F_34610	COG2204	response regulator
HDN1F_34670	COG0166	Belongs to the GPI family
HDN1F_34780	COG3267	Type II secretory pathway component ExeA
HDN1F_34780	COG3409	Peptidoglycan-binding domain 1 protein
HDN1F_34810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HDN1F_34830	COG2354	Protein conserved in bacteria
HDN1F_34860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HDN1F_34870	COG1309	transcriptional regulator
HDN1F_34940	COG4974	Belongs to the 'phage' integrase family
HDN1F_35290	COG3344	reverse transcriptase
HDN1F_35360	COG2944	sequence-specific DNA binding
HDN1F_35400	COG2003	Belongs to the UPF0758 family
HDN1F_35550	COG1475	DNA binding
HDN1F_35560	COG1192	Involved in chromosome partitioning
HDN1F_35680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HDN1F_35710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HDN1F_35720	COG0741	lytic transglycosylase activity
HDN1F_35770	COG2267	carboxylic ester hydrolase activity
HDN1F_35780	COG0477	Major facilitator Superfamily
HDN1F_35800	COG1376	ErfK ybiS ycfS ynhG family protein
HDN1F_35810	COG0418	dihydroorotase activity
HDN1F_35820	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HDN1F_35830	COG4181	ATPase activity
HDN1F_35850	COG2918	glutathione biosynthetic process
HDN1F_35860	COG3130	regulation of translation
HDN1F_35870	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HDN1F_35910	COG0488	(ABC) transporter
HDN1F_35930	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HDN1F_35980	COG0840	transmembrane signaling receptor activity
HDN1F_36010	COG2205	protein histidine kinase activity
HDN1F_36030	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HDN1F_36040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HDN1F_36080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HDN1F_36160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HDN1F_36170	COG1473	amidohydrolase
HDN1F_36180	COG4771	TonB-dependent receptor
HDN1F_36250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HDN1F_36260	COG2022	thiamine diphosphate biosynthetic process
HDN1F_36280	COG0454	-acetyltransferase
HDN1F_36330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HDN1F_36400	COG1960	acyl-CoA dehydrogenase activity
HDN1F_36430	COG0191	fructose-bisphosphate aldolase activity
HDN1F_36440	COG0126	phosphoglycerate kinase activity
HDN1F_36450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HDN1F_36460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HDN1F_36470	COG0640	Transcriptional regulator
HDN1F_36480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HDN1F_36490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HDN1F_36500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HDN1F_36560	COG4771	TonB-dependent receptor
HDN1F_36650	COG1960	acyl-CoA dehydrogenase activity
HDN1F_36740	COG3668	Plasmid stabilization system
HDN1F_36770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HDN1F_36790	COG2201	protein-glutamate methylesterase activity
HDN1F_36800	COG2198	Histidine kinase
HDN1F_36800	COG0643	Histidine kinase
HDN1F_36820	COG0840	transmembrane signaling receptor activity
HDN1F_36860	COG0189	ligase activity
HDN1F_36880	COG1678	Uncharacterized ACR, COG1678
HDN1F_36890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HDN1F_36900	COG3128	pkhd-type hydroxylase
HDN1F_36920	COG4206	TonB-dependent receptor
HDN1F_37090	COG0714	Associated with various cellular activities
HDN1F_37110	COG2010	Cytochrome c
HDN1F_37130	COG0540	Belongs to the ATCase OTCase family
HDN1F_37150	COG1309	transcriptional regulator
HDN1F_37160	COG3300	MHYT domain
HDN1F_37160	COG5001	Diguanylate cyclase
HDN1F_37180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HDN1F_37190	COG5002	protein histidine kinase activity
HDN1F_37190	COG0784	Response regulator, receiver
HDN1F_37240	COG4453	Protein conserved in bacteria
HDN1F_37320	COG0762	integral membrane protein
HDN1F_37330	COG1872	DUF167
HDN1F_37370	COG4115	mRNA cleavage
HDN1F_37400	COG3311	Transcriptional regulator
HDN1F_37520	COG1943	Transposase
HDN1F_37580	COG4263	nitrous-oxide reductase activity
HDN1F_37590	COG4221	oxidoreductase activity
HDN1F_37630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HDN1F_37640	COG1652	LysM domain
HDN1F_37650	COG0242	peptide deformylase activity
HDN1F_37660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HDN1F_37670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HDN1F_37690	COG3876	Protein conserved in bacteria
HDN1F_37770	COG1607	acyl-coa hydrolase
HDN1F_37780	COG0210	DNA helicase
HDN1F_37840	COG1388	LysM domain
HDN1F_37840	COG1376	ErfK ybiS ycfS ynhG family protein
HDN1F_37890	COG0791	NLP P60 protein
HDN1F_37910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HDN1F_37920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HDN1F_37940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HDN1F_37960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HDN1F_37980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HDN1F_38000	COG0356	it plays a direct role in the translocation of protons across the membrane
HDN1F_38020	COG1475	DNA binding
HDN1F_38030	COG1192	Involved in chromosome partitioning
HDN1F_38040	COG0357	Ribosomal RNA small subunit methyltransferase G
HDN1F_38050	COG0445	tRNA wobble uridine modification
HDN1F_38070	COG0706	membrane insertase activity
HDN1F_38080	COG0594	ribonuclease P activity