locus-tag	class	description
MGATCC33530_0001	ENOG410885N	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
MGATCC33530_0004	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
MGATCC33530_0006	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
MGATCC33530_0019	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
MGATCC33530_0029	ENOG4107S0N	DJ-1 family
MGATCC33530_0030	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
MGATCC33530_0041	ENOG41082BZ	phosphocarrier protein (HPr)
MGATCC33530_0052	ENOG4107ZT6	cytidine deaminase
MGATCC33530_0060	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
MGATCC33530_0084	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
MGATCC33530_0086	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
MGATCC33530_0090	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
MGATCC33530_0091	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
MGATCC33530_0095	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
MGATCC33530_0096	ENOG41087V7	Binds to the 23S rRNA (By similarity)
MGATCC33530_0103	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
MGATCC33530_0105	ENOG4105C3M	thioredoxin reductase
MGATCC33530_0107	ENOG41074W1	Preprotein translocase subunit SecG
MGATCC33530_0111	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
MGATCC33530_0116	ENOG4105DJV	ribulose-phosphate 3-epimerase
MGATCC33530_0119	ENOG4107VSQ	competence damage-inducible protein cinA
MGATCC33530_0130	ENOG4105C31	Tryptophanyl-tRNA synthetase
MGATCC33530_0132	ENOG4107W91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
MGATCC33530_0136	ENOG4107Z60	histidine triad (HIT) protein
MGATCC33530_0153	ENOG4107WHP	riboflavin
MGATCC33530_0159	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
MGATCC33530_0161	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
MGATCC33530_0162	ENOG4108B8U	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
MGATCC33530_0163	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MGATCC33530_0164	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
MGATCC33530_0165	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
MGATCC33530_0170	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
MGATCC33530_0171	ENOG41080DU	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
MGATCC33530_0174	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
MGATCC33530_0176	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
MGATCC33530_0177	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
MGATCC33530_0179	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
MGATCC33530_0180	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
MGATCC33530_0181	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
MGATCC33530_0182	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
MGATCC33530_0183	ENOG41067V7	50S ribosomal protein L36
MGATCC33530_0189	ENOG4108JJB	ABC transporter
MGATCC33530_0204	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
MGATCC33530_0205	ENOG41086CC	50s ribosomal protein L35
MGATCC33530_0206	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
MGATCC33530_0207	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
MGATCC33530_0217	ENOG4107HHA	Glycoprotease family
MGATCC33530_0218	ENOG4105C34	Pseudouridine synthase
MGATCC33530_0226	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
MGATCC33530_0244	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
MGATCC33530_0252	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
MGATCC33530_0254	ENOG4107Y7S	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
MGATCC33530_0255	ENOG41087JC	Protein of unknown function (DUF464)
MGATCC33530_0256	ENOG4105K46	50S ribosomal protein l27
MGATCC33530_0267	ENOG4107XQK	5-formyltetrahydrofolate cyclo-ligase
MGATCC33530_0270	ENOG4108V39	SAM-dependent methyltransferase
MGATCC33530_0283	ENOG41082EV	50s ribosomal protein l31
MGATCC33530_0293	ENOG4108K4B	hydrolase
MGATCC33530_0301	ENOG4105C7S	Dehydrogenase
MGATCC33530_0306	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
MGATCC33530_0317	ENOG4107YHV	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
MGATCC33530_0338	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
MGATCC33530_0340	ENOG4105C1C	ABC transporter
MGATCC33530_0341	ENOG4108IJ3	abc transporter atp-binding protein
MGATCC33530_0370	ENOG410865Q	Potassium uptake protein
MGATCC33530_0375	ENOG4108C4V	50S ribosomal protein L33
MGATCC33530_0379	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
MGATCC33530_0382	ENOG4105CDY	transcriptional regulatory protein
MGATCC33530_0385	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
MGATCC33530_0386	ENOG410853A	UPF0154 protein
MGATCC33530_0391	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
MGATCC33530_0394	ENOG4105Q8W	reductase
MGATCC33530_0415	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
MGATCC33530_0417	ENOG4107URM	50S ribosomal protein l10
MGATCC33530_0418	ENOG41082SK	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
MGATCC33530_0425	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
MGATCC33530_0429	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
MGATCC33530_0451	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
MGATCC33530_0455	ENOG4108YZG	isomerase
MGATCC33530_0461	ENOG4106F7A	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
MGATCC33530_0463	ENOG41082I9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
MGATCC33530_0474	ENOG4108UJD	30S ribosomal protein S9
MGATCC33530_0480	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
MGATCC33530_0482	ENOG41084QT	50S ribosomal protein L28
MGATCC33530_0486	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
MGATCC33530_0490	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
MGATCC33530_0497	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
MGATCC33530_0506	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
MGATCC33530_0508	ENOG4107XYG	UTP-glucose-1-phosphate uridylyltransferase
MGATCC33530_0513	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
MGATCC33530_0515	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
MGATCC33530_0521	ENOG4105VG0	50S ribosomal protein l34
MGATCC33530_0526	ENOG4105EZN	Cobyrinic acid ac-diamide synthase