LOCUS GU943072 18941 bp DNA linear ENV 25-JUL-2016 DEFINITION Uncultured phage MedDCM-OCT-S08-C304 genomic sequence. ACCESSION GU943072 VERSION GU943072.1 KEYWORDS ENV. SOURCE uncultured phage MedDCM-OCT-S08-C304 ORGANISM uncultured phage MedDCM-OCT-S08-C304 Viruses; environmental samples; uncultured environmental isolates. REFERENCE 1 (bases 1 to 18941) AUTHORS Ghai,R., Martin-Cuadrado,A.B., Molto,A.G., Heredia,I.G., Cabrera,R., Martin,J., Verdu,M., Deschamps,P., Moreira,D., Lopez-Garcia,P., Mira,A. and Rodriguez-Valera,F. TITLE Metagenome of the Mediterranean deep chlorophyll maximum studied by direct and fosmid library 454 pyrosequencing JOURNAL ISME J 4 (9), 1154-1166 (2010) PUBMED 20393571 REFERENCE 2 (bases 1 to 18941) AUTHORS Ghai,R., Martin-Cuadrado,A.-B., Molto,A.G., Heredia,I.G., Cabrera,R., Martin,J., Verdu,M., Deschamps,P., Moreira,D., Lopez-Garcia,P., Mira,A. and Rodriguez-Valera,F. TITLE Direct Submission JOURNAL Submitted (26-FEB-2010) Departmento de Produccion Vegetal y Microbiologia, Evolutionary Genomics Group, Universidad Miguel Hernandez, Apartado 18, San Juan de Alicante, Alicante 03550, Spain FEATURES Location/Qualifiers source 1..18941 /organism="uncultured phage MedDCM-OCT-S08-C304" /mol_type="genomic DNA" /isolation_source="deep chlorophyll maximum in the Mediterranean off the coast of Alicante, Spain, 50m below sea surface" /db_xref="taxon:743577" /clone="MedDCM-OCT-S08-C304" /environmental_sample /country="Spain" /lat_lon="38.068511 N 0.231994 W" /collection_date="15-Oct-2007" /note="genome fragment from metagenomic fosmid library MedDCM-OCT constructed from 0.2-5 um-sized plankton" CDS 73..342 /note="MedDCM-OCT-S08-C304-cds1" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95457.1" /translation="MNHAAKKAFGKGHPTKVIAQNKPPEGTPCPICKSSMLHGQKNKS MCFDHDHKTHTFRGWICRECNMAIGHLGDTVEGLQAALDYLKIQN" CDS 343..630 /note="MedDCM-OCT-S08-C304-cds2" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95458.1" /translation="MKLLIDCDYIVYKCCASTETEIDFGDDVILVTSLFSEAYKCVER ELDKVKREFPFYDEIILFFTSPNNFRKKSYRVTKVIEIEKSPVDSKESYRN" CDS 1516..2805 /note="MedDCM-OCT-S08-C304-cds4" /codon_start=1 /product="ribonucleotide reductase domain protein" /protein_id="ADD95459.1" /translation="MEGPNGIEASWRFVSHALRYGAGVSVHLSKLRPAGTTTNKGPDS LVASGPVSFAKFYSTLNEILRRGGTYRNGAVVLALDITHTDILEFVLAKREELPWVKR CINLTPDQWRNSKATTKEAIIRGIARGDIWLNKIKYDNEGNRIYSNVCLEVYLPSRGT CLLQHLNLAACRIGDLQEGFSAGMSSLCELHGRTGIGESGEYLTPDIDRQVGFGLLGL SNFLANNNITYAEFGKALTATNNAEPYEGYAGLAARELFLGIQKAANIARQNNMKRAF AIAPTASCSYRSRDLNGYTATPEIAPPIARTVDRDSGEFGVEQVQYGNVEIASEVGWE NYKRVADQIMIMLDRTGLLHGYSFNSWSDMVTYDEAFIEEWLKSPQTSLYYSLQVMGD TQDKSDAYAALDQSEVDDYLADLMSNKPEEINCDCQQ" CDS 2802..3515 /note="MedDCM-OCT-S08-C304-cds5" /codon_start=1 /product="hypothetical protein PSSP7_021" /protein_id="ADD95460.1" /translation="MNPYEKLLNRKRKWTPVQTTKGRVKYGAEETIFRALAVRNMECP VGSFISDSLSEIPEKSRKLLESNVKDEDNHDLALGYIANALGVDDKAEAEAIRLKDAW IAHPDHTILKALVIERAIFFVILPFFRFNGDAGLRTVSADISRDEQIHVATNSLVCAE LGLKPSPSLDKLRKATINWIMQPLNAIHDDQYLSRKFWLDASDRLMYEGKAPEFNATK AARMPAFFEHANTNLPQYS" CDS 3484..3675 /note="MedDCM-OCT-S08-C304-cds6" /codon_start=1 /product="hypothetical protein PSSP7_022" /protein_id="ADD95461.1" /translation="MQTQISLNTLKLHNERLDKLLVRLEENFGWKPIHPKEDVQTIMY RAGQASVIEYIKSIMEDEI" CDS 3675..3950 /note="MedDCM-OCT-S08-C304-cds7" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95462.1" /translation="MCFFRSPKPPAAPPPLPPAPVPPSPPPVPEPLPEEEVRPVNPAV REAQSKLGTKKGQKGSTADLRIKKATASSGATASLNPGNTNTTGGIQ" CDS 5518..6015 /note="MedDCM-OCT-S08-C304-cds9" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95463.1" /translation="MADTLTIKQDDQSTDVENLTTEEQDSLQVGEEMAKEQGELLAGK YKNAEDLEKAYVELQKKLGDKEEPEATKDEEEVTDEKDEPKEKSEAYSLIESASDEYF KNGESLSPETLEKFKGMSSQDLVNGYMQMVKDNPQTNNTEVDVNTAEINKIQNSVGGE AQYNN" CDS 6367..6573 /note="MedDCM-OCT-S08-C304-cds10" /codon_start=1 /product="hgh light inducible protein" /protein_id="ADD95464.1" /translation="MKTKDLDTLLENEYPYEPPVRIIPMSHHNTNPLMTHEAERFNGW AAMLGFVAAVGAYVTTGQIIPGIF" CDS 6732..7811 /note="MedDCM-OCT-S08-C304-cds11" /codon_start=1 /product="core photosystem II reaction center protein" /protein_id="ADD95465.1" /translation="MAAISLQRDTTTNWEKFCNWVTSTDNRIYVGWFGVLMIPCLLAA TTCFILAFIAAPPVDIDGIREPVSGSLLYGNNIISGAVVPSSNAIGLHFYPIWEAATL DEWLYNGGPYQLVIFHFLIGVAAYAGRQWELSYRLGMRPWIFVAYTAPLSAALAVFLV YPFGQGSFSDGMPLGISGTFNFMFVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSL VTSSIIKETTEDMSQNYGYKFGQDEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLA TWPVVGIWLTSMGVCTMAFNLNGFNFNQSIVDTNGKVIPTWADVVNRQNLGMEVMHER NAHNFPLDLASTESTEVALTAPQIG" CDS 8288..9601 /note="MedDCM-OCT-S08-C304-cds12" /codon_start=1 /product="minor capsid protein 10" /protein_id="ADD95466.1" /translation="MADANQVGVGRINLSSGVGYDGAGDKYATYLKLFSGEMFKGFQH NTIARDLVTKRTLKNGKSLQFIYTGRMTSDYHTPGTPILGNADKAPPVAEKTIVMDDL LVSSAFVYDLDETLSHYDLRGEISRKIGYALAENYDRKIFRAIAKGARQASPISATGF VEPGGTQIQLNGTQNNTQATTASNLVTGFYDAASVLDEKGVSSDGRVAVLNPRQYYAL IQQTGDNGLINRDVQGTGLQSGEGVVSIAGIKIYKSMNLPFLGKFGTANTISNAGSFI GQSMDSGSGRQTATYARSGTTITVTLNAHGLSVGDKVVFDATAGGGTSGTYTVATVAT NTFTITDTVSGTVSGGTACAFNIAGVNNGYGEAGDFAGSCGLIFQKEAAGVVEAIGPQ VQVTNGDISVIYQGDVILGRMAMGADYLNPAACVELHVGTADAAF" CDS 9643..10056 /note="MedDCM-OCT-S08-C304-cds13" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95467.1" /translation="MCAPTQTSSNYGPIGSVRNYSPAKQERFEAEVAKTQQKLQDAGY TPSGHAFDPFGGGPMSAMGEMIWAMKDAEKYPEISERDPAYALNQNEEQNQGTNKRLL KIKNQSSIKIGNRKSKLNKSGGSGSLRKPMKTLNT" CDS 10061..10678 /note="MedDCM-OCT-S08-C304-cds14" /codon_start=1 /product="T7-like tail tubular protein A" /protein_id="ADD95468.1" /translation="MATTTIDPDTELSAVNSILGSIGQSPLTTLNFNNPETAFVYNLL VEANKDIQNEGWHFNTEENVKVTPDTTTKYIVIPSNYLRYDLHDKRIDKTKDLVRRNG RLYDLVEHTDQFTEDQYLDIVTLYPFSDVPPVFQRYIISRASVRAAVQQVANKELAAL LQIQEQTARANVMDYECSQGDHNYMGWPEKTAYAPFQPFQILNRR" CDS 12133..12576 /note="MedDCM-OCT-S08-C304-cds16" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95469.1" /translation="MPIQLVRQANGTFTVSQATWENADVGDTLTNPNPSFVGKTVNQL VFFRNRLVFLSDENVIMSRPGEFFNFWSKTATTFTPQDVIDLSCSSEYPAIVYDGIQV NAGLLLFTKNQQFMLTTDSDILSPETAKLNAVASYNFNEKPTLFL" CDS 12630..13610 /note="MedDCM-OCT-S08-C304-cds17" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95470.1" /translation="MSNVLRQGEPDVVDQSKVISRLLDKDISLVSESRENSAVFFSKK GTDEIYCFRYFNSGDKRLLQAWCTWTLAGNIQYHCMLDDALFVITRNNNKDQMVKYSL KLDDNGHSVTDTRDTADTSDDYIYRVHLDHSSSVTAASGTYNSATLKTTIPKPNGYEN TKQLVAYETDSGNDLGRYSMVTVNGSNLEIVGDWSNNTFVIGYLYEMDVQIPTIYVTR AEGDKYRADAKSSLIVHRIKFSFGPLGVYSTTLQRVGKPDYTETKELALAGVVSASRL PIVNEVIETVPCYERNTNLTVNVKSEHPAPATLYSLAWEGDFTNRFYRRV" CDS 13630..14049 /note="MedDCM-OCT-S08-C304-cds18" /codon_start=1 /product="hypothetical protein PSSP7_032" /protein_id="ADD95471.1" /translation="MEAALDVASNLLPDDRREVEEGHGHDPVVAIPACSVIGDTVYFT VPNGELAGVAGVQEDGRIWMLCTPAIHKYPLTFAREAKRYVESRQEKLLWNIVDKRNR VHIKLLRFLGFKFLRELKHGPNNLSFMEFCRVFRSTS" CDS 14633..15313 /note="MedDCM-OCT-S08-C304-cds20" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95472.1" /translation="MRLDFNEVPDYASILEKSYQSVNRSYNEREEAERRNDERRIKNA GMPLKMIEAIAQFAPKAKELADGLKLQQQKRQQKEFNQSKFANYTIDQLKAVEEREKL GNKFVRDQYFAKLKVAKKINEEGKIIEALDTIDSSTYKKIKYGLRNALIKNHKAGSLE RFNKVAGDISGLSLEDKQDAYRRFKQADTDDFDDYGDAFQKDLEEHYASEEKLFMAEN KKYIKNNG" CDS 15406..16392 /note="MedDCM-OCT-S08-C304-cds21" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95473.1" /translation="MEHIETVKNEKGYETFGEAYQFVMRDALEMVKSGDIKPEIARKL EALYVLHRGKKGAPKELILDSHSKMLAQINWDKELHDAETEYYELEEEEAENYENSKI ADMKQQRKDNGSFTEKDLADFLRTNWDYDTYGTPSSSVTGFATDEDKNDADLKPYLQI QWDQGRLTEDMVYKLKSAEDRETWMSRVGTTSPNGVSKDDLKDAITASKDIRNDLAST KGFKLTNNKQVLGNVQKNAEWYFPGLYADAMKDANSPADAYIKAKNEMKAIIATGKWD TLQSASTDVNDRKRNLSLAQGQLKNDMTVVNTSIIAGTEDILEEAAELHNKI" CDS 16401..17048 /note="MedDCM-OCT-S08-C304-cds22" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95474.1" /translation="MYVQLANGLRIDGKRPHPLALQEMQLEVRSKLMDAGKPVKSVVL QAWEAMPETSQELLSAHASPARLTRAKIEAFFGEGDNVAGTIDYNDPAISSMVNEILS NKDGLYTEFLNDREVDPRYLFGRSEVDKDEKYRTQFKKLSNRVSYSKWRSERSDGVAA EKLKEFIQSGLRLPGMLLEDVFATESAAFGFIGEGLEQRREEVKKQKIEENAINY" CDS 17057..18415 /note="MedDCM-OCT-S08-C304-cds23" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95475.1" /translation="MNPDDFQLDVDAMEFAKDGIDFQERYEEAEKQQAYQQQQELQLE NEATQAKAELDDPREREGGGGLRGVVKEVQSAIGGGLQDTASSVVTLPERAIDMFSGE MQEEQATDEGYGAEWDDWFVDDANPIETKTWWGGALRSLVHFGSMAAAIIPAAKVAGV TAATTVVGSLARGAAVGAASDVVSKYSQEDNGLAILRDRFNFIDTPLATKDTDHPAMK TLKNVVEGMGIGVIFDSASMLIGKGVKKVKGSGQPIKRTVSGKLELPDTRGKGKFYHG TSEEIPDGRVTSVESGENLTDTNLYGNGFYTTEDLTTASKYKKKNKNVGKPKRGDYTW KDNPEEAYQKDLEAFNKRKEDPITYEITEKSPVQFIDADQKINWTADTPEAKTIKEFL AQTDEGNEVLAAWEKSQSFSYGDITNDLKDIFQRAELSRGEVTDFIDELNLKLKALVM ED" CDS 18759..>18941 /note="MedDCM-OCT-S08-C304-cds24" /codon_start=1 /product="hypothetical protein" /protein_id="ADD95476.1" /translation="MGSSDSVTTPKRLASYTTPVETELMVRSSQMAEDHVVEILGEFM TDARLQTEIQAARKQGK" ORIGIN 1 aaaactaatt cttacggtaa acattacacc cgtgcaatat gtaactcctg ttacaaccaa 61 ggcaaactaa gcatgaatca tgctgccaaa aaagcttttg gtaaaggaca cccaactaaa 121 gtcattgctc aaaataaacc accagaaggt actccatgtc ccatatgcaa atcatcaatg 181 cttcatggtc agaaaaacaa atctatgtgt tttgaccacg accataaaac ccatactttt 241 agaggatgga tttgtagaga atgcaatatg gctataggac atttaggaga cactgtggaa 301 gggttacaag cagcacttga ctacttaaaa attcaaaact gaatgaaact attaattgat 361 tgcgactata tcgtatataa atgctgtgca tcgacagaaa cagaaatcga ctttggtgac 421 gatgtaatac tcgtaacttc actgtttagt gaagcttata aatgtgtaga aagagaatta 481 gacaaagtaa aacgtgaatt tccgttttat gacgaaatta tcctcttttt tacaagtcct 541 aataatttta ggaaaaaatc ttaccgagtt acaaaggtca tcgaaataga aaaaagccct 601 gtggattcaa aagagtcata cagaaactaa aagaaaatta caaggtgata atcaaggata 661 ctcttgaagc agatgatgct atgggaatct acgcaactaa atatacaggc aacataattg 721 ttagtcctga taaagatatg cgtcagattg ctggtaaatt atatgatttc aatgagacag 781 ttgagattac cccagaagag ggtgctagat ggcatctaat tcaagctatg gctggcgata 841 acactgacgg ttactcagga gttccaggaa ttggtataaa acgtgctgaa caaatcttta 901 aattgaaagg ctacacatgg aaagcggtag tagaaacatt tgaagagaaa ggcatgactg 961 aacagacgca ttagttaatg cacaactagc aagaatactt actgttgacg actatgactc 1021 aaagaaaaag aacccatcct ctggaccgcc gaagccaatt acaaaattga cgatggagca 1081 agacttgaag ctgcgacagc ttgagatctt actagctaaa ccagagacaa gaaaggaaga 1141 cattatcaca gtgatgattg ctcttcaaga acaagcattt gttctatcaa attgtattaa 1201 aaaccttata gataaatggc cgaaaccacc aacgaccacg gacctcgtac tacagacgag 1261 gttccattga tgtttgggat tttattagag accaaggact cggatttcac ttaggaaacg 1321 tcatcaaata tacatgcaga gccggacata aagacaacga catagaagat ttaaaaaaag 1381 ctatccacta tttatcaaat gaaatcgaat accgaaccaa acatcatagc taggactgga 1441 agagtccaag catggattga caatccaaca tcccgtctgc ccgtgtcatg cacaatcttc 1501 aacgttgaag actcaatgga aggaccaaat ggaatcgaag caagctggag atttgtatca 1561 cacgctctta gatatggagc gggtgtctca gtccacctgt cgaaacttag accagcggga 1621 acaactacta ataaaggacc tgattcactt gttgcatcag gaccagtctc attcgcaaaa 1681 ttctactcaa cattaaatga aatacttagg agaggtggaa cctatcgtaa cggtgcggtg 1741 gttcttgccc ttgatattac tcacaccgat attcttgagt tcgtgctcgc aaaaagagaa 1801 gaactcccct gggttaagcg atgtattaac ctcaccccag accagtggcg taattcaaaa 1861 gctacaacaa aggaagcaat tattagagga attgcaaggg gagacatttg gctcaacaaa 1921 ataaaatatg acaatgaagg aaacagaatc tactccaacg tctgtcttga ggtttacttg 1981 ccctcacgcg gaacgtgctt gttacaacac ctcaatctcg ctgcctgtcg catcggcgac 2041 ttacaagagg gtttcagtgc tggtatgtcc agcctgtgtg aactccacgg taggacaggg 2101 attggagaat ctggagagta tcttacgcca gatatcgata ggcaagtcgg attcggattg 2161 ctcggtctat ccaacttcct cgccaacaac aacataactt atgccgagtt tggtaaggct 2221 cttacagcaa ctaataatgc tgaaccttac gaaggctacg cgggattagc tgcccgtgag 2281 ctctttctcg gcatacaaaa agcagctaac attgcaagac agaacaacat gaagagagca 2341 tttgccatag ctccaacagc aagttgttca tatagaagta gagatctcaa tggctacaca 2401 gcaactcctg agatcgcacc acctatagca agaactgttg acagggattc aggtgaattt 2461 ggggtagaac aagtacaata tggcaacgtt gaaatcgcat ccgaagttgg atgggagaat 2521 tataaaagag tagctgatca aataatgatc atgctagata gaactggttt gcttcatggc 2581 tatagcttca attcttggag cgatatggtg acttacgatg aagcatttat cgaagagtgg 2641 ctgaaaagtc cacagacttc gctctattat tccttacaag taatgggcga cactcaagat 2701 aaatctgatg catacgctgc attggatcag tcagaagttg acgattactt ggcagactta 2761 atgagcaaca aacctgaaga gattaattgc gactgtcaac aatgaacccc tacgaaaaat 2821 tattaaatag aaaaaggaaa tggacacctg tccaaactac taaaggaaga gtaaaatatg 2881 gcgcagaaga aaccattttc cgtgctctcg ctgtacgcaa tatggaatgt ccagttggct 2941 cgtttatatc tgattcactc tctgagattc cagagaaaag tagaaaactt ttggaatcaa 3001 atgtaaaaga tgaagacaac cacgacttag cccttggata tatcgctaac gctctaggcg 3061 tagatgataa agccgaagcc gaagcaatac gcctaaaaga tgcatggata gctcatccag 3121 atcacacaat attgaaagca ttagttatag aaagagcaat cttttttgta attcttcctt 3181 tctttagatt taatggtgat gctggattaa gaactgtcag tgcagatata tctagagacg 3241 agcaaataca tgtagcaact aatagtttgg tatgtgcaga gcttggtctt aaaccaagtc 3301 cttctttaga caagctaagg aaggcaacaa ttaattggat catgcaaccg ttaaatgcga 3361 tacatgacga tcaatatttg agcagaaaat tttggcttga tgctagtgat cgtttgatgt 3421 acgaaggtaa agcaccagaa tttaatgcca ccaaagctgc acgtatgcca gctttctttg 3481 aacatgcaaa cacaaatctc cctcaatact cttaagcttc acaacgaaag gttagacaag 3541 ctgttagtaa gacttgagga aaactttgga tggaaaccta tccatcctaa agaagatgta 3601 cagacaataa tgtaccgagc tggacaagcc agcgttatcg aatatataaa atccatcatg 3661 gaggatgaaa tctaatgtgt ttttttagat caccaaaacc accagcagca ccgccaccat 3721 taccaccagc accagtacct ccttcacctc ctccagttcc agaaccactt cccgaagaag 3781 aagtaagacc agttaaccct gcggttcgtg aagctcaatc aaagcttgga actaagaaag 3841 gtcagaaagg tagtacagca gatttaagaa ttaaaaaagc aactgcttca tcaggagcaa 3901 ctgcttcatt aaatcctgga aatactaata ctactggagg tattcagtag tgaacgcacg 3961 tgaaaaatat aatcagctta gttctgctag acgacagttc ctcgacaaag cagttcaatg 4021 ctctgaactc acgttgccat atttaattga tgacgatata tcatcaagac caaaccacaa 4081 atcattatca gtaccttggc aatcagtcgg agccaagtgt gtggtgactt tagctgcaaa 4141 gcttatgctt gcagttctac ctccacagac aagtttcttc aagctacagg tacgggatga 4201 caagttagga caagaactag acccacaaat aagaagtgaa ttagatcttt catttgcaaa 4261 aatggaaagg atgatcatgg aatatatagc tgctagtaat gatcgagttg caatacacca 4321 agcacttaaa catttaattg ttggtggtaa tgcattgatc ttcatgcaca aagatgggtt 4381 aaagactttt cctttaacta gatatgttgt cgaaagagat ggtgatggta acgttttatg 4441 catagtcact aaggaactta taagtagaaa agtattagat attgatttac cagaacctga 4501 accaaattca gtggtagatg aatctaattc agttgcagat gatgtaacta tatacactat 4561 ggttcgacta gataaagcta gtggcagatg gatatggcat caagaagcat ttgataaaat 4621 cattcctgat acaagaagta ctgcacctaa gaaagccagt ccctggttgc ctttacggtt 4681 caatacagtt gatggagaag actatggtcg tggaagagta gaagaatttt taggagattt 4741 aaaatcactt gatggtttaa gtcaagctct gattgaagga gctgctgctg ccagtaaagt 4801 tatttttctt gtctctccaa gttcaactac taaaccagcc accattgcaa aggctggtaa 4861 cggagcaatt gttcagggta gaccagaaga cgttgcagtt atccaagtag gaaaaactgc 4921 tgacttcgct acagctgcac agatggctca aaatatagag agaagaatgt tagaagcttt 4981 ccttgttatg aacgtaaggc aagcagaaag agttacagct gaagaggtac gcctcacaca 5041 gttggaacta gaacaacaac tcggcggtat attttcgtta cttacagttg agttcctaat 5101 accttatctc agtagaacct tattagtttt acaaagatct aatgagatac caaagttacc 5161 taaagatata gtacgtccaa caatagttgc tggcgttaat gctttaggta gaggacaaga 5221 tagagaatca ttaactcagt tcattgggac tattgctcag actttaggac cagaagcttt 5281 aatgcaatac attaatccag cagaagctat caaacgattg gcagctgctc agggtattga 5341 tgtacttaat cttgttaaga ctgaacagca gatggcagaa gaaatgcaag ctgcacaaca 5401 agcacaaaca caacaatctc tggttgatca agctggacaa ttagctggta ctccattaat 5461 ggacccacaa aaaaatccac agatgatgcc agaagaagaa ccacccgctg aataaatatg 5521 gctgatacat taactatcaa acaagatgac cagtctacag atgtagaaaa tctgacgact 5581 gaagagcaag actccctgca agtcggggag gaaatggcta aagagcaagg tgaattactt 5641 gctggtaaat ataaaaatgc tgaagattta gaaaaggctt acgttgaact tcaaaagaaa 5701 ttaggagaca aggaagaacc tgaagctact aaggatgaag aagaagttac tgatgagaaa 5761 gatgaaccaa aggaaaagag tgaagcttat tcattaattg aatcagctag tgatgagtac 5821 tttaaaaatg gtgaatcttt atctccagaa actcttgaga aatttaaagg tatgagtagt 5881 caggatttag ttaatggcta tatgcaaatg gtcaaagata atcctcaaac taataatact 5941 gaagttgatg taaacacagc agagattaat aaaatacaaa actctgttgg tggtgaagct 6001 caatacaata attagttaca tgggctggaa acaatcttcc agaaaatgaa attaaagctt 6061 tcgatgattt agttggcact ggtaatgcag ctgctattca gttaggagtt gatgctatca 6121 aatctagata cgaagcagtt aatggctacg aaggacggag actgacaggc aaagctgctg 6181 ataacagcgg tgatgtattt aaaagtcaag cccaattagt agaagctatg agcgaccctc 6241 gctatgacag agaccctgct tatagacagg atgttgtagc aaaacttgaa cgatcagata 6301 tcgattttta attatgccta aaggaaaagg aacctacgga accaaaaaag gtagaccacc 6361 taaaaaatga aaactaaaga tttagacaca ctactcgaaa acgaataccc ttacgaacca 6421 ccagtacgaa ttattcctat gtcacaccac aatacaaatc ctcttatgac acatgaagcg 6481 gaacgcttta acggctgggc tgcaatgctt ggctttgttg ctgctgtcgg tgcttatgtc 6541 accacaggtc agatcatacc cggcatcttc tgatccatac aaatggaaga tgagttgctt 6601 cgattttctt gaagcaagat acaaagtgat actcgatgag gatctacctc ttaagaataa 6661 gatggacctc atcaattttt tcctctccaa agtggacgag gaatgcgaca acattcattt 6721 acattaatca catggctgca atctcattac aaagagacac tacaaccaat tgggaaaagt 6781 tttgtaactg ggtaactagc acagacaacc gcatatatgt tggttggttt ggagtgctaa 6841 tgataccttg cttactagct gcaaccacct gttttattct cgcctttatc gctgctcctc 6901 cagtggacat cgatggcata cgtgaaccag tatcaggttc tttgttgtac ggaaacaaca 6961 taatatcagg agctgtcgtc ccctcctcta atgcaatcgg actacatttc tatcctattt 7021 gggaagctgc cacgctagac gagtggttat acaacggcgg accatatcag ttagttatat 7081 tccactttct cattggagtg gctgcgtatg cagggagaca atgggaacta tcttaccgcc 7141 tcggcatgcg accttggatc tttgtagctt atacagctcc attgtcagca gctctagcgg 7201 tttttctcgt ataccctttc ggacaaggga gttttagtga tggtatgcct cttggtattt 7261 ctggtacttt taacttcatg ttcgtattcc aagcagaaca caatatcctt atgcatccgt 7321 tccacatgct cggtgttgct ggggtattcg gtggatctct tttctctgct atgcacggaa 7381 gtcttgttac ttcctcaatc attaaagaga caacagaaga tatgtcacag aactatggtt 7441 ataaatttgg tcaagacgag gagacttaca acatcgttgc agctcatggc tacttcggta 7501 gattaatttt ccagtatgcg tctttcaata actctcgttc tcttcatttc tttcttgcta 7561 cttggccggt tgttggcata tggctgacat ctatgggcgt atgcactatg gcgtttaacc 7621 ttaatggttt taactttaac caatcaatag ttgatactaa tggcaaagtt attcctactt 7681 gggctgacgt tgtaaacaga cagaacttag gtatggaagt aatgcacgag cgtaacgctc 7741 acaacttccc acttgatttg gcttcaactg aatcaacaga agttgcatta acagctccac 7801 aaattggcta aaaattttgt ttatacctaa ccttaatcac taacttattt atatgctctg 7861 gcgttatccg ccattggaat agtatgcaaa caaagacaca gaaattctag aactacagaa 7921 acaggtagat aaattactag aggaatatag acaagaagaa tataaaagga aagatgagcc 7981 aataggcgat tcttcatact aaccacgact tccgttcatc ctgttttagg acgcatgaaa 8041 accaaagcat ggaacggggc tttggtatat gggagaaacc aatggttact tacgtatatc 8101 gtggcgttgt ttacactaag taaatgacaa cagaaaggga gcacctcaga gtcggactcc 8161 ctttcacttt ggctttttgc cctccaagga ggataccaat cagccgtcta gacggtggga 8221 tagaccacaa aaatgatcaa aaaaattctg tacggaagaa agtaaacaat aaaatttttt 8281 aaataaaatg gctgatgcta atcaggtcgg tgtaggtaga attaatctat cttccggcgt 8341 aggttatgac ggagctggtg acaagtacgc cacctatctt aaactcttta gtggagagat 8401 gtttaaggga ttccaacata atacaattgc tcgtgactta gttacgaagc gtacattgaa 8461 gaacggaaag agtcttcaat tcatctacac aggtcgcatg acaagtgact atcacacacc 8521 tggaactcct atattaggaa acgctgacaa agcacctcca gttgctgaga aaacaattgt 8581 tatggatgac cttctagtca gttctgcatt cgtgtatgac cttgacgaga cactctctca 8641 ctatgatttg agaggagaaa tttctcgtaa gattggttat gctcttgctg aaaactatga 8701 cagaaaaata ttcagagcta ttgctaaagg tgcacgtcaa gcatctccta tatctgctac 8761 tggtttcgtt gaacccggtg gtacacagat tcagttaaat ggtactcaga acaatacaca 8821 agcaactact gcttctaacc ttgttactgg tttttatgac gctgcgagtg tattagatga 8881 gaaaggagta agttctgacg gacgtgtagc tgtacttaac ccaagacagt actacgcact 8941 tatccaacaa acaggtgaca atggactaat caacagagac gttcagggta caggtttaca 9001 gtctggagaa ggcgttgtat ctatcgctgg tattaagatc tacaagtcaa tgaacctacc 9061 attcttaggt aagttcggta ctgctaatac tatctccaat gctggttcat tcataggtca 9121 atctatggat tctggttctg gtagacagac agcaacttat gcaagatctg gaacaactat 9181 cacagtaact cttaacgctc acggtctatc cgttggtgat aaagttgtct ttgatgctac 9241 agctggtgga ggtacttcag gtacatacac agttgctact gttgctacaa atacattcac 9301 aattactgat actgtaagtg gaaccgtttc aggcggaaca gcttgtgctt tcaatattgc 9361 tggtgttaac aatggctatg gtgaggctgg agactttgct ggatcatgtg gtttaatctt 9421 ccaaaaagaa gctgctggtg tagtagaggc aattggtcct caagttcaag taactaatgg 9481 agacatatcc gttatttacc aaggcgatgt gatcctcgga cgcatggcta tgggagcaga 9541 ttacttaaac cctgctgctt gcgtggaact acacgtaggt acagcagacg ctgctttcta 9601 aatttatata ctttatacgg gagcttaggc tccctttttt ttatgtgtgc acctactcaa 9661 accagtagta actatggacc tattggaagt gttagaaatt attctccagc aaaacaagaa 9721 agatttgaag ctgaagttgc aaaaactcaa caaaaactac aagatgctgg ttacactcca 9781 tccggtcatg catttgaccc ctttggtggt ggaccaatgt ctgctatggg agaaatgata 9841 tgggcgatga aagatgctga aaaatatcca gagatatcag agcgtgatcc agcttatgct 9901 ttaaaccaaa acgaagaaca aaaccaaggg acaaataaac gtttactgaa aatcaaaaat 9961 caaagcagta ttaaaattgg aaaccgaaaa agcaaattaa ataaatctgg tggcagtgga 10021 tcattacgaa aaccaatgaa aactttaaac acttaaaact atggctacta caactattga 10081 ccccgatacc gaactatccg cagtgaactc aattttgggt agcataggtc aatcaccttt 10141 aactactcta aattttaata atccagaaac tgcatttgtt tataacctat tagttgaagc 10201 taataaggat atacaaaacg aaggatggca ttttaatact gaagagaatg taaaagttac 10261 tcctgataca actacaaaat acatagttat ccctagtaac tatttaagat atgatttaca 10321 tgataaacgt attgataaaa caaaggattt agttagaaga aacggaagac tatatgactt 10381 agttgaacac actgatcaat ttactgagga tcaatattta gatattgtca ctctctatcc 10441 attttcagat gttcctccag tttttcaaag atatattatt tccagagctt ccgtccgtgc 10501 agctgtacag caagttgcaa ataaagaatt agcagcatta ctacagatac aagagcaaac 10561 tgctagagca aacgtaatgg attatgaatg cagtcaaggc gaccataact atatgggctg 10621 gccggagaaa actgcgtatg caccattcca accgttccaa atattaaata gaagataatg 10681 gcaagtgtta ctcaaacata ccaacgctga ctggaggttt atctcaacag ccagatgaac 10741 ttaagattcc tggacaggtt agtgtcgcta ataatgtaat acctgatgta acacacggct 10801 tattaaagcg tccaggagga cagttggtgg catcaattag cgataatgga accgcagctt 10861 taaactcaca aacaaacggt aaatggttct cctactaccg tgacgagaca gaaagttata 10921 taggacaaat cagtagaaca ggtgatgtaa atatgtggag atgtagtgac ggagcagcaa 10981 tgaccgttaa ctatgatggt gcaacatcga gtgcattagc tacatattta tctcatagtg 11041 atgaccaaga tattcagacc ttaactctta acgattacac gtttataact aatagaacta 11101 agacggtagc gatgtcatct actgttgaga ctgttagacc tcctgaagtc tttattgatt 11161 tgagagctac agcttacgct agacaatatg cacttaattt atatgacaac acaaacacca 11221 caactgaaac cacagctaca agaattagtg ttgatctagt taagtcaagt aataactatt 11281 gtcaaaatga tactaataat agtttaggaa ctagagcaca acgtattact gctacaaata 11341 gatgtggtac tgctgctgga gatggtaggg atgcatatgc accaaacgta ggaactagaa 11401 tatttgatat tgatgatgga gctagtctta cagatgaagc taactcagga aatcatacat 11461 acacaattga tgtaaaagct tctaatggta gttcagttaa tagaggaact aatctatatt 11521 tcagaattag aactactgga cagtcagttc catttacaag tggttcaggt gaaagccaaa 11581 caactacata tcaagctaga tatacaacta ctttcgatct tttatatggt ggatctggtt 11641 ggcagcaagg tgattatttt tatgtatgga tggatgatgg ttactacaag ataactgtag 11701 aagctattag tactacacag atacaagcaa acttaggact aattagacct aaccctacac 11761 cttttgatac tgaaactaca gtcactgctt caggaatact tggagatata aggcaagcaa 11821 taatagatac tggtaacttt acttcttcta atgtaaagca gattggtaat gggatatatg 11881 taactagagc atcaggtacg ttaacgttac ctcacctaca agtgacttac ttaaagtaat 11941 gtctagtgaa gttaaaacgt agatgattta cctgatcaat gtaagcatgg gtatgtagtt 12001 aaagtagcta acagtgaagc tgacgaagat gattactatg taaaattctt tggaaataat 12061 gatagagatg gagatggagt ttgggaggaa tgtgcaaaac ccggcagaaa tatagagttt 12121 gataaaggca ctatgcctat tcaattagtc agacaagcca acggtacatt cactgtttca 12181 caagcaactt gggaaaacgc tgatgtagga gatactttaa ctaaccctaa tccctctttt 12241 gttggtaaaa cagttaatca attagttttc tttagaaaca gattagtctt cttaagtgat 12301 gaaaacgtaa tcatgtcaag acctggagag ttttttaact tctggtctaa gacagctacc 12361 accttcacac cacaagatgt tatcgatctt tcttgcagtt ctgaataccc agctattgtt 12421 tatgacggta tccaagttaa tgccggatta ttattattta ctaagaatca gcaatttatg 12481 ctgactaccg atagtgatat tttaagtcca gaaactgcaa aacttaacgc agtagcatct 12541 tataacttta acgaaaaacc aaccctgttt ctttaggaac tactgttgcc tttatagata 12601 atgcaaataa atacacacgt ttcttcgaga tgtctaatgt acttaggcag ggagaaccag 12661 atgtagttga tcagagtaaa gttatctcaa gattattaga taaggatata agtctagtat 12721 ctgaatcacg agagaactca gctgtattct ttagtaaaaa aggaacagat gaaatctatt 12781 gttttagata ttttaatagt ggagacaagc gattactaca agcgtggtgt acgtggactc 12841 ttgcagggaa tattcaatat cactgcatgt tagatgatgc tttatttgtt attactcgaa 12901 ataataataa agatcaaatg gttaaatatt ctttaaagct agatgataat ggtcactctg 12961 taactgatac cagagacact gctgacacat cagatgacta tatatatcgt gttcacttag 13021 atcactcttc atcagtaacc gcagcttcag gtacatataa tagtgcaact cttaaaacta 13081 ctattcctaa accaaatggt tacgaaaata ctaaacagtt agttgcttat gaaactgatt 13141 caggaaatga tcttggaaga tattcaatgg tcactgtcaa tggttctaat ttagaaatag 13201 ttggagattg gtctaacaat acttttgtta ttggttatct ctatgagatg gatgtacaga 13261 ttccaactat ctatgtaact agagctgaag gagataagta cagagctgat gctaaatcat 13321 cattaattgt acatagaatt aaatttagct ttggaccatt aggagtttat tcaacaacct 13381 tacaaagagt aggtaaacca gactacacag aaactaaaga actagcttta gctggtgtgg 13441 tttctgcaag tagattaccg atagtaaatg aagttataga aacagtacct tgttacgaga 13501 gaaatacaaa cttaacagta aacgttaaat cagaacatcc agcaccagcc accctgtatt 13561 cattggcatg ggaaggagac tttacaaaca gattttatag acgtgtctaa atttattcac 13621 ccaataacga tggaagctgc acttgatgta gcttctaatc ttttaccaga tgaccgtaga 13681 gaagtagaag agggtcatgg acatgatcct gttgtggcta taccagcgtg ttccgtaata 13741 ggagacactg tatatttcac agttccaaac ggtgaacttg ccggagtagc cggcgtacaa 13801 gaagatggca gaatctggat gctatgtaca ccagctattc ataaataccc actaactttt 13861 gctagagaag caaaaagata tgtggaaagt agacaagaga agttgctctg gaacatcgtt 13921 gataaacgaa acagagttca tataaaacta ctcagattcc tagggttcaa atttttaagg 13981 gaattaaaac acggacccaa taatttatcc tttatggagt tttgccgtgt gtttaggagc 14041 acaagctaga gcacagaatg aagctgctcg cagacaatat aaatatcaga atgaaaagcg 14101 tgaacgtcaa tggatgcaaa ctcttagtat ctatgattca aaaataattc aatctgaaat 14161 taattcacaa aatgctttga tggctatgca aggtgcagct actgacgctc aactgcaacg 14221 tcaacaagca agagatgatg cacaagttaa gtatcaagaa atgtatgtag aacttttaaa 14281 taaaagtgat acagcaaaat taattgcaag tggtcagaca ggacaatcta ttagaaaaat 14341 gcgaacaaat gaaattgcta aatatggtag aaatgtatct gagattggaa ggcaattagt 14401 taataacgat tatgcaatta acaaagaatt agctaaagct aaaggacaag ctaaaggata 14461 tgtagatgca caatatgcag aagtagcatt ccagccaata ccagatgttg caccaccaca 14521 acctgttatg cagagtgttg gagccgctgc atttatggat gcattatcta ttggttcatc 14581 tatagcaact atgggtggtg ctaatggttt cggaatttgg ggaccttaaa ttatgagatt 14641 agattttaat gaagtacccg attatgcctc gatacttgaa aaaagttatc aaagtgttaa 14701 tcgaagttat aacgagagag aggaagctga aaggcgtaat gatgaaaggc gtataaaaaa 14761 cgctggcatg cctctcaaaa tgatagaagc tattgctcaa tttgcaccta aagccaaaga 14821 attagcagat ggtttaaaac tacagcaaca gaaaagacag caaaaagaat ttaaccaaag 14881 taagtttgca aactatacta ttgaccaact taaagctgtt gaagaaagag aaaaactagg 14941 taataaattt gttagagacc agtactttgc aaagttaaaa gtagctaaaa agataaatga 15001 agaaggaaag ataattgaag ctttagatac tattgatagt agtacttata aaaaaattaa 15061 atatggttta agaaatgctt taattaaaaa tcataaagct ggaagtcttg aacgttttaa 15121 taaagtagct ggtgatattt ctggattatc tttagaagat aaacaggatg catataggag 15181 attcaaacaa gctgatactg atgacttcga tgattatggt gatgcttttc aaaaagattt 15241 agaggagcat tatgcttctg aagaaaagct cttcatggct gaaaataaga aatatatcaa 15301 gaacaatggt tagtaaaaca ggatggagaa aggcgtgaaa tattaaaagg gattttaaaa 15361 tttgataatg atcaagaagg tcgtaataat ttccaaacca atgtgatgga acacattgag 15421 actgttaaaa atgaaaaggg atatgagact tttggtgaag catatcaatt tgttatgcgt 15481 gatgctttag aaatggttaa gtcaggagat attaaacctg aaatagctcg taaattagaa 15541 gcactatacg tattacatcg aggaaaaaaa ggtgcaccta aagaactaat actagattct 15601 cattctaaaa tgttggctca aattaattgg gataaagagt tgcatgatgc tgaaaccgaa 15661 tattatgagc ttgaagaaga agaggctgaa aactatgaga acagtaaaat agctgatatg 15721 aaacagcaga ggaaagataa tggatctttc acagaaaaag acttagctga ctttttaaga 15781 actaattggg attatgatac atatggaaca ccttcatctt cagtaacagg ttttgctact 15841 gatgaagata agaacgatgc agacctaaaa ccatacttac agattcaatg ggatcaaggt 15901 aggttaactg aagatatggt ttataagtta aagagtgcag aagatagaga aacatggatg 15961 tcaagagtcg gcacaaccag tcctaatggt gtaagtaaag atgatttaaa ggatgccata 16021 acagcttcta aagatatacg aaatgattta gcaagtacta aaggatttaa attaacgaat 16081 aataaacaag ttttaggtaa tgtccagaaa aatgctgaat ggtattttcc aggtttgtat 16141 gccgatgcaa tgaaagatgc taatagtcca gctgatgcat atataaaagc taaaaatgaa 16201 atgaaagcaa ttatagctac tggtaaatgg gacactcttc aatcagcttc tacggatgtt 16261 aatgacagaa aacgtaattt atcacttgca caaggtcagc taaaaaatga tatgaccgtt 16321 gttaacacat caataattgc tggtactgaa gatattcttg aagaagcagc tgaattacat 16381 aataaaatat agcccatcct atgtatgttc aattagcaaa tggattaaga atagatggta 16441 aacgacctca tcctctagca cttcaagaaa tgcaattaga agttagaagt aaattaatgg 16501 atgctggtaa gccagttaag tctgtggttc tacaagcttg ggaagctatg cctgaaactt 16561 ctcaggaact attaagtgca catgcatctc cagctagatt aactagagca aagattgaag 16621 ctttctttgg agaaggtgat aatgtagctg gaactattga ttacaatgac cctgctataa 16681 gttctatggt aaatgaaata ttatctaaca aagatggatt atacactgaa tttttaaatg 16741 atagagaggt agaccctaga tatttatttg gaagatctga agtagataaa gatgaaaaat 16801 acagaactca atttaaaaaa ctatctaata gagtttcata ctctaaatgg agaagtgaac 16861 gaagtgatgg tgtggctgcc gaaaaactta aagagtttat acagtctgga ttgagacttc 16921 ctggaatgct tctagaagat gtatttgcaa cagaatcagc tgcctttggt ttcataggag 16981 aaggtttaga acaaagaaga gaagaagtta aaaaacaaaa aatagaagaa aacgcaatta 17041 attactaagg taaaaaatga atcctgatga ttttcaactg gatgttgatg caatggagtt 17101 cgctaaggac ggcattgatt tccaagaaag atatgaggag gctgaaaaac aacaagcgta 17161 tcaacaacaa caagaacttc aacttgaaaa tgaagcaact caagctaagg ctgagttgga 17221 tgaccctcgt gaacgtgaag gcggtggagg attaagagga gttgttaaag aagtccaatc 17281 tgccataggt ggtggacttc aagataccgc ttcgtctgtt gtcactctcc cagaaagagc 17341 cattgatatg ttcagtggtg agatgcaaga agaacaagca accgatgaag gctacggagc 17401 tgaatgggat gactggtttg tagatgacgc taaccctata gaaaccaaaa cttggtgggg 17461 tggtgcatta agaagccttg tccactttgg ttcaatggct gctgctatta tccctgctgc 17521 taaggtggct ggcgtaaccg ctgcaactac agtagttgga agtcttgcaa gaggtgctgc 17581 tgtcggtgca gcgtctgatg ttgtctctaa atattcccaa gaagataatg gtctagctat 17641 tttgagagat cgttttaatt ttattgatac accattagct actaaagata ctgatcaccc 17701 tgcaatgaag acattgaaga atgttgttga aggtatgggt attggtgtta tttttgactc 17761 cgcaagtatg ctcattggta agggtgtaaa aaaagttaag ggtagtggac agcctattaa 17821 aagaacagta tctggcaaac ttgaattacc agatactaga ggtaaaggta aattttatca 17881 tggtacatcg gaagaaatac ctgacggtag agtcacaagt gtagaatctg gtgaaaattt 17941 aaccgacact aatttatatg gtaatgggtt ttatacaaca gaagacctaa ctacagctag 18001 taaatataag aagaaaaata aaaacgttgg aaagcctaaa cgtggtgatt acacatggaa 18061 agataatcct gaagaagctt atcaaaaaga tttagaggct tttaataaaa gaaaagaaga 18121 tccaattact tatgaaataa cagaaaaaag tccagtacaa tttattgatg ctgatcaaaa 18181 gattaattgg acagctgata cacctgaagc taaaactatt aaggaatttc ttgcacaaac 18241 agatgaagga aacgaagtct tagctgcgtg ggaaaaatct caatcattta gctatggaga 18301 tataactaat gatttaaaag atatttttca aagagccgaa ctttcaagag gtgaggttac 18361 tgactttata gatgaactta atttaaaatt aaaagccttg gttatggagg attaacacat 18421 aaaggtggta acttagccgg taaaggtaac agattacatc aagttaaaat atattgggat 18481 gcagaaaacc aaattgatat aaacaaagtt gattttgatt catttggtga aactgaaata 18541 gatgggtcag ttgaacaagt acaaaaagct gtaactagag aagcagatgt tgaagcacaa 18601 attagagaaa aagctgtaga tgatttacaa acaccaaact acacagcata taaaacaaag 18661 atatatcaga cccttggcaa ggtgctccaa cctccaatgg taaagctggt gaagttagag 18721 accaattaaa tcggattgaa aaagaagctg gtgcagaaat gggttctagt gactcagtta 18781 ctactccaaa aagattagct agttatacaa ctcctgtaga aactgaacta atggttagaa 18841 gctcacaaat ggctgaagat catgttgtag aaatccttgg tgagtttatg acagatgctc 18901 gtctacaaac tgaaatacaa gctgctagaa aacaaggtaa a //