locus-tag	class	description
MGATCC33530_0001	COG0592	DNA-directed DNA polymerase activity
MGATCC33530_0004	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MGATCC33530_0006	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MGATCC33530_0019	COG0484	heat shock protein binding
MGATCC33530_0026	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MGATCC33530_0029	COG0693	protein deglycase activity
MGATCC33530_0030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MGATCC33530_0041	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MGATCC33530_0050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MGATCC33530_0052	COG0295	cytidine deaminase activity
MGATCC33530_0060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MGATCC33530_0076	COG0556	nucleotide-excision repair
MGATCC33530_0084	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MGATCC33530_0086	COG0193	aminoacyl-tRNA hydrolase activity
MGATCC33530_0088	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MGATCC33530_0090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MGATCC33530_0091	COG0049	tRNA binding
MGATCC33530_0095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MGATCC33530_0096	COG0359	binds to the 23S rRNA
MGATCC33530_0103	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MGATCC33530_0105	COG0492	ferredoxin-NADP+ reductase activity
MGATCC33530_0111	COG0194	GDP metabolic process
MGATCC33530_0116	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MGATCC33530_0119	COG1546	Belongs to the CinA family
MGATCC33530_0130	COG0180	Tryptophanyl-tRNA synthetase
MGATCC33530_0131	COG1393	Belongs to the ArsC family
MGATCC33530_0132	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MGATCC33530_0136	COG0537	adenosine 5'-monophosphoramidase activity
MGATCC33530_0138	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MGATCC33530_0142	COG0481	GTPase activity
MGATCC33530_0149	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MGATCC33530_0150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MGATCC33530_0151	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MGATCC33530_0153	COG0196	riboflavin kinase activity
MGATCC33530_0159	COG0051	transcription antitermination factor activity, RNA binding
MGATCC33530_0161	COG0088	Forms part of the polypeptide exit tunnel
MGATCC33530_0162	COG0089	rRNA binding
MGATCC33530_0163	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MGATCC33530_0164	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MGATCC33530_0165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MGATCC33530_0170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MGATCC33530_0171	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MGATCC33530_0174	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MGATCC33530_0176	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MGATCC33530_0177	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MGATCC33530_0178	COG0200	Binds to the 23S rRNA
MGATCC33530_0179	COG0201	protein transport
MGATCC33530_0180	COG0563	adenylate kinase activity
MGATCC33530_0181	COG0024	Methionine aminopeptidase
MGATCC33530_0182	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MGATCC33530_0183	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MGATCC33530_0189	COG1122	ATPase activity
MGATCC33530_0204	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MGATCC33530_0205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MGATCC33530_0206	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MGATCC33530_0217	COG1214	PFAM Peptidase M22, glycoprotease
MGATCC33530_0218	COG0564	pseudouridine synthase activity
MGATCC33530_0226	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MGATCC33530_0237	COG3266	domain, Protein
MGATCC33530_0243	COG2001	Belongs to the MraZ family
MGATCC33530_0244	COG0275	rRNA processing
MGATCC33530_0252	COG1780	Probably involved in ribonucleotide reductase function
MGATCC33530_0254	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MGATCC33530_0255	COG2868	ribosomal protein
MGATCC33530_0256	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MGATCC33530_0258	COG0735	belongs to the Fur family
MGATCC33530_0267	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MGATCC33530_0270	COG2384	SAM-dependent methyltransferase
MGATCC33530_0283	COG0254	rRNA binding
MGATCC33530_0290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MGATCC33530_0293	COG0561	phosphatase activity
MGATCC33530_0298	COG1196	nuclear chromosome segregation
MGATCC33530_0301	COG0508	dehydrogenase complex catalyzes the overall conversion of
MGATCC33530_0306	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MGATCC33530_0317	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MGATCC33530_0322	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MGATCC33530_0328	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MGATCC33530_0338	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MGATCC33530_0340	COG1122	ATPase activity
MGATCC33530_0341	COG1122	ATPase activity
MGATCC33530_0370	COG0569	domain protein
MGATCC33530_0375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MGATCC33530_0377	COG2267	carboxylic ester hydrolase activity
MGATCC33530_0379	COG1160	GTP binding
MGATCC33530_0382	COG0217	transcriptional regulatory protein
MGATCC33530_0385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MGATCC33530_0386	COG3763	UPF0154 protein
MGATCC33530_0389	COG0822	iron-sulfur transferase activity
MGATCC33530_0391	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MGATCC33530_0394	COG0431	NADPH-dependent FMN reductase
MGATCC33530_0415	COG2255	four-way junction helicase activity
MGATCC33530_0417	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MGATCC33530_0418	COG0222	ribosome binding
MGATCC33530_0419	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MGATCC33530_0420	COG0268	Binds directly to 16S ribosomal RNA
MGATCC33530_0425	COG0416	fatty acid biosynthetic process
MGATCC33530_0429	COG0301	tRNA thio-modification
MGATCC33530_0437	COG0357	Ribosomal RNA small subunit methyltransferase G
MGATCC33530_0451	COG0459	protein refolding
MGATCC33530_0452	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MGATCC33530_0455	COG0698	ribose 5-phosphate isomerase
MGATCC33530_0457	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MGATCC33530_0458	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MGATCC33530_0461	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGATCC33530_0463	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MGATCC33530_0468	COG0704	Plays a role in the regulation of phosphate uptake
MGATCC33530_0474	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MGATCC33530_0480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MGATCC33530_0482	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MGATCC33530_0486	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MGATCC33530_0490	COG0528	UMP kinase activity
MGATCC33530_0497	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MGATCC33530_0499	COG0335	large ribosomal subunit rRNA binding
MGATCC33530_0506	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MGATCC33530_0508	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MGATCC33530_0509	COG1764	response to oxidative stress
MGATCC33530_0515	COG0039	L-malate dehydrogenase activity
MGATCC33530_0518	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MGATCC33530_0521	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MGATCC33530_0525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MGATCC33530_0526	COG1192	Involved in chromosome partitioning