locus-tag	class	description
A35E_00001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
A35E_00002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
A35E_00003	ENOG41090MY	MarR family Transcriptional regulator
A35E_00004	ENOG4108JJ8	(ABC) transporter
A35E_00005	ENOG4108JJ9	ABC, transporter
A35E_00006	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A35E_00007	ENOG4105DJ0	Poly(A) Polymerase
A35E_00009	ENOG4105C9M	aspartyl-trna synthetase
A35E_00011	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
A35E_00012	ENOG4105S7Z	(LipO)protein
A35E_00013	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
A35E_00014	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A35E_00015	ENOG41063SB	peptidase
A35E_00016	ENOG4105K46	50S ribosomal protein l27
A35E_00017	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
A35E_00018	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
A35E_00019	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
A35E_00021	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A35E_00022	ENOG4105C34	Pseudouridine synthase
A35E_00023	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
A35E_00024	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
A35E_00025	ENOG4105CAT	Cytidine monophosphate kinase
A35E_00026	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
A35E_00027	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A35E_00028	ENOG4105CDY	transcriptional regulatory protein
A35E_00029	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
A35E_00030	ENOG4105W4M	Transport-associated protein
A35E_00032	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
A35E_00033	ENOG4107QUT	magnesium and cobalt transport protein CorA
A35E_00035	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A35E_00036	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
A35E_00037	ENOG4105DSJ	YicC domain protein
A35E_00038	ENOG4105CUG	Oligopeptidase b
A35E_00039	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
A35E_00040	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
A35E_00041	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A35E_00042	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A35E_00043	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
A35E_00044	ENOG41072GX	Peptidase M22 Glycoprotease
A35E_00045	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
A35E_00048	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
A35E_00049	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A35E_00050	ENOG4105DK0	Indole-3-glycerol phosphate synthase
A35E_00051	ENOG4107QYG	anthranilate phosphoribosyltransferase
A35E_00054	ENOG4105FAV	ABC, transporter
A35E_00055	ENOG4105FDK	ABC transporter
A35E_00056	ENOG4105NXV	High-affinity zinc uptake system protein
A35E_00057	ENOG4105DR5	peptidase
A35E_00058	ENOG4107QYX	exodeoxyribonuclease v alpha
A35E_00059	ENOG4107QKA	exodeoxyribonuclease V beta
A35E_00060	ENOG4106H78	methyltransferase
A35E_00061	ENOG4105CSM	endonuclease III
A35E_00062	ENOG4107104	thymidine kinase
A35E_00063	ENOG4105K63	Thioredoxin
A35E_00065	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
A35E_00066	ENOG4105CAK	Cell division ATP-binding protein ftsE
A35E_00067	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
A35E_00068	ENOG4105W0E	50S ribosomal protein L33
A35E_00070	ENOG4105EST	Metal Dependent Phosphohydrolase
A35E_00071	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
A35E_00072	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
A35E_00073	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
A35E_00074	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
A35E_00075	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
A35E_00076	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
A35E_00077	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A35E_00078	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A35E_00079	ENOG4105DUX	Transporter
A35E_00080	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
A35E_00081	ENOG4107YZP	Rhodanese domain protein
A35E_00082	ENOG4105VW4	glutaredoxin 3
A35E_00084	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
A35E_00085	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
A35E_00086	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
A35E_00087	ENOG4105C75	arginyL-tRNA synthetase
A35E_00088	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
A35E_00094	ENOG4105DQF	Hydrolase
A35E_00095	ENOG4105CJ3	phosphate transporter
A35E_00096	ENOG4105CJR	Integral membrane protein (MviN
A35E_00097	ENOG4105CP7	Triose-phosphate isomerase
A35E_00098	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
A35E_00099	ENOG4105C5S	asparaginyl-tRNA synthetase
A35E_00101	ENOG4105CFU	surface antigen
A35E_00102	ENOG4105MA0	exported protein
A35E_00103	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
A35E_00104	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
A35E_00105	ENOG4105XA0	heptosyltransferase ii
A35E_00106	ENOG4105D16	lipopolysaccharide heptosyltransferase i
A35E_00107	ENOG4105VQ7	Rod shape-determining protein MreD
A35E_00108	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
A35E_00109	ENOG4105DFF	Rod shape-determining protein mreb
A35E_00110	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
A35E_00111	ENOG4105GSS	Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity)
A35E_00112	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
A35E_00113	ENOG4105CV1	Transketolase (EC 2.2.1.1)
A35E_00114	ENOG4105C31	Tryptophanyl-tRNA synthetase
A35E_00115	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
A35E_00116	ENOG4105C3G	gtp-binding protein
A35E_00117	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
A35E_00118	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
A35E_00119	ENOG4105M2J	Glutaredoxin
A35E_00120	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
A35E_00121	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
A35E_00122	ENOG4105D4A	Cell wall formation (By similarity)
A35E_00123	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
A35E_00124	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
A35E_00125	ENOG4105CFG	Acts as a chaperone (By similarity)
A35E_00126	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
A35E_00128	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
A35E_00129	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
A35E_00132	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
A35E_00133	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
A35E_00134	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
A35E_00135	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
A35E_00136	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
A35E_00137	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
A35E_00140	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
A35E_00141	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
A35E_00142	ENOG4105EGS	Mechanosensitive ion channel
A35E_00143	ENOG4105DJ4	phosphatidylserine decarboxylase
A35E_00144	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
A35E_00145	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
A35E_00146	ENOG4105KCK	Peptidoglycan-associated lipoprotein
A35E_00147	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
A35E_00148	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
A35E_00149	ENOG4105C3F	Signal peptidase i
A35E_00150	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
A35E_00151	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
A35E_00153	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
A35E_00155	ENOG4107RAQ	aminopeptidase
A35E_00156	ENOG4105C5X	domain protein
A35E_00157	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
A35E_00158	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
A35E_00159	ENOG4105D9N	nucleoside
A35E_00160	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
A35E_00162	ENOG4105C2M	dna polymerase I
A35E_00163	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
A35E_00164	ENOG4105DFA	alanine racemase domain protein
A35E_00165	ENOG4108VIA	integral membrane protein
A35E_00166	ENOG4105CSA	Coproporphyrinogen iii oxidase
A35E_00167	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
A35E_00168	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
A35E_00169	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
A35E_00170	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
A35E_00171	ENOG4105D3R	alkyl hydroperoxide reductase
A35E_00172	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
A35E_00174	ENOG4105D1S	lipid A biosynthesis
A35E_00175	ENOG4105E96	Colicin v production protein
A35E_00176	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
A35E_00177	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
A35E_00178	ENOG4107QP8	phosphohexose isomerase
A35E_00179	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
A35E_00180	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
A35E_00181	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
A35E_00182	ENOG4105EI2	Pseudouridine synthase
A35E_00183	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
A35E_00184	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
A35E_00185	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
A35E_00186	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
A35E_00187	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
A35E_00188	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
A35E_00189	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
A35E_00190	ENOG4105F73	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
A35E_00191	ENOG4105C3I	Nad-dependent epimerase dehydratase
A35E_00192	ENOG4105CKK	Glycosyl transferase, family 2
A35E_00195	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
A35E_00196	ENOG4107RJ7	Glycosyl transferase (Group 1
A35E_00197	ENOG4108WPU	DNA polymerase III subunit psi
A35E_00198	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
A35E_00199	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
A35E_00200	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
A35E_00201	ENOG4108IUZ	ABC transporter
A35E_00202	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
A35E_00203	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
A35E_00204	ENOG4108IYU	L-aspartate oxidase
A35E_00205	ENOG4105DH7	May be involved in recombination (By similarity)
A35E_00207	ENOG41090HJ	UPF0265 protein
A35E_00208	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
A35E_00209	ENOG4105C9B	Cysteine desulfurase
A35E_00210	ENOG4105JRK	feS assembly protein SufD
A35E_00211	ENOG4105C3K	feS assembly ATPase SufC
A35E_00212	ENOG4105DIW	FeS assembly protein SUFB
A35E_00213	ENOG4108Z4V	iron-sulfur cluster assembly
A35E_00214	ENOG4108M8S	permease YjgP YjgQ family protein
A35E_00215	ENOG4108K5H	permease YjgP YjgQ family protein
A35E_00217	ENOG4105KZ7	phosphocarrier protein hpr
A35E_00219	ENOG4105DSJ	YicC domain protein
A35E_00220	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
A35E_00221	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
A35E_00222	ENOG4105C2N	RNA methyltransferase TrmH family group 3
A35E_00223	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
A35E_00224	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
A35E_00225	ENOG4105EPW	hflc protein
A35E_00226	ENOG4107QJR	hflk protein
A35E_00227	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
A35E_00228	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
A35E_00229	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
A35E_00230	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
A35E_00231	ENOG4105K8N	protein family UPF0079, ATPase
A35E_00234	ENOG4105CFV	Tetratricopeptide repeat protein
A35E_00235	ENOG4105CFV	Tetratricopeptide repeat protein
A35E_00237	ENOG4107QK7	reductase
A35E_00238	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A35E_00239	ENOG4105K5M	30s ribosomal protein S16
A35E_00240	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
A35E_00241	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
A35E_00242	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
A35E_00243	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
A35E_00244	ENOG4105CGY	Dna recombination protein
A35E_00245	ENOG4107FS9	Membrane
A35E_00246	ENOG4107QN2	dihydrolipoyl dehydrogenase
A35E_00247	ENOG4107QSN	dihydrolipoamide acetyltransferase
A35E_00248	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
A35E_00250	ENOG4105EYK	Phosphatidylglycerophosphatase B
A35E_00252	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
A35E_00253	ENOG4105DP0	ferredoxin-NADP reductase
A35E_00254	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
A35E_00255	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
A35E_00256	ENOG4105C72	UPF0176 protein
A35E_00257	ENOG4105CA9	Pyruvate kinase
A35E_00258	ENOG4105C5H	ABC transporter
A35E_00259	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
A35E_00263	ENOG4105CEP	NADH dehydrogenase
A35E_00266	ENOG4105BZA	Phosphoglycerate kinase
A35E_00267	ENOG4105D2N	Aldolase
A35E_00268	ENOG4105JIM	Phosphatidylserine synthase
A35E_00269	ENOG4105C8T	Leucyl-tRNA synthetase
A35E_00270	ENOG4108U2H	Rare lipoprotein B
A35E_00271	ENOG4105DJF	DNA polymerase III, delta' subunit
A35E_00272	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
A35E_00273	ENOG4105CJN	penicillin-binding protein
A35E_00274	ENOG4105CNI	cell division protein FtsW
A35E_00275	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A35E_00276	ENOG4108ZT0	50S ribosomal protein l17
A35E_00278	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
A35E_00279	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
A35E_00280	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A35E_00282	ENOG41067V7	50S ribosomal protein L36
A35E_00283	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
A35E_00284	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
A35E_00285	ENOG4105VPB	50S ribosomal protein L30
A35E_00286	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
A35E_00287	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
A35E_00288	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
A35E_00289	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
A35E_00290	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
A35E_00291	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A35E_00292	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
A35E_00293	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
A35E_00294	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
A35E_00295	ENOG41083MP	50s ribosomal protein l29
A35E_00296	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
A35E_00297	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
A35E_00298	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
A35E_00299	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
A35E_00300	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A35E_00301	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
A35E_00302	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
A35E_00303	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
A35E_00306	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
A35E_00307	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
A35E_00308	ENOG4105VG0	50S ribosomal protein l34
A35E_00309	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
A35E_00310	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
A35E_00311	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
A35E_00312	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
A35E_00313	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A35E_00314	ENOG4107ZVW	dihydroneopterin aldolase
A35E_00315	ENOG4105CRK	lysyL-tRNA synthetase
A35E_00316	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
A35E_00317	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
A35E_00318	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
A35E_00319	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A35E_00320	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A35E_00321	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A35E_00323	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
A35E_00324	ENOG4108VZM	50s ribosomal protein L10
A35E_00326	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
A35E_00327	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
A35E_00328	ENOG4105PM1	preprotein translocase subunit SecE
A35E_00330	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
A35E_00332	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
A35E_00334	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
A35E_00335	ENOG4105MYG	DNA polymerase iii, chi subunit
A35E_00338	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
A35E_00343	ENOG4105C8N	cysteinyl-tRNA synthetase
A35E_00344	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
A35E_00346	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
A35E_00348	ENOG4105C25	Primosomal protein n'
A35E_00349	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
A35E_00351	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
A35E_00352	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
A35E_00353	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
A35E_00354	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
A35E_00355	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
A35E_00356	ENOG4105VFK	BolA family
A35E_00357	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
A35E_00359	ENOG4105CTQ	phosphohexokinase
A35E_00360	ENOG4105N4M	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
A35E_00361	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
A35E_00363	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
A35E_00364	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
A35E_00366	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
A35E_00367	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
A35E_00369	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
A35E_00370	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
A35E_00371	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
A35E_00372	ENOG41082NX	50s ribosomal protein l35
A35E_00374	ENOG4105C22	threonyL-tRNA synthetase
A35E_00376	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A35E_00377	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
A35E_00378	ENOG4105VCC	30S ribosomal protein S21
A35E_00379	ENOG4107QNR	UPF0135 protein
A35E_00380	ENOG41090A1	ferritin
A35E_00381	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
A35E_00382	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
A35E_00383	ENOG4107YIM	Involved in the transcription termination process (By similarity)
A35E_00384	ENOG4107QQB	Ribonuclease E
A35E_00385	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
A35E_00386	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A35E_00387	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
A35E_00389	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A35E_00390	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
A35E_00391	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
A35E_00393	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
A35E_00394	ENOG4105DFU	Cell wall formation (By similarity)
A35E_00395	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
A35E_00396	ENOG4105CNI	cell division protein FtsW
A35E_00397	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
A35E_00398	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
A35E_00399	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
A35E_00400	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
A35E_00401	ENOG4105CJN	penicillin-binding protein
A35E_00402	ENOG4105CJN	penicillin-binding protein
A35E_00404	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
A35E_00405	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A35E_00406	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
A35E_00408	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A35E_00410	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A35E_00412	ENOG4105VRX	Protein slyX homolog
A35E_00414	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
A35E_00415	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
A35E_00416	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
A35E_00417	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
A35E_00418	ENOG4107RZZ	dna polymerase iii epsilon subunit
A35E_00419	ENOG4105BZ1	(ABC) transporter
A35E_00420	ENOG4105BZ1	(ABC) transporter
A35E_00421	ENOG4105E66	phosphoriboisomerase A
A35E_00422	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
A35E_00423	ENOG4108R6K	riboflavin synthase, subunit alpha
A35E_00424	ENOG4105E5M	Multidrug resistance protein D
A35E_00425	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
A35E_00427	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
A35E_00428	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
A35E_00429	ENOG4105DSY	exodeoxyribonuclease V, gamma
A35E_00430	ENOG4107QMP	dna polymerase iii subunits gamma and tau
A35E_00431	ENOG4105HYY	HAD superfamily (Subfamily IF) hydrolase, YfhB
A35E_00432	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
A35E_00434	ENOG4105CGK	Exodeoxyribonuclease III
A35E_00435	ENOG4105CX6	glutaminyL-tRNA synthetase
A35E_00436	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
A35E_00437	ENOG4105C6K	Malic enzyme
A35E_00438	ENOG4105F0N	pyrophosphate phospho-hydrolase
A35E_00439	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
A35E_00440	ENOG4107QMS	site-determining protein
A35E_00441	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
A35E_00442	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
A35E_00443	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
A35E_00444	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
A35E_00445	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
A35E_00446	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
A35E_00447	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
A35E_00448	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
A35E_00449	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
A35E_00450	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
A35E_00451	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
A35E_00452	ENOG4107QTF	adenylosuccinate lyase
A35E_00453	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A35E_00455	ENOG4108UJD	30S ribosomal protein S9
A35E_00457	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
A35E_00458	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
A35E_00460	ENOG4105C3M	thioredoxin reductase
A35E_00461	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A35E_00462	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A35E_00463	ENOG4105N21	Membrane
A35E_00464	ENOG4105CUT	histidyl-tRNA synthetase
A35E_00465	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
A35E_00467	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
A35E_00468	ENOG4108Z43	UPF0250 protein
A35E_00469	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
A35E_00470	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
A35E_00471	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
A35E_00472	ENOG4105VEQ	Cold shock protein
A35E_00473	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
A35E_00476	ENOG4105CPF	Cell wall formation (By similarity)
A35E_00477	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
A35E_00478	ENOG4105EE5	Membrane protein terC
A35E_00479	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
A35E_00480	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
A35E_00481	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
A35E_00482	ENOG4105DTN	riboflavin biosynthesis protein ribF
A35E_00483	ENOG4105CDU	Replicative dna helicase
A35E_00484	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
A35E_00485	ENOG4105EUJ	GTP cyclohydrolase i
A35E_00486	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
A35E_00487	ENOG4105K59	histidine triad (HIT) protein
A35E_00488	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
A35E_00489	ENOG4108UJU	UPF0301 protein
A35E_00490	ENOG4105D7Z	glutathione synthase
A35E_00491	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
A35E_00493	ENOG4105HFZ	Membrane
A35E_00495	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
A35E_00496	ENOG4105CE9	30S ribosomal protein S2
A35E_00497	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
A35E_00498	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
A35E_00499	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
A35E_00500	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
A35E_00501	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
A35E_00502	ENOG4105KNE	Phosphatidate cytidylyltransferase
A35E_00503	ENOG4105DZP	Membrane-associated zinc metalloprotease
A35E_00504	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A35E_00505	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
A35E_00506	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A35E_00507	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
A35E_00508	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A35E_00509	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A35E_00510	ENOG4105C0B	DNA polymerase III (alpha subunit)
A35E_00511	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
A35E_00512	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A35E_00513	ENOG4108K5P	(LipO)protein
A35E_00514	ENOG4108Z6B	deaminase
A35E_00515	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
A35E_00516	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
A35E_00517	ENOG4108EQA	pts system
A35E_00518	ENOG4105ETZ	PTS System
A35E_00519	ENOG4105F3R	pts system mannose fructose sorbose family iid
A35E_00520	ENOG4105VIE	preprotein translocase, subunit YajC
A35E_00521	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
A35E_00522	ENOG4105CS9	pantothenic acid kinase
A35E_00523	ENOG4105CD8	aminopeptidase N
A35E_00524	ENOG4105D60	lipoprotein releasing system transmembrane protein
A35E_00525	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A35E_00526	ENOG4105D60	lipoprotein releasing system transmembrane protein
A35E_00527	ENOG4108JA2	transcriptioN-repair coupling factor
A35E_00528	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
A35E_00529	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
A35E_00530	ENOG4105DGW	oligopeptidase A
A35E_00531	ENOG4105DBI	uridine monophosphokinase
A35E_00532	ENOG4105C4R	Atp-dependent dna helicase
A35E_00533	ENOG4105FE9	pseudouridine synthase
A35E_00534	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
A35E_00535	ENOG4106W5V	Membrane
A35E_00536	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
A35E_00537	ENOG4105UBK	short-chain dehydrogenase reductase
A35E_00538	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
A35E_00540	ENOG4108UUM	single-stranded DNA-binding protein
A35E_00541	ENOG4105KB2	stringent starvation protein b
A35E_00542	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
A35E_00543	ENOG4105CJB	Exodeoxyribonuclease I
A35E_00544	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A35E_00545	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A35E_00546	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
A35E_00548	ENOG4105CEN	a g-specific adenine glycosylase
A35E_00549	ENOG4105CEN	a g-specific adenine glycosylase
A35E_00550	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
A35E_00551	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
A35E_00552	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
A35E_00553	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
A35E_00554	ENOG4105BZ1	(ABC) transporter
A35E_00558	ENOG4105D9M	gamma-glutamylcysteine synthetase
A35E_00559	ENOG4105C0H	protease
A35E_00560	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
A35E_00561	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
A35E_00562	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
A35E_00563	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
A35E_00564	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
A35E_00565	ENOG4105DJV	ribulose-phosphate 3-epimerase
A35E_00566	ENOG4105EIN	peptidylprolyl cis-trans isomerase
A35E_00569	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A35E_00570	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
A35E_00571	ENOG4105VGS	50s ribosomal protein l32
A35E_00572	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
A35E_00573	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
A35E_00574	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
A35E_00575	ENOG4105CHR	reductase
A35E_00576	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
A35E_00577	ENOG4105DAN	ATP-dependent protease
A35E_00580	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
A35E_00581	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
A35E_00582	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
A35E_00583	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
A35E_00584	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
A35E_00585	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
A35E_00586	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
A35E_00587	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A35E_00588	ENOG4105EEI	dihydropteroate synthase
A35E_00589	ENOG4105EEI	dihydropteroate synthase
A35E_00590	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
A35E_00594	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
A35E_00595	ENOG4105CHV	Transcription elongation factor NusA
A35E_00596	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
A35E_00597	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
A35E_00598	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
A35E_00600	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A35E_00601	ENOG4105C1J	atp-dependent rna helicase
A35E_00602	ENOG4105F8V	Hydrolase, tatD family
A35E_00603	ENOG4107QRG	dna polymerase iii
A35E_00604	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
A35E_00605	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
A35E_00606	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
A35E_00607	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
A35E_00608	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
A35E_00609	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
A35E_00610	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
A35E_00613	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
A35E_00614	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A35E_00615	ENOG4105C3J	Cysteine desulfurase
A35E_00616	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
A35E_00622	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
A35E_00625	ENOG4105E55	glycerol-3-phosphate acyltransferase
A35E_00626	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)