locus-tag	class	description
Halar_0049	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0061	COG1570	exodeoxyribonuclease VII activity
Halar_0106	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0127	COG1397	ADP-ribosylglycohydrolase
Halar_0130	COG0589	response to stress
Halar_0141	COG1401	restriction endodeoxyribonuclease activity
Halar_0153	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0167	COG1073	alpha beta
Halar_0172	COG1476	TRANSCRIPTIONal
Halar_0177	COG0210	DNA helicase
Halar_0184	COG1196	nuclear chromosome segregation
Halar_0234	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0252	COG1074	ATP-dependent DNA helicase activity
Halar_0263	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Halar_0299	COG2205	protein histidine kinase activity
Halar_0302	COG1028	Short-chain dehydrogenase reductase Sdr
Halar_0305	COG0318	PFAM AMP-dependent synthetase and ligase
Halar_0308	COG0179	Fumarylacetoacetate (FAA) hydrolase
Halar_0309	COG0346	lactoylglutathione lyase activity
Halar_0311	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Halar_0312	COG0601	transmembrane transport
Halar_0319	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Halar_0321	COG4608	Belongs to the ABC transporter superfamily
Halar_0322	COG0444	Belongs to the ABC transporter superfamily
Halar_0324	COG0427	acetyl-CoA hydrolase
Halar_0327	COG1414	Transcriptional regulator
Halar_0379	COG3385	transposase activity
Halar_0386	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0386	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0397	COG2135	peptidase activity
Halar_0399	COG0701	Predicted permease
Halar_0440	COG0438	transferase activity, transferring glycosyl groups
Halar_0452	COG2217	Heavy metal translocating P-type atpase
Halar_0453	COG2217	Heavy metal translocating P-type atpase
Halar_0460	COG0109	protoheme IX farnesyltransferase activity
Halar_0465	COG3385	transposase activity
Halar_0485	COG3385	transposase activity
Halar_0492	COG0864	Transcriptional regulator
Halar_0496	COG1192	Involved in chromosome partitioning
Halar_0500	COG0270	DNA (cytosine-5-)-methyltransferase activity
Halar_0512	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Halar_0530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Halar_0535	COG5002	protein histidine kinase activity
Halar_0568	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Halar_0587	COG2217	Heavy metal translocating P-type atpase
Halar_0600	COG0297	glycogen (starch) synthase activity
Halar_0606	COG1091	dTDP-4-dehydrorhamnose reductase activity
Halar_0631	COG0438	transferase activity, transferring glycosyl groups
Halar_0658	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Halar_0663	COG1192	Involved in chromosome partitioning
Halar_0673	COG3385	transposase activity
Halar_0678	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Halar_0687	COG3385	transposase activity
Halar_0701	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Halar_0722	COG0747	negative chemotaxis
Halar_0723	COG0601	transmembrane transport
Halar_0725	COG0444	Belongs to the ABC transporter superfamily
Halar_0727	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Halar_0732	COG3177	Filamentation induced by cAMP protein fic
Halar_0735	COG0006	proline dipeptidase activity
Halar_0739	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Halar_0740	COG1607	acyl-coa hydrolase
Halar_0745	COG0110	maltose O-acetyltransferase activity
Halar_0751	COG1830	Aldolase
Halar_0753	COG1250	3-hydroxyacyl-CoA dehydrogenase
Halar_0754	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Halar_0758	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Halar_0759	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Halar_0763	COG0667	Aldo Keto reductase
Halar_0769	COG0215	cysteine-tRNA ligase activity
Halar_0774	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Halar_0784	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Halar_0785	COG1058	Belongs to the CinA family
Halar_0785	COG1546	Belongs to the CinA family
Halar_0793	COG3842	ATPase activity
Halar_0794	COG1176	ABC-type spermidine putrescine transport system, permease component I
Halar_0795	COG1177	transmembrane transport
Halar_0797	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Halar_0803	COG2226	methyltransferase
Halar_0805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Halar_0806	COG0138	bifunctional purine biosynthesis protein purh
Halar_0811	COG0019	diaminopimelate decarboxylase activity
Halar_0813	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Halar_0814	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Halar_0821	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Halar_0822	COG1120	ATPase activity
Halar_0823	COG2264	protein methyltransferase activity
Halar_0826	COG2339	peptidase activity
Halar_0838	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Halar_0840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Halar_0843	COG0783	Belongs to the Dps family
Halar_0847	COG1363	Peptidase, m42
Halar_0852	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Halar_0852	COG0674	pyruvate-flavodoxin oxidoreductase activity
Halar_0853	COG1013	pyruvate-flavodoxin oxidoreductase activity
Halar_0854	COG0534	Mate efflux family protein
Halar_0856	COG0656	L-ascorbic acid biosynthetic process
Halar_0859	COG0616	signal peptide processing
Halar_0869	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Halar_0871	COG0442	prolyl-tRNA aminoacylation
Halar_0875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Halar_0876	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Halar_0878	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Halar_0886	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Halar_0886	COG1796	DNA polymerase
Halar_0888	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Halar_0891	COG2339	peptidase activity
Halar_0895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Halar_0902	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Halar_0904	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Halar_0911	COG0557	exoribonuclease II activity
Halar_0917	COG1518	maintenance of DNA repeat elements
Halar_0917	COG1468	defense response to virus
Halar_0924	COG0051	transcription antitermination factor activity, RNA binding
Halar_0925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Halar_0926	COG0460	homoserine dehydrogenase
Halar_0928	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Halar_0935	COG0049	tRNA binding
Halar_0938	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Halar_0939	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Halar_0940	COG0085	RNA polymerase activity
Halar_0941	COG0085	RNA polymerase activity
Halar_0943	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Halar_0948	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Halar_0950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Halar_0954	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Halar_0955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Halar_0956	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Halar_0958	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Halar_0960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Halar_0965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Halar_0966	COG0822	iron-sulfur transferase activity
Halar_0971	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Halar_0973	COG0384	phenazine biosynthesis protein PhzF
Halar_0977	COG1465	3-dehydroquinate synthase
Halar_0984	COG0436	Aminotransferase
Halar_0985	COG0435	Glutathione S-transferase
Halar_0987	COG0717	Belongs to the dCTP deaminase family
Halar_1001	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Halar_1001	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Halar_1003	COG0556	nucleotide-excision repair
Halar_1010	COG4948	Mandelate Racemase Muconate Lactonizing
Halar_1011	COG4948	Mandelate Racemase Muconate Lactonizing
Halar_1017	COG0179	Fumarylacetoacetate (FAA) hydrolase
Halar_1018	COG0501	Belongs to the peptidase M48B family
Halar_1028	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Halar_1030	COG1024	Enoyl-CoA hydratase
Halar_1036	COG1012	belongs to the aldehyde dehydrogenase family
Halar_1038	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Halar_1038	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Halar_1039	COG0315	cyclic pyranopterin monophosphate synthase activity
Halar_1040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Halar_1051	COG1012	belongs to the aldehyde dehydrogenase family
Halar_1062	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Halar_1066	COG0351	phosphomethylpyrimidine kinase
Halar_1067	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Halar_1069	COG1492	cobalamin metabolic process
Halar_1075	COG1028	Short-chain dehydrogenase reductase Sdr
Halar_1078	COG3842	ATPase activity
Halar_1086	COG0179	Fumarylacetoacetate (FAA) hydrolase
Halar_1103	COG1414	Transcriptional regulator
Halar_1106	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Halar_1118	COG0154	amidase activity
Halar_1120	COG1506	peptidase
Halar_1120	COG0823	Involved in the tonB-independent uptake of proteins
Halar_1120	COG4946	Tricorn protease homolog
Halar_1122	COG0601	transmembrane transport
Halar_1123	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Halar_1131	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Halar_1134	COG0598	Magnesium transport protein CorA
Halar_1137	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Halar_1142	COG4608	Belongs to the ABC transporter superfamily
Halar_1143	COG0444	Belongs to the ABC transporter superfamily
Halar_1144	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Halar_1145	COG0601	transmembrane transport
Halar_1146	COG4166	transmembrane transport
Halar_1155	COG0484	heat shock protein binding
Halar_1160	COG1902	pentaerythritol trinitrate reductase activity
Halar_1169	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Halar_1172	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Halar_1172	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Halar_1173	COG0109	protoheme IX farnesyltransferase activity
Halar_1176	COG1733	regulation of RNA biosynthetic process
Halar_1177	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Halar_1182	COG3920	Histidine kinase
Halar_1185	COG3830	Belongs to the UPF0237 family
Halar_1185	COG0560	Phosphoserine phosphatase
Halar_1186	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Halar_1197	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Halar_1199	COG0137	argininosuccinate synthase activity
Halar_1200	COG0165	Argininosuccinate lyase
Halar_1202	COG0189	ligase activity
Halar_1203	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Halar_1204	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Halar_1205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Halar_1206	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Halar_1207	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Halar_1209	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Halar_1210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Halar_1212	COG0395	ABC-type sugar transport system, permease component
Halar_1213	COG1175	transmembrane transport
Halar_1218	COG2414	aldehyde ferredoxin oxidoreductase
Halar_1220	COG1192	Involved in chromosome partitioning
Halar_1222	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Halar_1224	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Halar_1226	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Halar_1227	COG0714	Associated with various cellular activities
Halar_1241	COG0437	4 iron, 4 sulfur cluster binding
Halar_1242	COG3383	formate dehydrogenase (NAD+) activity
Halar_1250	COG2414	aldehyde ferredoxin oxidoreductase
Halar_1252	COG2205	protein histidine kinase activity
Halar_1253	COG1125	glycine betaine transport
Halar_1253	COG0517	IMP dehydrogenase activity
Halar_1258	COG1505	serine-type exopeptidase activity
Halar_1259	COG2124	cytochrome p450
Halar_1262	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Halar_1264	COG0656	L-ascorbic acid biosynthetic process
Halar_1265	COG0154	amidase activity
Halar_1268	COG1960	acyl-CoA dehydrogenase activity
Halar_1274	COG0028	Belongs to the TPP enzyme family
Halar_1275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Halar_1275	COG0425	Belongs to the sulfur carrier protein TusA family
Halar_1277	COG1404	Belongs to the peptidase S8 family
Halar_1282	COG0444	Belongs to the ABC transporter superfamily
Halar_1284	COG0601	transmembrane transport
Halar_1288	COG0569	domain protein
Halar_1289	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Halar_1294	COG0151	Belongs to the GarS family
Halar_1299	COG1098	S1 RNA binding domain
Halar_1303	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Halar_1306	COG0419	ATPase involved in DNA repair
Halar_1316	COG0512	Glutamine amidotransferase of anthranilate synthase
Halar_1316	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Halar_1317	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Halar_1319	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Halar_1322	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Halar_1326	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Halar_1329	COG2239	Acts as a magnesium transporter
Halar_1338	COG0442	prolyl-tRNA aminoacylation
Halar_1340	COG1007	ATP synthesis coupled electron transport
Halar_1348	COG0649	NAD binding
Halar_1348	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Halar_1349	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Halar_1350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Halar_1353	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Halar_1354	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Halar_1360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Halar_1361	COG0540	Belongs to the ATCase OTCase family
Halar_1362	COG1193	negative regulation of DNA recombination
Halar_1366	COG2391	methyltransferase activity
Halar_1369	COG1960	acyl-CoA dehydrogenase activity
Halar_1384	COG1024	Enoyl-CoA hydratase
Halar_1386	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Halar_1388	COG1253	flavin adenine dinucleotide binding
Halar_1392	COG1546	Belongs to the CinA family
Halar_1392	COG1058	Belongs to the CinA family
Halar_1393	COG2226	methyltransferase
Halar_1395	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Halar_1416	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Halar_1419	COG0066	3-isopropylmalate dehydratase activity
Halar_1420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Halar_1422	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Halar_1424	COG0028	Belongs to the TPP enzyme family
Halar_1426	COG0129	dihydroxy-acid dehydratase activity
Halar_1429	COG0864	Transcriptional regulator
Halar_1435	COG4608	Belongs to the ABC transporter superfamily
Halar_1436	COG0444	Belongs to the ABC transporter superfamily
Halar_1437	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Halar_1438	COG0601	transmembrane transport
Halar_1441	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Halar_1449	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Halar_1450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Halar_1452	COG0483	inositol monophosphate 1-phosphatase activity
Halar_1459	COG0561	phosphatase activity
Halar_1462	COG1960	acyl-CoA dehydrogenase activity
Halar_1464	COG0668	transmembrane transport
Halar_1467	COG0438	transferase activity, transferring glycosyl groups
Halar_1472	COG1960	acyl-CoA dehydrogenase activity
Halar_1477	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Halar_1479	COG0745	RESPONSE REGULATOR receiver
Halar_1480	COG0516	GMP reductase activity
Halar_1480	COG0517	IMP dehydrogenase activity
Halar_1483	COG2379	hydroxypyruvate reductase
Halar_1486	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Halar_1488	COG0517	IMP dehydrogenase activity
Halar_1494	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Halar_1499	COG0154	amidase activity
Halar_1502	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Halar_1505	COG1575	Belongs to the MenA family. Type 1 subfamily
Halar_1507	COG1024	Enoyl-CoA hydratase
Halar_1508	COG1757	Na H antiporter
Halar_1510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Halar_1512	COG0534	Mate efflux family protein
Halar_1529	COG4263	nitrous-oxide reductase activity
Halar_1537	COG2205	protein histidine kinase activity
Halar_1545	COG1435	thymidine kinase activity
Halar_1547	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Halar_1549	COG0148	phosphopyruvate hydratase activity
Halar_1552	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Halar_1556	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Halar_1558	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Halar_1559	COG3246	L-lysine catabolic process to acetate
Halar_1562	COG0489	protein tyrosine kinase activity
Halar_1568	COG0572	uridine kinase
Halar_1572	COG0436	Aminotransferase
Halar_1574	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Halar_1581	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Halar_1581	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Halar_1593	COG0501	Belongs to the peptidase M48B family
Halar_1594	COG1253	flavin adenine dinucleotide binding
Halar_1600	COG1216	Glycosyl transferase, family 2
Halar_1600	COG1442	glycosyl transferase family 8
Halar_1607	COG3119	arylsulfatase activity
Halar_1611	COG0297	glycogen (starch) synthase activity
Halar_1612	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Halar_1615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Halar_1616	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Halar_1624	COG0277	FAD linked oxidase domain protein
Halar_1624	COG0247	lactate metabolic process
Halar_1625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Halar_1631	COG0602	queuosine metabolic process
Halar_1632	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Halar_1634	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Halar_1636	COG0415	Belongs to the DNA photolyase family
Halar_1640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Halar_1642	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Halar_1643	COG0346	lactoylglutathione lyase activity
Halar_1646	COG3383	formate dehydrogenase (NAD+) activity
Halar_1663	COG1845	cytochrome c oxidase, subunit III
Halar_1663	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Halar_1667	COG0012	GTP binding
Halar_1673	COG0154	amidase activity
Halar_1675	COG4166	transmembrane transport
Halar_1678	COG0444	Belongs to the ABC transporter superfamily
Halar_1679	COG4608	Belongs to the ABC transporter superfamily
Halar_1691	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Halar_1693	COG1793	dna ligase
Halar_1694	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Halar_1696	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Halar_1704	COG0012	GTP binding
Halar_1707	COG0531	amino acid
Halar_1713	COG1285	pathogenesis
Halar_1720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Halar_1721	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Halar_1726	COG0402	S-adenosylhomocysteine deaminase activity
Halar_1727	COG0439	Biotin carboxylase
Halar_1733	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Halar_1735	COG0006	proline dipeptidase activity
Halar_1741	COG0010	Belongs to the arginase family
Halar_1744	COG3842	ATPase activity
Halar_1745	COG1176	ABC-type spermidine putrescine transport system, permease component I
Halar_1746	COG1177	transmembrane transport
Halar_1748	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Halar_1749	COG1402	creatininase
Halar_1750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Halar_1751	COG1250	3-hydroxyacyl-CoA dehydrogenase
Halar_1752	COG0410	ABC transporter
Halar_1755	COG0559	Belongs to the binding-protein-dependent transport system permease family
Halar_1758	COG0725	ABC transporter, periplasmic molybdate-binding protein
Halar_1759	COG4208	sulfate ABC transporter
Halar_1760	COG3842	ATPase activity
Halar_1762	COG0644	oxidoreductase
Halar_1769	COG1078	dGTPase activity
Halar_1771	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Halar_1771	COG0778	Nitroreductase
Halar_1772	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Halar_1782	COG1469	GTP cyclohydrolase I activity
Halar_1783	COG1378	Sugar-specific transcriptional regulator TrmB
Halar_1785	COG0316	Belongs to the HesB IscA family
Halar_1787	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Halar_1788	COG1278	Cold shock
Halar_1793	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Halar_1794	COG3842	ATPase activity
Halar_1795	COG0395	ABC-type sugar transport system, permease component
Halar_1796	COG1175	transmembrane transport
Halar_1798	COG1136	(ABC) transporter
Halar_1799	COG0577	efflux transmembrane transporter activity
Halar_1805	COG1073	alpha beta
Halar_1805	COG2226	methyltransferase
Halar_1808	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Halar_1810	COG0667	Aldo Keto reductase
Halar_1813	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Halar_1823	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Halar_1825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Halar_1826	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Halar_1829	COG0626	cystathionine gamma-synthase activity
Halar_1833	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Halar_1834	COG0668	transmembrane transport
Halar_1839	COG3608	succinylglutamate desuccinylase aspartoacylase
Halar_1842	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Halar_1846	COG0081	regulation of translation
Halar_1852	COG0142	geranyltranstransferase activity
Halar_1856	COG1522	sequence-specific DNA binding
Halar_1857	COG0483	inositol monophosphate 1-phosphatase activity
Halar_1860	COG4191	Histidine kinase
Halar_1864	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Halar_1865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Halar_1866	COG0667	Aldo Keto reductase
Halar_1869	COG0704	Plays a role in the regulation of phosphate uptake
Halar_1870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Halar_1871	COG0573	inorganic phosphate transmembrane transporter activity
Halar_1872	COG0573	inorganic phosphate transmembrane transporter activity
Halar_1873	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Halar_1874	COG0704	Plays a role in the regulation of phosphate uptake
Halar_1879	COG0668	transmembrane transport
Halar_1880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Halar_1882	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Halar_1883	COG0589	response to stress
Halar_1885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Halar_1893	COG1078	dGTPase activity
Halar_1898	COG0714	Associated with various cellular activities
Halar_1899	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
Halar_1900	COG1305	Transglutaminase-like
Halar_1907	COG0456	acetyltransferase
Halar_1908	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Halar_1915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Halar_1926	COG1335	isochorismatase
Halar_1930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Halar_1932	COG1053	succinate dehydrogenase
Halar_1942	COG0189	ligase activity
Halar_1942	COG0569	domain protein
Halar_1944	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Halar_1948	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Halar_1960	COG0667	Aldo Keto reductase
Halar_1961	COG1473	amidohydrolase
Halar_1965	COG0402	S-adenosylhomocysteine deaminase activity
Halar_1972	COG4948	Mandelate Racemase Muconate Lactonizing
Halar_2012	COG4608	Belongs to the ABC transporter superfamily
Halar_2013	COG0444	Belongs to the ABC transporter superfamily
Halar_2015	COG0601	transmembrane transport
Halar_2017	COG0405	Gamma-glutamyltransferase
Halar_2019	COG2267	carboxylic ester hydrolase activity
Halar_2020	COG4608	Belongs to the ABC transporter superfamily
Halar_2021	COG0444	Belongs to the ABC transporter superfamily
Halar_2023	COG0601	transmembrane transport
Halar_2024	COG0747	negative chemotaxis
Halar_2025	COG0006	proline dipeptidase activity
Halar_2028	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Halar_2040	COG1228	amidohydrolase
Halar_2043	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Halar_2045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Halar_2048	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Halar_2052	COG0579	oxidoreductase
Halar_2054	COG0306	phosphate transporter
Halar_2076	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Halar_2078	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Halar_2079	COG0010	Belongs to the arginase family
Halar_2081	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Halar_2082	COG0509	glycine decarboxylation via glycine cleavage system
Halar_2083	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Halar_2084	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Halar_2088	COG2096	Adenosyltransferase
Halar_2090	COG2205	protein histidine kinase activity
Halar_2091	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Halar_2092	COG1960	acyl-CoA dehydrogenase activity
Halar_2096	COG2267	carboxylic ester hydrolase activity
Halar_2101	COG1131	(ABC) transporter
Halar_2104	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Halar_2115	COG1233	COG1233 Phytoene dehydrogenase and related
Halar_2123	COG0402	S-adenosylhomocysteine deaminase activity
Halar_2128	COG0512	Glutamine amidotransferase of anthranilate synthase
Halar_2128	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Halar_2130	COG0135	phosphoribosylanthranilate isomerase activity
Halar_2138	COG0559	Belongs to the binding-protein-dependent transport system permease family
Halar_2139	COG0411	ABC transporter
Halar_2143	COG0277	FAD linked oxidase domain protein
Halar_2150	COG0656	L-ascorbic acid biosynthetic process
Halar_2154	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Halar_2155	COG1028	Short-chain dehydrogenase reductase Sdr
Halar_2158	COG1012	belongs to the aldehyde dehydrogenase family
Halar_2160	COG0601	transmembrane transport
Halar_2162	COG0444	Belongs to the ABC transporter superfamily
Halar_2163	COG4608	Belongs to the ABC transporter superfamily
Halar_2164	COG0473	3-isopropylmalate dehydrogenase activity
Halar_2167	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Halar_2170	COG0105	UTP biosynthetic process
Halar_2174	COG1444	tRNA N-acetyltransferase activity
Halar_2175	COG0348	domain, Protein
Halar_2178	COG0154	amidase activity
Halar_2183	COG0737	Belongs to the 5'-nucleotidase family
Halar_2189	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Halar_2190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Halar_2191	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Halar_2192	COG1363	Peptidase, m42
Halar_2195	COG0446	pyridine nucleotide-disulphide oxidoreductase
Halar_2199	COG2746	aminoglycoside 3-N-acetyltransferase activity
Halar_2204	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Halar_2213	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Halar_2221	COG0154	amidase activity
Halar_2224	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Halar_2226	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Halar_2228	COG0668	transmembrane transport
Halar_2229	COG0436	Aminotransferase
Halar_2231	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Halar_2232	COG0277	FAD linked oxidase domain protein
Halar_2233	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Halar_2235	COG0047	phosphoribosylformylglycinamidine synthase activity
Halar_2242	COG0656	L-ascorbic acid biosynthetic process
Halar_2248	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Halar_2248	COG0519	Catalyzes the synthesis of GMP from XMP
Halar_2249	COG0504	CTP synthase activity
Halar_2252	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Halar_2255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Halar_2260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Halar_2274	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Halar_2277	COG1131	(ABC) transporter
Halar_2279	COG0322	excinuclease ABC activity
Halar_2289	COG2135	peptidase activity
Halar_2290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Halar_2293	COG3852	Histidine kinase
Halar_2298	COG1525	nuclease
Halar_2303	COG0601	transmembrane transport
Halar_2308	COG1832	CoA-binding protein
Halar_2309	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Halar_2311	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Halar_2315	COG0179	Fumarylacetoacetate (FAA) hydrolase
Halar_2316	COG0006	proline dipeptidase activity
Halar_2318	COG0006	proline dipeptidase activity
Halar_2319	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Halar_2320	COG3842	ATPase activity
Halar_2322	COG1177	transmembrane transport
Halar_2324	COG0559	Belongs to the binding-protein-dependent transport system permease family
Halar_2326	COG0411	ABC transporter
Halar_2327	COG0410	ABC transporter
Halar_2331	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Halar_2337	COG1473	amidohydrolase
Halar_2339	COG0494	nUDIX hydrolase
Halar_2342	COG0492	ferredoxin-NADP+ reductase activity
Halar_2344	COG0484	heat shock protein binding
Halar_2350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Halar_2351	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Halar_2358	COG0154	amidase activity
Halar_2359	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Halar_2362	COG2133	pyrroloquinoline quinone binding
Halar_2371	COG1012	belongs to the aldehyde dehydrogenase family
Halar_2375	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Halar_2377	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Halar_2382	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Halar_2384	COG5000	phosphorelay sensor kinase activity
Halar_2385	COG1132	(ABC) transporter
Halar_2393	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Halar_2395	COG2212	antiporter activity
Halar_2400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Halar_2400	COG2111	Na H antiporter
Halar_2401	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Halar_2409	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Halar_2428	COG0531	amino acid
Halar_2433	COG1074	ATP-dependent DNA helicase activity
Halar_2449	COG2132	Multicopper oxidase
Halar_2451	COG2076	Multidrug Resistance protein
Halar_2452	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Halar_2455	COG0519	Catalyzes the synthesis of GMP from XMP
Halar_2455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Halar_2459	COG0200	Binds to the 23S rRNA
Halar_2464	COG0322	excinuclease ABC activity
Halar_2465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Halar_2466	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Halar_2468	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Halar_2471	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Halar_2474	COG0255	Belongs to the universal ribosomal protein uL29 family
Halar_2475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Halar_2477	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Halar_2478	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Halar_2481	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Halar_2488	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Halar_2492	COG0328	RNA-DNA hybrid ribonuclease activity
Halar_2492	COG0406	alpha-ribazole phosphatase activity
Halar_2495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Halar_2499	COG0559	Belongs to the binding-protein-dependent transport system permease family
Halar_2502	COG0410	ABC transporter
Halar_2504	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Halar_2506	COG0668	transmembrane transport
Halar_2508	COG1988	membrane-bound metal-dependent
Halar_2515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Halar_2526	COG0107	imidazoleglycerol-phosphate synthase activity
Halar_2542	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Halar_2545	COG2089	acid synthase
Halar_2551	COG1083	cytidylyl-transferase
Halar_2553	COG0438	transferase activity, transferring glycosyl groups
Halar_2556	COG1132	(ABC) transporter
Halar_2559	COG2267	carboxylic ester hydrolase activity
Halar_2561	COG0318	PFAM AMP-dependent synthetase and ligase
Halar_2564	COG2264	protein methyltransferase activity
Halar_2569	COG0589	response to stress
Halar_2571	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Halar_2571	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Halar_2577	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Halar_2578	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Halar_2581	COG0358	DNA primase activity
Halar_2591	COG0709	Synthesizes selenophosphate from selenide and ATP
Halar_2592	COG3844	kynureninase activity
Halar_2594	COG1252	NADH dehydrogenase
Halar_2608	COG0114	fumarate hydratase activity
Halar_2610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Halar_2612	COG1136	(ABC) transporter
Halar_2612	COG0577	efflux transmembrane transporter activity
Halar_2613	COG1136	(ABC) transporter
Halar_2613	COG0577	efflux transmembrane transporter activity
Halar_2625	COG0277	FAD linked oxidase domain protein
Halar_2625	COG0247	lactate metabolic process
Halar_2626	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Halar_2627	COG1111	helicase
Halar_2627	COG1205	dead DEAH box helicase
Halar_2628	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Halar_2629	COG0443	Heat shock 70 kDa protein
Halar_2630	COG0484	heat shock protein binding
Halar_2632	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Halar_2635	COG1372	Participates in initiation and elongation during chromosome replication
Halar_2635	COG0187	DNA topoisomerase II activity
Halar_2643	COG1473	amidohydrolase
Halar_2646	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Halar_2647	COG4608	Belongs to the ABC transporter superfamily
Halar_2650	COG0601	transmembrane transport
Halar_2651	COG4166	transmembrane transport
Halar_2656	COG0434	BtpA family
Halar_2680	COG2205	protein histidine kinase activity
Halar_2683	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Halar_2684	COG1164	Oligoendopeptidase f
Halar_2687	COG0101	tRNA pseudouridine synthase activity
Halar_2689	COG0124	histidyl-tRNA synthetase
Halar_2693	COG0392	lysyltransferase activity
Halar_2693	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Halar_2694	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Halar_2697	COG0314	molybdopterin synthase activity
Halar_2698	COG0528	UMP kinase activity
Halar_2699	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Halar_2701	COG1695	Transcriptional regulator
Halar_2714	COG0662	Cupin 2, conserved barrel domain protein
Halar_2720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Halar_2722	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Halar_2727	COG1185	polyribonucleotide nucleotidyltransferase activity
Halar_2729	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Halar_2732	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Halar_2732	COG0321	lipoyl(octanoyl) transferase activity
Halar_2734	COG0464	growth
Halar_2739	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Halar_2741	COG1022	Amp-dependent synthetase and ligase
Halar_2744	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Halar_2747	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Halar_2749	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Halar_2750	COG2968	Membrane
Halar_2752	COG0490	domain, Protein
Halar_2753	COG0475	glutathione-regulated potassium exporter activity
Halar_2758	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Halar_2763	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Halar_2766	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Halar_2771	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Halar_2775	COG0166	Belongs to the GPI family
Halar_2783	COG0431	NADPH-dependent FMN reductase
Halar_2790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Halar_2794	COG0505	Belongs to the CarA family
Halar_2796	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Halar_2797	COG2205	protein histidine kinase activity
Halar_2799	COG1063	alcohol dehydrogenase
Halar_2800	COG0521	Mo-molybdopterin cofactor biosynthetic process
Halar_2810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Halar_2811	COG1102	Psort location Cytoplasmic, score
Halar_2812	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Halar_2813	COG0303	'Molybdopterin
Halar_2814	COG0303	'Molybdopterin
Halar_2818	COG2154	pterin-4-alpha-carbinolamine dehydratase
Halar_2819	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Halar_2824	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Halar_2828	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Halar_2830	COG0083	homoserine kinase activity
Halar_2832	COG0284	orotidine-5'-phosphate decarboxylase activity
Halar_2838	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Halar_2845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Halar_2847	COG0534	Mate efflux family protein
Halar_2848	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Halar_2850	COG0022	dehydrogenase e1 component
Halar_2854	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Halar_2856	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Halar_2858	COG1012	belongs to the aldehyde dehydrogenase family
Halar_2859	COG0028	Belongs to the TPP enzyme family
Halar_2865	COG1739	Uncharacterized protein family UPF0029
Halar_2868	COG0131	Imidazoleglycerol-phosphate dehydratase
Halar_2872	COG0538	isocitrate dehydrogenase activity
Halar_2873	COG1446	asparaginase
Halar_2882	COG1185	polyribonucleotide nucleotidyltransferase activity
Halar_2886	COG0018	arginyl-trna synthetase
Halar_2888	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Halar_2888	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Halar_2891	COG0559	Belongs to the binding-protein-dependent transport system permease family
Halar_2894	COG0410	ABC transporter
Halar_2896	COG2130	NADP-dependent
Halar_2897	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Halar_2899	COG0037	tRNA processing
Halar_2899	COG0590	tRNA wobble adenosine to inosine editing
Halar_2900	COG2226	methyltransferase
Halar_2902	COG2226	methyltransferase
Halar_2904	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Halar_2916	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Halar_2918	COG0534	Mate efflux family protein
Halar_2924	COG0167	dihydroorotate dehydrogenase activity
Halar_2932	COG0556	nucleotide-excision repair
Halar_2935	COG2897	thiosulfate sulfurtransferase activity
Halar_2945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Halar_2949	COG1506	peptidase
Halar_2949	COG0823	Involved in the tonB-independent uptake of proteins
Halar_2949	COG4946	Tricorn protease homolog
Halar_2957	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Halar_2958	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Halar_2959	COG0525	valine-tRNA ligase activity
Halar_2962	COG0402	S-adenosylhomocysteine deaminase activity
Halar_2968	COG3422	double-strand break repair
Halar_2969	COG0688	phosphatidylethanolamine metabolic process
Halar_2970	COG0470	DNA polymerase III
Halar_2972	COG1234	tRNA 3'-trailer cleavage
Halar_2991	COG0024	Methionine aminopeptidase
Halar_2995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Halar_3000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Halar_3004	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Halar_3005	COG0431	NADPH-dependent FMN reductase
Halar_3006	COG2827	Endonuclease containing a URI domain
Halar_3009	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Halar_3010	COG1280	lysine exporter protein (LysE YggA)
Halar_3018	COG0142	geranyltranstransferase activity
Halar_3019	COG0596	Alpha beta hydrolase
Halar_3019	COG2226	methyltransferase
Halar_3019	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Halar_3026	COG1269	ATP hydrolysis coupled proton transport
Halar_3031	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Halar_3032	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Halar_3033	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Halar_3034	COG0459	protein refolding
Halar_3035	COG1402	creatininase
Halar_3037	COG0237	dephospho-CoA kinase activity
Halar_3047	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Halar_3056	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Halar_3058	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Halar_3059	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Halar_3065	COG3608	succinylglutamate desuccinylase aspartoacylase
Halar_3070	COG2999	glutathione oxidoreductase activity
Halar_3072	COG2252	PERMEase
Halar_3073	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Halar_3074	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Halar_3087	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Halar_3087	COG0475	glutathione-regulated potassium exporter activity
Halar_3088	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Halar_3091	COG0076	glutamate decarboxylase activity
Halar_3098	COG0024	Methionine aminopeptidase
Halar_3102	COG0531	amino acid
Halar_3110	COG0798	PFAM Bile acid sodium symporter
Halar_3112	COG0469	pyruvate kinase activity
Halar_3113	COG1940	carbohydrate kinase activity
Halar_3116	COG1012	belongs to the aldehyde dehydrogenase family
Halar_3117	COG2414	aldehyde ferredoxin oxidoreductase
Halar_3118	COG3842	ATPase activity
Halar_3119	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Halar_3120	COG1177	transmembrane transport
Halar_3121	COG1176	ABC-type spermidine putrescine transport system, permease component I
Halar_3122	COG1522	sequence-specific DNA binding
Halar_3125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Halar_3126	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Halar_3133	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Halar_3145	COG2894	cell division
Halar_3146	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Halar_3150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Halar_3159	COG1605	Chorismate mutase
Halar_3159	COG0077	Prephenate dehydratase
Halar_3160	COG2205	protein histidine kinase activity
Halar_3166	COG3273	potassium ion transport
Halar_3166	COG0471	metal ion transport
Halar_3168	COG1830	Aldolase
Halar_3169	COG0159	tryptophan synthase activity
Halar_3170	COG0133	tryptophan synthase activity
Halar_3171	COG0134	indole-3-glycerol-phosphate synthase activity
Halar_3174	COG1606	tRNA processing
Halar_3175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Halar_3190	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Halar_3192	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Halar_3193	COG0251	oxidation-reduction process
Halar_3201	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Halar_3203	COG1196	nuclear chromosome segregation
Halar_3209	COG3842	ATPase activity
Halar_3213	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Halar_3215	COG0626	cystathionine gamma-synthase activity
Halar_3227	COG0017	Asparaginyl-tRNA synthetase
Halar_3228	COG1253	flavin adenine dinucleotide binding
Halar_3230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Halar_3231	COG0009	L-threonylcarbamoyladenylate synthase
Halar_3234	COG1268	BioY protein
Halar_3235	COG1122	ATPase activity
Halar_3236	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Halar_3238	COG2181	nitrate reductase activity
Halar_3238	COG0247	lactate metabolic process
Halar_3245	COG2226	methyltransferase
Halar_3248	COG1216	Glycosyl transferase, family 2
Halar_3255	COG0519	Catalyzes the synthesis of GMP from XMP
Halar_3255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Halar_3256	COG1960	acyl-CoA dehydrogenase activity
Halar_3265	COG0459	protein refolding
Halar_3267	COG0710	3-dehydroquinate dehydratase activity
Halar_3276	COG0330	HflC and HflK could
Halar_3279	COG3842	ATPase activity
Halar_3282	COG1473	amidohydrolase
Halar_3284	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Halar_3289	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Halar_3289	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Halar_3292	COG0527	aspartate kinase activity
Halar_3295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Halar_3296	COG0372	Belongs to the citrate synthase family
Halar_3302	COG1139	Iron-sulfur cluster binding protein
Halar_3303	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Halar_3308	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Halar_3309	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Halar_3309	COG0140	phosphoribosyl-ATP diphosphatase activity
Halar_3321	COG0010	Belongs to the arginase family
Halar_3327	COG1902	pentaerythritol trinitrate reductase activity
Halar_3329	COG4948	Mandelate Racemase Muconate Lactonizing
Halar_3331	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Halar_3337	COG0601	transmembrane transport
Halar_3339	COG0444	Belongs to the ABC transporter superfamily
Halar_3340	COG4608	Belongs to the ABC transporter superfamily
Halar_3344	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Halar_3345	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Halar_3346	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Halar_3349	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Halar_3356	COG0123	including yeast histone deacetylase and acetoin utilization protein
Halar_3369	COG0113	porphobilinogen synthase activity
Halar_3370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Halar_3371	COG0181	hydroxymethylbilane synthase activity
Halar_3374	COG2860	membrane
Halar_3376	COG1067	ATP-dependent peptidase activity
Halar_3376	COG0470	DNA polymerase III
Halar_3378	COG0805	protein transport
Halar_3379	COG0805	protein transport
Halar_3382	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Halar_3386	COG0589	response to stress
Halar_3391	COG0667	Aldo Keto reductase
Halar_3393	COG4251	negative regulation of phosphorylation
Halar_3394	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Halar_3401	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Halar_3403	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Halar_3405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Halar_3407	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Halar_3409	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Halar_3413	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Halar_3414	COG1177	transmembrane transport
Halar_3415	COG1176	ABC-type spermidine putrescine transport system, permease component I
Halar_3416	COG3842	ATPase activity
Halar_3418	COG0538	isocitrate dehydrogenase activity
Halar_3424	COG0633	Ferredoxin
Halar_3424	COG0543	2 iron, 2 sulfur cluster binding
Halar_3426	COG0410	ABC transporter
Halar_3429	COG0559	Belongs to the binding-protein-dependent transport system permease family
Halar_3436	COG0747	negative chemotaxis
Halar_3437	COG0601	transmembrane transport
Halar_3438	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Halar_3440	COG2301	Belongs to the HpcH HpaI aldolase family
Halar_3447	COG0489	protein tyrosine kinase activity
Halar_3464	COG1278	Cold shock
Halar_3471	COG3273	potassium ion transport
Halar_3471	COG0471	metal ion transport
Halar_3481	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Halar_3485	COG1132	(ABC) transporter
Halar_3491	COG2210	Belongs to the sulfur carrier protein TusA family
Halar_3492	COG0425	Belongs to the sulfur carrier protein TusA family
Halar_3493	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Halar_3493	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Halar_3495	COG2391	methyltransferase activity
Halar_3506	COG0673	inositol 2-dehydrogenase activity
Halar_3513	COG0587	DNA-directed DNA polymerase activity
Halar_3514	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Halar_3516	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Halar_3517	COG1201	RNA secondary structure unwinding
Halar_3521	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Halar_3523	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Halar_3527	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Halar_3527	COG0674	pyruvate-flavodoxin oxidoreductase activity
Halar_3528	COG1013	pyruvate-flavodoxin oxidoreductase activity
Halar_3529	COG1522	sequence-specific DNA binding
Halar_3535	COG1213	nucleotidyl transferase
Halar_3535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Halar_3537	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Halar_3539	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Halar_3542	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Halar_3543	COG1253	flavin adenine dinucleotide binding
Halar_3544	COG0301	tRNA thio-modification
Halar_3546	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Halar_3548	COG1331	Highly conserved protein containing a thioredoxin domain
Halar_3550	COG0151	Belongs to the GarS family
Halar_3553	COG1024	Enoyl-CoA hydratase
Halar_3554	COG1250	3-hydroxyacyl-CoA dehydrogenase
Halar_3555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Halar_3556	COG0183	Belongs to the thiolase family
Halar_3557	COG1278	Cold shock
Halar_3573	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Halar_3573	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Halar_3581	COG3396	Phenylacetate-CoA oxygenase
Halar_3584	COG2151	metal-sulfur cluster biosynthetic enzyme
Halar_3590	COG0396	ATPase activity
Halar_3591	COG0719	Fe-S assembly protein
Halar_3592	COG0719	Fe-S assembly protein
Halar_3609	COG1278	Cold shock
Halar_3612	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Halar_3615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Halar_3616	COG0183	Belongs to the thiolase family
Halar_3618	COG0596	Alpha beta hydrolase
Halar_3624	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Halar_3629	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Halar_3630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Halar_3641	COG1233	COG1233 Phytoene dehydrogenase and related
Halar_3645	COG1506	peptidase
Halar_3651	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Halar_3651	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Halar_3652	COG1703	isobutyryl-CoA mutase activity
Halar_3654	COG1058	Belongs to the CinA family
Halar_3654	COG1546	Belongs to the CinA family
Halar_3655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Halar_3659	COG0563	adenylate kinase activity
Halar_3662	COG0252	asparaginase activity
Halar_3668	COG1231	oxidoreductase activity
Halar_3670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Halar_3673	COG0003	Pfam Anion-transporting ATPase
Halar_3675	COG0300	oxidoreductase activity
Halar_3676	COG1515	deoxyribonuclease V activity
Halar_3688	COG0210	DNA helicase
Halar_3689	COG0006	proline dipeptidase activity
Halar_3694	COG3842	ATPase activity
Halar_3695	COG0189	ligase activity
Halar_3697	COG0126	phosphoglycerate kinase activity
Halar_3704	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Halar_3720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Halar_3721	COG4608	Belongs to the ABC transporter superfamily
Halar_3722	COG0444	Belongs to the ABC transporter superfamily
Halar_3724	COG0601	transmembrane transport
Halar_3725	COG0747	negative chemotaxis
Halar_3730	COG4948	Mandelate Racemase Muconate Lactonizing
Halar_3731	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Halar_3732	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins